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Aliases for UXT Gene

Aliases for UXT Gene

  • Ubiquitously Expressed Prefoldin Like Chaperone 2 3 5
  • Androgen Receptor Trapped Clone 27 Protein 3 4
  • Ubiquitously Expressed Transcript Protein 3 4
  • SKP2-Associated Alpha PFD 1 2 3
  • ART-27 3 4
  • Ubiquitously-Expressed, Prefoldin-Like Chaperone 2
  • Androgen Receptor Trapped Clone 27 2
  • Ubiquitously-Expressed Transcript 2
  • Protein UXT 3
  • STAP1 3

External Ids for UXT Gene

Previous GeneCards Identifiers for UXT Gene

  • GC0XM046313
  • GC0XM045771
  • GC0XM046557
  • GC0XM047267
  • GC0XM047396
  • GC0XM047511
  • GC0XM045223

Summaries for UXT Gene

Entrez Gene Summary for UXT Gene

  • The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for UXT Gene

UXT (Ubiquitously Expressed Prefoldin Like Chaperone) is a Protein Coding gene. Among its related pathways are E2F transcription factor network. GO annotations related to this gene include chromatin binding and actin filament binding.

UniProtKB/Swiss-Prot for UXT Gene

  • Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region.

Gene Wiki entry for UXT Gene

Additional gene information for UXT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UXT Gene

Genomics for UXT Gene

Regulatory Elements for UXT Gene

Enhancers for UXT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH047231 1.6 Ensembl ENCODE dbSUPER 11.7 +425.2 425163 4 SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF143 SP3 ZHX2 REST INE1 ZNF81 SNORA11C LOC100419232 UXT WASF4P UBA1 USP11 GC0XP047244 PIR42211
GH0XH048020 1.5 FANTOM5 Ensembl ENCODE 10.7 -362.2 -362246 2 TBP PKNOX1 FOXA2 ZNF76 KLF17 SIN3A RAD21 BRCA1 ZNF2 YY1 ENSG00000204620 INE1 FTSJ1 ZNF81 RBM3 ZNF630 ZNF182 NUS1P1 UBA1 PQBP1
GH0XH047559 1.4 FANTOM5 ENCODE 10.8 +96.8 96751 5 HDGF PKNOX1 ARNT SIN3A DMAP1 ZNF2 YY1 ZNF766 FOS SP3 INE1 FTSJ1 ZNF81 NUS1P1 UBA1 UXT CFP ARAF CDK16 GC0XP047571
GH0XH047216 1.4 ENCODE dbSUPER 10.6 +440.7 440662 5 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF207 ZNF143 ZNF548 LOC100113397 ZNF81 INE1 LINC01560 ZNF182 ZNF674-AS1 UBA1 RBM10 USP11 ZNF674
GH0XH047660 1.2 Ensembl ENCODE 0.7 -3.0 -3024 2 HDAC1 TBP PKNOX1 ATF1 ARNT NFRKB TCF12 FOS ATF7 CREM UXT CXXC1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UXT on UCSC Golden Path with GeneCards custom track

Promoters for UXT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246440 280 1801 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SP3

Genomic Location for UXT Gene

Chromosome:
X
Start:
47,651,792 bp from pter
End:
47,659,180 bp from pter
Size:
7,389 bases
Orientation:
Minus strand

Genomic View for UXT Gene

Genes around UXT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UXT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UXT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UXT Gene

Proteins for UXT Gene

  • Protein details for UXT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBK9-UXT_HUMAN
    Recommended name:
    Protein UXT
    Protein Accession:
    Q9UBK9
    Secondary Accessions:
    • B2R561
    • Q5JZG3
    • Q9Y6E5

    Protein attributes for UXT Gene

    Size:
    157 amino acids
    Molecular mass:
    18246 Da
    Quaternary structure:
    • Homohexamer. Interacts with LRPPRC. Interacts with AR N-terminus. In the nucleus interacts specifically with RELA and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation. Interacts with MECOM and URI1.
    SequenceCaution:
    • Sequence=AAD39840.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI42447.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for UXT Gene

Post-translational modifications for UXT Gene

  • Ubiquitination at posLast=1616, posLast=4141, Lys48, posLast=113113, posLast=126126, and Lys154
  • Modification sites at PhosphoSitePlus

Other Protein References for UXT Gene

No data available for DME Specific Peptides for UXT Gene

Domains & Families for UXT Gene

Gene Families for UXT Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for UXT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBK9

UniProtKB/Swiss-Prot:

UXT_HUMAN :
  • Belongs to the UXT family.
Family:
  • Belongs to the UXT family.
genes like me logo Genes that share domains with UXT: view

Function for UXT Gene

Molecular function for UXT Gene

GENATLAS Biochemistry:
transcript with no homology to any known gene,ubiquitously expressed,abundantly expressed in tumor tissue
UniProtKB/Swiss-Prot Function:
Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region.

Gene Ontology (GO) - Molecular Function for UXT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity IEA,IDA 21730289
GO:0003682 chromatin binding IDA 21730289
GO:0005515 protein binding IPI 12762840
GO:0008017 microtubule binding TAS 12762840
GO:0048487 beta-tubulin binding IDA 12762840
genes like me logo Genes that share ontologies with UXT: view
genes like me logo Genes that share phenotypes with UXT: view

Animal Model Products

CRISPR Products

miRNA for UXT Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UXT
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UXT Gene

Localization for UXT Gene

Subcellular locations from UniProtKB/Swiss-Prot for UXT Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UXT gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (3)
  • Nucleus (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UXT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0000930 colocalizes_with gamma-tubulin complex IDA 16221885
GO:0005634 nucleus IEA,IDA 12762840
GO:0005737 cytoplasm IEA,IDA 21730289
GO:0005813 centrosome IDA 16221885
genes like me logo Genes that share ontologies with UXT: view

Pathways & Interactions for UXT Gene

genes like me logo Genes that share pathways with UXT: view

Pathways by source for UXT Gene

1 BioSystems pathway for UXT Gene

Gene Ontology (GO) - Biological Process for UXT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 21730289
GO:0000226 microtubule cytoskeleton organization IMP 16221885
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with UXT: view

No data available for SIGNOR curated interactions for UXT Gene

Drugs & Compounds for UXT Gene

No Compound Related Data Available

Transcripts for UXT Gene

Unigene Clusters for UXT Gene

Ubiquitously-expressed, prefoldin-like chaperone:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UXT
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for UXT Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - -
SP6: - -
SP7: -
SP8:

Relevant External Links for UXT Gene

GeneLoc Exon Structure for
UXT
ECgene alternative splicing isoforms for
UXT

Expression for UXT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UXT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UXT Gene

This gene is overexpressed in Fetal ovary (7.6), Colon (7.2), and Breast (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UXT Gene



Protein tissue co-expression partners for UXT Gene

NURSA nuclear receptor signaling pathways regulating expression of UXT Gene:

UXT

SOURCE GeneReport for Unigene cluster for UXT Gene:

Hs.172791

mRNA Expression by UniProt/SwissProt for UXT Gene:

Q9UBK9-UXT_HUMAN
Tissue specificity: Ubiquitous. Expressed in prostate epithelial cells. Overexpressed in a number of tumor tissues (PubMed:16221885). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus.

Evidence on tissue expression from TISSUES for UXT Gene

  • Blood(4.2)
genes like me logo Genes that share expression patterns with UXT: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UXT Gene

Orthologs for UXT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UXT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UXT 33 34
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia UXT 33 34
  • 94.66 (n)
dog
(Canis familiaris)
Mammalia UXT 33 34
  • 94.27 (n)
mouse
(Mus musculus)
Mammalia Uxt 33 16 34
  • 91.93 (n)
rat
(Rattus norvegicus)
Mammalia Uxt 33
  • 90.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UXT 34
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UXT 34
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii uxt 33 34
  • 63.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(2)35Cc 34
  • 27 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G26660 33
  • 47.31 (n)
rice
(Oryza sativa)
Liliopsida Os07g0595800 33
  • 49.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7146 34
  • 43 (a)
OneToOne
Species where no ortholog for UXT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UXT Gene

ENSEMBL:
Gene Tree for UXT (if available)
TreeFam:
Gene Tree for UXT (if available)

Paralogs for UXT Gene

No data available for Paralogs for UXT Gene

Variants for UXT Gene

Sequence variations from dbSNP and Humsavar for UXT Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000508259 -- 47,657,019(+) TGCTT(A/G)TTATG intron-variant, upstream-variant-2KB
rs1000944829 -- 47,656,362(+) GAGTG(A/T)CTACT intron-variant
rs1001210462 -- 47,655,802(+) CCCTC(A/G)TCTAT intron-variant
rs1001545882 -- 47,658,915(+) CTTAG(A/G)GGGCG nc-transcript-variant, reference, missense
rs1001766142 -- 47,656,156(+) GCATA(-/C)CCTTT intron-variant

Variation tolerance for UXT Gene

Residual Variation Intolerance Score: 35.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UXT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UXT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UXT Gene

Disorders for UXT Gene

Relevant External Links for UXT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UXT

No disorders were found for UXT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UXT Gene

Publications for UXT Gene

  1. UXT is a novel centrosomal protein essential for cell viability. (PMID: 16221885) Zhao H … Greene MI (Molecular biology of the cell 2005) 2 3 4 60
  2. Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue. (PMID: 10087202) Schroer A … Nothwang H (Genomics 1999) 2 3 4 60
  3. Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP. (PMID: 21730289) Mita P … Logan SK (Molecular and cellular biology 2011) 3 4 60
  4. UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation. (PMID: 17635584) McGilvray R … Bartholomew C (The FEBS journal 2007) 3 4 60
  5. UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome. (PMID: 17620405) Sun S … Wang C (The Journal of cell biology 2007) 3 4 60

Products for UXT Gene

Sources for UXT Gene

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