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Aliases for UXT Gene

Aliases for UXT Gene

  • Ubiquitously Expressed Prefoldin Like Chaperone 2 3 5
  • Ubiquitously-Expressed, Prefoldin-Like Chaperone 2 3
  • Androgen Receptor Trapped Clone 27 Protein 3 4
  • Ubiquitously Expressed Transcript Protein 3 4
  • SKP2-Associated Alpha PFD 1 2 3
  • ART-27 3 4
  • Androgen Receptor Trapped Clone 27 2
  • Ubiquitously-Expressed Transcript 2
  • STAP1 3

External Ids for UXT Gene

Previous GeneCards Identifiers for UXT Gene

  • GC0XM046313
  • GC0XM045771
  • GC0XM046557
  • GC0XM047267
  • GC0XM047396
  • GC0XM047511
  • GC0XM045223

Summaries for UXT Gene

Entrez Gene Summary for UXT Gene

  • The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for UXT Gene

UXT (Ubiquitously Expressed Prefoldin Like Chaperone) is a Protein Coding gene. Diseases associated with UXT include Amyotrophic Lateral Sclerosis Type 2. Among its related pathways are E2F transcription factor network. GO annotations related to this gene include chromatin binding and actin filament binding.

UniProtKB/Swiss-Prot for UXT Gene

  • Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region.

Gene Wiki entry for UXT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UXT Gene

Genomics for UXT Gene

Regulatory Elements for UXT Gene

Enhancers for UXT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UXT on UCSC Golden Path with GeneCards custom track

Promoters for UXT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UXT on UCSC Golden Path with GeneCards custom track

Genomic Location for UXT Gene

Chromosome:
X
Start:
47,651,792 bp from pter
End:
47,659,180 bp from pter
Size:
7,389 bases
Orientation:
Minus strand

Genomic View for UXT Gene

Genes around UXT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UXT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UXT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UXT Gene

Proteins for UXT Gene

  • Protein details for UXT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBK9-UXT_HUMAN
    Recommended name:
    Protein UXT
    Protein Accession:
    Q9UBK9
    Secondary Accessions:
    • B2R561
    • Q5JZG3
    • Q9Y6E5

    Protein attributes for UXT Gene

    Size:
    157 amino acids
    Molecular mass:
    18246 Da
    Quaternary structure:
    • Homohexamer. Interacts with LRPPRC. Interacts with AR N-terminus. In the nucleus interacts specifically with RELA and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation. Interacts with MECOM and URI1.
    SequenceCaution:
    • Sequence=AAD39840.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI42447.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for UXT Gene

Proteomics data for UXT Gene at MOPED

Post-translational modifications for UXT Gene

  • Ubiquitination at Lys 16, Lys 41, Lys 48, Lys 113, Lys 126, and Lys 154
  • Modification sites at PhosphoSitePlus

Other Protein References for UXT Gene

No data available for DME Specific Peptides for UXT Gene

Domains & Families for UXT Gene

Gene Families for UXT Gene

Suggested Antigen Peptide Sequences for UXT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBK9

UniProtKB/Swiss-Prot:

UXT_HUMAN :
  • Belongs to the UXT family.
Family:
  • Belongs to the UXT family.
genes like me logo Genes that share domains with UXT: view

Function for UXT Gene

Molecular function for UXT Gene

GENATLAS Biochemistry:
transcript with no homology to any known gene,ubiquitously expressed,abundantly expressed in tumor tissue
UniProtKB/Swiss-Prot Function:
Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region.

Gene Ontology (GO) - Molecular Function for UXT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 NOT actin filament binding IDA 12762840
genes like me logo Genes that share ontologies with UXT: view
genes like me logo Genes that share phenotypes with UXT: view

Animal Model Products

miRNA for UXT Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UXT Gene

Localization for UXT Gene

Subcellular locations from UniProtKB/Swiss-Prot for UXT Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UXT Gene COMPARTMENTS Subcellular localization image for UXT gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UXT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12762840
genes like me logo Genes that share ontologies with UXT: view

Pathways & Interactions for UXT Gene

genes like me logo Genes that share pathways with UXT: view

Pathways by source for UXT Gene

1 BioSystems pathway for UXT Gene

Gene Ontology (GO) - Biological Process for UXT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 21730289
GO:0000226 microtubule cytoskeleton organization IMP 16221885
genes like me logo Genes that share ontologies with UXT: view

No data available for SIGNOR curated interactions for UXT Gene

Drugs & Compounds for UXT Gene

No Compound Related Data Available

Transcripts for UXT Gene

Unigene Clusters for UXT Gene

Ubiquitously-expressed, prefoldin-like chaperone:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UXT Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - -
SP6: - -
SP7: -
SP8:

Relevant External Links for UXT Gene

GeneLoc Exon Structure for
UXT
ECgene alternative splicing isoforms for
UXT

Expression for UXT Gene

mRNA expression in normal human tissues for UXT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UXT Gene

This gene is overexpressed in Fetal ovary (7.6), Colon (7.2), and Breast (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UXT Gene



SOURCE GeneReport for Unigene cluster for UXT Gene Hs.172791

mRNA Expression by UniProt/SwissProt for UXT Gene

Q9UBK9-UXT_HUMAN
Tissue specificity: Ubiquitous. Expressed in prostate epithelial cells. Overexpressed in a number of tumor tissues (PubMed:16221885). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus.
genes like me logo Genes that share expression patterns with UXT: view

Protein tissue co-expression partners for UXT Gene

Primer Products

No data available for mRNA differential expression in normal tissues for UXT Gene

Orthologs for UXT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UXT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UXT 35
  • 94.66 (n)
  • 94.87 (a)
UXT 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UXT 35
  • 94.27 (n)
  • 94.27 (a)
UXT 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uxt 35
  • 91.93 (n)
  • 91.08 (a)
Uxt 16
Uxt 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UXT 35
  • 99.72 (n)
  • 99.16 (a)
UXT 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uxt 35
  • 90.87 (n)
  • 89.17 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia UXT 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UXT 36
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii uxt 35
  • 63.07 (n)
  • 64.03 (a)
uxt 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta l(2)35Cc 36
  • 27 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G26660 35
  • 47.31 (n)
  • 33.06 (a)
rice
(Oryza sativa)
Liliopsida Os07g0595800 35
  • 49.36 (n)
  • 37.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7146 36
  • 43 (a)
OneToOne
Species with no ortholog for UXT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UXT Gene

ENSEMBL:
Gene Tree for UXT (if available)
TreeFam:
Gene Tree for UXT (if available)

Paralogs for UXT Gene

No data available for Paralogs for UXT Gene

Variants for UXT Gene

Sequence variations from dbSNP and Humsavar for UXT Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs748379664 -- 47,656,817(+) AATTC(C/T)AACAG intron-variant
rs749120318 -- 47,654,718(+) TTAAA(A/G)GACAG intron-variant
rs749276033 -- 47,653,836(+) GGAAC(C/T)TGAGG intron-variant
rs749580534 -- 47,660,976(+) CTCCC(A/G)CCTAA upstream-variant-2KB
rs4824629 -- 47,655,674(+) AGCAT(A/G)CCAGg intron-variant

Variation tolerance for UXT Gene

Residual Variation Intolerance Score: 35.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.70% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for UXT Gene

Disorders for UXT Gene

MalaCards: The human disease database

(1) MalaCards diseases for UXT Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis type 2
  • amyotrophic lateral sclerosis 2, juvenile
- elite association - COSMIC cancer census association via MalaCards
Search UXT in MalaCards View complete list of genes associated with diseases

Relevant External Links for UXT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UXT
genes like me logo Genes that share disorders with UXT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UXT Gene

Publications for UXT Gene

  1. UXT is a novel centrosomal protein essential for cell viability. (PMID: 16221885) Zhao H. … Greene M.I. (Mol. Biol. Cell 2005) 2 3 4 67
  2. ART-27, an androgen receptor coactivator regulated in prostate development and cancer. (PMID: 14711828) Taneja S.S. … Logan S.K. (J. Biol. Chem. 2004) 3 23
  3. Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells. (PMID: 12762840) Liu L. … McKeehan W.L. (In Vitro Cell. Dev. Biol. Anim. 2002) 3 23
  4. Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue. (PMID: 10087202) Schroer A. … Nothwang H.G. (Genomics 1999) 2 3
  5. Ubiquitously expressed transcript is a novel interacting protein of protein inhibitor of activated signal transducer and activator of transcription 2. (PMID: 25434787) Kong X. … Zheng Y. (Mol Med Rep 2015) 3

Products for UXT Gene

Sources for UXT Gene

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