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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UXT Gene

protein-coding   GIFtS: 53
GCID: GC0XM047511

ubiquitously-expressed, prefoldin-like chaperone

(Previous name: ubiquitously-expressed transcript )
 Explore 7 diseases affiliated with
UXT via our new
 Human Malady Compendium 
Biological research products
for UXT
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ubiquitously-Expressed, Prefoldin-Like Chaperone1 2     Ubiquitously Expressed Transcript Protein2 3
ART-271 2 3     Ubiquitously-Expressed Transcript1
STAP11 2     Protein UXT2
Androgen Receptor Trapped Clone 27 Protein2 3     SKP2-Associated Alpha PFD 12

External Ids:    HGNC: 126411   Entrez Gene: 84092   Ensembl: ENSG000001267567   OMIM: 3002345   UniProtKB: Q9UBK93   

Export aliases for UXT gene to outside databases

Previous GC identifers: GC0XM046313 GC0XM045771 GC0XM046557 GC0XM047267 GC0XM047396 GC0XM045223


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UXT:
The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and
also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in
tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
(provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: UXT_HUMAN, Q9UBK9
Function: Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen
receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating
receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC,
a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome
remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria
and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that
promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405).
Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological
activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1,
associates with chromatin to the NKX3-1 promoter region

Gene Wiki entry for UXT


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_079573.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UXT gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUXT promoter sequence
   Search SABiosciences Chromatin IP Primers for UXT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UXT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23-p11.22   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23-p11.22

UXT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UXT gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM047511:  view genomic region     (about GC identifiers)

Start:
47,511,195 bp from pter      End:
47,518,560 bp from pter
Size:
7,366 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UXT_HUMAN, Q9UBK9 (See protein sequence)
Recommended Name: Protein UXT  
Size: 157 amino acids; 18246 Da
Subunit: Homohexamer. Interacts with LRPPRC. Interacts with AR N-terminus. In the nucleus interacts specifically with
RELA and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation.
Interacts with MECOM and URI1
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Nucleus
Sequence caution: Sequence=AAD39840.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAI42447.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2R561 Q5JZG3 Q9Y6E5

Explore the universe of human proteins at neXtProt for UXT: NX_Q9UBK9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UBK9

  • UXT Protein expression data from MOPED and PaxDb:    About this image 
    UXT Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_004173.1  NP_705582.1  

    ENSEMBL proteins: 
     ENSP00000327797   ENSP00000337393  

    Human Recombinant Protein Products for UXT: 
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    Novus Biologicals UXT Proteins
    Novus Biologicals UXT Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UXT

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000930colocalizes with gamma-tubulin complex IDA16221885
    GO:0005634nucleus IDA12762840
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA16221885
    GO:0005856cytoskeleton IDA12762840

    UXT for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for UXT


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    UXT for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009053 Prefoldin
     IPR004127 Prefoldin_subunit
     IPR003994 PFD_UXT

    Graphical View of Domain Structure for InterPro Entry Q9UBK9

    ProtoNet protein and cluster: Q9UBK9

    2 Blocks protein families:
    IPB003994 Ubiquitously expressed transcript protein signature
    IPB004127 Putative prefoldin chaperone


    UniProtKB/Swiss-Prot: UXT_HUMAN, Q9UBK9
    Similarity: Belongs to the UXT family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UXT_HUMAN, Q9UBK9
    Function: Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen
    receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating
    receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC,
    a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome
    remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria
    and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that
    promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405).
    Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological
    activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1,
    associates with chromatin to the NKX3-1 promoter region

         Genatlas biochemistry entry for UXT:
    transcript with no homology to any known gene,ubiquitously expressed,abundantly expressed in tumor tissue

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001106RNA polymerase II transcription corepressor activity IDA--
    GO:0003682chromatin binding IDA--
    GO:0005515protein binding IPI17635584
    GO:0008017microtubule binding TAS12762840
    GO:0048487beta-tubulin binding IDA12762840
         
    UXT for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UXT:
     Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for UXT 

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UXT
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate UXT:
    hsa-miR-3910 hsa-miR-3155 hsa-miR-3155b hsa-miR-484
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UXT (see all 7)
    OriGene shRNA RFP: UXT
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UXT
    Sirion Biotech Custom design and validation of potent shRNA sequences against UXT 

    Gene Editing
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    Clone
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    Sirion Biotech Customized inducible overexpressing cell line services for UXT

    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UXT


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1E2F transcription factor network
    E2F transcription factor network1.00


    1 BioSystems Pathway for UXT 
        E2F transcription factor network


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UXT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for UXT (Q9UBK91, 2, 3 ENSP000003373934) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM63Q969Q12, 3, ENSP000003633904MINT-6503530 I2D: score=1 STRING: ENSP00000363390
    MAP3K3Q997592, 3MINT-48473 I2D: score=2 
    MECOMQ031121, 3, ENSP000002646744EBI-357355,EBI-1384862 I2D: score=1 STRING: ENSP00000264674
    RELAQ042061, 3, ENSP000003842734EBI-357355,EBI-73886 I2D: score=1 STRING: ENSP00000384273
    SMURF2Q9HAU42, 3, ENSP000002624354MINT-6503840 I2D: score=1 STRING: ENSP00000262435
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0000226microtubule cytoskeleton organization IMP16221885
    GO:0006457protein folding IEA--
    GO:0047497mitochondrion transport along microtubule TAS12762840
    GO:0051297centrosome organization IMP16221885

    UXT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UXT
    Search CenterWatch for drugs/clinical trials and news about UXT 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UXT gene (2 alternative transcripts): 
    NM_004182.3  NM_153477.2  

    Unigene Cluster for UXT:

    Ubiquitously-expressed, prefoldin-like chaperone
    Hs.172791  [show with all ESTs]
    Unigene Representative Sequence: BU561078
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333119(uc022bvp.1 uc004din.3) ENST00000460840 ENST00000485641
    ENST00000335890(uc004dim.3) ENST00000376964

    miRNA
    Products:
         
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UXT
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate UXT:
    hsa-miR-3910 hsa-miR-3155 hsa-miR-3155b hsa-miR-484
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UXT (see all 7)
    OriGene shRNA RFP: UXT
    OriGene siRNA: UXT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UXT
    Sirion Biotech Custom design and validation of potent shRNA sequences against UXT 
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UXT (see all 5)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): UXT (NM_153477)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UXT 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UXT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UXT

    Additional cDNA sequence: 

    AF083241.1 AF083242.1 AF092737.1 AK223320.1 AK312072.1 BC000720.1 BC008890.1 NR_045559.1 
    NR_045560.1 

    11 DOTS entries:

    DT.454992  DT.95370160  DT.95341621  DT.86846522  DT.95370159  DT.100884517  DT.92428929  DT.95370162 
    DT.121282007  DT.99950843  DT.91858227 

    24/155 AceView cDNA sequences (see all 155):

    AI081163 BI833250 BE731794 F37009 AI086235 AF083241 AI094698 AI591039 
    AA804193 NM_004182 NM_153477 AF092737 AU102649 BX952409 BC000720 AA918417 
    CB125994 CB110096 R96465 CA776395 BM756469 AA316678 AA857524 BQ879839 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for UXT (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8
    SP1:                                -                 -                 -     -     -               
    SP2:                                                  -                 -     -     -               
    SP3:                                -           -     -                 -     -     -               
    SP4:                    -           -                                                               
    SP5:                                -                 -                                             


    ECgene alternative splicing isoforms for UXT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UXT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGCTAGAGG
    UXT Expression
    About this image
    See UXT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UXT

    SOURCE GeneReport for Unigene cluster: Hs.172791

    UniProtKB/Swiss-Prot: UXT_HUMAN, Q9UBK9
    Tissue specificity: Ubiquitous. Expressed in prostate epithelial cells. Overexpressed in a number of tumor tissues
    (PubMed:16221885). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral
    blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus

        SABiosciences Expression via Pathway-Focused PCR Array including UXT: 
              Mitochondria in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UXT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UXT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UXT gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uxt1 , 5 ubiquitously expressed transcript1, 5 91.93(n)1
    91.08(a)1
      X (16.46 cM)5
    222941  NM_013840.31  NP_038868.21 
     209417225 
    lizard
    (Anolis carolinensis)
    Reptilia UXT6
    --
    63(a)
    1 ↔ 1
    2(68531234-68538159)
    zebrafish
    (Danio rerio)
    Actinopterygii uxt1 ubiquitously-expressed transcript 63.07(n)
    64.03(a)
      447933  NM_001004671.1  NP_001004671.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)35Cc6
    lethal (2) 35Cc
    25(a)
    1 ↔ 1
    2L(15256560-15257642)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G266601 Prefoldin chaperone subunit family protein 47.15(n)
    33.33(a)
      839206  NM_102428.3  NP_564253.2 
    rice
    (Oryza sativa)
    Liliopsida Os07g05958001 hypothetical protein 49.36(n)
    37.4(a)
      4343790  NM_001066703.1  NP_001060168.1 


    ENSEMBL Gene Tree for UXT (if available)
    TreeFam Gene Tree for UXT (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/90 NCBI SNPs in UXT are shown (see all 90    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105693431,2
    C--47512168(+) ctgtg-/TGaagcc 4 -- int10--------
    rs1918768981,2
    --47512247(+) CAGCAA/GAGGAA 4 -- int10--------
    rs1402518931,2
    --47512251(+) AGAGGA/TAGGAG 4 -- int10--------
    rs1836998211,2
    --47512375(+) ATGAAA/GAATGA 4 -- int10--------
    rs1882254701,2
    --47512401(+) TGCCTA/G/TATGGT 4 -- int10--------
    rs1453096931,2
    --47512473(+) GCAGTA/GAGGTC 4 -- int10--------
    rs1904171901,2
    --47512690(+) AAAGTA/GGTATG 4 -- int10--------
    rs1825860251,2
    --47512811(+) AAGTGC/TCTCAT 4 -- int10--------
    rs1869183761,2
    --47512846(+) CCTGAA/CCTTCC 4 -- int10--------
    rs1449575261,2
    --47512870(+) TCCTCA/CCCTAA 4 -- int10--------

    HapMap Linkage Disequilibrium report for UXT (47511195 - 47518560 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for UXT: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    UXT for disorders           About GeneDecksing

    OMIM gene information: 300234    OMIM disorders: --

    7 diseases for UXT:    About MalaCards
    amyotrophic lateral sclerosis    lateral sclerosis    down syndrome    thyroiditis
    malaria    prostatitis    prostate cancer


    Export disorders for UXT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UXT gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with UXT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. UXT is a novel centrosomal protein essential for cell viability. (PubMed id 16221885)1, 2, 3 Zhao H.... Greene M.I. (2005)
    2. Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue. (PubMed id 10087202)1, 2, 3 Schroer A.... Nothwang H.G. (1999)
    3. Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP. (PubMed id 21730289)1, 2 Mita P.... Logan S.K. (2011)
    4. UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome. (PubMed id 17620405)1, 2 Sun S.... Wang C. (2007)
    5. UXT (Ubiquitously Expressed Transcript) causes mitochondrial aggregation. (PubMed id 17554592)1, 2 Moss T.N.... Liu L. (2007)
    6. UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation. (PubMed id 17635584)1, 2 McGilvray R.... Bartholomew C. (2007)
    7. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus. (PubMed id 11854421)1, 2 Markus S.M....Garabedian M.J. (2002)
    10. Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity. (PubMed id 11827465)1, 2 Liu L. and McKeehan W.L. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8409 HGNC: 12641 AceView: UXT Ensembl:ENSG00000126756 euGenes: HUgn8409
    ECgene: UXT H-InvDB: UXT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UXT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UXT Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UXT gene:
    Search GeneIP for patents involving UXT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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