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UXT Gene

protein-coding   GIFtS: 58
GCID: GC0XM047511

Ubiquitously-Expressed, Prefoldin-Like Chaperone

(Previous name: ubiquitously-expressed transcript)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ubiquitously-Expressed, Prefoldin-Like Chaperone1 2     Androgen Receptor Trapped Clone 271
SKP2-Associated Alpha PFD 11 2     Ubiquitously-Expressed Transcript1
Androgen Receptor Trapped Clone 27 Protein2 3     STAP12
Ubiquitously Expressed Transcript Protein2 3     Protein UXT2
ART-272 3     

External Ids:    HGNC: 126411   Entrez Gene: 84092   Ensembl: ENSG000001267567   OMIM: 3002345   UniProtKB: Q9UBK93   
ORGUL members:         

Export aliases for UXT gene to outside databases

Previous GC identifers: GC0XM046313 GC0XM045771 GC0XM046557 GC0XM047267 GC0XM047396 GC0XM045223


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UXT Gene:
The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription,
and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a
role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed
for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for UXT Gene:
UXT (ubiquitously-expressed, prefoldin-like chaperone) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding and chromatin binding.

UniProtKB/Swiss-Prot: UXT_HUMAN, Q9UBK9
Function: Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate
androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating
receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated
LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with
chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation
of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a
nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear
function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and
inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM
(PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region

Gene Wiki entry for UXT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the UXT gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUXT promoter sequence
   Search Chromatin IP Primers for UXT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UXT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23-p11.22   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23-p11.22

UXT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UXT gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM047511:  view genomic region     (about GC identifiers)

Start:
47,511,195 bp from pter      End:
47,518,560 bp from pter
Size:
7,366 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UXT_HUMAN, Q9UBK9 (See protein sequence)
Recommended Name: Protein UXT  
Size: 157 amino acids; 18246 Da
Subunit: Homohexamer. Interacts with LRPPRC. Interacts with AR N-terminus. In the nucleus interacts specifically
with RELA and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon
stimulation. Interacts with MECOM and URI1
Sequence caution: Sequence=AAD39840.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAI42447.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2R561 Q5JZG3 Q9Y6E5

Explore the universe of human proteins at neXtProt for UXT: NX_Q9UBK9

Explore proteomics data for UXT at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys16, Lys41, Lys48, Lys113, Lys126, Lys154
  • Modification sites at PhosphoSitePlus

  • See UXT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004173.1  NP_705582.1  

    ENSEMBL proteins: 
     ENSP00000327797   ENSP00000473785   ENSP00000337393  

    UXT Human Recombinant Protein Products:

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    Novus Biologicals UXT Proteins
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    Cloud-Clone Corp. Proteins for UXT

     
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    UXT Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR004127 Prefoldin_subunit_alpha
     IPR003994 PFD_UXT
     IPR009053 Prefoldin

    Graphical View of Domain Structure for InterPro Entry Q9UBK9

    ProtoNet protein and cluster: Q9UBK9

    2 Blocks protein domains:
    IPB003994 Ubiquitously expressed transcript protein signature
    IPB004127 Putative prefoldin chaperone


    UniProtKB/Swiss-Prot: UXT_HUMAN, Q9UBK9
    Similarity: Belongs to the UXT family


    Find genes that share domains with UXT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UXT_HUMAN, Q9UBK9
    Function: Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate
    androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating
    receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated
    LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with
    chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation
    of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a
    nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear
    function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and
    inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM
    (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region

         Genatlas biochemistry entry for UXT:
    transcript with no homology to any known gene,ubiquitously expressed,abundantly expressed in tumor tissue

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001106RNA polymerase II transcription corepressor activity IDA--
    GO:0003682chromatin binding IDA--
    GO:0005515protein binding IPI12762840
    GO:0008017microtubule binding TAS12762840
    GO:0048487beta-tubulin binding IDA12762840
         
    Find genes that share ontologies with UXT           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UXT:
     Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UXT
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UXT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UXT

    miRNA
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    miRTarBase miRNAs that target UXT:
    hsa-mir-30c-5p (MIRT047919), hsa-mir-26b-5p (MIRT029970), hsa-mir-149-5p (MIRT045646), hsa-mir-16-5p (MIRT031877)

    Block miRNA regulation of human, mouse, rat UXT using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate UXT:
    hsa-miR-3910 hsa-miR-3155 hsa-miR-3155b hsa-miR-484
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UXT

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): UXT (NM_153477)
    Sino Biological Human cDNA Clone for UXT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UXT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UXT

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UXT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UXT_HUMAN, Q9UBK9: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center,
    centrosome. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000930colocalizes with gamma-tubulin complex IDA16221885
    GO:0005634nucleus IDA12762840
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA16221885
    GO:0005815microtubule organizing center IDA--

    Find genes that share ontologies with UXT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UXT About    
    See pathways by source

    SuperPathContained pathways About
    1E2F transcription factor network
    E2F transcription factor network


    1 BioSystems Pathway for UXT
        E2F transcription factor network



        Pathway & Disease-focused RT2 Profiler PCR Array including UXT: 
              Mitochondria in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UXT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UXT (Q9UBK91, 2, 3 ENSP000003373934) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3, ENSP000003549274MINT-48473 I2D: score=2 STRING: ENSP00000354927
    TRIM63Q969Q12, 3, ENSP000003633904MINT-6503530 I2D: score=1 STRING: ENSP00000363390
    MECOMQ031121, 3, ENSP000002646744EBI-357355,EBI-1384862 I2D: score=1 STRING: ENSP00000264674
    RELAQ042061, 3, ENSP000003842734EBI-357355,EBI-73886 I2D: score=1 STRING: ENSP00000384273
    SMURF2Q9HAU42, 3, ENSP000002624354MINT-6503840 I2D: score=1 STRING: ENSP00000262435
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0000226microtubule cytoskeleton organization IMP16221885
    GO:0006457protein folding IEA--
    GO:0047497mitochondrion transport along microtubule TAS12762840
    GO:0051297centrosome organization IMP16221885

    Find genes that share ontologies with UXT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UXT



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UXT gene (2 alternative transcripts): 
    NM_004182.3  NM_153477.2  

    Unigene Cluster for UXT:

    Ubiquitously-expressed, prefoldin-like chaperone
    Hs.172791  [show with all ESTs]
    Unigene Representative Sequence: BU561078
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333119(uc022bvp.1 uc004din.3) ENST00000460840 ENST00000485641
    ENST00000335890(uc004dim.3) ENST00000376964
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UXT using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate UXT:
    hsa-miR-3910 hsa-miR-3155 hsa-miR-3155b hsa-miR-484
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UXT
    Predesigned siRNA for gene silencing in human, mouse, rat UXT
    Clone
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    OriGene ORF clones in mouse, rat for UXT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UXT (NM_153477)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UXT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UXT
    Primer
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    OriGene qPCR primer pairs and template standards for UXT
    OriGene qSTAR qPCR primer pairs in human, mouse for UXT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UXT
      QuantiTect SYBR Green Assays in human, mouse, rat UXT
      QuantiFast Probe-based Assays in human, mouse, rat UXT

    Additional mRNA sequence: 

    AF083241.1 AF083242.1 AF092737.1 AK223320.1 AK312072.1 BC000720.1 BC008890.1 NR_045559.1 
    NR_045560.1 

    11 DOTS entries:

    DT.454992  DT.95370160  DT.95341621  DT.86846522  DT.95370159  DT.100884517  DT.92428929  DT.95370162 
    DT.121282007  DT.99950843  DT.91858227 

    Selected AceView cDNA sequences (see all 155):

    AA292902 AI591039 AI493513 BI833250 AI081163 AI094698 BE731794 AF083241 
    AI358636 AI086235 AA918417 BC000720 BM756469 AA316678 AJ708151 R96465 
    BQ681820 AA804193 AF092737 NM_153477 CA776395 CB125994 BX952409 BU839213 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UXT (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8
    SP1:                                -                 -                 -     -     -               
    SP2:                                                  -                 -     -     -               
    SP3:                                -           -     -                 -     -     -               
    SP4:                    -           -                                                               
    SP5:                                -                 -                                             


    ECgene alternative splicing isoforms for UXT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UXT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCTAGAGG
    UXT Expression
    About this image


    UXT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Liver (Hepatobiliary System)
    UXT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UXT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.172791

    UniProtKB/Swiss-Prot: UXT_HUMAN, Q9UBK9
    Tissue specificity: Ubiquitous. Expressed in prostate epithelial cells. Overexpressed in a number of tumor tissues
    (PubMed:16221885). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland,
    peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus

        Pathway & Disease-focused RT2 Profiler PCR Array including UXT: 
              Mitochondria in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for UXT
    OriGene qSTAR qPCR primer pairs in human, mouse for UXT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UXT
    QuantiTect SYBR Green Assays in human, mouse, rat UXT
    QuantiFast Probe-based Assays in human, mouse, rat UXT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UXT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UXT gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uxt1 , 5 ubiquitously expressed transcript1, 5 91.93(n)1
    91.08(a)1
      X (16.46 cM)5
    222941  NM_013840.31  NP_038868.21 
     209417225 
    lizard
    (Anolis carolinensis)
    Reptilia UXT6
    ubiquitously-expressed, prefoldin-like chaperone
    63(a)
    1 ↔ 1
    2(68531116-68538190)
    zebrafish
    (Danio rerio)
    Actinopterygii uxt1 ubiquitously-expressed transcript 63.07(n)
    64.03(a)
      447933  NM_001004671.1  NP_001004671.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)35Cc6
    lethal (2) 35Cc
    27(a)
    1 ↔ 1
    2L(15256560-15257642)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G266601 AT1G26660 47.31(n)
    33.06(a)
      839206  NM_102428.3  NP_564253.2 
    rice
    (Oryza sativa)
    Liliopsida Os07g05958001 Os07g0595800 49.36(n)
    37.4(a)
      4343790  NM_001066703.1  NP_001060168.1 


    ENSEMBL Gene Tree for UXT (if available)
    TreeFam Gene Tree for UXT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UXT (see all 55)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105693431,2
    C--47512168(+) ctgtg-/TGaagcc 4 -- int10--------
    rs1918768981,2
    --47512247(+) CAGCAA/GAGGAA 4 -- int10--------
    rs1402518931,2
    --47512251(+) AGAGGA/TAGGAG 4 -- int10--------
    rs1836998211,2
    --47512375(+) ATGAAA/GAATGA 4 -- int10--------
    rs1882254701,2
    --47512401(+) TGCCTA/G/TATGGT 4 -- int10--------
    rs1453096931,2
    --47512473(+) GCAGTA/GAGGTC 4 -- int10--------
    rs1904171901,2
    --47512690(+) AAAGTA/GGTATG 4 -- int10--------
    rs1825860251,2
    --47512811(+) AAGTGC/TCTCAT 4 -- int10--------
    rs1869183761,2
    --47512846(+) CCTGAA/CCTTCC 4 -- int10--------
    rs1449575261,2
    --47512870(+) TCCTCA/CCCTAA 4 -- int10--------

    HapMap Linkage Disequilibrium report for UXT (47511195 - 47518560 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for UXT: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UXT
    DNA2.0 Custom Variant and Variant Library Synthesis for UXT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300234    OMIM disorders: --


    Find genes that share disorders with UXT           About GenesLikeMe


    Export disorders for UXT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UXT gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with UXT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. UXT is a novel centrosomal protein essential for cell viability. (PubMed id 16221885)1, 2, 3 Zhao H.... Greene M.I. (Mol. Biol. Cell 2005)
    2. Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue. (PubMed id 10087202)1, 2, 3 Schroer A.... Nothwang H.G. (Genomics 1999)
    3. Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP. (PubMed id 21730289)1, 2 Mita P.... Logan S.K. (Mol. Cell. Biol. 2011)
    4. UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome. (PubMed id 17620405)1, 2 Sun S.... Wang C. (J. Cell Biol. 2007)
    5. UXT (Ubiquitously Expressed Transcript) causes mitochondrial aggregation. (PubMed id 17554592)1, 2 Moss T.N.... Liu L. (In Vitro Cell. Dev. Biol. Anim. 2007)
    6. UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation. (PubMed id 17635584)1, 2 McGilvray R.... Bartholomew C. (FEBS J. 2007)
    7. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus. (PubMed id 11854421)1, 2 Markus S.M.... Garabedian M.J. (Mol. Biol. Cell 2002)
    10. Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity. (PubMed id 11827465)1, 2 Liu L. and McKeehan W.L. (Genomics 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8409 HGNC: 12641 AceView: UXT Ensembl:ENSG00000126756 euGenes: HUgn8409
    ECgene: UXT H-InvDB: UXT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UXT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UXT Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UXT gene:
    Search GeneIP for patents involving UXT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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