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Aliases for UXS1 Gene

Aliases for UXS1 Gene

  • UDP-Glucuronate Decarboxylase 1 2 3 4
  • UGD 3 4 6
  • EC 4.1.1.35 4 64
  • UXS-1 3 4
  • Short Chain Dehydrogenase/Reductase Family 6E, Member 12 3
  • Short Chain Dehydrogenase/Reductase Family 6E 2
  • UDP-Glucuronic Acid Decarboxylase 1 3
  • Member 12 2
  • SDR6E1 3

External Ids for UXS1 Gene

Summaries for UXS1 Gene

Entrez Gene Summary for UXS1 Gene

  • This gene encodes an enzyme found in the perinuclear Golgi which catalyzes the synthesis of UDP-xylose used in glycosaminoglycan (GAG) synthesis on proteoglycans. The GAG chains are covalently attached to proteoglycans which participate in signaling pathways during development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for UXS1 Gene

UXS1 (UDP-Glucuronate Decarboxylase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Glucuronidation. GO annotations related to this gene include coenzyme binding and UDP-glucuronate decarboxylase activity. An important paralog of this gene is TGDS.

UniProtKB/Swiss-Prot for UXS1 Gene

  • Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis

Gene Wiki entry for UXS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UXS1 Gene

Genomics for UXS1 Gene

Genomic Location for UXS1 Gene

Start:
106,093,303 bp from pter
End:
106,194,339 bp from pter
Size:
101,037 bases
Orientation:
Minus strand

Genomic View for UXS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UXS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UXS1 Gene

Regulatory Elements for UXS1 Gene

Proteins for UXS1 Gene

  • Protein details for UXS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBZ7-UXS1_HUMAN
    Recommended name:
    UDP-glucuronic acid decarboxylase 1
    Protein Accession:
    Q8NBZ7
    Secondary Accessions:
    • Q8NBX3
    • Q9H5C2

    Protein attributes for UXS1 Gene

    Size:
    420 amino acids
    Molecular mass:
    47577 Da
    Cofactor:
    Name=NAD(+); Xref=ChEBI:CHEBI:57540;
    Quaternary structure:
    • Interacts with AKT1.

    Three dimensional structures from OCA and Proteopedia for UXS1 Gene

    Alternative splice isoforms for UXS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UXS1 Gene

Proteomics data for UXS1 Gene at MOPED

Post-translational modifications for UXS1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn316

Domains for UXS1 Gene

Gene Families for UXS1 Gene

HGNC:
  • SDRE :Short chain dehydrogenase/reductase superfamily / Extended SDR fold

Protein Domains for UXS1 Gene

UniProtKB/Swiss-Prot:

UXS1_HUMAN
Family:
  • Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.:
    • Q8NBZ7
genes like me logo Genes that share domains with UXS1: view

Function for UXS1 Gene

Molecular function for UXS1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-D-glucuronate = UDP-D-xylose + CO(2)
UniProtKB/Swiss-Prot Function: Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis

Enzyme Numbers (IUBMB) for UXS1 Gene

Gene Ontology (GO) - Molecular Function for UXS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor --
GO:0042803 protein homodimerization activity IDA 23656592
GO:0048040 UDP-glucuronate decarboxylase activity IDA 23072385
genes like me logo Genes that share ontologies with UXS1: view

Phenotypes for UXS1 Gene

genes like me logo Genes that share phenotypes with UXS1: view

Animal Models for UXS1 Gene

MGI Knock Outs for UXS1:

miRNA for UXS1 Gene

miRTarBase miRNAs that target UXS1

No data available for Transcription Factor Targeting and HOMER Transcription for UXS1 Gene

Localization for UXS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UXS1 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UXS1 Gene COMPARTMENTS Subcellular localization image for UXS1 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UXS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with UXS1: view

Pathways for UXS1 Gene

genes like me logo Genes that share pathways with UXS1: view

Pathways by source for UXS1 Gene

UniProtKB/Swiss-Prot Q8NBZ7-UXS1_HUMAN

  • Pathway: Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1

Gene Ontology (GO) - Biological Process for UXS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006694 steroid biosynthetic process --
GO:0008152 metabolic process --
GO:0009058 biosynthetic process --
GO:0033320 UDP-D-xylose biosynthetic process IEA --
GO:0051262 protein tetramerization IDA 23656592
genes like me logo Genes that share ontologies with UXS1: view

Compounds for UXS1 Gene

(5) HMDB Compounds for UXS1 Gene

Compound Synonyms Cas Number PubMed IDs
Carbon dioxide
  • Carbon oxide
124-38-9
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
UDP-D-Xylose
  • UDP-D-xylose
3616-06-6
Uridine diphosphate glucuronic acid
  • UDP glucuronate
2616-64-0
genes like me logo Genes that share compounds with UXS1: view

Transcripts for UXS1 Gene

Unigene Clusters for UXS1 Gene

UDP-glucuronate decarboxylase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UXS1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - -
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for UXS1 Gene

GeneLoc Exon Structure for
UXS1
ECgene alternative splicing isoforms for
UXS1

Expression for UXS1 Gene

mRNA expression in normal human tissues for UXS1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UXS1 Gene

SOURCE GeneReport for Unigene cluster for UXS1 Gene Hs.743389

genes like me logo Genes that share expressions with UXS1: view

Orthologs for UXS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UXS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UXS1 36
  • 99.44 (n)
  • 99.76 (a)
UXS1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UXS1 36
  • 88.41 (n)
  • 96.67 (a)
UXS1 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UXS1 36
  • 90.71 (n)
  • 97.95 (a)
UXS1 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uxs1 36
  • 89.13 (n)
  • 98.57 (a)
Uxs1 16
Uxs1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UXS1 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UXS1 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uxs1 36
  • 89.13 (n)
  • 97.14 (a)
chicken
(Gallus gallus)
Aves UXS1 36
  • 83.25 (n)
  • 94.52 (a)
UXS1 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UXS1 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8401 36
uxs1 36
  • 77.91 (n)
  • 90.02 (a)
zebrafish
(Danio rerio)
Actinopterygii uxs1 36
  • 77.1 (n)
  • 88.11 (a)
uxs1 37
  • 88 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004268 36
  • 64.35 (n)
  • 70.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7979 36
  • 62.46 (n)
  • 71.15 (a)
CG7979 37
  • 57 (a)
OneToOne
CG7979 38
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea sqv-1 36
  • 62.02 (n)
  • 67.73 (a)
sqv-1 37
  • 51 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GAL10 37
  • 10 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.729 36
soybean
(Glycine max)
eudicotyledons Gma.6843 36
thale cress
(Arabidopsis thaliana)
eudicotyledons UXS5 36
  • 62.7 (n)
  • 63.99 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.942 36
corn
(Zea mays)
Liliopsida Zm.730 36
rice
(Oryza sativa)
Liliopsida Os03g0278000 36
  • 59.53 (n)
  • 63.26 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.23697 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10399 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 66 (a)
OneToOne
Species with no ortholog for UXS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UXS1 Gene

ENSEMBL:
Gene Tree for UXS1 (if available)
TreeFam:
Gene Tree for UXS1 (if available)

Paralogs for UXS1 Gene

Paralogs for UXS1 Gene

Selected SIMAP similar genes for UXS1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with UXS1: view

Variants for UXS1 Gene

Sequence variations from dbSNP and Humsavar for UXS1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1991 -- 106,094,084(-) TAATC(A/G)GTACA reference, missense, nc-transcript-variant, utr-variant-3-prime
rs716373 -- 106,179,030(+) TCATG(C/T)TACCT intron-variant
rs725216 -- 106,105,489(-) CAAGA(C/T)GGTCT intron-variant
rs725217 -- 106,105,676(-) ACCTC(A/G)CATCG intron-variant
rs737101 -- 106,116,089(+) TGAGA(C/T)GTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UXS1 Gene

Variant ID Type Subtype PubMed ID
nsv524810 CNV Loss 19592680

Relevant External Links for UXS1 Gene

HapMap Linkage Disequilibrium report
UXS1

Disorders for UXS1 Gene

Relevant External Links for UXS1

Genetic Association Database (GAD)
UXS1
Human Genome Epidemiology (HuGE) Navigator
UXS1
genes like me logo Genes that share disorders with UXS1: view

No data available for UniProtKB/Swiss-Prot for UXS1 Gene

Publications for UXS1 Gene

  1. The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide- sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development. (PMID: 12391314) Hwang H.-Y. … Horvitz H.R. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for UXS1 Gene

  • Addgene plasmids for UXS1

Sources for UXS1 Gene

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