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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UVRAG Gene

protein-coding GIFtS: 59
GCID: GC11P075526

UV radiation resistance associated

(Previous name: UV radiation resistance associated gene )

Explore 12 diseases affiliated with
UVRAG via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
UV Radiation Resistance Associated¹ ²		DHTX²
VPS38¹ ²		Beclin 1 Binding Protein²
P63¹		Disrupted In Heterotaxy²
UV Radiation Resistance Associated Gene¹		UV Radiation Resistance-Associated Gene Protein²

External Ids:	HGNC: 12640¹	Entrez Gene: 7405²	Ensembl: ENSG00000198382⁷	OMIM: 602493⁵	UniProtKB: Q9P2Y5³

Export aliases for UVRAG gene to outside databases

Previous GC identifers: GC11P077853 GC11P077065 GC11P075748 GC11P075252 GC11P075203 GC11P071822

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UVRAG:

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a

C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation

and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with

left-right axis malformation and mutations in this gene have been associated with colon cancer. (provided by RefSeq,

Jul 2008)

Gene Wiki entry for UVRAG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UVRAG gene promoter:
E2F-3a E2F-4 Elk-1 E2F-5 Pax-5 E2F-2 Meis-1b E2F-1 E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UVRAG promoter sequence

Search SABiosciences Chromatin IP Primers for UVRAG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UVRAG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5 Ensembl cytogenetic band: 11q13.5 HGNC cytogenetic band: 11q13

UVRAG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UVRAG gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P075526: view genomic region (about GC identifiers)

Start:	75,526,212 bp from pter	End:	75,855,282 bp from pter
Size:	329,071 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UVRAG_HUMAN, Q9P2Y5 (See protein sequence)

Recommended Name: UV radiation resistance-associated gene protein

Size: 699 amino acids; 78151 Da

Subunit: Forms a complex with BECN1, PIK3C3 and PIK3R4. A subpopulation of these complexes also harbor

KIAA0226/Rubicon. UVRAG-containing complexes never including ATG14, both forming mutually exclusive complexes with

BECN1 through direct competition. Directly interacts with FEZ1 and SCOC. The interaction with SCOC is reduced by amino

acid starvation, but the complex is stabilized in the presence of FEZ1

Subcellular location: Late endosome. Lysosome. Early endosome. Note=Colocalizes with RAB9-positive compartments

involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is

only partial

Sequence caution: Sequence=CAA67507.1; Type=Erroneous gene model prediction;

Secondary accessions: O00392

Explore the universe of human proteins at neXtProt for UVRAG: NX_Q9P2Y5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P2Y5

UVRAG Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003360.2

ENSEMBL proteins:

ENSP00000348455 ENSP00000436039 ENSP00000433613 ENSP00000431256 ENSP00000434082

ENSP00000436270 ENSP00000433414 ENSP00000438041 ENSP00000439016

Human Recombinant Protein Products:

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	Novus Biologicals UVRAG Proteins Novus Biologicals UVRAG Lysates
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for UVRAG

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	9169138
GO:0005764	lysosome	IDA	19270696
GO:0005769	early endosome	IDA	19270696
GO:0005770	late endosome	IDA	19270696
GO:0043234	protein complex	IEA	--

UVRAG for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for UVRAG

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UVRAG for domains About GeneDecksing

3 InterPro domains/families:

IPR008973 C2_Ca/lipid-bd_dom_CaLB

IPR018791 UV_resistance/autophagy_Atg14

IPR000008 C2_Ca-dep

Graphical View of Domain Structure for InterPro Entry Q9P2Y5

ProtoNet protein and cluster: Q9P2Y5

1 Blocks protein family: IPB000008 C2 domain

UniProtKB/Swiss-Prot: UVRAG_HUMAN, Q9P2Y5

Similarity: Contains 1 C2 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for UVRAG:

UV radiation resistance-associated gene

miRNA Products:		OriGene 3'-UTR Clone: UVRAG Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UVRAG
		8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate UVRAG (see all 84):
		hsa-miR-582-3p hsa-miR-549 hsa-miR-642a hsa-miR-520e hsa-miR-3921 hsa-miR-519a hsa-miR-3916 hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: UVRAG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UVRAG (see all 7) OriGene shRNA RFP: UVRAG OriGene siRNA: UVRAG
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for UVRAG

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UVRAG

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0017124	SH3 domain binding	IEA	--

UVRAG for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for UVRAG:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptosis and Autophagy

Apoptosis and Autophagy

1.00

Senescence and Autophagy

Senescence and Autophagy

1.00

DNA Damage

DNA Damage

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Cell Signaling Technology (CST) Pathways for UVRAG

	Apoptosis and Autophagy
	DNA Damage

1 BioSystems Pathway for UVRAG

Senescence and Autophagy

UVRAG for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for UVRAG

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/410 Interacting proteins for UVRAG (Q9P2Y5^{2, 3} ENSP00000348455⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 410)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006281	DNA repair	TAS	9169138
GO:0010508	positive regulation of autophagy	IEA	--

UVRAG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UVRAG
Search CenterWatch for drugs/clinical trials and news about UVRAG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UVRAG gene:

NM_003369.3

Unigene Cluster for UVRAG:

UV radiation resistance associated

Hs.202470 [show with all ESTs]

Unigene Representative Sequence: NM_003369

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000356136(uc001oxc.3 uc010rrw.2 uc001oxd.3 uc010rrx.2 uc010rry.2)

ENST00000528420 ENST00000528264 ENST00000525872 ENST00000533454(uc009yuh.1)

ENST00000530501 ENST00000531818 ENST00000532130 ENST00000525183 ENST00000539288

ENST00000538870

miRNA Products:		OriGene 3'-UTR Clone: UVRAG Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UVRAG
		8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate UVRAG (see all 84):
		hsa-miR-582-3p hsa-miR-549 hsa-miR-642a hsa-miR-520e hsa-miR-3921 hsa-miR-519a hsa-miR-3916 hsa-miR-3148

		SwitchGear 3'UTR luciferase reporter plasmid: UVRAG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UVRAG (see all 7) OriGene shRNA RFP: UVRAG OriGene siRNA: UVRAG
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Additional cDNA sequence:

AB012958.1 AK095352.1 AK222772.1 AK291011.1 AK293782.1 AK296871.1 AK299978.1 AK311341.1

AK316133.1 BC013176.1 BC064837.1

10 DOTS entries:

DT.95367764 DT.117521 DT.100653986 DT.97817841 DT.100757186 DT.95367763 DT.95367765 DT.100690903

DT.40306109 DT.92068572

24/199 AceView cDNA sequences (see all 199):

CR608114 BQ030225 AI572184 AI741831 AA768419 AI634125 AI381854 BE675875

AA766088 BM805439 AA490501 AI638393 BX457352 CA432731 AA251482 BE222140

BF792353 BE073068 CA436692 BF514762 BF725350 CF528908 BU789313 BQ073155

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UVRAG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTATATAG

About this image

UVRAG expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See UVRAG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UVRAG

SOURCE GeneReport for Unigene cluster: Hs.202470

UniProtKB/Swiss-Prot: UVRAG_HUMAN, Q9P2Y5

Tissue specificity: Highly expressed in brain, lung, kidney and liver

SABiosciences Expression via Pathway-Focused PCR Array including UVRAG:

Autophagy in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UVRAG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for UVRAG gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Uvrag^{1 , 5}	UV radiation resistance associated gene^{1, 5}	85.58(n)¹ 88.54(a)¹		7 (53.92 cM)⁵ 78610¹ NM_178635.3¹ NP_848750.3¹ 98886743⁵
chicken (Gallus gallus)	Aves	UVRAG¹	UV radiation resistance associated gene	77.09(n) 81.94(a)		419091 NM_001030839.1 NP_001026010.1
lizard (Anolis carolinensis)	Reptilia	UVRAG⁶	--	80(a)	1 ↔ 1	GL343298.1(1349114-1435699)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.13743²	Transcribed sequences	73.15(n)		BX735008.1
zebrafish (Danio rerio)	Actinopterygii	BC045959.1²	--	75.87(n)		394044 BC045959.1
fruit fly (Drosophila melanogaster)	Insecta	Uvrag⁶	UV-resistance associated gene	18(a)	1 ↔ 1	2L(13286790-13289561)

ENSEMBL Gene Tree for UVRAG (if available)
TreeFam Gene Tree for UVRAG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1458837^1,2	C,F,A,H,	--	71821527(-)	`TACTCC/GTAGAC`	4	--	nc-transcript-variant		8		MN NS EA NA WA	604
rs11605654^1,2	H	--	71821659(+)	`CCTTCA/CCTGCa`	4	--	nc-transcript-variant		0	--	--	--	--
rs199993816^1,2	C	--	71821683(-)	`TCAGGA/TAATTT`	4	--	int¹		0	--	--	--	--
rs112052491^1,2		--	71821856(+)	`TTGGGA/GGCCCG`	4	--	int¹		2		CSA WA	119
rs59929010^1,2	C,	--	71822526(+)	`ACCCAG/CCTGGC`	4	--	nc-transcript-variant		1		WA	2
rs17134356^1,2	C,F,H,	--	71822942(+)	`GGGTCC/TCGCCC`	4	--	us2k¹		16		NA NS EA	1338
rs111669325^1,2	C,	--	71823098(+)	`CCTCTC/TGGGTG`	4	--	us2k¹		2		CSA WA	119
rs7118569^1,2	C,F,A,	--	71823234(+)	`GGCCCC/GGTCCC`	4	--	us2k¹ ese³		3		WA NA EA	358
rs11825050^1,2	C,F,H,	--	71823598(+)	`CGGCCC/AGAGGC`	4	--	us2k¹		1		WA	118
rs112646374^1,2	C,	--	71823614(+)	`CCCCCA/GACGCA`	4	--	us2k¹		2		WA	120

HapMap Linkage Disequilibrium report for UVRAG (75526212 - 75776212 bp, first 250kb of UVRAG)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for UVRAG
2 CNVs: 65997 75707

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UVRAG

DNA2.0 Custom Variant and Variant Library Synthesis for UVRAG

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

UVRAG for disorders About GeneDecksing

OMIM gene information: 602493 OMIM disorders: --

UniProtKB/Swiss-Prot: UVRAG_HUMAN, Q9P2Y5

Note=A chromosomal aberration involving UVRAG has been observed in a patient with heterotaxy (left-right axis

malformation). Inversion Inv(11)(q13.5;q25)

12 diseases for UVRAG: About MalaCards

left-right axis malformations xeroderma pigmentosum, group c xeroderma pigmentosum colon cancer

heterotaxy situs inversus ascending colon cancer cholecystolithiasis

vitiligo breast carcinoma carcinoma hepatitis

1 disease from the University of Copenhagen DISEASES database for UVRAG:

Ascending colon cancer

Human Genome Epidemiology (HuGE) Navigator: UVRAG (3 documents)

Export disorders for UVRAG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for UVRAG gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with UVRAG)

Utopia: connect your pdf to the dynamic
world of online information

Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. (PubMed id 18843052)^{1, 2, 3} Itakura E....Mizushima N. (2008)
Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus. (PubMed id 9169138)^{1, 2, 3} Perelman B.... Canaani D. (1997)
Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation. (PubMed id 10798355)^{1, 2, 9} Iida A.... Nakamura Y. (2000)
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. (PubMed id 19270696)^{1, 2} Matsunaga K....Yoshimori T. (2009)
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. (PubMed id 16799551)^{1, 3} Liang C....Jung J.U. (2006)
Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PubMed id 22354037)² McKnight N.C.... Tooze S.A. (2012)
Receptor signaling lymphocyte-activation molecule fami ly 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by r ecruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVR AG) complex. (PubMed id 22493499)¹ Ma C....Terhorst C. (2012)
Imperfect interface of Beclin1 coiled-coil domain regu lates homodimer and heterodimer formation with Atg14L and UVRAG. (PubMed id 22314358)¹ Li X....Zhao Y. (2012)
A dual role for UVRAG in maintaining chromosomal stabi lity independent of autophagy. (PubMed id 22542840)¹ Zhao Z....Liang C. (2012)
A critical role for UVRAG in apoptosis. (PubMed id 21606679)¹ Yin X....Tang D. (2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7405	HGNC: 12640	AceView: UVRAG	Ensembl:ENSG00000198382	euGenes: HUgn7405
ECgene: UVRAG	H-InvDB: UVRAG

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for UVRAG	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for UVRAG	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for UVRAG gene
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Patent Information for UVRAG gene:
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