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UVRAG Gene

protein-coding   GIFtS: 61
GCID: GC11P075526

UV Radiation Resistance Associated

(Previous name: UV radiation resistance associated gene)
  See UVRAG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UV Radiation Resistance Associated1 2     DHTX2
Beclin 1 Binding Protein1 2     VPS382
p632 3     Disrupted In Heterotaxy2
UV Radiation Resistance Associated Gene1     UV Radiation Resistance-Associated Gene Protein2

External Ids:    HGNC: 126401   Entrez Gene: 74052   Ensembl: ENSG000001983827   OMIM: 6024935   UniProtKB: Q9P2Y53   

Export aliases for UVRAG gene to outside databases

Previous GC identifers: GC11P077853 GC11P077065 GC11P075748 GC11P075252 GC11P075203 GC11P071822


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UVRAG Gene:
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein
with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the
proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are
associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
(provided by RefSeq, Jul 2008)

GeneCards Summary for UVRAG Gene:
UVRAG (UV radiation resistance associated) is a protein-coding gene. Diseases associated with UVRAG include ascending colon cancer, and cholecystolithiasis. GO annotations related to this gene include SH3 domain binding.

Gene Wiki entry for UVRAG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UVRAG gene promoter:
         E2F-3a   E2F-4   Elk-1   E2F-5   Pax-5   E2F-2   Meis-1b   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UVRAG promoter sequence
   Search Chromatin IP Primers for UVRAG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UVRAG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5   Ensembl cytogenetic band:  11q13.5   HGNC cytogenetic band: 11q13

UVRAG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UVRAG gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P075526:  view genomic region     (about GC identifiers)

Start:
75,526,212 bp from pter      End:
75,855,282 bp from pter
Size:
329,071 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UVRAG_HUMAN, Q9P2Y5 (See protein sequence)
Recommended Name: UV radiation resistance-associated gene protein  
Size: 699 amino acids; 78151 Da
Subunit: Forms a complex with BECN1, PIK3C3 and PIK3R4. A subpopulation of these complexes also harbor
KIAA0226/Rubicon. UVRAG-containing complexes never including ATG14, both forming mutually exclusive complexes
with BECN1 through direct competition. Directly interacts with FEZ1 and SCOC. The interaction with SCOC is
reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1. Interacts with
BECN1P1/BECN2
Sequence caution: Sequence=CAA67507.1; Type=Erroneous gene model prediction;
Secondary accessions: O00392

Explore the universe of human proteins at neXtProt for UVRAG: NX_Q9P2Y5

Explore proteomics data for UVRAG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See UVRAG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003360.2  
    ENSEMBL proteins: 
     ENSP00000348455   ENSP00000436039   ENSP00000433613   ENSP00000431256   ENSP00000434082  
     ENSP00000436270   ENSP00000433414   ENSP00000438041   ENSP00000439016  

    UVRAG Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for UVRAG

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR018791 UV_resistance/autophagy_Atg14
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q9P2Y5

    ProtoNet protein and cluster: Q9P2Y5

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: UVRAG_HUMAN, Q9P2Y5
    Similarity: Contains 1 C2 domain


    Find genes that share domains with UVRAG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for UVRAG:
    UV radiation resistance-associated gene

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17891140
    GO:0017124SH3 domain binding IEA--
         
    Find genes that share ontologies with UVRAG           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UVRAG:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UVRAG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UVRAG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UVRAG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UVRAG

    miRNA
    Products:
        
    miRTarBase miRNAs that target UVRAG:
    hsa-mir-130b-3p (MIRT006270), hsa-mir-32-5p (MIRT028338), hsa-mir-192-5p (MIRT026688), hsa-mir-615-3p (MIRT040149), hsa-mir-215-5p (MIRT024353)

    Block miRNA regulation of human, mouse, rat UVRAG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UVRAG (see all 84):
    hsa-miR-582-3p hsa-miR-549 hsa-miR-642a hsa-miR-520e hsa-miR-3921 hsa-miR-519a hsa-miR-3916 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidUVRAG 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UVRAG

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    Addgene plasmids for UVRAG 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UVRAG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UVRAG_HUMAN, Q9P2Y5: Late endosome. Lysosome. Early endosome. Note=Colocalizes with RAB9-positive compartments
    involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes
    is only partial
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    vacuole5
    cytosol2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS9169138
    GO:0005764lysosome IDA19270696
    GO:0005769early endosome IDA19270696
    GO:0005770late endosome IDA19270696
    GO:0043234protein complex IEA--

    Find genes that share ontologies with UVRAG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UVRAG About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    DNA Damage0.32
    2Senescence and Autophagy
    Senescence and Autophagy


    Find genes that share SuperPaths with UVRAG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for UVRAG
        DNA Damage

    1 BioSystems Pathway for UVRAG
        Senescence and Autophagy


        Pathway & Disease-focused RT2 Profiler PCR Array including UVRAG: 
              Autophagy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UVRAG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UVRAG (Q9P2Y51, 2, 3 ENSP000003484554) via UniProtKB, MINT, STRING, and/or I2D (see all 438)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS9169138
    GO:0010508positive regulation of autophagy IEA--

    Find genes that share ontologies with UVRAG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UVRAG



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UVRAG gene: 
    NM_003369.3  

    Unigene Cluster for UVRAG:

    UV radiation resistance associated
    Hs.202470  [show with all ESTs]
    Unigene Representative Sequence: NM_003369
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356136(uc001oxc.3 uc010rrw.2 uc001oxd.3 uc010rrx.2 uc010rry.2)
    ENST00000528420 ENST00000528264 ENST00000525872 ENST00000533454(uc009yuh.1)
    ENST00000530501 ENST00000531818 ENST00000532130 ENST00000525183 ENST00000539288
    ENST00000538870
    miRNA
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    Block miRNA regulation of human, mouse, rat UVRAG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UVRAG (see all 84):
    hsa-miR-582-3p hsa-miR-549 hsa-miR-642a hsa-miR-520e hsa-miR-3921 hsa-miR-519a hsa-miR-3916 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidUVRAG 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for UVRAG 
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      QuantiTect SYBR Green Assays in human, mouse, rat UVRAG
      QuantiFast Probe-based Assays in human, mouse, rat UVRAG

    Additional mRNA sequence: 

    AB012958.1 AK095352.1 AK222772.1 AK291011.1 AK293782.1 AK296871.1 AK299978.1 AK311341.1 
    AK316133.1 BC013176.1 BC064837.1 

    10 DOTS entries:

    DT.95367764  DT.117521  DT.100653986  DT.97817841  DT.100757186  DT.95367763  DT.95367765  DT.100690903 
    DT.40306109  DT.92068572 

    Selected AceView cDNA sequences (see all 199):

    CD365123 AA380224 AW439204 BQ073155 BM990817 AI539414 BQ644762 AA768419 
    AA478118 AB012958 AA281596 BM677373 AI269963 BX447322 BX327243 AI270553 
    BU789313 AI973223 CA313950 AA237001 AI956024 NM_003369 AI914141 BC064837 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UVRAG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTATATAG
    UVRAG Expression
    About this image


    UVRAG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Mature B-Cells Peripheral Blood
    UVRAG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UVRAG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.202470

    UniProtKB/Swiss-Prot: UVRAG_HUMAN, Q9P2Y5
    Tissue specificity: Highly expressed in brain, lung, kidney and liver

        Pathway & Disease-focused RT2 Profiler PCR Array including UVRAG: 
              Autophagy in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UVRAG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UVRAG gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uvrag1 , 5 UV radiation resistance associated gene1, 5 85.69(n)1
    89.15(a)1
      7 (53.92 cM)5
    786101  NM_178635.31  NP_848750.31 
     988867435 
    chicken
    (Gallus gallus)
    Aves UVRAG1 UV radiation resistance associated gene 77.12(n)
    81.72(a)
      419091  NM_001030839.1  NP_001026010.1 
    lizard
    (Anolis carolinensis)
    Reptilia UVRAG6
    UV radiation resistance associated
    80(a)
    1 ↔ 1
    GL343298.1(1332530-1437204)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.137432 Transcribed sequences 73.15(n)    BX735008.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045959.12   -- 75.87(n)   394044  BC045959.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Uvrag6
    UV-resistance associated gene
    21(a)
    1 ↔ 1
    2L(13286790-13289561)


    ENSEMBL Gene Tree for UVRAG (if available)
    TreeFam Gene Tree for UVRAG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UVRAG (see all 6054)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1432870001,2
    C--75527938(+) TGGAG-/ATAATAAC 1 -- int10--------
    rs1814480431,2
    C--75528131(+) TACAGA/GGAGAG 1 -- int10--------
    rs734899161,2
    C,F--75528136(+) GGAGAG/TGGTAG 1 -- int12Minor allele frequency- T:0.11WA 120
    rs1857671911,2
    --75528364(+) ACTTCA/CTGGAG 1 -- int10--------
    rs1502726461,2
    --75528381(+) CTCTGA/GTAACA 1 -- int10--------
    rs118287101,2
    C,F,H--75528723(+) AGTACA/GCAGAT 1 -- int15Minor allele frequency- G:0.01NS EA NA 420
    rs352528531,2
    F--75528755(+) TTGTCC/ACCAAG 1 -- int11Minor allele frequency- A:0.50NA 4
    rs1910681331,2
    --75528837(+) TAATCC/TTAGCA 1 -- int10--------
    rs112365371,2
    C,A--75528887(+) AGTTCG/AAGACC 1 -- int12Minor allele frequency- A:0.33WA CSA 3
    rs1157589081,2
    C,F--75528973(+) GGTGGC/TGCACA 1 -- int11Minor allele frequency- T:0.08WA 118

    HapMap Linkage Disequilibrium report for UVRAG (75526212 - 75776212 bp, first 250kb of UVRAG)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for UVRAG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv27673CNV Loss19812545
    nsv394CNV Loss18451855
    nsv515484CNV Loss19592680
    nsv832212CNV Gain17160897
    nsv897924CNV Gain21882294
    nsv897925CNV Gain21882294
    nsv515973CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UVRAG
    DNA2.0 Custom Variant and Variant Library Synthesis for UVRAG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602493    OMIM disorders: --

    UniProtKB/Swiss-Prot: UVRAG_HUMAN, Q9P2Y5
  • Note=A chromosomal aberration involving UVRAG has been observed in a patient with heterotaxy (left-right
    axis malformation). Inversion Inv(11)(q13.5;q25)

  • 8 diseases for UVRAG:    
    About MalaCards
    ascending colon cancer    cholecystolithiasis    senior-loken syndrome 6    senior-loken syndrome
    xeroderma pigmentosum, group c    xeroderma pigmentosum    colon cancer    heterotaxy

    1 disease from the University of Copenhagen DISEASES database for UVRAG:
    Ascending colon cancer

    Find genes that share disorders with UVRAG           About GenesLikeMe

    Genetic Association Database (GAD): UVRAG
    Human Genome Epidemiology (HuGE) Navigator: UVRAG (3 documents)

    Export disorders for UVRAG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UVRAG gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with UVRAG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. (PubMed id 18843052)1, 2, 3 Itakura E.... Mizushima N. (Mol. Biol. Cell 2008)
    2. Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus. (PubMed id 9169138)1, 2, 3 Perelman B.... Canaani D. (Genomics 1997)
    3. Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation. (PubMed id 10798355)1, 2, 9 Iida A.... Nakamura Y. (Hum. Genet. 2000)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Association of UVRAG polymorphisms with susceptibility to non-segmental vitiligo in a Korean sample. (PubMed id 20163458)1, 4 Jeong T.J....Lee M.H. (Exp. Dermatol. 2010)
    6. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. (PubMed id 19270696)1, 2 Matsunaga K.... Yoshimori T. (Nat. Cell Biol. 2009)
    7. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. (PubMed id 16799551)1, 3 Liang C....Jung J.U. (Nat. Cell Biol. 2006)
    8. Protein kinase B/Akt1 inhibits autophagy by down-regulating UVRAG expression. (PubMed id 23200933)1 Yang W....Shin I. (Exp. Cell Res. 2013)
    9. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. (PubMed id 23954414)2 He C.... Levine B. (Cell 2013)
    10. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PubMed id 22354037)2 McKnight N.C.... Tooze S.A. (EMBO J. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7405 HGNC: 12640 AceView: UVRAG Ensembl:ENSG00000198382 euGenes: HUgn7405
    ECgene: UVRAG H-InvDB: UVRAG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UVRAG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UVRAG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UVRAG gene:
    Search GeneIP for patents involving UVRAG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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