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Aliases for UVRAG Gene

Aliases for UVRAG Gene

  • UV Radiation Resistance Associated 2 3
  • Beclin 1 Binding Protein 2 3
  • P63 3 4
  • UV Radiation Resistance-Associated Gene Protein 3
  • UV Radiation Resistance Associated Gene 2
  • Disrupted In Heterotaxy 3
  • VPS38 3
  • DHTX 3

External Ids for UVRAG Gene

Previous GeneCards Identifiers for UVRAG Gene

  • GC11P077853
  • GC11P077065
  • GC11P075748
  • GC11P075252
  • GC11P075203
  • GC11P075526
  • GC11P071822

Summaries for UVRAG Gene

Entrez Gene Summary for UVRAG Gene

  • This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for UVRAG Gene

UVRAG (UV Radiation Resistance Associated) is a Protein Coding gene. Diseases associated with UVRAG include ascending colon cancer and cholecystolithiasis. Among its related pathways are Cell Cycle / Checkpoint Control and Senescence and Autophagy. GO annotations related to this gene include SH3 domain binding.

Gene Wiki entry for UVRAG Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UVRAG Gene

Genomics for UVRAG Gene

Regulatory Elements for UVRAG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UVRAG Gene

75,815,167 bp from pter
76,144,238 bp from pter
329,072 bases
Plus strand

Genomic View for UVRAG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UVRAG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UVRAG Gene

Proteins for UVRAG Gene

  • Protein details for UVRAG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UV radiation resistance-associated gene protein
    Protein Accession:
    Secondary Accessions:
    • B3KTC1
    • O00392

    Protein attributes for UVRAG Gene

    699 amino acids
    Molecular mass:
    78151 Da
    Quaternary structure:
    • Forms a complex with BECN1, PIK3C3 and PIK3R4. A subpopulation of these complexes also harbor KIAA0226/Rubicon. UVRAG-containing complexes never including ATG14, both forming mutually exclusive complexes with BECN1 through direct competition. Directly interacts with FEZ1 and SCOC. The interaction with SCOC is reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1. Interacts with BECN2.
    • Sequence=CAA67507.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for UVRAG Gene


neXtProt entry for UVRAG Gene

Proteomics data for UVRAG Gene at MOPED

Post-translational modifications for UVRAG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UVRAG Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UVRAG (UVRAG)

No data available for DME Specific Peptides for UVRAG Gene

Domains for UVRAG Gene

Gene Families for UVRAG Gene

Protein Domains for UVRAG Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 domain.
  • Contains 1 C2 domain.
genes like me logo Genes that share domains with UVRAG: view

Function for UVRAG Gene

Molecular function for UVRAG Gene

GENATLAS Biochemistry:
UV radiation resistance-associated gene

Gene Ontology (GO) - Molecular Function for UVRAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005515 protein binding IPI 17891140
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with UVRAG: view

Phenotypes for UVRAG Gene

GenomeRNAi human phenotypes for UVRAG:
genes like me logo Genes that share phenotypes with UVRAG: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UVRAG

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for UVRAG Gene

Localization for UVRAG Gene

Subcellular locations from UniProtKB/Swiss-Prot for UVRAG Gene

Late endosome. Lysosome. Early endosome. Note=Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial.

Subcellular locations from

Jensen Localization Image for UVRAG Gene COMPARTMENTS Subcellular localization image for UVRAG gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UVRAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9169138
GO:0005764 lysosome IDA 19270696
GO:0005769 early endosome IDA 19270696
GO:0005770 late endosome IDA 19270696
GO:0005783 endoplasmic reticulum IDA 24056303
genes like me logo Genes that share ontologies with UVRAG: view

Pathways for UVRAG Gene

genes like me logo Genes that share pathways with UVRAG: view

Pathways by source for UVRAG Gene

1 Cell Signaling Technology pathway for UVRAG Gene
1 BioSystems pathway for UVRAG Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for UVRAG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS 9169138
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IMP 24056303
GO:0006914 autophagy IMP 24056303
GO:0010508 positive regulation of autophagy IEA --
GO:0032465 regulation of cytokinesis IMP 20643123
genes like me logo Genes that share ontologies with UVRAG: view

Transcripts for UVRAG Gene

Unigene Clusters for UVRAG Gene

UV radiation resistance associated:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UVRAG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UVRAG Gene

No ASD Table

Relevant External Links for UVRAG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UVRAG Gene

mRNA expression in normal human tissues for UVRAG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for UVRAG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.4), Lymph node (11.1), Gallbladder (6.2), and Blymphocyte (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UVRAG Gene

SOURCE GeneReport for Unigene cluster for UVRAG Gene Hs.202470

mRNA Expression by UniProt/SwissProt for UVRAG Gene

Tissue specificity: Highly expressed in brain, lung, kidney and liver.
genes like me logo Genes that share expressions with UVRAG: view

Expression partners for UVRAG Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UVRAG Gene

Orthologs for UVRAG Gene

This gene was present in the common ancestor of animals.

Orthologs for UVRAG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UVRAG 35
  • 91.46 (n)
  • 93.56 (a)
  • 94 (a)
(Canis familiaris)
Mammalia UVRAG 35
  • 91.6 (n)
  • 95.26 (a)
  • 95 (a)
(Mus musculus)
Mammalia Uvrag 35
  • 85.69 (n)
  • 89.15 (a)
Uvrag 16
Uvrag 36
  • 89 (a)
(Pan troglodytes)
Mammalia UVRAG 35
  • 99.48 (n)
  • 99.71 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Uvrag 35
  • 88.91 (n)
  • 94.99 (a)
(Monodelphis domestica)
Mammalia UVRAG 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia UVRAG 36
  • 61 (a)
(Gallus gallus)
Aves UVRAG 35
  • 77.12 (n)
  • 81.72 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia UVRAG 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13743 35
uvrag 35
  • 69.74 (n)
  • 74.5 (a)
(Danio rerio)
Actinopterygii -- 35
uvrag 35
  • 62.58 (n)
  • 63.56 (a)
uvrag 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta Uvrag 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
Species with no ortholog for UVRAG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UVRAG Gene

Gene Tree for UVRAG (if available)
Gene Tree for UVRAG (if available)

Paralogs for UVRAG Gene

No data available for Paralogs for UVRAG Gene

Variants for UVRAG Gene

Sequence variations from dbSNP and Humsavar for UVRAG Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs167757 -- 76,003,252(-) TCAGT(A/T)TTTTC intron-variant
rs170457 -- 76,017,481(+) acaca(A/C)aattt intron-variant
rs323632 -- 76,037,538(-) ttttg(G/T)aaaga intron-variant
rs323633 -- 76,034,156(-) GGATA(C/G)TACAA intron-variant
rs323634 -- 76,031,592(-) CATTA(C/T)ATTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UVRAG Gene

Variant ID Type Subtype PubMed ID
nsv897924 CNV Gain 21882294
nsv897925 CNV Gain 21882294
nsv832212 CNV Gain 17160897
esv27673 CNV Loss 19812545
nsv515973 CNV Gain 19592680
nsv394 CNV Loss 18451855
nsv515484 CNV Loss 19592680

Relevant External Links for UVRAG Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UVRAG Gene

Disorders for UVRAG Gene


  • Note=A chromosomal aberration involving UVRAG has been observed in a patient with heterotaxy (left-right axis malformation). Inversion Inv(11)(q13.5;q25).

(1) University of Copenhagen DISEASES for UVRAG Gene

Relevant External Links for UVRAG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with UVRAG: view

No data available for OMIM , Novoseek inferred disease relationships and Genatlas for UVRAG Gene

Publications for UVRAG Gene

  1. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. (PMID: 18843052) Itakura E. … Mizushima N. (Mol. Biol. Cell 2008) 2 3 4
  2. Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus. (PMID: 9169138) Perelman B. … Canaani D. (Genomics 1997) 2 3 4
  3. Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation. (PMID: 10798355) Iida A. … Nakamura Y. (Hum. Genet. 2000) 3 4 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. (PMID: 19050071) Sun Q. … Zhong Q. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4

Products for UVRAG Gene

  • Addgene plasmids for UVRAG

Sources for UVRAG Gene

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