Aliases for UVRAG Gene
External Ids for UVRAG Gene
Previous GeneCards Identifiers for UVRAG Gene
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for UVRAG Gene
UVRAG (UV Radiation Resistance Associated) is a Protein Coding gene. Diseases associated with UVRAG include ascending colon cancer and cholecystolithiasis. Among its related pathways are Cell Cycle / Checkpoint Control and Senescence and Autophagy. GO annotations related to this gene include SH3 domain binding.