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Aliases for UTY Gene

Aliases for UTY Gene

  • Ubiquitously Transcribed Tetratricopeptide Repeat Containing, Y-Linked 2 3
  • Ubiquitously-Transcribed Y Chromosome Tetratricopeptide Repeat Protein 3 4
  • Ubiquitously Transcribed Tetratricopeptide Repeat Gene, Y Chromosome 2 3
  • Ubiquitously Transcribed Tetratricopeptide Repeat Gene, Y-Linked 2 3
  • Ubiquitously-Transcribed TPR Protein On The Y Chromosome 3 4
  • Ubiquitously Transcribed TPR Gene On Y Chromosome 3
  • Ubiquitous TPR Motif Protein UTY 3
  • Histone Demethylase UTY 3
  • EC 1.14.11.- 4
  • EC 1.14.11 64
  • KDM6AL 3
  • KDM6C 4
  • UTY1 3

External Ids for UTY Gene

Summaries for UTY Gene

Entrez Gene Summary for UTY Gene

  • This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. The encoded protein is also a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. A large number of alternatively spliced transcripts have been observed for this gene, but the full length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2012]

GeneCards Summary for UTY Gene

UTY (Ubiquitously Transcribed Tetratricopeptide Repeat Containing, Y-Linked) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding and histone demethylase activity (H3-K36 specific). An important paralog of this gene is KDM6A.

UniProtKB/Swiss-Prot for UTY Gene

  • Male-specific histone demethylase that catalyzes trimethylated Lys-27 (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity.

Gene Wiki entry for UTY Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTY Gene

Genomics for UTY Gene

Genomic Location for UTY Gene

Start:
13,248,379 bp from pter
End:
13,480,673 bp from pter
Size:
232,295 bases
Orientation:
Minus strand

Genomic View for UTY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UTY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTY Gene

Regulatory Elements for UTY Gene

Proteins for UTY Gene

  • Protein details for UTY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14607-UTY_HUMAN
    Recommended name:
    Histone demethylase UTY
    Protein Accession:
    O14607
    Secondary Accessions:
    • A8K9Z3
    • E1U199
    • E1U1A0
    • F5H4V7
    • F8W8R7
    • O14608

    Protein attributes for UTY Gene

    Size:
    1347 amino acids
    Molecular mass:
    149548 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Cofactor:
    Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
    Quaternary structure:
    • Interacts with TLE1 and TLE2.

    Three dimensional structures from OCA and Proteopedia for UTY Gene

    Alternative splice isoforms for UTY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UTY Gene

Proteomics data for UTY Gene at MOPED

Post-translational modifications for UTY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for UTY Gene

Gene Families for UTY Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing
  • KDM :Chromatin-modifying enzymes / K-demethylases

UniProtKB/Swiss-Prot:

UTY_HUMAN
Domain:
  • Contains 1 JmjC domain.:
    • O14607
Family:
  • Belongs to the UTX family.:
    • O14607
Similarity:
  • Contains 8 TPR repeats.:
    • O14607
genes like me logo Genes that share domains with UTY: view

Function for UTY Gene

Molecular function for UTY Gene

GENATLAS Biochemistry: ubiquitously transcribed tetratricopeptide repeat (TPR) gene on chromosome Y,with several alternatively spliced isoforms,ubiquitous in a AZF deleted region
UniProtKB/Swiss-Prot Function: Male-specific histone demethylase that catalyzes trimethylated Lys-27 (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity.

Enzyme Numbers (IUBMB) for UTY Gene

Gene Ontology (GO) - Molecular Function for UTY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
GO:0051213 dioxygenase activity IEA --
GO:0071558 histone demethylase activity (H3-K27 specific) IEA --
genes like me logo Genes that share ontologies with UTY: view
genes like me logo Genes that share phenotypes with UTY: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UTY Gene

Localization for UTY Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTY Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UTY Gene COMPARTMENTS Subcellular localization image for UTY gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for UTY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with UTY: view

Pathways for UTY Gene

genes like me logo Genes that share pathways with UTY: view

Pathways by source for UTY Gene

1 KEGG pathway for UTY Gene

Gene Ontology (GO) - Biological Process for UTY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IEA --
GO:0055114 oxidation-reduction process IEA --
GO:0071557 histone H3-K27 demethylation IEA --
genes like me logo Genes that share ontologies with UTY: view

Transcripts for UTY Gene

mRNA/cDNA for UTY Gene

(55) REFSEQ mRNAs :
(347) Additional mRNA sequences :
(51) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UTY Gene

Ubiquitously transcribed tetratricopeptide repeat containing, Y-linked:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UTY Gene

No ASD Table

Relevant External Links for UTY Gene

GeneLoc Exon Structure for
UTY
ECgene alternative splicing isoforms for
UTY

Expression for UTY Gene

mRNA expression in normal human tissues for UTY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UTY Gene

SOURCE GeneReport for Unigene cluster for UTY Gene Hs.115277

genes like me logo Genes that share expressions with UTY: view

Orthologs for UTY Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UTY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTY 37
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UTY 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uty 16
Uty 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 80 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 77 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 73 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii kdm6a 37
  • 67 (a)
ManyToMany
kdm6al 37
  • 63 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Utx 37
  • 43 (a)
OneToMany
CG5640 38
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea utx-1 37
  • 30 (a)
OneToMany
F18E9.5b 38
  • 31 (a)
F23D12.5 38
  • 28 (a)
C29F7.6 38
  • 27 (a)
D2021.1 38
  • 38 (a)
F18E9.5a 38
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CYC8 37
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8580 37
  • 42 (a)
OneToMany
Species with no ortholog for UTY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UTY Gene

ENSEMBL:
Gene Tree for UTY (if available)
TreeFam:
Gene Tree for UTY (if available)

Paralogs for UTY Gene

Paralogs for UTY Gene

Selected SIMAP similar genes for UTY Gene using alignment to 260 proteins:

genes like me logo Genes that share paralogs with UTY: view

Variants for UTY Gene

Sequence variations from dbSNP and Humsavar for UTY Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs15434 -- 13,287,334(+) CAGAA(G/T)CAGAG intron-variant
rs15435 -- 13,287,364(+) CTCTA(G/T)CAGAG intron-variant
rs2032653 -- 13,479,657(+) GCGCA(C/G)GATTT reference, synonymous-codon, nc-transcript-variant
rs2032654 -- 13,355,944(+) AACTG(A/G)CTTTC synonymous-codon, reference, nc-transcript-variant
rs2032655 -- 13,479,321(+) GGCTG(G/T)AGAGA intron-variant

Relevant External Links for UTY Gene

HapMap Linkage Disequilibrium report
UTY

No data available for Structural Variations from Database of Genomic Variants (DGV) for UTY Gene

Disorders for UTY Gene

(2) University of Copenhagen DISEASES for UTY Gene

(2) Novoseek inferred disease relationships for UTY Gene

Disease -log(P) Hits PubMed IDs
shock 2.44 2
immunodeficiency 0 2

Relevant External Links for UTY

Genetic Association Database (GAD)
UTY
Human Genome Epidemiology (HuGE) Navigator
UTY
genes like me logo Genes that share disorders with UTY: view

No data available for UniProtKB/Swiss-Prot for UTY Gene

Publications for UTY Gene

  1. The UTX gene escapes X inactivation in mice and humans. (PMID: 9499428) Greenfield A. … Koopman P. (Hum. Mol. Genet. 1998) 2 3 23
  2. An H-YDb epitope is encoded by a novel mouse Y chromosome gene. (PMID: 8944031) Greenfield A. … Koopman P. (Nat. Genet. 1996) 2 3
  3. Functional coherence of the human Y chromosome. (PMID: 9381176) Lahn B.T. … Page D.C. (Science 1997) 3 4
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  5. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 3 4

Products for UTY Gene

  • Addgene plasmids for UTY

Sources for UTY Gene

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