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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UTY Gene

protein-coding GIFtS: 54
GCID: GC0YM015360

ubiquitously transcribed tetratricopeptide repeat containing,...

(Previous names: ubiquitously transcribed tetratricopeptide repeat gene,...)

Explore 8 diseases affiliated with
UTY via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ubiquitously Transcribed Tetratricopeptide Repeat Containing, Y-Linked¹ ²		Histone Demethylase UTY²
Ubiquitously Transcribed Tetratricopeptide Repeat Gene, Y Chromosome¹ ²		Ubiquitous TPR Motif Protein UTY²
Ubiquitously Transcribed Tetratricopeptide Repeat Gene, Y-Linked¹ ²		Ubiquitously Transcribed TPR Gene On Y Chromosome²
Ubiquitously-Transcribed TPR Protein On The Y Chromosome² ³		EC 1.14.11.-³
Ubiquitously-Transcribed Y Chromosome Tetratricopeptide Repeat Protein² ³		EC 1.14.11⁸
UTY1²

External Ids:	HGNC: 12638¹	Entrez Gene: 7404²	Ensembl: ENSG00000183878⁷	OMIM: 400009⁵	UniProtKB: O14607³

Export aliases for UTY gene to outside databases

Previous GC identifers: GC0YM014678 GC0YM014368 GC0YM013798 GC0YM010010

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UTY:

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein

interactions. The encoded protein is also a minor histocompatibility antigen which may induce graft rejection of male

stem cell grafts. A large number of alternatively spliced transcripts have been observed for this gene, but the full

length nature of some of these variants has not been determined. (provided by RefSeq, Apr 2012)

UniProtKB/Swiss-Prot: UTY_HUMAN, O14607

Function: Histone demethylase (By similarity)

Gene Wiki entry for UTY

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000024.9 NT_011875.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UTY gene promoter:
ER-alpha NF-YA NF-YB FOXC1 CBF-A CBF-B CP1A NF-Y En-1 CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UTY promoter sequence

Search SABiosciences Chromatin IP Primers for UTY

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UTY

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yq11 Ensembl cytogenetic band: Yq11.221 HGNC cytogenetic band: Yq11.221

UTY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UTY gene location

GeneLoc information about chromosome Y GeneLoc Exon Structure

GeneLoc location for GC0YM015360: view genomic region (about GC identifiers)

Start:	15,360,259 bp from pter	End:	15,592,553 bp from pter
Size:	232,295 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UTY_HUMAN, O14607 (See protein sequence)

Recommended Name: Histone demethylase UTY

Size: 1347 amino acids; 149548 Da

Cofactor: Ascorbate (By similarity)

Cofactor: Fe(2+) (By similarity)

Subunit: Interacts with TLE1 and TLE2 (By similarity)

Subcellular location: Nucleus (Potential)

Secondary accessions: A8K9Z3 E1U199 E1U1A0 F5H4V7 F8W8R7 O14608

Alternative splicing: 5 isoforms: O14607-1 O14607-2 O14607-3 O14607-4 O14607-5

Explore the universe of human proteins at neXtProt for UTY: NX_O14607

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14607

4/16 DME Specific Peptides for UTY (O14607) (see all 16)

UTY Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (25 alternative transcripts):

NP_001245178.1 NP_001245179.1 NP_001245180.1 NP_001245181.1 NP_001245182.1 NP_001245183.1 NP_001245184.1 NP_001245185.1

NP_001245186.1 NP_001245187.1 NP_001245188.1 NP_001245189.1 NP_001245190.1 NP_001245191.1 NP_001245192.1 NP_001245193.1

NP_001245194.1 NP_001245195.1 NP_001245196.1 NP_001245197.1 NP_001245198.1 NP_001245199.1 NP_009056.3 NP_872600.1

ENSEMBL proteins:

ENSP00000328939 ENSP00000355420 ENSP00000330446 ENSP00000372349 ENSP00000372352

ENSP00000439922 ENSP00000445274 ENSP00000441943 ENSP00000442047

Human Recombinant Protein Products:

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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for UTY
	GenScript Custom Purified and Recombinant Proteins Services for UTY
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for UTY

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

UTY for ontologies About GeneDecksing

UTY Antibody Products:

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	GenScript Superior Antibodies for UTY
	Novus Biologicals UTY Antibodies
	Search for Antibodies for UTY at Abcam
	Uscn Antibodies for UTY
	ThermoFisher Antibodies for UTY

Assay Products for UTY:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for UTY
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for UTY

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UTY for domains About GeneDecksing

5 InterPro domains/families:

IPR003347 JmjC_dom

IPR001440 TPR-1

IPR011990 TPR-like_helical

IPR013026 TPR-contain_dom

IPR019734 TPR_repeat

Graphical View of Domain Structure for InterPro Entry O14607

ProtoNet protein and cluster: O14607

1 Blocks protein family: IPB003347 Transcription factor jumonji

UniProtKB/Swiss-Prot: UTY_HUMAN, O14607

Similarity: Belongs to the UTX family

Similarity: Contains 1 JmjC domain

Similarity: Contains 8 TPR repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: UTY_HUMAN, O14607

Function: Histone demethylase (By similarity)

Genatlas biochemistry entry for UTY:

ubiquitously transcribed tetratricopeptide repeat (TPR) gene on chromosome Y,with several alternatively spliced

isoforms,ubiquitous in a AZF deleted region

Enzyme Numbers (IUBMB): EC 1.14.11.-¹ EC 1.14.11²

miRNA Products:		OriGene 3'-UTR Clone (see all 3): UTY Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UTY
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate UTY (see all 34):
		hsa-miR-576-3p hsa-miR-4328 hsa-miR-371-5p hsa-miR-298 hsa-miR-3148 hsa-miR-4280 hsa-miR-3163 hsa-miR-455-5p

		SwitchGear 3'UTR luciferase reporter plasmid: UTY 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UTY (see all 4) OriGene shRNA RFP: UTY OriGene siRNA: UTY
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UTY

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for UTY

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UTY (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UTY (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): UTY (NM_001128425)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTY

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for UTY
		Search LifeMap BioReagents cell lines for UTY

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTY

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	--
GO:0046872	metal ion binding	IEA	--
GO:0051864	histone demethylase activity (H3-K36 specific)	IEA	--

UTY for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for UTY

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for UTY (O14607³ ENSP00000328939⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCOA6	Q14686³, ENSP00000351894⁴	I2D: score=1 STRING: ENSP00000351894
TLE1	Q04724³, ENSP00000365682⁴	I2D: score=3 STRING: ENSP00000365682
TLE2	Q04725³, ENSP00000262953⁴	I2D: score=3 STRING: ENSP00000262953
PRDX2	ENSP00000301522⁴	STRING: ENSP00000301522

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001701	in utero embryonic development	IEA	--
GO:0007507	heart development	IEA	--
GO:0016568	chromatin modification	--	--
GO:0031935	regulation of chromatin silencing	IEA	--
GO:0045184	establishment of protein localization	IEA	--

UTY for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UTY
Search CenterWatch for drugs/clinical trials and news about UTY

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UTY gene (25 alternative transcripts):

NM_001258249.1 NM_001258250.1 NM_001258251.1 NM_001258252.1 NM_001258253.1 NM_001258254.1 NM_001258255.1 NM_001258256.1

NM_001258257.1 NM_001258258.1 NM_001258259.1 NM_001258260.1 NM_001258261.1 NM_001258262.1 NM_001258263.1 NM_001258264.1

NM_001258265.1 NM_001258266.1 NM_001258267.1 NM_001258268.1 NM_001258269.1 NM_001258270.1 NM_007125.4 NM_182659.1

Unigene Cluster for UTY:

Ubiquitously transcribed tetratricopeptide repeat containing, Y-linked

Hs.115277 [show with all ESTs]

Unigene Representative Sequence: NR_047607

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000331397(uc022cjj.1 uc022cjk.1 uc004fsx.1 uc022cjl.1 uc022cjm.1 uc022cjn.1 uc022cjo.1 uc022cjp.1 uc022cjq.1 uc022cjr.1 uc022cjs.1 uc022cjt.1 uc022cju.1 uc022cjv.1 uc022cjw.1 uc022cjx.1 uc022cjy.1 uc022cjz.1 uc022cka.1 uc022ckb.1 uc022ckc.1 uc022ckd.1 uc022cke.1 uc022ckf.1 uc022ckg.1 uc022ckh.1 uc022cki.1 uc022ckj.1 uc022ckk.1 uc022ckl.1 uc022ckm.1 uc022ckn.1 uc022cko.1 uc022ckp.1 uc022ckq.1 uc022ckr.1 uc022cks.1 uc022ckt.1 uc022cku.1 uc022ckv.1 uc022ckw.1 uc022ckx.1 uc022cky.1 uc022ckz.1 uc022cla.1 uc022clb.1)

ENST00000362096(uc022clc.1 uc022cld.1 uc022cle.1 uc022clf.1 uc022clg.1 uc022clh.1 uc022cli.1 uc022clj.1 uc022clk.1 uc022cll.1 uc022clm.1 uc022cln.1 uc022clo.1 uc022clp.1 uc022clq.1 uc004fsy.3 uc022clr.1 uc022cls.1 uc022clt.1 uc022clu.1 uc022clv.1 uc022clw.1 uc022clx.1 uc022cly.1 uc022clz.1)

ENST00000329134(uc022cma.1 uc022cmb.1 uc022cmc.1 uc022cmd.1 uc022cme.1 uc022cmf.1 uc022cmg.1 uc022cmh.1 uc022cmi.1 uc022cmj.1 uc022cmk.1 uc022cml.1 uc022cmm.1 uc022cmn.1 uc022cmo.1 uc022cmp.1 uc022cmq.1 uc022cmr.1 uc022cms.1 uc022cmt.1 uc022cmu.1 uc022cmv.1 uc022cmw.1 uc022cmx.1 uc022cmy.1 uc022cmz.1 uc022cna.1 uc022cnb.1 uc022cnc.1 uc022cnd.1 uc022cne.1 uc022cnf.1 uc022cng.1 uc022cnh.1 uc004fsz.3 uc022cni.1 uc022cnj.1 uc022cnk.1 uc022cnl.1 uc022cnm.1 uc022cnn.1 uc022cno.1 uc022cnp.1 uc022cnq.1 uc022cnr.1 uc022cns.1 uc022cnt.1 uc022cnu.1 uc022cnv.1 uc022cnw.1 uc022cnx.1 uc022cny.1 uc022cnz.1 uc022coa.1 uc022cob.1 uc022coc.1 uc022cod.1)

ENST00000382893 ENST00000479713 ENST00000478900 ENST00000474365 ENST00000382896(uc004fsw.1)

ENST00000537580 ENST00000538878 ENST00000540140 ENST00000545955

miRNA Products:		OriGene 3'-UTR Clone (see all 3): UTY Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UTY
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate UTY (see all 34):
		hsa-miR-576-3p hsa-miR-4328 hsa-miR-371-5p hsa-miR-298 hsa-miR-3148 hsa-miR-4280 hsa-miR-3163 hsa-miR-455-5p

		SwitchGear 3'UTR luciferase reporter plasmid: UTY 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UTY (see all 4) OriGene shRNA RFP: UTY OriGene siRNA: UTY
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UTY

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UTY (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UTY (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): UTY (NM_001128425)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for UTY
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTY

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		SABiosciences RT² qPCR Primer Assay in human, mouse / rat UTY
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UTY
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UTY

Additional cDNA sequence:

AF000994.1 AF000995.1 AF000996.1 AK292858.1 AK308952.1 AY682463.1 AY730613.1 AY769061.1

AY769062.1 AY769063.1 AY769064.1 AY769065.1 AY769066.1 AY769067.1 AY769068.1 AY769069.1

AY934848.1 AY934849.1 AY934850.1 AY934851.1 AY934852.1 AY934853.1 AY934854.1 AY934855.1

AY934856.1 AY934857.1 BC012581.1 BC029389.1 BC051718.1 BC071744.1 CR936684.1 DQ012094.1

DQ140388.1 DQ140389.1 DQ140390.1 DQ341385.1 DQ341386.1 DQ341387.1 DQ345542.1 DQ345543.1

DQ345544.1 DQ350456.1 DQ350457.1 DQ350458.1 DQ350459.1 EF491796.1 EF612660.1 EF612661.1

EF612662.1 EF612663.1 EF612664.1 EF612665.1 EF612666.1 EF612667.1 EF612668.1 EF612669.1

EF612670.1 EF612671.1 EF612672.1 EF612673.1 EF612674.1 EF612675.1 EF612676.1 EF612677.1

EF612678.1 EF612679.1 EF612680.1 EF612681.1 EF612682.1 EF612683.1 EF612684.1 EF612685.1

EF612686.1 EF612687.1 EF612688.1 EF612689.1 EF612690.1 EF612691.1 EF612692.1 EF612693.1

EF612694.1 EF612695.1 EF612696.1 EF612697.1 EF612698.1 EF612699.1 EF653165.1 EF653166.1

EF653167.1 EF653168.1 EF653169.1 EF653170.1 EF653171.1 EF653172.1 EF653173.1 EF653174.1

EF653175.1 EF653176.1 EF653177.1 EF653178.1 EF653179.1 EF653180.1 EF653181.1 EF653182.1

EF653183.1 EF653184.1 EF653185.1 EF653186.1 EF653187.1 EF653188.1 EF653189.1 EF653190.1

EF653191.1 EF653192.1 EF653193.1 EF653194.1 EF653195.1 EF653196.1 EF653197.1 EF653198.1

EF653199.1 EF653200.1 EF653201.1 EF653202.1 EF653203.1 EF653204.1 EF653205.1 EF653206.1

EF653207.1 EF653208.1 EF653209.1 EF653210.1 EF653211.1 EF653212.1 EF653213.1 EF653214.1

EF653215.1 EF653216.1 EF653217.1 EF653218.1 EF653219.1 EF653220.1 EF653221.1 EF653222.1

EF653223.1 EF653224.1 EF685283.1 EF685284.1 EF685285.1 EF685286.1 EF685287.1 EF685288.1

EF685289.1 EF685290.1 EF685291.1 EF685292.1 EF685293.1 EF685294.1 EF685295.1 EF685296.1

EF685297.1 EF685298.1 EF685299.1 EF685300.1 EF685301.1 EF685302.1 EF685303.1 EF685304.1

EF685305.1 EF685306.1 EF685307.1 EF685308.1 EF685309.1 EF685310.1 EF685311.1 EF685312.1

EF685313.1 EF685314.1 EF685315.1 EF685316.1 EF685317.1 EF685318.1 EF685319.1 EF685320.1

EF685321.1 EF685322.1 EF685323.1 EF685324.1 EF685325.1 EF685326.1 EF685327.1 EF685328.1

EF685329.1 EF685330.1 EF685331.1 EF685332.1 EF685333.1 EF685334.1 EF685335.1 EF685336.1

EF685337.1 EF685338.1 EF685339.1 EF685340.1 EF685341.1 EF685342.1 EU026275.1 EU026276.1

EU026277.1 EU026278.1 EU026279.1 EU026280.1 EU026281.1 EU026282.1 EU026284.1 EU026285.1

EU026286.1 EU026287.1 EU026288.1 EU026289.1 EU026290.1 EU026292.1 EU026293.1 EU026294.1

EU026295.1 EU026296.1 EU026297.1 EU026298.1 EU026299.1 EU026300.1 EU026301.1 EU026302.1

EU026303.1 EU026304.1 EU026305.1 EU026306.1 EU026307.1 EU026308.1 EU026309.1 EU026310.1

EU026311.1 EU026312.1 EU026313.1 EU026314.1 EU026315.1 EU026316.1 EU026317.1 EU026318.1

EU026319.1 EU026320.1 EU026321.1 EU026322.1 EU026323.1 EU026324.1 EU026325.1 EU026326.1

EU026327.1 EU026328.1 EU026329.1 EU026330.1 EU026331.1 EU026332.1 EU026333.1 EU026334.1

EU026335.1 EU026336.1 EU026337.1 EU026338.1 EU026339.1 EU026340.1 EU026341.1 EU026342.1

EU026343.1 EU026344.1 EU026345.1 EU026346.1 EU026347.1 EU026348.1 EU026349.1 EU026350.1

EU026351.1 EU116343.1 EU116344.1 EU116345.1 EU116346.1 EU116347.1 EU116348.1 EU116349.1

EU116350.1 EU116351.1 EU116352.1 EU116353.1 EU163941.1 EU163942.1 EU163943.1 NR_047596.1

NR_047597.1 NR_047598.1 NR_047599.1 NR_047600.1 NR_047601.1 NR_047602.1 NR_047603.1 NR_047604.1

NR_047605.1 NR_047606.1 NR_047607.1 NR_047608.1 NR_047609.1 NR_047610.1 NR_047611.1 NR_047612.1

NR_047613.1 NR_047614.1 NR_047615.1 NR_047616.1 NR_047617.1 NR_047618.1 NR_047619.1 NR_047620.1

NR_047621.1 NR_047622.1 NR_047623.1 NR_047624.1 NR_047625.1 NR_047626.1 NR_047627.1 NR_047628.1

NR_047629.1 NR_047630.1 NR_047631.1 NR_047632.1 NR_047633.1 NR_047634.1 NR_047635.1 NR_047636.1

NR_047637.1 NR_047638.1 NR_047639.1 NR_047640.1 NR_047641.1 NR_047642.1 NR_047643.1 NR_047644.1

NR_047645.1 NR_047646.1 NR_047647.1

9 DOTS entries:

DT.75104507 DT.100780965 DT.100780961 DT.101976877 DT.100780964 DT.100780959 DT.100726189 DT.91702098

24/51 AceView cDNA sequences (see all 51):

CD251200 BP354432 BM955951 AF000995 CA413286 NM_182660 AA831724 NM_007125

BX090888 BX509796 AF000996 NM_182659 AF000994 CR595226 BX444614 AI346210

AI004861 BC029389 AW295471 AL703945 BX506603 BP354464 BM172452 BC071744

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UTY expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTGGGGTG

About this image

UTY expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cells

Reproductive System

Testis Somatic Cells

Positive expression

Microarrays (high-throughput)

Testis

Expression:

Positive

Negative

cell-identifying gene

Selective marker

Experimental details:

Curated

High-throughput

Microarrays

In-situ hybridization

See UTY Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UTY

SOURCE GeneReport for Unigene cluster: Hs.115277

SABiosciences Custom PCR Arrays for UTY

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for UTY gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KDM6A⁶	Uncharacterized protein	79(a)	1 → many	1(114402920-114550911)
lizard (Anolis carolinensis)	Reptilia	--	--	75(a)	1 → many	3(135665327-135777229)
zebrafish (Danio rerio)	Actinopterygii	kdm6a⁶ kdm6al⁶	lysine (K)-specific demethylase 6A, like	67(a) 63(a)	many ↔ many many ↔ many	9(34746176-34820186) 6(59580423-59621279)
fruit fly (Drosophila melanogaster)	Insecta	CG5640³	transcriptional repressor	57(a)		31C3 --
worm (Caenorhabditis elegans)	Secernentea	D2021.1³	glucose repression mediator protein	38(a) (best of 5)		X(8592454-8598117) --

ENSEMBL Gene Tree for UTY (if available)
TreeFam Gene Tree for UTY (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for UTY gene

KDM6B² KDM6A²

18/160 SIMAP similar genes for UTY using alignment to 260 protein entries: UTY_HUMAN (see all proteins) (see all similar genes):

TGM4 pp12301 FAM3A RTBDN DKFZp686A03225 C10orf137

FLJ00047 SUN3 X-linked retinopathy protein C12orf76 DNMT1 NCKAP1L

DCTN5 EML2 MEFV ATL2 C11orf80 CFLAR

UTY for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr Y pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9786378^1,2	C	--	15360167(+)	`AAATAC/GCTTCT`	75	--	ds500¹		1		WA	2
rs72487503^1,2	C	--	15364625(-)	`AAGGCG/ACAGAT`	75	--	int¹		1		NA	2
rs79800808^1,2	C	--	15366099(+)	`AATCTA/GCATAA`	75	--	int¹		0	--	--	--	--
rs35828523^1,2	C	--	15372130(+)	`ACAAAA/CCAACT`	75	--	int¹		1		NA	2
rs9785890^1,2	C,F	--	15375740(+)	`ATGCCG/ATGGTG`	75	--	int¹		2		NA WA	4
rs113774637^1,2	C	--	15376300(-)	`GAGGAT/AGTGGA`	75	--	int¹		2		CSA	2
rs9786211^1,2	C,F	--	15377120(+)	`GTTCCG/ATATAA`	75	--	int¹		3		NA WA	6
rs78228687^1,2	C,F	--	15378257(+)	`GTGTCC/TGTTTG`	75	--	int¹		1		NA	4
rs74355642^1,2	F	--	15378349(-)	`CAAAAT/AATCAA`	75	--	int¹		2		NA	4
rs75720512^1,2	C	--	15384246(+)	`CTTTTG/TCAGAA`	75	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for UTY (15360259 - 15592553 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UTY: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UTY

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

UTY for disorders           About GeneDecksing

OMIM gene information: 400009    OMIM disorders: --

8 diseases for UTY:    About MalaCards

sertoli cell-only syndrome x inactivation male infertility infertility

azoospermia retinoblastoma immunodeficiency melanoma

2 diseases from the University of Copenhagen DISEASES database for UTY:

Azoospermia Sertoli cell-only syndrome

2 Novoseek disease relationships for UTY gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	2.44	2	10751404 (1), 7585962 (1)
immunodeficiency	0	2	9573291 (1), 9766974 (1)

Human Genome Epidemiology (HuGE) Navigator: UTY (1 document)

Export disorders for UTY gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for UTY gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with UTY)

Utopia: connect your pdf to the dynamic
world of online information

The UTX gene escapes X inactivation in mice and humans. (PubMed id 9499428)^{1, 3, 9} Greenfield A....Koopman P. (1998)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)^{1, 2} Skaletsky H.... Page D.C. (2003)
Functional coherence of the human Y chromosome. (PubMed id 9381176)^{1, 2} Lahn B.T. and Page D.C. (1997)
An H-YDb epitope is encoded by a novel mouse Y chromosome gene. (PubMed id 8944031)^{1, 3} Greenfield A....Koopman P. (1996)
Huge splicing frequency in human Y chromosomal UTY gen e. (PubMed id 21329462)¹ Laaser I....Adamski J. (2011)
Genetic variants of y chromosome are associated with a protective lipid profile in black men. (PubMed id 18511697)¹ Russo P....Cappuccio F.P. (2008)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Targeted inactivation of MLL3 histone H3-Lys-4 methyl transferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. (PubMed id 19047629)¹ Lee J....Lee J.W. (2008)
Non-EST-based prediction of novel alternatively splic ed cassette exons with cell signaling function in Caenorhabditis elegans and hu man. (PubMed id 17452356)¹ Leparc G.G. and Mitra R.D. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

			AND	OR
	Aliases
	Disorders
	Free Text

	Query String		PubMed OMIM NCBI Bookshelf
		(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7404	HGNC: 12638	AceView: UTY	Ensembl:ENSG00000183878	euGenes: HUgn7404
ECgene: UTY	H-InvDB: UTY

(According to HUGE)
About This Section

--

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for UTY	Pharmacogenomics, SNPs, Pathways

Intellectual Property for UTY gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for UTY gene:
Search GeneIP for patents involving UTY

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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