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Aliases for UTY Gene

Aliases for UTY Gene

  • Ubiquitously Transcribed Tetratricopeptide Repeat Containing, Y-Linked 2 3 5
  • Ubiquitously-Transcribed Y Chromosome Tetratricopeptide Repeat Protein 3 4
  • Ubiquitously Transcribed Tetratricopeptide Repeat Gene, Y Chromosome 2 3
  • Ubiquitously Transcribed Tetratricopeptide Repeat Gene, Y-Linked 2 3
  • Ubiquitously-Transcribed TPR Protein On The Y Chromosome 3 4
  • Ubiquitously Transcribed TPR Gene On Y Chromosome 3
  • Ubiquitous TPR Motif Protein UTY 3
  • EC 1.14.11.- 4
  • EC 1.14.11 63
  • KDM6AL 3
  • KDM6C 4
  • UTY1 3

External Ids for UTY Gene

Previous GeneCards Identifiers for UTY Gene

  • GC0YM014678
  • GC0YM014368
  • GC0YM013798
  • GC0YM015360
  • GC0YM010010

Summaries for UTY Gene

Entrez Gene Summary for UTY Gene

  • This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. The encoded protein is also a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. A large number of alternatively spliced transcripts have been observed for this gene, but the full length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2012]

GeneCards Summary for UTY Gene

UTY (Ubiquitously Transcribed Tetratricopeptide Repeat Containing, Y-Linked) is a Protein Coding gene. Among its related pathways are Chromatin organization and Transcriptional misregulation in cancer. GO annotations related to this gene include dioxygenase activity and histone demethylase activity (H3-K27 specific). An important paralog of this gene is KDM6A.

UniProtKB/Swiss-Prot for UTY Gene

  • Male-specific histone demethylase that catalyzes trimethylated Lys-27 (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity.

Gene Wiki entry for UTY Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTY Gene

Genomics for UTY Gene

Regulatory Elements for UTY Gene

Enhancers for UTY Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UTY on UCSC Golden Path with GeneCards custom track

Genomic Location for UTY Gene

13,233,920 bp from pter
13,480,673 bp from pter
246,754 bases
Minus strand

Genomic View for UTY Gene

Genes around UTY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTY Gene

Proteins for UTY Gene

  • Protein details for UTY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histone demethylase UTY
    Protein Accession:
    Secondary Accessions:
    • A8K9Z3
    • E1U199
    • E1U1A0
    • F5H4V7
    • F8W8R7
    • O14608

    Protein attributes for UTY Gene

    1347 amino acids
    Molecular mass:
    149548 Da
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
    Quaternary structure:
    • Interacts with TLE1 and TLE2.

    Three dimensional structures from OCA and Proteopedia for UTY Gene

    Alternative splice isoforms for UTY Gene


neXtProt entry for UTY Gene

Proteomics data for UTY Gene at MOPED

Post-translational modifications for UTY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for UTY Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 JmjC domain.
  • Belongs to the UTX family.
  • Contains 8 TPR repeats.
  • Contains 1 JmjC domain.
  • Belongs to the UTX family.
  • Contains 8 TPR repeats.
genes like me logo Genes that share domains with UTY: view

Function for UTY Gene

Molecular function for UTY Gene

GENATLAS Biochemistry:
ubiquitously transcribed tetratricopeptide repeat (TPR) gene on chromosome Y,with several alternatively spliced isoforms,ubiquitous in a AZF deleted region
UniProtKB/Swiss-Prot Function:
Male-specific histone demethylase that catalyzes trimethylated Lys-27 (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity.

Enzyme Numbers (IUBMB) for UTY Gene

Gene Ontology (GO) - Molecular Function for UTY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051213 dioxygenase activity IEA --
GO:0071558 histone demethylase activity (H3-K27 specific) IEA --
genes like me logo Genes that share ontologies with UTY: view
genes like me logo Genes that share phenotypes with UTY: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UTY Gene

Localization for UTY Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTY Gene


Subcellular locations from

Jensen Localization Image for UTY Gene COMPARTMENTS Subcellular localization image for UTY gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for UTY Gene

Pathways & Interactions for UTY Gene

genes like me logo Genes that share pathways with UTY: view

Pathways by source for UTY Gene

Gene Ontology (GO) - Biological Process for UTY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IEA --
genes like me logo Genes that share ontologies with UTY: view

No data available for SIGNOR curated interactions for UTY Gene

Drugs & Compounds for UTY Gene

No Compound Related Data Available

Transcripts for UTY Gene

Unigene Clusters for UTY Gene

Ubiquitously transcribed tetratricopeptide repeat containing, Y-linked:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTY Gene

No ASD Table

Relevant External Links for UTY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UTY Gene

mRNA expression in normal human tissues for UTY Gene

Protein differential expression in normal tissues from HIPED for UTY Gene

This gene is overexpressed in Pancreatic juice (41.7) and Heart (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UTY Gene

SOURCE GeneReport for Unigene cluster for UTY Gene Hs.115277

genes like me logo Genes that share expression patterns with UTY: view

Protein tissue co-expression partners for UTY Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UTY Gene

Orthologs for UTY Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UTY Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UTY 36
  • 75 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
(Mus musculus)
Mammalia Uty 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
(Pan troglodytes)
Mammalia UTY 36
  • 92 (a)
(Gallus gallus)
Aves -- 36
  • 77 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 73 (a)
(Danio rerio)
Actinopterygii kdm6a 36
  • 67 (a)
kdm6al 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5640 37
  • 57 (a)
Utx 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea C29F7.6 37
  • 27 (a)
D2021.1 37
  • 38 (a)
F18E9.5a 37
  • 31 (a)
F18E9.5b 37
  • 31 (a)
F23D12.5 37
  • 28 (a)
utx-1 36
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CYC8 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8580 36
  • 42 (a)
Species with no ortholog for UTY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UTY Gene

Gene Tree for UTY (if available)
Gene Tree for UTY (if available)

Paralogs for UTY Gene

Paralogs for UTY Gene

(173) SIMAP similar genes for UTY Gene using alignment to 260 proteins:

genes like me logo Genes that share paralogs with UTY: view

Variants for UTY Gene

Sequence variations from dbSNP and Humsavar for UTY Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs15434 -- 13,287,334(+) CAGAA(G/T)CAGAG intron-variant
rs15435 -- 13,287,364(+) CTCTA(G/T)CAGAG intron-variant
rs1133865 -- 13,235,822(-) agcct(A/G)ggcaa intron-variant
rs2032653 -- 13,479,657(+) GCGCA(C/G)GATTT nc-transcript-variant, reference, synonymous-codon
rs2032654 -- 13,355,944(+) AACTG(A/G)CTTTC nc-transcript-variant, reference, synonymous-codon

Variation tolerance for UTY Gene

Gene Damage Index Score: 0.33; 7.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for UTY Gene

Disorders for UTY Gene

Relevant External Links for UTY

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UTY Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTY Gene

Publications for UTY Gene

  1. The UTX gene escapes X inactivation in mice and humans. (PMID: 9499428) Greenfield A. … Koopman P. (Hum. Mol. Genet. 1998) 2 3 23 67
  2. An H-YDb epitope is encoded by a novel mouse Y chromosome gene. (PMID: 8944031) Greenfield A. … Koopman P. (Nat. Genet. 1996) 2 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Human UTY(KDM6C) is a male-specific N-methyl lysyl demethylase. (PMID: 24798337) Walport L.J. … Johansson C. (J. Biol. Chem. 2014) 3
  5. Huge splicing frequency in human Y chromosomal UTY gene. (PMID: 21329462) Laaser I. … Adamski J. (OMICS 2011) 3

Products for UTY Gene

Sources for UTY Gene