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UTY Gene

protein-coding   GIFtS: 56
GCID: GC0YM015360

Ubiquitously Transcribed Tetratricopeptide Repeat Containing,...

(Previous names: ubiquitously transcribed tetratricopeptide repeat gene,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ubiquitously Transcribed Tetratricopeptide Repeat Containing,
Y-Linked1 2
     UTY12
Ubiquitously Transcribed Tetratricopeptide Repeat Gene, Y Chromosome1 2     Histone Demethylase UTY2
Ubiquitously Transcribed Tetratricopeptide Repeat Gene, Y-Linked1 2     Ubiquitous TPR Motif Protein UTY2
Ubiquitously-Transcribed TPR Protein On The Y Chromosome2 3     Ubiquitously Transcribed TPR Gene On Y Chromosome2
Ubiquitously-Transcribed Y Chromosome Tetratricopeptide Repeat Protein2 3     EC 1.14.11.-3
KDM6AL2     EC 1.14.118

External Ids:    HGNC: 126381   Entrez Gene: 74042   Ensembl: ENSG000001838787   OMIM: 4000095   UniProtKB: O146073   
ORGUL members:         

Export aliases for UTY gene to outside databases

Previous GC identifers: GC0YM014678 GC0YM014368 GC0YM013798 GC0YM010010


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UTY Gene:
This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in
protein-protein interactions. The encoded protein is also a minor histocompatibility antigen which may induce
graft rejection of male stem cell grafts. A large number of alternatively spliced transcripts have been observed
for this gene, but the full length nature of some of these variants has not been determined. (provided by RefSeq,
Apr 2012)

GeneCards Summary for UTY Gene:
UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked) is a protein-coding gene. Diseases associated with UTY include sertoli cell-only syndrome, and male infertility. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding and histone demethylase activity (H3-K36 specific). An important paralog of this gene is KDM6B.

UniProtKB/Swiss-Prot: UTY_HUMAN, O14607
Function: Histone demethylase (By similarity)

Gene Wiki entry for UTY Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000024.10  NT_011875.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the UTY gene promoter:
         ER-alpha   NF-YA   NF-YB   FOXC1   CBF-A   CBF-B   CP1A   NF-Y   En-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUTY promoter sequence
   Search Chromatin IP Primers for UTY

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UTY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yq11   Ensembl cytogenetic band:  Yq11.221   HGNC cytogenetic band: Yq11.221

UTY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UTY gene location

GeneLoc information about chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YM015360:  view genomic region     (about GC identifiers)

Start:
15,360,259 bp from pter      End:
15,592,553 bp from pter
Size:
232,295 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UTY_HUMAN, O14607 (See protein sequence)
Recommended Name: Histone demethylase UTY  
Size: 1347 amino acids; 149548 Da
Cofactor: Ascorbate (By similarity)
Cofactor: Fe(2+) (By similarity)
Subunit: Interacts with TLE1 and TLE2 (By similarity)
2 PDB 3D structures from and Proteopedia for UTY:
3ZLI (3D)        3ZPO (3D)    
Secondary accessions: A8K9Z3 E1U199 E1U1A0 F5H4V7 F8W8R7 O14608
Alternative splicing: 5 isoforms:  O14607-1   O14607-2   O14607-3   O14607-4   O14607-5   

Explore the universe of human proteins at neXtProt for UTY: NX_O14607

Explore proteomics data for UTY at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UTY (O14607) (see all 16)
     YQRYYSLQ  IGKVQDAF  ASSPSSAIST  GTCDKVNNIHP 


    See UTY Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (25 alternative transcripts): 
    NP_001245178.1  NP_001245179.1  NP_001245180.1  NP_001245181.1  NP_001245182.1  NP_001245183.1  NP_001245184.1  NP_001245185.1  
    NP_001245186.1  NP_001245187.1  NP_001245188.1  NP_001245189.1  NP_001245190.1  NP_001245191.1  NP_001245192.1  NP_001245193.1  
    NP_001245194.1  NP_001245195.1  NP_001245196.1  NP_001245197.1  NP_001245198.1  NP_001245199.1  NP_009056.3  NP_872600.1  
    NP_872601.1  

    ENSEMBL proteins: 
     ENSP00000328939   ENSP00000355420   ENSP00000330446   ENSP00000372349   ENSP00000372352  
     ENSP00000439922   ENSP00000445274   ENSP00000441943   ENSP00000442047  

    UTY Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for UTY
    GenScript Custom Purified and Recombinant Proteins Services for UTY
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UTY

    UTY Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of UTY
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UTY
    Novus Biologicals UTY Antibodies
    Abcam antibodies for UTY
    Cloud-Clone Corp. Antibodies for UTY
    ThermoFisher Antibodies for UTY
    LSBio Antibodies in human, mouse, rat for UTY

    UTY Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UTY
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UTY
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UTY
    Cloud-Clone Corp. CLIAs for UTY


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR003347 JmjC_dom
     IPR001440 TPR_1
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry O14607

    ProtoNet protein and cluster: O14607

    1 Blocks protein domain: IPB003347 Transcription factor jumonji

    UniProtKB/Swiss-Prot: UTY_HUMAN, O14607
    Similarity: Belongs to the UTX family
    Similarity: Contains 1 JmjC domain
    Similarity: Contains 8 TPR repeats


    UTY for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UTY_HUMAN, O14607
    Function: Histone demethylase (By similarity)

         Genatlas biochemistry entry for UTY:
    ubiquitously transcribed tetratricopeptide repeat (TPR) gene on chromosome Y,with several alternatively spliced
    isoforms,ubiquitous in a AZF deleted region

         Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.112

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA--
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
    GO:0051864histone demethylase activity (H3-K36 specific) IEA--
         
    UTY for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Uty):
     cardiovascular system  homeostasis/metabolism  mortality/aging  muscle  normal 

    UTY for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UTY
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UTY

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UTY
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UTY

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat UTY using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UTY (see all 34):
    hsa-miR-576-3p hsa-miR-4328 hsa-miR-371-5p hsa-miR-298 hsa-miR-3148 hsa-miR-4280 hsa-miR-3163 hsa-miR-455-5p
    SwitchGear 3'UTR luciferase reporter plasmidUTY 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UTY
    Predesigned siRNA for gene silencing in human, mouse, rat UTY

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UTY

    Clone
    Products:
         
    OriGene clones in human, mouse for UTY (see all 17)
    OriGene ORF clones in mouse, rat for UTY
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): UTY (NM_001128425)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UTY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTY

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UTY
    Browse ESI BIO Cell Lines and PureStem Progenitors for UTY 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTY


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UTY_HUMAN, O14607: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    UTY for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UTY About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for UTY):
        Transcriptional misregulation in cancer


    UTY for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UTY
    Interactions:

        Search GeneGlobe Interaction Network for UTY

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UTY (O146073 ENSP000003289394) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCOA6Q146863, ENSP000003518944I2D: score=1 STRING: ENSP00000351894
    TLE1Q047243, ENSP000003656824I2D: score=3 STRING: ENSP00000365682
    TLE2Q047253, ENSP000002629534I2D: score=3 STRING: ENSP00000262953
    SLC2A14ENSP000003404504STRING: ENSP00000340450
    SEC16AENSP000003258274STRING: ENSP00000325827
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0007507heart development IEA--
    GO:0031935regulation of chromatin silencing IEA--
    GO:0045184establishment of protein localization IEA--
    GO:0060070canonical Wnt signaling pathway IEA--

    UTY for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UTY



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UTY gene (25 alternative transcripts): 
    NM_001258249.1  NM_001258250.1  NM_001258251.1  NM_001258252.1  NM_001258253.1  NM_001258254.1  NM_001258255.1  NM_001258256.1  
    NM_001258257.1  NM_001258258.1  NM_001258259.1  NM_001258260.1  NM_001258261.1  NM_001258262.1  NM_001258263.1  NM_001258264.1  
    NM_001258265.1  NM_001258266.1  NM_001258267.1  NM_001258268.1  NM_001258269.1  NM_001258270.1  NM_007125.4  NM_182659.1  
    NM_182660.1  

    Unigene Cluster for UTY:

    Ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
    Hs.115277  [show with all ESTs]
    Unigene Representative Sequence: NR_047607
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331397(uc022cjj.1 uc022cjk.1 uc004fsx.1 uc022cjl.1 uc022cjm.1 uc022cjn.1 uc022cjo.1 uc022cjp.1 uc022cjq.1 uc022cjr.1 uc022cjs.1 uc022cjt.1 uc022cju.1 uc022cjv.1 uc022cjw.1 uc022cjx.1 uc022cjy.1 uc022cjz.1 uc022cka.1 uc022ckb.1 uc022ckc.1 uc022ckd.1 uc022cke.1 uc022ckf.1 uc022ckg.1 uc022ckh.1 uc022cki.1 uc022ckj.1 uc022ckk.1 uc022ckl.1 uc022ckm.1 uc022ckn.1 uc022cko.1 uc022ckp.1 uc022ckq.1 uc022ckr.1 uc022cks.1 uc022ckt.1 uc022cku.1 uc022ckv.1 uc022ckw.1 uc022ckx.1 uc022cky.1 uc022ckz.1 uc022cla.1 uc022clb.1)
    ENST00000362096(uc022clc.1 uc022cld.1 uc022cle.1 uc022clf.1 uc022clg.1 uc022clh.1 uc022cli.1 uc022clj.1 uc022clk.1 uc022cll.1 uc022clm.1 uc022cln.1 uc022clo.1 uc022clp.1 uc022clq.1 uc004fsy.3 uc022clr.1 uc022cls.1 uc022clt.1 uc022clu.1 uc022clv.1 uc022clw.1 uc022clx.1 uc022cly.1 uc022clz.1)
    ENST00000329134(uc022cma.1 uc022cmb.1 uc022cmc.1 uc022cmd.1 uc022cme.1 uc022cmf.1 uc022cmg.1 uc022cmh.1 uc022cmi.1 uc022cmj.1 uc022cmk.1 uc022cml.1 uc022cmm.1 uc022cmn.1 uc022cmo.1 uc022cmp.1 uc022cmq.1 uc022cmr.1 uc022cms.1 uc022cmt.1 uc022cmu.1 uc022cmv.1 uc022cmw.1 uc022cmx.1 uc022cmy.1 uc022cmz.1 uc022cna.1 uc022cnb.1 uc022cnc.1 uc022cnd.1 uc022cne.1 uc022cnf.1 uc022cng.1 uc022cnh.1 uc004fsz.3 uc022cni.1 uc022cnj.1 uc022cnk.1 uc022cnl.1 uc022cnm.1 uc022cnn.1 uc022cno.1 uc022cnp.1 uc022cnq.1 uc022cnr.1 uc022cns.1 uc022cnt.1 uc022cnu.1 uc022cnv.1 uc022cnw.1 uc022cnx.1 uc022cny.1 uc022cnz.1 uc022coa.1 uc022cob.1 uc022coc.1 uc022cod.1)
    ENST00000478900 ENST00000474365 ENST00000382893 ENST00000479713 ENST00000382896(uc004fsw.1)
    ENST00000537580 ENST00000538878 ENST00000540140 ENST00000545955
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UTY using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UTY (see all 34):
    hsa-miR-576-3p hsa-miR-4328 hsa-miR-371-5p hsa-miR-298 hsa-miR-3148 hsa-miR-4280 hsa-miR-3163 hsa-miR-455-5p
    SwitchGear 3'UTR luciferase reporter plasmidUTY 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UTY
    Predesigned siRNA for gene silencing in human, mouse, rat UTY
    Clone
    Products:
         
    OriGene clones in human, mouse for UTY (see all 17)
    OriGene ORF clones in mouse, rat for UTY
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): UTY (NM_001128425)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UTY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTY
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for UTY
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat UTY
      QuantiTect SYBR Green Assays in human, mouse, rat UTY
      QuantiFast Probe-based Assays in human, mouse, rat UTY

    Additional mRNA sequence: 

    AF000994.1 AF000995.1 AF000996.1 AK292858.1 AK308952.1 AY682463.1 AY730613.1 AY769061.1 
    AY769062.1 AY769063.1 AY769064.1 AY769065.1 AY769066.1 AY769067.1 AY769068.1 AY769069.1 
    AY934848.1 AY934849.1 AY934850.1 AY934851.1 AY934852.1 AY934853.1 AY934854.1 AY934855.1 
    AY934856.1 AY934857.1 BC012581.1 BC029389.1 BC051718.1 BC071744.1 CR936684.1 DQ012094.1 
    DQ140388.1 DQ140389.1 DQ140390.1 DQ341385.1 DQ341386.1 DQ341387.1 DQ345542.1 DQ345543.1 
    DQ345544.1 DQ350456.1 DQ350457.1 DQ350458.1 DQ350459.1 EF491796.1 EF612660.1 EF612661.1 
    EF612662.1 EF612663.1 EF612664.1 EF612665.1 EF612666.1 EF612667.1 EF612668.1 EF612669.1 
    EF612670.1 EF612671.1 EF612672.1 EF612673.1 EF612674.1 EF612675.1 EF612676.1 EF612677.1 
    EF612678.1 EF612679.1 EF612680.1 EF612681.1 EF612682.1 EF612683.1 EF612684.1 EF612685.1 
    EF612686.1 EF612687.1 EF612688.1 EF612689.1 EF612690.1 EF612691.1 EF612692.1 EF612693.1 
    EF612694.1 EF612695.1 EF612696.1 EF612697.1 EF612698.1 EF612699.1 EF653165.1 EF653166.1 
    EF653167.1 EF653168.1 EF653169.1 EF653170.1 EF653171.1 EF653172.1 EF653173.1 EF653174.1 
    EF653175.1 EF653176.1 EF653177.1 EF653178.1 EF653179.1 EF653180.1 EF653181.1 EF653182.1 
    EF653183.1 EF653184.1 EF653185.1 EF653186.1 EF653187.1 EF653188.1 EF653189.1 EF653190.1 
    EF653191.1 EF653192.1 EF653193.1 EF653194.1 EF653195.1 EF653196.1 EF653197.1 EF653198.1 
    EF653199.1 EF653200.1 EF653201.1 EF653202.1 EF653203.1 EF653204.1 EF653205.1 EF653206.1 
    EF653207.1 EF653208.1 EF653209.1 EF653210.1 EF653211.1 EF653212.1 EF653213.1 EF653214.1 
    EF653215.1 EF653216.1 EF653217.1 EF653218.1 EF653219.1 EF653220.1 EF653221.1 EF653222.1 
    EF653223.1 EF653224.1 EF685283.1 EF685284.1 EF685285.1 EF685286.1 EF685287.1 EF685288.1 
    EF685289.1 EF685290.1 EF685291.1 EF685292.1 EF685293.1 EF685294.1 EF685295.1 EF685296.1 
    EF685297.1 EF685298.1 EF685299.1 EF685300.1 EF685301.1 EF685302.1 EF685303.1 EF685304.1 
    EF685305.1 EF685306.1 EF685307.1 EF685308.1 EF685309.1 EF685310.1 EF685311.1 EF685312.1 
    EF685313.1 EF685314.1 EF685315.1 EF685316.1 EF685317.1 EF685318.1 EF685319.1 EF685320.1 
    EF685321.1 EF685322.1 EF685323.1 EF685324.1 EF685325.1 EF685326.1 EF685327.1 EF685328.1 
    EF685329.1 EF685330.1 EF685331.1 EF685332.1 EF685333.1 EF685334.1 EF685335.1 EF685336.1 
    EF685337.1 EF685338.1 EF685339.1 EF685340.1 EF685341.1 EF685342.1 EU026275.1 EU026276.1 
    EU026277.1 EU026278.1 EU026279.1 EU026280.1 EU026281.1 EU026282.1 EU026284.1 EU026285.1 
    EU026286.1 EU026287.1 EU026288.1 EU026289.1 EU026290.1 EU026292.1 EU026293.1 EU026294.1 
    EU026295.1 EU026296.1 EU026297.1 EU026298.1 EU026299.1 EU026300.1 EU026301.1 EU026302.1 
    EU026303.1 EU026304.1 EU026305.1 EU026306.1 EU026307.1 EU026308.1 EU026309.1 EU026310.1 
    EU026311.1 EU026312.1 EU026313.1 EU026314.1 EU026315.1 EU026316.1 EU026317.1 EU026318.1 
    EU026319.1 EU026320.1 EU026321.1 EU026322.1 EU026323.1 EU026324.1 EU026325.1 EU026326.1 
    EU026327.1 EU026328.1 EU026329.1 EU026330.1 EU026331.1 EU026332.1 EU026333.1 EU026334.1 
    EU026335.1 EU026336.1 EU026337.1 EU026338.1 EU026339.1 EU026340.1 EU026341.1 EU026342.1 
    EU026343.1 EU026344.1 EU026345.1 EU026346.1 EU026347.1 EU026348.1 EU026349.1 EU026350.1 
    EU026351.1 EU116343.1 EU116344.1 EU116345.1 EU116346.1 EU116347.1 EU116348.1 EU116349.1 
    EU116350.1 EU116351.1 EU116352.1 EU116353.1 EU163941.1 EU163942.1 EU163943.1 NR_047596.1 
    NR_047597.1 NR_047598.1 NR_047599.1 NR_047600.1 NR_047601.1 NR_047602.1 NR_047603.1 NR_047604.1 
    NR_047605.1 NR_047606.1 NR_047607.1 NR_047608.1 NR_047609.1 NR_047610.1 NR_047611.1 NR_047612.1 
    NR_047613.1 NR_047614.1 NR_047615.1 NR_047616.1 NR_047617.1 NR_047618.1 NR_047619.1 NR_047620.1 
    NR_047621.1 NR_047622.1 NR_047623.1 NR_047624.1 NR_047625.1 NR_047626.1 NR_047627.1 NR_047628.1 
    NR_047629.1 NR_047630.1 NR_047631.1 NR_047632.1 NR_047633.1 NR_047634.1 NR_047635.1 NR_047636.1 
    NR_047637.1 NR_047638.1 NR_047639.1 NR_047640.1 NR_047641.1 NR_047642.1 NR_047643.1 NR_047644.1 
    NR_047645.1 NR_047646.1 NR_047647.1 

    9 DOTS entries:

    DT.75104507  DT.100780965  DT.100780961  DT.101976877  DT.100780964  DT.100780959  DT.100726189  DT.91702098 
    DT.91858928 

    Selected AceView cDNA sequences (see all 51):

    NM_182660 BM955951 CD251200 BX444614 AF000994 CR595226 AA831724 BP354432 
    BX509796 NM_182659 BX090888 NM_007125 CA413286 AF000996 AF000995 BC029389 
    BE672472 BG716611 AW139685 BX437317 AL703945 BC012581 CD640080 BP354464 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    UTY expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTGGGGTG
    UTY Expression
    About this image


    UTY expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Testicular Interstitial Cells Testis Interstitium
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Bone (Muscoskeletal System)
             Bone Marrow
    UTY Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UTY Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.115277
        Custom PCR Arrays for UTY
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for UTY
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat UTY
    QuantiTect SYBR Green Assays in human, mouse, rat UTY
    QuantiFast Probe-based Assays in human, mouse, rat UTY
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTY

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UTY gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uty5 ubiquitously transcribed tetratricopeptide repeat gene, more   --   Y 1096861 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    77(a)
    1 → many
    1(110156336-110230976)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    73(a)
    1 → many
    3(135620858-135783794)
    zebrafish
    (Danio rerio)
    Actinopterygii kdm6a6
    kdm6al6
    lysine (K)-specific demethylase 6A, like
    67(a)
    63(a)
    many ↔ many
    many ↔ many
    9(34746176-34820186) ENSDARG00000061759
    6(59580423-59621279) ENSDARG00000059794
    fruit fly
    (Drosophila melanogaster)
    Insecta CG56403 transcriptional repressor 57(a)   31C3   --
    worm
    (Caenorhabditis elegans)
    Secernentea D2021.13 glucose repression mediator protein 38(a)
    (best of 5)
      X(8592454-8598117)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CYC86
    General transcriptional co-repressor, acts togethe...
    19(a)
    1 → many
    II(462870-465770) YBR112C


    ENSEMBL Gene Tree for UTY (if available)
    TreeFam Gene Tree for UTY (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for UTY gene
    KDM6B2  KDM6A2  
    Selected SIMAP similar genes for UTY using alignment to 260 protein entries:     UTY_HUMAN (see all proteins) (see all similar genes):
    TGM4    pp12301    FAM3A    RTBDN    DKFZp686A03225    EDRF1
    FLJ00047    SUN3    X-linked retinopathy protein    C12orf76    DNMT1    RBM27
    DCTN5    EML2    FAM129C    HAUS1    MEFV    ZNF738

    UTY for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for UTY (see all 1072)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr Y posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs97863781,2
    C--15360167(+) AAATAC/GCTTCT 75 -- ds50011Minor allele frequency- G:0.00WA 2
    rs724875031,2
    C--15364625(-) AAGGCG/ACAGAT 75 -- int11Minor allele frequency- A:0.50NA 2
    rs798008081,2
    C--15366099(+) AATCTA/GCATAA 75 -- int10--------
    rs358285231,2
    C--15372130(+) ACAAAA/CCAACT 75 -- int11Minor allele frequency- C:0.00NA 2
    rs1995958141,2
    C--15372323(+) TACTGA/CATATT 75 -- int10--------
    rs3690690771,2
    C--15373775(+) TTTTGC/TTGTAT 75 -- int10--------
    rs97858901,2
    C,F--15375740(+) atgccG/Atggtg 75 -- int12Minor allele frequency- A:0.50NA WA 4
    rs1137746371,2
    C--15376300(-) GAGGAT/AGTGGA 75 -- int12Minor allele frequency- A:0.00CSA 2
    rs97862111,2
    C,F--15377120(+) gttccG/Atataa 75 -- int13Minor allele frequency- A:0.33NA WA 6
    rs782286871,2
    C,F--15378258(+) GTGTCC/TGTTTG 75 -- int11Minor allele frequency- T:0.50NA 4

    HapMap Linkage Disequilibrium report for UTY (15360259 - 15592553 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for UTY: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UTY
    DNA2.0 Custom Variant and Variant Library Synthesis for UTY

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 400009    OMIM disorders: --

    6 diseases for UTY:    
    About MalaCards
    sertoli cell-only syndrome    male infertility    azoospermia    infertility
    retinoblastoma    melanoma

    2 diseases from the University of Copenhagen DISEASES database for UTY:
    Sertoli cell-only syndrome     Azoospermia

    UTY for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for UTY gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 2.44 2 10751404 (1), 7585962 (1)
    immunodeficiency 0 2 9573291 (1), 9766974 (1)

    Genetic Association Database (GAD): UTY
    Human Genome Epidemiology (HuGE) Navigator: UTY (1 document)

    Export disorders for UTY gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for UTY gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with UTY)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The UTX gene escapes X inactivation in mice and humans. (PubMed id 9499428)1, 3, 9 Greenfield A....Koopman P. (Hum. Mol. Genet. 1998)
    2. Genetic variants of Y chromosome are associated with a protective lipid profile in black men. (PubMed id 18511697)1, 4 Russo P....Cappuccio F.P. (Arterioscler. Thromb. Vasc. Biol. 2008)
    3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    4. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (Nature 2003)
    5. Functional coherence of the human Y chromosome. (PubMed id 9381176)1, 2 Lahn B.T. and Page D.C. (Science 1997)
    6. An H-YDb epitope is encoded by a novel mouse Y chromosome gene. (PubMed id 8944031)1, 3 Greenfield A....Koopman P. (Nat. Genet. 1996)
    7. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    8. Huge splicing frequency in human Y chromosomal UTY gene. (PubMed id 21329462)1 Laaser I....Adamski J. (OMICS 2011)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 7404 HGNC: 12638 AceView: UTY Ensembl:ENSG00000183878 euGenes: HUgn7404
    ECgene: UTY Kegg: 7404 H-InvDB: UTY

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UTY Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for UTY gene:
    Search GeneIP for patents involving UTY

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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