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Aliases for UTY Gene

Aliases for UTY Gene

  • Ubiquitously Transcribed Tetratricopeptide Repeat Containing, Y-Linked 2 3 5
  • Ubiquitously-Transcribed Y Chromosome Tetratricopeptide Repeat Protein 3 4
  • Ubiquitously Transcribed Tetratricopeptide Repeat Gene, Y Chromosome 2 3
  • Ubiquitously Transcribed Tetratricopeptide Repeat Gene, Y-Linked 2 3
  • Ubiquitously-Transcribed TPR Protein On The Y Chromosome 3 4
  • KDM6C 3 4
  • Ubiquitously Transcribed TPR Gene On Y Chromosome 3
  • Ubiquitous TPR Motif Protein UTY 3
  • Histone Demethylase UTY 3
  • EC 1.14.11.- 4
  • EC 1.14.11 61
  • KDM6AL 3
  • UTY1 3

External Ids for UTY Gene

Previous GeneCards Identifiers for UTY Gene

  • GC0YM014678
  • GC0YM014368
  • GC0YM013798
  • GC0YM015360
  • GC0YM010010

Summaries for UTY Gene

Entrez Gene Summary for UTY Gene

  • This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. The encoded protein is also a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. A large number of alternatively spliced transcripts have been observed for this gene, but the full length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2012]

GeneCards Summary for UTY Gene

UTY (Ubiquitously Transcribed Tetratricopeptide Repeat Containing, Y-Linked) is a Protein Coding gene. Diseases associated with UTY include Kabuki Syndrome 1. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Transcriptional misregulation in cancer. GO annotations related to this gene include dioxygenase activity and histone demethylase activity (H3-K27 specific). An important paralog of this gene is KDM6A.

UniProtKB/Swiss-Prot for UTY Gene

  • Male-specific histone demethylase that catalyzes trimethylated Lys-27 (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity.

Gene Wiki entry for UTY Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTY Gene

Genomics for UTY Gene

Regulatory Elements for UTY Gene

Enhancers for UTY Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0YF013477 0.4 ENCODE 0.8 +1.4 1366 2.7 POLR2A MAX CEBPB CHD1 UTY PIR33577
GH0YF013475 0.4 ENCODE 0.4 +5.5 5488 0.0 JUN UTY PIR33577
GH0YF013435 1.3 FANTOM5 ENCODE 0.2 +44.5 44450 1.8 CTCF HLF NR2F6 KAT2B TMSB4Y UTY PIR33577
GH0YF013312 0.5 ENCODE 0.1 +167.7 167734 0.8 ZNF652 PIR33577 UTY
GH0YF013295 0.8 ENCODE 0.1 +184.3 184299 1.2 PIR33577 UTY
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UTY on UCSC Golden Path with GeneCards custom track

Genomic Location for UTY Gene

Chromosome:
Y
Start:
13,233,920 bp from pter
End:
13,480,673 bp from pter
Size:
246,754 bases
Orientation:
Minus strand

Genomic View for UTY Gene

Genes around UTY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTY Gene

Proteins for UTY Gene

  • Protein details for UTY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14607-UTY_HUMAN
    Recommended name:
    Histone demethylase UTY
    Protein Accession:
    O14607
    Secondary Accessions:
    • A8K9Z3
    • E1U199
    • E1U1A0
    • F5H4V7
    • F8W8R7
    • O14608

    Protein attributes for UTY Gene

    Size:
    1347 amino acids
    Molecular mass:
    149548 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Cofactor:
    Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
    Quaternary structure:
    • Interacts with TLE1 and TLE2.

    Three dimensional structures from OCA and Proteopedia for UTY Gene

    Alternative splice isoforms for UTY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UTY Gene

Post-translational modifications for UTY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for UTY

Domains & Families for UTY Gene

Graphical View of Domain Structure for InterPro Entry

O14607

UniProtKB/Swiss-Prot:

UTY_HUMAN :
  • Contains 1 JmjC domain.
  • Belongs to the UTX family.
  • Contains 8 TPR repeats.
Domain:
  • Contains 1 JmjC domain.
Family:
  • Belongs to the UTX family.
Similarity:
  • Contains 8 TPR repeats.
genes like me logo Genes that share domains with UTY: view

Function for UTY Gene

Molecular function for UTY Gene

GENATLAS Biochemistry:
ubiquitously transcribed tetratricopeptide repeat (TPR) gene on chromosome Y,with several alternatively spliced isoforms,ubiquitous in a AZF deleted region
UniProtKB/Swiss-Prot Function:
Male-specific histone demethylase that catalyzes trimethylated Lys-27 (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity.

Enzyme Numbers (IUBMB) for UTY Gene

Gene Ontology (GO) - Molecular Function for UTY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0032452 histone demethylase activity TAS --
GO:0046872 metal ion binding IEA --
GO:0051213 dioxygenase activity IEA --
GO:0071558 histone demethylase activity (H3-K27 specific) IEA --
genes like me logo Genes that share ontologies with UTY: view
genes like me logo Genes that share phenotypes with UTY: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UTY

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UTY Gene

Localization for UTY Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTY Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UTY Gene COMPARTMENTS Subcellular localization image for UTY gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for UTY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with UTY: view

Pathways & Interactions for UTY Gene

genes like me logo Genes that share pathways with UTY: view

Pathways by source for UTY Gene

Gene Ontology (GO) - Biological Process for UTY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IEA --
GO:0016569 covalent chromatin modification IEA --
GO:0055114 oxidation-reduction process IEA --
GO:0071557 histone H3-K27 demethylation IEA --
genes like me logo Genes that share ontologies with UTY: view

No data available for SIGNOR curated interactions for UTY Gene

Transcripts for UTY Gene

Unigene Clusters for UTY Gene

Ubiquitously transcribed tetratricopeptide repeat containing, Y-linked:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UTY

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTY Gene

No ASD Table

Relevant External Links for UTY Gene

GeneLoc Exon Structure for
UTY
ECgene alternative splicing isoforms for
UTY

Expression for UTY Gene

mRNA expression in normal human tissues for UTY Gene

Protein differential expression in normal tissues from HIPED for UTY Gene

This gene is overexpressed in Pancreatic juice (41.7) and Heart (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UTY Gene



Protein tissue co-expression partners for UTY Gene

NURSA nuclear receptor signaling pathways regulating expression of UTY Gene:

UTY

SOURCE GeneReport for Unigene cluster for UTY Gene:

Hs.115277
genes like me logo Genes that share expression patterns with UTY: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UTY Gene

Orthologs for UTY Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UTY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTY 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 78 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Uty 35
  • 77 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UTY 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 77 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 73 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii kdm6a 35
  • 67 (a)
ManyToMany
kdm6al 35
  • 63 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5640 36
  • 57 (a)
Utx 35
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea D2021.1 36
  • 38 (a)
F18E9.5a 36
  • 31 (a)
F18E9.5b 36
  • 31 (a)
utx-1 35
  • 30 (a)
OneToMany
F23D12.5 36
  • 28 (a)
C29F7.6 36
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CYC8 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8580 35
  • 42 (a)
OneToMany
Species where no ortholog for UTY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UTY Gene

ENSEMBL:
Gene Tree for UTY (if available)
TreeFam:
Gene Tree for UTY (if available)

Paralogs for UTY Gene

Paralogs for UTY Gene

(173) SIMAP similar genes for UTY Gene using alignment to 260 proteins:

genes like me logo Genes that share paralogs with UTY: view

Variants for UTY Gene

Sequence variations from dbSNP and Humsavar for UTY Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs10465454 -- 13,437,170(+) gccac(C/T)taaga intron-variant
rs111233794 -- 13,450,410(+) ACTAG(A/G)CCCAC intron-variant
rs111236243 -- 13,305,252(+) TTAAG(A/G)GTAAT intron-variant, downstream-variant-500B
rs111237887 -- 13,365,872(+) TTATT(C/T)ATTTA intron-variant
rs111330318 -- 13,314,331(+) ATGGC(A/C)TGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UTY Gene

Variant ID Type Subtype PubMed ID
nsv1141114 CNV deletion 24896259

Variation tolerance for UTY Gene

Gene Damage Index Score: 0.33; 7.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTY Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTY Gene

Disorders for UTY Gene

MalaCards: The human disease database

(1) MalaCards diseases for UTY Gene - From: DISEASES

Disorder Aliases PubMed IDs
kabuki syndrome 1
  • kabuki syndrome
- elite association - COSMIC cancer census association via MalaCards
Search UTY in MalaCards View complete list of genes associated with diseases

Relevant External Links for UTY

Genetic Association Database (GAD)
UTY
Human Genome Epidemiology (HuGE) Navigator
UTY
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTY
genes like me logo Genes that share disorders with UTY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UTY Gene

Publications for UTY Gene

  1. The UTX gene escapes X inactivation in mice and humans. (PMID: 9499428) Greenfield A. … Koopman P. (Hum. Mol. Genet. 1998) 2 3 22 64
  2. Human UTY(KDM6C) is a male-specific N-methyl lysyl demethylase. (PMID: 24798337) Walport L.J. … Johansson C. (J. Biol. Chem. 2014) 3 4 64
  3. Genetic variants of Y chromosome are associated with a protective lipid profile in black men. (PMID: 18511697) Russo P. … Cappuccio F.P. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 46 64
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64
  5. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 3 4 64

Products for UTY Gene

Sources for UTY Gene

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