UTS2R Gene
protein-coding GIFtS: 56
GCID: GC17P080332
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urotensin 2 receptor(Previous name: G protein-coupled receptor 14 ) (Previous symbol: GPR14)
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Aliases for UTS2R gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Urotensin 2 Receptor1 2 | | UR-II-R2 3 | | GPR141 2 3 5 | | G-Protein Coupled Receptor 142 3 | | G Protein-Coupled Receptor 141 2 | | UTR2 5 | | Urotensin II Receptor2 3 | | UTR22 5 | | UR-2-R2 3 | | Urotensin-2 Receptor2 |
Export aliases for UTS2R gene to outside databasesPrevious GC identifers: GC17P077925 GC17P075730 |
Summaries for UTS2R gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: UR2R_HUMAN, Q9UKP6Function: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by aG-protein that activate a phosphatidylinositol-calcium second messenger system
summary
for UTS2R: Urotensin-II (UT) receptors are Gq/11-protein-coupled receptors that mediate complex hemodynamic effects and influence neuromuscular physiology. UT receptors display greatest expression levels in the peripheral vasculature, heart and kidney, although they are found in other tissues, notably the central nervous system, at lower levels. UT receptors produce potent but variable vasoconstrictor effects in some vascular beds yet mediate vasodilation in others and they have also been implicated in osmoregulation. The human gene encoding the UT receptor is located on chromosome 17q25.3. Gene Wiki entry for UTS2R (Urotensin-II receptor)
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Genomic Views for UTS2R gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010663.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the UTS2R gene promoter: Bach2 SREBP-1c MyoD E47 Arnt SREBP-1b PPAR-alpha SREBP-1a FOXJ2 (long isoform) FOXJ2 Other transcription factors
Search SABiosciences Chromatin IP Primers for UTS2R
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UTS2R |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3UTS2R Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P080332: view genomic region
(about GC identifiers)
Start:
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80,332,153 bp from pter |
End:
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80,333,462 bp from pter |
Size:
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1,310 bases |
Orientation:
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plus strand |
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Proteins for UTS2R gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: UR2R_HUMAN, Q9UKP6 (See
protein sequence)Recommended Name: Urotensin-2 receptor Size: 389 amino acids; 42130 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2RMV8Explore the universe of human proteins at neXtProt for UTS2R: NX_Q9UKP6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UKP6 UTS2R Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061822.1 ENSEMBL proteins: ENSP00000323516 Reactome Protein details: Q9UKP6 Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
UTS2R for ontologies About GeneDecksing
UTS2R Antibody Products: Assay Products for UTS2R: |
Protein
Domains / Families for UTS2R gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UTS2R for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UKP6ProtoNet protein and cluster: Q9UKP6 1 Blocks protein family: IPB000670 SENR orphan receptor signature
UniProtKB/Swiss-Prot: UR2R_HUMAN, Q9UKP6Similarity: Belongs to the G-protein coupled receptor 1 family |
Function for UTS2R gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: UR2R_HUMAN, Q9UKP6Function: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by aG-protein that activate a phosphatidylinositol-calcium second messenger system
Clone Products: |  | EMD Millipore Clones for the Expression of UTS2R | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UTS2R (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UTS2R OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UTS2R (NM_018949) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UTS2R | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTS2R  |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001604 | urotensin II receptor activity |
IEA | -- | | GO:0004930 | G-protein coupled receptor activity |
TAS | 10499587 |
UTS2R for ontologies About GeneDecksing
Animal Models: Mouse knock-out Uts2rtm1Djbe for UTS2R 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Uts2r):
UTS2R for phenotypes About GeneDecksing
|
Pathways & Interactions for UTS2R gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | G alpha (q) signalling events | | | 4 | Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q | | | 5 | GPCRs, Other | |
Pathway sources See GeneCards unified pathways Show all pathways
1 EMD Millipore Pathway for UTS2R
1 BioSystems Pathway for UTS2R 
5/8
Reactome Pathways for UTS2R (see all 8)
1
Kegg Pathway (Kegg details for UTS2R):
UTS2R for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UTS2R
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/123 Interacting proteins for UTS2R (Q9UKP63 ENSP000003235164) via UniProtKB, MINT, STRING, and/or I2D (see all 123)About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table
UTS2R for ontologies About GeneDecksing
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Drugs & Compounds for UTS2R gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
UTS2R for compounds About GeneDecksing
Compounds for UTS2R available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Urotensin II (human) | Endogenous vasoactive agonist for the UT receptor | [251293-28-4] | | (±)-AC 7954 hydrochloride | Non-peptide UT receptor agonist | [477313-09-0] | | SB 657510 | Selective urotensin-II (UT) receptor antagonist | [474960-44-6] | | BIM 23127 | NMB receptor antagonist. Also U-II receptor antagonist | [160161-61-5] | | [Orn5]-URP | Urotensin-II (UT) receptor antagonist | -- |
1 HMDB Compound for UTS2R About this table 3 Novoseek chemical compound relationships for UTS2R gene About this table
Search CenterWatch for drugs/clinical trials and news about UTS2R / UR2R 
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Transcripts for UTS2R gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for UTS2R gene: NM_018949.1 Unigene Cluster for UTS2R: Urotensin 2 receptor Hs.192720 [show with all ESTs]Unigene Representative Sequence: BC1364901 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000313135(uc010wvl.2)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UTS2R (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UTS2R OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UTS2R (NM_018949) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UTS2R | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTS2R  |
Additional cDNA sequence: BC136490.1 1 DOTS entry: DT.437824 7 AceView cDNA sequences: NM_018949 BF513269 BF732711 AI263529 AA933596 BF733007 AA992531 GeneLoc Exon Structure
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Expression for UTS2R gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UTS2R expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CGGCTGGTGC
About this image See UTS2R Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for UTS2R
SOURCE GeneReport for Unigene cluster: Hs.192720 UniProtKB/Swiss-Prot: UR2R_HUMAN, Q9UKP6Tissue specificity: Most abundant expression in the heart and pancreas SABiosciences Expression via Pathway-Focused PCR Arrays including UTS2R:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UTS2R Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UTS2R | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UTS2R | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UTS2R |
Orthologs for UTS2R gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for UTS2R gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for UTS2R (if available) TreeFam Gene Tree for UTS2R (if available)  |
Paralogs for UTS2R gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for UTS2R gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 17 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for UTS2R (80332153 - 80333462 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for UTS2R 2 CNVs: 5043 73078  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UTS2R |
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Disorders
/ Diseases for UTS2R gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UTS2R for disorders About GeneDecksing
OMIM gene information: 600896
OMIM disorders: --
17 diseases for UTS2R: About MalaCardstype 2 diabetes mellitus portal hypertension diabetes mellitus insulin resistance pheochromocytoma rhabdomyosarcoma nephropathy hermaphroditism aldosteronism hypertension cardiomyopathy prostate cancer atherosclerosis hypoxia prostatitis adenocarcinoma neuronitis
8 Novoseek disease relationships for UTS2R gene About this table
Human Genome Epidemiology (HuGE) Navigator: UTS2R (2 documents) Export disorders for UTS2R gene to outside databases
|
Publications for UTS2R gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UTS2R gene, integrated from 9 sources (see all 94): (articles sorted by number of sources associating them with UTS2R) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. (PubMed id 10499587)1, 2, 3, 9 Ames R.S....Douglas S.A. (1999)
- Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. (PubMed id 8666380)1, 3, 9 Marchese A.... Docherty J.M. (1995)
- Identification of urotensin II-related peptide as the urotensin II- immunoreactive molecule in the rat brain. (PubMed id 14550283)1, 2, 9 Sugo T.... Fujino M. (2003)
- Immunolocalization of urotensin II and its receptor in human adrenal tumors and attached non-neoplastic adrenal tissues. (PubMed id 17686550)1, 9 Morimoto R....Takahashi K. (2008)
- Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese. (PubMed id 15476949)1, 9 Suzuki S....Oka Y. (2004)
- Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14. (PubMed id 10581185)1, 9 Liu Q....Caskey C.T. (1999)
- Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta. (PubMed id 15306183)1, 9 Bousette N....Giaid A. (2004)
- Increased expression of urotensin II and GPR14 in pat ients with cirrhosis and portal hypertension. (PubMed id 20428787)1, 9 Liu D....Wang Y. (2010)
- Ligands and signaling of the G-protein-coupled receptor GPR14, expressed in human kidney cells. (PubMed id 17595527)1, 9 Lehner U....Sindic A. (2007)
- The expression of urotensin II receptor (U2R) is up-regulated by interferon-gamma. (PubMed id 14753294)1, 9 Birker-Robaczewska M....Nayler O. (2003)
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External Searches for UTS2R gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing UTS2R gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UTS2R gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UTS2R gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for UTS2R | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for UTS2R gene: Search GeneIP for patents involving UTS2R
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products for UTS2R gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for UTS2R | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UTS2R | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UTS2R | | OriGene Protein Over-expression Lysate for UTS2R | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for UTS2R | | Browse 3'-UTR reporter clones for miRNA target validation | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UTS2R | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UTS2R | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UTS2R | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UTS2R | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UTS2R | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UTS2R | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UTS2R | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UTS2R |
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 | | UTS2R Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | Search ThermoFisher Antibodies for UTS2R |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTS2R |
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