Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UTS2R Gene

Aliases for UTS2R Gene

  • Urotensin 2 Receptor 2 3 5
  • G Protein-Coupled Receptor 14 2 3
  • G-Protein Coupled Receptor 14 3 4
  • Urotensin II Receptor 3 4
  • UR-II-R 3 4
  • UR-2-R 3 4
  • GPR14 3 4
  • UTR2 3
  • UTR 3

External Ids for UTS2R Gene

Previous HGNC Symbols for UTS2R Gene

  • GPR14

Previous GeneCards Identifiers for UTS2R Gene

  • GC17P077925
  • GC17P080332
  • GC17P075730

Summaries for UTS2R Gene

GeneCards Summary for UTS2R Gene

UTS2R (Urotensin 2 Receptor) is a Protein Coding gene. Diseases associated with UTS2R include Portal Hypertension and Amyotrophic Lateral Sclerosis 3. Among its related pathways are Peptide ligand-binding receptors and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and urotensin II receptor activity.

UniProtKB/Swiss-Prot for UTS2R Gene

  • High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for UTS2R Gene

  • The urotensin-II (UT) receptor is a Gq/11-protein-coupled receptor that mediates complex hemodynamic effects and influences neuromuscular physiology. The UT receptor displays greatest expression levels in the peripheral vasculature, heart and kidney.

Gene Wiki entry for UTS2R Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTS2R Gene

Genomics for UTS2R Gene

Regulatory Elements for UTS2R Gene

Enhancers for UTS2R Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UTS2R on UCSC Golden Path with GeneCards custom track

Genomic Location for UTS2R Gene

Chromosome:
17
Start:
82,374,230 bp from pter
End:
82,375,586 bp from pter
Size:
1,357 bases
Orientation:
Plus strand

Genomic View for UTS2R Gene

Genes around UTS2R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTS2R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTS2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTS2R Gene

Proteins for UTS2R Gene

  • Protein details for UTS2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKP6-UR2R_HUMAN
    Recommended name:
    Urotensin-2 receptor
    Protein Accession:
    Q9UKP6
    Secondary Accessions:
    • B2RMV8

    Protein attributes for UTS2R Gene

    Size:
    389 amino acids
    Molecular mass:
    42130 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UTS2R Gene

Proteomics data for UTS2R Gene at MOPED

Post-translational modifications for UTS2R Gene

  • Glycosylation at Asn 29 and Asn 33
  • Modification sites at PhosphoSitePlus

Other Protein References for UTS2R Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for UTS2R Gene

Domains & Families for UTS2R Gene

Gene Families for UTS2R Gene

IUPHAR :

Protein Domains for UTS2R Gene

Suggested Antigen Peptide Sequences for UTS2R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKP6

UniProtKB/Swiss-Prot:

UR2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with UTS2R: view

Function for UTS2R Gene

Molecular function for UTS2R Gene

UniProtKB/Swiss-Prot Function:
High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
genes like me logo Genes that share phenotypes with UTS2R: view

Animal Models for UTS2R Gene

MGI Knock Outs for UTS2R:

Animal Model Products

  • Taconic Biosciences Mouse Models for UTS2R

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for UTS2R Gene

Localization for UTS2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTS2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UTS2R Gene COMPARTMENTS Subcellular localization image for UTS2R gene
Compartment Confidence
plasma membrane 5
cytosol 2
endosome 2

Gene Ontology (GO) - Cellular Components for UTS2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0016020 membrane TAS 8666380
genes like me logo Genes that share ontologies with UTS2R: view

Pathways & Interactions for UTS2R Gene

genes like me logo Genes that share pathways with UTS2R: view

Pathways by source for UTS2R Gene

Gene Ontology (GO) - Biological Process for UTS2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003105 negative regulation of glomerular filtration IEA --
GO:0007165 signal transduction TAS 10499587
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA --
GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness IEA --
genes like me logo Genes that share ontologies with UTS2R: view

No data available for SIGNOR curated interactions for UTS2R Gene

Drugs & Compounds for UTS2R Gene

(17) Drugs for UTS2R Gene - From: DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BIM 23127 Pharma Antagonist NMB receptor antagonist. Also U-II receptor antagonist 0
palosuran Pharma Antagonist 0
[<sup>125</sup>I]U-II (human) Pharma Full agonist, Agonist 0
[Bz-Phe6]U-II (human) Pharma Full agonist, Agonist 0
[Pen5]-U (4-11) (human) Pharma Full agonist, Agonist 0

(5) Additional Compounds for UTS2R Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-AC 7954 hydrochloride
477313-09-0
[Orn5]-URP
782485-03-4
UFP 803
879497-82-2
Urotensin II (human)
251293-28-4

(5) Tocris Compounds for UTS2R Gene

Compound Action Cas Number
(+-)-AC 7954 hydrochloride Non-peptide UT receptor agonist 477313-09-0
[Orn5]-URP Urotensin-II (UT) receptor antagonist 782485-03-4
BIM 23127 NMB receptor antagonist. Also U-II receptor antagonist 160161-61-5
UFP 803 Urotensin-II (UT) antagonist 879497-82-2
Urotensin II (human) Endogenous vasoactive agonist for the UT receptor 251293-28-4
genes like me logo Genes that share compounds with UTS2R: view

Transcripts for UTS2R Gene

mRNA/cDNA for UTS2R Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UTS2R Gene

Urotensin 2 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UTS2R Gene

No ASD Table

Relevant External Links for UTS2R Gene

GeneLoc Exon Structure for
UTS2R
ECgene alternative splicing isoforms for
UTS2R

Expression for UTS2R Gene

mRNA expression in normal human tissues for UTS2R Gene

mRNA differential expression in normal tissues according to GTEx for UTS2R Gene

This gene is overexpressed in Testis (x14.5), Thyroid (x4.5), and Heart - Atrial Appendage (x4.1).

Protein differential expression in normal tissues from HIPED for UTS2R Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UTS2R Gene



SOURCE GeneReport for Unigene cluster for UTS2R Gene Hs.192720

mRNA Expression by UniProt/SwissProt for UTS2R Gene

Q9UKP6-UR2R_HUMAN
Tissue specificity: Most abundant expression in the heart and pancreas.
genes like me logo Genes that share expression patterns with UTS2R: view

Protein tissue co-expression partners for UTS2R Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for UTS2R Gene

Orthologs for UTS2R Gene

This gene was present in the common ancestor of animals.

Orthologs for UTS2R Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UTS2R 35
  • 80.6 (n)
  • 73.81 (a)
UTS2R 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UTS2R 35
  • 82.26 (n)
  • 76.74 (a)
UTS2R 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uts2r 35
  • 78.71 (n)
  • 78.17 (a)
Uts2r 16
Uts2r 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UTS2R 35
  • 99.14 (n)
  • 98.71 (a)
UTS2R 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uts2r 35
  • 78.23 (n)
  • 77.42 (a)
oppossum
(Monodelphis domestica)
Mammalia UTS2R 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UTS2R 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves UTS2R 35
  • 65.12 (n)
  • 57.77 (a)
UTS2R 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UTS2R 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485936 35
  • 67.55 (n)
  • 60 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC559133 35
  • 59.96 (n)
  • 55.59 (a)
UTS2R 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea npr-16 36
  • 18 (a)
OneToOne
Species with no ortholog for UTS2R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTS2R Gene

ENSEMBL:
Gene Tree for UTS2R (if available)
TreeFam:
Gene Tree for UTS2R (if available)

Paralogs for UTS2R Gene

(6) SIMAP similar genes for UTS2R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UTS2R: view

No data available for Paralogs for UTS2R Gene

Variants for UTS2R Gene

Sequence variations from dbSNP and Humsavar for UTS2R Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_035768 A breast cancer sample
rs34442190 - 82,374,532(+) GCAAC(A/C/G)CCTAC reference, missense
rs6502104 -- 82,373,902(+) GCGCA(A/C)TGGGC upstream-variant-2KB
rs7211350 -- 82,373,590(+) TAAGA(A/G)ATATT upstream-variant-2KB
rs7502317 -- 82,376,017(+) GGTAG(A/G)GGGTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for UTS2R Gene

Variant ID Type Subtype PubMed ID
nsv428351 CNV Gain 18775914
dgv3332n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3341n71 CNV Loss 21882294
dgv3353n71 CNV Loss 21882294
dgv3354n71 CNV Loss 21882294
nsv833572 CNV Loss 17160897
nsv909208 CNV Loss 21882294
nsv469561 CNV Complex 16826518
dgv3356n71 CNV Loss 21882294
nsv909217 CNV Loss 21882294
nsv833573 CNV Loss 17160897
dgv3357n71 CNV Loss 21882294
nsv909220 CNV Loss 21882294
dgv3358n71 CNV Loss 21882294
nsv909223 CNV Loss 21882294
dgv3359n71 CNV Loss 21882294
nsv909227 CNV Loss 21882294

Variation tolerance for UTS2R Gene

Gene Damage Index Score: 2.20; 39.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTS2R Gene

Human Gene Mutation Database (HGMD)
UTS2R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTS2R Gene

Disorders for UTS2R Gene

MalaCards: The human disease database

(4) MalaCards diseases for UTS2R Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
portal hypertension
  • hypertension, portal
amyotrophic lateral sclerosis 3
  • amyotrophic lateral sclerosis type 3
pheochromocytoma
  • pheochromocytoma, modifier of
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search UTS2R in MalaCards View complete list of genes associated with diseases

Relevant External Links for UTS2R

Genetic Association Database (GAD)
UTS2R
Human Genome Epidemiology (HuGE) Navigator
UTS2R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTS2R
genes like me logo Genes that share disorders with UTS2R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UTS2R Gene

Publications for UTS2R Gene

  1. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. (PMID: 10499587) Ames R.S. … Douglas S.A. (Nature 1999) 2 3 4 23 67
  2. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. (PMID: 8666380) Marchese A. … Docherty J.M. (Genomics 1995) 2 3 23
  3. Increased expression of urotensin II and GPR14 in patients with cirrhosis and portal hypertension. (PMID: 20428787) Liu D. … Wang Y. (Int. J. Mol. Med. 2010) 3 23
  4. Immunolocalization of urotensin II and its receptor in human adrenal tumors and attached non-neoplastic adrenal tissues. (PMID: 17686550) Morimoto R. … Takahashi K. (Peptides 2008) 3 23
  5. Immunocytochemical localization of the urotensin-II receptor, UT, to rat and human tissues: relevance to function. (PMID: 17905478) Maguire J.J. … Davenport A.P. (Peptides 2008) 3 23

Products for UTS2R Gene

Sources for UTS2R Gene

Content