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Aliases for UTS2R Gene

Aliases for UTS2R Gene

  • Urotensin 2 Receptor 2 3
  • GPR14 3 4 6
  • G Protein-Coupled Receptor 14 2 3
  • G-Protein Coupled Receptor 14 3 4
  • Urotensin II Receptor 3 4
  • UR-II-R 3 4
  • UR-2-R 3 4
  • UTR2 3 6
  • UTR 3 6
  • Urotensin-2 Receptor 3

External Ids for UTS2R Gene

Previous Symbols for UTS2R Gene

  • GPR14

Summaries for UTS2R Gene

GeneCards Summary for UTS2R Gene

UTS2R (Urotensin 2 Receptor) is a Protein Coding gene. Diseases associated with UTS2R include pheochromocytoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and urotensin II receptor activity.

UniProtKB/Swiss-Prot for UTS2R Gene

  • High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for UTS2R Gene

  • Urotensin-II (UT) receptors are Gq/11-protein-coupled receptors that mediate complex hemodynamic effects and influence neuromuscular physiology. UT receptors display greatest expression levels in the peripheral vasculature, heart and kidney, although they are found in other tissues, notably the central nervous system, at lower levels. UT receptors produce potent but variable vasoconstrictor effects in some vascular beds yet mediate vasodilation in others and they have also been implicated in osmoregulation. The human gene encoding the UT receptor is located on chromosome 17q25.3.

Gene Wiki entry for UTS2R Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTS2R Gene

Genomics for UTS2R Gene

Genomic Location for UTS2R Gene

Start:
82,374,230 bp from pter
End:
82,375,586 bp from pter
Size:
1,357 bases
Orientation:
Plus strand

Genomic View for UTS2R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UTS2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTS2R Gene

Regulatory Elements for UTS2R Gene

Proteins for UTS2R Gene

  • Protein details for UTS2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKP6-UR2R_HUMAN
    Recommended name:
    Urotensin-2 receptor
    Protein Accession:
    Q9UKP6
    Secondary Accessions:
    • B2RMV8

    Protein attributes for UTS2R Gene

    Size:
    389 amino acids
    Molecular mass:
    42130 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UTS2R Gene

Proteomics data for UTS2R Gene at MOPED

Post-translational modifications for UTS2R Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn29 and Asn33

Other Protein References for UTS2R Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for UTS2R Gene

Domains for UTS2R Gene

Gene Families for UTS2R Gene

Protein Domains for UTS2R Gene

UniProtKB/Swiss-Prot:

UR2R_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q9UKP6
genes like me logo Genes that share domains with UTS2R: view

Function for UTS2R Gene

Molecular function for UTS2R Gene

UniProtKB/Swiss-Prot Function: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.

Gene Ontology (GO) - Molecular Function for UTS2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001604 urotensin II receptor activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 10499587
genes like me logo Genes that share ontologies with UTS2R: view

Phenotypes for UTS2R Gene

genes like me logo Genes that share phenotypes with UTS2R: view

Animal Models for UTS2R Gene

MGI Knock Outs for UTS2R:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for UTS2R Gene

Localization for UTS2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTS2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UTS2R Gene COMPARTMENTS Subcellular localization image for UTS2R gene
Compartment Confidence
plasma membrane 5
endosome 2

Gene Ontology (GO) - Cellular Components for UTS2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 8666380
GO:0016021 integral component of membrane IEA --
GO:0055037 recycling endosome IEA --
genes like me logo Genes that share ontologies with UTS2R: view

Pathways for UTS2R Gene

genes like me logo Genes that share pathways with UTS2R: view

Pathways by source for UTS2R Gene

Gene Ontology (GO) - Biological Process for UTS2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003105 negative regulation of glomerular filtration IEA --
GO:0007165 signal transduction TAS 10499587
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0008015 blood circulation TAS 10499587
genes like me logo Genes that share ontologies with UTS2R: view

Compounds for UTS2R Gene

(5) Tocris Compounds for UTS2R Gene

Compound Action Cas Number
(+-)-AC 7954 hydrochloride Non-peptide UT receptor agonist [477313-09-0]
[Orn8]-Urotensin II Urotensin-II (UT) receptor partial agonist [479065-85-5]
SB 657510 Selective urotensin-II (UT) receptor antagonist [474960-44-6]
SB 706375 High affinity, non-peptide UT receptor antagonist [733734-61-7]
Urotensin II (human) Endogenous vasoactive agonist for the UT receptor [251293-28-4]

(1) HMDB Compounds for UTS2R Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(18) IUPHAR Ligand for UTS2R Gene

Ligand Type Action Affinity Pubmed IDs
[Pen5]-U (4-11) (human) Agonist Full agonist 9.7
[125I]U-II (human) Agonist Full agonist 9.62
U-II-(4-11) (human) Agonist Full agonist 9.6
urotensin-related peptide None None 9.6
[Bz-Phe6]U-II (human) Agonist Full agonist 9.1
urotensin-II Agonist Full agonist 8.6
urotensin-II Agonist Full agonist 8.6
urotensin-II Agonist Full agonist 8.6
4-Cl-cinnamoyl-c[DCys-4Pal-DTrp-Orn-Val-Cys]-His-amide Antagonist Inverse agonist 8.4
urantide Antagonist Antagonist 8.3
SB-706375 Antagonist Antagonist 8
tolyacetyl-c[DCys-Apa-DTrp-Orn-Val-Cys]-His-amide Antagonist Antagonist 7.7
FL104 Agonist Full agonist 7.5
palosuran Antagonist Antagonist 7.1
BIM 23127 Antagonist Antagonist 6.7
AC-7954 Agonist Full agonist 6.6
SB-611812 Antagonist Antagonist 6.6
S6716 Antagonist Inverse agonist 6.4

(3) Novoseek inferred chemical compound relationships for UTS2R Gene

Compound -log(P) Hits PubMed IDs
palosuran 95.2 6
calcium 19.5 5
glucose 0 3
genes like me logo Genes that share compounds with UTS2R: view

Transcripts for UTS2R Gene

mRNA/cDNA for UTS2R Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UTS2R Gene

Urotensin 2 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UTS2R Gene

No ASD Table

Relevant External Links for UTS2R Gene

GeneLoc Exon Structure for
UTS2R
ECgene alternative splicing isoforms for
UTS2R

Expression for UTS2R Gene

mRNA expression in normal human tissues for UTS2R Gene

mRNA differential expression in normal tissues according to GTEx for UTS2R Gene

This gene is overexpressed in Testis (14.5), Thyroid (4.5), and Heart - Atrial Appendage (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UTS2R Gene

SOURCE GeneReport for Unigene cluster for UTS2R Gene Hs.192720

mRNA Expression by UniProt/SwissProt for UTS2R Gene

Q9UKP6-UR2R_HUMAN
Tissue specificity: Most abundant expression in the heart and pancreas
genes like me logo Genes that share expressions with UTS2R: view

Orthologs for UTS2R Gene

This gene was present in the common ancestor of animals.

Orthologs for UTS2R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTS2R 36
  • 99.14 (n)
  • 98.71 (a)
UTS2R 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UTS2R 36
  • 80.6 (n)
  • 73.81 (a)
UTS2R 37
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UTS2R 36
  • 82.26 (n)
  • 76.74 (a)
UTS2R 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uts2r 36
  • 78.71 (n)
  • 78.17 (a)
Uts2r 16
Uts2r 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UTS2R 37
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UTS2R 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uts2r 36
  • 78.23 (n)
  • 77.42 (a)
chicken
(Gallus gallus)
Aves UTS2R 36
  • 65.12 (n)
  • 57.77 (a)
UTS2R 37
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UTS2R 37
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485936 36
  • 67.55 (n)
  • 60 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC559133 36
  • 59.96 (n)
  • 55.59 (a)
UTS2R 37
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea npr-16 37
  • 18 (a)
OneToOne
Species with no ortholog for UTS2R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTS2R Gene

ENSEMBL:
Gene Tree for UTS2R (if available)
TreeFam:
Gene Tree for UTS2R (if available)

Paralogs for UTS2R Gene

Selected SIMAP similar genes for UTS2R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UTS2R: view

No data available for Paralogs for UTS2R Gene

Variants for UTS2R Gene

Sequence variations from dbSNP and Humsavar for UTS2R Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs6502104 -- 82,373,902(+) GCGCA(A/C)TGGGC upstream-variant-2KB
rs7211350 -- 82,373,590(+) TAAGA(A/G)ATATT upstream-variant-2KB
rs11077991 -- 82,372,898(+) ggaaa(C/G)ggcag upstream-variant-2KB
rs11650469 -- 82,372,800(+) agagt(A/G)gaatt upstream-variant-2KB
rs11658052 -- 82,372,808(+) attgc(C/T)gggtg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UTS2R Gene

Variant ID Type Subtype PubMed ID
nsv428351 CNV Gain 18775914
dgv3332n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3341n71 CNV Loss 21882294
dgv3353n71 CNV Loss 21882294
dgv3354n71 CNV Loss 21882294
nsv833572 CNV Loss 17160897
nsv909208 CNV Loss 21882294
nsv469561 CNV Complex 16826518
dgv3356n71 CNV Loss 21882294
nsv909217 CNV Loss 21882294
nsv833573 CNV Loss 17160897
dgv3357n71 CNV Loss 21882294
nsv909220 CNV Loss 21882294
dgv3358n71 CNV Loss 21882294
nsv909223 CNV Loss 21882294
dgv3359n71 CNV Loss 21882294
nsv909227 CNV Loss 21882294

Relevant External Links for UTS2R Gene

HapMap Linkage Disequilibrium report
UTS2R

Disorders for UTS2R Gene

(1) MalaCards Diseases for UTS2R Gene

Search for UTS2R Gene in MalaCards »

(8) Novoseek inferred disease relationships for UTS2R Gene

Disease -log(P) Hits PubMed IDs
coronary atheroma 64 1
rhabdomyosarcoma 49.4 2
effects cardiovascular 48.5 1
pheochromocytoma 34.4 10
diabetic nephropathies 13.7 2

Relevant External Links for UTS2R

Genetic Association Database (GAD)
UTS2R
Human Genome Epidemiology (HuGE) Navigator
UTS2R
genes like me logo Genes that share disorders with UTS2R: view

No data available for UniProtKB/Swiss-Prot for UTS2R Gene

Publications for UTS2R Gene

  1. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. (PMID: 10499587) Ames R.S. … Douglas S.A. (Nature 1999) 2 3 4 23
  2. Identification of urotensin II-related peptide as the urotensin II- immunoreactive molecule in the rat brain. (PMID: 14550283) Sugo T. … Fujino M. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  3. Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance. (PMID: 16597476) Ong K.L. … Cheung B.M. (Peptides 2006) 3 23 49
  4. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. (PMID: 8666380) Marchese A. … Docherty J.M. (Genomics 1995) 2 3 23
  5. Increased expression of urotensin II and GPR14 in patients with cirrhosis and portal hypertension. (PMID: 20428787) Liu D. … Wang Y. (Int. J. Mol. Med. 2010) 3 23

Products for UTS2R Gene

Sources for UTS2R Gene

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