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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UTS2R Gene

protein-coding   GIFtS: 59
GCID: GC17P080332

Urotensin 2 Receptor

(Previous name: G protein-coupled receptor 14)
(Previous symbol: GPR14)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Urotensin 2 Receptor1 2     UR-II-R2 3
GPR141 2 3 5     G-Protein Coupled Receptor 142 3
G Protein-Coupled Receptor 141 2     UTR2 5
Urotensin II Receptor2 3     UTR22 5
UR-2-R2 3     Urotensin-2 Receptor2

External Ids:    HGNC: 44681   Entrez Gene: 28372   Ensembl: ENSG000001814087   OMIM: 6008965   UniProtKB: Q9UKP63   

Export aliases for UTS2R gene to outside databases

Previous GC identifers: GC17P077925 GC17P075730


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UTS2R Gene: 
UTS2R (urotensin 2 receptor) is a protein-coding gene. Diseases associated with UTS2R include pheochromocytoma, and portal hypertension, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include urotensin II receptor activity and G-protein coupled receptor activity.

UniProtKB/Swiss-Prot: UR2R_HUMAN, Q9UKP6
Function: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a
G-protein that activate a phosphatidylinositol-calcium second messenger system

summary for UTS2R Gene:
Urotensin-II (UT) receptors are Gq/11-protein-coupled receptors that mediate complex hemodynamic effects and
influence neuromuscular physiology. UT receptors display greatest expression levels in the peripheral
vasculature, heart and kidney, although they are found in other tissues, notably the central nervous system,
at lower levels. UT receptors produce potent but variable vasoconstrictor effects in some vascular beds yet
mediate vasodilation in others and they have also been implicated in osmoregulation. The human gene encoding
the UT receptor is located on chromosome 17q25.3.

Gene Wiki entry for UTS2R (Urotensin-II receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010663.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UTS2R gene promoter:
         Bach2   SREBP-1c   MyoD   E47   Arnt   SREBP-1b   PPAR-alpha   SREBP-1a   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for UTS2R

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UTS2R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

UTS2R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UTS2R gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P080332:  view genomic region     (about GC identifiers)

Start:
80,332,153 bp from pter      End:
80,333,462 bp from pter
Size:
1,310 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UR2R_HUMAN, Q9UKP6 (See protein sequence)
Recommended Name: Urotensin-2 receptor  
Size: 389 amino acids; 42130 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2RMV8

Explore the universe of human proteins at neXtProt for UTS2R: NX_Q9UKP6

Explore proteomics data for UTS2R at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UKP6

  • UTS2R Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UTS2R Protein Expression
    REFSEQ proteins: NP_061822.1  
    ENSEMBL proteins: 
     ENSP00000323516  
    Reactome Protein details: Q9UKP6
    Human Recombinant Protein Products for UTS2R: 
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    Novus Biologicals UTS2R Lysate
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    Cloud-Clone Corp. Proteins for UTS2R 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane TAS8666380
    GO:0016021integral to membrane IEA--
    GO:0055037recycling endosome IEA--

    UTS2R for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: UT receptor 
    Urotensin receptor

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000670 Urot_II_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9UKP6

    ProtoNet protein and cluster: Q9UKP6

    1 Blocks protein domain: IPB000670 SENR orphan receptor signature

    UniProtKB/Swiss-Prot: UR2R_HUMAN, Q9UKP6
    Similarity: Belongs to the G-protein coupled receptor 1 family


    UTS2R for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UR2R_HUMAN, Q9UKP6
    Function: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a
    G-protein that activate a phosphatidylinositol-calcium second messenger system

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001604urotensin II receptor activity IEA--
    GO:0004930G-protein coupled receptor activity TAS10499587
         
    UTS2R for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Uts2r):
     cardiovascular system  muscle 

    UTS2R for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Uts2rtm1Djbe for UTS2R

       inGenious Targeting Laboratory - Custom generated mouse model solutions for UTS2R 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UTS2R About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
    5GPCRs, Other
    GPCRs, Other

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for UTS2R
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    1 BioSystems Pathway for UTS2R
        GPCRs, Other

    5/8        Reactome Pathways for UTS2R (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding


    1         Kegg Pathway  (Kegg details for UTS2R):
        Neuroactive ligand-receptor interaction


    UTS2R for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UTS2R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/123 Interacting proteins for UTS2R (Q9UKP63 ENSP000003235164) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UTS2BQ765I03, ENSP000003405264I2D: score=2 STRING: ENSP00000340526
    UTS2O953993, ENSP000000546684I2D: score=1 STRING: ENSP00000054668
    ADRA1BENSP000003066624STRING: ENSP00000306662
    AVPR1AENSP000002991784STRING: ENSP00000299178
    BDKRB1ENSP000002166294STRING: ENSP00000216629
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003105negative regulation of glomerular filtration IEA--
    GO:0007165signal transduction TAS10499587
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007204elevation of cytosolic calcium ion concentration IEA--
    GO:0008015blood circulation TAS10499587

    UTS2R for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UTS2R for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for UTS2R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Urotensin II (human)Endogenous vasoactive agonist for the UT receptor[251293-28-4]
    (+-)-AC 7954 hydrochlorideNon-peptide UT receptor agonist[477313-09-0]
    SB 657510Selective urotensin-II (UT) receptor antagonist[474960-44-6]
    [Orn8]-Urotensin IIUrotensin-II (UT) receptor partial agonist[479065-85-5]
    SB 706375 High affinity, non-peptide UT receptor antagonist [733734-61-7]

    1 HMDB Compound for UTS2R    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    10/18 IUPHAR Ligands for UTS2R (UT receptor) (see all 18)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [Pen5]-U (4-11) (human)
    AgonistFull agonist9.712238917
    [125I]U-II (human)
    AgonistFull agonist9.4 - 9.6210499587 11015293
    U-II-(4-11) (human)
    AgonistFull agonist9.612238917
    urotensin-related peptide
    NoneNone9.611015293
    [Bz-Phe6]U-II (human)
    AgonistFull agonist9.112495432
    urotensin-II
    AgonistFull agonist8.615852036 11976263 12238917
    urotensin-II
    AgonistFull agonist8.515852036
    urotensin-II
    AgonistFull agonist8.515852036
    4-Cl-cinnamoyl-c[DCys-4Pal-DTrp-Orn-Val-Cys]-His-amide
    AntagonistInverse agonist8.412535707
    urantide
    AntagonistAntagonist8.314645137

    3 Novoseek inferred chemical compound relationships for UTS2R gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    palosuran 95.2 6 19843053 (2), 16952491 (2), 15146030 (1), 19625629 (1)
    calcium 19.5 7 12503613 (2), 10499587 (1), 17537987 (1), 10581185 (1)
    glucose 0 4 19843053 (1), 16597476 (1), 15476949 (1)

    Search CenterWatch for drugs/clinical trials and news about UTS2R / UR2R

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UTS2R gene: 
    NM_018949.1  

    Unigene Cluster for UTS2R:

    Urotensin 2 receptor
    Hs.192720  [show with all ESTs]
    Unigene Representative Sequence: BC136490
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000313135(uc010wvl.2)
    miRNA
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    Additional mRNA sequence: BC136490.1 

    1 DOTS entry:

    DT.437824 

    7 AceView cDNA sequences:

    NM_018949 BF513269 AI263529 BF732711 BF733007 AA933596 AA992531 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UTS2R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGCTGGTGC
    UTS2R Expression
    About this image


    See UTS2R Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UTS2R

    SOURCE GeneReport for Unigene cluster: Hs.192720

    UniProtKB/Swiss-Prot: UR2R_HUMAN, Q9UKP6
    Tissue specificity: Most abundant expression in the heart and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including UTS2R: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Hypertension in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTS2R

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for UTS2R gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uts2r1 , 5 urotensin 2 receptor1, 5 79.51(n)1
    79.51(a)1
      11 (85.02 cM)5
    2173691  NM_145440.11  NP_663415.11 
     1211602715 
    chicken
    (Gallus gallus)
    Aves UTS2R1 urotensin 2 receptor 66.39(n)
    58.86(a)
      427800  XM_425371.1  XP_425371.1 
    lizard
    (Anolis carolinensis)
    Reptilia UTS2R6
    Uncharacterized protein
    55(a)
    1 ↔ 1
    2(109822546-109823670)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5591331 urotensin-2 receptor-like 62.72(n)
    58.66(a)
      559133  XM_682448.5  XP_687540.1 


    ENSEMBL Gene Tree for UTS2R (if available)
    TreeFam Gene Tree for UTS2R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UTS2R gene
    6 SIMAP similar genes for UTS2R using alignment to 1 protein entry:     UR2R_HUMAN:
    SSTR5    SSTR1    SSTR2    SSTR4    GALR2    NPBWR1

    UTS2R for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/130 SNPs in UTS2R are shown (see all 130)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357684
    A breast cancer sample4--see VAR_0357682 S R mis40--------
    rs1153839411,2
    F--80330256(+) CAAGGG/CGGTGA 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1143552151,2
    F--80330268(+) GGTCCC/TCTGGA 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1149161511,2
    F--80330295(+) CTGCTC/GGGCCT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1858285971,2
    C--80330411(+) ATGAGC/TGTTCG 1 -- us2k10--------
    rs1902008201,2
    --80330477(+) AGCCCA/CCCACC 1 -- us2k10--------
    rs1830242471,2
    --80330579(+) AGCTGC/TTTCCA 1 -- us2k10--------
    rs1874248831,2
    --80330620(+) TCGCAC/TGCTTG 1 -- us2k10--------
    rs116504691,2
    C,F,A,H--80330676(+) agagtA/Ggaatt 1 -- us2k121Minor allele frequency- G:0.23NS EA NA WA CSA 2097
    rs116580521,2
    C,F,H--80330684(+) attgcC/Tgggtg 1 -- us2k110Minor allele frequency- T:0.19NA WA CSA EA 374

    HapMap Linkage Disequilibrium report for UTS2R (80332153 - 80333462 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for UTS2R (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv909223CNV Loss21882294
    nsv909220CNV Loss21882294
    dgv3354n71CNV Loss21882294
    dgv3357n71CNV Loss21882294
    dgv3353n71CNV Loss21882294
    nsv909134CNV Loss21882294
    dgv3356n71CNV Loss21882294
    dgv3341n71CNV Loss21882294
    dgv3332n71CNV Loss21882294
    dgv3359n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600896    OMIM disorders: --

    13 diseases for UTS2R:    About MalaCards
    pheochromocytoma    portal hypertension    rhabdomyosarcoma    hypoxia
    diabetes mellitus    insulin resistance    hypertension    atherosclerosis
    prostate cancer    endotheliitis    prostatitis    adenocarcinoma
    neuronitis


    UTS2R for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for UTS2R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    coronary atheroma 64 1 11282300 (1)
    rhabdomyosarcoma 49.4 2 17537987 (1), 15210573 (1)
    effects cardiovascular 48.5 1 11725162 (1)
    pheochromocytoma 34.4 16 16178439 (6), 17102097 (3), 17686550 (1)
    diabetic nephropathies 13.7 2 16952491 (1), 15492948 (1)
    heart diseases 12.7 2 19258379 (1)
    cardiovascular diseases 1.66 1 15763543 (1)
    renal disease 0 1 16952491 (1)

    Genetic Association Database (GAD): UTS2R
    Human Genome Epidemiology (HuGE) Navigator: UTS2R (2 documents)

    Export disorders for UTS2R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UTS2R gene, integrated from 9 sources (see all 94):
    (articles sorted by number of sources associating them with UTS2R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. (PubMed id 10499587)1, 2, 3, 9 Ames R.S....Douglas S.A. (1999)
    2. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. (PubMed id 8666380)1, 3, 9 Marchese A.... Docherty J.M. (1995)
    3. Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose toler ance. (PubMed id 16597476)1, 4, 9 Ong K.L....Cheung B.M. (2006)
    4. Identification of urotensin II-related peptide as the urotensin II- immunoreactive molecule in the rat brain. (PubMed id 14550283)1, 2, 9 Sugo T.... Fujino M. (2003)
    5. Immunolocalization of urotensin II and its receptor in human adrenal tumors and attached non-neoplastic adrenal tissues. (PubMed id 17686550)1, 9 Morimoto R....Takahashi K. (2008)
    6. Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese. (PubMed id 15476949)1, 9 Suzuki S....Oka Y. (2004)
    7. Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14. (PubMed id 10581185)1, 9 Liu Q....Caskey C.T. (1999)
    8. Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta. (PubMed id 15306183)1, 9 Bousette N....Giaid A. (2004)
    9. Increased expression of urotensin II and GPR14 in pat ients with cirrhosis and portal hypertension. (PubMed id 20428787)1, 9 Liu D....Wang Y. (2010)
    10. Ligands and signaling of the G-protein-coupled receptor GPR14, expressed in human kidney cells. (PubMed id 17595527)1, 9 Lehner U....Sindic A. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2837 HGNC: 4468 AceView: UTS2R Ensembl:ENSG00000181408 euGenes: HUgn2837
    ECgene: UTS2R Kegg: 2837 H-InvDB: UTS2R

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UTS2R Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UTS2R gene:
    Search GeneIP for patents involving UTS2R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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