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Aliases for UTS2R Gene

Aliases for UTS2R Gene

  • Urotensin 2 Receptor 2 3 5
  • G-Protein Coupled Receptor 14 3 4
  • Urotensin II Receptor 3 4
  • UR-II-R 3 4
  • UR-2-R 3 4
  • GPR14 3 4
  • G Protein-Coupled Receptor 14 2
  • Urotensin-2 Receptor 3
  • UTR2 3
  • UTR 3

External Ids for UTS2R Gene

Previous HGNC Symbols for UTS2R Gene

  • GPR14

Previous GeneCards Identifiers for UTS2R Gene

  • GC17P077925
  • GC17P080332
  • GC17P075730

Summaries for UTS2R Gene

GeneCards Summary for UTS2R Gene

UTS2R (Urotensin 2 Receptor) is a Protein Coding gene. Diseases associated with UTS2R include Pheochromocytoma and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Peptide ligand-binding receptors and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity and urotensin II receptor activity.

UniProtKB/Swiss-Prot for UTS2R Gene

  • High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for UTS2R Gene

  • The urotensin-II (UT) receptor is a Gq/11-protein-coupled receptor that mediates complex hemodynamic effects and influences neuromuscular physiology. The UT receptor displays greatest expression levels in the peripheral vasculature, heart and kidney.

Gene Wiki entry for UTS2R Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTS2R Gene

Genomics for UTS2R Gene

Regulatory Elements for UTS2R Gene

Enhancers for UTS2R Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G082414 1.3 Ensembl ENCODE 34.9 +40.5 40485 1.2 AGO1 ZFP64 ARID4B SIN3A ZNF2 SLC30A9 ZNF766 ZNF143 ZNF207 SP3 UTS2R TEX19 SECTM1 NARF CSNK1D ENSG00000201239 PIR41898
GH17G082398 1.1 Ensembl ENCODE 19.2 +25.8 25809 2.7 CTCF KLF1 SIN3A KLF17 MAX ZIC2 ZBTB40 POLR2A EED RELB UTS2R SECTM1 OGFOD3 TEX19 CSNK1D C17orf62 WDR45B HEXDC GC17M082397 LOC102723806
GH17G082343 1.6 Ensembl ENCODE dbSUPER 10.1 -28.7 -28704 3.6 PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B DMAP1 SLC30A9 ZNF766 CBX5 TEX19 UTS2R LOC105376790 DCXR SECTM1
GH17G082417 1 ENCODE 11.6 +44.9 44890 2.7 ARNT CREB3L1 ARID4B SIN3A ZNF143 ZNF207 SP3 CEBPZ SP5 ZHX2 HEXDC OGFOD3 C17orf62 ENSG00000262049 TEX19 UTS2R NARF SECTM1 ENSG00000262663 CSNK1D
GH17G082291 2.1 FANTOM5 Ensembl ENCODE dbSUPER 5 -75.6 -75597 14.7 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 TEX19 CSNK1D SLC16A3 SECTM1 CCDC57 HGS ACTG1 ENSG00000262877 ENSG00000262049 ARHGDIA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UTS2R on UCSC Golden Path with GeneCards custom track

Genomic Location for UTS2R Gene

Chromosome:
17
Start:
82,374,230 bp from pter
End:
82,375,586 bp from pter
Size:
1,357 bases
Orientation:
Plus strand

Genomic View for UTS2R Gene

Genes around UTS2R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTS2R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTS2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTS2R Gene

Proteins for UTS2R Gene

  • Protein details for UTS2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKP6-UR2R_HUMAN
    Recommended name:
    Urotensin-2 receptor
    Protein Accession:
    Q9UKP6
    Secondary Accessions:
    • B2RMV8

    Protein attributes for UTS2R Gene

    Size:
    389 amino acids
    Molecular mass:
    42130 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UTS2R Gene

Post-translational modifications for UTS2R Gene

  • Glycosylation at Asn29 and posLast=3333
  • Modification sites at PhosphoSitePlus

Other Protein References for UTS2R Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UTS2R Gene

Domains & Families for UTS2R Gene

Gene Families for UTS2R Gene

IUPHAR :

Protein Domains for UTS2R Gene

Suggested Antigen Peptide Sequences for UTS2R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKP6

UniProtKB/Swiss-Prot:

UR2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with UTS2R: view

Function for UTS2R Gene

Molecular function for UTS2R Gene

UniProtKB/Swiss-Prot Function:
High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.

Gene Ontology (GO) - Molecular Function for UTS2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001604 urotensin II receptor activity IBA --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 10499587
genes like me logo Genes that share ontologies with UTS2R: view
genes like me logo Genes that share phenotypes with UTS2R: view

Animal Models for UTS2R Gene

MGI Knock Outs for UTS2R:

Animal Model Products

  • Taconic Biosciences Mouse Models for UTS2R

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UTS2R

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for UTS2R Gene

Localization for UTS2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTS2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTS2R gene
Compartment Confidence
plasma membrane 5
endosome 2

Gene Ontology (GO) - Cellular Components for UTS2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane TAS 8666380
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UTS2R: view

Pathways & Interactions for UTS2R Gene

genes like me logo Genes that share pathways with UTS2R: view

Gene Ontology (GO) - Biological Process for UTS2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003105 negative regulation of glomerular filtration IEA --
GO:0007165 signal transduction TAS 10499587
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
genes like me logo Genes that share ontologies with UTS2R: view

No data available for SIGNOR curated interactions for UTS2R Gene

Drugs & Compounds for UTS2R Gene

(28) Drugs for UTS2R Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palosuran Pharma Antagonist Urotensin-II receptor antagonist 0
GSK 1562590 hydrochloride Pharma High affinity, selective urotensin II (UT) receptor antagonist 0
SB 657510 Pharma Selective urotensin-II (UT) receptor antagonist 0
SB 706375 Pharma High affinity, non-peptide UT receptor antagonist 0
Urotensin II (human) Pharma Endogenous vasoactive agonist for the UT receptor 0

(1) Additional Compounds for UTS2R Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-AC 7954 hydrochloride
477313-09-0

(5) Tocris Compounds for UTS2R Gene

Compound Action Cas Number
(+-)-AC 7954 hydrochloride Non-peptide UT receptor agonist 477313-09-0
GSK 1562590 hydrochloride High affinity, selective urotensin II (UT) receptor antagonist 1003878-07-6
SB 657510 Selective urotensin-II (UT) receptor antagonist 474960-44-6
SB 706375 High affinity, non-peptide UT receptor antagonist 733734-61-7
Urotensin II (human) Endogenous vasoactive agonist for the UT receptor 251293-28-4

(11) ApexBio Compounds for UTS2R Gene

Compound Action Cas Number
(±)-AC 7954 hydrochloride 477313-09-0
[Orn5]-URP 782485-03-4
[Orn8]-Urotensin II 479065-85-5
GSK 1562590 hydrochloride 1003878-07-6
Palosuran Urotensin-II receptor antagonist 540769-28-6
SB 611812 345892-71-9
SB 657510 474960-44-6
SB 706375 733734-61-7
UFP 803 879497-82-2
Urotensin II (human) 251293-28-4
Urotensin II-related peptide 342878-90-4
genes like me logo Genes that share compounds with UTS2R: view

Drug Products

Transcripts for UTS2R Gene

mRNA/cDNA for UTS2R Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UTS2R Gene

Urotensin 2 receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UTS2R

Alternative Splicing Database (ASD) splice patterns (SP) for UTS2R Gene

No ASD Table

Relevant External Links for UTS2R Gene

GeneLoc Exon Structure for
UTS2R
ECgene alternative splicing isoforms for
UTS2R

Expression for UTS2R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UTS2R Gene

mRNA differential expression in normal tissues according to GTEx for UTS2R Gene

This gene is overexpressed in Testis (x14.5), Thyroid (x4.5), and Heart - Atrial Appendage (x4.1).

Protein differential expression in normal tissues from HIPED for UTS2R Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UTS2R Gene



Protein tissue co-expression partners for UTS2R Gene

NURSA nuclear receptor signaling pathways regulating expression of UTS2R Gene:

UTS2R

SOURCE GeneReport for Unigene cluster for UTS2R Gene:

Hs.192720

mRNA Expression by UniProt/SwissProt for UTS2R Gene:

Q9UKP6-UR2R_HUMAN
Tissue specificity: Most abundant expression in the heart and pancreas.

Evidence on tissue expression from TISSUES for UTS2R Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with UTS2R: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for UTS2R Gene

Orthologs for UTS2R Gene

This gene was present in the common ancestor of animals.

Orthologs for UTS2R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTS2R 34 35
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia UTS2R 34 35
  • 82.26 (n)
cow
(Bos Taurus)
Mammalia UTS2R 34 35
  • 80.6 (n)
mouse
(Mus musculus)
Mammalia Uts2r 34 16 35
  • 78.71 (n)
rat
(Rattus norvegicus)
Mammalia Uts2r 34
  • 78.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UTS2R 35
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UTS2R 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves UTS2R 34 35
  • 65.12 (n)
lizard
(Anolis carolinensis)
Reptilia UTS2R 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485936 34
  • 67.55 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC559133 34
  • 59.96 (n)
UTS2R 35
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea npr-16 35
  • 18 (a)
OneToOne
Species where no ortholog for UTS2R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTS2R Gene

ENSEMBL:
Gene Tree for UTS2R (if available)
TreeFam:
Gene Tree for UTS2R (if available)

Paralogs for UTS2R Gene

(6) SIMAP similar genes for UTS2R Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UTS2R: view

No data available for Paralogs for UTS2R Gene

Variants for UTS2R Gene

Sequence variations from dbSNP and Humsavar for UTS2R Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs770047242 A breast cancer sample 82,374,762(+) AGCAG(C/G/T)GAGCG reference, synonymous-codon, missense
rs1000568351 -- 82,373,974(+) GTTCC(A/G)GCTTT upstream-variant-2KB
rs1001118765 -- 82,373,701(+) TTCCC(C/T)GTATG upstream-variant-2KB
rs1002372071 -- 82,374,147(+) TGGAG(A/G)GCACT upstream-variant-2KB
rs1002739274 -- 82,374,024(+) AGTGA(-/G)GGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UTS2R Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv2760445 CNV gain 21179565
esv2762577 CNV gain+loss 21179565
esv3641423 CNV gain 21293372
nsv1059334 CNV gain 25217958
nsv1067194 CNV gain 25217958
nsv428351 CNV gain 18775914
nsv469561 CNV loss 16826518
nsv833572 CNV loss 17160897
nsv833573 CNV loss 17160897
nsv952394 CNV deletion 24416366

Variation tolerance for UTS2R Gene

Gene Damage Index Score: 2.20; 39.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTS2R Gene

Human Gene Mutation Database (HGMD)
UTS2R
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTS2R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTS2R Gene

Disorders for UTS2R Gene

MalaCards: The human disease database

(2) MalaCards diseases for UTS2R Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pheochromocytoma
  • pheochromocytoma, modifier of
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search UTS2R in MalaCards View complete list of genes associated with diseases

Relevant External Links for UTS2R

Genetic Association Database (GAD)
UTS2R
Human Genome Epidemiology (HuGE) Navigator
UTS2R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTS2R
genes like me logo Genes that share disorders with UTS2R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UTS2R Gene

Publications for UTS2R Gene

  1. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. (PMID: 10499587) Ames R.S. … Douglas S.A. (Nature 1999) 2 3 4 22 64
  2. Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance. (PMID: 16597476) Ong K.L. … Cheung B.M. (Peptides 2006) 3 22 46 64
  3. Identification of urotensin II-related peptide as the urotensin II- immunoreactive molecule in the rat brain. (PMID: 14550283) Sugo T. … Fujino M. (Biochem. Biophys. Res. Commun. 2003) 3 4 22 64
  4. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. (PMID: 8666380) Marchese A. … Docherty J.M. (Genomics 1995) 2 3 22 64
  5. Increased expression of urotensin II and GPR14 in patients with cirrhosis and portal hypertension. (PMID: 20428787) Liu D. … Wang Y. (Int. J. Mol. Med. 2010) 3 22 64

Products for UTS2R Gene

  • Addgene plasmids for UTS2R

Sources for UTS2R Gene

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