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Aliases for UTS2B Gene

Aliases for UTS2B Gene

  • Urotensin 2B 2 3 5
  • Urotensin-2 Domain-Containing Protein 3 4
  • Urotensin 2 Domain Containing 2 3
  • Urotensin II-Related Peptide 3 4
  • Urotensin IIB 3 4
  • Prepro-URP 2 3

External Ids for UTS2B Gene

Previous HGNC Symbols for UTS2B Gene

  • UTS2D

Previous GeneCards Identifiers for UTS2B Gene

  • GC03M190985

Summaries for UTS2B Gene

GeneCards Summary for UTS2B Gene

UTS2B (Urotensin 2B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include hormone activity and G-protein coupled receptor binding.

UniProtKB/Swiss-Prot for UTS2B Gene

  • Potent vasoconstrictor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTS2B Gene

Genomics for UTS2B Gene

Regulatory Elements for UTS2B Gene

Promoters for UTS2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UTS2B on UCSC Golden Path with GeneCards custom track

Genomic Location for UTS2B Gene

Chromosome:
3
Start:
191,267,155 bp from pter
End:
191,330,536 bp from pter
Size:
63,382 bases
Orientation:
Minus strand

Genomic View for UTS2B Gene

Genes around UTS2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTS2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTS2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTS2B Gene

Proteins for UTS2B Gene

  • Protein details for UTS2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q765I0-UTS2B_HUMAN
    Recommended name:
    Urotensin-2B
    Protein Accession:
    Q765I0
    Secondary Accessions:
    • B3KQY8
    • D3DNW1
    • Q2M1Z2

    Protein attributes for UTS2B Gene

    Size:
    119 amino acids
    Molecular mass:
    13749 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UTS2B Gene

Proteomics data for UTS2B Gene at MOPED

Post-translational modifications for UTS2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UTS2B Gene

No data available for DME Specific Peptides for UTS2B Gene

Domains & Families for UTS2B Gene

Gene Families for UTS2B Gene

Protein Domains for UTS2B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for UTS2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q765I0

UniProtKB/Swiss-Prot:

UTS2B_HUMAN :
  • Belongs to the urotensin-2 family.
Family:
  • Belongs to the urotensin-2 family.
genes like me logo Genes that share domains with UTS2B: view

Function for UTS2B Gene

Molecular function for UTS2B Gene

UniProtKB/Swiss-Prot Function:
Potent vasoconstrictor.

Phenotypes for UTS2B Gene

genes like me logo Genes that share phenotypes with UTS2B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UTS2B Gene

Localization for UTS2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTS2B Gene

Secreted.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for UTS2B Gene

Pathways & Interactions for UTS2B Gene

genes like me logo Genes that share pathways with UTS2B: view

Gene Ontology (GO) - Biological Process for UTS2B Gene

None

No data available for SIGNOR curated interactions for UTS2B Gene

Drugs & Compounds for UTS2B Gene

No Compound Related Data Available

Transcripts for UTS2B Gene

Unigene Clusters for UTS2B Gene

Urotensin 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UTS2B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: -
SP2: - - -
SP3:
SP4: - -

Relevant External Links for UTS2B Gene

GeneLoc Exon Structure for
UTS2B
ECgene alternative splicing isoforms for
UTS2B

Expression for UTS2B Gene

mRNA expression in normal human tissues for UTS2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UTS2B Gene

This gene is overexpressed in Testis (x7.0) and Brain - Amygdala (x4.8).

Protein differential expression in normal tissues from HIPED for UTS2B Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UTS2B Gene



SOURCE GeneReport for Unigene cluster for UTS2B Gene Hs.518492

genes like me logo Genes that share expression patterns with UTS2B: view

Protein tissue co-expression partners for UTS2B Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UTS2B Gene

Orthologs for UTS2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for UTS2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTS2D 36
  • 97 (a)
OneToOne
UTS2D 35
  • 98.6 (n)
  • 96.64 (a)
cow
(Bos Taurus)
Mammalia UTS2B 36
  • 70 (a)
OneToOne
UTS2B 35
  • 81.51 (n)
  • 73.95 (a)
dog
(Canis familiaris)
Mammalia UTS2B 35
  • 82.35 (n)
  • 74.79 (a)
UTS2B 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uts2b 36
  • 50 (a)
OneToOne
Uts2b 16
Uts2b 35
  • 69.05 (n)
  • 50.89 (a)
rat
(Rattus norvegicus)
Mammalia Uts2b 35
  • 72.08 (n)
  • 55.56 (a)
chicken
(Gallus gallus)
Aves UTS2D 35
  • 58.48 (n)
  • 42.11 (a)
UTS2D 36
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uts2b 35
  • 59.32 (n)
  • 52.54 (a)
Species with no ortholog for UTS2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UTS2B Gene

ENSEMBL:
Gene Tree for UTS2B (if available)
TreeFam:
Gene Tree for UTS2B (if available)

Paralogs for UTS2B Gene

No data available for Paralogs for UTS2B Gene

Variants for UTS2B Gene

Sequence variations from dbSNP and Humsavar for UTS2B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs6788319 - 191,282,128(+) AAAAA(A/C)TCAAC reference, missense
rs150503 -- 191,303,187(-) ttata(C/T)agtat intron-variant
rs499212 -- 191,304,504(+) tcgtg(C/G)tattt utr-variant-5-prime
rs297368 -- 191,293,969(+) CGGGC(A/G)TGGTG intron-variant
rs1369280 -- 191,293,268(+) tagaa(C/T)gaatt intron-variant

Variation tolerance for UTS2B Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 50.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTS2B Gene

HapMap Linkage Disequilibrium report
UTS2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UTS2B Gene

Disorders for UTS2B Gene

Relevant External Links for UTS2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTS2B

No disorders were found for UTS2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTS2B Gene

Publications for UTS2B Gene

  1. Identification of urotensin II-related peptide as the urotensin II- immunoreactive molecule in the rat brain. (PMID: 14550283) Sugo T. … Fujino M. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23 67
  2. Urotensin-II system in genetic control of blood pressure and renal function. (PMID: 24391740) Debiec R. … Tomaszewski M. (PLoS ONE 2013) 3
  3. Human U2Ba8^ protein binding to snRNA stemloops. (PMID: 21684671) Williams S.G. … Hall K.B. (Biophys. Chem. 2011) 3
  4. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 3
  5. The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation. (PMID: 20192922) Jarry M. … Gandolfo P. (Biochem. J. 2010) 23

Products for UTS2B Gene

Sources for UTS2B Gene

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