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Aliases for UTS2B Gene

Aliases for UTS2B Gene

  • Urotensin 2B 2 3 5
  • Urotensin-2 Domain-Containing Protein 3 4
  • Urotensin 2 Domain Containing 2 3
  • Urotensin II-Related Peptide 3 4
  • Urotensin IIB 3 4
  • Prepro-URP 2 3
  • UTS2D 3 4
  • U-IIB 3 4
  • UIIB 3 4
  • URP 3 4
  • Urotensin-2B 3
  • U2B 3

External Ids for UTS2B Gene

Previous HGNC Symbols for UTS2B Gene

  • UTS2D

Previous GeneCards Identifiers for UTS2B Gene

  • GC03M190985

Summaries for UTS2B Gene

GeneCards Summary for UTS2B Gene

UTS2B (Urotensin 2B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and RET signaling. GO annotations related to this gene include hormone activity and G-protein coupled receptor binding.

UniProtKB/Swiss-Prot for UTS2B Gene

  • Potent vasoconstrictor.

Additional gene information for UTS2B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTS2B Gene

Genomics for UTS2B Gene

Regulatory Elements for UTS2B Gene

Enhancers for UTS2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H191355 1.3 Ensembl ENCODE dbSUPER 19.9 -26.5 -26455 2.6 INSM2 SIN3A RAD21 RELA HIC1 ATF7 ETV6 RUNX3 NR2F1 TRIM22 CCDC50 UTS2B GC03P191372
GH03H191356 1.2 Ensembl ENCODE dbSUPER 17.6 -25.0 -24986 0.2 NR2F1 TRIM22 JUNB DPF2 BATF RELA BCL11A IKZF1 NBN ETV6 UTS2B CCDC50 GC03P191372
GH03H191375 1.3 Ensembl ENCODE dbSUPER 10.6 -46.3 -46314 1.8 KLF1 JUN INSM2 FEZF1 ZFHX2 ZNF316 ZNF600 PRDM10 NFE2 FOS CCDC50 UTS2B GC03P191372 GC03P191395
GH03H191364 0.7 dbSUPER 19.5 -38.2 -38237 8.9 JUN MAFG DPF2 ZBTB40 ZNF316 POU5F1 HMBOX1 NFE2 RCOR1 MAFK CCDC50 UTS2B OSTN GC03P191372
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UTS2B on UCSC Golden Path with GeneCards custom track

Promoters for UTS2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000163850 236 2601 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Locations for UTS2B Gene

Genomic Locations for UTS2B Gene
63,382 bases
Minus strand

Genomic View for UTS2B Gene

Genes around UTS2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTS2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTS2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTS2B Gene

Proteins for UTS2B Gene

  • Protein details for UTS2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KQY8
    • D3DNW1
    • Q2M1Z2

    Protein attributes for UTS2B Gene

    119 amino acids
    Molecular mass:
    13749 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UTS2B Gene

Post-translational modifications for UTS2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for UTS2B Gene

Domains & Families for UTS2B Gene

Gene Families for UTS2B Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for UTS2B Gene


Suggested Antigen Peptide Sequences for UTS2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the urotensin-2 family.
  • Belongs to the urotensin-2 family.
genes like me logo Genes that share domains with UTS2B: view

Function for UTS2B Gene

Molecular function for UTS2B Gene

UniProtKB/Swiss-Prot Function:
Potent vasoconstrictor.

Phenotypes From GWAS Catalog for UTS2B Gene

Gene Ontology (GO) - Molecular Function for UTS2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IEA --
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with UTS2B: view

Phenotypes for UTS2B Gene

genes like me logo Genes that share phenotypes with UTS2B: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UTS2B Gene

Localization for UTS2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTS2B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTS2B gene
Compartment Confidence
extracellular 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UTS2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with UTS2B: view

Pathways & Interactions for UTS2B Gene

genes like me logo Genes that share pathways with UTS2B: view

Gene Ontology (GO) - Biological Process for UTS2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008217 regulation of blood pressure IEA --
GO:0097746 regulation of blood vessel diameter IEA --
genes like me logo Genes that share ontologies with UTS2B: view

No data available for SIGNOR curated interactions for UTS2B Gene

Drugs & Compounds for UTS2B Gene

No Compound Related Data Available

Transcripts for UTS2B Gene

Unigene Clusters for UTS2B Gene

Urotensin 2B:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTS2B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: -
SP2: - - -
SP4: - -

Relevant External Links for UTS2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UTS2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UTS2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UTS2B Gene

This gene is overexpressed in Testis (x7.0) and Brain - Amygdala (x4.8).

Protein differential expression in normal tissues from HIPED for UTS2B Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UTS2B Gene

Protein tissue co-expression partners for UTS2B Gene

NURSA nuclear receptor signaling pathways regulating expression of UTS2B Gene:


SOURCE GeneReport for Unigene cluster for UTS2B Gene:


Evidence on tissue expression from TISSUES for UTS2B Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with UTS2B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UTS2B Gene

Orthologs for UTS2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for UTS2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UTS2D 33 34
  • 98.6 (n)
(Canis familiaris)
Mammalia UTS2B 33 34
  • 82.35 (n)
(Bos Taurus)
Mammalia UTS2B 33 34
  • 81.51 (n)
(Rattus norvegicus)
Mammalia Uts2b 33
  • 72.08 (n)
(Mus musculus)
Mammalia Uts2b 33 16 34
  • 69.05 (n)
(Gallus gallus)
Aves UTS2D 33 34
  • 58.48 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia uts2b 33
  • 59.32 (n)
Species where no ortholog for UTS2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UTS2B Gene

Gene Tree for UTS2B (if available)
Gene Tree for UTS2B (if available)

Paralogs for UTS2B Gene

No data available for Paralogs for UTS2B Gene

Variants for UTS2B Gene

Sequence variations from dbSNP and Humsavar for UTS2B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs9847278 Benign 191,329,743(+) GGGAG(A/G)GCGCG intron-variant, upstream-variant-2KB
rs1000041398 -- 191,295,220(+) CAATC(C/T)CTTTG intron-variant
rs1000068247 -- 191,271,913(+) GTGGT(A/C)GGAAT intron-variant
rs1000071753 -- 191,312,853(+) CTAAC(A/C)CTTTA intron-variant
rs1000091811 -- 191,295,503(+) TCTTT(C/T)ATTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UTS2B Gene

Variant ID Type Subtype PubMed ID
nsv998208 CNV gain 25217958
nsv997716 CNV loss 25217958
nsv509873 OTHER sequence alteration 20534489
nsv428428 CNV gain 18775914
nsv4169 CNV deletion 18451855
nsv10370 CNV loss 18304495
nsv10369 CNV loss 18304495
nsv1012488 CNV loss 25217958
esv7437 CNV gain 19470904
esv3599103 CNV gain 21293372
esv3599102 CNV loss 21293372
esv3599101 CNV loss 21293372
esv3599099 CNV gain 21293372
esv3599098 CNV loss 21293372
esv3599096 CNV gain 21293372
esv3599095 CNV loss 21293372
esv3599094 CNV loss 21293372
esv3599090 CNV gain 21293372
esv3599089 CNV loss 21293372
esv3404133 CNV insertion 20981092
esv3365700 CNV insertion 20981092
esv3308454 CNV mobile element insertion 20981092
esv3304195 CNV mobile element insertion 20981092
esv2763330 CNV loss 21179565
esv2759209 CNV gain+loss 17122850
esv26911 CNV loss 19812545
esv2668071 CNV deletion 23128226

Variation tolerance for UTS2B Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 50.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTS2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTS2B Gene

Disorders for UTS2B Gene

Relevant External Links for UTS2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UTS2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTS2B Gene

Publications for UTS2B Gene

  1. Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain. (PMID: 14550283) Sugo T … Fujino M (Biochemical and biophysical research communications 2003) 2 3 4 22 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Urotensin-II system in genetic control of blood pressure and renal function. (PMID: 24391740) Debiec R … Tomaszewski M (PloS one 2013) 3 60
  4. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney SJ … AddNeuroMed Consortium (Molecular psychiatry 2011) 3 60
  5. Human U2B″ protein binding to snRNA stemloops. (PMID: 21684671) Williams SG … Hall KB (Biophysical chemistry 2011) 3 60

Products for UTS2B Gene

Sources for UTS2B Gene

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