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UTS2B Gene

protein-coding   GIFtS: 39
GCID: GC03M190985

Urotensin 2B

(Previous name: urotensin 2 domain containing)
(Previous symbol: UTS2D)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Urotensin 2B1 2     Urotensin-2 Domain-Containing Protein2 3
UTS2D1 2 3     U-IIB2 3
Urotensin 2 Domain Containing1 2     UIIB2 3
prepro-URP1 2     URP2 3
Urotensin II-Related Peptide2 3     U2B2
Urotensin IIB2 3     urotensin-2B2

External Ids:    HGNC: 308941   Entrez Gene: 2573132   Ensembl: ENSG000001889587   UniProtKB: Q765I03   

Export aliases for UTS2B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UTS2B Gene:
UTS2B (urotensin 2B) is a protein-coding gene. Diseases associated with UTS2B include portal hypertension, and gestational diabetes. GO annotations related to this gene include hormone activity and G-protein coupled receptor binding.

UniProtKB/Swiss-Prot: UTS2B_HUMAN, Q765I0
Function: Potent vasoconstrictor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for UTS2B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUTS2B promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UTS2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28   Ensembl cytogenetic band:  3q28   HGNC cytogenetic band: 3q28

UTS2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UTS2B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M190985:  view genomic region     (about GC identifiers)

Start:
190,984,944 bp from pter      End:
191,048,325 bp from pter
Size:
63,382 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UTS2B_HUMAN, Q765I0 (See protein sequence)
Recommended Name: Urotensin-2B precursor  
Size: 119 amino acids; 13749 Da
Secondary accessions: B3KQY8 D3DNW1 Q2M1Z2

Explore the universe of human proteins at neXtProt for UTS2B: NX_Q765I0

Explore proteomics data for UTS2B at MOPED


See UTS2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_937795.2  
ENSEMBL proteins: 
 ENSP00000340526   ENSP00000398540   ENSP00000415628   ENSP00000398761   ENSP00000404406  
 ENSP00000401028  
Reactome Protein details: Q765I0

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands

1 InterPro protein domain:
 IPR001483 Urotensin_II

Graphical View of Domain Structure for InterPro Entry Q765I0

ProtoNet protein and cluster: Q765I0

1 Blocks protein domain: IPB001483 Urotensin II

UniProtKB/Swiss-Prot: UTS2B_HUMAN, Q765I0
Similarity: Belongs to the urotensin-2 family


UTS2B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: UTS2B_HUMAN, Q765I0
Function: Potent vasoconstrictor (By similarity)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001664G-protein coupled receptor binding IEA--
GO:0005179hormone activity IEA--
     
UTS2B for ontologies           About GeneDecksing


Phenotypes:
     1 MGI phenotypic allele for Uts2d (no phenotypes)

UTS2B for phenotypes           About GeneDecksing

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
UTS2B_HUMAN, Q765I0: Secreted (By similarity)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--

UTS2B for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for UTS2B About    
See pathways by source

SuperPathContained pathways About
1Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90
2Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
3Gastrin-CREB signalling pathway via PKC and MAPK
Gastrin-CREB signalling pathway via PKC and MAPK0.90
G alpha (q) signalling events0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 Reactome Pathways for UTS2B
    Peptide ligand-binding receptors
G alpha (q) signalling events



UTS2B for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UTS2B
Interactions:

    Search GeneGlobe Interaction Network for UTS2B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for UTS2B (Q765I03 ENSP000003405264) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
InteractantInteraction Details
GeneCardExternal ID(s)
UTS2RQ9UKP63, ENSP000003235164I2D: score=2 STRING: ENSP00000323516
ADRA1BENSP000003066624STRING: ENSP00000306662
ADRA1DENSP000003687664STRING: ENSP00000368766
CCKENSP000003356574STRING: ENSP00000335657
EDN1ENSP000003686834STRING: ENSP00000368683
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008217regulation of blood pressure IEA--
GO:0042312regulation of vasodilation IEA--

UTS2B for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for UTS2B



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for UTS2B gene: 
NM_198152.3  

Unigene Cluster for UTS2B:

Urotensin 2B
Hs.518492  [show with all ESTs]
Unigene Representative Sequence: NM_198152
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000340524(uc003fsu.3) ENST00000440476 ENST00000446788 ENST00000427544
ENST00000425357 ENST00000463450 ENST00000432514 ENST00000490825 ENST00000464814

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Additional mRNA sequence: 

AB116021.1 AK090630.1 AY321313.1 BC112166.1 

3 DOTS entries:

DT.40112347  DT.120881781  DT.92025937 

Selected AceView cDNA sequences (see all 25):

AB116021 AK090630 BF699233 BG719868 AX746546 BG501297 BI523816 AY321313 
NM_198152 AA443532 BX108280 BF700173 AI472863 BQ001512 BQ000995 BQ021661 
N35184 BF670238 BI461754 BF666778 BF696056 N23399 BF696740 BF700805 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for UTS2B    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1:                    -                                       
SP2:                    -           -     -                     
SP3:                                                            
SP4:                                -     -                     


ECgene alternative splicing isoforms for UTS2B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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UTS2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
UTS2B Expression
About this image

UTS2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

UTS2B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.518492
    Custom PCR Arrays for UTS2B
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for UTS2B gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Uts2d5
Uts2b1
urotensin 2 domain containing5
urotensin 2B1
69.05(n)1
50.89(a)1
  16 (18.93 cM)5
2240651  NM_198166.31  NP_937809.11 
 273533225 
chicken
(Gallus gallus)
Aves UTS2D1 urotensin 2 domain containing 58.48(n)
42.11(a)
  404534  NM_206989.1  NP_996872.1 
African clawed frog
(Xenopus laevis)
Amphibia BJ084121.12   -- 80.36(n)    BJ084121.1 


ENSEMBL Gene Tree for UTS2B (if available)
TreeFam Gene Tree for UTS2B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for UTS2B (see all 1462)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1434120591,2
C--190984504(+) AAATT-/TTAA  
        
TTGAC
1 -- ds50010--------
rs1473610061,2
C--190984506(+) ATTTT-/AATT  
        
GACTA
1 -- ds50010--------
rs105749911,2
C--190984509(+) ATTTT-/A/AATT
        
GACTA
1 -- ds50011NA 2
rs124921451,2
C,F,H--190984601(+) TTTTGG/CGGTTT 1 -- ds50018Minor allele frequency- C:0.16EA NS NA CSA WA 546
rs1853918571,2
--190984635(+) ACTGTA/GTCTAA 1 -- ds50010--------
rs1898552351,2
--190984787(+) TCCCCA/TGAGTT 1 -- ds50010--------
rs2001497391,2
--190984809(+) TTCTG-/CCTTAG 1 -- ds50010--------
rs113882711,2
C--190984810(+) TCTGCT/-TTAGT 1 -- ds50011Minor allele frequency- -:0.00NA 2
rs1822492051,2
--190984901(+) AATGAA/GAAAGA 1 -- ds50010--------
rs11295861,2
C,F,O,A,H--190985047(-) TCTATT/CGTATG 1 -- ut3132Minor allele frequency- C:0.16NS MN NA EA WA 2902

HapMap Linkage Disequilibrium report for UTS2B (190984944 - 191048325 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for UTS2B: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing UTS2B
DNA2.0 Custom Variant and Variant Library Synthesis for UTS2B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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8 diseases for UTS2B:    
About MalaCards
portal hypertension    gestational diabetes    coronary artery disease    liver disease
ischemia    diabetes mellitus    hypertension    alzheimer's disease


UTS2B for disorders           About GeneDecksing


Export disorders for UTS2B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for UTS2B gene, integrated from 10 sources (see all 28):
(articles sorted by number of sources associating them with UTS2B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of urotensin II-related peptide as the urotensin II- immunoreactive molecule in the rat brain. (PubMed id 14550283)1, 2, 3, 9 Sugo T.... Fujino M. (Biochem. Biophys. Res. Commun. 2003)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. (PubMed id 23562540)1 Cruchaga C....Goate A.M. (Neuron 2013)
  4. Human U2Ba8^ protein binding to snRNA stemloops. (PubMed id 21684671)1 Williams S.G. and Hall K.B. (Biophys. Chem. 2011)
  5. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)1 Furney S.J.... . (Mol. Psychiatry 2011)
  6. Urotensin II: a novel vasoactive mediator linked to chronic liver disease and portal hypertension. (PubMed id 17919235)1 Kemp W....Roberts S. (Liver Int. 2007)
  7. Urotensin-II in the lung: a matter for vascular remodelling and pulmonary hypertension? (PubMed id 18000598)1 Djordjevic T. and GAPrlach A. (Thromb. Haemost. 2007)
  8. Human urotensin II as a link between hypertension and coronary artery disease. (PubMed id 16940699)1 Watanabe T....Katagiri T. (Hypertens. Res. 2006)
  9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  10. [Role of urotensin II gene in the genetic susceptibility to gestational diabetes mellitus in northern Chinese women]. (PubMed id 17327028)1 Tan Y.J....Yang H.X. (Zhonghua Fu Chan Ke Za Zhi 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 257313 HGNC: 30894 AceView: URP Ensembl:ENSG00000188958 euGenes: HUgn257313
ECgene: UTS2B H-InvDB: UTS2B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for UTS2B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for UTS2B gene:
Search GeneIP for patents involving UTS2B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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