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Aliases for UTS2B Gene

Aliases for UTS2B Gene

  • Urotensin 2B 2 3 5
  • Urotensin-2 Domain-Containing Protein 3 4
  • Urotensin 2 Domain Containing 2 3
  • Urotensin II-Related Peptide 3 4
  • Urotensin IIB 3 4
  • Prepro-URP 2 3
  • UTS2D 3 4
  • U-IIB 3 4
  • UIIB 3 4
  • URP 3 4
  • Urotensin-2B 3
  • U2B 3

External Ids for UTS2B Gene

Previous HGNC Symbols for UTS2B Gene

  • UTS2D

Previous GeneCards Identifiers for UTS2B Gene

  • GC03M190985

Summaries for UTS2B Gene

GeneCards Summary for UTS2B Gene

UTS2B (Urotensin 2B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include hormone activity and G-protein coupled receptor binding.

UniProtKB/Swiss-Prot for UTS2B Gene

  • Potent vasoconstrictor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTS2B Gene

Genomics for UTS2B Gene

Regulatory Elements for UTS2B Gene

Enhancers for UTS2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F191355 1 Ensembl ENCODE 19.8 -26.3 -26300 2.9 MTA2 INSM2 JUNB ZEB2 RAD21 TBX21 ZNF843 ATF2 RELA HIC1 CCDC50 UTS2B GC03P191372
GH03F191236 1.3 FANTOM5 Ensembl ENCODE 11.1 +92.1 92128 3.2 SOX13 ELF3 ZNF146 ESRRA HIC1 GATA3 MAFK HOMEZ MIXL1 SOX5 CCDC50 UTS2B OSTN-AS1
GH03F191300 1.1 FANTOM5 Ensembl ENCODE 12.4 +29.6 29613 1.1 TBP CBX5 IKZF1 TBX21 SPI1 CCDC50 UTS2B OSTN-AS1
GH03F191245 1.1 Ensembl ENCODE 11.3 +84.3 84335 1.6 INSM2 BRCA1 ZNF366 ETV6 FOS NFYA CEBPB USF2 ZEB2 RAD51 CCDC50 UTS2B OSTN-AS1
GH03F191295 0.9 ENCODE 12.4 +34.2 34197 1.5 HDGF PKNOX1 TBL1XR1 YBX1 BMI1 ZBTB40 CBX5 ZNF207 ETV6 CREM CCDC50 UTS2B OSTN-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UTS2B on UCSC Golden Path with GeneCards custom track

Promoters for UTS2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001382809 136 3201 HDGF ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143

Genomic Location for UTS2B Gene

Chromosome:
3
Start:
191,267,155 bp from pter
End:
191,330,536 bp from pter
Size:
63,382 bases
Orientation:
Minus strand

Genomic View for UTS2B Gene

Genes around UTS2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTS2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTS2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTS2B Gene

Proteins for UTS2B Gene

  • Protein details for UTS2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q765I0-UTS2B_HUMAN
    Recommended name:
    Urotensin-2B
    Protein Accession:
    Q765I0
    Secondary Accessions:
    • B3KQY8
    • D3DNW1
    • Q2M1Z2

    Protein attributes for UTS2B Gene

    Size:
    119 amino acids
    Molecular mass:
    13749 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UTS2B Gene

Post-translational modifications for UTS2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for UTS2B Gene

Domains & Families for UTS2B Gene

Gene Families for UTS2B Gene

Protein Domains for UTS2B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for UTS2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q765I0

UniProtKB/Swiss-Prot:

UTS2B_HUMAN :
  • Belongs to the urotensin-2 family.
Family:
  • Belongs to the urotensin-2 family.
genes like me logo Genes that share domains with UTS2B: view

Function for UTS2B Gene

Molecular function for UTS2B Gene

UniProtKB/Swiss-Prot Function:
Potent vasoconstrictor.

Gene Ontology (GO) - Molecular Function for UTS2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IEA --
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with UTS2B: view

Phenotypes for UTS2B Gene

genes like me logo Genes that share phenotypes with UTS2B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UTS2B Gene

Localization for UTS2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTS2B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTS2B gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for UTS2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with UTS2B: view

Pathways & Interactions for UTS2B Gene

genes like me logo Genes that share pathways with UTS2B: view

Gene Ontology (GO) - Biological Process for UTS2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008217 regulation of blood pressure IEA --
GO:0042312 regulation of vasodilation IEA --
genes like me logo Genes that share ontologies with UTS2B: view

No data available for SIGNOR curated interactions for UTS2B Gene

Transcripts for UTS2B Gene

Unigene Clusters for UTS2B Gene

Urotensin 2B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTS2B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: -
SP2: - - -
SP3:
SP4: - -

Relevant External Links for UTS2B Gene

GeneLoc Exon Structure for
UTS2B
ECgene alternative splicing isoforms for
UTS2B

Expression for UTS2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UTS2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UTS2B Gene

This gene is overexpressed in Testis (x7.0) and Brain - Amygdala (x4.8).

Protein differential expression in normal tissues from HIPED for UTS2B Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UTS2B Gene



Protein tissue co-expression partners for UTS2B Gene

NURSA nuclear receptor signaling pathways regulating expression of UTS2B Gene:

UTS2B

SOURCE GeneReport for Unigene cluster for UTS2B Gene:

Hs.518492
genes like me logo Genes that share expression patterns with UTS2B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for UTS2B Gene

Orthologs for UTS2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for UTS2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTS2D 34 35
  • 98.6 (n)
dog
(Canis familiaris)
Mammalia UTS2B 34 35
  • 82.35 (n)
cow
(Bos Taurus)
Mammalia UTS2B 34 35
  • 81.51 (n)
rat
(Rattus norvegicus)
Mammalia Uts2b 34
  • 72.08 (n)
mouse
(Mus musculus)
Mammalia Uts2b 34 16 35
  • 69.05 (n)
chicken
(Gallus gallus)
Aves UTS2D 34 35
  • 58.48 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia uts2b 34
  • 59.32 (n)
Species where no ortholog for UTS2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UTS2B Gene

ENSEMBL:
Gene Tree for UTS2B (if available)
TreeFam:
Gene Tree for UTS2B (if available)

Paralogs for UTS2B Gene

No data available for Paralogs for UTS2B Gene

Variants for UTS2B Gene

Sequence variations from dbSNP and Humsavar for UTS2B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs9847278 Benign 191,329,743(+) GGGAG(A/G)GCGCG intron-variant, upstream-variant-2KB
rs10580681 -- 191,329,978(+) CAAGT(-/AGGT)GGCTG intron-variant, upstream-variant-2KB
rs10669169 -- 191,319,718(+) AAAAA(-/AA)TTAGC intron-variant
rs10755146 -- 191,267,369(+) TATCA(C/T)AATTG utr-variant-3-prime
rs10804933 -- 191,268,321(+) TTCCA(C/T)AGCAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UTS2B Gene

Variant ID Type Subtype PubMed ID
esv2668071 CNV deletion 23128226
esv26911 CNV loss 19812545
esv2759209 CNV gain+loss 17122850
esv2763330 CNV loss 21179565
esv3304195 CNV mobile element insertion 20981092
esv3308454 CNV mobile element insertion 20981092
esv3365700 CNV insertion 20981092
esv3404133 CNV insertion 20981092
esv3599089 CNV loss 21293372
esv3599090 CNV gain 21293372
esv3599094 CNV loss 21293372
esv3599095 CNV loss 21293372
esv3599096 CNV gain 21293372
esv3599098 CNV loss 21293372
esv3599099 CNV gain 21293372
esv3599101 CNV loss 21293372
esv3599102 CNV loss 21293372
esv3599103 CNV gain 21293372
esv7437 CNV gain 19470904
nsv1012488 CNV loss 25217958
nsv10369 CNV loss 18304495
nsv10370 CNV loss 18304495
nsv4169 CNV deletion 18451855
nsv428428 CNV gain 18775914
nsv509873 OTHER sequence alteration 20534489
nsv997716 CNV loss 25217958
nsv998208 CNV gain 25217958

Variation tolerance for UTS2B Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 50.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTS2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTS2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTS2B Gene

Disorders for UTS2B Gene

Relevant External Links for UTS2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTS2B

No disorders were found for UTS2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTS2B Gene

Publications for UTS2B Gene

  1. Identification of urotensin II-related peptide as the urotensin II- immunoreactive molecule in the rat brain. (PMID: 14550283) Sugo T. … Fujino M. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Urotensin-II system in genetic control of blood pressure and renal function. (PMID: 24391740) Debiec R. … Tomaszewski M. (PLoS ONE 2013) 3 64
  4. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 3 64
  5. Human U2Ba8^ protein binding to snRNA stemloops. (PMID: 21684671) Williams S.G. … Hall K.B. (Biophys. Chem. 2011) 3 64

Products for UTS2B Gene

Sources for UTS2B Gene

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