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Aliases for UTS2B Gene

Aliases for UTS2B Gene

  • Urotensin 2B 2 3
  • Urotensin-2 Domain-Containing Protein 3 4
  • Urotensin 2 Domain Containing 2 3
  • Urotensin II-Related Peptide 3 4
  • Urotensin IIB 3 4
  • Prepro-URP 2 3

External Ids for UTS2B Gene

Previous HGNC Symbols for UTS2B Gene

  • UTS2D

Previous GeneCards Identifiers for UTS2B Gene

  • GC03M190985

Summaries for UTS2B Gene

GeneCards Summary for UTS2B Gene

UTS2B (Urotensin 2B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include hormone activity and G-protein coupled receptor binding.

UniProtKB/Swiss-Prot for UTS2B Gene

  • Potent vasoconstrictor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTS2B Gene

Genomics for UTS2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UTS2B Gene

Chromosome:
3
Start:
191,267,155 bp from pter
End:
191,330,536 bp from pter
Size:
63,382 bases
Orientation:
Minus strand

Genomic View for UTS2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UTS2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTS2B Gene

No data available for Regulatory Elements for UTS2B Gene

Proteins for UTS2B Gene

  • Protein details for UTS2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q765I0-UTS2B_HUMAN
    Recommended name:
    Urotensin-2B
    Protein Accession:
    Q765I0
    Secondary Accessions:
    • B3KQY8
    • D3DNW1
    • Q2M1Z2

    Protein attributes for UTS2B Gene

    Size:
    119 amino acids
    Molecular mass:
    13749 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UTS2B Gene

Proteomics data for UTS2B Gene at MOPED

Post-translational modifications for UTS2B Gene

No Post-translational modifications

Other Protein References for UTS2B Gene

No data available for DME Specific Peptides for UTS2B Gene

Domains & Families for UTS2B Gene

Gene Families for UTS2B Gene

Protein Domains for UTS2B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for UTS2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q765I0

UniProtKB/Swiss-Prot:

UTS2B_HUMAN :
  • Belongs to the urotensin-2 family.
Family:
  • Belongs to the urotensin-2 family.
genes like me logo Genes that share domains with UTS2B: view

Function for UTS2B Gene

Molecular function for UTS2B Gene

UniProtKB/Swiss-Prot Function:
Potent vasoconstrictor.

Gene Ontology (GO) - Molecular Function for UTS2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IEA --
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with UTS2B: view

Phenotypes for UTS2B Gene

GenomeRNAi human phenotypes for UTS2B:
genes like me logo Genes that share phenotypes with UTS2B: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UTS2B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UTS2B Gene

Localization for UTS2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTS2B Gene

Secreted.

Gene Ontology (GO) - Cellular Components for UTS2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with UTS2B: view

No data available for Subcellular locations from COMPARTMENTS for UTS2B Gene

Pathways & Interactions for UTS2B Gene

genes like me logo Genes that share pathways with UTS2B: view

Gene Ontology (GO) - Biological Process for UTS2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008217 regulation of blood pressure IEA --
GO:0042312 regulation of vasodilation IEA --
genes like me logo Genes that share ontologies with UTS2B: view

No data available for SIGNOR curated interactions for UTS2B Gene

Drugs & Compounds for UTS2B Gene

No Compound Related Data Available

Transcripts for UTS2B Gene

Unigene Clusters for UTS2B Gene

Urotensin 2B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UTS2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTS2B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: -
SP2: - - -
SP3:
SP4: - -

Relevant External Links for UTS2B Gene

GeneLoc Exon Structure for
UTS2B
ECgene alternative splicing isoforms for
UTS2B

Expression for UTS2B Gene

mRNA expression in normal human tissues for UTS2B Gene

mRNA differential expression in normal tissues according to GTEx for UTS2B Gene

This gene is overexpressed in Testis (x7.0) and Brain - Amygdala (x4.8).

Protein differential expression in normal tissues from HIPED for UTS2B Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UTS2B Gene



SOURCE GeneReport for Unigene cluster for UTS2B Gene Hs.518492

genes like me logo Genes that share expression patterns with UTS2B: view

Protein tissue co-expression partners for UTS2B Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for UTS2B Gene

Orthologs for UTS2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for UTS2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UTS2B 35
  • 81.51 (n)
  • 73.95 (a)
UTS2B 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UTS2B 35
  • 82.35 (n)
  • 74.79 (a)
UTS2B 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uts2b 35
  • 69.05 (n)
  • 50.89 (a)
Uts2d 16
Uts2b 36
  • 50 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UTS2D 35
  • 98.6 (n)
  • 96.64 (a)
UTS2D 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uts2b 35
  • 72.08 (n)
  • 55.56 (a)
chicken
(Gallus gallus)
Aves UTS2D 35
  • 58.48 (n)
  • 42.11 (a)
UTS2D 36
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uts2b 35
  • 59.32 (n)
  • 52.54 (a)
Species with no ortholog for UTS2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UTS2B Gene

ENSEMBL:
Gene Tree for UTS2B (if available)
TreeFam:
Gene Tree for UTS2B (if available)

Paralogs for UTS2B Gene

No data available for Paralogs for UTS2B Gene

Variants for UTS2B Gene

Sequence variations from dbSNP and Humsavar for UTS2B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs72344345 -- 191,295,038(+) TCTTA(-/AACAAC)AACAA intron-variant
rs72319687 -- 191,296,284(+) ACACA(-/CATACACACA)TACTC intron-variant
rs72278041 -- 191,307,823(+) TTTCT(-/TTTCG)TTTTC intron-variant
rs72268261 -- 191,267,794(+) GAGAT(-/AAG)AATTT cds-indel, downstream-variant-500B
rs71635353 -- 191,317,597(+) TGTTG(-/GA/TTGTTGTTC/TTGTTGTTG/TTGTTGTTGTTT)AGTTG intron-variant

Variation tolerance for UTS2B Gene

Residual Variation Intolerance Score: 84.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 50.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTS2B Gene

HapMap Linkage Disequilibrium report
UTS2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UTS2B Gene

Disorders for UTS2B Gene

Relevant External Links for UTS2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTS2B
genes like me logo Genes that share disorders with UTS2B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTS2B Gene

Publications for UTS2B Gene

  1. Identification of urotensin II-related peptide as the urotensin II- immunoreactive molecule in the rat brain. (PMID: 14550283) Sugo T. … Fujino M. (Biochem. Biophys. Res. Commun. 2003) 2 23 67
  2. The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation. (PMID: 20192922) Jarry M. … Gandolfo P. (Biochem. J. 2010) 23 67
  3. Biological properties and functional determinants of the urotensin II receptor. (PMID: 18155322) Proulx C.D. … Leduc R. (Peptides 2008) 23 67
  4. Biologically active peptides urotensin II (UII) and urotensin II-related peptide (URP), and to their cognate receptor (UT). Editorial. (PMID: 18314224) Vaudry H. (Peptides 2008) 23 67
  5. New insight into the molecular evolution of the somatostatin family. (PMID: 18406049) Tostivint H. … Vaudry H. (Mol. Cell. Endocrinol. 2008) 23 67

Products for UTS2B Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate UTS2B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for UTS2B
    • Block miRNA regulation of UTS2B using miScript Target Protectors

    Sources for UTS2B Gene

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