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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UTS2B Gene

protein-coding   GIFtS: 40
GCID: GC03M190985

Urotensin 2B

(Previous name: urotensin 2 domain containing)
(Previous symbol: UTS2D)
  Search for UTS2B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Urotensin 2B1 2     Urotensin-2 Domain-Containing Protein2 3
UTS2D1 2 3     U-IIB2 3
Urotensin 2 Domain Containing1 2     UIIB2 3
prepro-URP1 2     URP2 3
Urotensin II-Related Peptide2 3     U2B2
Urotensin IIB2 3     urotensin-2B2

External Ids:    HGNC: 308941   Entrez Gene: 2573132   Ensembl: ENSG000001889587   UniProtKB: Q765I03   

Export aliases for UTS2B gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UTS2B Gene: 
UTS2B (urotensin 2B) is a protein-coding gene. Among its related super-pathways are Signaling by GPCR and GPCR ligand binding.

UniProtKB/Swiss-Prot: UTS2B_HUMAN, Q765I0
Function: Potent vasoconstrictor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for UTS2B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUTS2B promoter sequence
   Search SABiosciences Chromatin IP Primers for UTS2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UTS2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28   Ensembl cytogenetic band:  3q28   HGNC cytogenetic band: 3q28

UTS2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UTS2B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M190985:  view genomic region     (about GC identifiers)

Start:
190,984,944 bp from pter      End:
191,048,325 bp from pter
Size:
63,382 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UTS2B_HUMAN, Q765I0 (See protein sequence)
Recommended Name: Urotensin-2B precursor  
Size: 119 amino acids; 13749 Da
Subcellular location: Secreted (By similarity)
Secondary accessions: B3KQY8 D3DNW1 Q2M1Z2

Explore the universe of human proteins at neXtProt for UTS2B: NX_Q765I0

Explore proteomics data for UTS2B at MOPED 

UTS2B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

UTS2B Protein Expression

REFSEQ proteins: NP_937795.2  
ENSEMBL proteins: 
 ENSP00000340526   ENSP00000398540   ENSP00000415628   ENSP00000398761   ENSP00000404406  
 ENSP00000401028  
Reactome Protein details: Q765I0
Human Recombinant Protein Products for UTS2B: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--

UTS2B for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ENDOLIG: Endogenous ligands

1 InterPro protein domain:
 IPR001483 Urotensin_II

Graphical View of Domain Structure for InterPro Entry Q765I0

ProtoNet protein and cluster: Q765I0

1 Blocks protein domain: IPB001483 Urotensin II

UniProtKB/Swiss-Prot: UTS2B_HUMAN, Q765I0
Similarity: Belongs to the urotensin-2 family


UTS2B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: UTS2B_HUMAN, Q765I0
Function: Potent vasoconstrictor (By similarity)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001664G-protein coupled receptor binding IEA--
GO:0005179hormone activity IEA--
     
UTS2B for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for UTS2B About                                                                                                See pathways by source

SuperPathContained pathways About
1Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
2Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
3G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK0.90
G alpha (q) signalling events0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


5/8        Reactome Pathways for UTS2B (see all 8)
    GPCR downstream signaling
Peptide ligand-binding receptors
Gastrin-CREB signalling pathway via PKC and MAPK
Signaling by GPCR
GPCR ligand binding



UTS2B for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UTS2B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/123 Interacting proteins for UTS2B (Q765I03 ENSP000003405264) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
InteractantInteraction Details
GeneCardExternal ID(s)
UTS2RQ9UKP63, ENSP000003235164I2D: score=2 STRING: ENSP00000323516
ADRA1DENSP000003687664STRING: ENSP00000368766
CCKENSP000003356574STRING: ENSP00000335657
EDN1ENSP000003686834STRING: ENSP00000368683
EDN3ENSP000003371284STRING: ENSP00000337128
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008217regulation of blood pressure IEA--
GO:0042312regulation of vasodilation IEA--

UTS2B for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UTS2B

Search CenterWatch for drugs/clinical trials and news about UTS2B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UTS2B gene: 
NM_198152.3  

Unigene Cluster for UTS2B:

Urotensin 2B
Hs.518492  [show with all ESTs]
Unigene Representative Sequence: NM_198152
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000340524(uc003fsu.3) ENST00000440476 ENST00000446788 ENST00000427544
ENST00000425357 ENST00000463450 ENST00000432514 ENST00000490825 ENST00000464814

miRNA
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Inhib. RNA
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Additional mRNA sequence: 

AB116021.1 AK090630.1 AY321313.1 BC112166.1 

3 DOTS entries:

DT.40112347  DT.120881781  DT.92025937 

24/25 AceView cDNA sequences (see all 25):

AX746546 AB116021 BI523816 BG719868 AK090630 BF699233 BG501297 AY321313 
NM_198152 BQ021661 AI472863 AA443532 BQ001512 BQ000995 BX108280 N35184 
BF700173 BI461754 BF670238 N23399 BF696056 BF696740 BF666778 BF700805 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for UTS2B    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1:                    -                                       
SP2:                    -           -     -                     
SP3:                                                            
SP4:                                -     -                     


ECgene alternative splicing isoforms for UTS2B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UTS2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
UTS2B Expression
About this image


See UTS2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UTS2B

SOURCE GeneReport for Unigene cluster: Hs.518492
    SABiosciences Custom PCR Arrays for UTS2B
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for UTS2B gene from 3/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Uts2d1 , 5 urotensin 2 domain containing1, 5 69.05(n)1
50.89(a)1
  16 (18.93 cM)5
2240651  NM_198166.31  NP_937809.11 
 273533225 
chicken
(Gallus gallus)
Aves UTS2D1 urotensin 2 domain containing 58.48(n)
42.11(a)
  404534  NM_206989.1  NP_996872.1 
African clawed frog
(Xenopus laevis)
Amphibia BJ084121.12   -- 80.36(n)    BJ084121.1 


ENSEMBL Gene Tree for UTS2B (if available)
TreeFam Gene Tree for UTS2B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1462 SNPs in UTS2B are shown (see all 1462)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1434120591,2
C--190984504(+) AAATT-/TTAA  
        
TTGAC
1 -- ds50010--------
rs1473610061,2
C--190984506(+) ATTTT-/AATT  
        
GACTA
1 -- ds50010--------
rs105749911,2
C--190984509(+) ATTTT-/A/AATT
        
GACTA
1 -- ds50011NA 2
rs124921451,2
C,F,H--190984601(+) TTTTGG/CGGTTT 1 -- ds50018Minor allele frequency- C:0.16EA NS NA CSA WA 546
rs1853918571,2
--190984635(+) ACTGTA/GTCTAA 1 -- ds50010--------
rs1898552351,2
--190984787(+) TCCCCA/TGAGTT 1 -- ds50010--------
rs2001497391,2
--190984809(+) TTCTG-/CCTTAG 1 -- ds50010--------
rs113882711,2
C--190984810(+) TCTGCT/-TTAGT 1 -- ds50011Minor allele frequency- -:0.00NA 2
rs1822492051,2
--190984901(+) AATGAA/GAAAGA 1 -- ds50010--------
rs11295861,2
C,F,O,A,H--190985047(-) TCTATT/CGTATG 1 -- ut3132Minor allele frequency- C:0.16NS MN NA EA WA 2902

HapMap Linkage Disequilibrium report for UTS2B (190984944 - 191048325 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for UTS2B: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing UTS2B
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for UTS2B gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with UTS2B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of urotensin II-related peptide as the urotensin II- immunoreactive molecule in the rat brain. (PubMed id 14550283)1, 2, 3, 9 Sugo T.... Fujino M. (2003)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. (PubMed id 23562540)1 Cruchaga C....Goate A.M. (2013)
  4. Human U2Ba8^ protein binding to snRNA stemloops. (PubMed id 21684671)1 Williams S.G. and Hall K.B. (2011)
  5. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)1 Furney S.J....Lovestone S. (2010)
  6. Urotensin II: a novel vasoactive mediator linked to chronic liver disease and portal hypertension. (PubMed id 17919235)1 Kemp W....Roberts S. (2007)
  7. Urotensin-II in the lung: a matter for vascular remodelling and pulmonary hypertension? (PubMed id 18000598)1 Djordjevic T. and Gorlach A. (2007)
  8. Human urotensin II as a link between hypertension and coronary artery disease. (PubMed id 16940699)1 Watanabe T....Katagiri T. (2006)
  9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  10. [Role of urotensin II gene in the genetic susceptibility to gestational diabetes mellitus in northern Chinese women] (PubMed id 17327028)1 Tan Y.J....Yang H.X. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 257313 HGNC: 30894 AceView: URP Ensembl:ENSG00000188958 euGenes: HUgn257313
ECgene: UTS2B H-InvDB: UTS2B

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for UTS2B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for UTS2B gene:
Search GeneIP for patents involving UTS2B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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