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Aliases for UTS2 Gene

Aliases for UTS2 Gene

  • Urotensin 2 2 3
  • Urotensin II 3 4
  • Prepro U-II 2 3
  • U-II 3 4
  • UII 3 4
  • Urotensin-2 3
  • PRO1068 3
  • UCN2 3

External Ids for UTS2 Gene

Previous GeneCards Identifiers for UTS2 Gene

  • GC01M007485
  • GC01M007716
  • GC01M007617
  • GC01M007841
  • GC01M007055

Summaries for UTS2 Gene

Entrez Gene Summary for UTS2 Gene

  • This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UTS2 Gene

UTS2 (Urotensin 2) is a Protein Coding gene. Diseases associated with UTS2 include portal hypertension and congestive heart failure. Among its related pathways are Signaling by GPCR and NF-KappaB Family Pathway. GO annotations related to this gene include receptor binding and hormone activity.

UniProtKB/Swiss-Prot for UTS2 Gene

  • Highly potent vasoconstrictor

Tocris Summary for UTS2 Gene

Gene Wiki entry for UTS2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTS2 Gene

Genomics for UTS2 Gene

Regulatory Elements for UTS2 Gene

Genomic Location for UTS2 Gene

7,843,083 bp from pter
7,853,512 bp from pter
10,430 bases
Minus strand

Genomic View for UTS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UTS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTS2 Gene

Proteins for UTS2 Gene

  • Protein details for UTS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5H8X7
    • Q6UXF6
    • Q9UKP7

    Protein attributes for UTS2 Gene

    124 amino acids
    Molecular mass:
    14296 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UTS2 Gene


neXtProt entry for UTS2 Gene

Proteomics data for UTS2 Gene at MOPED

Post-translational modifications for UTS2 Gene

No Post-translational modifications

Other Protein References for UTS2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for UTS2 Gene

Domains for UTS2 Gene

Gene Families for UTS2 Gene

Protein Domains for UTS2 Gene


Suggested Antigen Peptide Sequences for UTS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the urotensin-2 family.
  • Belongs to the urotensin-2 family.
genes like me logo Genes that share domains with UTS2: view

Function for UTS2 Gene

Molecular function for UTS2 Gene

UniProtKB/Swiss-Prot Function:
Highly potent vasoconstrictor

Gene Ontology (GO) - Molecular Function for UTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10499587
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with UTS2: view

Phenotypes for UTS2 Gene

GenomeRNAi human phenotypes for UTS2:
genes like me logo Genes that share phenotypes with UTS2: view

Animal Model Products

miRNA for UTS2 Gene

miRTarBase miRNAs that target UTS2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UTS2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for UTS2 Gene

Localization for UTS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTS2 Gene


Subcellular locations from

Jensen Localization Image for UTS2 Gene COMPARTMENTS Subcellular localization image for UTS2 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with UTS2: view

Pathways for UTS2 Gene

genes like me logo Genes that share pathways with UTS2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for UTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0003105 negative regulation of glomerular filtration IEA --
GO:0006936 muscle contraction TAS 10499587
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0007268 synaptic transmission TAS 10499587
genes like me logo Genes that share ontologies with UTS2: view

Drugs for UTS2 Gene

(5) Tocris Compounds for UTS2 Gene

Compound Action Cas Number
[Orn5]-URP Urotensin-II (UT) receptor antagonist [782485-03-4]
GSK 1562590 hydrochloride High affinity, selective urotensin II (UT) receptor antagonist [1003878-07-6]
SB 611812 Urotensin-II (UT) antagonist; attenuates cardiac dysfunction [345892-71-9]
SB 706375 High affinity, non-peptide UT receptor antagonist [733734-61-7]
Urotensin II-related peptide Endogenous urotensin-II receptor agonist [342878-90-4]

(33) Novoseek inferred chemical compound relationships for UTS2 Gene

Compound -log(P) Hits PubMed IDs
palosuran 95.1 14
ro 31 8220 47.6 2
pd 98,059 43.8 3
radicicol 43.7 2
n(g)-nitro-l-arginine methyl ester 35.2 2
genes like me logo Genes that share compounds with UTS2: view

Transcripts for UTS2 Gene

Unigene Clusters for UTS2 Gene

Urotensin 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UTS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTS2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2: -

Relevant External Links for UTS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UTS2 Gene

mRNA expression in normal human tissues for UTS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UTS2 Gene

This gene is overexpressed in Whole Blood (11.3), Brain - Spinal cord (cervical c-1) (9.2), Adrenal Gland (6.1), and Brain - Hypothalamus (5.6).

Protein differential expression in normal tissues for UTS2 Gene

This gene is overexpressed in Stomach (10.0) and Pancreas (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UTS2 Gene

SOURCE GeneReport for Unigene cluster for UTS2 Gene Hs.715862

mRNA Expression by UniProt/SwissProt for UTS2 Gene

Tissue specificity: Brain specific
genes like me logo Genes that share expressions with UTS2: view

Expression partners for UTS2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for UTS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UTS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UTS2 35
  • 81.57 (n)
  • 71.54 (a)
(Canis familiaris)
Mammalia UTS2 35
  • 76.15 (n)
  • 64.23 (a)
(Mus musculus)
Mammalia Uts2 35
  • 65.57 (n)
  • 50.82 (a)
Uts2 16
Uts2 36
  • 41 (a)
(Rattus norvegicus)
Mammalia Uts2 35
  • 67.76 (n)
  • 50.82 (a)
(Monodelphis domestica)
Mammalia UTS2 36
  • 42 (a)
(Ornithorhynchus anatinus)
Mammalia UTS2 36
  • 43 (a)
(Pan troglodytes)
Mammalia UTS2 36
  • 70 (a)
(Gallus gallus)
Aves UTS2 36
  • 40 (a)
Species with no ortholog for UTS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UTS2 Gene

Gene Tree for UTS2 (if available)
Gene Tree for UTS2 (if available)

Paralogs for UTS2 Gene

No data available for Paralogs for UTS2 Gene

Variants for UTS2 Gene

Sequence variations from dbSNP and Humsavar for UTS2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs170629 -- 7,850,331(-) CGTGG(C/T)CACAT intron-variant
rs179264 -- 7,854,989(-) gagac(A/G)gggtt upstream-variant-2KB
rs186634 -- 7,848,807(-) gggtg(C/T)ggtgg intron-variant
rs228647 -- 7,854,117(+) gaggc(A/G)gatgg upstream-variant-2KB
rs228648 -- 7,853,370(+) GAGAC(A/G)TGGAT upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for UTS2 Gene

Variant ID Type Subtype PubMed ID
nsv870846 CNV Loss 21882294
esv2660700 CNV Deletion 23128226

Relevant External Links for UTS2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTS2 Gene

Disorders for UTS2 Gene

(4) University of Copenhagen DISEASES for UTS2 Gene

(41) Novoseek inferred disease relationships for UTS2 Gene

Disease -log(P) Hits PubMed IDs
coronary atheroma 57 2
heart failure 53.5 32
hypertension portal 51 14
cardiovascular diseases 46.7 32
effects cardiovascular 45.1 9

Relevant External Links for UTS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with UTS2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for UTS2 Gene

Publications for UTS2 Gene

  1. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. (PMID: 10499587) Ames R.S. … Douglas S.A. (Nature 1999) 2 3 4 23
  2. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. (PMID: 9861051) Coulouarn Y. … Vaudry H. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23
  3. Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance. (PMID: 16597476) Ong K.L. … Cheung B.M. (Peptides 2006) 3 23 48
  4. Association of ACE, ACE2 and UTS2 polymorphisms with essential hypertension in Han and Dongxiang populations from north-western China. (PMID: 16866021) Yi L. … Zhang D.L. (J. Int. Med. Res. 2006) 3 23 48
  5. Role of urotensin II gene in genetic susceptibility to Type 2 diabetes mellitus in Japanese subjects. (PMID: 12830381) Wenyi Z. … Oka Y. (Diabetologia 2003) 3 23 48

Products for UTS2 Gene

Sources for UTS2 Gene

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