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Aliases for UTS2 Gene

Aliases for UTS2 Gene

  • Urotensin 2 2 3
  • Urotensin II 3 4
  • Prepro U-II 2 3
  • U-II 3 4
  • UII 3 4
  • PRO1068 3
  • UCN2 3

External Ids for UTS2 Gene

Previous GeneCards Identifiers for UTS2 Gene

  • GC01M007485
  • GC01M007716
  • GC01M007617
  • GC01M007841
  • GC01M007055

Summaries for UTS2 Gene

Entrez Gene Summary for UTS2 Gene

  • This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UTS2 Gene

UTS2 (Urotensin 2) is a Protein Coding gene. Diseases associated with UTS2 include portal hypertension and hepatic vascular disease. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include receptor binding and hormone activity.

UniProtKB/Swiss-Prot for UTS2 Gene

  • Highly potent vasoconstrictor

Tocris Summary for UTS2 Gene

  • The urotensin-II (UT) receptor is a Gq/11-protein-coupled receptor that mediates complex hemodynamic effects and influences neuromuscular physiology. The UT receptor displays greatest expression levels in the peripheral vasculature, heart and kidney.

Gene Wiki entry for UTS2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTS2 Gene

Genomics for UTS2 Gene

Regulatory Elements for UTS2 Gene

Genomic Location for UTS2 Gene

Chromosome:
1
Start:
7,843,083 bp from pter
End:
7,913,610 bp from pter
Size:
70,528 bases
Orientation:
Minus strand

Genomic View for UTS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UTS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTS2 Gene

Proteins for UTS2 Gene

  • Protein details for UTS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95399-UTS2_HUMAN
    Recommended name:
    Urotensin-2
    Protein Accession:
    O95399
    Secondary Accessions:
    • Q5H8X7
    • Q6UXF6
    • Q9UKP7

    Protein attributes for UTS2 Gene

    Size:
    124 amino acids
    Molecular mass:
    14296 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UTS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UTS2 Gene

Proteomics data for UTS2 Gene at MOPED

Post-translational modifications for UTS2 Gene

No Post-translational modifications

Other Protein References for UTS2 Gene

No data available for DME Specific Peptides for UTS2 Gene

Domains & Families for UTS2 Gene

Gene Families for UTS2 Gene

Protein Domains for UTS2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for UTS2 Gene

Graphical View of Domain Structure for InterPro Entry

O95399

UniProtKB/Swiss-Prot:

UTS2_HUMAN :
  • Belongs to the urotensin-2 family.
Family:
  • Belongs to the urotensin-2 family.
genes like me logo Genes that share domains with UTS2: view

Function for UTS2 Gene

Molecular function for UTS2 Gene

UniProtKB/Swiss-Prot Function:
Highly potent vasoconstrictor

Gene Ontology (GO) - Molecular Function for UTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10499587
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with UTS2: view
genes like me logo Genes that share phenotypes with UTS2: view

Animal Model Products

miRNA for UTS2 Gene

miRTarBase miRNAs that target UTS2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UTS2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for UTS2 Gene

Localization for UTS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTS2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UTS2 Gene COMPARTMENTS Subcellular localization image for UTS2 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with UTS2: view

Pathways & Interactions for UTS2 Gene

genes like me logo Genes that share pathways with UTS2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for UTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0003105 negative regulation of glomerular filtration IEA --
GO:0006936 muscle contraction TAS 10499587
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0007268 synaptic transmission TAS 10499587
genes like me logo Genes that share ontologies with UTS2: view

No data available for SIGNOR curated interactions for UTS2 Gene

Drugs & Compounds for UTS2 Gene

(17) Drugs for UTS2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atropine Approved Pharma Antagonist MAChRs antagonist 101
Indomethacin Approved, Investigational Pharma Inhibition, Inhibitor Cox inhibitor 97
Nitric Oxide Approved Pharma 540
Norepinephrine Approved Pharma 206
Octreotide Approved, Investigational Pharma Full agonist, Agonist sst2, sst3 and sst5 agonist 191

(21) Additional Compounds for UTS2 Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-AC 7954 hydrochloride
477313-09-0
[Orn5]-URP
782485-03-4
[Orn8]-Urotensin II
479065-85-5
UFP 803
879497-82-2
Urotensin II (human)
251293-28-4
genes like me logo Genes that share compounds with UTS2: view

Transcripts for UTS2 Gene

Unigene Clusters for UTS2 Gene

Urotensin 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UTS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTS2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2: -

Relevant External Links for UTS2 Gene

GeneLoc Exon Structure for
UTS2
ECgene alternative splicing isoforms for
UTS2

Expression for UTS2 Gene

mRNA expression in normal human tissues for UTS2 Gene

mRNA differential expression in normal tissues according to GTEx for UTS2 Gene

This gene is overexpressed in Whole Blood (x11.3), Brain - Spinal cord (cervical c-1) (x9.2), Adrenal Gland (x6.1), and Brain - Hypothalamus (x5.6).

Protein differential expression in normal tissues from HIPED for UTS2 Gene

This gene is overexpressed in Stomach (10.0) and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UTS2 Gene



SOURCE GeneReport for Unigene cluster for UTS2 Gene Hs.715862

mRNA Expression by UniProt/SwissProt for UTS2 Gene

O95399-UTS2_HUMAN
Tissue specificity: Brain specific
genes like me logo Genes that share expression patterns with UTS2: view

Protein tissue co-expression partners for UTS2 Gene

Primer Products

In Situ Assay Products

Orthologs for UTS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UTS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UTS2 35
  • 81.57 (n)
  • 71.54 (a)
dog
(Canis familiaris)
Mammalia UTS2 35
  • 76.15 (n)
  • 64.23 (a)
mouse
(Mus musculus)
Mammalia Uts2 35
  • 65.57 (n)
  • 50.82 (a)
Uts2 16
Uts2 36
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uts2 35
  • 67.76 (n)
  • 50.82 (a)
oppossum
(Monodelphis domestica)
Mammalia UTS2 36
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UTS2 36
  • 43 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UTS2 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves UTS2 36
  • 40 (a)
OneToOne
Species with no ortholog for UTS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UTS2 Gene

ENSEMBL:
Gene Tree for UTS2 (if available)
TreeFam:
Gene Tree for UTS2 (if available)

Paralogs for UTS2 Gene

No data available for Paralogs for UTS2 Gene

Variants for UTS2 Gene

Sequence variations from dbSNP and Humsavar for UTS2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs106968 -- 7,914,484(-) CCAAC(C/G)TGTTA upstream-variant-2KB
rs129818 -- 7,874,767(-) tcccc(G/T)gacac intron-variant
rs170550 -- 7,894,587(+) CCCCC(C/T)GGCCC intron-variant
rs170551 -- 7,895,834(+) AAATT(A/G)CATGA intron-variant
rs170627 -- 7,860,267(+) Cagcg(C/T)aggct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UTS2 Gene

Variant ID Type Subtype PubMed ID
nsv870846 CNV Loss 21882294
esv2660700 CNV Deletion 23128226

Variation tolerance for UTS2 Gene

Residual Variation Intolerance Score: 87.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.90; 91.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTS2 Gene

HapMap Linkage Disequilibrium report
UTS2
Human Gene Mutation Database (HGMD)
UTS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTS2 Gene

Disorders for UTS2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for UTS2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
portal hypertension
  • hypertension, portal
hepatic vascular disease
  • vascular disorder of liver
congestive heart failure
  • chf
liver cirrhosis
  • cirrhosis of liver
congenital heart disease
  • congestive heart failure
- elite association
Search UTS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UTS2

Genetic Association Database (GAD)
UTS2
Human Genome Epidemiology (HuGE) Navigator
UTS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTS2
genes like me logo Genes that share disorders with UTS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UTS2 Gene

Publications for UTS2 Gene

  1. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. (PMID: 10499587) Ames R.S. … Douglas S.A. (Nature 1999) 2 23 67
  2. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. (PMID: 9861051) Coulouarn Y. … Vaudry H. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 23 67
  3. Expression of urotensin II and its receptor in human liver cirrhosis and fulminant hepatic failure. (PMID: 19582578) Leifeld L. … Spengler U. (Dig. Dis. Sci. 2010) 23 67
  4. Kidney is in trouble with mediators. (PMID: 20433427) Balat A. (Bosn J Basic Med Sci 2010) 23 67
  5. Urotensin II stimulates high frequency-induced ANP secretion via PLC-PI 3K-PKC pathway. (PMID: 19896516) Gao S. … Kim S.H. (Peptides 2010) 23 67

Products for UTS2 Gene

Sources for UTS2 Gene

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