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UTS2 Gene

protein-coding   GIFtS: 54
GCID: GC01M007904

Urotensin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Urotensin 21 2     UII2 3
Prepro U-II1 2     PRO10682
Urotensin II2 3     UCN22
U-II2 3     urotensin-22

External Ids:    HGNC: 126361   Entrez Gene: 109112   Ensembl: ENSG000000492477   OMIM: 6040975   UniProtKB: O953993   

Export aliases for UTS2 gene to outside databases

Previous GC identifers: GC01M007485 GC01M007716 GC01M007617 GC01M007841 GC01M007055


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UTS2 Gene:
This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to
human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene
family name similarity, this gene is not homologous to urocortin, a member of the
sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature
peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for UTS2 Gene:
UTS2 (urotensin 2) is a protein-coding gene. Diseases associated with UTS2 include portal hypertension, and congestive heart failure. GO annotations related to this gene include hormone activity and receptor binding.

UniProtKB/Swiss-Prot: UTS2_HUMAN, O95399
Function: Highly potent vasoconstrictor

Gene Wiki entry for UTS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the UTS2 gene promoter:
         ATF-2   Hand1   FOXD1   CUTL1   E47   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUTS2 promoter sequence
   Search Chromatin IP Primers for UTS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UTS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36

UTS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UTS2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M007904:  view genomic region     (about GC identifiers)

Start:
7,903,143 bp from pter      End:
7,913,572 bp from pter
Size:
10,430 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UTS2_HUMAN, O95399 (See protein sequence)
Recommended Name: Urotensin-2 precursor  
Size: 124 amino acids; 14296 Da
Secondary accessions: Q5H8X7 Q6UXF6 Q9UKP7
Alternative splicing: 2 isoforms:  O95399-1   O95399-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UTS2: NX_O95399

Explore proteomics data for UTS2 at MOPED


See UTS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_006777.1  NP_068835.1  

ENSEMBL proteins: 
 ENSP00000366738   ENSP00000355163   ENSP00000054668  
Reactome Protein details: O95399

UTS2 Human Recombinant Protein Products:

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Novus Biologicals UTS2 Protein
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

UTS2 Antibody Products:

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Abcam antibodies for UTS2
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ThermoFisher Antibodies for UTS2
LSBio Antibodies in human, mouse, rat for UTS2

UTS2 Assay Products:

Browse Kits and Assays available from EMD Millipore
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Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for UTS2
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands

1 InterPro protein domain:
 IPR001483 Urotensin_II

Graphical View of Domain Structure for InterPro Entry O95399

ProtoNet protein and cluster: O95399

1 Blocks protein domain: IPB001483 Urotensin II

UniProtKB/Swiss-Prot: UTS2_HUMAN, O95399
Similarity: Belongs to the urotensin-2 family


UTS2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: UTS2_HUMAN, O95399
Function: Highly potent vasoconstrictor

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005102receptor binding TAS10499587
GO:0005179hormone activity IEA--
     
UTS2 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for UTS2:
 Synthetic lethal with c-Myc af 

     1 MGI phenotypic allele for Uts2 (no phenotypes)

UTS2 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Uts2tm1Lex for UTS2

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UTS2
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UTS2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UTS2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UTS2

miRNA
Products:
    
miRTarBase miRNAs that target UTS2:
hsa-mir-148b-3p (MIRT019441), hsa-mir-335-5p (MIRT018692)

Block miRNA regulation of human, mouse, rat UTS2 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate UTS2:
hsa-miR-607 hsa-miR-376c hsa-miR-877
SwitchGear 3'UTR luciferase reporter plasmidUTS2 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for UTS2
Predesigned siRNA for gene silencing in human, mouse, rat UTS2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for UTS2

Clone
Products:
     
OriGene clones in human, mouse for UTS2 (see all 10)
OriGene ORF clones in mouse, rat for UTS2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: UTS2 (NM_018949)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for UTS2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTS2

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for UTS2
Browse ESI BIO Cell Lines and PureStem Progenitors for UTS2 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTS2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
UTS2_HUMAN, O95399: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
cytosol1
nucleus1
peroxisome1
plasma membrane1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--

UTS2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for UTS2 About   (see all 16)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Apoptotic Pathways in Synovial Fibroblasts
Mitochondrial Apoptosis0.85
Rac1 Pathway0.65
Cellular Apoptosis Pathway0.85
Glioma Invasiveness0.64
Apoptotic Pathways in Synovial Fibroblasts0.84
Actin-Based Motility by Rho Family GTPases0.62
p53 Mediated Apoptosis0.84
ERK5 Signaling0.61
2GPCR Pathway
Ras Pathway0.73
Breast Cancer Regulation by Stathmin10.58
Paxillin Interactions0.73
NFAT in Immune Response0.58
GPCR Pathway0.62
Estrogen Pathway0.55
Pancreatic Adenocarcinoma0.59
3ERK Signaling
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61
ILK Signaling0.49
MAPK Signaling0.58
4Nanog in Mammalian ESC Pluripotency
Nanog in Mammalian ESC Pluripotency0.61
14-3-3 Induced Intracellular Signaling0.59
GSK3 Signaling0.61
eNOS Signaling0.48
5TGF-Beta Pathway
TGF-Beta Pathway0.60
JAK-STAT Pathway0.57
MAPK Family Pathway0.60
JNK Pathway0.51

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UTS2 (see all 55)
    Nuclear Receptor Activation by Vitamin-A
Paxillin Interactions
Telomerase Components in Cell Signaling
Mitochondrial Apoptosis
Molecular Mechanisms of Cancer

2 Reactome Pathways for UTS2
    Peptide ligand-binding receptors
G alpha (q) signalling events



UTS2 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Arrays including UTS2: 
          Hypertension in human mouse rat
          T Helper Cell Differentiation in human mouse rat

Interactions:

    GeneGlobe Interaction Network for UTS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for UTS2 (O953993 ENSP000000546684) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
InteractantInteraction Details
GeneCardExternal ID(s)
UTS2RQ9UKP63, ENSP000003235164I2D: score=1 STRING: ENSP00000323516
ADRA1DENSP000003687664STRING: ENSP00000368766
ADRBK1ENSP000003122624STRING: ENSP00000312262
AGTR1ENSP000002734304STRING: ENSP00000273430
AVPR1AENSP000002991784STRING: ENSP00000299178
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Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001666response to hypoxia IEA--
GO:0003105negative regulation of glomerular filtration IEA--
GO:0006936muscle contraction TAS10499587
GO:0007204positive regulation of cytosolic calcium ion concentration IEA--
GO:0007268synaptic transmission TAS10499587

UTS2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for UTS2 available from Tocris Bioscience    About this table
CompoundAction CAS #
Urotensin II (human)Endogenous vasoactive agonist for the UT receptor[251293-28-4]
(+-)-AC 7954 hydrochlorideNon-peptide UT receptor agonist[477313-09-0]
SB 657510Selective urotensin-II (UT) receptor antagonist[474960-44-6]
[Orn8]-Urotensin IIUrotensin-II (UT) receptor partial agonist[479065-85-5]
SB 706375 High affinity, non-peptide UT receptor antagonist [733734-61-7]

Selected Novoseek inferred chemical compound relationships for UTS2 gene (see all 33)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
palosuran 95.1 31 18318439 (4), 17931748 (3), 18473773 (2), 19843053 (1) (see all 8)
ro 31 8220 47.6 2 17283870 (1), 11435331 (1)
pd 98,059 43.8 3 12503613 (1), 16172428 (1), 17283870 (1)
radicicol 43.7 2 17283870 (1), 11435331 (1)
n(g)-nitro-l-arginine methyl ester 35.2 2 17241524 (1), 17687407 (1)
nitric oxide 28.6 20 20433427 (2), 17687407 (2), 10940376 (1), 10952676 (1) (see all 11)
gdp(beta-s) 23.4 2 16172428 (1), 17283870 (1)
indomethacin 21.5 1 11020490 (1)
d penicillamine 16.4 4 17064254 (1), 12238917 (1)
calcium 15.1 20 18314227 (5), 14733770 (2), 20192922 (2), 17241524 (2) (see all 11)



UTS2 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for UTS2 gene (2 alternative transcripts): 
NM_006786.3  NM_021995.2  

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000377516(uc001aos.3 uc001aoq.3) ENST00000361696(uc001aor.3)
ENST00000054668
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat UTS2 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate UTS2:
hsa-miR-607 hsa-miR-376c hsa-miR-877
SwitchGear 3'UTR luciferase reporter plasmidUTS2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for UTS2
Predesigned siRNA for gene silencing in human, mouse, rat UTS2
Clone
Products:
     
OriGene clones in human, mouse for UTS2 (see all 10)
OriGene ORF clones in mouse, rat for UTS2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: UTS2 (NM_018949)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for UTS2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTS2
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for UTS2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UTS2
  QuantiTect SYBR Green Assays in human, mouse, rat UTS2
  QuantiFast Probe-based Assays in human, mouse, rat UTS2

21 AceView cDNA sequences:

NM_021995 AW007125 BX100218 BE674622 BC025776 NM_006786 AF104118 AF140630 
BQ227518 AA535545 AW971501 AY358375 CK821319 BI837862 AI797558 AI797490 
BM804451 AI825099 AV755530 AW452037 BE167960 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for UTS2    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1:                          -         
SP2:        -                           


ECgene alternative splicing isoforms for UTS2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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UTS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAAACCATTA
UTS2 Expression
About this image


UTS2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Neurons
         Ventral/hypothalamic-like neurons
 
 Brain (Nervous System)
         Ventral/hypothalamic-like neurons
 
 Spinal Cord (Nervous System)
UTS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

UTS2 Protein Expression

UniProtKB/Swiss-Prot: UTS2_HUMAN, O95399
Tissue specificity: Brain specific

    Pathway & Disease-focused RT2 Profiler PCR Arrays including UTS2: 
          Hypertension in human mouse rat
          T Helper Cell Differentiation in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for UTS2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UTS2
QuantiTect SYBR Green Assays in human, mouse, rat UTS2
QuantiFast Probe-based Assays in human, mouse, rat UTS2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTS2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for UTS2 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Uts21 , 5 urotensin 21, 5 65.57(n)1
50.82(a)1
  4 (81.53 cM)5
241111  NM_011910.21  NP_036040.11 
 1509970975 
chicken
(Gallus gallus)
Aves UTS26
Gallus gallus urotensin 2 (UTS2), mRNA.
40(a)
1 ↔ 1
21(283153-286467)


ENSEMBL Gene Tree for UTS2 (if available)
TreeFam Gene Tree for UTS2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for UTS2 (see all 220)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs766584511,2
F--7907226(+) ATTCTC/TGTGCC 2 -- ds50011Minor allele frequency- T:0.03WA 118
rs1500753381,2
C--7907301(+) TGGTAA/GAGACA 2 -- ds50010--------
rs2286801,2
C,F,A,H--7907321(+) CATGTT/CCCCAG 2 -- ds500111Minor allele frequency- C:0.38WA NA CSA EA 374
rs1162258741,2
F--7907468(+) AGGACA/GTCATA 2 -- ds50011Minor allele frequency- G:0.03WA 118
rs1434406821,2
C--7907620(+) AAGAA-/TAAT  
        
TAATT
2 -- ds50010--------
rs23075501,2
C--7907622(+) AATTAATTA/-  
        
TAAAT
2 -- ds50015Minor allele frequency- -:0.43EU NA EA 344
rs2002660061,2
C--7907627(+) AATTAA/TAAATT 2 -- ds50010--------
rs1128206911,2
C--7907805(+) CTGACT/-TAACA 2 -- ut311Minor allele frequency- -:0.50CSA 2
rs1503894161,2
C,F--7907918(+) GTTAGG/TATCTT 4 T P mis12Minor allele frequency- T:0.00NA EU 5865
rs1410214221,2
C,F--7907931(+) CCAGAG/TAAATC 4 L F mis11Minor allele frequency- T:0.00NA 4546

HapMap Linkage Disequilibrium report for UTS2 (7903143 - 7913572 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for UTS2:    About this table    
Variant IDTypeSubtypePubMed ID
esv2660700CNV Deletion23128226
nsv870846CNV Loss21882294

Human Gene Mutation Database (HGMD): UTS2
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing UTS2
DNA2.0 Custom Variant and Variant Library Synthesis for UTS2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604097    OMIM disorders: --

Selected diseases for UTS2 (see all 41):    
About MalaCards
portal hypertension    congestive heart failure    somatostatin analog    pheochromocytoma
essential hypertension    diabetic nephropathy    adrenocortical carcinoma    proteinuria
liver cirrhosis    gestational diabetes    acute myocardial infarction    hypertension
pre-eclampsia    atherosclerosis    eclampsia    myocardial infarction
coronary artery disease    rhabdomyosarcoma    nephrotic syndrome    insulin resistance

4 diseases from the University of Copenhagen DISEASES database for UTS2:
Hypertension     Congestive heart failure     Portal hypertension     Atherosclerosis

UTS2 for disorders           About GeneDecksing

Selected Novoseek inferred disease relationships for UTS2 gene (see all 41)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
coronary atheroma 57 3 10499587 (1), 11435331 (1)
heart failure 53.5 42 12241661 (2), 15007012 (2), 17680191 (2), 17935830 (2) (see all 27)
hypertension portal 51 21 17919235 (3), 20428787 (3), 19797237 (2), 12445417 (1) (see all 9)
cardiovascular diseases 46.7 46 19199921 (3), 18284603 (2), 17139807 (2), 15476947 (2) (see all 25)
effects cardiovascular 45.1 16 11725162 (1), 12535707 (1), 15306183 (1), 14753294 (1) (see all 9)
atherosclerosis 43.9 43 15476944 (3), 17933432 (3), 15306183 (2), 16172428 (2) (see all 26)
essential hypertension 43 29 16866021 (4), 19199921 (3), 16940699 (3), 17261470 (2) (see all 8)
heart failure congestive 41.4 18 16364499 (3), 12581957 (2), 11708807 (1), 12710525 (1) (see all 13)
carcinoma adrenocortical 38.7 4 11445248 (2), 12668216 (1), 17686550 (1)
hypertension pulmonary 38.5 20 16631735 (3), 16324296 (3), 18000598 (2), 12381671 (1) (see all 7)

Genetic Association Database (GAD): UTS2
Human Genome Epidemiology (HuGE) Navigator: UTS2 (13 documents)

Export disorders for UTS2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for UTS2 gene, integrated from 10 sources (see all 277):
(articles sorted by number of sources associating them with UTS2)
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  1. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. (PubMed id 9861051)1, 2, 3, 9 Coulouarn Y.... Vaudry H. (Proc. Natl. Acad. Sci. U.S.A. 1998)
  2. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. (PubMed id 10499587)1, 2, 3, 9 Ames R.S....Douglas S.A. (Nature 1999)
  3. Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese. (PubMed id 15476949)1, 4, 9 Suzuki S....Oka Y. (Peptides 2004)
  4. Association of ACE, ACE2 and UTS2 polymorphisms with essential hypertension in Han and Dongxiang populations from north-western China. (PubMed id 16866021)1, 4, 9 Yi L....Zhang D.L. (J. Int. Med. Res. 2006)
  5. Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance. (PubMed id 16597476)1, 4, 9 Ong K.L....Cheung B.M. (Peptides 2006)
  6. Role of urotensin II gene in genetic susceptibility to Type 2 diabetes mellitus in Japanese subjects. (PubMed id 12830381)1, 4, 9 Wenyi Z....Oka Y. (Diabetologia 2003)
  7. Association between urotensin II gene polymorphism and pre-eclampsia. (PubMed id 20653105)1, 4 Dikensoy E....Balci S.O. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2010)
  8. Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2009)
  9. Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. (PubMed id 19056482)1, 4 Yoshida T....Yamada Y. (Genomics 2009)
  10. [Relationship between polymorphism of urotensin II gene and type 2 diabetes in pedigrees]. (PubMed id 18067077)1, 4 Wu X.J....Zhou L. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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  Query String
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10911 HGNC: 12636 AceView: UTS2 Ensembl:ENSG00000049247 euGenes: HUgn10911
ECgene: UTS2 H-InvDB: UTS2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for UTS2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for UTS2 gene:
Search GeneIP for patents involving UTS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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