Aliases for UTS2 Gene
External Ids for UTS2 Gene
Previous GeneCards Identifiers for UTS2 Gene
This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for UTS2 Gene
UTS2 (Urotensin 2) is a Protein Coding gene. Diseases associated with UTS2 include portal hypertension and congenital heart disease. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor binding and hormone activity.
UniProtKB/Swiss-Prot for UTS2 Gene
Highly potent vasoconstrictor.
The urotensin-II (UT) receptor is a Gq/11-protein-coupled receptor that mediates complex hemodynamic effects and influences neuromuscular physiology. The UT receptor displays greatest expression levels in the peripheral vasculature, heart and kidney.