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Aliases for UTS2 Gene

Aliases for UTS2 Gene

  • Urotensin 2 2 3 5
  • Urotensin II 3 4
  • Prepro U-II 2 3
  • U-II 3 4
  • UII 3 4
  • PRO1068 3
  • UCN2 3

External Ids for UTS2 Gene

Previous GeneCards Identifiers for UTS2 Gene

  • GC01M007485
  • GC01M007716
  • GC01M007617
  • GC01M007841
  • GC01M007055

Summaries for UTS2 Gene

Entrez Gene Summary for UTS2 Gene

  • This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UTS2 Gene

UTS2 (Urotensin 2) is a Protein Coding gene. Diseases associated with UTS2 include Portal Hypertension and Congenital Heart Disease. Among its related pathways are Peptide ligand-binding receptors and p70S6K Signaling. GO annotations related to this gene include receptor binding and hormone activity.

UniProtKB/Swiss-Prot for UTS2 Gene

  • Highly potent vasoconstrictor.

Tocris Summary for UTS2 Gene

  • The urotensin-II (UT) receptor is a Gq/11-protein-coupled receptor that mediates complex hemodynamic effects and influences neuromuscular physiology. The UT receptor displays greatest expression levels in the peripheral vasculature, heart and kidney.

Gene Wiki entry for UTS2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTS2 Gene

Genomics for UTS2 Gene

Regulatory Elements for UTS2 Gene

Enhancers for UTS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UTS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for UTS2 Gene

7,843,083 bp from pter
7,913,610 bp from pter
70,528 bases
Minus strand

Genomic View for UTS2 Gene

Genes around UTS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTS2 Gene

Proteins for UTS2 Gene

  • Protein details for UTS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5H8X7
    • Q6UXF6
    • Q9UKP7

    Protein attributes for UTS2 Gene

    124 amino acids
    Molecular mass:
    14296 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UTS2 Gene


neXtProt entry for UTS2 Gene

Proteomics data for UTS2 Gene at MOPED

Post-translational modifications for UTS2 Gene

No Post-translational modifications

Other Protein References for UTS2 Gene

No data available for DME Specific Peptides for UTS2 Gene

Domains & Families for UTS2 Gene

Gene Families for UTS2 Gene

Protein Domains for UTS2 Gene


Suggested Antigen Peptide Sequences for UTS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the urotensin-2 family.
  • Belongs to the urotensin-2 family.
genes like me logo Genes that share domains with UTS2: view

Function for UTS2 Gene

Molecular function for UTS2 Gene

UniProtKB/Swiss-Prot Function:
Highly potent vasoconstrictor.
genes like me logo Genes that share phenotypes with UTS2: view

Animal Models for UTS2 Gene

MGI Knock Outs for UTS2:

Animal Model Products

  • Taconic Biosciences Mouse Models for UTS2

miRNA for UTS2 Gene

miRTarBase miRNAs that target UTS2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UTS2 Gene

Localization for UTS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTS2 Gene


Subcellular locations from

Jensen Localization Image for UTS2 Gene COMPARTMENTS Subcellular localization image for UTS2 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for UTS2 Gene

Pathways & Interactions for UTS2 Gene

genes like me logo Genes that share pathways with UTS2: view

Gene Ontology (GO) - Biological Process for UTS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0003105 negative regulation of glomerular filtration IEA --
GO:0006936 muscle contraction TAS 10499587
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0007268 synaptic transmission TAS 10499587
genes like me logo Genes that share ontologies with UTS2: view

No data available for SIGNOR curated interactions for UTS2 Gene

Drugs & Compounds for UTS2 Gene

(18) Drugs for UTS2 Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BIM 23127 Pharma Antagonist NMB receptor antagonist. Also U-II receptor antagonist 0

(20) Additional Compounds for UTS2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-AC 7954 hydrochloride
UFP 803
Urotensin II (human)

(5) Tocris Compounds for UTS2 Gene

Compound Action Cas Number
(+-)-AC 7954 hydrochloride Non-peptide UT receptor agonist 477313-09-0
[Orn5]-URP Urotensin-II (UT) receptor antagonist 782485-03-4
BIM 23127 NMB receptor antagonist. Also U-II receptor antagonist 160161-61-5
UFP 803 Urotensin-II (UT) antagonist 879497-82-2
Urotensin II (human) Endogenous vasoactive agonist for the UT receptor 251293-28-4
genes like me logo Genes that share compounds with UTS2: view

Transcripts for UTS2 Gene

Unigene Clusters for UTS2 Gene

Urotensin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UTS2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2: -

Relevant External Links for UTS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UTS2 Gene

mRNA expression in normal human tissues for UTS2 Gene

mRNA differential expression in normal tissues according to GTEx for UTS2 Gene

This gene is overexpressed in Whole Blood (x11.3), Brain - Spinal cord (cervical c-1) (x9.2), Adrenal Gland (x6.1), and Brain - Hypothalamus (x5.6).

Protein differential expression in normal tissues from HIPED for UTS2 Gene

This gene is overexpressed in Stomach (10.0) and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UTS2 Gene

SOURCE GeneReport for Unigene cluster for UTS2 Gene Hs.715862

mRNA Expression by UniProt/SwissProt for UTS2 Gene

Tissue specificity: Brain specific.
genes like me logo Genes that share expression patterns with UTS2: view

Protein tissue co-expression partners for UTS2 Gene

Primer Products

Orthologs for UTS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UTS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UTS2 35
  • 81.57 (n)
  • 71.54 (a)
(Canis familiaris)
Mammalia UTS2 35
  • 76.15 (n)
  • 64.23 (a)
(Mus musculus)
Mammalia Uts2 35
  • 65.57 (n)
  • 50.82 (a)
Uts2 16
Uts2 36
  • 41 (a)
(Rattus norvegicus)
Mammalia Uts2 35
  • 67.76 (n)
  • 50.82 (a)
(Monodelphis domestica)
Mammalia UTS2 36
  • 42 (a)
(Ornithorhynchus anatinus)
Mammalia UTS2 36
  • 43 (a)
(Pan troglodytes)
Mammalia UTS2 36
  • 70 (a)
(Gallus gallus)
Aves UTS2 36
  • 40 (a)
Species with no ortholog for UTS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UTS2 Gene

Gene Tree for UTS2 (if available)
Gene Tree for UTS2 (if available)

Paralogs for UTS2 Gene

No data available for Paralogs for UTS2 Gene

Variants for UTS2 Gene

Sequence variations from dbSNP and Humsavar for UTS2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2890565 - 7,849,677(-) CTCAA(A/G)TACCA reference, missense
rs34305100 - 7,852,969(+) ATCCT(A/G)TGAAA intron-variant, reference, missense
rs106968 -- 7,914,484(-) CCAAC(C/G)TGTTA upstream-variant-2KB
rs129818 -- 7,874,767(-) tcccc(G/T)gacac intron-variant
rs228636 -- 7,857,497(+) GAGCT(C/T)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UTS2 Gene

Variant ID Type Subtype PubMed ID
nsv870846 CNV Loss 21882294
esv2660700 CNV Deletion 23128226

Variation tolerance for UTS2 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.90; 91.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTS2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTS2 Gene

Disorders for UTS2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for UTS2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
portal hypertension
  • hypertension, portal
congenital heart disease
  • congenital anomaly of heart
liver cirrhosis
  • cirrhosis
hepatic vascular disease
  • vascular disorder of liver
hypertension, essential
  • hypertension, essential 3
- elite association - COSMIC cancer census association via MalaCards
Search UTS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UTS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with UTS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UTS2 Gene

Publications for UTS2 Gene

  1. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. (PMID: 9861051) Coulouarn Y. … Vaudry H. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23 67
  2. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. (PMID: 10499587) Ames R.S. … Douglas S.A. (Nature 1999) 2 3 23
  3. Increased plasma levels of endothelin-1 and urotensin-II in patients with coronary heart disease. (PMID: 20339975) Chai S.B. … Tang C.S. (Heart Vessels 2010) 3 23
  4. Increased expression of urotensin II and GPR14 in patients with cirrhosis and portal hypertension. (PMID: 20428787) Liu D. … Wang Y. (Int. J. Mol. Med. 2010) 3 23
  5. Urotensin II induces transactivation of the epidermal growth factor receptor via transient oxidation of SHP-2 in the rat renal tubular cell line NRK-52E. (PMID: 19326266) Sue Y.M. … Chen T.H. (Growth Factors 2009) 3 23

Products for UTS2 Gene

Sources for UTS2 Gene