UTS2 Gene

Aliases
for UTS2 gene

Previous GC identifers: GC01M007485 GC01M007716 GC01M007617 GC01M007841 GC01M007055

Summaries
for UTS2 gene

Genomic Views
for UTS2 gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_021937.19  

SwitchGear Promoter luciferase reporter plasmid: UTS2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UTS2

UTS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M007904:  view genomic region     (about GC identifiers)

Proteins
for UTS2 gene

Explore the universe of human proteins at neXtProt for UTS2: NX_O95399

UTS2 Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for UTS2
	GenScript Custom Purified and Recombinant Proteins Services for UTS2
	Novus Biologicals UTS2 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for UTS2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for UTS2
	GenScript Custom Superior Antibodies Services for UTS2
	Search for Antibodies for UTS2 at Abcam
	Uscn Antibodies for UTS2
	Search ThermoFisher Antibodies for UTS2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for UTS2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for UTS2

Protein Domains /
Families
for UTS2 gene

ProtoNet protein and cluster: O95399

Function
for UTS2 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UTS2
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate UTS2:
		hsa-miR-607 hsa-miR-376c hsa-miR-877
		SwitchGear 3'UTR luciferase reporter plasmid: UTS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UTS2 (see all 7) OriGene shRNA RFP: UTS2 OriGene siRNA: UTS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UTS2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for UTS2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UTS2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UTS2 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: UTS2 (NM_018949)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for UTS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTS2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for UTS2
		Search LifeMap BioReagents cell lines for UTS2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTS2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for UTS2 gene

	Super-pathway	contained gene-specific pathways
1	Apoptotic Pathways in Synovial Fibroblasts	8/14 pathways (see all 14) Apoptotic Pathways in Synovial Fibroblasts 1.00 ERK5 Signaling 0.61 p53 Mediated Apoptosis 0.84 eIF2 Pathway 0.60 Mitochondrial Apoptosis 0.73 Rac1 Pathway 0.58 Telomerase Components in Cell Signaling 0.72 Nuclear Receptor Activation by Vitamin-A 0.57
2	GPCR Pathway	GPCR Pathway 1.00 Estrogen Pathway 0.55 Ras Pathway 0.62 Pancreatic Adenocarcinoma 0.55 Breast Cancer Regulation by Stathmin1 0.58 Paxillin Interactions 0.53 NFAT in Immune Response 0.58
3	Rho Family GTPases	Rho Family GTPases 1.00 MAPK Signaling 0.51 ERK Signaling 0.61 ILK Signaling 0.45 Molecular Mechanisms of Cancer 0.51
4	TGF-Beta Pathway	TGF-Beta Pathway 1.00 JAK-STAT Pathway 0.57 MAPK Family Pathway 0.60 JNK Pathway 0.50
5	Nanog in Mammalian ESC Pluripotency	Nanog in Mammalian ESC Pluripotency 1.00 14-3-3 Induced Intracellular Signaling 0.59 GSK3 Signaling 0.61 eNOS Signaling 0.48

5/55 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UTS2

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

5/8        Reactome Pathways for UTS2

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

Drugs & Compounds
for UTS2 gene

Transcripts
for UTS2 gene

Expression
for UTS2 gene

UTS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAACCATTA

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Ventral/hypothalamic-like neurons (Generation of midbra...)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UTS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UTS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UTS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UTS2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTS2

Orthologs
for UTS2 gene

Paralogs
for UTS2 gene

Genomic Variants
for UTS2 gene

10/185 NCBI SNPs in UTS2 are shown (see all 185)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs766584511,2	F,	--	7907226(+)	ATTCTC/TGTGCC	2	--	ds5001		1		WA	118
rs1500753381,2		--	7907301(+)	TGGTAA/GAGACA	2	--	ds5001		0	--	--	--	--
rs2286801,2	C,F,A,H,	--	7907321(+)	CATGTT/CCCCAG	2	--	ds5001		11		WA NA CSA EA	374
rs1162258741,2	F,	--	7907468(+)	AGGACA/GTCATA	2	--	ds5001		1		WA	118
rs1434406821,2	C,	--	7907620(+)	AAGAA-/TAAT           TAATT	2	--	ds5001		0	--	--	--	--
rs23075501,2	C	--	7907626(+)	AATTAATTA/-           TAAAT	2	--	ds5001		5		EU NA EA	344
rs2002660061,2	C	--	7907627(+)	AATTAA/TAAATT	2	--	ds5001		0	--	--	--	--
rs1128206911,2	C,	--	7907805(+)	CTGACT/-TAACA	2	--	ut31		1		CSA	2
rs1503894161,2	C,F	--	7907918(+)	GTTAGG/TATCTT	4	T P	mis1		2		NA EU	5865
rs1410214221,2	C,F,	--	7907931(+)	CCAGAG/TAAATC	4	L F	mis1		1		NA	4546

HapMap Linkage Disequilibrium report for UTS2 (7903143 - 7913572 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for UTS2: --
Human Gene Mutation Database (HGMD): UTS2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UTS2

DNA2.0 Custom Variant and Variant Library Synthesis for UTS2

Disorders / Diseases
for UTS2 gene

20/45 diseases for UTS2

10/41 Novoseek disease relationships for UTS2 gene (see all 41)    About this table

Publications
for UTS2 gene

PubMed articles for UTS2 gene, integrated from 9 sources (see all 277): (articles sorted by number of sources associating them with UTS2)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. (PubMed id 9861051)^{1, 2, 3, 9} Coulouarn Y.... Vaudry H. (1998)
2. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. (PubMed id 10499587)^{1, 2, 3, 9} Ames R.S....Douglas S.A. (1999)
3. Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese. (PubMed id 15476949)^{1, 4, 9} Suzuki S....Oka Y. (2004)
4. Role of urotensin II gene in genetic susceptibility to Type 2 diabetes mellitus in Japanese subjects. (PubMed id 12830381)^{1, 4, 9} Wenyi Z....Oka Y. (2003)
5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
8. [The role of urotensin II gene in the genetic susceptibility to type 2 diabetes in Chinese population] (PubMed id 12509909)^{1, 4} Zhu F....Luo B. (2002)
9. [The association of two single nucleotide polymorphisms in PRKCZ and UTS2 respectively with type 2 diabetes in Han people of northern China] (PubMed id 12905622)^{1, 4} Sun H.X....Fang F.D. (2002)
10. Differential effect of urotensin II on vascular tone in normal subjects and patients with chronic heart failure. (PubMed id 15007012)^{1, 9} Lim M....Krum H. (2004)

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for UTS2 gene