Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UTP6 Gene

Aliases for UTP6 Gene

  • UTP6, Small Subunit (SSU) Processome Component, Homolog (Yeast) 2 3
  • Hepatocellular Carcinoma Associated Antigen 66 2 3
  • Hepatocellular Carcinoma-Associated Antigen 66 3 4
  • Multiple Hat Domains Protein 3 4
  • C17orf40 3 4
  • HCA66 3 4
  • Chromosome 17 Open Reading Frame 40 2
  • MHAT 4

External Ids for UTP6 Gene

Previous HGNC Symbols for UTP6 Gene

  • C17orf40

Previous GeneCards Identifiers for UTP6 Gene

  • GC17M027216
  • GC17M030187
  • GC17M026401

Summaries for UTP6 Gene

GeneCards Summary for UTP6 Gene

UTP6 (UTP6, Small Subunit (SSU) Processome Component, Homolog (Yeast)) is a Protein Coding gene. Diseases associated with UTP6 include deep keratitis and interstitial keratitis. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include snoRNA binding.

UniProtKB/Swiss-Prot for UTP6 Gene

  • Involved in nucleolar processing of pre-18S ribosomal RNA.

Gene Wiki entry for UTP6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP6 Gene

Genomics for UTP6 Gene

Regulatory Elements for UTP6 Gene

Transcription factor binding sites by QIAGEN in the UTP6 gene promoter:

Genomic Location for UTP6 Gene

Chromosome:
17
Start:
31,860,899 bp from pter
End:
31,901,765 bp from pter
Size:
40,867 bases
Orientation:
Minus strand

Genomic View for UTP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for UTP6 Gene

Proteins for UTP6 Gene

  • Protein details for UTP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYH9-UTP6_HUMAN
    Recommended name:
    U3 small nucleolar RNA-associated protein 6 homolog
    Protein Accession:
    Q9NYH9
    Secondary Accessions:
    • Q8IX96
    • Q96BL2
    • Q9NQ91

    Protein attributes for UTP6 Gene

    Size:
    597 amino acids
    Molecular mass:
    70194 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UTP6 Gene

Proteomics data for UTP6 Gene at MOPED

Post-translational modifications for UTP6 Gene

  • Ubiquitination at Lys 180, Lys 295, Lys 463, Lys 479, Lys 498, and Lys 575
  • Modification sites at PhosphoSitePlus

Other Protein References for UTP6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for UTP6 Gene

Domains & Families for UTP6 Gene

Suggested Antigen Peptide Sequences for UTP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYH9

UniProtKB/Swiss-Prot:

UTP6_HUMAN :
  • Belongs to the UTP6 family.
  • Contains 5 HAT repeats.
Family:
  • Belongs to the UTP6 family.
Similarity:
  • Contains 5 HAT repeats.
genes like me logo Genes that share domains with UTP6: view

No data available for Gene Families for UTP6 Gene

Function for UTP6 Gene

Molecular function for UTP6 Gene

UniProtKB/Swiss-Prot Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.

Gene Ontology (GO) - Molecular Function for UTP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030515 snoRNA binding IBA --
genes like me logo Genes that share ontologies with UTP6: view
genes like me logo Genes that share phenotypes with UTP6: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UTP6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP6 Gene

Localization for UTP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP6 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UTP6 Gene COMPARTMENTS Subcellular localization image for UTP6 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for UTP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005730 nucleolus IDA --
GO:0032040 small-subunit processome IBA --
GO:0034388 Pwp2p-containing subcomplex of 90S preribosome IBA --
genes like me logo Genes that share ontologies with UTP6: view

Pathways & Interactions for UTP6 Gene

genes like me logo Genes that share pathways with UTP6: view

Pathways by source for UTP6 Gene

1 KEGG pathway for UTP6 Gene

Gene Ontology (GO) - Biological Process for UTP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006396 RNA processing --
genes like me logo Genes that share ontologies with UTP6: view

No data available for SIGNOR curated interactions for UTP6 Gene

Drugs & Compounds for UTP6 Gene

No Compound Related Data Available

Transcripts for UTP6 Gene

Unigene Clusters for UTP6 Gene

UTP6, small subunit (SSU) processome component, homolog (yeast):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UTP6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTP6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - - - -
SP2: - - -
SP3: - - - - -
SP4:
SP5: -
SP6:
SP7: -

ExUns: 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for UTP6 Gene

GeneLoc Exon Structure for
UTP6
ECgene alternative splicing isoforms for
UTP6

Expression for UTP6 Gene

mRNA expression in normal human tissues for UTP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UTP6 Gene

This gene is overexpressed in Bone (15.0), Peripheral blood mononuclear cells (12.3), Blymphocyte (8.4), and CD8 Tcells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UTP6 Gene



SOURCE GeneReport for Unigene cluster for UTP6 Gene Hs.589862

genes like me logo Genes that share expression patterns with UTP6: view

Protein tissue co-expression partners for UTP6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UTP6 Gene

Orthologs for UTP6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UTP6 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Utp6 35
  • 85.35 (n)
  • 86.24 (a)
Utp6 16
Utp6 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UTP6 35
  • 99.42 (n)
  • 99.23 (a)
UTP6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Utp6 35
  • 81.64 (n)
  • 80.03 (a)
cow
(Bos Taurus)
Mammalia UTP6 36
  • 75 (a)
OneToOne
UTP6 35
  • 81.57 (n)
  • 74.87 (a)
dog
(Canis familiaris)
Mammalia UTP6 36
  • 89 (a)
OneToOne
UTP6 35
  • 89.34 (n)
  • 89.61 (a)
oppossum
(Monodelphis domestica)
Mammalia UTP6 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UTP6 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves UTP6 36
  • 66 (a)
OneToOne
UTP6 35
  • 69.29 (n)
  • 66.19 (a)
lizard
(Anolis carolinensis)
Reptilia UTP6 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1163 35
utp6 35
  • 60.13 (n)
  • 53.1 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53963 35
zebrafish
(Danio rerio)
Actinopterygii utp6 36
  • 53 (a)
OneToOne
zgc55648 35
utp6 35
  • 59.09 (n)
  • 53.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7246 36
  • 25 (a)
OneToOne
CG7246 35
  • 40.66 (n)
  • 28.8 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008427 35
  • 41.14 (n)
  • 28.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP6 36
  • 23 (a)
OneToOne
UTP6 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G28200 35
  • 43.49 (n)
  • 29.95 (a)
rice
(Oryza sativa)
Liliopsida Os02g0103900 35
  • 43.54 (n)
  • 32.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5527 36
  • 37 (a)
OneToOne
Species with no ortholog for UTP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UTP6 Gene

ENSEMBL:
Gene Tree for UTP6 (if available)
TreeFam:
Gene Tree for UTP6 (if available)

Paralogs for UTP6 Gene

Pseudogenes.org Pseudogenes for UTP6 Gene

genes like me logo Genes that share paralogs with UTP6: view

No data available for Paralogs for UTP6 Gene

Variants for UTP6 Gene

Sequence variations from dbSNP and Humsavar for UTP6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs739799 -- 31,862,931(+) CTTGA(C/T)CTGGG downstream-variant-500B
rs739800 -- 31,863,064(+) CAAAC(A/T)GAGCA downstream-variant-500B
rs886223 -- 31,902,858(+) GCCTT(G/T)CATTT upstream-variant-2KB
rs886224 -- 31,902,883(+) ACATT(C/T)TACCC upstream-variant-2KB
rs1016995 -- 31,878,111(+) AAACA(C/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UTP6 Gene

Variant ID Type Subtype PubMed ID
dgv944e1 CNV Complex 17122850
nsv908065 CNV Loss 21882294

Variation tolerance for UTP6 Gene

Residual Variation Intolerance Score: 70.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.94; 93.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTP6 Gene

HapMap Linkage Disequilibrium report
UTP6
Human Gene Mutation Database (HGMD)
UTP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTP6 Gene

Disorders for UTP6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for UTP6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
deep keratitis
  • interstitial and deep keratitis
interstitial keratitis
congenital syphilis
  • syphilis congenital
- elite association
Search UTP6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UTP6

Genetic Association Database (GAD)
UTP6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTP6
genes like me logo Genes that share disorders with UTP6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UTP6 Gene

Publications for UTP6 Gene

  1. Positive regulation of apoptosis by HCA66, a new Apaf-1 interacting protein, and its putative role in the physiopathology of NF1 microdeletion syndrome patients. (PMID: 17380155) Piddubnyak V. … Poyet J.L. (Cell Death Differ. 2007) 23 67
  2. Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval. (PMID: 16138909) Venturin M. … Riva P. (Ann. Hum. Genet. 2005) 2 67
  3. A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions. (PMID: 10843809) Jenne D.E. … Thiel G. (Genomics 2000) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 67

Products for UTP6 Gene

Sources for UTP6 Gene

Back to Top

Content