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Aliases for UTP3 Gene

Aliases for UTP3 Gene

  • UTP3, Small Subunit Processome Component Homolog (S. Cerevisiae) 2 3
  • UTP3, Small Subunit (SSU) Processome Component, Homolog (S. Cerevisiae) 2 5
  • Charged Amino Acid-Rich Leucine Zipper 1 3 4
  • Disrupter Of Silencing SAS10 3 4
  • Disrupter Of Silencing 10 2 3
  • UTP3 Homolog 3 4
  • CRLZ1 3 4
  • SAS10 3 4
  • CRL1 3 4
  • Charged Amino Acid Rich Leucine Zipper 1 Homolog 3

External Ids for UTP3 Gene

Previous GeneCards Identifiers for UTP3 Gene

  • GC04P071775
  • GC04P071554
  • GC04P067358

Summaries for UTP3 Gene

GeneCards Summary for UTP3 Gene

UTP3 (UTP3, Small Subunit Processome Component Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with UTP3 include common bile duct disease. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for UTP3 Gene

  • Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity).

Gene Wiki entry for UTP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP3 Gene

Genomics for UTP3 Gene

Regulatory Elements for UTP3 Gene

Promoters for UTP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UTP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for UTP3 Gene

Chromosome:
4
Start:
70,688,479 bp from pter
End:
70,690,551 bp from pter
Size:
2,073 bases
Orientation:
Plus strand

Genomic View for UTP3 Gene

Genes around UTP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP3 Gene

Proteins for UTP3 Gene

  • Protein details for UTP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQZ2-SAS10_HUMAN
    Recommended name:
    Something about silencing protein 10
    Protein Accession:
    Q9NQZ2
    Secondary Accessions:
    • Q6FI82

    Protein attributes for UTP3 Gene

    Size:
    479 amino acids
    Molecular mass:
    54558 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UTP3 Gene

Proteomics data for UTP3 Gene at MOPED

Post-translational modifications for UTP3 Gene

Other Protein References for UTP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UTP3 Gene

Domains & Families for UTP3 Gene

Protein Domains for UTP3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UTP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQZ2

UniProtKB/Swiss-Prot:

SAS10_HUMAN :
  • Belongs to the SAS10 family.
Family:
  • Belongs to the SAS10 family.
genes like me logo Genes that share domains with UTP3: view

No data available for Gene Families for UTP3 Gene

Function for UTP3 Gene

Molecular function for UTP3 Gene

UniProtKB/Swiss-Prot Function:
Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity).

Gene Ontology (GO) - Molecular Function for UTP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with UTP3: view
genes like me logo Genes that share phenotypes with UTP3: view

Animal Model Products

miRNA for UTP3 Gene

miRTarBase miRNAs that target UTP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP3 Gene

Localization for UTP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UTP3 Gene COMPARTMENTS Subcellular localization image for UTP3 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for UTP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032040 small-subunit processome IBA --
genes like me logo Genes that share ontologies with UTP3: view

Pathways & Interactions for UTP3 Gene

genes like me logo Genes that share pathways with UTP3: view

Gene Ontology (GO) - Biological Process for UTP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007420 brain development IEA,ISS --
genes like me logo Genes that share ontologies with UTP3: view

No data available for SIGNOR curated interactions for UTP3 Gene

Drugs & Compounds for UTP3 Gene

No Compound Related Data Available

Transcripts for UTP3 Gene

mRNA/cDNA for UTP3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(126) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UTP3 Gene

UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTP3 Gene

No ASD Table

Relevant External Links for UTP3 Gene

GeneLoc Exon Structure for
UTP3
ECgene alternative splicing isoforms for
UTP3

Expression for UTP3 Gene

mRNA expression in normal human tissues for UTP3 Gene

Protein differential expression in normal tissues from HIPED for UTP3 Gene

This gene is overexpressed in Adrenal (14.3), Peripheral blood mononuclear cells (11.2), Lung (8.5), and CD8 Tcells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UTP3 Gene



SOURCE GeneReport for Unigene cluster for UTP3 Gene Hs.322901

genes like me logo Genes that share expression patterns with UTP3: view

Protein tissue co-expression partners for UTP3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UTP3 Gene

Orthologs for UTP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UTP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTP3 35
  • 99.65 (n)
  • 99.58 (a)
UTP3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UTP3 36
  • 89 (a)
OneToOne
UTP3 35
  • 88.06 (n)
  • 88.14 (a)
dog
(Canis familiaris)
Mammalia UTP3 35
  • 87.18 (n)
  • 87.82 (a)
UTP3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Utp3 16
Utp3 36
  • 88 (a)
OneToOne
Utp3 35
  • 82.87 (n)
  • 84.86 (a)
oppossum
(Monodelphis domestica)
Mammalia UTP3 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UTP3 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Utp3 35
  • 82.41 (n)
  • 84.04 (a)
chicken
(Gallus gallus)
Aves UTP3 36
  • 51 (a)
OneToOne
UTP3 35
  • 60.36 (n)
  • 55.01 (a)
lizard
(Anolis carolinensis)
Reptilia UTP3 36
  • 53 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2574 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7619 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5012 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17306 35
utp3 35
  • 57.06 (n)
  • 53.4 (a)
utp3 36
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002960 35
  • 46.7 (n)
  • 36.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sas10 35
  • 47.48 (n)
  • 42.73 (a)
Sas10 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAS10 36
  • 20 (a)
OneToOne
SAS10 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5711 36
  • 34 (a)
OneToOne
Species with no ortholog for UTP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UTP3 Gene

ENSEMBL:
Gene Tree for UTP3 (if available)
TreeFam:
Gene Tree for UTP3 (if available)

Paralogs for UTP3 Gene

No data available for Paralogs for UTP3 Gene

Variants for UTP3 Gene

Sequence variations from dbSNP and Humsavar for UTP3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs16845385 - 70,688,745(+) TCCCA(C/T)GCTCA reference, missense
rs3733488 -- 70,688,558(-) CACCG(A/G)AGTTT utr-variant-5-prime
rs17735360 -- 70,688,529(+) GAAAT(G/T)CCAGT utr-variant-5-prime
rs34648105 -- 70,689,790(+) TTTGA(A/T)GAAAA reference, missense
rs35275699 -- 70,690,436(+) TCTTT(-/G)GACAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UTP3 Gene

Variant ID Type Subtype PubMed ID
nsv829965 CNV Gain 17160897

Variation tolerance for UTP3 Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTP3 Gene

HapMap Linkage Disequilibrium report
UTP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTP3 Gene

Disorders for UTP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UTP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
common bile duct disease
  • common bile duct diseases
- elite association - COSMIC cancer census association via MalaCards
Search UTP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UTP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTP3
genes like me logo Genes that share disorders with UTP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UTP3 Gene

Publications for UTP3 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. ATR checkpoint kinase and CRL1I^TRCP collaborate to degrade ASF1a and thus repress genes overlapping with clusters of stalled replication forks. (PMID: 24700029) Im J.S. … Dutta A. (Genes Dev. 2014) 3

Products for UTP3 Gene

Sources for UTP3 Gene

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