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Aliases for UTP3 Gene

Aliases for UTP3 Gene

  • UTP3, Small Subunit Processome Component Homolog (S. Cerevisiae) 2 3 5
  • Charged Amino Acid-Rich Leucine Zipper 1 3 4
  • Disrupter Of Silencing SAS10 3 4
  • Disrupter Of Silencing 10 2 3
  • UTP3 Homolog 3 4
  • CRLZ1 3 4
  • SAS10 3 4
  • CRL1 3 4
  • UTP3, Small Subunit (SSU) Processome Component, Homolog (S. Cerevisiae) 2
  • Charged Amino Acid Rich Leucine Zipper 1 Homolog 3
  • Something About Silencing Protein 10 3

External Ids for UTP3 Gene

Previous GeneCards Identifiers for UTP3 Gene

  • GC04P071775
  • GC04P071554
  • GC04P067358

Summaries for UTP3 Gene

GeneCards Summary for UTP3 Gene

UTP3 (UTP3, Small Subunit Processome Component Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with UTP3 include Common Bile Duct Disease. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for UTP3 Gene

  • Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity).

Gene Wiki entry for UTP3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP3 Gene

Genomics for UTP3 Gene

Regulatory Elements for UTP3 Gene

Enhancers for UTP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G070836 1.1 ENCODE 21.2 +150.3 150255 3.8 HDGF ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 UTP3 JCHAIN RUFY3 DCK GC04P070840 PIR34937
GH04G070733 1.4 Ensembl ENCODE dbSUPER 11.2 +47.2 47203 4.8 PKNOX1 WRNIP1 RAD21 RARA YY1 EGR1 SCRT2 RELB ETV6 IKZF2 RUFY3 RNU6-784P RNU6-520P UTP3 JCHAIN PIR34937 ENSG00000272986
GH04G070901 1.5 FANTOM5 ENCODE 10.3 +214.6 214555 3.0 HNRNPUL1 PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 MOB1B DCK GRSF1 UTP3 JCHAIN
GH04G070687 1.2 ENCODE 11.4 +0.1 90 3.0 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC UTP3 GC04P070702
GH04G071003 1 Ensembl ENCODE 11 +317.1 317122 4.7 CTCF PKNOX1 MXI1 RAD21 RELA ZNF316 CBX5 EED RELB IKZF2 UTP3 JCHAIN DCK RUFY3 GC04M071034
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UTP3 on UCSC Golden Path with GeneCards custom track

Promoters for UTP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000169007 21 2201 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for UTP3 Gene

Chromosome:
4
Start:
70,688,479 bp from pter
End:
70,690,551 bp from pter
Size:
2,073 bases
Orientation:
Plus strand

Genomic View for UTP3 Gene

Genes around UTP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP3 Gene

Proteins for UTP3 Gene

  • Protein details for UTP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQZ2-SAS10_HUMAN
    Recommended name:
    Something about silencing protein 10
    Protein Accession:
    Q9NQZ2
    Secondary Accessions:
    • Q6FI82

    Protein attributes for UTP3 Gene

    Size:
    479 amino acids
    Molecular mass:
    54558 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UTP3 Gene

Post-translational modifications for UTP3 Gene

Other Protein References for UTP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UTP3 Gene

Domains & Families for UTP3 Gene

Protein Domains for UTP3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UTP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQZ2

UniProtKB/Swiss-Prot:

SAS10_HUMAN :
  • Belongs to the SAS10 family.
Family:
  • Belongs to the SAS10 family.
genes like me logo Genes that share domains with UTP3: view

No data available for Gene Families for UTP3 Gene

Function for UTP3 Gene

Molecular function for UTP3 Gene

UniProtKB/Swiss-Prot Function:
Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity).

Gene Ontology (GO) - Molecular Function for UTP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with UTP3: view
genes like me logo Genes that share phenotypes with UTP3: view

Animal Model Products

miRNA for UTP3 Gene

miRTarBase miRNAs that target UTP3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP3 Gene

Localization for UTP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTP3 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for UTP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0032040 small-subunit processome IBA --
genes like me logo Genes that share ontologies with UTP3: view

Pathways & Interactions for UTP3 Gene

genes like me logo Genes that share pathways with UTP3: view

Gene Ontology (GO) - Biological Process for UTP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
GO:0007275 multicellular organism development IEA --
GO:0007420 brain development IEA,ISS --
GO:0016569 covalent chromatin modification IEA --
genes like me logo Genes that share ontologies with UTP3: view

No data available for SIGNOR curated interactions for UTP3 Gene

Transcripts for UTP3 Gene

mRNA/cDNA for UTP3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(126) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UTP3 Gene

UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTP3 Gene

No ASD Table

Relevant External Links for UTP3 Gene

GeneLoc Exon Structure for
UTP3
ECgene alternative splicing isoforms for
UTP3

Expression for UTP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UTP3 Gene

Protein differential expression in normal tissues from HIPED for UTP3 Gene

This gene is overexpressed in Adrenal (14.3), Peripheral blood mononuclear cells (11.2), Lung (8.5), and CD8 Tcells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UTP3 Gene



Protein tissue co-expression partners for UTP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UTP3 Gene:

UTP3

SOURCE GeneReport for Unigene cluster for UTP3 Gene:

Hs.322901
genes like me logo Genes that share expression patterns with UTP3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UTP3 Gene

Orthologs for UTP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UTP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTP3 34 35
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia UTP3 34 35
  • 88.06 (n)
dog
(Canis familiaris)
Mammalia UTP3 34 35
  • 87.18 (n)
mouse
(Mus musculus)
Mammalia Utp3 34 16 35
  • 82.87 (n)
rat
(Rattus norvegicus)
Mammalia Utp3 34
  • 82.41 (n)
oppossum
(Monodelphis domestica)
Mammalia UTP3 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UTP3 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves UTP3 34 35
  • 60.36 (n)
lizard
(Anolis carolinensis)
Reptilia UTP3 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7619 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.2574 34
zebrafish
(Danio rerio)
Actinopterygii utp3 34 35
  • 57.06 (n)
Dr.17306 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5012 34
fruit fly
(Drosophila melanogaster)
Insecta Sas10 34 35
  • 47.48 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002960 34
  • 46.7 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAS10 35 37
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5711 35
  • 34 (a)
OneToOne
Species where no ortholog for UTP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UTP3 Gene

ENSEMBL:
Gene Tree for UTP3 (if available)
TreeFam:
Gene Tree for UTP3 (if available)

Paralogs for UTP3 Gene

No data available for Paralogs for UTP3 Gene

Variants for UTP3 Gene

Sequence variations from dbSNP and Humsavar for UTP3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1001791571 -- 70,686,531(+) AGCAT(A/C)GATGT intron-variant, upstream-variant-2KB
rs1001866855 -- 70,686,869(+) AAAAA(A/T)TTCAA downstream-variant-500B, upstream-variant-2KB
rs1002459236 -- 70,689,549(+) AGTCC(C/T)AGCAC reference, missense
rs1003537900 -- 70,688,307(+) GCACT(C/G)GAGAG upstream-variant-2KB
rs1004188610 -- 70,690,441(+) TGACA(A/G)TTATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UTP3 Gene

Variant ID Type Subtype PubMed ID
esv3600939 CNV gain 21293372
nsv1012495 CNV gain 25217958
nsv829965 CNV gain 17160897

Variation tolerance for UTP3 Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTP3 Gene

Disorders for UTP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UTP3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
common bile duct disease
  • common bile duct diseases
- elite association - COSMIC cancer census association via MalaCards
Search UTP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UTP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTP3
genes like me logo Genes that share disorders with UTP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UTP3 Gene

Publications for UTP3 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for UTP3 Gene

Sources for UTP3 Gene

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