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Aliases for UTP23 Gene

Aliases for UTP23 Gene

  • UTP23, Small Subunit Processome Component 2 3 5
  • C8orf53 3 4
  • UTP23, Small Subunit (SSU) Processome Component, Homolog (Yeast) 2
  • UTP23, Small Subunit (SSU) Processome Component, Homolog 3
  • RRNA-Processing Protein UTP23 Homolog 3
  • Chromosome 8 Open Reading Frame 53 2

External Ids for UTP23 Gene

Previous HGNC Symbols for UTP23 Gene

  • C8orf53

Previous GeneCards Identifiers for UTP23 Gene

  • GC08P117849
  • GC08P113105

Summaries for UTP23 Gene

GeneCards Summary for UTP23 Gene

UTP23 (UTP23, Small Subunit Processome Component) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include small ribosomal subunit rRNA binding.

UniProtKB/Swiss-Prot for UTP23 Gene

  • Involved in rRNA-processing and ribosome biogenesis.

Additional gene information for UTP23 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP23 Gene

Genomics for UTP23 Gene

GeneHancer (GH) Regulatory Elements for UTP23 Gene

Promoters and enhancers for UTP23 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I116765 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 565 +0.3 338 2.9 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 E2F8 UTP23 EIF3H MED30 RAD21
GH08I117519 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 25.4 +754.5 754476 2.4 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF213 E2F8 ZNF143 MED30 LOC105375716 UTP23 EIF3H EXT1 RPS10P16
GH08I116754 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 16.4 -10.9 -10938 2.1 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B EIF3H MED30 UTP23 LOC105375713
GH08I116869 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.3 +106.2 106196 5.5 HDGF PKNOX1 ATF1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 BRCA1 YY1 RAD21 RAD21-AS1 MED30 UTP23 MIR3610 GC08P116801
GH08I117618 Enhancer 0.8 ENCODE 14.9 +853.2 853196 1.6 PKNOX1 INSM2 KLF17 FEZF1 RFX5 ZEB1 ZNF366 RCOR1 ZNF548 FOS UTP23 MED30 LOC105375721 RPS10P16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UTP23 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UTP23 gene promoter:

Genomic Locations for UTP23 Gene

Genomic Locations for UTP23 Gene
chr8:116,766,503-116,849,463
(GRCh38/hg38)
Size:
82,961 bases
Orientation:
Plus strand
chr8:117,778,742-117,861,702
(GRCh37/hg19)

Genomic View for UTP23 Gene

Genes around UTP23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTP23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTP23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP23 Gene

Proteins for UTP23 Gene

  • Protein details for UTP23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRU9-UTP23_HUMAN
    Recommended name:
    rRNA-processing protein UTP23 homolog
    Protein Accession:
    Q9BRU9
    Secondary Accessions:
    • B2RE25
    • Q96NJ8

    Protein attributes for UTP23 Gene

    Size:
    249 amino acids
    Molecular mass:
    28402 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UTP23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UTP23 Gene

Post-translational modifications for UTP23 Gene

No Post-translational modifications

Other Protein References for UTP23 Gene

No data available for DME Specific Peptides for UTP23 Gene

Domains & Families for UTP23 Gene

Gene Families for UTP23 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UTP23 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UTP23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRU9

UniProtKB/Swiss-Prot:

UTP23_HUMAN :
  • Belongs to the UTP23/FCF1 family. UTP23 subfamily.
Family:
  • Belongs to the UTP23/FCF1 family. UTP23 subfamily.
genes like me logo Genes that share domains with UTP23: view

Function for UTP23 Gene

Molecular function for UTP23 Gene

UniProtKB/Swiss-Prot Function:
Involved in rRNA-processing and ribosome biogenesis.

Phenotypes From GWAS Catalog for UTP23 Gene

Gene Ontology (GO) - Molecular Function for UTP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IDA 22658674
GO:0003730 mRNA 3-UTR binding IDA 16213212
GO:0005515 protein binding IPI 25416956
GO:0048027 mRNA 5-UTR binding IDA 16213212
GO:0070181 small ribosomal subunit rRNA binding IBA --
genes like me logo Genes that share ontologies with UTP23: view
genes like me logo Genes that share phenotypes with UTP23: view

Animal Model Products

CRISPR Products

miRNA for UTP23 Gene

miRTarBase miRNAs that target UTP23

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP23 Gene

Localization for UTP23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP23 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTP23 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UTP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IBA --
GO:0032040 small-subunit processome IEA,IBA --
genes like me logo Genes that share ontologies with UTP23: view

Pathways & Interactions for UTP23 Gene

SuperPathways for UTP23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UTP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000480 endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA --
GO:0006364 rRNA processing IEA --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with UTP23: view

No data available for Pathways by source and SIGNOR curated interactions for UTP23 Gene

Drugs & Compounds for UTP23 Gene

No Compound Related Data Available

Transcripts for UTP23 Gene

Unigene Clusters for UTP23 Gene

UTP23, small subunit (SSU) processome component, homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTP23 Gene

No ASD Table

Relevant External Links for UTP23 Gene

GeneLoc Exon Structure for
UTP23
ECgene alternative splicing isoforms for
UTP23

Expression for UTP23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UTP23 Gene

Protein differential expression in normal tissues from HIPED for UTP23 Gene

This gene is overexpressed in Lung (34.3), Peripheral blood mononuclear cells (14.6), and CD8 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UTP23 Gene



Protein tissue co-expression partners for UTP23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UTP23 Gene:

UTP23

SOURCE GeneReport for Unigene cluster for UTP23 Gene:

Hs.86970

Evidence on tissue expression from TISSUES for UTP23 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with UTP23: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UTP23 Gene

Orthologs for UTP23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UTP23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTP23 33 34
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia UTP23 33 34
  • 93.52 (n)
cow
(Bos Taurus)
Mammalia UTP23 34
  • 92 (a)
OneToOne
LOC781182 33
  • 90.86 (n)
mouse
(Mus musculus)
Mammalia Utp23 33 16 34
  • 83.74 (n)
rat
(Rattus norvegicus)
Mammalia Utp23 33
  • 83.67 (n)
oppossum
(Monodelphis domestica)
Mammalia UTP23 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UTP23 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves UTP23 33 34
  • 72.12 (n)
lizard
(Anolis carolinensis)
Reptilia UTP23 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia utp23 33
  • 69.38 (n)
Str.6335 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23930 33
zebrafish
(Danio rerio)
Actinopterygii utp23 33 34
  • 62.54 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2232 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008325 33
  • 49.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17652 33 34
  • 47.44 (n)
worm
(Caenorhabditis elegans)
Secernentea C34E10.10 33 34
  • 50.58 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D01023g 33
  • 44.04 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP23 33 34 36
  • 42.42 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR011C 33
  • 41.49 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MEE21 33
  • 49 (n)
rice
(Oryza sativa)
Liliopsida Os02g0468200 33
  • 49.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10877 34
  • 43 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes utp23 33
  • 40.69 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02748 33
Species where no ortholog for UTP23 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTP23 Gene

ENSEMBL:
Gene Tree for UTP23 (if available)
TreeFam:
Gene Tree for UTP23 (if available)

Paralogs for UTP23 Gene

(1) SIMAP similar genes for UTP23 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with UTP23: view

No data available for Paralogs for UTP23 Gene

Variants for UTP23 Gene

Sequence variations from dbSNP and Humsavar for UTP23 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000294330 -- 116,765,679(+) T/G upstream_transcript_variant
rs1001256865 -- 116,773,965(+) T/A 3_prime_UTR_variant
rs1001791055 -- 116,766,797(+) C/G intron_variant
rs1001948125 -- 116,768,051(+) A/G intron_variant
rs1002044343 -- 116,774,801(+) A/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for UTP23 Gene

Variant ID Type Subtype PubMed ID
nsv824724 CNV loss 20364138
nsv831434 CNV gain 17160897

Variation tolerance for UTP23 Gene

Residual Variation Intolerance Score: 66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.11; 84.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UTP23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTP23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTP23 Gene

Disorders for UTP23 Gene

Additional Disease Information for UTP23

No disorders were found for UTP23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTP23 Gene

Publications for UTP23 Gene

  1. Utp23p is required for dissociation of snR30 small nucleolar RNP from preribosomal particles. (PMID: 22180534) Hoareau-Aveilla C … Kiss T (Nucleic acids research 2012) 2 3 58
  2. The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation. (PMID: 16769905) Bleichert F … Baserga SJ (Proceedings of the National Academy of Sciences of the United States of America 2006) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for UTP23 Gene

Sources for UTP23 Gene

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