UTP23 Gene
protein-coding GIFtS: 45
GCID: GC08P117849
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UTP23, small subunit (SSU) processome component, homolog...(Previous name: chromosome 8 open reading frame 53 )
(Previous symbol: C8orf53)
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Aliases
for UTP23 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| UTP23, Small Subunit (SSU) Processome Component, Homolog (Yeast)1 2 | | C8orf531 2 3 | | MGC145951 | | Chromosome 8 Open Reading Frame 531 | | RRNA-Processing Protein UTP23 Homolog2 |
Export aliases for UTP23 gene to outside databasesPrevious GC identifer: GC08P113105 |
Summaries
for UTP23 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UTP23_HUMAN, Q9BRU9Function: Involved in rRNA-processing and ribosome biogenesis (By similarity)
|
Genomic Views
for UTP23 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UTP23 gene promoter:
HFH-3 Max1 Sox5 Sp1 MyoD C/EBPalpha MEF-2A FOXI1 aMEF-2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for UTP23
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UTP23 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.11 Ensembl cytogenetic band: 8q24.11 HGNC cytogenetic band: 8q24.11UTP23 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P117849: view genomic region
(about GC identifiers)
Start:
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117,778,742 bp from pter |
End:
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117,861,702 bp from pter |
Size:
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82,961 bases |
Orientation:
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plus strand |
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Proteins
for UTP23 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UTP23_HUMAN, Q9BRU9 (See
protein sequence)Recommended Name: rRNA-processing protein UTP23 homolog Size: 249 amino acids; 28402 Da
Subcellular location: Nucleus, nucleolus (By similarity)
Secondary accessions: B2RE25 Q96NJ8Alternative splicing: 2 isoforms: Q9BRU9-1 Q9BRU9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for UTP23: NX_Q9BRU9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BRU9
UTP23 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115710.2
ENSEMBL proteins: ENSP00000308332 ENSP00000428455 ENSP00000429962 ENSP00000430029 ENSP00000427767 ENSP00000429384 ENSP00000430309 ENSP00000349670
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
IEA | -- |
UTP23 for ontologies About GeneDecksing
UTP23 Antibody Products:
Assay Products for UTP23: |
Protein
Domains /
Families
for UTP23 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UTP23 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BRU9ProtoNet protein and cluster: Q9BRU9 UniProtKB/Swiss-Prot: UTP23_HUMAN, Q9BRU9Similarity: Belongs to the UTP23/FCF1 family. UTP23 subfamily |
Function
for UTP23 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UTP23_HUMAN, Q9BRU9Function: Involved in rRNA-processing and ribosome biogenesis (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UTP23 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UTP23 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for UTP23 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTP23 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTP23 |
|
Pathways & Interactions
for UTP23 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UTP23
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/12 Interacting proteins for UTP23 (Q9BRU93 ENSP000003083324) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006364 | rRNA processing |
IEA | -- |
UTP23 for ontologies About GeneDecksing
|
Drugs & Compounds
for UTP23 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UTP23
Search CenterWatch for drugs/clinical trials and news about UTP23
|
Transcripts
for UTP23 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UTP23 gene: NM_032334.2 Unigene Cluster for UTP23: UTP23, small subunit (SSU) processome component, homolog (yeast) Hs.86970 [show with all ESTs]Unigene Representative Sequence: NM_03233410 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000309822(uc003yoc.3) ENST00000521703 ENST00000517814 ENST00000521071
ENST00000519443 ENST00000517820 ENST00000521974 ENST00000520733 ENST00000524128
ENST00000357148
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UTP23 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UTP23 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UTP23 (NM_032334) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UTP23 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTP23 |
Additional cDNA sequence: AK315770.1 BC005955.1 BC022441.1 19 DOTS entries: DT.440334 DT.121468877 DT.99951983 DT.97824087 DT.100775845 DT.100001297 DT.121468830 DT.91715239 DT.209021 DT.92022825 DT.97790792 DT.100778712 DT.95318862 DT.100715646 DT.101957256 DT.40252179 DT.75191889 DT.91872784 DT.91952378 24/130 AceView cDNA sequences (see all 130): BQ186975 BQ683436 BF001846 CK300049 AI301401 AI056895 BU179334 BQ679942 CR625411 BE018632 BQ680542 BM931198 BX476762 BQ897640 BQ683666 AI373246 AA767509 BU167853 CD365234 AA056028 BQ680911 BX483613 CB321992 CA950564
GeneLoc Exon Structure
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Expression
for UTP23 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UTP23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAAGAAAG
About this image
See UTP23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UTP23
SOURCE GeneReport for Unigene cluster: Hs.86970
SABiosciences Custom PCR Arrays for UTP23
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UTP23
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UTP23 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UTP23 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UTP23 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTP23 |
Orthologs
for UTP23 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UTP23 gene from 10/33 species (see all 33) About this table
ENSEMBL Gene Tree for UTP23 (if available)
TreeFam Gene Tree for UTP23 (if available) |
Paralogs
for UTP23 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for UTP23 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UTP23 (117778742 - 117861702 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UTP23: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UTP23 |
|
Disorders
/ Diseases
for UTP23 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UTP23 for disorders About GeneDecksing
1  disease for UTP23: About MalaCardsmalaria
Export disorders for UTP23 gene to outside databases
|
Publications
for UTP23 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UTP23 gene integrated from 9 sources:
(articles sorted by number of sources associating them with UTP23) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation. (PubMed id 16769905)1, 3 Bleichert F....Baserga S.J. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for UTP23 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing UTP23 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UTP23 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UTP23 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UTP23 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for UTP23 gene:
Search GeneIP for patents involving UTP23
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UTP23 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UTP23 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UTP23 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UTP23 | | | OriGene Protein Over-expression Lysate for UTP23 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UTP23 | | OriGene 3'-UTR Clone for UTP23 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UTP23 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UTP23 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UTP23 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UTP23 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UTP23 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UTP23 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UTP23 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UTP23 |
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| |  |  |  |  | | | | | | Recombinant Protein for UTP23 |
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 | | | UTP23 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTP23 |
|  |  |  | | | | ThermoFisher Antibodies for UTP23 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTP23 |
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