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Aliases for UTP23 Gene

Aliases for UTP23 Gene

  • UTP23, Small Subunit Processome Component 2 3 5
  • C8orf53 3 4
  • UTP23, Small Subunit (SSU) Processome Component, Homolog (Yeast) 2
  • UTP23, Small Subunit (SSU) Processome Component, Homolog 3
  • RRNA-Processing Protein UTP23 Homolog 3
  • Chromosome 8 Open Reading Frame 53 2

External Ids for UTP23 Gene

Previous HGNC Symbols for UTP23 Gene

  • C8orf53

Previous GeneCards Identifiers for UTP23 Gene

  • GC08P117849
  • GC08P113105

Summaries for UTP23 Gene

GeneCards Summary for UTP23 Gene

UTP23 (UTP23, Small Subunit Processome Component) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and small ribosomal subunit rRNA binding.

UniProtKB/Swiss-Prot for UTP23 Gene

  • Involved in rRNA-processing and ribosome biogenesis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP23 Gene

Genomics for UTP23 Gene

Regulatory Elements for UTP23 Gene

Enhancers for UTP23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G116765 1.1 ENCODE 15 +0.3 339 2.9 PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF766 UTP23 EIF3H RAD21
GH08G117519 1.1 ENCODE 14.2 +754.5 754477 2.4 PKNOX1 FOXA2 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF143 UTP23 EIF3H EXT1 MED30 RPS10P16
GH08G116869 1.7 FANTOM5 ENCODE dbSUPER 8.3 +106.2 106197 5.5 HDGF PKNOX1 FOXA2 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 RAD21 UTP23 RAD21-AS1 GC08P116801
GH08G117618 0.9 ENCODE 14.9 +853.2 853196 1.6 PKNOX1 INSM2 KLF17 FEZF1 ZEB1 RFX5 GATA2 ZNF366 RCOR1 ZNF548 UTP23 MED30 LOC105375721 RPS10P16
GH08G116754 1.1 ENCODE 5.9 -10.9 -10941 2.1 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 MED30 UTP23 LOC105375713
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UTP23 on UCSC Golden Path with GeneCards custom track

Promoters for UTP23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000229070 97 2001 PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF766

Genomic Location for UTP23 Gene

Chromosome:
8
Start:
116,766,503 bp from pter
End:
116,849,463 bp from pter
Size:
82,961 bases
Orientation:
Plus strand

Genomic View for UTP23 Gene

Genes around UTP23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTP23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTP23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP23 Gene

Proteins for UTP23 Gene

  • Protein details for UTP23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRU9-UTP23_HUMAN
    Recommended name:
    rRNA-processing protein UTP23 homolog
    Protein Accession:
    Q9BRU9
    Secondary Accessions:
    • B2RE25
    • Q96NJ8

    Protein attributes for UTP23 Gene

    Size:
    249 amino acids
    Molecular mass:
    28402 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UTP23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UTP23 Gene

Post-translational modifications for UTP23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UTP23 Gene

No data available for DME Specific Peptides for UTP23 Gene

Domains & Families for UTP23 Gene

Protein Domains for UTP23 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UTP23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRU9

UniProtKB/Swiss-Prot:

UTP23_HUMAN :
  • Belongs to the UTP23/FCF1 family. UTP23 subfamily.
Family:
  • Belongs to the UTP23/FCF1 family. UTP23 subfamily.
genes like me logo Genes that share domains with UTP23: view

No data available for Gene Families for UTP23 Gene

Function for UTP23 Gene

Molecular function for UTP23 Gene

UniProtKB/Swiss-Prot Function:
Involved in rRNA-processing and ribosome biogenesis.

Gene Ontology (GO) - Molecular Function for UTP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003730 mRNA 3-UTR binding IDA 16213212
GO:0005515 protein binding IPI 25416956
GO:0048027 mRNA 5-UTR binding IDA 16213212
GO:0070181 small ribosomal subunit rRNA binding IBA --
genes like me logo Genes that share ontologies with UTP23: view
genes like me logo Genes that share phenotypes with UTP23: view

Animal Model Products

CRISPR Products

miRNA for UTP23 Gene

miRTarBase miRNAs that target UTP23

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP23 Gene

Localization for UTP23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP23 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTP23 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for UTP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA,IBA --
GO:0032040 small-subunit processome IEA,IBA --
genes like me logo Genes that share ontologies with UTP23: view

Pathways & Interactions for UTP23 Gene

SuperPathways for UTP23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UTP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000480 endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA --
GO:0006364 rRNA processing IEA --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with UTP23: view

No data available for Pathways by source and SIGNOR curated interactions for UTP23 Gene

Drugs & Compounds for UTP23 Gene

No Compound Related Data Available

Transcripts for UTP23 Gene

Unigene Clusters for UTP23 Gene

UTP23, small subunit (SSU) processome component, homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTP23 Gene

No ASD Table

Relevant External Links for UTP23 Gene

GeneLoc Exon Structure for
UTP23
ECgene alternative splicing isoforms for
UTP23

Expression for UTP23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UTP23 Gene

Protein differential expression in normal tissues from HIPED for UTP23 Gene

This gene is overexpressed in Lung (34.3), Peripheral blood mononuclear cells (14.6), and CD8 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UTP23 Gene



Protein tissue co-expression partners for UTP23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UTP23 Gene:

UTP23

SOURCE GeneReport for Unigene cluster for UTP23 Gene:

Hs.86970

Evidence on tissue expression from TISSUES for UTP23 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with UTP23: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UTP23 Gene

Orthologs for UTP23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UTP23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTP23 34 35
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia UTP23 34 35
  • 93.52 (n)
cow
(Bos Taurus)
Mammalia UTP23 35
  • 92 (a)
OneToOne
LOC781182 34
  • 90.86 (n)
mouse
(Mus musculus)
Mammalia Utp23 34 16 35
  • 83.74 (n)
rat
(Rattus norvegicus)
Mammalia Utp23 34
  • 83.67 (n)
oppossum
(Monodelphis domestica)
Mammalia UTP23 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UTP23 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves UTP23 34 35
  • 72.12 (n)
lizard
(Anolis carolinensis)
Reptilia UTP23 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia utp23 34
  • 69.38 (n)
Str.6335 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23930 34
zebrafish
(Danio rerio)
Actinopterygii utp23 34 35
  • 62.54 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2232 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008325 34
  • 49.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17652 34 35
  • 47.44 (n)
worm
(Caenorhabditis elegans)
Secernentea C34E10.10 34 35
  • 50.58 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D01023g 34
  • 44.04 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP23 34 35 37
  • 42.42 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR011C 34
  • 41.49 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MEE21 34
  • 49 (n)
rice
(Oryza sativa)
Liliopsida Os02g0468200 34
  • 49.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10877 35
  • 43 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes utp23 34
  • 40.69 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02748 34
Species where no ortholog for UTP23 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTP23 Gene

ENSEMBL:
Gene Tree for UTP23 (if available)
TreeFam:
Gene Tree for UTP23 (if available)

Paralogs for UTP23 Gene

(1) SIMAP similar genes for UTP23 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with UTP23: view

No data available for Paralogs for UTP23 Gene

Variants for UTP23 Gene

Sequence variations from dbSNP and Humsavar for UTP23 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000294330 -- 116,765,679(+) GCACA(G/T)AAAAA upstream-variant-2KB
rs1001256865 -- 116,773,965(+) ACCCC(A/T)AAAAC utr-variant-3-prime
rs1001791055 -- 116,766,797(+) GTGGG(C/G)CCGGG intron-variant
rs1001948125 -- 116,768,051(+) CCCCC(A/G)TCTCT intron-variant
rs1002044343 -- 116,774,801(+) TAAGG(A/T)TATAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for UTP23 Gene

Variant ID Type Subtype PubMed ID
nsv824724 CNV loss 20364138
nsv831434 CNV gain 17160897

Variation tolerance for UTP23 Gene

Residual Variation Intolerance Score: 66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.11; 84.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTP23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTP23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTP23 Gene

Disorders for UTP23 Gene

Relevant External Links for UTP23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTP23

No disorders were found for UTP23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTP23 Gene

Publications for UTP23 Gene

  1. Utp23p is required for dissociation of snR30 small nucleolar RNP from preribosomal particles. (PMID: 22180534) Hoareau-Aveilla C. … Kiss T. (Nucleic Acids Res. 2012) 2 3 64
  2. The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation. (PMID: 16769905) Bleichert F. … Baserga S.J. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for UTP23 Gene

Sources for UTP23 Gene

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