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Aliases for UTP20 Gene

Aliases for UTP20 Gene

  • UTP20, Small Subunit Processome Component 2 3
  • UTP20 Small Subunit Processome Component 3 5
  • Down-Regulated In Metastasis Protein 3 4
  • Down Regulated In Metastasis 2 3
  • Novel Nucleolar Protein 73 3 4
  • NNP73 3 4
  • DRIM 3 4
  • UTP20, Small Subunit (SSU) Processome Component, Homolog (Yeast) 2
  • UTP20, Small Subunit (SSU) Processome Component, Homolog 3
  • UTP20 Small Subunit (SSU) Processome Component 3
  • Protein Key-1A6 4
  • 1A6/DRIM 3

External Ids for UTP20 Gene

Previous GeneCards Identifiers for UTP20 Gene

  • GC12P100198
  • GC12P101673
  • GC12P098734

Summaries for UTP20 Gene

Entrez Gene Summary for UTP20 Gene

  • UTP20 is a component of the U3 small nucleolar RNA (snoRNA) (SNORD3A; MIM 180710) protein complex (U3 snoRNP) and is involved in 18S rRNA processing (Wang et al., 2007 [PubMed 17498821]).[supplied by OMIM, Jun 2009]

GeneCards Summary for UTP20 Gene

UTP20 (UTP20, Small Subunit Processome Component) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include poly(A) RNA binding and binding.

UniProtKB/Swiss-Prot for UTP20 Gene

  • Involved in 18S pre-rRNA processing. Associates with U3 snoRNA.

Gene Wiki entry for UTP20 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP20 Gene

Genomics for UTP20 Gene

Regulatory Elements for UTP20 Gene

Enhancers for UTP20 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UTP20 on UCSC Golden Path with GeneCards custom track

Promoters for UTP20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UTP20 on UCSC Golden Path with GeneCards custom track

Genomic Location for UTP20 Gene

101,280,109 bp from pter
101,386,619 bp from pter
106,511 bases
Plus strand

Genomic View for UTP20 Gene

Genes around UTP20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTP20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTP20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP20 Gene

Proteins for UTP20 Gene

  • Protein details for UTP20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small subunit processome component 20 homolog
    Protein Accession:
    Secondary Accessions:
    • Q9H3H4

    Protein attributes for UTP20 Gene

    2785 amino acids
    Molecular mass:
    318385 Da
    Quaternary structure:
    • Interacts with FBL and PPP1R26.
    • Sequence=AAG35208.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for UTP20 Gene

Proteomics data for UTP20 Gene at MOPED

Post-translational modifications for UTP20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UTP20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UTP20 Gene

Domains & Families for UTP20 Gene

Protein Domains for UTP20 Gene


Suggested Antigen Peptide Sequences for UTP20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UTP20 family.
  • Contains 2 HEAT repeats.
  • Belongs to the UTP20 family.
  • Contains 2 HEAT repeats.
genes like me logo Genes that share domains with UTP20: view

No data available for Gene Families for UTP20 Gene

Function for UTP20 Gene

Molecular function for UTP20 Gene

UniProtKB/Swiss-Prot Function:
Involved in 18S pre-rRNA processing. Associates with U3 snoRNA.
genes like me logo Genes that share phenotypes with UTP20: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP20 Gene

Localization for UTP20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP20 Gene

Nucleus, nucleolus. Note=Colocalizes with NCL in the nucleolus.

Subcellular locations from

Jensen Localization Image for UTP20 Gene COMPARTMENTS Subcellular localization image for UTP20 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for UTP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus ISS 15590835
genes like me logo Genes that share ontologies with UTP20: view

Pathways & Interactions for UTP20 Gene

genes like me logo Genes that share pathways with UTP20: view

Pathways by source for UTP20 Gene

Gene Ontology (GO) - Biological Process for UTP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000472 endonucleolytic cleavage to generate mature 5-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS 17652137
GO:0008285 negative regulation of cell proliferation TAS 9673349
genes like me logo Genes that share ontologies with UTP20: view

No data available for SIGNOR curated interactions for UTP20 Gene

Drugs & Compounds for UTP20 Gene

No Compound Related Data Available

Transcripts for UTP20 Gene

Unigene Clusters for UTP20 Gene

UTP20, small subunit (SSU) processome component, homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UTP20 Gene

No ASD Table

Relevant External Links for UTP20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UTP20 Gene

mRNA expression in normal human tissues for UTP20 Gene

Protein differential expression in normal tissues from HIPED for UTP20 Gene

This gene is overexpressed in Stomach (16.9), Blymphocyte (10.9), and Adrenal (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UTP20 Gene

SOURCE GeneReport for Unigene cluster for UTP20 Gene Hs.295732

mRNA Expression by UniProt/SwissProt for UTP20 Gene

Tissue specificity: Expressed in appendix, brain, colon, fetal liver, heart, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus.
genes like me logo Genes that share expression patterns with UTP20: view

Protein tissue co-expression partners for UTP20 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UTP20 Gene

Orthologs for UTP20 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UTP20 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UTP20 35
  • 89.14 (n)
  • 90.18 (a)
UTP20 36
  • 90 (a)
(Canis familiaris)
Mammalia UTP20 35
  • 89.61 (n)
  • 90.35 (a)
UTP20 36
  • 90 (a)
(Mus musculus)
Mammalia Utp20 35
  • 84.25 (n)
  • 86.09 (a)
Utp20 16
Utp20 36
  • 86 (a)
(Pan troglodytes)
Mammalia UTP20 35
  • 99.25 (n)
  • 99.02 (a)
UTP20 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Utp20 35
  • 84.29 (n)
  • 86.1 (a)
(Monodelphis domestica)
Mammalia UTP20 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia UTP20 36
  • 73 (a)
(Gallus gallus)
Aves UTP20 35
  • 69.14 (n)
  • 69.67 (a)
UTP20 36
  • 69 (a)
(Anolis carolinensis)
Reptilia UTP20 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia utp20 35
  • 65.96 (n)
  • 64.46 (a)
(Danio rerio)
Actinopterygii im:7159098 35
  • 60.89 (n)
  • 58.24 (a)
wufb83c08 35
UTP20 36
  • 57 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1547 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005033 35
  • 40.84 (n)
  • 26.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4554 35
  • 42.13 (n)
  • 29.11 (a)
CG4554 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea tag-184 35
  • 42.8 (n)
  • 27.1 (a)
C56E6.9 36
  • 22 (a)
tag-184 36
  • 24 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL006W 35
  • 42.44 (n)
  • 27.12 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17425g 35
  • 43.27 (n)
  • 28.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP20 35
  • 42.3 (n)
  • 26.98 (a)
UTP20 36
  • 23 (a)
UTP20 38
bread mold
(Neurospora crassa)
Ascomycetes NCU02494 35
  • 41.19 (n)
  • 26.88 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes utp20 35
  • 43.44 (n)
  • 29.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for UTP20:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTP20 Gene

Gene Tree for UTP20 (if available)
Gene Tree for UTP20 (if available)

Paralogs for UTP20 Gene

No data available for Paralogs for UTP20 Gene

Variants for UTP20 Gene

Sequence variations from dbSNP and Humsavar for UTP20 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs4764643 - 101,299,756(+) TTTAT(C/G/T)TATAA reference, missense
rs1061436 - 101,383,218(+) AGGAA(A/C/G)AGCTC reference, missense
rs140657361 A breast cancer sample 101,352,104(+) TTGCA(A/T)ACATC reference, missense
VAR_036275 A breast cancer sample
rs2290723 - 101,286,353(-) AATCC(A/G/T)TCTGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for UTP20 Gene

Variant ID Type Subtype PubMed ID
nsv470315 CNV Gain 18288195
esv2746278 CNV Deletion 23290073
nsv527122 CNV Loss 19592680
nsv510315 CNV Loss 20534489
esv2497077 CNV Deletion 19546169
esv2152079 CNV Deletion 18987734
esv2746279 CNV Deletion 23290073
esv2663815 CNV Deletion 23128226
nsv53174 CNV Loss 16902084
nsv527505 CNV Loss 19592680

Variation tolerance for UTP20 Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.16; 80.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UTP20 Gene

Disorders for UTP20 Gene

Relevant External Links for UTP20

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UTP20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTP20 Gene

Publications for UTP20 Gene

  1. Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing. (PMID: 17498821) Wang Y. … Ke Y. (Biochim. Biophys. Acta 2007) 2 3 4 67
  2. The small-subunit processome is a ribosome assembly intermediate. (PMID: 15590835) Bernstein K.A. … Baserga S.J. (Eukaryotic Cell 2004) 2 3
  3. Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis. (PMID: 9673349) Schwirzke M. … Weidle U.H. (Anticancer Res. 1998) 2 3
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  5. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3

Products for UTP20 Gene

Sources for UTP20 Gene