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Aliases for UTP20 Gene

Aliases for UTP20 Gene

  • UTP20, Small Subunit Processome Component 2 3 5
  • Down-Regulated In Metastasis Protein 3 4
  • Down Regulated In Metastasis 2 3
  • Novel Nucleolar Protein 73 3 4
  • NNP73 3 4
  • DRIM 3 4
  • UTP20, Small Subunit (SSU) Processome Component, Homolog (Yeast) 2
  • UTP20, Small Subunit (SSU) Processome Component, Homolog 3
  • UTP20 Small Subunit (SSU) Processome Component 3
  • Small Subunit Processome Component 20 Homolog 3
  • Protein Key-1A6 4
  • 1A6/DRIM 3

External Ids for UTP20 Gene

Previous GeneCards Identifiers for UTP20 Gene

  • GC12P100198
  • GC12P101673
  • GC12P098734

Summaries for UTP20 Gene

Entrez Gene Summary for UTP20 Gene

  • UTP20 is a component of the U3 small nucleolar RNA (snoRNA) (SNORD3A; MIM 180710) protein complex (U3 snoRNP) and is involved in 18S rRNA processing (Wang et al., 2007 [PubMed 17498821]).[supplied by OMIM, Jun 2009]

GeneCards Summary for UTP20 Gene

UTP20 (UTP20, Small Subunit Processome Component) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and binding.

UniProtKB/Swiss-Prot for UTP20 Gene

  • Involved in 18S pre-rRNA processing. Associates with U3 snoRNA.

Gene Wiki entry for UTP20 Gene

Additional gene information for UTP20 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP20 Gene

Genomics for UTP20 Gene

Regulatory Elements for UTP20 Gene

Enhancers for UTP20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H102060 1.1 ENCODE 29.7 +781.6 781566 2.1 HDGF PKNOX1 FOXA2 ATF1 ARID4B SIN3A DMAP1 BRCA1 YY1 ETS1 WASHC3 UTP20 NUP37 ENSG00000257222 ST13P22 PARPBP NENFP2
GH12H101875 1.5 FANTOM5 ENCODE 21.1 +597.2 597239 4.5 HDGF ARNT ARID4B SIN3A DMAP1 ZNF207 ZNF143 SP3 ZHX2 REST DRAM1 ENSG00000257222 UTP20 CHPT1 ST13P22 NUP37 PARPBP GNPTAB PIR46358
GH12H101279 1 ENCODE 17.7 +0.1 118 1.5 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ETS1 SLC30A9 ZNF143 ATF7 ARL1 UTP20 ENSG00000257222 NUP37
GH12H101051 1.2 Ensembl ENCODE 12.9 -227.7 -227711 2.7 FEZF1 ZNF2 GLIS2 FOS SP3 TSHZ1 ZNF518A NFIL3 GLIS1 WT1 UTP20 GAS2L3 ENSG00000258007 SNX5P2
GH12H101669 1.1 Ensembl ENCODE 12.3 +390.3 390263 0.9 PKNOX1 ARNT ZSCAN4 ZSCAN9 RAD21 RUNX3 ZNF654 MCM3 CEBPB REST LOC105369936 NUP37 ENSG00000257222 CHPT1 UTP20 SYCP3 GC12P101665 ENSG00000274560
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UTP20 on UCSC Golden Path with GeneCards custom track

Promoters for UTP20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000056275 92 2000 MLX ARNT ARID4B SIN3A ZNF2 YY1 ETS1 SLC30A9 ZNF143 ATF7

Genomic Locations for UTP20 Gene

Genomic Locations for UTP20 Gene
106,511 bases
Plus strand

Genomic View for UTP20 Gene

Genes around UTP20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTP20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTP20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP20 Gene

Proteins for UTP20 Gene

  • Protein details for UTP20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small subunit processome component 20 homolog
    Protein Accession:
    Secondary Accessions:
    • Q9H3H4

    Protein attributes for UTP20 Gene

    2785 amino acids
    Molecular mass:
    318385 Da
    Quaternary structure:
    • Interacts with FBL and PPP1R26.
    • Sequence=AAG35208.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for UTP20 Gene

Post-translational modifications for UTP20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UTP20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UTP20 Gene

Domains & Families for UTP20 Gene

Gene Families for UTP20 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UTP20 Gene

Suggested Antigen Peptide Sequences for UTP20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UTP20 family.
  • Belongs to the UTP20 family.
genes like me logo Genes that share domains with UTP20: view

Function for UTP20 Gene

Molecular function for UTP20 Gene

UniProtKB/Swiss-Prot Function:
Involved in 18S pre-rRNA processing. Associates with U3 snoRNA.

Phenotypes From GWAS Catalog for UTP20 Gene

Gene Ontology (GO) - Molecular Function for UTP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 16053918
genes like me logo Genes that share ontologies with UTP20: view
genes like me logo Genes that share phenotypes with UTP20: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP20 Gene

Localization for UTP20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP20 Gene

Nucleus, nucleolus. Note=Colocalizes with NCL in the nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTP20 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UTP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus ISS 15590835
GO:0005737 cytoplasm ISS 17652137
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with UTP20: view

Pathways & Interactions for UTP20 Gene

genes like me logo Genes that share pathways with UTP20: view

Gene Ontology (GO) - Biological Process for UTP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS 15590835
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000472 endonucleolytic cleavage to generate mature 5-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS 17652137
GO:0000480 endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS 17652137
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with UTP20: view

No data available for SIGNOR curated interactions for UTP20 Gene

Drugs & Compounds for UTP20 Gene

No Compound Related Data Available

Transcripts for UTP20 Gene

Unigene Clusters for UTP20 Gene

UTP20, small subunit (SSU) processome component, homolog (yeast):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTP20 Gene

No ASD Table

Relevant External Links for UTP20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UTP20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UTP20 Gene

Protein differential expression in normal tissues from HIPED for UTP20 Gene

This gene is overexpressed in Stomach (16.9), Blymphocyte (10.9), and Adrenal (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UTP20 Gene

Protein tissue co-expression partners for UTP20 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UTP20 Gene:


SOURCE GeneReport for Unigene cluster for UTP20 Gene:


mRNA Expression by UniProt/SwissProt for UTP20 Gene:

Tissue specificity: Expressed in appendix, brain, colon, fetal liver, heart, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus.
genes like me logo Genes that share expression patterns with UTP20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UTP20 Gene

Orthologs for UTP20 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UTP20 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UTP20 33 34
  • 99.25 (n)
(Canis familiaris)
Mammalia UTP20 33 34
  • 89.61 (n)
(Bos Taurus)
Mammalia UTP20 33 34
  • 89.14 (n)
(Rattus norvegicus)
Mammalia Utp20 33
  • 84.29 (n)
(Mus musculus)
Mammalia Utp20 33 16 34
  • 84.25 (n)
(Monodelphis domestica)
Mammalia UTP20 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia UTP20 34
  • 73 (a)
(Gallus gallus)
Aves UTP20 33 34
  • 69.14 (n)
(Anolis carolinensis)
Reptilia UTP20 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia utp20 33
  • 65.96 (n)
(Danio rerio)
Actinopterygii im:7159098 33
  • 60.89 (n)
UTP20 34
  • 57 (a)
wufb83c08 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1547 33
fruit fly
(Drosophila melanogaster)
Insecta CG4554 33 34
  • 42.13 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005033 33
  • 40.84 (n)
(Caenorhabditis elegans)
Secernentea tag-184 33 34
  • 42.8 (n)
C56E6.9 34
  • 22 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17425g 33
  • 43.27 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL006W 33
  • 42.44 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP20 33 34 36
  • 42.3 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes utp20 33
  • 43.44 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02494 33
  • 41.19 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
Species where no ortholog for UTP20 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTP20 Gene

Gene Tree for UTP20 (if available)
Gene Tree for UTP20 (if available)

Paralogs for UTP20 Gene

No data available for Paralogs for UTP20 Gene

Variants for UTP20 Gene

Sequence variations from dbSNP and Humsavar for UTP20 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs140657361 A breast cancer sample 101,352,104(+) TTGCA(A/T)ACATC reference, missense
VAR_036275 A breast cancer sample
rs1000015666 -- 101,371,735(+) CACCA(A/C/T)GTTGG intron-variant
rs1000017917 -- 101,299,766(+) ATTAA(C/G)TTACC reference, missense
rs1000070312 -- 101,326,425(+) CCTTG(A/G)AAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UTP20 Gene

Variant ID Type Subtype PubMed ID
nsv53174 CNV deletion 16902084
nsv527505 CNV loss 19592680
nsv527122 CNV loss 19592680
nsv510315 OTHER sequence alteration 20534489
nsv470315 CNV gain 18288195
esv3630567 CNV loss 21293372
esv3549687 CNV deletion 23714750
esv2746279 CNV deletion 23290073
esv2746278 CNV deletion 23290073
esv2663815 CNV deletion 23128226
esv2497077 CNV deletion 19546169
esv2152079 CNV deletion 18987734

Variation tolerance for UTP20 Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.16; 80.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTP20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTP20 Gene

Disorders for UTP20 Gene

Relevant External Links for UTP20

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UTP20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTP20 Gene

Publications for UTP20 Gene

  1. Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing. (PMID: 17498821) Wang Y … Ke Y (Biochimica et biophysica acta 2007) 2 3 4 60
  2. Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis. (PMID: 9673349) Schwirzke M … Weidle UH (Anticancer research 1998) 2 3 4 60
  3. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PMID: 17903303) O'Donnell CJ … Demissie S (BMC medical genetics 2007) 3 45 60
  4. Mapping nucleolar localization sequences of 1A6/DRIM. (PMID: 16458307) Liu J … Ke Y (FEBS letters 2006) 3 4 60
  5. KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential. (PMID: 16053918) Yang L … Ke Y (Biochemical and biophysical research communications 2005) 3 4 60

Products for UTP20 Gene

Sources for UTP20 Gene

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