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Aliases for UTP20 Gene

Aliases for UTP20 Gene

  • UTP20, Small Subunit (SSU) Processome Component, Homolog (Yeast) 2 3
  • DRIM 3 4 6
  • Down-Regulated In Metastasis Protein 3 4
  • Down Regulated In Metastasis 2 3
  • Novel Nucleolar Protein 73 3 4
  • NNP73 3 4
  • Small Subunit Processome Component 20 Homolog 3
  • Protein Key-1A6 4

External Ids for UTP20 Gene

Previous GeneCards Identifiers for UTP20 Gene

  • GC12P100198
  • GC12P101673
  • GC12P098734

Summaries for UTP20 Gene

Entrez Gene Summary for UTP20 Gene

  • UTP20 is a component of the U3 small nucleolar RNA (snoRNA) (SNORD3A; MIM 180710) protein complex (U3 snoRNP) and is involved in 18S rRNA processing (Wang et al., 2007 [PubMed 17498821]).[supplied by OMIM, Jun 2009]

GeneCards Summary for UTP20 Gene

UTP20 (UTP20, Small Subunit (SSU) Processome Component, Homolog (Yeast)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for UTP20 Gene

  • Involved in 18S pre-rRNA processing. Associates with U3 snoRNA.

Gene Wiki entry for UTP20 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP20 Gene

Genomics for UTP20 Gene

Regulatory Elements for UTP20 Gene

Genomic Location for UTP20 Gene

101,280,109 bp from pter
101,386,619 bp from pter
106,511 bases
Plus strand

Genomic View for UTP20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UTP20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP20 Gene

Proteins for UTP20 Gene

  • Protein details for UTP20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small subunit processome component 20 homolog
    Protein Accession:
    Secondary Accessions:
    • Q9H3H4

    Protein attributes for UTP20 Gene

    2785 amino acids
    Molecular mass:
    318385 Da
    Quaternary structure:
    • Interacts with FBL and PPP1R26.
    • Sequence=AAG35208.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for UTP20 Gene

Proteomics data for UTP20 Gene at MOPED

Post-translational modifications for UTP20 Gene

  • Ubiquitination at Lys1149
  • Modification sites at PhosphoSitePlus

Other Protein References for UTP20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UTP20 Gene

Domains for UTP20 Gene

Protein Domains for UTP20 Gene


Suggested Antigen Peptide Sequences for UTP20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O75691
  • Belongs to the UTP20 family.
  • Contains 2 HEAT repeats.
genes like me logo Genes that share domains with UTP20: view

No data available for Gene Families for UTP20 Gene

Function for UTP20 Gene

Molecular function for UTP20 Gene

UniProtKB/Swiss-Prot Function: Involved in 18S pre-rRNA processing. Associates with U3 snoRNA.

Gene Ontology (GO) - Molecular Function for UTP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 16053918
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with UTP20: view

Phenotypes for UTP20 Gene

GenomeRNAi human phenotypes for UTP20:
genes like me logo Genes that share phenotypes with UTP20: view

miRNA for UTP20 Gene

miRTarBase miRNAs that target UTP20

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UTP20 Gene

Localization for UTP20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP20 Gene

Nucleus, nucleolus. Note=Colocalizes with NCL in the nucleolus.

Subcellular locations from

Jensen Localization Image for UTP20 Gene COMPARTMENTS Subcellular localization image for UTP20 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for UTP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm ISS 17652137
GO:0005730 nucleolus ISS 15590835
GO:0005737 cytoplasm ISS 17652137
GO:0030686 90S preribosome ISS 12150911
GO:0030688 preribosome, small subunit precursor ISS 17652137
genes like me logo Genes that share ontologies with UTP20: view

Pathways for UTP20 Gene

SuperPathways for UTP20 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UTP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS 15590835
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000472 endonucleolytic cleavage to generate mature 5-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS 17652137
GO:0000480 endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS 17652137
GO:0006364 rRNA processing IMP 17498821
genes like me logo Genes that share ontologies with UTP20: view

No data available for Pathways by source for UTP20 Gene

Transcripts for UTP20 Gene

Unigene Clusters for UTP20 Gene

UTP20, small subunit (SSU) processome component, homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UTP20 Gene

No ASD Table

Relevant External Links for UTP20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UTP20 Gene

mRNA expression in normal human tissues for UTP20 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UTP20 Gene

SOURCE GeneReport for Unigene cluster for UTP20 Gene Hs.295732

mRNA Expression by UniProt/SwissProt for UTP20 Gene

Tissue specificity: Expressed in appendix, brain, colon, fetal liver, heart, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus.
genes like me logo Genes that share expressions with UTP20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UTP20 Gene

Orthologs for UTP20 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UTP20 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UTP20 35
  • 99.25 (n)
  • 99.02 (a)
UTP20 36
  • 99 (a)
(Bos Taurus)
Mammalia UTP20 35
  • 89.14 (n)
  • 90.18 (a)
UTP20 36
  • 90 (a)
(Canis familiaris)
Mammalia UTP20 35
  • 89.61 (n)
  • 90.35 (a)
UTP20 36
  • 90 (a)
(Mus musculus)
Mammalia Utp20 35
  • 84.25 (n)
  • 86.09 (a)
Utp20 16
Utp20 36
  • 86 (a)
(Monodelphis domestica)
Mammalia UTP20 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia UTP20 36
  • 73 (a)
(Rattus norvegicus)
Mammalia Utp20 35
  • 84.29 (n)
  • 86.1 (a)
(Gallus gallus)
Aves UTP20 35
  • 69.14 (n)
  • 69.67 (a)
UTP20 36
  • 69 (a)
(Anolis carolinensis)
Reptilia UTP20 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia utp20 35
  • 65.96 (n)
  • 64.46 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1547 35
(Danio rerio)
Actinopterygii im:7159098 35
  • 60.89 (n)
  • 58.24 (a)
UTP20 36
  • 57 (a)
wufb83c08 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005033 35
  • 40.84 (n)
  • 26.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4554 35
  • 42.13 (n)
  • 29.11 (a)
CG4554 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea C56E6.9 36
  • 22 (a)
tag-184 35
  • 42.8 (n)
  • 27.1 (a)
tag-184 36
  • 24 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL006W 35
  • 42.44 (n)
  • 27.12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP20 35
  • 42.3 (n)
  • 26.98 (a)
UTP20 36
  • 23 (a)
UTP20 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17425g 35
  • 43.27 (n)
  • 28.44 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02494 35
  • 41.19 (n)
  • 26.88 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes utp20 35
  • 43.44 (n)
  • 29.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for UTP20:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTP20 Gene

Gene Tree for UTP20 (if available)
Gene Tree for UTP20 (if available)

Paralogs for UTP20 Gene

No data available for Paralogs for UTP20 Gene

Variants for UTP20 Gene

Sequence variations from dbSNP and Humsavar for UTP20 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs703711 -- 101,280,507(+) GAAGT(C/G)TGGAC intron-variant
rs703712 -- 101,287,295(-) GTAAA(A/G)GCTGG intron-variant
rs703713 -- 101,288,433(-) AATCC(C/T)CCCAT intron-variant
rs703714 -- 101,289,237(-) ACCAC(A/G)CCCAG intron-variant
rs703715 -- 101,290,151(-) AGTGC(A/G)TTTTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for UTP20 Gene

Variant ID Type Subtype PubMed ID
nsv470315 CNV Gain 18288195
esv2746278 CNV Deletion 23290073
nsv527122 CNV Loss 19592680
nsv510315 CNV Loss 20534489
esv2497077 CNV Deletion 19546169
esv2152079 CNV Deletion 18987734
esv2746279 CNV Deletion 23290073
esv2663815 CNV Deletion 23128226
nsv53174 CNV Loss 16902084
nsv527505 CNV Loss 19592680

Relevant External Links for UTP20 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTP20 Gene

Disorders for UTP20 Gene

Relevant External Links for UTP20

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with UTP20: view

No data available for UniProtKB/Swiss-Prot for UTP20 Gene

Publications for UTP20 Gene

  1. Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis. (PMID: 9673349) Schwirzke M. … Weidle U.H. (Anticancer Res. 1998) 2 3 4
  2. Directed proteomic analysis of the human nucleolus. (PMID: 11790298) Andersen J.S. … Lamond A.I. (Curr. Biol. 2002) 3 4
  3. The small-subunit processome is a ribosome assembly intermediate. (PMID: 15590835) Bernstein K.A. … Baserga S.J. (Eukaryotic Cell 2004) 2 3
  4. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  5. A panoramic view of yeast noncoding RNA processing. (PMID: 12837249) Peng W.T. … Hughes T.R. (Cell 2003) 2 3

Products for UTP20 Gene

Sources for UTP20 Gene

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