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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UTP20 Gene

protein-coding   GIFtS: 46
GCID: GC12P101673

UTP20, Small Subunit (SSU) Processome Component, Homolog...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UTP20, Small Subunit (SSU) Processome Component, Homolog (Yeast)1 2     Novel Nucleolar Protein 732 3
DRIM2 3 5     NNP732 3
Down Regulated In Metastasis1 2     Small Subunit Processome Component 20 Homolog2
Down-Regulated In Metastasis Protein2 3     Protein Key-1A63

External Ids:    HGNC: 178971   Entrez Gene: 273402   Ensembl: ENSG000001208007   OMIM: 6128225   UniProtKB: O756913   

Export aliases for UTP20 gene to outside databases

Previous GC identifers: GC12P100198 GC12P098734


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UTP20 Gene:
UTP20 is a component of the U3 small nucleolar RNA (snoRNA) (SNORD3A; MIM 180710) protein complex (U3 snoRNP) and
is involved in 18S rRNA processing (Wang et al., 2007 (PubMed 17498821)).(supplied by OMIM, Jun 2009)

GeneCards Summary for UTP20 Gene: 
UTP20 (UTP20, small subunit (SSU) processome component, homolog (yeast)) is a protein-coding gene. Diseases associated with UTP20 include atherosclerosis, and prostatitis. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: UTP20_HUMAN, O75691
Function: Involved in 18S pre-rRNA processing. Associates with U3 snoRNA

Gene Wiki entry for UTP20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UTP20 gene promoter:
         HFH-3   USF1   XBP-1   POU6F1 (c2)   Arnt   Evi-1   FOXI1   AREB6   USF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUTP20 promoter sequence
   Search SABiosciences Chromatin IP Primers for UTP20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UTP20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23   Ensembl cytogenetic band:  12q23.2   HGNC cytogenetic band: 12q23

UTP20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UTP20 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P101673:  view genomic region     (about GC identifiers)

Start:
101,673,887 bp from pter      End:
101,780,397 bp from pter
Size:
106,511 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UTP20_HUMAN, O75691 (See protein sequence)
Recommended Name: Small subunit processome component 20 homolog  
Size: 2785 amino acids; 318385 Da
Subunit: Interacts with FBL and PPP1R26
Subcellular location: Nucleus, nucleolus. Note=Colocalizes with NCL in the nucleolus
Sequence caution: Sequence=AAG35208.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q9H3H4

Explore the universe of human proteins at neXtProt for UTP20: NX_O75691

Explore proteomics data for UTP20 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75691

  • UTP20 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UTP20 Protein Expression
    REFSEQ proteins: NP_055318.2  
    ENSEMBL proteins: 
     ENSP00000261637  

    Human Recombinant Protein Products for UTP20: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm ISS17652137
    GO:0005730nucleolus ISS15590835
    GO:0005737cytoplasm ISS17652137
    GO:003068690S preribosome ISS12150911
    GO:0030688preribosome, small subunit precursor ISS17652137

    UTP20 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR011430 DRIM
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O75691

    ProtoNet protein and cluster: O75691

    UniProtKB/Swiss-Prot: UTP20_HUMAN, O75691
    Similarity: Belongs to the UTP20 family
    Similarity: Contains 2 HEAT repeats


    UTP20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UTP20_HUMAN, O75691
    Function: Involved in 18S pre-rRNA processing. Associates with U3 snoRNA

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI16053918
         
    UTP20 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UTP20:
     Increased cell death in HCT116 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UTP20

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/184 Interacting proteins for UTP20 (O756911, 2, 3 ENSP000002616374) via UniProtKB, MINT, STRING, and/or I2D (see all 184)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=5 
    HIST1H4BP628053I2D: score=5 
    HIST1H4CP628053I2D: score=5 
    HIST1H4DP628053I2D: score=5 
    HIST1H4EP628053I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS15590835
    GO:0000472endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS17652137
    GO:0000480endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS17652137
    GO:0006364rRNA processing IMP17498821
    GO:0008285negative regulation of cell proliferation TAS9673349

    UTP20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UTP20

    Search CenterWatch for drugs/clinical trials and news about UTP20

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UTP20 gene: 
    NM_014503.2  

    Unigene Cluster for UTP20:

    UTP20, small subunit (SSU) processome component, homolog (yeast)
    Hs.295732  [show with all ESTs]
    Unigene Representative Sequence: NM_014503
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261637(uc001tia.1) ENST00000551825(uc009ztz.1) ENST00000551998
    ENST00000551345
    miRNA
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    Additional mRNA sequence: 

    AF072718.1 AJ006778.1 AK000333.1 AK297739.1 AK307934.1 

    4 DOTS entries:

    DT.306882  DT.92427436  DT.408548  DT.75121208 

    24/83 AceView cDNA sequences (see all 83):

    AA085514 BM970338 CD251476 AW955305 BP346218 BX485493 AI251481 AL545314 
    AF072718 AA708041 CR616735 BM561731 CB163774 CB139198 BX957203 AK000333 
    BM793235 BQ068937 AA953098 BI964775 BX113621 AI564185 BE875691 AJ006778 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UTP20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UTP20 Expression
    About this image


    See UTP20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UTP20

    SOURCE GeneReport for Unigene cluster: Hs.295732

    UniProtKB/Swiss-Prot: UTP20_HUMAN, O75691
    Tissue specificity: Expressed in appendix, brain, colon, fetal liver, heart, ovary, pancreas, placenta, prostate,
    skeletal muscle, small intestine, spleen, testis and thymus

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTP20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UTP20 gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Utp201 , 5 UTP20, small subunit (SSU) processome component, homolog more1, 5 84.37(n)1
    86.31(a)1
      10 (44.21 cM)5
    706831  NM_175158.31  NP_780367.21 
     887466075 
    chicken
    (Gallus gallus)
    Aves UTP201 UTP20, small subunit (SSU) processome component, homolog more 69.14(n)
    69.78(a)
      417933  XM_416174.3  XP_416174.2 
    lizard
    (Anolis carolinensis)
    Reptilia UTP206
    Uncharacterized protein
    68(a)
    1 ↔ 1
    5(28223299-28302376)
    African clawed frog
    (Xenopus laevis)
    Amphibia BG413953.12   -- 72.3(n)    BG413953.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb83c082 Transcribed sequence with weak similarity to protein more 74.94(n)    BQ605496.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG45541 CG4554 42.02(n)
    28.73(a)
      37570  NM_137832.1  NP_611676.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1841 Protein TAG-184 42.82(n)
    27.23(a)
      174080  NM_062922.2  NP_495323.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UTP20(YBL004W)4
    UTP201
    Component of the small-subunit (SSU) processome, which more4
    Utp20p1
    41.59(n)1
    26.08(a)1
      2(227636-235117)4
    8522821, 4  NP_009551.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G309901 down-regulated in metastasis (DRIM) domain-containing more 41.51(n)
    25.99(a)
      829224  NM_119247.6  NP_194828.7 


    ENSEMBL Gene Tree for UTP20 (if available)
    TreeFam Gene Tree for UTP20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2422 SNPs in UTP20 are shown (see all 2422)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362754
    A breast cancer sample4--see VAR_0362752 I F mis40--------
    VAR_0362744
    A breast cancer sample4--see VAR_0362742 K I mis40--------
    rs1854315731,2
    --101671946(+) TGAAAC/TGTGCA 1 -- us2k10--------
    rs2002911111,2
    --101672036(+) AAGGC-/TTTTAA 1 -- us2k10--------
    rs8243141,2
    C,F,A,H--101672039(+) GCTTTA/TAAAAA 1 -- us2k1 tfbs39Minor allele frequency- T:0.22NA WA EA 370
    rs8507861,2
    C,F,A,H--101672093(+) GGCACG/ATCAAT 1 -- us2k111Minor allele frequency- A:0.29NS EA NA WA CSA 660
    rs1901947311,2
    --101672133(+) ATGGAA/GGCATT 1 -- us2k10--------
    rs1482288861,2
    --101672215(+) GTTATA/GTTCAC 1 -- us2k10--------
    rs1825617951,2
    --101672346(+) ATCCTC/TGAATT 1 -- us2k10--------
    rs1872441011,2
    --101672347(+) TCCTCA/GAATTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UTP20 (101673887 - 101780397 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for UTP20:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2152079CNV Deletion18987734
    esv2497077CNV Deletion19546169
    esv2746279CNV Deletion23290073
    esv2746278CNV Deletion23290073
    esv2663815CNV Deletion23128226
    nsv53174CNV Loss16902084
    nsv510315CNV Loss20534489
    nsv527505CNV Loss19592680
    nsv527122CNV Loss19592680
    nsv470315CNV Gain18288195

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612822    OMIM disorders: --

    2 diseases for UTP20:    About MalaCards
    atherosclerosis    prostatitis


    UTP20 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UTP20

    Export disorders for UTP20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UTP20 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with UTP20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis. (PubMed id 9673349)1, 2, 3 Schwirzke M.... Weidle U.H. (1998)
    2. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PubMed id 17903303)1, 4 O'Donnell C.J....Demissie S. (2007)
    3. Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing. (PubMed id 17498821)1, 2 Wang Y....Ke Y. (2007)
    4. Mapping nucleolar localization sequences of 1A6/DRIM. (PubMed id 16458307)1, 2 Liu J....Ke Y. (2006)
    5. KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential. (PubMed id 16053918)1, 2 Yang L.... Ke Y. (2005)
    6. The small-subunit processome is a ribosome assembly i ntermediate. (PubMed id 15590835)1, 3 Bernstein K.A....Baserga S.J. (2004)
    7. A panoramic view of yeast noncoding RNA processing. (PubMed id 12837249)1, 3 Peng W.T....Hughes T.R. (2003)
    8. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    9. Directed proteomic analysis of the human nucleolus. (PubMed id 11790298)1, 2 Andersen J.S.... Lamond A.I. (2002)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27340 HGNC: 17897 AceView: DRIM Ensembl:ENSG00000120800 euGenes: HUgn27340
    ECgene: UTP20 H-InvDB: UTP20

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UTP20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UTP20 gene:
    Search GeneIP for patents involving UTP20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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