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Aliases for UTP18 Gene

Aliases for UTP18 Gene

  • UTP18, Small Subunit Processome Component 2 3
  • UTP18 Small Subunit Processome Component 3 5
  • WD Repeat-Containing Protein 50 3 4
  • WD Repeat Domain 50 2 3
  • WDR50 3 4
  • UTP18 Small Subunit (SSU) Processome Component Homolog (Yeast) 2
  • UTP18, Small Subunit (SSU) Processome Component, Homolog 3
  • UTP18 Small Subunit (SSU) Processome Component Homolog 3
  • CGI-48 3

External Ids for UTP18 Gene

Previous HGNC Symbols for UTP18 Gene

  • WDR50

Previous GeneCards Identifiers for UTP18 Gene

  • GC17P046694
  • GC17P049337
  • GC17P044707

Summaries for UTP18 Gene

GeneCards Summary for UTP18 Gene

UTP18 (UTP18, Small Subunit Processome Component) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for UTP18 Gene

  • Involved in nucleolar processing of pre-18S ribosomal RNA.

Gene Wiki entry for UTP18 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP18 Gene

Genomics for UTP18 Gene

Regulatory Elements for UTP18 Gene

Enhancers for UTP18 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UTP18 on UCSC Golden Path with GeneCards custom track

Promoters for UTP18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UTP18 on UCSC Golden Path with GeneCards custom track

Genomic Location for UTP18 Gene

51,260,528 bp from pter
51,297,936 bp from pter
37,409 bases
Plus strand

Genomic View for UTP18 Gene

Genes around UTP18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTP18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTP18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP18 Gene

Proteins for UTP18 Gene

  • Protein details for UTP18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U3 small nucleolar RNA-associated protein 18 homolog
    Protein Accession:
    Secondary Accessions:
    • Q9H4N6

    Protein attributes for UTP18 Gene

    556 amino acids
    Molecular mass:
    62004 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD34043.1; Type=Frameshift; Positions=19; Evidence={ECO:0000305}; Sequence=AAG01999.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for UTP18 Gene

Proteomics data for UTP18 Gene at MOPED

Post-translational modifications for UTP18 Gene

  • Ubiquitination at Lys 287, Lys 329, and Lys 519
  • Modification sites at PhosphoSitePlus

Other Protein References for UTP18 Gene

No data available for DME Specific Peptides for UTP18 Gene

Domains & Families for UTP18 Gene

Gene Families for UTP18 Gene

Protein Domains for UTP18 Gene

Suggested Antigen Peptide Sequences for UTP18 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat UTP18 family.
  • Contains 6 WD repeats.
  • Belongs to the WD repeat UTP18 family.
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with UTP18: view

Function for UTP18 Gene

Molecular function for UTP18 Gene

UniProtKB/Swiss-Prot Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
genes like me logo Genes that share phenotypes with UTP18: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP18 Gene

Localization for UTP18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP18 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for UTP18 Gene COMPARTMENTS Subcellular localization image for UTP18 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for UTP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0032040 small-subunit processome IBA --
GO:0034388 Pwp2p-containing subcomplex of 90S preribosome IBA --
genes like me logo Genes that share ontologies with UTP18: view

Pathways & Interactions for UTP18 Gene

genes like me logo Genes that share pathways with UTP18: view

Pathways by source for UTP18 Gene

Gene Ontology (GO) - Biological Process for UTP18 Gene


No data available for SIGNOR curated interactions for UTP18 Gene

Drugs & Compounds for UTP18 Gene

No Compound Related Data Available

Transcripts for UTP18 Gene

Unigene Clusters for UTP18 Gene

UTP18 small subunit (SSU) processome component homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UTP18 Gene

No ASD Table

Relevant External Links for UTP18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UTP18 Gene

mRNA expression in normal human tissues for UTP18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UTP18 Gene

This gene is overexpressed in Lung (20.5), Peripheral blood mononuclear cells (7.5), and CD8 Tcells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UTP18 Gene

SOURCE GeneReport for Unigene cluster for UTP18 Gene Hs.709327

genes like me logo Genes that share expression patterns with UTP18: view

Protein tissue co-expression partners for UTP18 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UTP18 Gene

Orthologs for UTP18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UTP18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UTP18 35
  • 88.73 (n)
  • 87.2 (a)
UTP18 36
  • 89 (a)
(Canis familiaris)
Mammalia UTP18 35
  • 89.73 (n)
  • 88.29 (a)
UTP18 36
  • 89 (a)
(Mus musculus)
Mammalia Utp18 35
  • 85.1 (n)
  • 81.75 (a)
Utp18 16
Utp18 36
  • 81 (a)
(Pan troglodytes)
Mammalia UTP18 35
  • 99.76 (n)
  • 99.82 (a)
(Rattus norvegicus)
Mammalia Utp18 35
  • 85.5 (n)
  • 82.75 (a)
(Monodelphis domestica)
Mammalia UTP18 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia UTP18 36
  • 47 (a)
(Gallus gallus)
Aves UTP18 35
  • 68.5 (n)
  • 63.14 (a)
UTP18 36
  • 52 (a)
(Anolis carolinensis)
Reptilia UTP18 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia utp18 35
  • 63.04 (n)
  • 58.64 (a)
(Danio rerio)
Actinopterygii utp18 35
  • 56.22 (n)
  • 53.52 (a)
utp18 36
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009046 35
  • 45.7 (n)
  • 33.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta wcd 35
  • 43.93 (n)
  • 33.33 (a)
wcd 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea B0280.9 36
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP18 36
  • 23 (a)
UTP18 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G14050 35
  • 49.35 (n)
  • 40.22 (a)
(Oryza sativa)
Liliopsida Os07g0603200 35
  • 48.18 (n)
  • 37.91 (a)
Species with no ortholog for UTP18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTP18 Gene

Gene Tree for UTP18 (if available)
Gene Tree for UTP18 (if available)

Paralogs for UTP18 Gene Pseudogenes for UTP18 Gene

genes like me logo Genes that share paralogs with UTP18: view

No data available for Paralogs for UTP18 Gene

Variants for UTP18 Gene

Sequence variations from dbSNP and Humsavar for UTP18 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1015709 -- 51,279,084(+) CTTAG(C/T)AACTT intron-variant
rs1019195 -- 51,278,160(+) TTTCC(A/G)AGTAG intron-variant
rs917654 -- 51,294,144(+) AAATT(C/G)TAGTC intron-variant
rs2318787 -- 51,270,174(+) TCTTC(C/T)CTTTT intron-variant
rs2318788 -- 51,270,259(+) ACATA(C/T)AGATT intron-variant

Variation tolerance for UTP18 Gene

Residual Variation Intolerance Score: 19.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for UTP18 Gene

Disorders for UTP18 Gene

Relevant External Links for UTP18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UTP18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTP18 Gene

Publications for UTP18 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 67
  2. The small-subunit processome is a ribosome assembly intermediate. (PMID: 15590835) Bernstein K.A. … Baserga S.J. (Eukaryotic Cell 2004) 2 3
  3. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  4. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3
  5. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3

Products for UTP18 Gene

Sources for UTP18 Gene