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Aliases for UTP18 Gene

Aliases for UTP18 Gene

  • UTP18 Small Subunit (SSU) Processome Component Homolog (Yeast) 2 3
  • WD Repeat-Containing Protein 50 3 4
  • WD Repeat Domain 50 2 3
  • WDR50 3 4
  • UTP18, Small Subunit (SSU) Processome Component, Homolog 3
  • U3 Small Nucleolar RNA-Associated Protein 18 Homolog 3
  • CGI-48 3

External Ids for UTP18 Gene

Previous HGNC Symbols for UTP18 Gene

  • WDR50

Previous GeneCards Identifiers for UTP18 Gene

  • GC17P046694
  • GC17P049337
  • GC17P044707

Summaries for UTP18 Gene

GeneCards Summary for UTP18 Gene

UTP18 (UTP18 Small Subunit (SSU) Processome Component Homolog (Yeast)) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes.

UniProtKB/Swiss-Prot for UTP18 Gene

  • Involved in nucleolar processing of pre-18S ribosomal RNA.

Gene Wiki entry for UTP18 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP18 Gene

Genomics for UTP18 Gene

Regulatory Elements for UTP18 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UTP18 Gene

51,260,487 bp from pter
51,297,936 bp from pter
37,450 bases
Plus strand

Genomic View for UTP18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UTP18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP18 Gene

Proteins for UTP18 Gene

  • Protein details for UTP18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U3 small nucleolar RNA-associated protein 18 homolog
    Protein Accession:
    Secondary Accessions:
    • Q9H4N6

    Protein attributes for UTP18 Gene

    556 amino acids
    Molecular mass:
    62004 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD34043.1; Type=Frameshift; Positions=19; Evidence={ECO:0000305}; Sequence=AAG01999.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for UTP18 Gene

Proteomics data for UTP18 Gene at MOPED

Post-translational modifications for UTP18 Gene

  • Ubiquitination at Lys287, Lys329, and Lys519
  • Modification sites at PhosphoSitePlus

Other Protein References for UTP18 Gene

No data available for DME Specific Peptides for UTP18 Gene

Domains for UTP18 Gene

Gene Families for UTP18 Gene

  • WDR :WD repeat domain containing

Protein Domains for UTP18 Gene

Suggested Antigen Peptide Sequences for UTP18 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y5J1
  • Belongs to the WD repeat UTP18 family.
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with UTP18: view

Function for UTP18 Gene

Molecular function for UTP18 Gene

UniProtKB/Swiss-Prot Function: Involved in nucleolar processing of pre-18S ribosomal RNA.

Gene Ontology (GO) - Molecular Function for UTP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with UTP18: view
genes like me logo Genes that share phenotypes with UTP18: view

Animal Model Products

CRISPR Products

miRNA for UTP18 Gene

miRTarBase miRNAs that target UTP18

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UTP18 Gene

Localization for UTP18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP18 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for UTP18 Gene COMPARTMENTS Subcellular localization image for UTP18 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for UTP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0032040 small-subunit processome IBA --
GO:0034388 Pwp2p-containing subcomplex of 90S preribosome IBA --
genes like me logo Genes that share ontologies with UTP18: view

Pathways for UTP18 Gene

genes like me logo Genes that share pathways with UTP18: view

Pathways by source for UTP18 Gene

1 KEGG pathway for UTP18 Gene

Gene Ontology (GO) - Biological Process for UTP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing --
genes like me logo Genes that share ontologies with UTP18: view

Transcripts for UTP18 Gene

Unigene Clusters for UTP18 Gene

UTP18 small subunit (SSU) processome component homolog (yeast):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UTP18

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTP18 Gene

No ASD Table

Relevant External Links for UTP18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UTP18 Gene

mRNA expression in normal human tissues for UTP18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UTP18 Gene

SOURCE GeneReport for Unigene cluster for UTP18 Gene Hs.709327

genes like me logo Genes that share expressions with UTP18: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UTP18 Gene

Orthologs for UTP18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UTP18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UTP18 35
  • 99.76 (n)
  • 99.82 (a)
(Bos Taurus)
Mammalia UTP18 35
  • 88.73 (n)
  • 87.2 (a)
UTP18 36
  • 89 (a)
(Canis familiaris)
Mammalia UTP18 35
  • 89.73 (n)
  • 88.29 (a)
UTP18 36
  • 89 (a)
(Mus musculus)
Mammalia Utp18 35
  • 85.1 (n)
  • 81.75 (a)
Utp18 16
Utp18 36
  • 81 (a)
(Monodelphis domestica)
Mammalia UTP18 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia UTP18 36
  • 47 (a)
(Rattus norvegicus)
Mammalia Utp18 35
  • 85.5 (n)
  • 82.75 (a)
(Gallus gallus)
Aves UTP18 35
  • 68.5 (n)
  • 63.14 (a)
UTP18 36
  • 52 (a)
(Anolis carolinensis)
Reptilia UTP18 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia utp18 35
  • 63.04 (n)
  • 58.64 (a)
(Danio rerio)
Actinopterygii utp18 35
  • 56.22 (n)
  • 53.52 (a)
utp18 36
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009046 35
  • 45.7 (n)
  • 33.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta wcd 35
  • 43.93 (n)
  • 33.33 (a)
wcd 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea B0280.9 36
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP18 36
  • 23 (a)
UTP18 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G14050 35
  • 49.35 (n)
  • 40.22 (a)
(Oryza sativa)
Liliopsida Os07g0603200 35
  • 48.18 (n)
  • 37.91 (a)
Species with no ortholog for UTP18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTP18 Gene

Gene Tree for UTP18 (if available)
Gene Tree for UTP18 (if available)

Paralogs for UTP18 Gene Pseudogenes for UTP18 Gene

genes like me logo Genes that share paralogs with UTP18: view

No data available for Paralogs for UTP18 Gene

Variants for UTP18 Gene

Sequence variations from dbSNP and Humsavar for UTP18 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs917654 -- 51,294,144(+) AAATT(C/G)TAGTC intron-variant
rs1015709 -- 51,279,084(+) CTTAG(C/T)AACTT intron-variant
rs1019195 -- 51,278,160(+) TTTCC(A/G)AGTAG intron-variant
rs2318787 -- 51,270,174(+) TCTTC(C/T)CTTTT intron-variant
rs2318788 -- 51,270,259(+) ACATA(C/T)AGATT intron-variant

Relevant External Links for UTP18 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UTP18 Gene

Disorders for UTP18 Gene

No disorders were found for UTP18 Gene.

No data available for UniProtKB/Swiss-Prot for UTP18 Gene

Publications for UTP18 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  3. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The small-subunit processome is a ribosome assembly intermediate. (PMID: 15590835) Bernstein K.A. … Baserga S.J. (Eukaryotic Cell 2004) 2 3

Products for UTP18 Gene

Sources for UTP18 Gene

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