UTP18 Gene
protein-coding GIFtS: 49
GCID: GC17P049337
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UTP18 small subunit (SSU) processome component homolog (yeast)(Previous name: WD repeat domain 50 )
(Previous symbol: WDR50)
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Aliases
for UTP18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| UTP18 Small Subunit (SSU) Processome Component Homolog (Yeast)1 2 | | WD Repeat-Containing Protein 502 3 | | WDR501 2 3 | | U3 Small Nucleolar RNA-Associated Protein 18 Homolog2 | | CGI-481 2 | | UTP18, Small Subunit (SSU) Processome Component, Homolog2 | | WD Repeat Domain 501 2 | | |
Export aliases for UTP18 gene to outside databasesPrevious GC identifers: GC17P046694 GC17P044707 |
Summaries
for UTP18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UTP18_HUMAN, Q9Y5J1Function: Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity)
Gene Wiki entry for UTP18
|
Genomic Views
for UTP18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UTP18 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 POU2F2 RORalpha2 POU2F2C NRF-2 POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for UTP18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UTP18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.33 Ensembl cytogenetic band: 17q21.33 HGNC cytogenetic band: 17q21.33UTP18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P049337: view genomic region
(about GC identifiers)
Start:
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49,337,889 bp from pter |
End:
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49,375,297 bp from pter |
Size:
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37,409 bases |
Orientation:
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plus strand |
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Proteins
for UTP18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UTP18_HUMAN, Q9Y5J1 (See
protein sequence)Recommended Name: U3 small nucleolar RNA-associated protein 18 homolog Size: 556 amino acids; 62004 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=AAD34043.1; Type=Frameshift; Positions=19; Sequence=AAG01999.1; Type=Erroneous initiation;
Secondary accessions: Q9H4N6Explore the universe of human proteins at neXtProt for UTP18: NX_Q9Y5J1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y5J1
UTP18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057085.2
ENSEMBL proteins: ENSP00000225298 ENSP00000441335 ENSP00000462614 ENSP00000464095 ENSP00000464194 ENSP00000463499
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
UTP18 for ontologies About GeneDecksing
UTP18 Antibody Products:
Assay Products for UTP18: |
Protein
Domains /
Families
for UTP18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UTP18 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y5J1ProtoNet protein and cluster: Q9Y5J1 UniProtKB/Swiss-Prot: UTP18_HUMAN, Q9Y5J1Similarity: Belongs to the WD repeat UTP18 familySimilarity: Contains 6 WD repeats |
Function
for UTP18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UTP18_HUMAN, Q9Y5J1Function: Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UTP18 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UTP18 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UTP18 (NM_016001) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UTP18 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTP18 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTP18 |
6 GenomeRNAi human phenotypes for UTP18:
|
Pathways & Interactions
for UTP18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ribosome biogenesis in eukaryotes | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for UTP18):
UTP18 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UTP18
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/83 Interacting proteins for UTP18 (Q9Y5J13 ENSP000002252984) via UniProtKB, MINT, STRING, and/or I2D (see all 83)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006364 | rRNA processing |
IEA | -- |
UTP18 for ontologies About GeneDecksing
|
Drugs & Compounds
for UTP18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UTP18
Search CenterWatch for drugs/clinical trials and news about UTP18
|
Transcripts
for UTP18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UTP18 gene: NM_016001.2 Unigene Cluster for UTP18: UTP18 small subunit (SSU) processome component homolog (yeast) Hs.709327 [show with all ESTs]Unigene Representative Sequence: NM_0160017 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000225298(uc002its.3) ENST00000508506 ENST00000583725 ENST00000583205
ENST00000579261 ENST00000582832 ENST00000582150
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UTP18 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UTP18 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UTP18 (NM_016001) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UTP18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTP18 |
Additional cDNA sequence: AF151806.1 AK026355.1 AK314399.1 AY007138.1 BC001535.2 BC025276.1 14 DOTS entries: DT.99931457 DT.100700026 DT.100787220 DT.417840 DT.95185086 DT.417842 DT.95185054 DT.95336702 DT.91653673 DT.95185093 DT.120936976 DT.120937084 DT.92442034 DT.95185092 24/42 AceView cDNA sequences (see all 42): BM703231 AA286919 AI127256 AW059673 BF594314 CB215397 BC025276 AI761175 BM728330 BM994012 BM548967 BM464618 AI554162 BF437155 AI656528 BQ721576 AY007138 CB148440 BQ646118 BE348718 BP371469 AA576635 BF591164 BM989345
GeneLoc Exon Structure
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Expression
for UTP18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UTP18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGCAGCTTT
About this image
See UTP18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UTP18
SOURCE GeneReport for Unigene cluster: Hs.709327
SABiosciences Custom PCR Arrays for UTP18
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UTP18
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UTP18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UTP18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UTP18 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTP18 |
Orthologs
for UTP18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UTP18 gene from 10/31 species (see all 31) About this table
ENSEMBL Gene Tree for UTP18 (if available)
TreeFam Gene Tree for UTP18 (if available) |
Paralogs
for UTP18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UTP18 gene
UTP18 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for UTP18
PGOHUM00000235049
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Genomic Variants
for UTP18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UTP18 (49337889 - 49375297 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UTP18: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UTP18 |
|
Disorders
/ Diseases
for UTP18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UTP18 for disorders About GeneDecksing
OMIM gene information: 612816
OMIM disorders: --
1  disease for UTP18: About MalaCardsleukemia
Export disorders for UTP18 gene to outside databases
|
Publications
for UTP18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UTP18 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with UTP18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The small-subunit processome is a ribosome assembly i ntermediate. (PubMed id 15590835)1, 3 Bernstein K.A....Baserga S.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
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External Searches for UTP18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing UTP18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UTP18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UTP18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UTP18 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for UTP18 gene:
Search GeneIP for patents involving UTP18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UTP18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UTP18 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UTP18 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UTP18 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UTP18 | | OriGene 3'-UTR Clone for UTP18 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UTP18 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UTP18 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UTP18 | | OriGene Custom Protein Services for UTP18 | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UTP18 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UTP18 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UTP18 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UTP18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UTP18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UTP18 |
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| | | | Search Tocris compounds for UTP18 |
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 | | | UTP18 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTP18 |
|  |  |  | | | | ThermoFisher Antibody for UTP18 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTP18 |
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