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Aliases for UTP18 Gene

Aliases for UTP18 Gene

  • UTP18, Small Subunit Processome Component 2 3 5
  • WD Repeat-Containing Protein 50 3 4
  • WD Repeat Domain 50 2 3
  • WDR50 3 4
  • UTP18 Small Subunit (SSU) Processome Component Homolog (Yeast) 2
  • UTP18, Small Subunit (SSU) Processome Component, Homolog 3
  • U3 Small Nucleolar RNA-Associated Protein 18 Homolog 3
  • CGI-48 3

External Ids for UTP18 Gene

Previous HGNC Symbols for UTP18 Gene

  • WDR50

Previous GeneCards Identifiers for UTP18 Gene

  • GC17P046694
  • GC17P049337
  • GC17P044707

Summaries for UTP18 Gene

GeneCards Summary for UTP18 Gene

UTP18 (UTP18, Small Subunit Processome Component) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for UTP18 Gene

  • Involved in nucleolar processing of pre-18S ribosomal RNA.

Gene Wiki entry for UTP18 Gene

Additional gene information for UTP18 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP18 Gene

Genomics for UTP18 Gene

Regulatory Elements for UTP18 Gene

Enhancers for UTP18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H051257 1.1 ENCODE 49 -0.7 -680 5 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 UTP18 MBTD1 NME1 XYLT2 ENSG00000264895
GH17H051164 1.1 ENCODE 35.1 -93.8 -93847 3 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B NME2 UTP18 LUC7L3 MBTD1 COL1A1 ENSG00000279089
GH17H050395 1.2 ENCODE 29.3 -863.7 -863718 2 MLX DMAP1 SLC30A9 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1 RCOR2 ENSG00000262837 MBTD1 LOC105371824 LUC7L3 UTP18 CACNA1G-AS1 FLJ45513 FAM117A KAT7 XYLT2
GH17H051152 1.2 ENCODE 25.9 -106.9 -106850 2 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC MBTD1 LUC7L3 NME1 COL1A1 UTP18 NME2 LOC105371824 CACNA1G-AS1 SPAG9 SGCA
GH17H050718 1.4 ENCODE dbSUPER 20.8 -540.0 -539991 3 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 MBTD1 ENSG00000262837 UTP18 ANKRD40 LUC7L3 FAM117A FLJ45513 KAT7 TAC4 ABCC3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UTP18 on UCSC Golden Path with GeneCards custom track

Promoters for UTP18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095806 -128 3201 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9

Genomic Location for UTP18 Gene

Chromosome:
17
Start:
51,260,528 bp from pter
End:
51,297,936 bp from pter
Size:
37,409 bases
Orientation:
Plus strand

Genomic View for UTP18 Gene

Genes around UTP18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTP18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTP18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP18 Gene

Proteins for UTP18 Gene

  • Protein details for UTP18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5J1-UTP18_HUMAN
    Recommended name:
    U3 small nucleolar RNA-associated protein 18 homolog
    Protein Accession:
    Q9Y5J1
    Secondary Accessions:
    • Q9H4N6

    Protein attributes for UTP18 Gene

    Size:
    556 amino acids
    Molecular mass:
    62004 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34043.1; Type=Frameshift; Positions=19; Evidence={ECO:0000305}; Sequence=AAG01999.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for UTP18 Gene

Post-translational modifications for UTP18 Gene

  • Ubiquitination at Lys287, posLast=329329, and Lys519
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UTP18 Gene

Domains & Families for UTP18 Gene

Gene Families for UTP18 Gene

Protein Domains for UTP18 Gene

Suggested Antigen Peptide Sequences for UTP18 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5J1

UniProtKB/Swiss-Prot:

UTP18_HUMAN :
  • Belongs to the WD repeat UTP18 family.
Family:
  • Belongs to the WD repeat UTP18 family.
genes like me logo Genes that share domains with UTP18: view

Function for UTP18 Gene

Molecular function for UTP18 Gene

UniProtKB/Swiss-Prot Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.

Phenotypes From GWAS Catalog for UTP18 Gene

Gene Ontology (GO) - Molecular Function for UTP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with UTP18: view
genes like me logo Genes that share phenotypes with UTP18: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UTP18
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP18 Gene

Localization for UTP18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP18 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTP18 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nuclear membrane (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UTP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 15199122
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UTP18: view

Pathways & Interactions for UTP18 Gene

genes like me logo Genes that share pathways with UTP18: view

Gene Ontology (GO) - Biological Process for UTP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with UTP18: view

No data available for SIGNOR curated interactions for UTP18 Gene

Drugs & Compounds for UTP18 Gene

No Compound Related Data Available

Transcripts for UTP18 Gene

Unigene Clusters for UTP18 Gene

UTP18 small subunit (SSU) processome component homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UTP18
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for UTP18 Gene

No ASD Table

Relevant External Links for UTP18 Gene

GeneLoc Exon Structure for
UTP18
ECgene alternative splicing isoforms for
UTP18

Expression for UTP18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UTP18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UTP18 Gene

This gene is overexpressed in Lung (20.5), Peripheral blood mononuclear cells (7.5), and CD8 Tcells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UTP18 Gene



Protein tissue co-expression partners for UTP18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UTP18 Gene:

UTP18

SOURCE GeneReport for Unigene cluster for UTP18 Gene:

Hs.709327

Evidence on tissue expression from TISSUES for UTP18 Gene

  • Blood(4.2)
  • Liver(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with UTP18: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UTP18 Gene

Orthologs for UTP18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UTP18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTP18 33
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia UTP18 33 34
  • 89.73 (n)
cow
(Bos Taurus)
Mammalia UTP18 33 34
  • 88.73 (n)
rat
(Rattus norvegicus)
Mammalia Utp18 33
  • 85.5 (n)
mouse
(Mus musculus)
Mammalia Utp18 33 16 34
  • 85.1 (n)
oppossum
(Monodelphis domestica)
Mammalia UTP18 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UTP18 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves UTP18 33 34
  • 68.5 (n)
lizard
(Anolis carolinensis)
Reptilia UTP18 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia utp18 33
  • 63.04 (n)
zebrafish
(Danio rerio)
Actinopterygii utp18 33 34
  • 56.22 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009046 33
  • 45.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta wcd 33 34
  • 43.93 (n)
worm
(Caenorhabditis elegans)
Secernentea B0280.9 34
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP18 34 36
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G14050 33
  • 49.35 (n)
rice
(Oryza sativa)
Liliopsida Os07g0603200 33
  • 48.18 (n)
Species where no ortholog for UTP18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTP18 Gene

ENSEMBL:
Gene Tree for UTP18 (if available)
TreeFam:
Gene Tree for UTP18 (if available)

Paralogs for UTP18 Gene

Pseudogenes.org Pseudogenes for UTP18 Gene

genes like me logo Genes that share paralogs with UTP18: view

No data available for Paralogs for UTP18 Gene

Variants for UTP18 Gene

Sequence variations from dbSNP and Humsavar for UTP18 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000022706 -- 51,279,601(+) TTTAT(A/C/G)TTTTT intron-variant
rs1000075663 -- 51,274,385(+) CAGTA(C/G)TTTAG intron-variant
rs1000152256 -- 51,291,013(+) ACGTC(A/G)TGGAA intron-variant
rs1000240467 -- 51,259,316(+) ACACC(A/G)CTCCC intron-variant, upstream-variant-2KB
rs1000375758 -- 51,297,414(+) GAGCT(A/G)GATAA intron-variant

Variation tolerance for UTP18 Gene

Residual Variation Intolerance Score: 19.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTP18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTP18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UTP18 Gene

Disorders for UTP18 Gene

Relevant External Links for UTP18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTP18

No disorders were found for UTP18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTP18 Gene

Publications for UTP18 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 60
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The small-subunit processome is a ribosome assembly intermediate. (PMID: 15590835) Bernstein KA … Baserga SJ (Eukaryotic cell 2004) 2 3 60
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 60

Products for UTP18 Gene

Sources for UTP18 Gene

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