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Aliases for UTP15 Gene

Aliases for UTP15 Gene

  • UTP15, Small Subunit Processome Component 2 3
  • UTP15, U3 Small Nucleolar Ribonucleoprotein, Homolog (S. Cerevisiae) 2 5
  • UTP15 SSU Processome Component 2 3
  • UTP15, U3 Small Nucleolar Ribonucleoprotein, Homolog (Yeast) 2
  • UTP15, U3 Small Nucleolar Ribonucleoprotein, Homolog 3
  • Src-Associated Protein SAW 3
  • NET21 3

External Ids for UTP15 Gene

Previous GeneCards Identifiers for UTP15 Gene

  • GC05P072898
  • GC05P068067
  • GC05P072861

Summaries for UTP15 Gene

GeneCards Summary for UTP15 Gene

UTP15 (UTP15, Small Subunit Processome Component) is a Protein Coding gene. Among its related pathways are Gene Expression and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include poly(A) RNA binding and snoRNA binding.

UniProtKB/Swiss-Prot for UTP15 Gene

  • Involved in nucleolar processing of pre-18S ribosomal RNA.

Gene Wiki entry for UTP15 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP15 Gene

Genomics for UTP15 Gene

Regulatory Elements for UTP15 Gene

Promoters for UTP15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UTP15 on UCSC Golden Path with GeneCards custom track

Genomic Location for UTP15 Gene

Chromosome:
5
Start:
73,565,443 bp from pter
End:
73,583,377 bp from pter
Size:
17,935 bases
Orientation:
Plus strand

Genomic View for UTP15 Gene

Genes around UTP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP15 Gene

Proteins for UTP15 Gene

  • Protein details for UTP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TED0-UTP15_HUMAN
    Recommended name:
    U3 small nucleolar RNA-associated protein 15 homolog
    Protein Accession:
    Q8TED0
    Secondary Accessions:
    • B4DU75
    • B4DXK8
    • Q6IA60
    • Q96E08
    • Q9H9F8

    Protein attributes for UTP15 Gene

    Size:
    518 amino acids
    Molecular mass:
    58415 Da
    Quaternary structure:
    • Forms a complex with UTP4, NOL11, WDR43 and WDR75.
    SequenceCaution:
    • Sequence=BAB14271.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85020.1; Type=Frameshift; Positions=489; Evidence={ECO:0000305};

    Alternative splice isoforms for UTP15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UTP15 Gene

Proteomics data for UTP15 Gene at MOPED

Post-translational modifications for UTP15 Gene

  • Ubiquitination at Lys 36, Lys 80, Lys 155, and Lys 398
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UTP15 Gene

Domains & Families for UTP15 Gene

Gene Families for UTP15 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TED0

UniProtKB/Swiss-Prot:

UTP15_HUMAN :
  • Contains 7 WD repeats.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with UTP15: view

Function for UTP15 Gene

Molecular function for UTP15 Gene

UniProtKB/Swiss-Prot Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.
genes like me logo Genes that share phenotypes with UTP15: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP15 Gene

Localization for UTP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP15 Gene

Nucleus, nucleolus. Note=Found predominantly at the fibrillar center. {ECO:0000269 PubMed:24219289}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UTP15 Gene COMPARTMENTS Subcellular localization image for UTP15 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for UTP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA,IDA 24219289
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with UTP15: view

Pathways & Interactions for UTP15 Gene

genes like me logo Genes that share pathways with UTP15: view

Pathways by source for UTP15 Gene

Gene Ontology (GO) - Biological Process for UTP15 Gene

None

No data available for SIGNOR curated interactions for UTP15 Gene

Drugs & Compounds for UTP15 Gene

No Compound Related Data Available

Transcripts for UTP15 Gene

Unigene Clusters for UTP15 Gene

UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UTP15 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: -
SP6:

Relevant External Links for UTP15 Gene

GeneLoc Exon Structure for
UTP15
ECgene alternative splicing isoforms for
UTP15

Expression for UTP15 Gene

mRNA expression in normal human tissues for UTP15 Gene

Protein differential expression in normal tissues from HIPED for UTP15 Gene

This gene is overexpressed in Lung (15.8), Tlymphocyte (9.0), Spinal cord (6.8), and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UTP15 Gene



SOURCE GeneReport for Unigene cluster for UTP15 Gene Hs.406703

genes like me logo Genes that share expression patterns with UTP15: view

Protein tissue co-expression partners for UTP15 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UTP15 Gene

Orthologs for UTP15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UTP15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UTP15 35
  • 92.6 (n)
  • 95.56 (a)
UTP15 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UTP15 35
  • 89.95 (n)
  • 92.22 (a)
UTP15 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Utp15 35
  • 86.06 (n)
  • 90.08 (a)
Utp15 16
Utp15 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UTP15 35
  • 99.68 (n)
  • 99.61 (a)
UTP15 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Utp15 35
  • 87.29 (n)
  • 91.63 (a)
oppossum
(Monodelphis domestica)
Mammalia UTP15 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UTP15 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves UTP15 35
  • 69.54 (n)
  • 70.59 (a)
UTP15 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UTP15 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15637 35
utp15 35
  • 67.4 (n)
  • 69.48 (a)
zebrafish
(Danio rerio)
Actinopterygii utp15 35
  • 61.59 (n)
  • 59.52 (a)
utp15 36
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.428 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002088 35
  • 46.42 (n)
  • 41.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3071 35
  • 46.44 (n)
  • 39.75 (a)
CG3071 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y23H5B.5 36
  • 27 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL044C 35
  • 45.17 (n)
  • 34.46 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F13772g 35
  • 45.69 (n)
  • 34.75 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP15 35
  • 45.29 (n)
  • 32.99 (a)
UTP15 36
  • 30 (a)
OneToOne
UTP15 38
thale cress
(Arabidopsis thaliana)
eudicotyledons SWA1 35
  • 43.57 (n)
  • 36.23 (a)
rice
(Oryza sativa)
Liliopsida Os07g0224900 35
  • 43.06 (n)
  • 35.69 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09843 35
  • 41.34 (n)
  • 35.32 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes utp15 35
  • 46.61 (n)
  • 37.53 (a)
Species with no ortholog for UTP15:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTP15 Gene

ENSEMBL:
Gene Tree for UTP15 (if available)
TreeFam:
Gene Tree for UTP15 (if available)

Paralogs for UTP15 Gene

(1) SIMAP similar genes for UTP15 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with UTP15: view

No data available for Paralogs for UTP15 Gene

Variants for UTP15 Gene

Sequence variations from dbSNP and Humsavar for UTP15 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs16870608 - 73,572,497(+) GTCGT(C/T)ATGTT reference, missense
rs35313343 - 73,577,957(+) AGAAG(C/G)CCTGC reference, missense
rs35898225 - 73,579,984(+) TAGAA(A/C)CCTTG reference, missense
rs168223 -- 73,568,069(+) AGTCT(A/G)GGTGA intron-variant
rs343113 -- 73,583,708(-) tccat(C/G)tcatt downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for UTP15 Gene

Variant ID Type Subtype PubMed ID
nsv830346 CNV Loss 17160897
nsv830347 CNV Gain 17160897

Variation tolerance for UTP15 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTP15 Gene

HapMap Linkage Disequilibrium report
UTP15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTP15 Gene

Disorders for UTP15 Gene

Relevant External Links for UTP15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTP15

No disorders were found for UTP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTP15 Gene

Publications for UTP15 Gene

  1. Dynamics of WD-repeat containing proteins in SSU processome components. (PMID: 24754225) Wada K. … Horigome T. (Biochem. Cell Biol. 2014) 2 3
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3

Products for UTP15 Gene

Sources for UTP15 Gene

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