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Aliases for UTP15 Gene

Aliases for UTP15 Gene

  • UTP15, Small Subunit Processome Component 2 3 5
  • UTP15 SSU Processome Component 2 3
  • UTP15, U3 Small Nucleolar Ribonucleoprotein, Homolog (S. Cerevisiae) 2
  • UTP15, U3 Small Nucleolar Ribonucleoprotein, Homolog (Yeast) 2
  • U3 Small Nucleolar RNA-Associated Protein 15 Homolog 3
  • UTP15, U3 Small Nucleolar Ribonucleoprotein, Homolog 3
  • Src-Associated Protein SAW 3
  • NET21 3

External Ids for UTP15 Gene

Previous GeneCards Identifiers for UTP15 Gene

  • GC05P072898
  • GC05P068067
  • GC05P072861

Summaries for UTP15 Gene

GeneCards Summary for UTP15 Gene

UTP15 (UTP15, Small Subunit Processome Component) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include poly(A) RNA binding and snoRNA binding.

UniProtKB/Swiss-Prot for UTP15 Gene

  • Involved in nucleolar processing of pre-18S ribosomal RNA.

Gene Wiki entry for UTP15 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP15 Gene

Genomics for UTP15 Gene

Regulatory Elements for UTP15 Gene

Enhancers for UTP15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F073541 1 Ensembl ENCODE 25.9 -23.5 -23494 2.7 ELF3 SOX13 SAP130 ZIC2 ZNF48 RARA TEAD3 ZNF664 CTBP1 ZNF366 UTP15 ANKRA2 LINC01386 ENSG00000272525 ARHGEF28 FUNDC2P1
GH05F073544 0.2 ENCODE 23.7 -20.6 -20590 1.7 ATF1 MLX ARID4B DMAP1 ZNF48 ZNF207 SP5 NFYC MIER2 PPARG UTP15 ANKRA2 LINC01386 FUNDC2P1
GH05F074016 0.7 ENCODE 23.7 +452.1 452132 2.0 INSM2 ZNF76 KLF17 FEZF1 NFXL1 RAD21 ZNF2 ZEB1 ZNF155 GLIS2 ANKRA2 UTP15 NSA2 LOC105379035 LOC105379034
GH05F073563 0.7 ENCODE 23.5 +0.1 131 3.2 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 KLF13 SP3 SP5 UTP15 ANKRA2 RPL7P22 ARHGEF28
GH05F073495 1.1 ENCODE 22.6 -67.3 -67320 5.1 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 ZNF207 UTP15 ANKRA2 FCHO2 ENSG00000272525 RPL7P22 BTF3 GC05M073449
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UTP15 on UCSC Golden Path with GeneCards custom track

Promoters for UTP15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001410588 -242 3200 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 KLF13 SP3 SP5

Genomic Location for UTP15 Gene

Chromosome:
5
Start:
73,565,443 bp from pter
End:
73,583,377 bp from pter
Size:
17,935 bases
Orientation:
Plus strand

Genomic View for UTP15 Gene

Genes around UTP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP15 Gene

Proteins for UTP15 Gene

  • Protein details for UTP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TED0-UTP15_HUMAN
    Recommended name:
    U3 small nucleolar RNA-associated protein 15 homolog
    Protein Accession:
    Q8TED0
    Secondary Accessions:
    • B4DU75
    • B4DXK8
    • Q6IA60
    • Q96E08
    • Q9H9F8

    Protein attributes for UTP15 Gene

    Size:
    518 amino acids
    Molecular mass:
    58415 Da
    Quaternary structure:
    • Forms a complex with UTP4, NOL11, WDR43 and WDR75.
    SequenceCaution:
    • Sequence=BAB14271.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85020.1; Type=Frameshift; Positions=489; Evidence={ECO:0000305};

    Alternative splice isoforms for UTP15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UTP15 Gene

Post-translational modifications for UTP15 Gene

  • Ubiquitination at Lys 36, Lys 80, Lys 155, and Lys 398
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UTP15 Gene

Domains & Families for UTP15 Gene

Gene Families for UTP15 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TED0

UniProtKB/Swiss-Prot:

UTP15_HUMAN :
  • Contains 7 WD repeats.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with UTP15: view

Function for UTP15 Gene

Molecular function for UTP15 Gene

UniProtKB/Swiss-Prot Function:
Involved in nucleolar processing of pre-18S ribosomal RNA.

Gene Ontology (GO) - Molecular Function for UTP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24219289
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with UTP15: view
genes like me logo Genes that share phenotypes with UTP15: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP15 Gene

Localization for UTP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP15 Gene

Nucleus, nucleolus. Note=Found predominantly at the fibrillar center. {ECO:0000269 PubMed:24219289}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UTP15 Gene COMPARTMENTS Subcellular localization image for UTP15 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for UTP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA 24219289
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 24219289
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with UTP15: view

Pathways & Interactions for UTP15 Gene

genes like me logo Genes that share pathways with UTP15: view

Gene Ontology (GO) - Biological Process for UTP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with UTP15: view

No data available for SIGNOR curated interactions for UTP15 Gene

Transcripts for UTP15 Gene

Unigene Clusters for UTP15 Gene

UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTP15 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: -
SP6:

Relevant External Links for UTP15 Gene

GeneLoc Exon Structure for
UTP15
ECgene alternative splicing isoforms for
UTP15

Expression for UTP15 Gene

mRNA expression in normal human tissues for UTP15 Gene

Protein differential expression in normal tissues from HIPED for UTP15 Gene

This gene is overexpressed in Lung (15.8), Tlymphocyte (9.0), Spinal cord (6.8), and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UTP15 Gene



Protein tissue co-expression partners for UTP15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UTP15 Gene:

UTP15

SOURCE GeneReport for Unigene cluster for UTP15 Gene:

Hs.406703
genes like me logo Genes that share expression patterns with UTP15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UTP15 Gene

Orthologs for UTP15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UTP15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTP15 34 35
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia UTP15 34 35
  • 92.6 (n)
dog
(Canis familiaris)
Mammalia UTP15 34 35
  • 89.95 (n)
rat
(Rattus norvegicus)
Mammalia Utp15 34
  • 87.29 (n)
mouse
(Mus musculus)
Mammalia Utp15 34 16 35
  • 86.06 (n)
oppossum
(Monodelphis domestica)
Mammalia UTP15 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UTP15 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves UTP15 34 35
  • 69.54 (n)
lizard
(Anolis carolinensis)
Reptilia UTP15 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia utp15 34
  • 67.4 (n)
Str.15637 34
zebrafish
(Danio rerio)
Actinopterygii utp15 34 35
  • 61.59 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.428 34
fruit fly
(Drosophila melanogaster)
Insecta CG3071 34 35
  • 46.44 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002088 34
  • 46.42 (n)
worm
(Caenorhabditis elegans)
Secernentea Y23H5B.5 35
  • 27 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F13772g 34
  • 45.69 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP15 34 35 37
  • 45.29 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL044C 34
  • 45.17 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SWA1 34
  • 43.57 (n)
rice
(Oryza sativa)
Liliopsida Os07g0224900 34
  • 43.06 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes utp15 34
  • 46.61 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09843 34
  • 41.34 (n)
Species where no ortholog for UTP15 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTP15 Gene

ENSEMBL:
Gene Tree for UTP15 (if available)
TreeFam:
Gene Tree for UTP15 (if available)

Paralogs for UTP15 Gene

(1) SIMAP similar genes for UTP15 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with UTP15: view

No data available for Paralogs for UTP15 Gene

Variants for UTP15 Gene

Sequence variations from dbSNP and Humsavar for UTP15 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10515158 -- 73,566,724(+) CAGGA(C/T)TGCTT intron-variant, upstream-variant-2KB
rs10942676 -- 73,579,810(+) AAAAA(C/T)TTTTG intron-variant
rs111313040 -- 73,578,123(+) CTCTA(C/T)ATCAG intron-variant
rs111354892 -- 73,573,222(+) AAATC(A/G)TTATT intron-variant
rs111366538 -- 73,569,901(+) GACCA(C/T)AGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UTP15 Gene

Variant ID Type Subtype PubMed ID
esv3605417 CNV loss 21293372
nsv830346 CNV loss 17160897
nsv830347 CNV gain 17160897

Variation tolerance for UTP15 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTP15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTP15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTP15 Gene

Disorders for UTP15 Gene

Relevant External Links for UTP15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTP15

No disorders were found for UTP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTP15 Gene

Publications for UTP15 Gene

  1. Interaction, mobility, and phosphorylation of human orthologues of WD repeat-containing components of the yeast SSU processome t-UTP sub- complex. (PMID: 24219289) Sato M. … Horigome T. (Biochem. Cell Biol. 2013) 2 3 4 64
  2. Dynamics of WD-repeat containing proteins in SSU processome components. (PMID: 24754225) Wada K. … Horigome T. (Biochem. Cell Biol. 2014) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4 64

Products for UTP15 Gene

Sources for UTP15 Gene

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