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UTP15 Gene

protein-coding   GIFtS: 54
GCID: GC05P072861

UTP15, U3 Small Nucleolar Ribonucleoprotein, Homolog (S....

(Previous names: UTP15, U3 small nucleolar ribonucleoprotein, homolog (yeast))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UTP15, U3 Small Nucleolar Ribonucleoprotein, Homolog (S.
Cerevisiae)1 2
UTP15, U3 Small Nucleolar Ribonucleoprotein, Homolog (Yeast)1
NET212
Src-Associated Protein SAW2
U3 Small Nucleolar RNA-Associated Protein 15 Homolog2

External Ids:    HGNC: 257581   Entrez Gene: 841352   Ensembl: ENSG000001643387   UniProtKB: Q8TED03   

Export aliases for UTP15 gene to outside databases

Previous GC identifers: GC05P072898 GC05P068067


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UTP15 Gene:
UTP15 (UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with UTP15 include exostosis, and malaria.

UniProtKB/Swiss-Prot: UTP15_HUMAN, Q8TED0
Function: Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity)

Gene Wiki entry for UTP15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the UTP15 gene promoter:
         AML1a   ATF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   POU2F1   POU2F1a   POU2F1b   POU2F1c   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUTP15 promoter sequence
   Search Chromatin IP Primers for UTP15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UTP15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.2   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13.2

UTP15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UTP15 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P072861:  view genomic region     (about GC identifiers)

Start:
72,861,268 bp from pter      End:
72,877,794 bp from pter
Size:
16,527 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UTP15_HUMAN, Q8TED0 (See protein sequence)
Recommended Name: U3 small nucleolar RNA-associated protein 15 homolog  
Size: 518 amino acids; 58415 Da
Subunit: Forms a complex with CIRH1A, NOL11, WDR43 and WDR75
Sequence caution: Sequence=BAB14271.1; Type=Erroneous initiation; Sequence=BAB85020.1; Type=Frameshift;
Positions=489;
Secondary accessions: Q6IA60 Q96E08 Q9H9F8

Explore the universe of human proteins at neXtProt for UTP15: NX_Q8TED0

Explore proteomics data for UTP15 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys36, Lys80, Lys155, Lys398
  • Modification sites at PhosphoSitePlus

  • See UTP15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001271359.1  NP_001271360.1  NP_115551.2  

    ENSEMBL proteins: 
     ENSP00000424902   ENSP00000296792   ENSP00000421669   ENSP00000424334   ENSP00000424609  
     ENSP00000440796  

    UTP15 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for UTP15
    GenScript Custom Purified and Recombinant Proteins Services for UTP15
    Novus Biologicals UTP15 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UTP15

    UTP15 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for UTP15
    Cloud-Clone Corp. Antibodies for UTP15
    ThermoFisher Antibodies for UTP15
    Search LSBio for Antibodies for UTP15

    UTP15 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for UTP15
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UTP15
    Cloud-Clone Corp. CLIAs for UTP15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR018983 U3_snoRNA-assocProt_15_C
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8TED0

    ProtoNet protein and cluster: Q8TED0

    UniProtKB/Swiss-Prot: UTP15_HUMAN, Q8TED0
    Similarity: Contains 7 WD repeats


    UTP15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UTP15_HUMAN, Q8TED0
    Function: Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    UTP15 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for UTP15:
     Decreased TP53 protein express  Decreased viability of wild-ty  Nuclear 60S biogenesis defects  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UTP15
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UTP15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UTP15
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UTP15

    miRNA
    Products:
        
    miRTarBase miRNAs that target UTP15:
    hsa-mir-30c-5p (MIRT047963), hsa-let-7e-5p (MIRT051670), hsa-let-7b-5p (MIRT032450), hsa-mir-30a-5p (MIRT028625), hsa-mir-16-5p (MIRT001398)

    Block miRNA regulation of human, mouse, rat UTP15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UTP15 (see all 23):
    hsa-let-7d hsa-miR-605 hsa-let-7c hsa-miR-488 hsa-miR-606 hsa-miR-766 hsa-miR-520a-5p hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidUTP15 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UTP15
    Predesigned siRNA for gene silencing in human, mouse, rat UTP15

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UTP15

    Clone
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    OriGene clones in human, mouse for UTP15 (see all 7)
    OriGene ORF clones in mouse, rat for UTP15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UTP15 (NM_032175)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UTP15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTP15

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UTP15
    Browse ESI BIO Cell Lines and PureStem Progenitors for UTP15 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTP15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UTP15_HUMAN, Q8TED0: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion2
    peroxisome2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA--

    UTP15 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UTP15 About    
    See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for UTP15):
        Ribosome biogenesis in eukaryotes


    UTP15 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UTP15
    Interactions:

        Search GeneGlobe Interaction Network for UTP15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UTP15 (Q8TED02, 3 ENSP000002967924) via UniProtKB, MINT, STRING, and/or I2D (see all 167)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--

    UTP15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UTP15



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UTP15 gene (3 alternative transcripts): 
    NM_001284430.1  NM_001284431.1  NM_032175.3  

    Unigene Cluster for UTP15:

    UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)
    Hs.406703  [show with all ESTs]
    Unigene Representative Sequence: AL831972
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513824 ENST00000296792(uc003kcw.1 uc011cso.1 uc011csp.1 uc010ize.1)
    ENST00000510478 ENST00000509005 ENST00000508686 ENST00000508491 ENST00000512550
    ENST00000543251
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UTP15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UTP15 (see all 23):
    hsa-let-7d hsa-miR-605 hsa-let-7c hsa-miR-488 hsa-miR-606 hsa-miR-766 hsa-miR-520a-5p hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidUTP15 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UTP15
    Predesigned siRNA for gene silencing in human, mouse, rat UTP15
    Clone
    Products:
         
    OriGene clones in human, mouse for UTP15 (see all 7)
    OriGene ORF clones in mouse, rat for UTP15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UTP15 (NM_032175)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UTP15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTP15
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UTP15
    OriGene qSTAR qPCR primer pairs in human, mouse for UTP15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UTP15
      QuantiTect SYBR Green Assays in human, mouse, rat UTP15
      QuantiFast Probe-based Assays in human, mouse, rat UTP15

    Additional mRNA sequence: 

    AK022849.1 AK074217.1 AK300525.1 AK302021.1 AL831972.1 BC013064.1 CR457295.1 

    4 DOTS entries:

    DT.109162  DT.120872063  DT.70100961  DT.443440 

    Selected AceView cDNA sequences (see all 79):

    BM479492 AI759976 AA056166 BX279709 BC013064 AA046406 CR597969 BE018304 
    BQ434466 NM_032175 BX645006 AW241797 BF196563 AK074217 AL831972 AI423762 
    BX113170 CR457295 BU169606 BG110084 AI133338 BU844561 AW450077 BQ446992 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UTP15 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                          -                 -                                                           -                           
    SP2:                          -     -     -     -                                                                                       
    SP3:                    -     -                 -                                                                                       
    SP4:                                                                                                                                    
    SP5:                          -                                                                                                         


    ECgene alternative splicing isoforms for UTP15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UTP15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAGGAAGG
    UTP15 Expression
    About this image

    UTP15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UTP15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406703
        Custom PCR Arrays for UTP15
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UTP15
    OriGene qSTAR qPCR primer pairs in human, mouse for UTP15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UTP15
    QuantiTect SYBR Green Assays in human, mouse, rat UTP15
    QuantiFast Probe-based Assays in human, mouse, rat UTP15
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTP15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UTP15 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Utp151 , 5 UTP15, U3 small nucleolar ribonucleoprotein, homolog more1, 5 86.06(n)1
    90.08(a)1
      13 (51.87 cM)5
    1053721  NM_178918.31  NP_849249.11 
     982468455 
    chicken
    (Gallus gallus)
    Aves UTP151 UTP15, U3 small nucleolar ribonucleoprotein, homolog more 69.54(n)
    70.59(a)
      426152  NM_001012606.1  NP_001012624.1 
    lizard
    (Anolis carolinensis)
    Reptilia UTP156
    UTP15, U3 small nucleolar ribonucleoprotein, homol...
    71(a)
    1 ↔ 1
    2(15860296-15877523)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044048.12   -- 77.7(n)    BC044048.1 
    zebrafish
    (Danio rerio)
    Actinopterygii utp151 utp15, U3 small nucleolar ribonucleoprotein, homolog 61.59(n)
    59.52(a)
      325106  NM_199704.1  NP_955998.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG30711 CG3071 46.44(n)
    39.75(a)
      31213  NM_130637.3  NP_569993.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y23H5B.56
    Protein Y23H5B.5 (Y23H5B.5) mRNA, complete cds
    27(a)
    1 ↔ 1
    I(2498134-2506233) WBGene00021276
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UTP15(YMR093W)4
    UTP151
    Nucleolar protein, component of the small subunit (SSU) more4
    UTP151
    45.29(n)1
    32.99(a)1
      13(454015-455556)4
    8551181, 4  NP_013811.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SWA11 SWA1 43.57(n)
    36.23(a)
      819411  NM_130366.3  NP_182320.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g02249001 Os07g0224900 43.06(n)
    35.69(a)
      4342750  NM_001065746.2  NP_001059211.2 


    ENSEMBL Gene Tree for UTP15 (if available)
    TreeFam Gene Tree for UTP15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UTP15 gene
    1 SIMAP similar gene for UTP15 using alignment to 5 protein entries:     UTP15_HUMAN (see all proteins):
    GNB5

    UTP15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UTP15 (see all 363)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1512500831,2
    C--72863537(+) TGTGTA/GAAGAT 1 -- int10--------
    rs168705981,2
    C,F,H--72863652(+) AGTCTA/GTTGCT 1 -- int18Minor allele frequency- G:0.04NA NS CSA WA 474
    rs1830548041,2
    --72863702(+) AAGATA/GTGGAA 1 -- int10--------
    rs168706021,2
    C,F--72863756(+) AAGTAC/TGTGGT 1 -- int15Minor allele frequency- T:0.02NA WA 262
    rs749785011,2
    C--72863824(+) CTCAAC/TAGCTG 1 -- int10--------
    rs1121903201,2
    F--72863847(+) GGGGTG/ATGGCT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1466031631,2
    --72863867(+) TATGTG/TTATTT 1 -- int10--------
    rs1682231,2
    C,F,O,H--72863894(+) AGTCTG/AGGTGA 1 -- int122Minor allele frequency- A:0.11NS EA NA CSA WA 2486
    rs1858411011,2
    C--72863946(+) AAATAC/TAACTT 1 -- int10--------
    rs68981641,2
    C,F,H--72864007(+) TGCATA/GAATAG 1 -- int112Minor allele frequency- G:0.06NS EA NA CSA WA 1314

    HapMap Linkage Disequilibrium report for UTP15 (72861268 - 72877794 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for UTP15:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830346CNV Loss17160897
    nsv830347CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UTP15
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for UTP15:    
    About MalaCards
    exostosis    malaria

    1 disease from the University of Copenhagen DISEASES database for UTP15:
    Exostosis

    UTP15 for disorders           About GeneDecksing


    Export disorders for UTP15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UTP15 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with UTP15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    10. NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing. (PubMed id 22916032)2 Freed E.F....Baserga S.J. (PLoS Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84135 HGNC: 25758 AceView: FLJ12787 Ensembl:ENSG00000164338 euGenes: HUgn84135
    ECgene: UTP15 Kegg: 84135 H-InvDB: UTP15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UTP15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for UTP15 gene:
    Search GeneIP for patents involving UTP15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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