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Aliases for UTP14C Gene

Aliases for UTP14C Gene

  • UTP14, U3 Small Nucleolar Ribonucleoprotein, Homolog C (Yeast) 2 3
  • KIAA0266 2 3 4
  • U3 Small Nucleolar RNA-Associated Protein 14 Homolog C 3
  • 2700066J21Rik 3
  • UTP14B 3

External Ids for UTP14C Gene

Previous HGNC Symbols for UTP14C Gene

  • KIAA0266

Previous GeneCards Identifiers for UTP14C Gene

  • GC13P050385
  • GC13P051402
  • GC13P051496
  • GC13P052586
  • GC13P033387
  • GC13P052599

Summaries for UTP14C Gene

GeneCards Summary for UTP14C Gene

UTP14C (UTP14, U3 Small Nucleolar Ribonucleoprotein, Homolog C (Yeast)) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. An important paralog of this gene is UTP14A.

UniProtKB/Swiss-Prot for UTP14C Gene

  • Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP14C Gene

Genomics for UTP14C Gene

Regulatory Elements for UTP14C Gene

Genomic Location for UTP14C Gene

52,024,691 bp from pter
52,033,600 bp from pter
8,910 bases
Plus strand

Genomic View for UTP14C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UTP14C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP14C Gene

Proteins for UTP14C Gene

  • Protein details for UTP14C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U3 small nucleolar RNA-associated protein 14 homolog C
    Protein Accession:
    Secondary Accessions:
    • Q5FWG3
    • Q92555

    Protein attributes for UTP14C Gene

    766 amino acids
    Molecular mass:
    87188 Da
    Quaternary structure:
    No Data Available
    • Encoded by an autosomal retrotransposed copy of the X-linked gene UTP14A. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis
    • Sequence=BAA13396.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for UTP14C Gene

Proteomics data for UTP14C Gene at MOPED

Post-translational modifications for UTP14C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UTP14C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UTP14C Gene

Domains for UTP14C Gene

Protein Domains for UTP14C Gene


Suggested Antigen Peptide Sequences for UTP14C Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UTP14 family.
  • Belongs to the UTP14 family.
genes like me logo Genes that share domains with UTP14C: view

No data available for Gene Families for UTP14C Gene

Function for UTP14C Gene

Molecular function for UTP14C Gene

UniProtKB/Swiss-Prot Function:
Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity).

Animal Model Products

CRISPR Products

miRNA for UTP14C Gene

miRTarBase miRNAs that target UTP14C

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP14C Gene

Localization for UTP14C Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP14C Gene

Nucleus, nucleolus.

Gene Ontology (GO) - Cellular Components for UTP14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IBA --
GO:0032040 small-subunit processome IBA --
genes like me logo Genes that share ontologies with UTP14C: view

No data available for Subcellular locations from COMPARTMENTS for UTP14C Gene

Pathways for UTP14C Gene

genes like me logo Genes that share pathways with UTP14C: view

Pathways by source for UTP14C Gene

1 KEGG pathway for UTP14C Gene

Interacting Proteins for UTP14C Gene

Gene Ontology (GO) - Biological Process for UTP14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
GO:0030490 maturation of SSU-rRNA IBA --
genes like me logo Genes that share ontologies with UTP14C: view

Transcripts for UTP14C Gene

mRNA/cDNA for UTP14C Gene

Alternative Splicing Database (ASD) splice patterns (SP) for UTP14C Gene

No ASD Table

Relevant External Links for UTP14C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UTP14C Gene

mRNA expression in normal human tissues for UTP14C Gene

Protein differential expression in normal tissues for UTP14C Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UTP14C Gene

mRNA Expression by UniProt/SwissProt for UTP14C Gene

Tissue specificity: Expressed in testis.
genes like me logo Genes that share expressions with UTP14C: view

Expression partners for UTP14C Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UTP14C Gene

Orthologs for UTP14C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UTP14C Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Utp14b 35
  • 77.01 (n)
  • 66.84 (a)
Utp14a 36
  • 75 (a)
Utp14b 36
  • 64 (a)
(Pan troglodytes)
Mammalia UTP14C 35
  • 99.3 (n)
  • 98.96 (a)
(Rattus norvegicus)
Mammalia LOC102551819 35
  • 77.66 (n)
  • 68.89 (a)
(Bos Taurus)
Mammalia UTP14A 36
  • 76 (a)
UTP14A 36
  • 76 (a)
(Canis familiaris)
Mammalia UTP14A 36
  • 79 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
(Gallus gallus)
Aves UTP14A 35
  • 57.62 (n)
  • 53.1 (a)
-- 36
  • 49 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia utp14a 35
  • 61.01 (n)
  • 54.72 (a)
(Danio rerio)
Actinopterygii Dr.16592 35
si:dkey-251i10.3 35
  • 56.89 (n)
  • 51.34 (a)
UTP14A 36
  • 44 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2505 35
fruit fly
(Drosophila melanogaster)
Insecta CG12301 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea F27C1.6 36
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP14 36
  • 21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7000 35
Species with no ortholog for UTP14C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTP14C Gene

Gene Tree for UTP14C (if available)
Gene Tree for UTP14C (if available)

Paralogs for UTP14C Gene

Paralogs for UTP14C Gene

(1) SIMAP similar genes for UTP14C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UTP14C: view

Variants for UTP14C Gene

Sequence variations from dbSNP and Humsavar for UTP14C Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs15878 -- 52,032,255(+) TGAGA(A/C/G/T)TTACT utr-variant-3-prime
rs1055040 -- 52,031,202(+) CTCAG(C/T)ACATT utr-variant-3-prime
rs1055041 -- 52,031,218(+) TAGTT(A/C/G)AGCCA utr-variant-3-prime
rs1055062 -- 52,033,033(+) GTAAA(C/T)TATAT utr-variant-3-prime
rs1060630 -- 52,033,735(-) CTGGT(G/T)TCTCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for UTP14C Gene

Variant ID Type Subtype PubMed ID
nsv900082 CNV Gain 21882294

Relevant External Links for UTP14C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTP14C Gene

Disorders for UTP14C Gene

No disorders were found for UTP14C Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for UTP14C Gene

Publications for UTP14C Gene

  1. UTP14c is a recently acquired retrogene associated with spermatogenesis and fertility in man. (PMID: 16354793) Rohozinski J. … Bishop C.E. (Biol. Reprod. 2006) 2 3 23
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  4. The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b. (PMID: 15289605) Rohozinski J. … Bishop C.E. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for UTP14C Gene

Sources for UTP14C Gene

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