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Aliases for UTP14C Gene

Aliases for UTP14C Gene

  • UTP14, Small Subunit Processome Component Homolog C (S. Cerevisiae) 2 3
  • KIAA0266 2 3 4
  • UTP14, U3 Small Nucleolar Ribonucleoprotein, Homolog C (Yeast) 2 5
  • UTP14, U3 Small Nucleolar Ribonucleoprotein, Homolog C 3
  • 2700066J21Rik 3
  • UTP14B 3

External Ids for UTP14C Gene

Previous HGNC Symbols for UTP14C Gene

  • KIAA0266

Previous GeneCards Identifiers for UTP14C Gene

  • GC13P050385
  • GC13P051402
  • GC13P051496
  • GC13P052586
  • GC13P033387
  • GC13P052599

Summaries for UTP14C Gene

GeneCards Summary for UTP14C Gene

UTP14C (UTP14, Small Subunit Processome Component Homolog C (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. An important paralog of this gene is UTP14A.

UniProtKB/Swiss-Prot for UTP14C Gene

  • Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP14C Gene

Genomics for UTP14C Gene

Regulatory Elements for UTP14C Gene

Genomic Location for UTP14C Gene

Chromosome:
13
Start:
52,024,691 bp from pter
End:
52,033,600 bp from pter
Size:
8,910 bases
Orientation:
Plus strand

Genomic View for UTP14C Gene

Genes around UTP14C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTP14C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTP14C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP14C Gene

Proteins for UTP14C Gene

  • Protein details for UTP14C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TAP6-UT14C_HUMAN
    Recommended name:
    U3 small nucleolar RNA-associated protein 14 homolog C
    Protein Accession:
    Q5TAP6
    Secondary Accessions:
    • Q5FWG3
    • Q92555

    Protein attributes for UTP14C Gene

    Size:
    766 amino acids
    Molecular mass:
    87188 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Encoded by an autosomal retrotransposed copy of the X-linked gene UTP14A. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.
    SequenceCaution:
    • Sequence=BAA13396.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for UTP14C Gene

Proteomics data for UTP14C Gene at MOPED

Post-translational modifications for UTP14C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UTP14C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UTP14C Gene

Domains & Families for UTP14C Gene

Protein Domains for UTP14C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UTP14C Gene

Graphical View of Domain Structure for InterPro Entry

Q5TAP6

UniProtKB/Swiss-Prot:

UT14C_HUMAN :
  • Belongs to the UTP14 family.
Family:
  • Belongs to the UTP14 family.
genes like me logo Genes that share domains with UTP14C: view

No data available for Gene Families for UTP14C Gene

Function for UTP14C Gene

Molecular function for UTP14C Gene

UniProtKB/Swiss-Prot Function:
Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity).
genes like me logo Genes that share phenotypes with UTP14C: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP14C Gene

Localization for UTP14C Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP14C Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UTP14C Gene COMPARTMENTS Subcellular localization image for UTP14C gene
Compartment Confidence
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for UTP14C Gene

Pathways & Interactions for UTP14C Gene

genes like me logo Genes that share pathways with UTP14C: view

Pathways by source for UTP14C Gene

1 KEGG pathway for UTP14C Gene

Interacting Proteins for UTP14C Gene

Gene Ontology (GO) - Biological Process for UTP14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030490 maturation of SSU-rRNA IBA --
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with UTP14C: view

No data available for SIGNOR curated interactions for UTP14C Gene

Drugs & Compounds for UTP14C Gene

No Compound Related Data Available

Transcripts for UTP14C Gene

mRNA/cDNA for UTP14C Gene

(1) REFSEQ mRNAs :
(187) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for UTP14C Gene

No ASD Table

Relevant External Links for UTP14C Gene

GeneLoc Exon Structure for
UTP14C
ECgene alternative splicing isoforms for
UTP14C

Expression for UTP14C Gene

mRNA expression in normal human tissues for UTP14C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UTP14C Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UTP14C Gene



mRNA Expression by UniProt/SwissProt for UTP14C Gene

Q5TAP6-UT14C_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with UTP14C: view

Protein tissue co-expression partners for UTP14C Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UTP14C Gene

Orthologs for UTP14C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UTP14C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTP14C 35
  • 99.3 (n)
  • 98.96 (a)
cow
(Bos Taurus)
Mammalia UTP14A 36
  • 76 (a)
ManyToMany
UTP14A 36
  • 76 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia UTP14A 36
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Utp14b 16
Utp14a 36
  • 75 (a)
ManyToMany
Utp14b 36
  • 64 (a)
ManyToMany
Utp14b 35
  • 77.01 (n)
  • 66.84 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC102551819 35
  • 77.66 (n)
  • 68.89 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 49 (a)
OneToMany
UTP14A 35
  • 57.62 (n)
  • 53.1 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia utp14a 35
  • 61.01 (n)
  • 54.72 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2505 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16592 35
si:dkey-251i10.3 35
  • 56.89 (n)
  • 51.34 (a)
UTP14A 36
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12301 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F27C1.6 36
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP14 36
  • 21 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7000 35
Species with no ortholog for UTP14C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UTP14C Gene

ENSEMBL:
Gene Tree for UTP14C (if available)
TreeFam:
Gene Tree for UTP14C (if available)

Paralogs for UTP14C Gene

Paralogs for UTP14C Gene

(1) SIMAP similar genes for UTP14C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UTP14C: view

Variants for UTP14C Gene

Sequence variations from dbSNP and Humsavar for UTP14C Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_022812 -
VAR_022813 -
VAR_051482 -
rs15878 -- 52,032,255(+) TGAGA(A/C/G/T)TTACT utr-variant-3-prime
rs1055062 -- 52,033,033(+) GTAAA(C/T)TATAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UTP14C Gene

Variant ID Type Subtype PubMed ID
nsv900082 CNV Gain 21882294

Variation tolerance for UTP14C Gene

Residual Variation Intolerance Score: 84.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTP14C Gene

HapMap Linkage Disequilibrium report
UTP14C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTP14C Gene

Disorders for UTP14C Gene

Relevant External Links for UTP14C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTP14C

No disorders were found for UTP14C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTP14C Gene

Publications for UTP14C Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 67
  2. UTP14c is a recently acquired retrogene associated with spermatogenesis and fertility in man. (PMID: 16354793) Rohozinski J. … Bishop C.E. (Biol. Reprod. 2006) 2 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Does expression of the retrogene UTP14c in the ovary pre-dispose women to ovarian cancer? (PMID: 22285623) Rohozinski J. … Anderson M.L. (Med. Hypotheses 2012) 3

Products for UTP14C Gene

Sources for UTP14C Gene

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