UTP14C Gene
protein-coding GIFtS: 39
GCID: GC13P052599
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UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)(Previous name: KIAA0266 )
(Previous symbol: KIAA0266)
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Aliases
for UTP14C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| UTP14, U3 Small Nucleolar Ribonucleoprotein, Homolog C (Yeast)1 2 | | KIAA02661 2 3 | | 2700066J21Rik1 2 | | UTP14B2 | | U3 Small Nucleolar RNA-Associated Protein 14 Homolog C2 |
Export aliases for UTP14C gene to outside databasesPrevious GC identifers: GC13P050385 GC13P051402 GC13P051496 GC13P052586 GC13P033387 |
Summaries
for UTP14C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UT14C_HUMAN, Q5TAP6Function: Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence proteinsynthesis during male meiosis (By similarity)
|
Genomic Views
for UTP14C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UTP14C gene promoter:
ISGF-3 Sp1 p53 NRSF form 2 C/EBPalpha GATA-1 CHOP-10 COMP1 MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for UTP14C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UTP14C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.2 Ensembl cytogenetic band: 13q14.3 HGNC cytogenetic band: 13q12.2-q13.3UTP14C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P052599: view genomic region
(about GC identifiers)
Start:
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52,598,827 bp from pter |
End:
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52,607,736 bp from pter |
Size:
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8,910 bases |
Orientation:
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plus strand |
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Proteins
for UTP14C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UT14C_HUMAN, Q5TAP6 (See
protein sequence)Recommended Name: U3 small nucleolar RNA-associated protein 14 homolog C Size: 766 amino acids; 87188 Da
Subcellular location: Nucleus, nucleolus (By similarity)
Miscellaneous: Encoded by an autosomal retrotransposed copy of the X-linked gene UTP14A. Evolution of autosomalretrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis
Sequence caution: Sequence=BAA13396.2; Type=Erroneous initiation;
Secondary accessions: Q5FWG3 Q92555Explore the universe of human proteins at neXtProt for UTP14C: NX_Q5TAP6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TAP6
UTP14C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_067677.4
ENSEMBL proteins: ENSP00000428619
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
IEA | -- | | GO:0032040 | small-subunit processome |
IEA | -- |
UTP14C for ontologies About GeneDecksing
UTP14C Antibody Products:
Assay Products for UTP14C: |
Protein
Domains /
Families
for UTP14C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UTP14C for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5TAP6ProtoNet protein and cluster: Q5TAP6 UniProtKB/Swiss-Prot: UT14C_HUMAN, Q5TAP6Similarity: Belongs to the UTP14 family |
Function
for UTP14C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UT14C_HUMAN, Q5TAP6Function: Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence proteinsynthesis during male meiosis (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UTP14C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UTP14C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for UTP14C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTP14C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTP14C |
|
Pathways & Interactions
for UTP14C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ribosome biogenesis in eukaryotes | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for UTP14C):
UTP14C for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UTP14C
2 Interacting proteins for UTP14C (Q5TAP63) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
UTP14C for ontologies About GeneDecksing
|
Drugs & Compounds
for UTP14C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UTP14C
Search CenterWatch for drugs/clinical trials and news about UTP14C / UT14C
|
Transcripts
for UTP14C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UTP14C gene: NM_021645.5 1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000521776(uc001vga.3 uc001vgb.3 uc001vgc.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UTP14C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UTP14C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UTP14C (NM_021645) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UTP14C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTP14C |
24/187 AceView cDNA sequences (see all 187): AA442866 BM479135 NM_001004127 AL708143 BC073862 BM023472 AU132282 AW271597 CR602797 BC010857 BX369206 AI206392 AA954436 BX473993 BP373026 AA812710 AA781748 R63305 AA354152 AI221849 BX953947 N42423 AA709377 F05368
GeneLoc Exon Structure
|
Expression
for UTP14C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UTP14C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See UTP14C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UTP14C
UniProtKB/Swiss-Prot: UT14C_HUMAN, Q5TAP6Tissue specificity: Expressed in testis
SABiosciences Custom PCR Arrays for UTP14C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UTP14C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat UTP14C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UTP14C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UTP14C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTP14C |
Orthologs
for UTP14C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UTP14C gene from 7/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
UTP14A6 |
Uncharacterized protein |
58(a) |
1 → many |
4(1606880-1609299) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
45(a) |
1 → many |
GL343451.1(410954-422466) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.165922 |
Danio rerio, clone IMAGE2601678, mRNA, partial cds |
75.33(n) |
|
BC045321.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG123016 |
-- |
25(a) |
1 → many |
3L(15573900-15576473) |
worm
(Caenorhabditis elegans) |
Secernentea |
F27C1.66 |
Protein F27C1.6 |
22(a) |
1 → many |
I(5421292-5428460) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT4G024006AT5G086006 |
U3 ribonucleoprotein (Utp) family protein |
18(a)17(a) |
many ↔ manymany ↔ many |
4(1054199-1057998) 5(2786187-2790241) |
rice
(Oryza sativa) |
Liliopsida |
-- |
utp14 protein, putative, expressed |
17(a) |
1 → many |
3(12787096-12792139) |
ENSEMBL Gene Tree for UTP14C (if available)
TreeFam Gene Tree for UTP14C (if available) |
Paralogs
for UTP14C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UTP14C gene
- UTP14A2
1 SIMAP similar gene for UTP14C using alignment to 2 protein entries: UT14C_HUMAN (see all proteins):UTP14A
UTP14C for paralogs About GeneDecksing
|
Genomic Variants
for UTP14C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UTP14C (52598827 - 52607736 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UTP14C: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for UTP14C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 UTP14C for disorders About MalaCards
UTP14C for disorders About GeneDecksing
OMIM gene information: 608969
OMIM disorders: --
Export disorders for UTP14C gene to outside databases
|
Publications
for UTP14C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UTP14C gene integrated from 9 sources:
(articles sorted by number of sources associating them with UTP14C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2, 3 Nagase T....Nomura N. (1996)
- UTP14c is a recently acquired retrogene associated with spermatogenesis and fertility in man. (PubMed id 16354793)1, 3, 9 Rohozinski J....Bishop C.E. (2006)
- The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b. (PubMed id 15289605)1, 2 Rohozinski J. and Bishop C.E. (2004)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Does expression of the retrogene UTP14c in the ovary p re-dispose women to ovarian cancer? (PubMed id 22285623)1 Rohozinski J....Anderson M.L. (2012)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)1 Hillier L.D....Marra M. (1996)
|
External Searches for UTP14C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UTP14C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UTP14C gene
(According to HUGE)
About This Section
| |
Specialized Databases showing UTP14C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UTP14C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UTP14C gene:
Search GeneIP for patents involving UTP14C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UTP14C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UTP14C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UTP14C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UTP14C | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for UTP14C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UTP14C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UTP14C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UTP14C | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UTP14C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UTP14C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UTP14C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UTP14C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UTP14C |
| |
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| | | | Search Tocris compounds for UTP14C |
| |  |  |  |  | | | | |
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 | | | UTP14C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTP14C |
|  |  |  | | | | Search ThermoFisher Antibodies for UTP14C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTP14C |
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