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Aliases for UTP14A Gene

Aliases for UTP14A Gene

  • UTP14A Small Subunit Processome Component 2 3 5
  • Serologically Defined Colon Cancer Antigen 16 2 3 4
  • Antigen NY-CO-16 3 4
  • SDCCAG16 3 4
  • UTP14, U3 Small Nucleolar Ribonucleoprotein, Homolog A (Yeast) 2
  • U3 Small Nucleolar RNA-Associated Protein 14 Homolog A 3
  • UTP14, U3 Small Nucleolar Ribonucleoprotein, Homolog A 3
  • UTP14A Small Subunit (SSU) Processome Component 3
  • DJ537K23.3 3
  • NYCO16 3

External Ids for UTP14A Gene

Previous HGNC Symbols for UTP14A Gene

  • SDCCAG16

Previous GeneCards Identifiers for UTP14A Gene

  • GC0XP127746
  • GC0XP128765
  • GC0XP128867
  • GC0XP129040
  • GC0XP118440

Summaries for UTP14A Gene

Entrez Gene Summary for UTP14A Gene

  • This gene encodes a member of the uridine triphosphate 14 family. As an essential component of a large ribonucleoprotein complex bound to the U3 small nucleolar RNA, the encoded protein is involved in ribosome biogenesis and 18S rRNA synthesis. An autosomal retrotransposed copy of this X-linked gene exists on chromosome 13. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for UTP14A Gene

UTP14A (UTP14A Small Subunit Processome Component) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is UTP14C.

UniProtKB/Swiss-Prot for UTP14A Gene

  • May be required for ribosome biogenesis.

Gene Wiki entry for UTP14A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP14A Gene

Genomics for UTP14A Gene

Regulatory Elements for UTP14A Gene

Enhancers for UTP14A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG129770 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -126.4 -126363 17.9 HDGF PKNOX1 FOXA2 ZFP64 SIN3A YY1 TCF12 ZNF766 GATA2 ELK1 BCORL1 SASH3 XPNPEP2 UTP14A ELF4 ENSG00000240143 ZDHHC9 RBMX2
GH0XG129767 1.3 Ensembl ENCODE dbSUPER 12.1 -136.9 -136889 2.5 USF1 MAX POLR2A EED CHD2 MAZ MTA2 CBFB BHLHE40 NRF1 XPNPEP2 UTP14A RBMX2 SASH3
GH0XG129876 0.9 Ensembl ENCODE 13.9 -28.8 -28827 0.6 ELF3 SOX5 FOXA2 TEAD1 JUN TEAD3 JUND FOSL2 FOS UTP14A ZDHHC9 SALL4P2
GH0XG129635 1 Ensembl ENCODE 12.3 -269.5 -269495 2.7 ZNF263 CTCF ZNF654 TAL1 HLF TRIM22 REST RAD21 ZNF692 IKZF1 UTP14A XPNPEP2 APLN OCRL
GH0XG129607 1 Ensembl ENCODE 12.1 -299.0 -299015 0.2 CTCF ZNF654 KLF1 TRIM22 REST RAD21 ZNF366 ZNF143 U2AF1 SMC3 XPNPEP2 APLN ZDHHC9 UTP14A OCRL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UTP14A on UCSC Golden Path with GeneCards custom track

Promoters for UTP14A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000248675 180 1800 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A DMAP1 BRCA1 YY1 ETS1 GLIS2

Genomic Location for UTP14A Gene

Chromosome:
X
Start:
129,906,121 bp from pter
End:
129,929,762 bp from pter
Size:
23,642 bases
Orientation:
Plus strand

Genomic View for UTP14A Gene

Genes around UTP14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTP14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTP14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP14A Gene

Proteins for UTP14A Gene

  • Protein details for UTP14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVJ6-UT14A_HUMAN
    Recommended name:
    U3 small nucleolar RNA-associated protein 14 homolog A
    Protein Accession:
    Q9BVJ6
    Secondary Accessions:
    • A8K7A3
    • A8MVQ1
    • B4DQ08
    • E9PEL7
    • Q5JYF1

    Protein attributes for UTP14A Gene

    Size:
    771 amino acids
    Molecular mass:
    87978 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The human genome also contains the UTP14C gene, an autosomal retrotransposed copy of this X-linked gene. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.
    SequenceCaution:
    • Sequence=CAI42909.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for UTP14A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UTP14A Gene

Post-translational modifications for UTP14A Gene

Other Protein References for UTP14A Gene

No data available for DME Specific Peptides for UTP14A Gene

Domains & Families for UTP14A Gene

Protein Domains for UTP14A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UTP14A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BVJ6

UniProtKB/Swiss-Prot:

UT14A_HUMAN :
  • Belongs to the UTP14 family.
Family:
  • Belongs to the UTP14 family.
genes like me logo Genes that share domains with UTP14A: view

No data available for Gene Families for UTP14A Gene

Function for UTP14A Gene

Molecular function for UTP14A Gene

UniProtKB/Swiss-Prot Function:
May be required for ribosome biogenesis.

Gene Ontology (GO) - Molecular Function for UTP14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 15383276
genes like me logo Genes that share ontologies with UTP14A: view
genes like me logo Genes that share phenotypes with UTP14A: view

Animal Model Products

CRISPR Products

miRNA for UTP14A Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP14A Gene

Localization for UTP14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP14A Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTP14A gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for UTP14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IDA --
GO:0032040 small-subunit processome IBA --
genes like me logo Genes that share ontologies with UTP14A: view

Pathways & Interactions for UTP14A Gene

genes like me logo Genes that share pathways with UTP14A: view

Gene Ontology (GO) - Biological Process for UTP14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0030490 maturation of SSU-rRNA IBA --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with UTP14A: view

No data available for SIGNOR curated interactions for UTP14A Gene

Drugs & Compounds for UTP14A Gene

No Compound Related Data Available

Transcripts for UTP14A Gene

Unigene Clusters for UTP14A Gene

UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTP14A Gene

No ASD Table

Relevant External Links for UTP14A Gene

GeneLoc Exon Structure for
UTP14A
ECgene alternative splicing isoforms for
UTP14A

Expression for UTP14A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UTP14A Gene

Protein differential expression in normal tissues from HIPED for UTP14A Gene

This gene is overexpressed in Liver, secretome (13.4), CD8 Tcells (11.0), Peripheral blood mononuclear cells (10.2), Pancreas (8.5), and Blymphocyte (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UTP14A Gene



Protein tissue co-expression partners for UTP14A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UTP14A Gene:

UTP14A

SOURCE GeneReport for Unigene cluster for UTP14A Gene:

Hs.458598

mRNA Expression by UniProt/SwissProt for UTP14A Gene:

Q9BVJ6-UT14A_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for UTP14A Gene

  • Liver(4.3)
  • Muscle(4.3)
  • Eye(4.1)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with UTP14A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UTP14A Gene

Orthologs for UTP14A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UTP14A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTP14A 34 35
  • 96.75 (n)
dog
(Canis familiaris)
Mammalia UTP14A 34 35
  • 86.68 (n)
cow
(Bos Taurus)
Mammalia UTP14A 34 35 35
  • 85.31 (n)
mouse
(Mus musculus)
Mammalia Utp14a 34 16 35
  • 82.11 (n)
Utp14b 35
  • 67 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Utp14a 34
  • 81.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 59 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 54 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii UTP14A 35
  • 45 (a)
OneToMany
Dr.16121 34
fruit fly
(Drosophila melanogaster)
Insecta CG12301 35
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F27C1.6 34 35
  • 47.57 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP14 35
  • 23 (a)
OneToMany
Species where no ortholog for UTP14A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UTP14A Gene

ENSEMBL:
Gene Tree for UTP14A (if available)
TreeFam:
Gene Tree for UTP14A (if available)

Paralogs for UTP14A Gene

Paralogs for UTP14A Gene

(1) SIMAP similar genes for UTP14A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UTP14A: view

Variants for UTP14A Gene

Sequence variations from dbSNP and Humsavar for UTP14A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000148586 -- 129,918,684(+) CATCC(C/T)GGCTA intron-variant
rs1000200316 -- 129,914,143(+) TTATG(C/T)TAGTA intron-variant
rs1000252682 -- 129,914,525(+) TGAGC(C/T)GAGAT intron-variant
rs1000357700 -- 129,924,016(+) GCAGT(A/G)GCACA intron-variant
rs1000537632 -- 129,912,398(+) ATTAC(A/C/G)GGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UTP14A Gene

Variant ID Type Subtype PubMed ID
nsv1112507 CNV deletion 24896259
nsv528290 CNV gain 19592680

Variation tolerance for UTP14A Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTP14A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTP14A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTP14A Gene

Disorders for UTP14A Gene

Relevant External Links for UTP14A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTP14A

No disorders were found for UTP14A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTP14A Gene

Publications for UTP14A Gene

  1. A small ribosomal subunit (SSU) processome component, the human U3 protein 14A (hUTP14A) binds p53 and promotes p53 degradation. (PMID: 21078665) Hu L. … Ke Y. (J. Biol. Chem. 2011) 2 3 64
  2. UTP14c is a recently acquired retrogene associated with spermatogenesis and fertility in man. (PMID: 16354793) Rohozinski J. … Bishop C.E. (Biol. Reprod. 2006) 2 3 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for UTP14A Gene

Sources for UTP14A Gene

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