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Aliases for UTP14A Gene

Aliases for UTP14A Gene

  • UTP14A Small Subunit Processome Component 2 3 5
  • Serologically Defined Colon Cancer Antigen 16 2 3 4
  • Antigen NY-CO-16 3 4
  • SDCCAG16 3 4
  • UTP14, U3 Small Nucleolar Ribonucleoprotein, Homolog A (Yeast) 2
  • UTP14, U3 Small Nucleolar Ribonucleoprotein, Homolog A 3
  • UTP14A Small Subunit (SSU) Processome Component 3
  • DJ537K23.3 3
  • NYCO16 3

External Ids for UTP14A Gene

Previous HGNC Symbols for UTP14A Gene

  • SDCCAG16

Previous GeneCards Identifiers for UTP14A Gene

  • GC0XP127746
  • GC0XP128765
  • GC0XP128867
  • GC0XP129040
  • GC0XP118440

Summaries for UTP14A Gene

Entrez Gene Summary for UTP14A Gene

  • This gene encodes a member of the uridine triphosphate 14 family. As an essential component of a large ribonucleoprotein complex bound to the U3 small nucleolar RNA, the encoded protein is involved in ribosome biogenesis and 18S rRNA synthesis. An autosomal retrotransposed copy of this X-linked gene exists on chromosome 13. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for UTP14A Gene

UTP14A (UTP14A Small Subunit Processome Component) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is UTP14C.

UniProtKB/Swiss-Prot for UTP14A Gene

  • May be required for ribosome biogenesis.

Gene Wiki entry for UTP14A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTP14A Gene

Genomics for UTP14A Gene

Regulatory Elements for UTP14A Gene

Enhancers for UTP14A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UTP14A on UCSC Golden Path with GeneCards custom track

Promoters for UTP14A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UTP14A on UCSC Golden Path with GeneCards custom track

Genomic Location for UTP14A Gene

129,906,121 bp from pter
129,929,762 bp from pter
23,642 bases
Plus strand

Genomic View for UTP14A Gene

Genes around UTP14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTP14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTP14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTP14A Gene

Proteins for UTP14A Gene

  • Protein details for UTP14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U3 small nucleolar RNA-associated protein 14 homolog A
    Protein Accession:
    Secondary Accessions:
    • A8K7A3
    • A8MVQ1
    • B4DQ08
    • E9PEL7
    • Q5JYF1

    Protein attributes for UTP14A Gene

    771 amino acids
    Molecular mass:
    87978 Da
    Quaternary structure:
    No Data Available
    • The human genome also contains the UTP14C gene, an autosomal retrotransposed copy of this X-linked gene. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.
    • Sequence=CAI42909.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for UTP14A Gene


neXtProt entry for UTP14A Gene

Proteomics data for UTP14A Gene at MOPED

Post-translational modifications for UTP14A Gene

Other Protein References for UTP14A Gene

Antibody Products

No data available for DME Specific Peptides for UTP14A Gene

Domains & Families for UTP14A Gene

Protein Domains for UTP14A Gene


Suggested Antigen Peptide Sequences for UTP14A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UTP14 family.
  • Belongs to the UTP14 family.
genes like me logo Genes that share domains with UTP14A: view

No data available for Gene Families for UTP14A Gene

Function for UTP14A Gene

Molecular function for UTP14A Gene

UniProtKB/Swiss-Prot Function:
May be required for ribosome biogenesis.

Gene Ontology (GO) - Molecular Function for UTP14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with UTP14A: view
genes like me logo Genes that share phenotypes with UTP14A: view

Animal Model Products

miRNA for UTP14A Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UTP14A Gene

Localization for UTP14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTP14A Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for UTP14A Gene COMPARTMENTS Subcellular localization image for UTP14A gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for UTP14A Gene

Pathways & Interactions for UTP14A Gene

genes like me logo Genes that share pathways with UTP14A: view

Pathways by source for UTP14A Gene

Gene Ontology (GO) - Biological Process for UTP14A Gene


No data available for SIGNOR curated interactions for UTP14A Gene

Drugs & Compounds for UTP14A Gene

No Compound Related Data Available

Transcripts for UTP14A Gene

Unigene Clusters for UTP14A Gene

UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UTP14A Gene

No ASD Table

Relevant External Links for UTP14A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UTP14A Gene

mRNA expression in normal human tissues for UTP14A Gene

Protein differential expression in normal tissues from HIPED for UTP14A Gene

This gene is overexpressed in Liver, secretome (13.4), CD8 Tcells (11.0), Peripheral blood mononuclear cells (10.2), Pancreas (8.5), and Blymphocyte (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UTP14A Gene

SOURCE GeneReport for Unigene cluster for UTP14A Gene Hs.458598

mRNA Expression by UniProt/SwissProt for UTP14A Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with UTP14A: view

Protein tissue co-expression partners for UTP14A Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UTP14A Gene

Orthologs for UTP14A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UTP14A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UTP14A 35
  • 85.31 (n)
  • 79.92 (a)
UTP14A 36
  • 79 (a)
UTP14A 36
  • 79 (a)
(Canis familiaris)
Mammalia UTP14A 35
  • 86.68 (n)
  • 83.57 (a)
UTP14A 36
  • 83 (a)
(Mus musculus)
Mammalia Utp14a 35
  • 82.11 (n)
  • 77.75 (a)
Utp14a 16
Utp14a 36
  • 77 (a)
Utp14b 36
  • 67 (a)
(Pan troglodytes)
Mammalia UTP14A 35
  • 96.75 (n)
  • 95.97 (a)
UTP14A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Utp14a 35
  • 81.74 (n)
  • 77.59 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
(Gallus gallus)
Aves -- 36
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
(Danio rerio)
Actinopterygii Dr.16121 35
UTP14A 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12301 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea F27C1.6 35
  • 47.57 (n)
  • 38.02 (a)
F27C1.6 36
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP14 36
  • 23 (a)
Species with no ortholog for UTP14A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for UTP14A Gene

Gene Tree for UTP14A (if available)
Gene Tree for UTP14A (if available)

Paralogs for UTP14A Gene

Paralogs for UTP14A Gene

(1) SIMAP similar genes for UTP14A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UTP14A: view

Variants for UTP14A Gene

Sequence variations from dbSNP and Humsavar for UTP14A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_022811 -
VAR_069181 -
rs757944535 -- 129,919,155(+) CAGAA(-/TGTTTTGT)TGCTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UTP14A Gene

Variant ID Type Subtype PubMed ID
nsv528290 CNV Gain 19592680

Variation tolerance for UTP14A Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UTP14A Gene

Disorders for UTP14A Gene

Relevant External Links for UTP14A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UTP14A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTP14A Gene

Publications for UTP14A Gene

  1. A small ribosomal subunit (SSU) processome component, the human U3 protein 14A (hUTP14A) binds p53 and promotes p53 degradation. (PMID: 21078665) Hu L. … Ke Y. (J. Biol. Chem. 2011) 2 3 67
  2. UTP14c is a recently acquired retrogene associated with spermatogenesis and fertility in man. (PMID: 16354793) Rohozinski J. … Bishop C.E. (Biol. Reprod. 2006) 2 3
  3. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan M.J. … Old L.J. (Int. J. Cancer 1998) 2 3
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  5. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3

Products for UTP14A Gene

Sources for UTP14A Gene