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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UTF1 Gene

protein-coding   GIFtS: 52
GCID: GC10P135043

Undifferentiated Embryonic Cell Transcription Factor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Undifferentiated Embryonic Cell Transcription Factor 11 2

External Ids:    HGNC: 126341   Entrez Gene: 84332   Ensembl: ENSG000001717947   OMIM: 6041305   UniProtKB: Q5T2303   

Export aliases for UTF1 gene to outside databases

Previous GC identifers: GC10P133958 GC10P134173 GC10P134959 GC10P134517 GC10P134932 GC10P128590


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UTF1 Gene: 
UTF1 (undifferentiated embryonic cell transcription factor 1) is a protein-coding gene. Diseases associated with UTF1 include teratoma, and teratocarcinoma, and among its related super-pathways are Factors Promoting Cardiogenesis in Vertebrates. GO annotations related to this gene include transcription coactivator activity and HMG box domain binding.

UniProtKB/Swiss-Prot: UTF1_HUMAN, Q5T230
Function: Acts as a transcriptional coactivator of ATF2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_008818.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UTF1 gene promoter:
         AhR   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUTF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for UTF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UTF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26

UTF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UTF1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P135043:  view genomic region     (about GC identifiers)

Start:
135,043,778 bp from pter      End:
135,045,062 bp from pter
Size:
1,285 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UTF1_HUMAN, Q5T230 (See protein sequence)
Recommended Name: Undifferentiated embryonic cell transcription factor 1  
Size: 341 amino acids; 36439 Da
Subunit: Binds to the N-terminal region of ATF2. Associates with the TFIID complex through interaction with TBP
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAT38949.1; Type=Erroneous initiation;
Secondary accessions: O75833 Q6J1H3

Explore the universe of human proteins at neXtProt for UTF1: NX_Q5T230

Explore proteomics data for UTF1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5T230

  • UTF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UTF1 Protein Expression
    REFSEQ proteins: NP_003568.2  
    ENSEMBL proteins: 
     ENSP00000305906  

    Human Recombinant Protein Products for UTF1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for UTF1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for UTF1
    GenScript Custom Purified and Recombinant Proteins Services for UTF1
    Novus Biologicals UTF1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UTF1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18281244

    UTF1 for ontologies           About GeneDecksing



    UTF1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of UTF1
    R&D Systems Antibodies for UTF1
    Cell Signaling Technology (CST) Antibodies for UTF1 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UTF1
    GenScript Custom Superior Antibodies Services for UTF1
    Novus Biologicals UTF1 Antibody
    Abcam antibodies for UTF1
    Cloud-Clone Corp. Antibodies for UTF1 
    ThermoFisher Antibody for UTF1
    LSBio Antibodies in human, mouse, rat for UTF1 

    Assay Products for UTF1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UTF1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UTF1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UTF1 
    Cloud-Clone Corp. CLIAs for UTF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026651 UTF1

    Graphical View of Domain Structure for InterPro Entry Q5T230

    ProtoNet protein and cluster: Q5T230

    UniProtKB/Swiss-Prot: UTF1_HUMAN, Q5T230
    Domain: The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein
    is able to stimulate transcription from a number of gene promoters (By similarity)


    UTF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UTF1_HUMAN, Q5T230
    Function: Acts as a transcriptional coactivator of ATF2

         Genatlas biochemistry entry for UTF1:
    undifferentiated embryonic cell transcription factor 1 from the mouse F9 teratocarcinoma cell
    line,homolog,potentiating ATF-2 (activating transcription factor)-2 activity

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA9748258
    GO:0005515protein binding IPI9748258
    GO:0071837HMG box domain binding IEA--
         
    UTF1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UTF1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UTF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UTF1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UTF1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UTF1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate UTF1
    SwitchGear 3'UTR luciferase reporter plasmidUTF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UTF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UTF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UTF1
    Sirion Biotech Customized adenovirus for overexpression of UTF1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for UTF1 (see all 6)
    OriGene ORF clones in mouse, rat for UTF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UTF1 (NM_003577)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UTF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTF1
    Sirion Biotech Customized lentivirus for stable overexpression of UTF1 
                         Customized lentivirus expression plasmids for stable overexpression of UTF1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UTF1
    Search LifeMap BioReagents cell lines for UTF1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTF1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UTF1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Human Embryonic Stem Cell Pluripotency
    Human Embryonic Stem Cell Pluripotency0.50
    2Selected targets of Oct-3/4
    Selected targets of Oct-3/4
    3Oct4 in Mammalian ESC Pluripotency
    Oct4 in Mammalian ESC Pluripotency
    4Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for UTF1
        Selected targets of Oct-3/4

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UTF1
        Oct4 in Mammalian ESC Pluripotency
    Human Embryonic Stem Cell Pluripotency

    1 Cell Signaling Technology (CST) Pathway for UTF1
        Wnt / Hedgehog / Notch



    UTF1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UTF1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for UTF1 (Q5T2303 ENSP000003059064) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF2P153363, ENSP000002641104I2D: score=3 STRING: ENSP00000264110
    SOX10P566933, ENSP000003541304I2D: score=2 STRING: ENSP00000354130
    SOX8P570733, ENSP000002938944I2D: score=1 STRING: ENSP00000293894
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9748258
    GO:0008584male gonad development IEP18281244
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA9748258

    UTF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UTF1

    Search CenterWatch for drugs/clinical trials and news about UTF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UTF1 gene: 
    NM_003577.2  

    Unigene Cluster for UTF1:

    Undifferentiated embryonic cell transcription factor 1
    Hs.458406
    Unigene Representative Sequence: AB011076
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304477(uc001lmc.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UTF1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate UTF1
    SwitchGear 3'UTR luciferase reporter plasmidUTF1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UTF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UTF1
    Clone
    Products:
         
    OriGene clones in human, mouse for UTF1 (see all 6)
    OriGene ORF clones in mouse, rat for UTF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UTF1 (NM_003577)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UTF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTF1
    Sirion Biotech Customized lentivirus for stable overexpression of UTF1 
                         Customized lentivirus expression plasmids for stable overexpression of UTF1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UTF1
    OriGene qSTAR qPCR primer pairs in human, mouse for UTF1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UTF1
      Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UTF1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UTF1

    Additional mRNA sequence: 

    AB011076.2 AY606112.1 

    1 DOTS entry:

    DT.91745164 

    3 AceView cDNA sequences:

    AY606112 NM_003577 AB011076 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UTF1 expression in normal human tissues (normalized intensities)      UTF1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTGCTGG
    UTF1 Expression
    About this image


    UTF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 10 entries
             Line H1 (WA01)
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Gonad
             XY Germ Cells Testis Cord
     
     Oral Cavity (Gastrointestinal Tract)
             saliva   

    See UTF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UTF1

    SOURCE GeneReport for Unigene cluster: Hs.458406
        SABiosciences Expression via Pathway-Focused PCR Array including UTF1: 
              Embryonic Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UTF1
    OriGene qSTAR qPCR primer pairs in human, mouse for UTF1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UTF1
    Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UTF1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UTF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for UTF1 gene from 1/2 species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Utf11 , 5 undifferentiated embryonic cell transcription factor more1, 5 69.49(n)1
    64.95(a)1
      7 (84.91 cM)5
    222861  NM_009482.21  NP_033508.11 
     1399437895 


    ENSEMBL Gene Tree for UTF1 (if available)
    TreeFam Gene Tree for UTF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/69 SNPs in UTF1 are shown (see all 69)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs29981121,2
    C,F,A--135041958(-) cccatG/Ctctgc 1 -- us2k111Minor allele frequency- C:0.44NA WA CSA EA 373
    rs1382368511,2
    --135042070(+) TATGAC/GTGCCT 1 -- us2k10--------
    rs1822655421,2
    --135042207(+) CAAGGA/GAGAGA 1 -- us2k10--------
    rs1872767971,2
    --135042209(+) AGGAAA/GAGAGG 1 -- us2k10--------
    rs124155901,2
    C,F,H--135042214(+) gagagG/Aaggag 1 -- us2k1 trp317Minor allele frequency- A:0.04NS EA NA 1704
    rs1907842811,2
    --135042236(+) TTCAAC/TGGCCA 1 -- us2k10--------
    rs1428418871,2
    C--135042281(+) AGCCCA/GGCACA 1 -- us2k10--------
    rs1171501601,2
    C,F--135042361(+) AAGACG/AAGCCT 1 -- us2k11Minor allele frequency- A:0.06NA 120
    rs1807927701,2
    --135042436(+) TGGTGA/GTGCAC 1 -- us2k10--------
    rs44697981,2
    C,F--135042528(+) caggcC/Tactgc 1 -- us2k12Minor allele frequency- T:0.03CSA WA 120

    HapMap Linkage Disequilibrium report for UTF1 (135043778 - 135045062 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/24 variations for UTF1 (see all 24):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv820950CNV Deletion20802225
    dgv2e196CNV Duplication17116639
    nsv832036CNV Loss17160897
    nsv896267CNV Loss21882294
    dgv879n71CNV Loss21882294
    nsv832039CNV Loss17160897
    dgv884n71CNV Loss21882294
    nsv896258CNV Loss21882294
    dgv882n71CNV Loss21882294
    dgv880n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): UTF1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UTF1
    DNA2.0 Custom Variant and Variant Library Synthesis for UTF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604130    OMIM disorders: --

    4 diseases for UTF1:    About MalaCards
    teratoma    teratocarcinoma    germ cell tumors    cervicitis

    2 diseases from the University of Copenhagen DISEASES database for UTF1:
    Teratoma     Embryonal carcinoma

    UTF1 for disorders           About GeneDecksing


    Export disorders for UTF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UTF1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with UTF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity. (PubMed id 9748258)1, 2, 3 Fukushima A....Muramatsu M. (1998)
    2. Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. (PubMed id 18281244)1, 3 Kristensen D.M....Leffers H. (2008)
    3. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    4. Undifferentiated embryonic cell transcription factor-1 (UTF1) inhibits the growth of cervical cancer cells by transactivating p27Kip1. (PubMed id 23536577)1 Wu X.L. and Zheng P.S. (2013)
    5. Regulation of pluripotency and self- renewal of ESCs t hrough epigenetic-threshold modulation and mRNA pruning. (PubMed id 23101626)1 Jia J....Zheng Y. (2012)
    6. Aberrant promoter methylation and expression of UTF1 d uring cervical carcinogenesis. (PubMed id 22880087)1 Guenin S....Delvenne P. (2012)
    7. Embryonic stem cell factors undifferentiated transcri ption factor-1 (UFT-1) and reduced expression protein-1 (REX-1) are widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination. (PubMed id 21446939)1 Reinisch C.M....Pammer J. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Expression of UTF1 in primary and metastatic testicul ar germ cell tumors. (PubMed id 20855642)1 Wang P....Cao D. (2010)
    10. Functional characterization of single-nucleotide poly morphisms in the human undifferentiated embryonic-cell transcription factor 1 g ene. (PubMed id 20218897)1 Thummer R.P....Eggen B.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8433 HGNC: 12634 AceView: UTF1 Ensembl:ENSG00000171794 euGenes: HUgn8433
    ECgene: UTF1 H-InvDB: UTF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UTF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UTF1 gene:
    Search GeneIP for patents involving UTF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of UTF1
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
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     Antibodies for UTF1 (UTF1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for UTF1  
     OriGene qPCR primer pairs and template standards for UTF1   OriGene Protein Over-expression Lysate for UTF1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for UTF1  
     OriGene qSTAR qPCR primer pairs in human, mouse for UTF1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for UTF1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UTF1   OriGene Custom Protein Services for UTF1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UTF1
     QIAGEN SeqTarget long-range PCR primers for resequencing UTF1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UTF1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UTF1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UTF1
     Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UTF1
     GenScript Custom Purified and Recombinant Proteins Services for UTF1 GenScript cDNA clones with any tag delivered in your preferred vector for UTF1
     GenScript Custom Assay Services for UTF1 GenScript Custom Superior Antibodies Services for UTF1
     GenScript Custom overexpressing Cell Line Services for UTF1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for UTF1 

     Regulatory tfbs in UTF1 promoter
     Search Chromatin IP Primers for UTF1
     RT2 qPCR Primer Assay in human, mouse, rat UTF1
     Search GNC Networks for UTF1
     SABiosciences PCR Arrays including human, mouse, rat UTF1
     Search Tocris compounds for UTF1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     UTF1 antibodies
     UTF1 lysates
     Antibodies for UTF1
     See all of Abcam's Antibodies, Kits and Proteins for UTF1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for UTF1
     Antibodies for UTF1
     ELISAs for UTF1
     CLIAs for UTF1
     Search LifeMap BioReagents cell lines for UTF1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTF1
     SwitchGear 3'UTR luciferase reporter plasmids for UTF1
     SwitchGear Promoter luciferase reporter plasmids for UTF1
     ThermoFisher Antibody for UTF1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTF1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for UTF1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UTF1
    Customized:
     lentivirus for stable overexpression of UTF1
     lentivirus expression plasmids for stable overexpression of UTF1
     adenovirus for overexpression of UTF1
     LSBio Antibodies in human, mouse, rat for UTF1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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