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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UTF1 Gene

protein-coding   GIFtS: 52
GCID: GC10P135043

undifferentiated embryonic cell transcription factor 1
 Explore 5 diseases affiliated with
UTF1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UTF1    

Aliases
for UTF1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Undifferentiated Embryonic Cell Transcription Factor 11 2

External Ids:    HGNC: 126341   Entrez Gene: 84332   Ensembl: ENSG000001717947   OMIM: 6041305   UniProtKB: Q5T2303   

Export aliases for UTF1 gene to outside databases

Previous GC identifers: GC10P133958 GC10P134173 GC10P134959 GC10P134517 GC10P134932 GC10P128590


Summaries
for UTF1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: UTF1_HUMAN, Q5T230
Function: Acts as a transcriptional coactivator of ATF2




Genomic Views
for UTF1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008818.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UTF1 gene promoter:
         AhR   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UTF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for UTF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UTF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26

UTF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UTF1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P135043:  view genomic region     (about GC identifiers)

Start:
 135,043,778 bp from pter      End:
 135,045,062 bp from pter
Size:
 1,285 bases      Orientation:
 plus strand

Proteins
for UTF1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UTF1_HUMAN, Q5T230 (See protein sequence)
Recommended Name: Undifferentiated embryonic cell transcription factor 1  
Size: 341 amino acids; 36439 Da
Subunit: Binds to the N-terminal region of ATF2. Associates with the TFIID complex through interaction with TBP
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAT38949.1; Type=Erroneous initiation;
Secondary accessions: O75833 Q6J1H3

Explore the universe of human proteins at neXtProt for UTF1: NX_Q5T230

Post-translational modifications:

  • Phosphorylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5T230

    • UTF1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003568.2  
    ENSEMBL proteins: 
     ENSP00000305906  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: UTF1
    OriGene Custom Protein Services for UTF1 
    GenScript Custom Purified and Recombinant Proteins Services for UTF1
    Novus Biologicals UTF1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UTF1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18281244


    UTF1 for ontologies           About GeneDecksing



    UTF1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of UTF1
    R&D Systems Antibodies for UTF1
    Cell Signaling Technology (CST) Antibodies for UTF1 
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    OriGene Custom Antibody Services for UTF1 
    GenScript Custom Superior Antibodies Services for UTF1
    Novus Biologicals UTF1 Antibody
    Abcam antibodies for UTF1 
    Uscn Antibodies for UTF1
    ThermoFisher Antibodies for UTF1

    Assay Products for UTF1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UTF1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for UTF1

    Protein Domains /
    Families
    for UTF1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UTF1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026651 UTF1

    Graphical View of Domain Structure for InterPro Entry Q5T230

    ProtoNet protein and cluster: Q5T230

    UniProtKB/Swiss-Prot: UTF1_HUMAN, Q5T230
    Domain: The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is
    able to stimulate transcription from a number of gene promoters (By similarity)


    Function
    for UTF1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UTF1_HUMAN, Q5T230
    Function: Acts as a transcriptional coactivator of ATF2

         Genatlas biochemistry entry for UTF1:
    undifferentiated embryonic cell transcription factor 1 from the mouse F9 teratocarcinoma cell line,homolog,potentiating
    ATF-2 (activating transcription factor)-2 activity

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UTF1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate UTF1
    SwitchGear 3'UTR luciferase reporter plasmid: UTF1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UTF1 (see all 7)
    OriGene shRNA RFP: UTF1
    OriGene siRNA: UTF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UTF1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for UTF1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UTF1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UTF1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: UTF1 (NM_003577)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UTF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTF1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for UTF1
    Search LifeMap BioReagents cell lines for UTF1

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for UTF1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA9748258
    GO:0005515protein binding IPI9748258
    GO:0071837HMG box domain binding IEA--


    UTF1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for UTF1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Selected targets of Oct-3/4
    		Selected targets of Oct-3/41.00
    2Oct4 in Mammalian ESC Pluripotency
    		Oct4 in Mammalian ESC Pluripotency1.00
    3Human Embryonic Stem Cell Pluripotency
    		Human Embryonic Stem Cell Pluripotency1.00
    4Wnt / Hedgehog / Notch
    		Wnt / Hedgehog / Notch1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for UTF1
        Selected targets of Oct-3/4

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UTF1
        Oct4 in Mammalian ESC Pluripotency
    Human Embryonic Stem Cell Pluripotency

    1 Cell Signaling Technology (CST) Pathway for UTF1
        Wnt / Hedgehog / Notch



    UTF1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UTF1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for UTF1 (Q5T2303 ENSP000003059064) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF2P153363, ENSP000002641104I2D: score=3 STRING: ENSP00000264110
    SOX10P566933, ENSP000003541304I2D: score=2 STRING: ENSP00000354130
    SOX8P570733, ENSP000002938944I2D: score=1 STRING: ENSP00000293894
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9748258
    GO:0008584male gonad development IEP18281244
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA9748258


    UTF1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for UTF1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UTF1
    Search CenterWatch for drugs/clinical trials and news about UTF1 

    Transcripts
    for UTF1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UTF1 gene: 
    NM_003577.2  

    Unigene Cluster for UTF1:

    Undifferentiated embryonic cell transcription factor 1
    Hs.458406
    Unigene Representative Sequence: AB011076
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304477(uc001lmc.3)

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UTF1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate UTF1
    SwitchGear 3'UTR luciferase reporter plasmid: UTF1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UTF1 (see all 7)
    OriGene shRNA RFP: UTF1
    OriGene siRNA: UTF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UTF1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UTF1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UTF1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: UTF1 (NM_003577)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UTF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTF1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UTF1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UTF1
      Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UTF1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UTF1

    Additional cDNA sequence: 

    AB011076.2 AY606112.1 

    1 DOTS entry:

    DT.91745164 

    3 AceView cDNA sequences:

    AY606112 AB011076 NM_003577 

    GeneLoc Exon Structure


    Expression
    for UTF1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UTF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGCTGCTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UTF1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 10 LifeMap Cells 
    NameCategory
    Induced pluripotent stem cell line 201B6 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    ESI-017 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    ESI-035 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    ESI-049 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    ESI-051 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    ESI-053 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    CyT203 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Line H1 (WA01) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See UTF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UTF1

    SOURCE GeneReport for Unigene cluster: Hs.458406
        SABiosciences Expression via Pathway-Focused PCR Array including UTF1: 
              Embryonic Stem Cells in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UTF1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UTF1
    Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UTF1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UTF1
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for UTF1

    Orthologs
    for UTF1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for UTF1 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Utf11 , 5 undifferentiated embryonic cell transcription factor more1, 5 69.49(n)1
    64.95(a)1    		   7 (84.91 cM)5
    222861  NM_009482.21  NP_033508.11 
     1399437895 


    ENSEMBL Gene Tree for UTF1 (if available)
    TreeFam Gene Tree for UTF1 (if available) 

    Paralogs
    for UTF1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for UTF1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/52 NCBI SNPs in UTF1 are shown (see all 52)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs29981121,2
    		C,F,A,--135041958(-) CCCATG/CTCTGC 1 -- us2k111Minor allele frequency- C:0.44NA WA CSA EA 373
    rs1382368511,2
    		--135042070(+) TATGAC/GTGCCT 1 -- us2k10--------
    rs1822655421,2
    		--135042207(+) CAAGGA/GAGAGA 1 -- us2k10--------
    rs1872767971,2
    		--135042209(+) AGGAAA/GAGAGG 1 -- us2k10--------
    rs124155901,2
    		C,F,H,--135042214(+) GAGAGG/AAGGAG 1 -- us2k1 trp317Minor allele frequency- A:0.04NS EA NA 1704
    rs1907842811,2
    		--135042236(+) TTCAAC/TGGCCA 1 -- us2k10--------
    rs1428418871,2
    		--135042281(+) AGCCCA/GGCACA 1 -- us2k10--------
    rs1171501601,2
    		F,--135042361(+) AAGACG/AAGCCT 1 -- us2k11Minor allele frequency- A:0.06NA 120
    rs1807927701,2
    		--135042436(+) TGGTGA/GTGCAC 1 -- us2k10--------
    rs44697981,2
    		--135042528(+) caggcC/Tactgc 1 -- us2k12Minor allele frequency- T:0.03CSA WA 120

    HapMap Linkage Disequilibrium report for UTF1 (135043778 - 135045062 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for UTF1
         9 CNVs: 2896 4723 4721 30525 5272 29879 4722 5273 3829
    Human Gene Mutation Database (HGMD): UTF1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UTF1
    DNA2.0 Custom Variant and Variant Library Synthesis for UTF1

    Disorders / Diseases
    for UTF1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UTF1 for disorders           About GeneDecksing

    OMIM gene information: 604130    OMIM disorders: --

    5 diseases for UTF1:    About MalaCards
    germ cell tumor    teratoma    embryonal carcinoma    teratocarcinoma
    carcinoma

    2 diseases from the University of Copenhagen DISEASES database for UTF1:
    Teratoma     Embryonal carcinoma

    Export disorders for UTF1 gene to outside databases

    Publications
    for UTF1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UTF1 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with UTF1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity. (PubMed id 9748258)1, 2, 3 Fukushima A....Muramatsu M. (1998)
    2. Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. (PubMed id 18281244)1, 3 Kristensen D.M....Leffers H. (2008)
    3. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    4. Regulation of pluripotency and self- renewal of ESCs t hrough epigenetic-threshold modulation and mRNA pruning. (PubMed id 23101626)1 Jia J....Zheng Y. (2012)
    5. Aberrant promoter methylation and expression of UTF1 d uring cervical carcinogenesis. (PubMed id 22880087)1 Guenin S....Delvenne P. (2012)
    6. Embryonic stem cell factors undifferentiated transcri ption factor-1 (UFT-1) and reduced expression protein-1 (REX-1) are widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination. (PubMed id 21446939)1 Reinisch C.M....Pammer J. (2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. Expression of UTF1 in primary and metastatic testicul ar germ cell tumors. (PubMed id 20855642)1 Wang P....Cao D. (2010)
    9. Functional characterization of single-nucleotide poly morphisms in the human undifferentiated embryonic-cell transcription factor 1 g ene. (PubMed id 20218897)1 Thummer R.P....Eggen B.J. (2010)
    10. Characterization of human UTF1, a chromatin-associate d protein with repressor activity expressed in pluripotent cells. (PubMed id 19393592)1 Kooistra S.M....Eggen B.J. (2009)

    External Searches for UTF1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UTF1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8433 HGNC: 12634 AceView: UTF1 Ensembl:ENSG00000171794 euGenes: HUgn8433
    ECgene: UTF1 H-InvDB: UTF1

    Other Databases showing UTF1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UTF1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UTF1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UTF1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UTF1 gene:
    Search GeneIP for patents involving UTF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for UTF1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of UTF1
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     Browse OriGene Antibodies   OriGene shRNA RFP for UTF1  
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UTF1
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     GenScript Custom Purified and Recombinant Proteins Services for UTF1 GenScript cDNA clones with any tag delivered in your preferred vector for UTF1
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     Antibodies & Assays for UTF1 

     Regulatory tfbs in UTF1 promoter
     Search Chromatin IP Primers for UTF1
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     Rabbit Monoclonal Antibody Platform
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     See all of Abcam's Antibodies, Kits and Proteins for UTF1
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     Browse ProSpec Recombinant Proteins




     UTF1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for UTF1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for UTF1
     SwitchGear 3'UTR luciferase reporter plasmids for UTF1
     SwitchGear Promoter luciferase reporter plasmids for UTF1
     ThermoFisher Antibodies for UTF1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTF1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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