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Aliases for UTF1 Gene

Aliases for UTF1 Gene

  • Undifferentiated Embryonic Cell Transcription Factor 1 2 3 5

External Ids for UTF1 Gene

Previous GeneCards Identifiers for UTF1 Gene

  • GC10P133958
  • GC10P134173
  • GC10P134959
  • GC10P134517
  • GC10P134932
  • GC10P135043
  • GC10P128590

Summaries for UTF1 Gene

Entrez Gene Summary for UTF1 Gene

  • The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this protein can also serve as a transcriptional repressor. [provided by RefSeq, Nov 2015]

GeneCards Summary for UTF1 Gene

UTF1 (Undifferentiated Embryonic Cell Transcription Factor 1) is a Protein Coding gene. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Wnt / Hedgehog / Notch. GO annotations related to this gene include transcription coactivator activity and HMG box domain binding.

UniProtKB/Swiss-Prot for UTF1 Gene

  • Acts as a transcriptional coactivator of ATF2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTF1 Gene

Genomics for UTF1 Gene

Regulatory Elements for UTF1 Gene

Enhancers for UTF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UTF1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the UTF1 gene promoter:

Genomic Location for UTF1 Gene

Chromosome:
10
Start:
133,230,274 bp from pter
End:
133,231,558 bp from pter
Size:
1,285 bases
Orientation:
Plus strand

Genomic View for UTF1 Gene

Genes around UTF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTF1 Gene

Proteins for UTF1 Gene

  • Protein details for UTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T230-UTF1_HUMAN
    Recommended name:
    Undifferentiated embryonic cell transcription factor 1
    Protein Accession:
    Q5T230
    Secondary Accessions:
    • O75833
    • Q6J1H3

    Protein attributes for UTF1 Gene

    Size:
    341 amino acids
    Molecular mass:
    36439 Da
    Quaternary structure:
    • Binds to the N-terminal region of ATF2. Associates with the TFIID complex through interaction with TBP.
    SequenceCaution:
    • Sequence=AAT38949.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for UTF1 Gene

Proteomics data for UTF1 Gene at MOPED

Post-translational modifications for UTF1 Gene

Other Protein References for UTF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UTF1 (UTF1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for UTF1

No data available for DME Specific Peptides for UTF1 Gene

Domains & Families for UTF1 Gene

Protein Domains for UTF1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for UTF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T230

UniProtKB/Swiss-Prot:

UTF1_HUMAN :
  • The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters (By similarity).
Domain:
  • The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters (By similarity).
genes like me logo Genes that share domains with UTF1: view

No data available for Gene Families for UTF1 Gene

Function for UTF1 Gene

Molecular function for UTF1 Gene

GENATLAS Biochemistry:
undifferentiated embryonic cell transcription factor 1 from the mouse F9 teratocarcinoma cell line,homolog,potentiating ATF-2 (activating transcription factor)-2 activity
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional coactivator of ATF2.
genes like me logo Genes that share phenotypes with UTF1: view

Animal Models for UTF1 Gene

MGI Knock Outs for UTF1:

Animal Model Products

miRNA for UTF1 Gene

miRTarBase miRNAs that target UTF1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UTF1 Gene

Localization for UTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UTF1 Gene COMPARTMENTS Subcellular localization image for UTF1 gene
Compartment Confidence
nucleus 5
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for UTF1 Gene

Pathways & Interactions for UTF1 Gene

genes like me logo Genes that share pathways with UTF1: view

Pathways by source for UTF1 Gene

Gene Ontology (GO) - Biological Process for UTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA,IDA 9748258
genes like me logo Genes that share ontologies with UTF1: view

No data available for SIGNOR curated interactions for UTF1 Gene

Drugs & Compounds for UTF1 Gene

No Compound Related Data Available

Transcripts for UTF1 Gene

mRNA/cDNA for UTF1 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for UTF1 Gene

No ASD Table

Relevant External Links for UTF1 Gene

GeneLoc Exon Structure for
UTF1
ECgene alternative splicing isoforms for
UTF1

Expression for UTF1 Gene

mRNA expression in normal human tissues for UTF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UTF1 Gene

This gene is overexpressed in Testis (x38.2).

Protein differential expression in normal tissues from HIPED for UTF1 Gene

This gene is overexpressed in Testis (33.0), Adipocyte (21.8), and Fetal ovary (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UTF1 Gene



SOURCE GeneReport for Unigene cluster for UTF1 Gene Hs.458406

genes like me logo Genes that share expression patterns with UTF1: view

Protein tissue co-expression partners for UTF1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for UTF1 Gene

Orthologs for UTF1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for UTF1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Utf1 35
  • 69.45 (n)
  • 64.31 (a)
Utf1 16
Utf1 36
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UTF1 35
  • 95.17 (n)
  • 92.41 (a)
rat
(Rattus norvegicus)
Mammalia Utf1 35
  • 70.63 (n)
  • 65.59 (a)
cow
(Bos Taurus)
Mammalia UTF1 36
  • 68 (a)
OneToOne
Species with no ortholog for UTF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UTF1 Gene

ENSEMBL:
Gene Tree for UTF1 (if available)
TreeFam:
Gene Tree for UTF1 (if available)

Paralogs for UTF1 Gene

No data available for Paralogs for UTF1 Gene

Variants for UTF1 Gene

Sequence variations from dbSNP and Humsavar for UTF1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11599284 - 133,230,505(+) TGCTG(A/G)GGACG reference, missense
rs2998111 -- 133,231,518(-) GAACG(A/G)GGGTG utr-variant-3-prime
rs2998112 -- 133,228,454(-) cccat(C/G)tctgc upstream-variant-2KB
rs3008362 -- 133,231,531(-) TGAAC(A/G)TACCC utr-variant-3-prime
rs4313492 -- 133,229,125(+) GGGTT(A/T)TGACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UTF1 Gene

Variant ID Type Subtype PubMed ID
nsv896182 CNV Loss 21882294
dgv856n71 CNV Loss 21882294
nsv528260 CNV Loss 19592680
dgv327e1 CNV Complex 17122850
dgv328e1 CNV Complex 17122850
nsv896258 CNV Loss 21882294
nsv832036 CNV Loss 17160897
nsv832038 CNV Gain+Loss 17160897
dgv878n71 CNV Loss 21882294
nsv896267 CNV Loss 21882294
dgv879n71 CNV Loss 21882294
dgv880n71 CNV Loss 21882294
nsv832039 CNV Loss 17160897
dgv881n71 CNV Loss 21882294
nsv470980 CNV Loss 18288195
dgv2e196 CNV Duplication 17116639
dgv882n71 CNV Loss 21882294
essv9566 CNV CNV 17122850
nsv8750 CNV Gain+Loss 18304495
dgv883n71 CNV Loss 21882294
dgv884n71 CNV Loss 21882294
dgv885n71 CNV Loss 21882294
dgv185n67 CNV Gain 20364138
nsv820950 CNV Deletion 20802225

Variation tolerance for UTF1 Gene

Gene Damage Index Score: 5.02; 68.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTF1 Gene

Human Gene Mutation Database (HGMD)
UTF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTF1 Gene

Disorders for UTF1 Gene

Relevant External Links for UTF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTF1

No disorders were found for UTF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTF1 Gene

Publications for UTF1 Gene

  1. Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity. (PMID: 9748258) Fukushima A. … Muramatsu M. (J. Biol. Chem. 1998) 2 3 4 67
  2. Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. (PMID: 18281244) Kristensen D.M. … Leffers H. (Hum. Reprod. 2008) 2 3
  3. The embryonic stem cell factor UTF1 serves as a reliable diagnostic marker for germinomas. (PMID: 24614704) Pantazis G. … Schittenhelm J. (Pathology 2014) 3
  4. Expression profile of undifferentiated cell transcription factor 1 in normal and cancerous human epithelia. (PMID: 24738751) Mouallif M. … Guenin S. (Int J Exp Pathol 2014) 3
  5. Use of UTF1 genetic control elements as iPSC reporter. (PMID: 22205530) Morshedi A. … DrAPge P. (Stem Cell Rev 2013) 3

Products for UTF1 Gene

Sources for UTF1 Gene

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