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UTF1 Gene

protein-coding   GIFtS: 50
GCID: GC10P135043

Undifferentiated Embryonic Cell Transcription Factor 1

  See UTF1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Undifferentiated Embryonic Cell Transcription Factor 11 2

External Ids:    HGNC: 126341   Entrez Gene: 84332   Ensembl: ENSG000001717947   OMIM: 6041305   UniProtKB: Q5T2303   

Export aliases for UTF1 gene to outside databases

Previous GC identifers: GC10P133958 GC10P134173 GC10P134959 GC10P134517 GC10P134932 GC10P128590


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UTF1 Gene:
UTF1 (undifferentiated embryonic cell transcription factor 1) is a protein-coding gene. Diseases associated with UTF1 include testicular germ cell tumor, and germ cell tumors. GO annotations related to this gene include transcription coactivator activity and HMG box domain binding.

UniProtKB/Swiss-Prot: UTF1_HUMAN, Q5T230
Function: Acts as a transcriptional coactivator of ATF2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the UTF1 gene promoter:
         AhR   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUTF1 promoter sequence
   Search Chromatin IP Primers for UTF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UTF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26

UTF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UTF1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P135043:  view genomic region     (about GC identifiers)

Start:
135,043,778 bp from pter      End:
135,045,062 bp from pter
Size:
1,285 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UTF1_HUMAN, Q5T230 (See protein sequence)
Recommended Name: Undifferentiated embryonic cell transcription factor 1  
Size: 341 amino acids; 36439 Da
Subunit: Binds to the N-terminal region of ATF2. Associates with the TFIID complex through interaction with TBP
Sequence caution: Sequence=AAT38949.1; Type=Erroneous initiation;
Secondary accessions: O75833 Q6J1H3

Explore the universe of human proteins at neXtProt for UTF1: NX_Q5T230

Explore proteomics data for UTF1 at MOPED

Post-translational modifications: 

  • Phosphorylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See UTF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003568.2  
    ENSEMBL proteins: 
     ENSP00000305906  

    UTF1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for UTF1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for UTF1
    GenScript Custom Purified and Recombinant Proteins Services for UTF1
    Novus Biologicals UTF1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UTF1

     
    Search eBioscience for Proteins for UTF1 

    UTF1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of UTF1
    R&D Systems Antibodies for UTF1
    Cell Signaling Technology (CST) Antibodies for UTF1 
    OriGene Antibodies for UTF1
    OriGene Custom Antibody Services for UTF1
    Novus Biologicals UTF1 Antibody
    Search for Antibodies for UTF1 at Abcam
    Cloud-Clone Corp. Antibodies for UTF1
    ThermoFisher Antibody for UTF1
    LSBio Antibodies in human, mouse, rat for UTF1

    UTF1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UTF1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UTF1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UTF1
    Cloud-Clone Corp. CLIAs for UTF1
    Search eBioscience for ELISAs for UTF1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q5T230

    UniProtKB/Swiss-Prot: UTF1_HUMAN, Q5T230
    Domain: The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein
    is able to stimulate transcription from a number of gene promoters (By similarity)


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UTF1_HUMAN, Q5T230
    Function: Acts as a transcriptional coactivator of ATF2

         Genatlas biochemistry entry for UTF1:
    undifferentiated embryonic cell transcription factor 1 from the mouse F9 teratocarcinoma cell
    line,homolog,potentiating ATF-2 (activating transcription factor)-2 activity

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA9748258
    GO:0005515protein binding IPI9748258
    GO:0071837HMG box domain binding IEA--
         
    Find genes that share ontologies with UTF1           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Utf1):
     cardiovascular system  cellular  embryogenesis  growth/size/body  mortality/aging 
     reproductive system  skeleton 

    Find genes that share phenotypes with UTF1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Utf1tm1Okud for UTF1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UTF1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UTF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UTF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UTF1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat UTF1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate UTF1
    SwitchGear 3'UTR luciferase reporter plasmidUTF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UTF1
    Predesigned siRNA for gene silencing in human, mouse, rat UTF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UTF1

    Clone
    Products:
         
    OriGene clones in human, mouse for UTF1 (see all 5)
    OriGene ORF clones in mouse, rat for UTF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UTF1 (NM_003577)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UTF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTF1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UTF1
    Browse ESI BIO Cell Lines and PureStem Progenitors for UTF1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UTF1_HUMAN, Q5T230: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18281244

    Find genes that share ontologies with UTF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UTF1 About    
    See pathways by source

    SuperPathContained pathways About
    1Human Embryonic Stem Cell Pluripotency
    Human Embryonic Stem Cell Pluripotency0.50
    2Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    3Selected targets of Oct 3 4
    Selected targets of Oct 3 4
    4Oct4 in Mammalian ESC Pluripotency
    Oct4 in Mammalian ESC Pluripotency


    Find genes that share SuperPaths with UTF1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UTF1
        Oct4 in Mammalian ESC Pluripotency
    Human Embryonic Stem Cell Pluripotency

    1 Cell Signaling Technology (CST) Pathway for UTF1
        Wnt / Hedgehog / Notch


        Pathway & Disease-focused RT2 Profiler PCR Array including UTF1: 
              Embryonic Stem Cells in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for UTF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for UTF1 (Q5T2303 ENSP000003059064) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF2P153363, ENSP000002641104I2D: score=3 STRING: ENSP00000264110
    SOX10P566933, ENSP000003541304I2D: score=2 STRING: ENSP00000354130
    SOX8P570733, ENSP000002938944I2D: score=1 STRING: ENSP00000293894
    AIFM1ENSP000002872954STRING: ENSP00000287295
    BCS1LENSP000003522194STRING: ENSP00000352219
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9748258
    GO:0008584male gonad development IEP18281244
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA9748258

    Find genes that share ontologies with UTF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UTF1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UTF1 gene: 
    NM_003577.2  

    Unigene Cluster for UTF1:

    Undifferentiated embryonic cell transcription factor 1
    Hs.458406
    Unigene Representative Sequence: AB011076
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304477(uc001lmc.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UTF1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate UTF1
    SwitchGear 3'UTR luciferase reporter plasmidUTF1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UTF1
    Predesigned siRNA for gene silencing in human, mouse, rat UTF1
    Clone
    Products:
         
    OriGene clones in human, mouse for UTF1 (see all 5)
    OriGene ORF clones in mouse, rat for UTF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UTF1 (NM_003577)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UTF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTF1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UTF1
    OriGene qSTAR qPCR primer pairs in human, mouse for UTF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UTF1
      Search QuantiTect SYBR Green Assays in human, mouse, rat UTF1
      QuantiFast Probe-based Assays in human, mouse, rat UTF1

    Additional mRNA sequence: 

    AB011076.2 AY606112.1 

    1 DOTS entry:

    DT.91745164 

    3 AceView cDNA sequences:

    AY606112 AB011076 NM_003577 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UTF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTGCTGG
    UTF1 Expression
    About this image


    UTF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 10 entries
             ESI-017
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Gonad
             XY Germ Cells Testis Cord
    UTF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UTF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458406
        Pathway & Disease-focused RT2 Profiler PCR Array including UTF1: 
              Embryonic Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UTF1
    OriGene qSTAR qPCR primer pairs in human, mouse for UTF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UTF1
    Search QuantiTect SYBR Green Assays in human, mouse, rat UTF1
    QuantiFast Probe-based Assays in human, mouse, rat UTF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for UTF1 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Utf11 , 5 undifferentiated embryonic cell transcription factor more1, 5 69.45(n)1
    64.31(a)1
      7 (84.91 cM)5
    222861  NM_009482.21  NP_033508.11 
     1399437895 


    ENSEMBL Gene Tree for UTF1 (if available)
    TreeFam Gene Tree for UTF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UTF1 (see all 69)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs29981121,2
    C,F,A--135041958(-) cccatG/Ctctgc 1 -- us2k111Minor allele frequency- C:0.44NA WA CSA EA 373
    rs1382368511,2
    --135042070(+) TATGAC/GTGCCT 1 -- us2k10--------
    rs1822655421,2
    --135042207(+) CAAGGA/GAGAGA 1 -- us2k10--------
    rs1872767971,2
    --135042209(+) AGGAAA/GAGAGG 1 -- us2k10--------
    rs124155901,2
    C,F,H--135042214(+) gagagG/Aaggag 1 -- us2k1 trp317Minor allele frequency- A:0.04NS EA NA 1704
    rs1907842811,2
    --135042236(+) TTCAAC/TGGCCA 1 -- us2k10--------
    rs1428418871,2
    C--135042281(+) AGCCCA/GGCACA 1 -- us2k10--------
    rs1171501601,2
    C,F--135042361(+) AAGACG/AAGCCT 1 -- us2k11Minor allele frequency- A:0.06NA 120
    rs1807927701,2
    --135042436(+) TGGTGA/GTGCAC 1 -- us2k10--------
    rs44697981,2
    C,F--135042528(+) caggcC/Tactgc 1 -- us2k12Minor allele frequency- T:0.03CSA WA 120

    HapMap Linkage Disequilibrium report for UTF1 (135043778 - 135045062 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UTF1 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820950CNV Deletion20802225
    dgv2e196CNV Duplication17116639
    nsv832036CNV Loss17160897
    nsv896267CNV Loss21882294
    dgv879n71CNV Loss21882294
    nsv832039CNV Loss17160897
    dgv884n71CNV Loss21882294
    nsv896258CNV Loss21882294
    dgv882n71CNV Loss21882294
    dgv880n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): UTF1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UTF1
    DNA2.0 Custom Variant and Variant Library Synthesis for UTF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604130    OMIM disorders: --

    2 diseases for UTF1:    
    About MalaCards
    testicular germ cell tumor    germ cell tumors

    2 diseases from the University of Copenhagen DISEASES database for UTF1:
    Teratoma     Embryonal carcinoma

    Find genes that share disorders with UTF1           About GenesLikeMe


    Export disorders for UTF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UTF1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with UTF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity. (PubMed id 9748258)1, 2, 3 Fukushima A....Muramatsu M. (J. Biol. Chem. 1998)
    2. Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. (PubMed id 18281244)1, 3 Kristensen D.M....Leffers H. (Hum. Reprod. 2008)
    3. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    4. Undifferentiated embryonic cell transcription factor-1 (UTF1) inhibits the growth of cervical cancer cells by transactivating p27Kip1. (PubMed id 23536577)1 Wu X.L. and Zheng P.S. (Carcinogenesis 2013)
    5. Regulation of pluripotency and self- renewal of ESCs through epigenetic-threshold modulation and mRNA pruning. (PubMed id 23101626)1 Jia J....Zheng Y. (Cell 2012)
    6. Aberrant promoter methylation and expression of UTF1 during cervical carcinogenesis. (PubMed id 22880087)1 Guenin S....Delvenne P. (PLoS ONE 2012)
    7. Embryonic stem cell factors undifferentiated transcription factor-1 (UFT-1) and reduced expression protein-1 (REX-1) are widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination. (PubMed id 21446939)1 Reinisch C.M....Pammer J. (Int J Exp Pathol 2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    9. Expression of UTF1 in primary and metastatic testicular germ cell tumors. (PubMed id 20855642)1 Wang P....Cao D. (Am. J. Clin. Pathol. 2010)
    10. Functional characterization of single-nucleotide polymorphisms in the human undifferentiated embryonic-cell transcription factor 1 gene. (PubMed id 20218897)1 Thummer R.P....Eggen B.J. (DNA Cell Biol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8433 HGNC: 12634 AceView: UTF1 Ensembl:ENSG00000171794 euGenes: HUgn8433
    ECgene: UTF1 H-InvDB: UTF1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UTF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UTF1 gene:
    Search GeneIP for patents involving UTF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of UTF1
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     OriGene Antibodies for UTF1   OriGene RNAi products in human, mouse, rat for UTF1  
     OriGene qPCR primer pairs and template standards for UTF1   OriGene Protein Over-expression Lysate for UTF1  
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     OriGene qSTAR qPCR primer pairs in human, mouse for UTF1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for UTF1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UTF1   OriGene Custom Protein Services for UTF1  

     
     
     Block miRNA regulation of human, mouse, rat UTF1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UTF1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UTF1 Predesigned siRNA for gene silencing in human, mouse, rat UTF1
     QuantiFast Probe-based Assays in human, mouse, rat UTF1 Search QuantiTect SYBR Green Assays in human, mouse, rat UTF1
     PCR Arrays including human, mouse, rat UTF1 Search Chromatin IP Primers for UTF1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UTF1  Search GeneGlobe Interaction Network for UTF1
     Regulatory tfbs in UTF1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for UTF1 GenScript cDNA clones with any tag delivered in your preferred vector for UTF1
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     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
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     Antibodies & Assays for UTF1 

     Search Tocris compounds for UTF1
     Browse Sino Biological Proteins
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     Search Sino Biological for antibodies, proteins & pathways
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Search for Antibodies for UTF1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for UTF1
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     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for UTF1
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     Browse ESI BIO Cell Lines and PureStem Progenitors for UTF1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UTF1
     SwitchGear 3'UTR luciferase reporter plasmids for UTF1
     SwitchGear Promoter luciferase reporter plasmids for UTF1
     ThermoFisher Antibody for UTF1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UTF1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UTF1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UTF1
     LSBio Antibodies in human, mouse, rat for UTF1
    Customized transgenic rodents for:
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     Tissue-specific gene expresssion
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     Browse compounds at ApexBio
     Search Addgene for plasmids for UTF1
      Search eBioscience for proteins for UTF1
      Search eBioscience for elisas for UTF1
      eBioscience FlowRNA Probe Sets
           
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