Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UTF1 Gene

Aliases for UTF1 Gene

  • Undifferentiated Embryonic Cell Transcription Factor 1 2 3 5

External Ids for UTF1 Gene

Previous GeneCards Identifiers for UTF1 Gene

  • GC10P133958
  • GC10P134173
  • GC10P134959
  • GC10P134517
  • GC10P134932
  • GC10P135043
  • GC10P128590

Summaries for UTF1 Gene

Entrez Gene Summary for UTF1 Gene

  • The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this protein can also serve as a transcriptional repressor. [provided by RefSeq, Nov 2015]

GeneCards Summary for UTF1 Gene

UTF1 (Undifferentiated Embryonic Cell Transcription Factor 1) is a Protein Coding gene. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Oct4 in Mammalian ESC Pluripotency. GO annotations related to this gene include transcription coactivator activity and HMG box domain binding.

UniProtKB/Swiss-Prot for UTF1 Gene

  • Acts as a transcriptional coactivator of ATF2.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UTF1 Gene

Genomics for UTF1 Gene

Regulatory Elements for UTF1 Gene

Enhancers for UTF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G133224 0.8 ENCODE 0.7 -5.0 -4980 0.9 PKNOX1 IRF2 TAL1 RBBP5 ZFHX2 GLIS2 FOXK2 POLR2A EGR1 KDM5B KNDC1 UTF1 LOC105378573
GH10G133234 1.3 FANTOM5 Ensembl ENCODE 0.4 +6.6 6552 4.1 RING1 RNF2 SUZ12 CBX2 MAX ZBTB7A HDAC2 EGR1 CTBP2 CREB1 TUBGCP2 ADAM8 VENTX UTF1
GH10G133230 0.7 ENCODE 0.7 +0.3 338 0.1 MXI1 L3MBTL2 SUZ12 NRF1 RBBP5 ZNF592 ZFHX2 NFIC NONO ZBTB26 UTF1 VENTX
GH10G133231 0.5 ENCODE 0.7 +2.0 1958 0.8 GLIS2 SUZ12 POU5F1 EZH2 KNDC1 UTF1 VENTX
GH10G133219 0.2 ENCODE 0.4 -10.2 -10233 0.2 LOC105378573 UTF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UTF1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the UTF1 gene promoter:

Genomic Location for UTF1 Gene

Chromosome:
10
Start:
133,230,274 bp from pter
End:
133,231,558 bp from pter
Size:
1,285 bases
Orientation:
Plus strand

Genomic View for UTF1 Gene

Genes around UTF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UTF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UTF1 Gene

Proteins for UTF1 Gene

  • Protein details for UTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T230-UTF1_HUMAN
    Recommended name:
    Undifferentiated embryonic cell transcription factor 1
    Protein Accession:
    Q5T230
    Secondary Accessions:
    • O75833
    • Q6J1H3

    Protein attributes for UTF1 Gene

    Size:
    341 amino acids
    Molecular mass:
    36439 Da
    Quaternary structure:
    • Binds to the N-terminal region of ATF2. Associates with the TFIID complex through interaction with TBP.
    SequenceCaution:
    • Sequence=AAT38949.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for UTF1 Gene

Post-translational modifications for UTF1 Gene

Other Protein References for UTF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UTF1 Gene

Domains & Families for UTF1 Gene

Protein Domains for UTF1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for UTF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T230

UniProtKB/Swiss-Prot:

UTF1_HUMAN :
  • The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters (By similarity).
Domain:
  • The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters (By similarity).
genes like me logo Genes that share domains with UTF1: view

No data available for Gene Families for UTF1 Gene

Function for UTF1 Gene

Molecular function for UTF1 Gene

GENATLAS Biochemistry:
undifferentiated embryonic cell transcription factor 1 from the mouse F9 teratocarcinoma cell line,homolog,potentiating ATF-2 (activating transcription factor)-2 activity
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional coactivator of ATF2.

Gene Ontology (GO) - Molecular Function for UTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 9748258
GO:0005515 protein binding IPI 9748258
GO:0071837 HMG box domain binding IEA --
genes like me logo Genes that share ontologies with UTF1: view
genes like me logo Genes that share phenotypes with UTF1: view

Animal Models for UTF1 Gene

MGI Knock Outs for UTF1:

Animal Model Products

CRISPR Products

miRNA for UTF1 Gene

miRTarBase miRNAs that target UTF1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UTF1 Gene

Localization for UTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UTF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UTF1 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for UTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 18281244
genes like me logo Genes that share ontologies with UTF1: view

Pathways & Interactions for UTF1 Gene

genes like me logo Genes that share pathways with UTF1: view

Pathways by source for UTF1 Gene

Gene Ontology (GO) - Biological Process for UTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9748258
GO:0008584 male gonad development IEP 18281244
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 9748258
genes like me logo Genes that share ontologies with UTF1: view

No data available for SIGNOR curated interactions for UTF1 Gene

Drugs & Compounds for UTF1 Gene

No Compound Related Data Available

Transcripts for UTF1 Gene

mRNA/cDNA for UTF1 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UTF1 Gene

No ASD Table

Relevant External Links for UTF1 Gene

GeneLoc Exon Structure for
UTF1
ECgene alternative splicing isoforms for
UTF1

Expression for UTF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UTF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UTF1 Gene

This gene is overexpressed in Testis (x38.2).

Protein differential expression in normal tissues from HIPED for UTF1 Gene

This gene is overexpressed in Testis (33.0), Adipocyte (21.8), and Fetal ovary (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UTF1 Gene



Protein tissue co-expression partners for UTF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of UTF1 Gene:

UTF1

SOURCE GeneReport for Unigene cluster for UTF1 Gene:

Hs.458406
genes like me logo Genes that share expression patterns with UTF1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UTF1 Gene

Orthologs for UTF1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for UTF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UTF1 34
  • 95.17 (n)
rat
(Rattus norvegicus)
Mammalia Utf1 34
  • 70.63 (n)
mouse
(Mus musculus)
Mammalia Utf1 34 16 35
  • 69.45 (n)
cow
(Bos Taurus)
Mammalia UTF1 35
  • 68 (a)
OneToOne
Species where no ortholog for UTF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UTF1 Gene

ENSEMBL:
Gene Tree for UTF1 (if available)
TreeFam:
Gene Tree for UTF1 (if available)

Paralogs for UTF1 Gene

No data available for Paralogs for UTF1 Gene

Variants for UTF1 Gene

Sequence variations from dbSNP and Humsavar for UTF1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000832452 -- 133,229,421(+) GGAGG(A/G)GCGAG upstream-variant-2KB
rs1002005357 -- 133,229,056(+) AGAGA(C/G)CCCAT upstream-variant-2KB
rs1002458680 -- 133,230,371(+) GCGGA(C/T)ACCCG reference, missense
rs1002622890 -- 133,230,678(+) CACGG(C/T)CAGCC reference, synonymous-codon
rs1004016861 -- 133,231,949(+) CCTCC(A/G)CACTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for UTF1 Gene

Variant ID Type Subtype PubMed ID
dgv1474n54 CNV loss 21841781
dgv185n67 CNV gain 20364138
dgv2e196 CNV duplication 17116639
dgv558n106 CNV deletion 24896259
esv2759793 CNV gain+loss 17122850
esv2760107 CNV gain 21179565
esv3625030 CNV gain 21293372
esv3625031 CNV gain 21293372
nsv1159784 CNV deletion 26073780
nsv1159785 CNV deletion 26073780
nsv470980 CNV loss 18288195
nsv528260 CNV loss 19592680
nsv552574 CNV gain 21841781
nsv820950 CNV deletion 20802225
nsv832036 CNV loss 17160897
nsv832038 CNV gain+loss 17160897
nsv832039 CNV loss 17160897
nsv8750 CNV gain+loss 18304495
nsv952705 CNV deletion 24416366

Variation tolerance for UTF1 Gene

Gene Damage Index Score: 5.02; 68.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UTF1 Gene

Human Gene Mutation Database (HGMD)
UTF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UTF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UTF1 Gene

Disorders for UTF1 Gene

Relevant External Links for UTF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UTF1

No disorders were found for UTF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UTF1 Gene

Publications for UTF1 Gene

  1. Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity. (PMID: 9748258) Fukushima A. … Muramatsu M. (J. Biol. Chem. 1998) 2 3 4 64
  2. Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. (PMID: 18281244) Kristensen D.M. … Leffers H. (Hum. Reprod. 2008) 2 3 64
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  4. Expression profile of undifferentiated cell transcription factor 1 in normal and cancerous human epithelia. (PMID: 24738751) Mouallif M. … Guenin S. (Int J Exp Pathol 2014) 3 64
  5. The embryonic stem cell factor UTF1 serves as a reliable diagnostic marker for germinomas. (PMID: 24614704) Pantazis G. … Schittenhelm J. (Pathology 2014) 3 64

Products for UTF1 Gene

Sources for UTF1 Gene

Content
Loading form....