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Aliases for UST Gene

Aliases for UST Gene

  • Uronyl-2-Sulfotransferase 2 3
  • Dermatan/Chondroitin Sulfate 2-Sulfotransferase 3
  • Uronyl 2-Sulfotransferase 3
  • EC 2.8.2.- 4
  • DS2ST 4
  • 2OST 3

External Ids for UST Gene

Summaries for UST Gene

Entrez Gene Summary for UST Gene

  • Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UST Gene

UST (Uronyl-2-Sulfotransferase) is a Protein Coding gene. Diseases associated with UST include liver inflammatory pseudotumor and female stress incontinence. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is ENSG00000267561.

UniProtKB/Swiss-Prot for UST Gene

  • Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UST Gene

Genomics for UST Gene

Genomic Location for UST Gene

Start:
148,746,928 bp from pter
End:
149,076,990 bp from pter
Size:
330,063 bases
Orientation:
Plus strand

Genomic View for UST Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UST Gene

Regulatory Elements for UST Gene

Proteins for UST Gene

  • Protein details for UST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2C2-UST_HUMAN
    Recommended name:
    Uronyl 2-sulfotransferase
    Protein Accession:
    Q9Y2C2
    Secondary Accessions:
    • B2RCX6

    Protein attributes for UST Gene

    Size:
    406 amino acids
    Molecular mass:
    47673 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UST Gene

Proteomics data for UST Gene at MOPED

Post-translational modifications for UST Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys32
  • Glycosylation at Asn84, Asn140, Asn155, Asn173, and Asn319

Other Protein References for UST Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for UST Gene

Domains for UST Gene

Gene Families for UST Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for UST Gene

UniProtKB/Swiss-Prot:

UST_HUMAN
Family:
  • Belongs to the sulfotransferase 3 family.:
    • Q9Y2C2
genes like me logo Genes that share domains with UST: view

Function for UST Gene

Molecular function for UST Gene

UniProtKB/Swiss-Prot Function: Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin

Enzyme Numbers (IUBMB) for UST Gene

Gene Ontology (GO) - Molecular Function for UST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001733 galactosylceramide sulfotransferase activity --
GO:0008146 sulfotransferase activity IEA --
genes like me logo Genes that share ontologies with UST: view

miRNA for UST Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for UST Gene

Localization for UST Gene

Subcellular locations from UniProtKB/Swiss-Prot for UST Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UST Gene COMPARTMENTS Subcellular localization image for UST gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for UST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UST: view

Pathways for UST Gene

genes like me logo Genes that share pathways with UST: view

Gene Ontology (GO) - Biological Process for UST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006477 protein sulfation TAS 10187838
GO:0009058 biosynthetic process --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030204 chondroitin sulfate metabolic process TAS --
genes like me logo Genes that share ontologies with UST: view

Compounds for UST Gene

(1) HMDB Compounds for UST Gene

Compound Synonyms Cas Number PubMed IDs
Dermatan
  • Chondroitin sulfate B
24967-94-0

(1) PharmGKB related drug/compound annotations for UST Gene

Drug/compound Annotation
nortriptyline CA
genes like me logo Genes that share compounds with UST: view

Transcripts for UST Gene

Unigene Clusters for UST Gene

Uronyl-2-sulfotransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UST Gene

No ASD Table

Relevant External Links for UST Gene

GeneLoc Exon Structure for
UST
ECgene alternative splicing isoforms for
UST

Expression for UST Gene

mRNA expression in normal human tissues for UST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UST Gene

SOURCE GeneReport for Unigene cluster for UST Gene Hs.657370

mRNA Expression by UniProt/SwissProt for UST Gene

Q9Y2C2-UST_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with UST: view

Orthologs for UST Gene

This gene was present in the common ancestor of animals.

Orthologs for UST Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UST 36
  • 97.07 (n)
  • 95.97 (a)
UST 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UST 36
  • 92.83 (n)
  • 97.5 (a)
dog
(Canis familiaris)
Mammalia UST 36
  • 94.07 (n)
  • 97.78 (a)
UST 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ust 36
  • 90.29 (n)
  • 96.3 (a)
Ust 16
Ust 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UST 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 79 (a)
OneToMany
-- 37
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ust 36
  • 90.12 (n)
  • 96.54 (a)
chicken
(Gallus gallus)
Aves UST 36
  • 84.62 (n)
  • 95.36 (a)
UST 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UST 37
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ust 36
  • 75.55 (n)
  • 84.89 (a)
zebrafish
(Danio rerio)
Actinopterygii ust 36
  • 70.2 (n)
  • 73.18 (a)
ust 37
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pip 37
  • 16 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToMany
-- 37
  • 35 (a)
OneToMany
Species with no ortholog for UST:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UST Gene

ENSEMBL:
Gene Tree for UST (if available)
TreeFam:
Gene Tree for UST (if available)

Paralogs for UST Gene

Paralogs for UST Gene

Selected SIMAP similar genes for UST Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UST: view

Variants for UST Gene

Sequence variations from dbSNP and Humsavar for UST Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs729094 -- 148,972,820(+) CTGAT(G/T)CCTGG intron-variant
rs729095 -- 148,972,881(+) tttgg(A/G)atttt intron-variant
rs729503 -- 148,973,440(-) TTGGC(C/T)TGCAT intron-variant
rs747944 -- 148,973,337(-) TTTAT(A/T)CATCA intron-variant
rs753423 -- 148,810,028(+) ATCTT(A/C)TCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UST Gene

Variant ID Type Subtype PubMed ID
esv269601 CNV Insertion 20981092
esv2732848 CNV Deletion 23290073
esv2732849 CNV Deletion 23290073
esv27051 CNV Loss 19812545
esv2732850 CNV Deletion 23290073
esv2732852 CNV Deletion 23290073
nsv464074 CNV Loss 19166990
nsv464075 CNV Loss 19166990
nsv470865 CNV Loss 18288195
esv2430067 CNV Deletion 19546169
esv259907 OTHER Complex 20981092
esv27730 CNV Loss 19812545
nsv830842 CNV Gain 17160897
esv2672117 CNV Deletion 23128226
esv2668797 CNV Deletion 23128226
esv2675997 CNV Deletion 23128226
esv2666090 CNV Deletion 23128226
esv992551 CNV Insertion 20482838
esv2067920 CNV Deletion 18987734
dgv1066n67 CNV Loss 20364138
esv2673783 CNV Deletion 23128226
esv2732853 CNV Deletion 23290073

Relevant External Links for UST Gene

HapMap Linkage Disequilibrium report
UST
Human Gene Mutation Database (HGMD)
UST

Disorders for UST Gene

(2) University of Copenhagen DISEASES for UST Gene

Relevant External Links for UST

Genetic Association Database (GAD)
UST
Human Genome Epidemiology (HuGE) Navigator
UST
genes like me logo Genes that share disorders with UST: view

No data available for UniProtKB/Swiss-Prot for UST Gene

Publications for UST Gene

  1. Molecular cloning and characterization of a human uronyl 2- sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate. (PMID: 10187838) Kobayashi M. … Rosenberg R.D. (J. Biol. Chem. 1999) 2 3 4 23
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 49
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. (PMID: 20360315) Uher R. … McGuffin P. (Am J Psychiatry 2010) 3 49

Products for UST Gene

Sources for UST Gene

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