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Aliases for UST Gene

Aliases for UST Gene

  • Uronyl 2-Sulfotransferase 2 3 5
  • Dermatan/Chondroitin Sulfate 2-Sulfotransferase 3
  • EC 2.8.2.- 4
  • DS2ST 4
  • 2OST 3

External Ids for UST Gene

Previous GeneCards Identifiers for UST Gene

  • GC06P148915
  • GC06P149049
  • GC06P149110
  • GC06P146637

Summaries for UST Gene

Entrez Gene Summary for UST Gene

  • Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UST Gene

UST (Uronyl 2-Sulfotransferase) is a Protein Coding gene. Diseases associated with UST include Liver Inflammatory Pseudotumor and Female Stress Incontinence. Among its related pathways are Metabolism and Chondroitin sulfate/dermatan sulfate metabolism. GO annotations related to this gene include sulfotransferase activity and galactosylceramide sulfotransferase activity. An important paralog of this gene is HS2ST1.

UniProtKB/Swiss-Prot for UST Gene

  • Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UST Gene

Genomics for UST Gene

Regulatory Elements for UST Gene

Enhancers for UST Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F148983 0.2 ENCODE 8.2 +237.1 237080 1.8 GLIS1 ZIC2 UST UST-AS1 LOC105378047
GH06F148979 0.2 ENCODE 7.7 +232.6 232628 1.2 ELF3 TBP ATF1 MLX ARID4B DMAP1 ZNF48 ZSCAN9 RAD21 RARA UST UST-AS1 LOC105378047
GH06F148598 0.7 ENCODE 7.7 -147.4 -147412 3.0 PKNOX1 ZNF792 RNF2 FOXA3 TEAD4 NFYC ZNF644 GATA3 CBX8 POU5F1 UST-AS1 UST SNRPEP6 GC06M148648
GH06F148972 1.3 Ensembl ENCODE 7 +225.6 225645 1.0 PKNOX1 KLF17 SIN3A FEZF1 ZNF2 ETS1 SCRT2 FOS SP5 JUNB PPIL4 RNU7-3P UST UST-AS1 LOC105378047
GH06F148967 1.5 FANTOM5 Ensembl ENCODE 6.8 +222.1 222102 3.8 ZMYM3 ZNF384 ZIC2 RARA ZNF316 SCRT2 FOS NFE2 MAFK NFE2L2 PPIL4 RNU7-3P UST UST-AS1 LOC105378047
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UST on UCSC Golden Path with GeneCards custom track

Promoters for UST Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001230271 638 3201 SIN3A FEZF1 ZNF2 ETS1 ZNF121 GLIS2 FOS SP3 ZNF610 SMARCA4

Genomic Location for UST Gene

Chromosome:
6
Start:
148,746,962 bp from pter
End:
149,076,990 bp from pter
Size:
330,029 bases
Orientation:
Plus strand

Genomic View for UST Gene

Genes around UST on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UST Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UST Gene

Proteins for UST Gene

  • Protein details for UST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2C2-UST_HUMAN
    Recommended name:
    Uronyl 2-sulfotransferase
    Protein Accession:
    Q9Y2C2
    Secondary Accessions:
    • B2RCX6

    Protein attributes for UST Gene

    Size:
    406 amino acids
    Molecular mass:
    47673 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UST Gene

Post-translational modifications for UST Gene

  • Ubiquitination at Lys 32
  • Glycosylation at Asn 84, Asn 140, Asn 155, Asn 173, and Asn 319
  • Modification sites at PhosphoSitePlus

Other Protein References for UST Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UST Gene

Domains & Families for UST Gene

Gene Families for UST Gene

Protein Domains for UST Gene

Suggested Antigen Peptide Sequences for UST Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2C2

UniProtKB/Swiss-Prot:

UST_HUMAN :
  • Belongs to the sulfotransferase 3 family.
Family:
  • Belongs to the sulfotransferase 3 family.
genes like me logo Genes that share domains with UST: view

Function for UST Gene

Molecular function for UST Gene

UniProtKB/Swiss-Prot Function:
Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin.

Enzyme Numbers (IUBMB) for UST Gene

Gene Ontology (GO) - Molecular Function for UST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity TAS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with UST: view
genes like me logo Genes that share phenotypes with UST: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UST Gene

Localization for UST Gene

Subcellular locations from UniProtKB/Swiss-Prot for UST Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UST Gene COMPARTMENTS Subcellular localization image for UST gene
Compartment Confidence
golgi apparatus 5
mitochondrion 3
plasma membrane 3
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for UST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS --
genes like me logo Genes that share ontologies with UST: view

Pathways & Interactions for UST Gene

genes like me logo Genes that share pathways with UST: view

Gene Ontology (GO) - Biological Process for UST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006477 protein sulfation TAS 10187838
GO:0030010 establishment of cell polarity IEA --
GO:0030208 dermatan sulfate biosynthetic process TAS --
GO:0050770 regulation of axonogenesis IEA --
genes like me logo Genes that share ontologies with UST: view

No data available for SIGNOR curated interactions for UST Gene

Drugs & Compounds for UST Gene

(1) Drugs for UST Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nortriptyline Approved Pharma Antagonist, Pore Blocker 50

(1) Additional Compounds for UST Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dermatan
  • b-Heparin
  • beta-Heparin
  • Chondroitin sulfate B
  • Chondroitin sulfate type B
  • Chondroitin sulphate B
24967-94-0
genes like me logo Genes that share compounds with UST: view

Transcripts for UST Gene

Unigene Clusters for UST Gene

Uronyl-2-sulfotransferase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UST Gene

No ASD Table

Relevant External Links for UST Gene

GeneLoc Exon Structure for
UST
ECgene alternative splicing isoforms for
UST

Expression for UST Gene

mRNA expression in normal human tissues for UST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UST Gene

This gene is overexpressed in Pancreas (60.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UST Gene



Protein tissue co-expression partners for UST Gene

NURSA nuclear receptor signaling pathways regulating expression of UST Gene:

UST

SOURCE GeneReport for Unigene cluster for UST Gene:

Hs.657370

mRNA Expression by UniProt/SwissProt for UST Gene:

Q9Y2C2-UST_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with UST: view

Primer Products

No data available for mRNA differential expression in normal tissues for UST Gene

Orthologs for UST Gene

This gene was present in the common ancestor of animals.

Orthologs for UST Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UST 34 35
  • 97.07 (n)
dog
(Canis familiaris)
Mammalia UST 34 35
  • 94.07 (n)
oppossum
(Monodelphis domestica)
Mammalia UST 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UST 34
  • 92.83 (n)
mouse
(Mus musculus)
Mammalia Ust 34 16 35
  • 90.29 (n)
rat
(Rattus norvegicus)
Mammalia Ust 34
  • 90.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 86 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves UST 34 35
  • 84.62 (n)
lizard
(Anolis carolinensis)
Reptilia UST 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ust 34
  • 75.55 (n)
zebrafish
(Danio rerio)
Actinopterygii ust 34 35
  • 70.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta pip 35
  • 16 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
-- 35
  • 32 (a)
OneToMany
Species where no ortholog for UST was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UST Gene

ENSEMBL:
Gene Tree for UST (if available)
TreeFam:
Gene Tree for UST (if available)

Paralogs for UST Gene

Paralogs for UST Gene

(1) SIMAP similar genes for UST Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UST: view

Variants for UST Gene

Sequence variations from dbSNP and Humsavar for UST Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10046358 -- 148,986,729(+) TCCTG(A/C)AACCA intron-variant
rs10080240 -- 149,002,945(+) ATCCA(A/G)TTATT intron-variant
rs10080254 -- 148,953,995(+) TCTAA(C/T)GAACA intron-variant, downstream-variant-500B
rs10080691 -- 148,895,239(+) ACATT(C/T)TCTCC intron-variant
rs1017851 -- 148,937,373(+) AATGA(C/T)ACAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UST Gene

Variant ID Type Subtype PubMed ID
dgv1066n67 CNV loss 20364138
dgv1838e212 CNV loss 25503493
esv2067920 CNV deletion 18987734
esv2430067 CNV deletion 19546169
esv2666090 CNV deletion 23128226
esv2668797 CNV deletion 23128226
esv2672117 CNV deletion 23128226
esv2673783 CNV deletion 23128226
esv2675997 CNV deletion 23128226
esv27051 CNV loss 19812545
esv2732848 CNV deletion 23290073
esv2732849 CNV deletion 23290073
esv2732850 CNV deletion 23290073
esv2732852 CNV deletion 23290073
esv2732853 CNV deletion 23290073
esv27730 CNV loss 19812545
esv3302933 CNV tandem duplication 20981092
esv3305323 CNV mobile element insertion 20981092
esv3326645 CNV insertion 20981092
esv3540613 CNV deletion 23714750
esv3611197 CNV loss 21293372
esv3611200 CNV loss 21293372
esv3611201 CNV loss 21293372
esv3611202 CNV loss 21293372
esv992551 CNV insertion 20482838
nsv1073594 CNV deletion 25765185
nsv1109820 CNV deletion 24896259
nsv464074 CNV loss 19166990
nsv464075 CNV loss 19166990
nsv470865 CNV loss 18288195
nsv604844 CNV loss 21841781
nsv604845 CNV loss 21841781
nsv830842 CNV gain 17160897
nsv949865 CNV deletion 24416366

Variation tolerance for UST Gene

Residual Variation Intolerance Score: 49.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UST Gene

Human Gene Mutation Database (HGMD)
UST
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UST

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UST Gene

Disorders for UST Gene

MalaCards: The human disease database

(6) MalaCards diseases for UST Gene - From: DISEASES

Disorder Aliases PubMed IDs
liver inflammatory pseudotumor
  • inflammatory pseudotumor of the liver
female stress incontinence
  • female urinary stress incontinence
listeria meningitis
  • meningitis, listeria
developmental coordination disorder
  • motor skills disorders
phobia, specific
  • specific phobia
- elite association - COSMIC cancer census association via MalaCards
Search UST in MalaCards View complete list of genes associated with diseases

Relevant External Links for UST

Genetic Association Database (GAD)
UST
Human Genome Epidemiology (HuGE) Navigator
UST
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UST
genes like me logo Genes that share disorders with UST: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UST Gene

Publications for UST Gene

  1. Molecular cloning and characterization of a human uronyl 2- sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate. (PMID: 10187838) Kobayashi M. … Rosenberg R.D. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. (PMID: 20360315) Uher R. … McGuffin P. (Am J Psychiatry 2010) 3 46 64
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for UST Gene

Sources for UST Gene

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