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Aliases for UST Gene

Aliases for UST Gene

  • Uronyl-2-Sulfotransferase 2 3
  • Dermatan/Chondroitin Sulfate 2-Sulfotransferase 3
  • EC 2.8.2.- 4
  • DS2ST 4
  • 2OST 3

External Ids for UST Gene

Previous GeneCards Identifiers for UST Gene

  • GC06P148915
  • GC06P149049
  • GC06P149110
  • GC06P146637

Summaries for UST Gene

Entrez Gene Summary for UST Gene

  • Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UST Gene

UST (Uronyl-2-Sulfotransferase) is a Protein Coding gene. Diseases associated with UST include liver inflammatory pseudotumor and female stress incontinence. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include sulfotransferase activity and galactosylceramide sulfotransferase activity. An important paralog of this gene is ENSG00000267561.

UniProtKB/Swiss-Prot for UST Gene

  • Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UST Gene

Genomics for UST Gene

Regulatory Elements for UST Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UST Gene

Chromosome:
6
Start:
148,746,962 bp from pter
End:
149,076,990 bp from pter
Size:
330,029 bases
Orientation:
Plus strand

Genomic View for UST Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UST Gene

Proteins for UST Gene

  • Protein details for UST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2C2-UST_HUMAN
    Recommended name:
    Uronyl 2-sulfotransferase
    Protein Accession:
    Q9Y2C2
    Secondary Accessions:
    • B2RCX6

    Protein attributes for UST Gene

    Size:
    406 amino acids
    Molecular mass:
    47673 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UST Gene

Proteomics data for UST Gene at MOPED

Post-translational modifications for UST Gene

  • Ubiquitination at Lys 32
  • Glycosylation at Asn 84, Asn 140, Asn 155, Asn 173, and Asn 319
  • Modification sites at PhosphoSitePlus

Other Protein References for UST Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UST Gene

Domains & Families for UST Gene

Gene Families for UST Gene

Protein Domains for UST Gene

Suggested Antigen Peptide Sequences for UST Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2C2

UniProtKB/Swiss-Prot:

UST_HUMAN :
  • Belongs to the sulfotransferase 3 family.
Family:
  • Belongs to the sulfotransferase 3 family.
genes like me logo Genes that share domains with UST: view

Function for UST Gene

Molecular function for UST Gene

UniProtKB/Swiss-Prot Function:
Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin

Enzyme Numbers (IUBMB) for UST Gene

Gene Ontology (GO) - Molecular Function for UST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity IEA --
genes like me logo Genes that share ontologies with UST: view

Phenotypes for UST Gene

GenomeRNAi human phenotypes for UST:
genes like me logo Genes that share phenotypes with UST: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UST

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for UST Gene

Localization for UST Gene

Subcellular locations from UniProtKB/Swiss-Prot for UST Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UST Gene COMPARTMENTS Subcellular localization image for UST gene
Compartment Confidence
golgi apparatus 4
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for UST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UST: view

Pathways & Interactions for UST Gene

genes like me logo Genes that share pathways with UST: view

Gene Ontology (GO) - Biological Process for UST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006477 protein sulfation TAS 10187838
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030204 chondroitin sulfate metabolic process TAS --
GO:0030208 dermatan sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with UST: view

No data available for SIGNOR curated interactions for UST Gene

Drugs & Compounds for UST Gene

(1) Drugs for UST Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nortriptyline Approved Pharma Antagonist, Pore Blocker 46

(1) Additional Compounds for UST Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dermatan
  • b-Heparin
  • beta-Heparin
  • Chondroitin sulfate B
  • Chondroitin sulfate type B
  • Chondroitin sulphate B
24967-94-0
genes like me logo Genes that share compounds with UST: view

Transcripts for UST Gene

Unigene Clusters for UST Gene

Uronyl-2-sulfotransferase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UST

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UST Gene

No ASD Table

Relevant External Links for UST Gene

GeneLoc Exon Structure for
UST
ECgene alternative splicing isoforms for
UST

Expression for UST Gene

mRNA expression in normal human tissues for UST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UST Gene

This gene is overexpressed in Pancreas (60.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UST Gene



SOURCE GeneReport for Unigene cluster for UST Gene Hs.657370

mRNA Expression by UniProt/SwissProt for UST Gene

Q9Y2C2-UST_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with UST: view

Protein tissue co-expression partners for UST Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UST Gene

Orthologs for UST Gene

This gene was present in the common ancestor of animals.

Orthologs for UST Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UST 35
  • 92.83 (n)
  • 97.5 (a)
dog
(Canis familiaris)
Mammalia UST 35
  • 94.07 (n)
  • 97.78 (a)
UST 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ust 35
  • 90.29 (n)
  • 96.3 (a)
Ust 16
Ust 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UST 35
  • 97.07 (n)
  • 95.97 (a)
UST 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ust 35
  • 90.12 (n)
  • 96.54 (a)
oppossum
(Monodelphis domestica)
Mammalia UST 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves UST 35
  • 84.62 (n)
  • 95.36 (a)
UST 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UST 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ust 35
  • 75.55 (n)
  • 84.89 (a)
zebrafish
(Danio rerio)
Actinopterygii ust 35
  • 70.2 (n)
  • 73.18 (a)
ust 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pip 36
  • 16 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
Species with no ortholog for UST:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UST Gene

ENSEMBL:
Gene Tree for UST (if available)
TreeFam:
Gene Tree for UST (if available)

Paralogs for UST Gene

Paralogs for UST Gene

(1) SIMAP similar genes for UST Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UST: view

Variants for UST Gene

Sequence variations from dbSNP and Humsavar for UST Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs729094 -- 148,972,820(+) CTGAT(G/T)CCTGG intron-variant
rs729095 -- 148,972,881(+) tttgg(A/G)atttt intron-variant
rs729503 -- 148,973,440(-) TTGGC(C/T)TGCAT intron-variant
rs747944 -- 148,973,337(-) TTTAT(A/T)CATCA intron-variant
rs753423 -- 148,810,028(+) ATCTT(A/C)TCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UST Gene

Variant ID Type Subtype PubMed ID
esv269601 CNV Insertion 20981092
esv2732848 CNV Deletion 23290073
esv2732849 CNV Deletion 23290073
esv27051 CNV Loss 19812545
esv2732850 CNV Deletion 23290073
esv2732852 CNV Deletion 23290073
nsv464074 CNV Loss 19166990
nsv464075 CNV Loss 19166990
nsv470865 CNV Loss 18288195
esv2430067 CNV Deletion 19546169
esv259907 OTHER Complex 20981092
esv27730 CNV Loss 19812545
nsv830842 CNV Gain 17160897
esv2672117 CNV Deletion 23128226
esv2668797 CNV Deletion 23128226
esv2675997 CNV Deletion 23128226
esv2666090 CNV Deletion 23128226
esv992551 CNV Insertion 20482838
esv2067920 CNV Deletion 18987734
dgv1066n67 CNV Loss 20364138
esv2673783 CNV Deletion 23128226
esv2732853 CNV Deletion 23290073

Variation tolerance for UST Gene

Residual Variation Intolerance Score: 49.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UST Gene

HapMap Linkage Disequilibrium report
UST
Human Gene Mutation Database (HGMD)
UST

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UST Gene

Disorders for UST Gene

MalaCards: The human disease database

(4) MalaCards diseases for UST Gene - From: DISEASES

Disorder Aliases PubMed IDs
liver inflammatory pseudotumor
  • inflammatory pseudotumor of the liver
female stress incontinence
  • stress incontinence, female
phobia, specific
  • specific phobia
corneal edema
  • corneal edema, unspecified
- elite association
Search UST in MalaCards View complete list of genes associated with diseases

Relevant External Links for UST

Genetic Association Database (GAD)
UST
Human Genome Epidemiology (HuGE) Navigator
UST
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UST
genes like me logo Genes that share disorders with UST: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UST Gene

Publications for UST Gene

  1. Molecular cloning and characterization of a human uronyl 2- sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate. (PMID: 10187838) Kobayashi M. … Rosenberg R.D. (J. Biol. Chem. 1999) 2 23 67
  2. Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene. (PMID: 25456346) Nievergelt C.M. … Baker D.G. (Psychoneuroendocrinology 2015) 67
  3. Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus. (PMID: 23620144) Sulkava S. … Paunio T. (Hum. Mol. Genet. 2013) 67
  4. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. (PMID: 20360315) Uher R. … McGuffin P. (Am J Psychiatry 2010) 67
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67

Products for UST Gene

Sources for UST Gene

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