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UST Gene

protein-coding   GIFtS: 60
GCID: GC06P149110

Uronyl-2-Sulfotransferase

  See UST-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
uronyl-2-sulfotransferase1 2
2OST2
Dermatan/Chondroitin Sulfate 2-Sulfotransferase2
Uronyl 2-Sulfotransferase2
DS2ST3
EC 2.8.2.-3

External Ids:    HGNC: 172231   Entrez Gene: 100902   Ensembl: ENSG000001119627   OMIM: 6107525   UniProtKB: Q9Y2C23   

Export aliases for UST gene to outside databases

Previous GC identifers: GC06P148721 GC06P148915 GC06P149049 GC06P146637


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UST Gene:
Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in
dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 (PubMed
10187838)).(supplied by OMIM, Mar 2008)

GeneCards Summary for UST Gene:
UST (uronyl-2-sulfotransferase) is a protein-coding gene. Diseases associated with UST include liver inflammatory pseudotumor, and female stress incontinence. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is HS2ST1.

UniProtKB/Swiss-Prot: UST_HUMAN, Q9Y2C2
Function: Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly
activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of
chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UST gene promoter:
         MEF-2A   IRF-2   ATF-2   aMEF-2   c-Jun   CUTL1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UST promoter sequence
   Search Chromatin IP Primers for UST

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.1   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q25.1

UST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UST gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P149110:  view genomic region     (about GC identifiers)

Start:
149,068,271 bp from pter      End:
149,398,126 bp from pter
Size:
329,856 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UST_HUMAN, Q9Y2C2 (See protein sequence)
Recommended Name: Uronyl 2-sulfotransferase  
Size: 406 amino acids; 47673 Da
Secondary accessions: B2RCX6

Explore the universe of human proteins at neXtProt for UST: NX_Q9Y2C2

Explore proteomics data for UST at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys32
  • Glycosylation2 at Asn84, Asn140, Asn155, Asn173, Asn319
  • Modification sites at PhosphoSitePlus

  • See UST Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005706.1  
    ENSEMBL proteins: 
     ENSP00000356433  
    Reactome Protein details: Q9Y2C2

    UST Human Recombinant Protein Products:

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    Novus Biologicals UST Lysate
    Browse Sino Biological Recombinant Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UST

     
    Search eBioscience for Proteins for UST 

    UST Antibody Products:

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    LSBio Antibodies in human, mouse, rat for UST

    UST Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UST
    Cloud-Clone Corp. CLIAs for UST
    Search eBioscience for ELISAs for UST 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    3 InterPro protein domains:
     IPR005331 Sulfotransferase
     IPR007734 Heparan_SO4_2-O-STrfase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9Y2C2

    ProtoNet protein and cluster: Q9Y2C2

    UniProtKB/Swiss-Prot: UST_HUMAN, Q9Y2C2
    Similarity: Belongs to the sulfotransferase 3 family


    Find genes that share domains with UST           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UST_HUMAN, Q9Y2C2
    Function: Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly
    activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of
    chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin

         Enzyme Number (IUBMB): EC 2.8.2.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001733galactosylceramide sulfotransferase activity ----
    GO:0008146sulfotransferase activity IEA--
         
    Find genes that share ontologies with UST           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UST
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UST

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UST
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UST

    miRNA
    Products:
        
    miRTarBase miRNAs that target UST:
    hsa-mir-98-5p (MIRT027844), hsa-mir-1 (MIRT002811), hsa-mir-1296-5p (MIRT036139), hsa-mir-335-5p (MIRT019065)

    Block miRNA regulation of human, mouse, rat UST using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UST (see all 65):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-21* hsa-miR-562 hsa-miR-4307 hsa-miR-379* hsa-miR-376b hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidUST 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UST
    Predesigned siRNA for gene silencing in human, mouse, rat UST

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UST

    Clone
    Products:
         
    OriGene clones in human, mouse for UST (see all 6)
    OriGene ORF clones in mouse, rat for UST
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for UST
    Sino Biological Human cDNA Clone for UST
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UST

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for UST
    Browse ESI BIO Cell Lines and PureStem Progenitors for UST 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UST


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UST_HUMAN, Q9Y2C2: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane3
    endoplasmic reticulum1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with UST           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UST About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIID - Sanfilippo syndrome D0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS I - Hurler syndrome0.45
    MPS IV - Morquio syndrome A0.45
    MPS IV - Morquio syndrome B0.45
    MPS IIIA - Sanfilippo syndrome A0.45
    MPS VII - Sly syndrome0.45
    2Chondroitin sulfate/dermatan sulfate metabolism
    Chondroitin sulfate/dermatan sulfate metabolism0.51
    Dermatan sulfate biosynthesis0.00
    Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate0.00
    3dermatan sulfate biosynthesis
    dermatan sulfate biosynthesis
    dermatan sulfate biosynthesis (late stages)0.00
    4Metabolism
    Metabolism0.38
    5Disease
    Disease


    Find genes that share SuperPaths with UST           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for UST
        dermatan sulfate biosynthesis (late stages)
    chondroitin sulfate biosynthesis (late stages)
    chondroitin sulfate biosynthesis
    dermatan sulfate biosynthesis


    1 Reactome Pathway for UST
        Dermatan sulfate biosynthesis


    1 Kegg Pathway  (Kegg details for UST):
        Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UST
    Interactions:

        Search GeneGlobe Interaction Network for UST

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for UST (Q9Y2C22, 3 ENSP000003564334) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063I2D: score=1 
    CHST11ENSP000003057254STRING: ENSP00000305725
    CHST12ENSP000002587114STRING: ENSP00000258711
    CHST13ENSP000003174044STRING: ENSP00000317404
    CHST3ENSP000003622074STRING: ENSP00000362207
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006477protein sulfation TAS10187838
    GO:0009058biosynthetic process ----
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030204chondroitin sulfate metabolic process TAS--

    Find genes that share ontologies with UST           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UST

    1 HMDB Compound for UST    About this table
    CompoundSynonyms CAS #PubMed Ids
    DermatanChondroitin sulfate B (see all 13)24967-94-0--

    1 PharmGKB related drug/compound annotation for UST gene    About this table
    Drug/compound PharmGKB Annotation
    nortriptylineCA  



    Find genes that share compounds with UST           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UST gene: 
    NM_005715.2  

    Unigene Cluster for UST:

    Uronyl-2-sulfotransferase
    Hs.657370  [show with all ESTs]
    Unigene Representative Sequence: NM_005715
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367463(uc003qmg.3) ENST00000473631 ENST00000466695
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UST using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UST (see all 65):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-21* hsa-miR-562 hsa-miR-4307 hsa-miR-379* hsa-miR-376b hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidUST 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat UST
    Clone
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    OriGene ORF clones in mouse, rat for UST
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for UST
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UST
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for UST
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UST
      QuantiTect SYBR Green Assays in human, mouse, rat UST
      QuantiFast Probe-based Assays in human, mouse, rat UST

    Additional mRNA sequence: 

    AB020316.1 AJ420554.1 AK292922.1 AK315320.1 BC093668.1 BC093694.1 

    6 DOTS entries:

    DT.95367352  DT.75101196  DT.100751424  DT.40265777  DT.75183155  DT.437676 

    Selected AceView cDNA sequences (see all 84):

    F05088 BM013565 NM_005715 Z38149 CK904728 BQ675030 AA232337 CA848699 
    AI949038 BE503701 AI093540 AI160128 CB125803 AI076049 AB020316 CA312899 
    BM931911 AI356640 BM664093 AA334103 AI371540 AL135239 AI767403 AA385129 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UST expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UST Expression
    About this image


    UST expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Brain (Nervous System)
             Oligodendrocyte Precursor Cells Forebrain White Matter
     
     Thyroid (Endocrine System)
    UST Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UST Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657370

    UniProtKB/Swiss-Prot: UST_HUMAN, Q9Y2C2
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UST

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UST gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ust1 , 5 uronyl-2-sulfotransferase1, 5 90.29(n)1
    96.3(a)1
      10 (2.65 cM)5
    3383621  NM_177387.31  NP_796361.21 
     82047535 
    chicken
    (Gallus gallus)
    Aves UST1 uronyl-2-sulfotransferase 84.62(n)
    95.36(a)
      768809  XM_001231937.3  XP_001231938.3 
    lizard
    (Anolis carolinensis)
    Reptilia UST6
    uronyl-2-sulfotransferase
    94(a)
    1 ↔ 1
    1(208867976-209027284)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ust1 uronyl-2-sulfotransferase 75.55(n)
    84.89(a)
      100496425  XM_002936257.2  XP_002936303.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ust1 uronyl-2-sulfotransferase 70.2(n)
    73.18(a)
      557218  NM_001032729.1  NP_001027901.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pip6
    pipe
    16(a)
    1 ↔ 1
    3L(19291723-19330709)


    ENSEMBL Gene Tree for UST (if available)
    TreeFam Gene Tree for UST (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UST gene
    HS2ST12  ENSG000002675612  
    1 SIMAP similar gene for UST using alignment to 1 protein entry:     UST_HUMAN:
    HS2ST1

    Find genes that share paralogs with UST           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UST (see all 6721)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1914988001,2
    --149066389(+) TAAAAC/TCCTGA 1 -- us2k10--------
    rs94981441,2
    C,F,A,H--149066460(+) CAAAAG/TATTTT 1 -- us2k1 tfbs33Minor allele frequency- T:0.45NS WA 240
    rs69201091,2
    C,F,A,H--149066468(+) TTTCTC/TTTCTC 1 -- us2k1 trp323Minor allele frequency- T:0.37NS EA NA WA CSA 2336
    rs1831105101,2
    --149066678(+) ATTCAC/TTCTTT 1 -- us2k10--------
    rs2020802051,2
    --149066678(+) ATTCA-/TTCT  
            
    TTCTT
    1 -- us2k10--------
    rs113011531,2
    C--149066707(+) CTTTC-/TTTTTT 1 -- us2k1 trp31Minor allele frequency- T:0.00CSA 2
    rs94981451,2
    C--149066777(+) cgactC/Tactgc 1 -- us2k10--------
    rs1874594661,2
    --149066858(+) CTTAAC/GGAGTA 1 -- us2k10--------
    rs1383536021,2
    --149066883(+) GATAAC/TATTTT 1 -- us2k10--------
    rs1164829561,2
    F--149066935(+) AAGGTT/CTTCAG 1 -- us2k11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for UST (149068271 - 149318271 bp, first 250kb of UST)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UST (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675997CNV Deletion23128226
    esv2732850CNV Deletion23290073
    esv2732852CNV Deletion23290073
    esv2732853CNV Deletion23290073
    esv2067920CNV Deletion18987734
    esv2672117CNV Deletion23128226
    esv2732849CNV Deletion23290073
    esv2732848CNV Deletion23290073
    esv2430067CNV Deletion19546169
    esv2666090CNV Deletion23128226

    Human Gene Mutation Database (HGMD): UST
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610752    OMIM disorders: --

    2 diseases for UST:    
    About MalaCards
    liver inflammatory pseudotumor    female stress incontinence

    2 diseases from the University of Copenhagen DISEASES database for UST:
    Female stress incontinence     Liver inflammatory pseudotumor

    Find genes that share disorders with UST           About GenesLikeMe

    Genetic Association Database (GAD): UST
    Human Genome Epidemiology (HuGE) Navigator: UST (4 documents)

    Export disorders for UST gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UST gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with UST)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a human uronyl 2- sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate. (PubMed id 10187838)1, 2, 3, 9 Kobayashi M....Rosenberg R.D. (J. Biol. Chem. 1999)
    2. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. (PubMed id 20360315)1, 4 Uher R....McGuffin P. (Am J Psychiatry 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus. (PubMed id 23620144)1 Sulkava S....Paunio T. (Hum. Mol. Genet. 2013)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    10. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10090 HGNC: 17223 AceView: UST Ensembl:ENSG00000111962 euGenes: HUgn10090
    ECgene: UST Kegg: 10090 H-InvDB: UST

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UST Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UST Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UST gene:
    Search GeneIP for patents involving UST

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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