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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UST Gene

protein-coding   GIFtS: 59
GCID: GC06P149110

uronyl-2-sulfotransferase
 Explore 5 diseases affiliated with
UST via
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Biological research products
for UST    

Aliases
for UST gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Uronyl-2-Sulfotransferase1
2OST1 2
Dermatan/Chondroitin Sulfate 2-Sulfotransferase2
Uronyl 2-Sulfotransferase2
DS2ST3
EC 2.8.2.-3

External Ids:    HGNC: 172231   Entrez Gene: 100902   Ensembl: ENSG000001119627   OMIM: 6107525   UniProtKB: Q9Y2C23   

Export aliases for UST gene to outside databases

Previous GC identifers: GC06P148721 GC06P148915 GC06P149049 GC06P146637


Summaries
for UST gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UST:
Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan
sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 (PubMed 10187838)).(supplied by OMIM,
Mar 2008)

UniProtKB/Swiss-Prot: UST_HUMAN, Q9Y2C2
Function: Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly
activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin
sulfate. Has no activity toward desulfated N-resulfated heparin




Genomic Views
for UST gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UST gene promoter:
         MEF-2A   IRF-2   ATF-2   aMEF-2   c-Jun   CUTL1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UST promoter sequence
   Search SABiosciences Chromatin IP Primers for UST

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.1   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q25.1

UST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UST gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P149110:  view genomic region     (about GC identifiers)

Start:
 149,068,271 bp from pter      End:
 149,398,126 bp from pter
Size:
 329,856 bases      Orientation:
 plus strand

Proteins
for UST gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UST_HUMAN, Q9Y2C2 (See protein sequence)
Recommended Name: Uronyl 2-sulfotransferase  
Size: 406 amino acids; 47673 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Secondary accessions: B2RCX6

Explore the universe of human proteins at neXtProt for UST: NX_Q9Y2C2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y2C2

    • UST Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005706.1  
    ENSEMBL proteins: 
     ENSP00000356433  
    Reactome Protein details: Q9Y2C2
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: UST
    OriGene Custom Protein Services for UST 
    GenScript Custom Purified and Recombinant Proteins Services for UST
    Novus Biologicals UST Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UST

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral to membrane IEA--


    UST for ontologies           About GeneDecksing



    UST Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UST 
    GenScript Superior Antibodies for UST
    Novus Biologicals UST Antibodies
    Abcam antibodies for UST 
    Uscn Antibodies for UST
    Search ThermoFisher Antibodies for UST

    Assay Products for UST: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for UST
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for UST

    Protein Domains /
    Families
    for UST gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UST for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR005331 Sulfotransferase
     IPR007734 Heparan_SO4_2-O-STrfase

    Graphical View of Domain Structure for InterPro Entry Q9Y2C2

    ProtoNet protein and cluster: Q9Y2C2

    UniProtKB/Swiss-Prot: UST_HUMAN, Q9Y2C2
    Similarity: Belongs to the sulfotransferase 3 family


    Function
    for UST gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UST_HUMAN, Q9Y2C2
    Function: Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly
    activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin
    sulfate. Has no activity toward desulfated N-resulfated heparin

    Enzyme Number (IUBMB): EC 2.8.2.-1

    miRNA
    Products:            		miRTarBase miRNAs that target UST:
    hsa-mir-1 (MIRT002811)

    OriGene 3'-UTR Clone: UST
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UST
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate UST (see all 65):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-21* hsa-miR-562 hsa-miR-4307 hsa-miR-379* hsa-miR-376b hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmid: UST 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UST (see all 7)
    OriGene shRNA RFP: UST
    OriGene siRNA: UST
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UST

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for UST

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UST (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UST
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for UST
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UST 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for UST
    Search LifeMap BioReagents cell lines for UST

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UST

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity IEA--


    UST for ontologies           About GeneDecksing



    Pathways & Interactions
    for UST gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MPS IIIC - Sanfilippo syndrome C
    8/14 pathways (see all 14)
    		MPS IIIC - Sanfilippo syndrome C1.00
    		MPS IIIA - Sanfilippo syndrome A1.00
    		MPS I - Hurler syndrome1.00
    		MPS IIID - Sanfilippo syndrome D1.00
    		Mucopolysaccharidoses1.00
    		MPS IX - Natowicz syndrome1.00
    		MPS IV - Morquio syndrome A1.00
    		MPS II - Hunter syndrome1.00
    2dermatan sulfate biosynthesis
    		dermatan sulfate biosynthesis1.00
    		chondroitin sulfate biosynthesis0.64
    		Glycosaminoglycan biosynthesis - chondroitin sulfate0.73
    		chondroitin sulfate biosynthesis (late stages)0.32
    3Disease
    		Disease1.00
    4Metabolism
    		Metabolism1.00
    5dermatan sulfate biosynthesis (late stages)
    		dermatan sulfate biosynthesis (late stages)1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4 BioSystems Pathways for UST 
        dermatan sulfate biosynthesis (late stages)
    chondroitin sulfate biosynthesis (late stages)
    chondroitin sulfate biosynthesis
    dermatan sulfate biosynthesis

    5/18        Reactome Pathways for UST (see all 18)
        Chondroitin sulfate/dermatan sulfate metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Dermatan sulfate biosynthesis


    1         Kegg Pathway  (Kegg details for UST):
        Glycosaminoglycan biosynthesis - chondroitin sulfate


    UST for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UST

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/22 Interacting proteins for UST (Q9Y2C22, 3 ENSP000003564334) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063I2D: score=1 
    BCANENSP000003312104STRING: ENSP00000331210
    CHST11ENSP000003057254STRING: ENSP00000305725
    CHST12ENSP000002587114STRING: ENSP00000258711
    CHST13ENSP000003174044STRING: ENSP00000317404
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006477protein sulfation TAS10187838
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030204chondroitin sulfate metabolic process TAS--
    GO:0030208dermatan sulfate biosynthetic process TAS--


    UST for ontologies           About GeneDecksing



    Drugs & Compounds
    for UST gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UST

    1 HMDB Compound for UST    About this table
    CompoundSynonyms CAS #PubMed Ids
    DermatanChondroitin sulfate B (see all 13)24967-94-0--
    Search CenterWatch for drugs/clinical trials and news about UST 

    Transcripts
    for UST gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UST gene: 
    NM_005715.2  

    Unigene Cluster for UST:

    Uronyl-2-sulfotransferase
    Hs.657370  [show with all ESTs]
    Unigene Representative Sequence: NM_005715
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367463(uc003qmg.3) ENST00000473631 ENST00000466695

    miRNA
    Products:             		 OriGene 3'-UTR Clone: UST
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UST
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate UST (see all 65):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-21* hsa-miR-562 hsa-miR-4307 hsa-miR-379* hsa-miR-376b hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmid: UST 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UST (see all 7)
    OriGene shRNA RFP: UST
    OriGene siRNA: UST
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UST
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UST (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UST
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for UST
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UST 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UST
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UST
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UST
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UST

    Additional cDNA sequence: 

    AB020316.1 AJ420554.1 AK292922.1 AK315320.1 BC093668.1 BC093694.1 

    6 DOTS entries:

    DT.95367352  DT.75101196  DT.100751424  DT.40265777  DT.75183155  DT.437676 

    24/84 AceView cDNA sequences (see all 84):

    CK904728 BQ675030 F01342 CA429987 BM703936 BE858525 F05088 Z38149 
    NM_005715 BM013565 AA232337 AI949038 AI767403 CA848699 AI076049 AA385129 
    AL135239 AI371540 BM664093 AA334103 AI356640 BM931911 AB020316 AI160128 

    GeneLoc Exon Structure


    Expression
    for UST gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UST expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UST expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See UST Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UST

    SOURCE GeneReport for Unigene cluster: Hs.657370

    UniProtKB/Swiss-Prot: UST_HUMAN, Q9Y2C2
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for UST
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UST
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UST

    Orthologs
    for UST gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for UST gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ust1 , 5 uronyl-2-sulfotransferase1, 5 90.29(n)1
    96.3(a)1    		   10 (2.65 cM)5
    3383621  NM_177387.31  NP_796361.21 
     82047535 
    chicken
    (Gallus gallus)    		 Aves UST1 uronyl-2-sulfotransferase 84.62(n)
    95.36(a)    		   768809  XM_001231937.2  XP_001231938.2 
    lizard
    (Anolis carolinensis)    		 Reptilia UST6
    		 --
    		 94(a)
    		 1 ↔ 1
    		 1(208868650-209017422)
    zebrafish
    (Danio rerio)    		 Actinopterygii ust1 uronyl-2-sulfotransferase 70.2(n)
    73.18(a)    		   557218  NM_001032729.1  NP_001027901.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta pip6
    		 pipe
    		 16(a)
    		 1 ↔ 1
    		 3L(19291723-19330709)


    ENSEMBL Gene Tree for UST (if available)
    TreeFam Gene Tree for UST (if available) 

    Paralogs
    for UST gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UST gene
    HS2ST12  ENSG000002675612  
    1 SIMAP similar gene for UST using alignment to 1 protein entry:     UST_HUMAN:
    HS2ST1

    UST for paralogs           About GeneDecksing



    Genomic Variants
    for UST gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6027 NCBI SNPs in UST are shown (see all 6027)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1914988001,2
    		--149066389(+) TAAAAC/TCCTGA 1 -- us2k10--------
    rs94981441,2
    		C,A,H,--149066460(+) CAAAAG/TATTTT 1 -- us2k1 tfbs33Minor allele frequency- T:0.45NS WA 240
    rs69201091,2
    		C,F,A,H,--149066468(+) TTTCTC/TTTCTC 1 -- us2k1 trp323Minor allele frequency- T:0.37NS EA NA WA CSA 2336
    rs1831105101,2
    		--149066678(+) ATTCAC/TTCTTT 1 -- us2k10--------
    rs2020802051,2
    		--149066678(+) ATTCA-/TTCT  
                TTCTT     		1 -- us2k10--------
    rs113011531,2
    		C--149066707(+) CTTTC-/TTTTTT 1 -- us2k1 trp31Minor allele frequency- T:0.00CSA 2
    rs94981451,2
    		--149066777(+) cgactC/Tactgc 1 -- us2k10--------
    rs1874594661,2
    		--149066858(+) CTTAAC/GGAGTA 1 -- us2k10--------
    rs1383536021,2
    		--149066883(+) GATAAC/TATTTT 1 -- us2k10--------
    rs1164829561,2
    		F,--149066935(+) AAGGTT/CTTCAG 1 -- us2k11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for UST (149068271 - 149318271 bp, first 250kb of UST)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 12 variations for UST
         8 CNVs: 30244 94086 81633 81634 69615 94085 69614 99747
         4 Indels: 40927 94087 94089 94088
    Human Gene Mutation Database (HGMD): UST

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UST
    DNA2.0 Custom Variant and Variant Library Synthesis for UST

    Disorders / Diseases
    for UST gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UST for disorders           About GeneDecksing

    OMIM gene information: 610752    OMIM disorders: --

    5 diseases for UST:    About MalaCards
    female stress incontinence    specific phobia    liver inflammatory pseudotumor    calcific tendinitis
    phobia

    2 diseases from the University of Copenhagen DISEASES database for UST:
    Female stress incontinence     Liver inflammatory pseudotumor
    Human Genome Epidemiology (HuGE) Navigator: UST (4 documents)

    Export disorders for UST gene to outside databases

    Publications
    for UST gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UST gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with UST)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a human uronyl 2- sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate. (PubMed id 10187838)1, 2, 3, 9 Kobayashi M....Rosenberg R.D. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. Genome-wide pharmacogenetics of antidepressant respon se in the GENDEP project. (PubMed id 20360315)1 Uher R....McGuffin P. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    8. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    10. Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase. (PubMed id 17227754)1 Xu D....Liu J. (2007)

    External Searches for UST gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing UST gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10090 HGNC: 17223 AceView: UST Ensembl:ENSG00000111962 euGenes: HUgn10090
    ECgene: UST Kegg: 10090 H-InvDB: UST

    Other Databases showing UST gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UST gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UST Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UST Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for UST gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UST gene:
    Search GeneIP for patents involving UST

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