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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UST Gene

protein-coding   GIFtS: 61
GCID: GC06P149110

Uronyl-2-Sulfotransferase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
uronyl-2-sulfotransferase1 2
2OST2
Dermatan/Chondroitin Sulfate 2-Sulfotransferase2
Uronyl 2-Sulfotransferase2
DS2ST3
EC 2.8.2.-3

External Ids:    HGNC: 172231   Entrez Gene: 100902   Ensembl: ENSG000001119627   OMIM: 6107525   UniProtKB: Q9Y2C23   

Export aliases for UST gene to outside databases

Previous GC identifers: GC06P148721 GC06P148915 GC06P149049 GC06P146637


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UST Gene:
Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in
dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 (PubMed
10187838)).(supplied by OMIM, Mar 2008)

GeneCards Summary for UST Gene: 
UST (uronyl-2-sulfotransferase) is a protein-coding gene. Diseases associated with UST include liver inflammatory pseudotumor, and calcific tendinitis, and among its related super-pathways are chondroitin sulfate biosynthesis and Metabolism of carbohydrates. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is HS2ST1.

UniProtKB/Swiss-Prot: UST_HUMAN, Q9Y2C2
Function: Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly
activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of
chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UST gene promoter:
         MEF-2A   IRF-2   ATF-2   aMEF-2   c-Jun   CUTL1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UST promoter sequence
   Search SABiosciences Chromatin IP Primers for UST

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.1   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q25.1

UST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UST gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P149110:  view genomic region     (about GC identifiers)

Start:
149,068,271 bp from pter      End:
149,398,126 bp from pter
Size:
329,856 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UST_HUMAN, Q9Y2C2 (See protein sequence)
Recommended Name: Uronyl 2-sulfotransferase  
Size: 406 amino acids; 47673 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Secondary accessions: B2RCX6

Explore the universe of human proteins at neXtProt for UST: NX_Q9Y2C2

Explore proteomics data for UST at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2C2

  • UST Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UST Protein Expression
    REFSEQ proteins: NP_005706.1  
    ENSEMBL proteins: 
     ENSP00000356433  
    Reactome Protein details: Q9Y2C2
    Human Recombinant Protein Products for UST: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for UST
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    Novus Biologicals UST Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UST 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus ----
    GO:0016021integral to membrane IEA--

    UST for ontologies           About GeneDecksing



    UST Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for UST 

    Assay Products for UST: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UST 
    Cloud-Clone Corp. CLIAs for UST


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SULTM: Sulfotransferases, membrane-bound

    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR005331 Sulfotransferase
     IPR007734 Heparan_SO4_2-O-STrfase

    Graphical View of Domain Structure for InterPro Entry Q9Y2C2

    ProtoNet protein and cluster: Q9Y2C2

    UniProtKB/Swiss-Prot: UST_HUMAN, Q9Y2C2
    Similarity: Belongs to the sulfotransferase 3 family


    UST for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UST_HUMAN, Q9Y2C2
    Function: Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly
    activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of
    chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin

         Enzyme Number (IUBMB): EC 2.8.2.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001733galactosylceramide sulfotransferase activity ----
    GO:0008146sulfotransferase activity IEA--
         
    UST for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UST 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UST

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UST 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UST 

    miRNA
    Products:
        
    miRTarBase miRNAs that target UST:
    hsa-mir-1 (MIRT002811)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UST
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate UST (see all 65):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-21* hsa-miR-562 hsa-miR-4307 hsa-miR-379* hsa-miR-376b hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidUST 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of UST

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UST


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UST About   (see all 7)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1chondroitin sulfate biosynthesis
    chondroitin sulfate biosynthesis0.74
    chondroitin sulfate biosynthesis (late stages)0.65
    Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate0.74
    dermatan sulfate biosynthesis0.64
    2MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Glycosaminoglycan metabolism0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS I - Hurler syndrome0.48
    MPS IV - Morquio syndrome B0.48
    MPS IX - Natowicz syndrome0.48
    3A tetrasaccharide linker sequence is required for GAG synthesis
    Chondroitin sulfate/dermatan sulfate metabolism0.54
    4CS/DS degradation
    Dermatan sulfate biosynthesis0.44
    5Metabolism
    Metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for UST
        chondroitin sulfate biosynthesis (late stages)
    dermatan sulfate biosynthesis (late stages)
    chondroitin sulfate biosynthesis
    dermatan sulfate biosynthesis

    5/18        Reactome Pathways for UST (see all 18)
        Chondroitin sulfate/dermatan sulfate metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Dermatan sulfate biosynthesis


    1         Kegg Pathway  (Kegg details for UST):
        Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate


    UST for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UST

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/22 Interacting proteins for UST (Q9Y2C22, 3 ENSP000003564334) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063I2D: score=1 
    BCANENSP000003312104STRING: ENSP00000331210
    CHST11ENSP000003057254STRING: ENSP00000305725
    CHST12ENSP000002587114STRING: ENSP00000258711
    CHST13ENSP000003174044STRING: ENSP00000317404
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006477protein sulfation TAS10187838
    GO:0009058biosynthetic process ----
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030204chondroitin sulfate metabolic process TAS--

    UST for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UST

    1 HMDB Compound for UST    About this table
    CompoundSynonyms CAS #PubMed Ids
    DermatanChondroitin sulfate B (see all 13)24967-94-0--

    Search CenterWatch for drugs/clinical trials and news about UST

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UST gene: 
    NM_005715.2  

    Unigene Cluster for UST:

    Uronyl-2-sulfotransferase
    Hs.657370  [show with all ESTs]
    Unigene Representative Sequence: NM_005715
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367463(uc003qmg.3) ENST00000473631 ENST00000466695
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UST
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate UST (see all 65):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-21* hsa-miR-562 hsa-miR-4307 hsa-miR-379* hsa-miR-376b hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidUST 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UST
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UST
    Clone
    Products:
         
    OriGene clones in human, mouse for UST (see all 7)
    OriGene ORF clones in mouse, rat for UST
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for UST
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UST
    Sirion Biotech Customized lentivirus for stable overexpression of UST 
                         Customized lentivirus expression plasmids for stable overexpression of UST 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for UST
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UST
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UST

    Additional mRNA sequence: 

    AB020316.1 AJ420554.1 AK292922.1 AK315320.1 BC093668.1 BC093694.1 

    6 DOTS entries:

    DT.95367352  DT.75101196  DT.100751424  DT.40265777  DT.75183155  DT.437676 

    24/84 AceView cDNA sequences (see all 84):

    AA334103 AI371540 AL135239 AI767403 AA385129 BE858525 CA429987 F01342 
    BM703936 F05088 BM013565 NM_005715 Z38149 CK904728 BQ675030 AA232337 
    CA848699 AI949038 BE503701 AI093540 AI160128 CB125803 AI076049 AB020316 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UST expression in normal human tissues (normalized intensities)      UST embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UST Expression
    About this image


    UST expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             lateral substantia nigra   
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod

    See UST Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UST

    SOURCE GeneReport for Unigene cluster: Hs.657370

    UniProtKB/Swiss-Prot: UST_HUMAN, Q9Y2C2
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for UST
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UST

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UST gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ust1 , 5 uronyl-2-sulfotransferase1, 5 90.29(n)1
    96.3(a)1
      10 (2.65 cM)5
    3383621  NM_177387.31  NP_796361.21 
     82047535 
    chicken
    (Gallus gallus)
    Aves UST1 uronyl-2-sulfotransferase 84.62(n)
    95.36(a)
      768809  XM_001231937.2  XP_001231938.2 
    lizard
    (Anolis carolinensis)
    Reptilia UST6
    Uncharacterized protein
    94(a)
    1 ↔ 1
    1(208867976-209027284)
    zebrafish
    (Danio rerio)
    Actinopterygii ust1 uronyl-2-sulfotransferase 70.2(n)
    73.18(a)
      557218  NM_001032729.1  NP_001027901.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pip6
    pipe
    15(a)
    1 ↔ 1
    3L(19291723-19330709)


    ENSEMBL Gene Tree for UST (if available)
    TreeFam Gene Tree for UST (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UST gene
    HS2ST12  ENSG000002675612  
    1 SIMAP similar gene for UST using alignment to 1 protein entry:     UST_HUMAN:
    HS2ST1

    UST for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6721 SNPs in UST are shown (see all 6721)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1914988001,2
    --149066389(+) TAAAAC/TCCTGA 1 -- us2k10--------
    rs94981441,2
    C,F,A,H--149066460(+) CAAAAG/TATTTT 1 -- us2k1 tfbs33Minor allele frequency- T:0.45NS WA 240
    rs69201091,2
    C,F,A,H--149066468(+) TTTCTC/TTTCTC 1 -- us2k1 trp323Minor allele frequency- T:0.37NS EA NA WA CSA 2336
    rs1831105101,2
    --149066678(+) ATTCAC/TTCTTT 1 -- us2k10--------
    rs2020802051,2
    --149066678(+) ATTCA-/TTCT  
            
    TTCTT
    1 -- us2k10--------
    rs113011531,2
    C--149066707(+) CTTTC-/TTTTTT 1 -- us2k1 trp31Minor allele frequency- T:0.00CSA 2
    rs94981451,2
    C--149066777(+) cgactC/Tactgc 1 -- us2k10--------
    rs1874594661,2
    --149066858(+) CTTAAC/GGAGTA 1 -- us2k10--------
    rs1383536021,2
    --149066883(+) GATAAC/TATTTT 1 -- us2k10--------
    rs1164829561,2
    F--149066935(+) AAGGTT/CTTCAG 1 -- us2k11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for UST (149068271 - 149318271 bp, first 250kb of UST)

    Structural Variations
         Database of Genomic Variants (DGV) 10/22 variations for UST (see all 22):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675997CNV Deletion23128226
    esv2732850CNV Deletion23290073
    esv2732852CNV Deletion23290073
    esv2732853CNV Deletion23290073
    esv2067920CNV Deletion18987734
    esv2672117CNV Deletion23128226
    esv2732849CNV Deletion23290073
    esv2732848CNV Deletion23290073
    esv2430067CNV Deletion19546169
    esv2666090CNV Deletion23128226


    Human Gene Mutation Database (HGMD): UST
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UST
    DNA2.0 Custom Variant and Variant Library Synthesis for UST

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610752    OMIM disorders: --

    5 diseases for UST:    About MalaCards
    liver inflammatory pseudotumor    calcific tendinitis    female stress incontinence    specific phobia
    morquio syndrome b

    2 diseases from the University of Copenhagen DISEASES database for UST:
    Female stress incontinence     Liver inflammatory pseudotumor

    UST for disorders           About GeneDecksing

    Genetic Association Database (GAD): UST
    Human Genome Epidemiology (HuGE) Navigator: UST (4 documents)

    Export disorders for UST gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UST gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with UST)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a human uronyl 2- sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate. (PubMed id 10187838)1, 2, 3, 9 Kobayashi M....Rosenberg R.D. (1999)
    2. Genome-wide pharmacogenetics of antidepressant respon se in the GENDEP project. (PubMed id 20360315)1, 4 Uher R....McGuffin P. (2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus. (PubMed id 23620144)1 Sulkava S....Paunio T. (2013)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
    10. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10090 HGNC: 17223 AceView: UST Ensembl:ENSG00000111962 euGenes: HUgn10090
    ECgene: UST Kegg: 10090 H-InvDB: UST

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UST Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UST Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UST gene:
    Search GeneIP for patents involving UST

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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