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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USPL1 Gene

protein-coding   GIFtS: 47
GCID: GC13P031191

ubiquitin specific peptidase like 1

(Previous name: chromosome 13 open reading frame 22 )
(Previous symbol: C13orf22)
 Explore 1 disease affiliated with
USPL1 via our new
 Human Malady Compendium 
Biological research products
for USPL1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase Like 11 2     RP11-121O19.12
C13orf221 2 3     Highly Charged Protein2
D13S106E1 2     SUMO-Specific Isopeptidase USPL12
BA121O19.11     D13S1063
Ubiquitin-Specific Peptidase-Like Protein 12 3     EC 3.4.22.-3
Chromosome 13 Open Reading Frame 221     

External Ids:    HGNC: 202941   Entrez Gene: 102082   Ensembl: ENSG000001329527   UniProtKB: Q5W0Q73   

Export aliases for USPL1 gene to outside databases

Previous GC identifers: GC13P030090 GC13P012009


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: USPL1_HUMAN, Q5W0Q7
Function: SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher
affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to
their mature forms. May have non-catalytic functions in Cajal bodies organization and cell proliferation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USPL1 gene promoter:
         p53   SREBP-1c   POU3F2   SREBP-1b   Gfi-1   MEF-2A   PPAR-gamma1   SREBP-1a   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSPL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for USPL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USPL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12-q14   Ensembl cytogenetic band:  13q12.3   HGNC cytogenetic band: 13q12-q14

USPL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USPL1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P031191:  view genomic region     (about GC identifiers)

Start:
31,191,830 bp from pter      End:
31,233,686 bp from pter
Size:
41,857 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: USPL1_HUMAN, Q5W0Q7 (See protein sequence)
Recommended Name: SUMO-specific isopeptidase USPL1  
Size: 1092 amino acids; 120440 Da
Subcellular location: Nucleus, Cajal body
Secondary accessions: Q14109 Q6AI45 Q8IY30 Q8IYE8
Alternative splicing: 2 isoforms:  Q5W0Q7-1   Q5W0Q7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USPL1: NX_Q5W0Q7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5W0Q7

  • USPL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005791.3  
    ENSEMBL proteins: 
     ENSP00000255304  

    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for USPL1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015030Cajal body IDA--


    USPL1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for USPL1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    USPL1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001394 Peptidase_C19

    Graphical View of Domain Structure for InterPro Entry Q5W0Q7

    ProtoNet protein and cluster: Q5W0Q7

    UniProtKB/Swiss-Prot: USPL1_HUMAN, Q5W0Q7
    Similarity: Belongs to the peptidase C19 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: USPL1_HUMAN, Q5W0Q7
    Function: SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher
    affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to
    their mature forms. May have non-catalytic functions in Cajal bodies organization and cell proliferation

    Enzyme Number (IUBMB): EC 3.4.22.-1

    miRNA
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    Inhib. RNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IEA--
    GO:0032183SUMO binding IDA--
    GO:0043130NOT ubiquitin binding IDA--
    GO:0070140SUMO-specific isopeptidase activity IDA--


    USPL1 for ontologies           About GeneDecksing


    7 GenomeRNAi human phenotypes for USPL1:
     Decreased Wnt reporter activit  Decreased cell number, increas  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 
     Increased gamma-H2AX phosphory  Increased number of mitotic ce  Synthetic lethal with Ras 

    Animal Models:
         1 MGI phenotypic allele for Uspl1 (no phenotypes)

    USPL1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USPL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/18 Interacting proteins for USPL1 (Q5W0Q72, 3 ENSP000002553044) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO3P558542MINT-8406214 MINT-8406704 MINT-8406783 MINT-8406250 MINT-8403906 MINT-8406769 MINT-8406198 MINT-8404150 MINT-8406021 MINT-8406733 MINT-8406233 MINT-8404174 MINT-8406294
    SUMO1P631652MINT-8404163 MINT-8403978 MINT-8406010 MINT-8403747 MINT-8404137
    CKBP122773, ENSP000002991984I2D: score=2 STRING: ENSP00000299198
    ELLP551993, ENSP000002628094I2D: score=2 STRING: ENSP00000262809
    KRT85P783863, ENSP000002579014I2D: score=2 STRING: ENSP00000257901
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0008283cell proliferation IMP--
    GO:0016926protein desumoylation IDA--
    GO:0030576Cajal body organization IMP--


    USPL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USPL1
    Search CenterWatch for drugs/clinical trials and news about USPL1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USPL1 gene: 
    NM_005800.4  

    Unigene Cluster for USPL1:

    Ubiquitin specific peptidase like 1
    Hs.533831  [show with all ESTs]
    Unigene Representative Sequence: AL832776
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465952 ENST00000255304(uc001utb.3 uc001utc.2 uc001utd.2 uc001ute.1)


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    Inhib. RNA
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    Additional cDNA sequence: 

    AK057514.1 AK289826.1 AL832776.1 BC012594.1 BC036027.1 BC038103.2 CR627370.1 X59131.1 

    13 DOTS entries:

    DT.414948  DT.97816063  DT.100697429  DT.100778291  DT.95138020  DT.92068129  DT.100712914  DT.86849795 
    DT.120795193  DT.91747034  DT.120795194  DT.120795256  DT.100733811 

    24/122 AceView cDNA sequences (see all 122):

    BX332183 BQ447200 BX390720 BX492656 AL529833 BC012594 AA250746 AL555440 
    AW614152 CR627370 AI468024 BU624850 AA810238 BG698085 BM977282 AL041997 
    BM478607 BQ212795 BM021398 AA748739 CB130306 BQ002506 AI091449 CB216080 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for USPL1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^
    SP1:                          -     -     -     -     -                                                                 -     -     -           -               
    SP2:                                                                                                                                            -               
    SP3:                                                                                                                                            -               
    SP4:                          -     -     -     -                                                                                                               
    SP5:                                            -                                                                                                               

    ExUns: 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:  -                                 
    SP2:  -                                 
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for USPL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USPL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAATCTTTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See USPL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USPL1

    SOURCE GeneReport for Unigene cluster: Hs.533831
        SABiosciences Custom PCR Arrays for USPL1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USPL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for USPL1 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uspl11 , 5 ubiquitin specific peptidase like 11, 5 74.29(n)1
    62.65(a)1
      5 (89.18 cM)5
    2319151  NM_001115149.11  NP_001108621.11 
     1491843505 
    chicken
    (Gallus gallus)
    Aves USPL11 ubiquitin specific peptidase like 1 54.67(n)
    39.7(a)
      395436  NM_001162393.1  NP_001155865.1 
    lizard
    (Anolis carolinensis)
    Reptilia USPL16
    --
    35(a)
    1 ↔ 1
    3(184521305-184530186)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377317662   -- 75(n)    137731766 
    zebrafish
    (Danio rerio)
    Actinopterygii uspl16
    ubiquitin specific peptidase like 1
    24(a)
    1 ↔ 1
    10(37683374-37700066)


    ENSEMBL Gene Tree for USPL1 (if available)
    TreeFam Gene Tree for USPL1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/699 NCBI SNPs in USPL1 are shown (see all 699    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1155214981,2
    --31189835(+) GCAAGT/CAGCTT 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1379457881,2
    C,--31189853(+) CCAGG-/TTTGGG 1 -- us2k10--------
    rs1915049971,2
    --31189938(+) TGAGAC/GAAAAA 1 -- us2k10--------
    rs771079271,2
    --31189962(+) AATCAT/CACAGA 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1843365831,2
    --31190090(+) ACAAGA/CGATGG 1 -- us2k10--------
    rs1875288421,2
    --31190154(+) ATATGC/TAGAAA 1 -- us2k10--------
    rs1145622411,2
    F,--31190173(+) TCAAAT/CATATA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1475393301,2
    --31190183(+) AGGAAC/TAACCA 1 -- us2k10--------
    rs1930906411,2
    --31190243(+) CGAAAA/GGGGTT 1 -- us2k10--------
    rs1393554651,2
    --31190260(+) TCAATC/GTCTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for USPL1 (31191830 - 31233686 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for USPL1
         2 CNVs: 86765 66410

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    USPL1 for disorders           About GeneDecksing

    1 disease for USPL1:    About MalaCards
    neurodegenerative disease


    Export disorders for USPL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USPL1 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with USPL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions. (PubMed id 22878415)1, 2, 3 Schulz S.... Melchior F. (2012)
    2. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    9. Electrostatic effects in highly charged proteins: salt sensitivity of pKa values of histidines in staphylococcal nuclease. (PubMed id 11969427)9 Lee K.K....Garcia-Moreno E B. (2002)
    10. Molecular mechanisms of alpha-synuclein neurodegenera tion. (PubMed id 18955133)9 Waxman E.A. and Giasson B.I. (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10208 HGNC: 20294 AceView: C13orf22 Ensembl:ENSG00000132952 euGenes: HUgn10208
    ECgene: USPL1 H-InvDB: USPL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USPL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USPL1 gene:
    Search GeneIP for patents involving USPL1

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