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Aliases for USPL1 Gene

Aliases for USPL1 Gene

  • Ubiquitin Specific Peptidase Like 1 2 3 5
  • Ubiquitin-Specific Peptidase-Like Protein 1 3 4
  • USP-Like 1 3 4
  • C13orf22 3 4
  • Chromosome 13 Open Reading Frame 22 2
  • SUMO-Specific Isopeptidase USPL1 3
  • Highly Charged Protein 3
  • EC 3.4.22.- 4
  • BA121O19.1 3
  • D13S106E 3
  • D13S106 4

External Ids for USPL1 Gene

Previous HGNC Symbols for USPL1 Gene

  • C13orf22

Previous GeneCards Identifiers for USPL1 Gene

  • GC13P030090
  • GC13P031191
  • GC13P012009

Summaries for USPL1 Gene

GeneCards Summary for USPL1 Gene

USPL1 (Ubiquitin Specific Peptidase Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin binding and SUMO-specific isopeptidase activity.

UniProtKB/Swiss-Prot for USPL1 Gene

  • SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172).

Additional gene information for USPL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USPL1 Gene

Genomics for USPL1 Gene

GeneHancer (GH) Regulatory Elements for USPL1 Gene

Promoters and enhancers for USPL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I030615 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 593.6 -0.1 -115 4.9 MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 USPL1 HMGB1 LINC01058 RBM22P2 UBE2L5 MFAP1P1 PTPN2P2
GH13I030844 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 46.6 +229.1 229065 4.8 HDGF PKNOX1 FOXA2 MLX ARID4B FEZF1 ZNF2 ZNF48 ATF7 FOS USPL1 LINC01058 HMGB1 MEDAG LOC105370145 PIR60604 LINC00545
GH13I030462 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 22.7 -152.9 -152871 5.3 HDGF FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 HMGB1 USPL1 LINC01058 KATNAL1 UBL3 GC13M030460 MFAP1P1
GH13I030393 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 26.6 -222.4 -222397 3 PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 ATF7 USPL1 LINC01058 HMGB1 KATNAL1 LINC00426
GH13I030306 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 15.4 -310.2 -310173 3 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 POLR2B ZNF766 E2F8 KATNAL1 USPL1 LINC01058 LINC00427
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around USPL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the USPL1 gene promoter:

Genomic Locations for USPL1 Gene

Genomic Locations for USPL1 Gene
chr13:30,617,693-30,660,770
(GRCh38/hg38)
Size:
43,078 bases
Orientation:
Plus strand
chr13:31,191,830-31,233,686
(GRCh37/hg19)

Genomic View for USPL1 Gene

Genes around USPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USPL1 Gene

Proteins for USPL1 Gene

  • Protein details for USPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5W0Q7-USPL1_HUMAN
    Recommended name:
    SUMO-specific isopeptidase USPL1
    Protein Accession:
    Q5W0Q7
    Secondary Accessions:
    • Q14109
    • Q6AI45
    • Q8IY30
    • Q8IYE8

    Protein attributes for USPL1 Gene

    Size:
    1092 amino acids
    Molecular mass:
    120440 Da
    Quaternary structure:
    • Interacts with ELL.

    Alternative splice isoforms for USPL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USPL1 Gene

Post-translational modifications for USPL1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for USPL1 Gene

Domains & Families for USPL1 Gene

Gene Families for USPL1 Gene

Protein Domains for USPL1 Gene

Suggested Antigen Peptide Sequences for USPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5W0Q7

UniProtKB/Swiss-Prot:

USPL1_HUMAN :
  • Belongs to the peptidase C19 family.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USPL1: view

Function for USPL1 Gene

Molecular function for USPL1 Gene

UniProtKB/Swiss-Prot Function:
SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172).

Enzyme Numbers (IUBMB) for USPL1 Gene

Phenotypes From GWAS Catalog for USPL1 Gene

Gene Ontology (GO) - Molecular Function for USPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0032183 SUMO binding IEA,IDA 22878415
genes like me logo Genes that share ontologies with USPL1: view
genes like me logo Genes that share phenotypes with USPL1: view

Animal Model Products

miRNA for USPL1 Gene

miRTarBase miRNAs that target USPL1

Clone Products

  • Addgene plasmids for USPL1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USPL1 Gene

Localization for USPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USPL1 Gene

Nucleus, Cajal body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USPL1 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 3
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for USPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA,IDA 22664934
GO:0005634 nucleus IEA --
GO:0015030 Cajal body IDA,IEA 22878415
genes like me logo Genes that share ontologies with USPL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for USPL1 Gene

Pathways & Interactions for USPL1 Gene

SuperPathways for USPL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for USPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008283 cell proliferation IMP 22878415
GO:0016926 protein desumoylation IDA 22878415
GO:0030576 Cajal body organization IMP 22878415
genes like me logo Genes that share ontologies with USPL1: view

No data available for Pathways by source and SIGNOR curated interactions for USPL1 Gene

Drugs & Compounds for USPL1 Gene

No Compound Related Data Available

Transcripts for USPL1 Gene

Unigene Clusters for USPL1 Gene

Ubiquitin specific peptidase like 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for USPL1

Alternative Splicing Database (ASD) splice patterns (SP) for USPL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^
SP1: - - - - - - - - -
SP2: -
SP3: -
SP4: - - - -
SP5: -
SP6:
SP7: - - - - - -
SP8:
SP9: - - - - - - -
SP10: - - - -

ExUns: 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for USPL1 Gene

GeneLoc Exon Structure for
USPL1
ECgene alternative splicing isoforms for
USPL1

Expression for USPL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of USPL1 Gene:

USPL1

SOURCE GeneReport for Unigene cluster for USPL1 Gene:

Hs.533831

Evidence on tissue expression from TISSUES for USPL1 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with USPL1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for USPL1 Gene

Orthologs for USPL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for USPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USPL1 33 34
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia USPL1 33 34
  • 84.7 (n)
cow
(Bos Taurus)
Mammalia USPL1 33 34
  • 82.03 (n)
mouse
(Mus musculus)
Mammalia Uspl1 33 16 34
  • 73.68 (n)
rat
(Rattus norvegicus)
Mammalia Uspl1 33
  • 72.92 (n)
oppossum
(Monodelphis domestica)
Mammalia USPL1 34
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USPL1 34
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves USPL1 33 34
  • 56.35 (n)
lizard
(Anolis carolinensis)
Reptilia USPL1 34
  • 36 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii uspl1 34
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToOne
Species where no ortholog for USPL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USPL1 Gene

ENSEMBL:
Gene Tree for USPL1 (if available)
TreeFam:
Gene Tree for USPL1 (if available)

Paralogs for USPL1 Gene

No data available for Paralogs for USPL1 Gene

Variants for USPL1 Gene

Sequence variations from dbSNP and Humsavar for USPL1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000078493 -- 30,630,086(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000094358 -- 30,649,823(+) G/A intron_variant
rs1000143927 -- 30,656,831(+) T/C intron_variant
rs1000374556 -- 30,636,463(+) G/A intron_variant
rs1000446514 -- 30,650,119(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for USPL1 Gene

Variant ID Type Subtype PubMed ID
esv24978 CNV loss 19812545
esv2670401 CNV deletion 23128226
esv2747224 CNV deletion 23290073
esv3550265 CNV deletion 23714750
esv3631679 CNV loss 21293372
nsv1122800 CNV deletion 24896259
nsv832573 CNV gain 17160897
nsv832574 CNV gain 17160897

Variation tolerance for USPL1 Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.36; 90.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USPL1 Gene

Human Gene Mutation Database (HGMD)
USPL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
USPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USPL1 Gene

Disorders for USPL1 Gene

Additional Disease Information for USPL1

No disorders were found for USPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USPL1 Gene

Publications for USPL1 Gene

  1. Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions. (PMID: 22878415) Schulz S … Melchior F (EMBO reports 2012) 2 3 4 58
  2. A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II. (PMID: 24413172) Hutten S … Lamond AI (Journal of cell science 2014) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58

Products for USPL1 Gene

  • Addgene plasmids for USPL1

Sources for USPL1 Gene

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