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Aliases for USPL1 Gene

Aliases for USPL1 Gene

  • Ubiquitin Specific Peptidase Like 1 2 3 5
  • Ubiquitin-Specific Peptidase-Like Protein 1 3 4
  • C13orf22 3 4
  • Chromosome 13 Open Reading Frame 22 2
  • SUMO-Specific Isopeptidase USPL1 3
  • Highly Charged Protein 3
  • EC 3.4.22.- 4
  • BA121O19.1 3
  • D13S106E 3
  • D13S106 4

External Ids for USPL1 Gene

Previous HGNC Symbols for USPL1 Gene

  • C13orf22

Previous GeneCards Identifiers for USPL1 Gene

  • GC13P030090
  • GC13P031191
  • GC13P012009

Summaries for USPL1 Gene

GeneCards Summary for USPL1 Gene

USPL1 (Ubiquitin Specific Peptidase Like 1) is a Protein Coding gene. GO annotations related to this gene include ubiquitin binding and SUMO-specific isopeptidase activity.

UniProtKB/Swiss-Prot for USPL1 Gene

  • SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. May have non-catalytic functions in Cajal bodies organization and cell proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USPL1 Gene

Genomics for USPL1 Gene

Regulatory Elements for USPL1 Gene

Enhancers for USPL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F030672 1.3 Ensembl ENCODE 23.3 +56.5 56530 2.6 CREB3L1 WRNIP1 ARID4B SIN3A YY1 ZNF143 ZNF207 FOS KLF13 SP3 USPL1 LINC01058 HMGB1 MFAP1P1 TRN-GTT2-4 ENSG00000275788
GH13F030615 1.2 ENCODE 22.2 -0.1 -115 4.9 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 USPL1 MEDAG LINC01058 HMGB1 PTPN2P2
GH13F030844 1.6 FANTOM5 Ensembl ENCODE 16.3 +229.1 229065 4.8 HDGF PKNOX1 MLX ARID4B FEZF1 ZNF48 ZNF2 FOS SP5 NFYC LINC01058 USPL1 MEDAG LOC105370145 UBE2L5P HMGB1 PIR60604 LINC00545
GH13F030711 1.4 FANTOM5 Ensembl ENCODE 15.5 +95.9 95908 4.4 CTCF JUN MAX POLR2A SCRT2 FOS ETV6 NR2F6 ZSCAN29 CREM ALOX5AP USPL1 HMGB1 LINC00398
GH13F030393 1.6 FANTOM5 Ensembl ENCODE 13.1 -222.4 -222398 3.0 PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 FOS ZHX2 REST USPL1 HMGB1 KATNAL1 LINC00426 LINC01058
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around USPL1 on UCSC Golden Path with GeneCards custom track

Promoters for USPL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000513763 7 5401 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263

Genomic Location for USPL1 Gene

Chromosome:
13
Start:
30,617,693 bp from pter
End:
30,660,770 bp from pter
Size:
43,078 bases
Orientation:
Plus strand

Genomic View for USPL1 Gene

Genes around USPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USPL1 Gene

Proteins for USPL1 Gene

  • Protein details for USPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5W0Q7-USPL1_HUMAN
    Recommended name:
    SUMO-specific isopeptidase USPL1
    Protein Accession:
    Q5W0Q7
    Secondary Accessions:
    • Q14109
    • Q6AI45
    • Q8IY30
    • Q8IYE8

    Protein attributes for USPL1 Gene

    Size:
    1092 amino acids
    Molecular mass:
    120440 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for USPL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USPL1 Gene

Post-translational modifications for USPL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for USPL1 Gene

Domains & Families for USPL1 Gene

Protein Domains for USPL1 Gene

Suggested Antigen Peptide Sequences for USPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5W0Q7

UniProtKB/Swiss-Prot:

USPL1_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USPL1: view

Function for USPL1 Gene

Molecular function for USPL1 Gene

UniProtKB/Swiss-Prot Function:
SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. May have non-catalytic functions in Cajal bodies organization and cell proliferation.

Enzyme Numbers (IUBMB) for USPL1 Gene

Gene Ontology (GO) - Molecular Function for USPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0032183 SUMO binding IDA 22878415
genes like me logo Genes that share ontologies with USPL1: view
genes like me logo Genes that share phenotypes with USPL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for USPL1

miRNA for USPL1 Gene

miRTarBase miRNAs that target USPL1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USPL1 Gene

Localization for USPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USPL1 Gene

Nucleus, Cajal body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USPL1 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 3
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for USPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IEA --
GO:0015030 Cajal body IEA,IDA 22878415
genes like me logo Genes that share ontologies with USPL1: view

Pathways & Interactions for USPL1 Gene

SuperPathways for USPL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for USPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008283 cell proliferation IMP 22878415
GO:0016926 protein desumoylation IDA 22878415
GO:0030576 Cajal body organization IMP 22878415
genes like me logo Genes that share ontologies with USPL1: view

No data available for Pathways by source and SIGNOR curated interactions for USPL1 Gene

Transcripts for USPL1 Gene

Unigene Clusters for USPL1 Gene

Ubiquitin specific peptidase like 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USPL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^
SP1: - - - - - - - - -
SP2: -
SP3: -
SP4: - - - -
SP5: -
SP6:
SP7: - - - - - -
SP8:
SP9: - - - - - - -
SP10: - - - -

ExUns: 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for USPL1 Gene

GeneLoc Exon Structure for
USPL1
ECgene alternative splicing isoforms for
USPL1

Expression for USPL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of USPL1 Gene:

USPL1

SOURCE GeneReport for Unigene cluster for USPL1 Gene:

Hs.533831
genes like me logo Genes that share expression patterns with USPL1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for USPL1 Gene

Orthologs for USPL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for USPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USPL1 34 35
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia USPL1 34 35
  • 84.7 (n)
cow
(Bos Taurus)
Mammalia USPL1 34 35
  • 82.03 (n)
mouse
(Mus musculus)
Mammalia Uspl1 34 16 35
  • 73.68 (n)
rat
(Rattus norvegicus)
Mammalia Uspl1 34
  • 72.92 (n)
oppossum
(Monodelphis domestica)
Mammalia USPL1 35
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USPL1 35
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves USPL1 34 35
  • 56.35 (n)
lizard
(Anolis carolinensis)
Reptilia USPL1 35
  • 36 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii uspl1 35
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToOne
Species where no ortholog for USPL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USPL1 Gene

ENSEMBL:
Gene Tree for USPL1 (if available)
TreeFam:
Gene Tree for USPL1 (if available)

Paralogs for USPL1 Gene

No data available for Paralogs for USPL1 Gene

Variants for USPL1 Gene

Sequence variations from dbSNP and Humsavar for USPL1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs10507389 -- 30,657,401(+) GTTGA(A/G)AAGGC intron-variant
rs1056489 -- 30,658,294(+) ACATC(C/T)AAGTC reference, synonymous-codon
rs111236247 -- 30,642,308(+) AGATC(-/T)TTTTT intron-variant
rs111247514 -- 30,619,326(+) ATTCT(A/G)TATAT intron-variant, upstream-variant-2KB
rs111302812 -- 30,617,852(+) ACGCC(A/T)CCGTC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for USPL1 Gene

Variant ID Type Subtype PubMed ID
nsv832574 CNV gain 17160897
nsv832573 CNV gain 17160897
nsv1122800 CNV deletion 24896259
esv3631679 CNV loss 21293372
esv3550265 CNV deletion 23714750
esv2747224 CNV deletion 23290073
esv2670401 CNV deletion 23128226
esv24978 CNV loss 19812545

Variation tolerance for USPL1 Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.36; 90.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USPL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USPL1 Gene

Disorders for USPL1 Gene

Relevant External Links for USPL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USPL1

No disorders were found for USPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USPL1 Gene

Publications for USPL1 Gene

  1. Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions. (PMID: 22878415) Schulz S. … Melchior F. (EMBO Rep. 2012) 2 3 4 64
  2. A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II. (PMID: 24413172) Hutten S. … Lamond A.I. (J. Cell. Sci. 2014) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Exploring the association between genetic variation in the SUMO isopeptidase gene USPL1 and breast cancer through integration of data from the population-based GENICA study and external genetic databases. (PMID: 23338788) Bermejo J.L. … Hamann U. (Int. J. Cancer 2013) 3 64
  5. Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. (PMID: 23891004) Stehling O. … Lill R. (Cell Metab. 2013) 3 64

Products for USPL1 Gene

Sources for USPL1 Gene

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