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Aliases for USPL1 Gene

Aliases for USPL1 Gene

  • Ubiquitin Specific Peptidase Like 1 2 3
  • Ubiquitin-Specific Peptidase-Like Protein 1 3 4
  • C13orf22 3 4
  • Chromosome 13 Open Reading Frame 22 2
  • SUMO-Specific Isopeptidase USPL1 3
  • Highly Charged Protein 3
  • EC 3.4.22.- 4
  • BA121O19.1 3
  • D13S106E 3
  • D13S106 4

External Ids for USPL1 Gene

Previous HGNC Symbols for USPL1 Gene

  • C13orf22

Previous GeneCards Identifiers for USPL1 Gene

  • GC13P030090
  • GC13P031191
  • GC13P012009

Summaries for USPL1 Gene

GeneCards Summary for USPL1 Gene

USPL1 (Ubiquitin Specific Peptidase Like 1) is a Protein Coding gene. GO annotations related to this gene include ubiquitin thiolesterase activity and SUMO binding.

UniProtKB/Swiss-Prot for USPL1 Gene

  • SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. May have non-catalytic functions in Cajal bodies organization and cell proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USPL1 Gene

Genomics for USPL1 Gene

Regulatory Elements for USPL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for USPL1 Gene

Start:
30,617,693 bp from pter
End:
30,660,770 bp from pter
Size:
43,078 bases
Orientation:
Plus strand

Genomic View for USPL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USPL1 Gene

Proteins for USPL1 Gene

  • Protein details for USPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5W0Q7-USPL1_HUMAN
    Recommended name:
    SUMO-specific isopeptidase USPL1
    Protein Accession:
    Q5W0Q7
    Secondary Accessions:
    • Q14109
    • Q6AI45
    • Q8IY30
    • Q8IYE8

    Protein attributes for USPL1 Gene

    Size:
    1092 amino acids
    Molecular mass:
    120440 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for USPL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USPL1 Gene

Proteomics data for USPL1 Gene at MOPED

Post-translational modifications for USPL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USPL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for USPL1 Gene

Domains for USPL1 Gene

Protein Domains for USPL1 Gene

Suggested Antigen Peptide Sequences for USPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5W0Q7

UniProtKB/Swiss-Prot:

USPL1_HUMAN :
  • Q5W0Q7
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USPL1: view

No data available for Gene Families for USPL1 Gene

Function for USPL1 Gene

Molecular function for USPL1 Gene

UniProtKB/Swiss-Prot Function: SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. May have non-catalytic functions in Cajal bodies organization and cell proliferation.

Enzyme Numbers (IUBMB) for USPL1 Gene

Gene Ontology (GO) - Molecular Function for USPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
GO:0032183 SUMO binding IDA 22878415
GO:0043130 NOT ubiquitin binding IDA 22878415
GO:0070140 SUMO-specific isopeptidase activity IDA 22878415
genes like me logo Genes that share ontologies with USPL1: view
genes like me logo Genes that share phenotypes with USPL1: view

Animal Model Products

CRISPR Products

miRNA for USPL1 Gene

miRTarBase miRNAs that target USPL1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USPL1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for USPL1 Gene

Localization for USPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USPL1 Gene

Nucleus, Cajal body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USPL1 Gene COMPARTMENTS Subcellular localization image for USPL1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for USPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0015030 Cajal body IDA 22878415
genes like me logo Genes that share ontologies with USPL1: view

Pathways for USPL1 Gene

SuperPathways for USPL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for USPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0008283 cell proliferation IMP 22878415
GO:0016926 protein desumoylation IDA 22878415
GO:0030576 Cajal body organization IMP 22878415
genes like me logo Genes that share ontologies with USPL1: view

No data available for Pathways by source for USPL1 Gene

Transcripts for USPL1 Gene

Unigene Clusters for USPL1 Gene

Ubiquitin specific peptidase like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USPL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USPL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^
SP1: - - - - - - - - -
SP2: -
SP3: -
SP4: - - - -
SP5: -
SP6:
SP7: - - - - - -
SP8:
SP9: - - - - - - -
SP10: - - - -

ExUns: 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for USPL1 Gene

GeneLoc Exon Structure for
USPL1
ECgene alternative splicing isoforms for
USPL1

Expression for USPL1 Gene

mRNA expression in normal human tissues for USPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for USPL1 Gene Hs.533831

genes like me logo Genes that share expressions with USPL1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for USPL1 Gene

Orthologs for USPL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for USPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USPL1 35
  • 99.15 (n)
  • 98.72 (a)
USPL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia USPL1 35
  • 82.03 (n)
  • 73.1 (a)
USPL1 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USPL1 35
  • 84.7 (n)
  • 74.39 (a)
USPL1 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uspl1 35
  • 73.68 (n)
  • 62.31 (a)
Uspl1 16
Uspl1 36
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia USPL1 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USPL1 36
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uspl1 35
  • 72.92 (n)
  • 61.36 (a)
chicken
(Gallus gallus)
Aves USPL1 35
  • 56.35 (n)
  • 41.46 (a)
USPL1 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USPL1 36
  • 36 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii uspl1 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for USPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USPL1 Gene

ENSEMBL:
Gene Tree for USPL1 (if available)
TreeFam:
Gene Tree for USPL1 (if available)

Paralogs for USPL1 Gene

No data available for Paralogs for USPL1 Gene

Variants for USPL1 Gene

Sequence variations from dbSNP and Humsavar for USPL1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs715887 -- 30,616,632(-) AGATT(A/G)TTAAT upstream-variant-2KB
rs717802 -- 30,616,158(+) CCTTT(A/G)TAAGT upstream-variant-2KB
rs751828 -- 30,617,837(+) TTCAC(A/C)TTCCC utr-variant-5-prime, upstream-variant-2KB
rs912390 -- 30,636,348(-) AAAAC(A/T)TACAT intron-variant
rs912391 -- 30,635,841(-) GTAAT(G/T)AATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USPL1 Gene

Variant ID Type Subtype PubMed ID
nsv832573 CNV Gain 17160897
esv2747224 CNV Deletion 23290073
esv2670401 CNV Deletion 23128226
esv24978 CNV Loss 19812545
nsv832574 CNV Gain 17160897

Relevant External Links for USPL1 Gene

HapMap Linkage Disequilibrium report
USPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USPL1 Gene

Disorders for USPL1 Gene

No disorders were found for USPL1 Gene.

No data available for UniProtKB/Swiss-Prot for USPL1 Gene

Publications for USPL1 Gene

  1. Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions. (PMID: 22878415) Schulz S. … Melchior F. (EMBO Rep. 2012) 2 3 4
  2. Exploring the association between genetic variation in the SUMO isopeptidase gene USPL1 and breast cancer through integration of data from the population-based GENICA study and external genetic databases. (PMID: 23338788) Bermejo J.L. … Hamann U. (Int. J. Cancer 2013) 3
  3. Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. (PMID: 23891004) Stehling O. … Lill R. (Cell Metab. 2013) 3
  4. A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II. (PMID: 24413172) Hutten S. … Lamond A.I. (J. Cell. Sci. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for USPL1 Gene

Sources for USPL1 Gene

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