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USPL1 Gene

protein-coding   GIFtS: 49
GCID: GC13P031191

Ubiquitin Specific Peptidase Like 1

(Previous name: chromosome 13 open reading frame 22)
(Previous symbol: C13orf22)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase Like 11 2     bA121O19.12
C13orf221 2 3     Highly Charged Protein2
Ubiquitin-Specific Peptidase-Like Protein 12 3     SUMO-Specific Isopeptidase USPL12
Chromosome 13 Open Reading Frame 221     D13S1063
D13S106E2     EC 3.4.22.-3

External Ids:    HGNC: 202941   Entrez Gene: 102082   Ensembl: ENSG000001329527   UniProtKB: Q5W0Q73   

Export aliases for USPL1 gene to outside databases

Previous GC identifers: GC13P030090 GC13P012009


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for USPL1 Gene:
USPL1 (ubiquitin specific peptidase like 1) is a protein-coding gene. GO annotations related to this gene include SUMO binding and ubiquitin thiolesterase activity.

UniProtKB/Swiss-Prot: USPL1_HUMAN, Q5W0Q7
Function: SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a
higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO
proteins to their mature forms. May have non-catalytic functions in Cajal bodies organization and cell
proliferation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USPL1 gene promoter:
         p53   SREBP-1c   POU3F2   SREBP-1b   Gfi-1   MEF-2A   PPAR-gamma1   SREBP-1a   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSPL1 promoter sequence
   Search Chromatin IP Primers for USPL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USPL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12-q14   Ensembl cytogenetic band:  13q12.3   HGNC cytogenetic band: 13q12-q14

USPL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USPL1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P031191:  view genomic region     (about GC identifiers)

Start:
31,191,830 bp from pter      End:
31,233,686 bp from pter
Size:
41,857 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: USPL1_HUMAN, Q5W0Q7 (See protein sequence)
Recommended Name: SUMO-specific isopeptidase USPL1  
Size: 1092 amino acids; 120440 Da
Secondary accessions: Q14109 Q6AI45 Q8IY30 Q8IYE8
Alternative splicing: 2 isoforms:  Q5W0Q7-1   Q5W0Q7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USPL1: NX_Q5W0Q7

Explore proteomics data for USPL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See USPL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005791.3  
    ENSEMBL proteins: 
     ENSP00000255304  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR028891 SUMO_USPL1
     IPR028889 UCH/PAN2
     IPR028890 Peptidase_C98

    Graphical View of Domain Structure for InterPro Entry Q5W0Q7

    ProtoNet protein and cluster: Q5W0Q7

    UniProtKB/Swiss-Prot: USPL1_HUMAN, Q5W0Q7
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 USP domain


    Find genes that share domains with USPL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: USPL1_HUMAN, Q5W0Q7
    Function: SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a
    higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO
    proteins to their mature forms. May have non-catalytic functions in Cajal bodies organization and cell
    proliferation

         Enzyme Number (IUBMB): EC 3.4.22.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity ----
    GO:0005515protein binding IPI--
    GO:0032183SUMO binding IDA--
    GO:0043130NOT ubiquitin binding IDA--
    GO:0070140SUMO-specific isopeptidase activity IDA--
         
    Find genes that share ontologies with USPL1           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for USPL1:
     Decreased Wnt reporter activit  Decreased cell number, increas  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 
     Increased gamma-H2AX phosphory  Increased number of mitotic ce  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Uspl1 (no phenotypes)

    Find genes that share phenotypes with USPL1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USPL1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USPL1
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    miRNA
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    miRTarBase miRNAs that target USPL1:
    hsa-mir-324-5p (MIRT043177), hsa-mir-320a (MIRT044741)

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    2 qRT-PCR Assays for microRNAs that regulate USPL1:
    hsa-miR-1206 hsa-miR-375
    SwitchGear 3'UTR luciferase reporter plasmidUSPL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat USPL1

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    Addgene plasmids for USPL1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USPL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    USPL1_HUMAN, Q5W0Q7: Nucleus, Cajal body
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0015030Cajal body IDA--

    Find genes that share ontologies with USPL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USPL1
    Interactions:

        Search GeneGlobe Interaction Network for USPL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for USPL1 (Q5W0Q71, 2, 3 ENSP000002553044) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO3P558541, 2EBI-2513899,EBI-474067 MINT-8406214 MINT-8406704 MINT-8406783 MINT-8406250 MINT-8403906 MINT-8406769 MINT-8406198 MINT-8404150 MINT-8406021 MINT-8406733 MINT-8406233 MINT-8404174 MINT-8406294
    SUMO1P631651, 2EBI-2513899,EBI-80140 MINT-8404163 MINT-8403978 MINT-8406010 MINT-8403747 MINT-8404137
    SUMO2P619561, 2, ENSP000004059654EBI-2513899,EBI-473220 MINT-8403775 STRING: ENSP00000405965
    CKBP122773, ENSP000002991984I2D: score=2 STRING: ENSP00000299198
    ELLP551993, ENSP000002628094I2D: score=2 STRING: ENSP00000262809
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0008283cell proliferation IMP--
    GO:0016926protein desumoylation IDA--
    GO:0030576Cajal body organization IMP--

    Find genes that share ontologies with USPL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USPL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USPL1 gene: 
    NM_005800.4  

    Unigene Cluster for USPL1:

    Ubiquitin specific peptidase like 1
    Hs.533831  [show with all ESTs]
    Unigene Representative Sequence: AL832776
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465952 ENST00000255304(uc001utb.3 uc001utc.2 uc001utd.2 uc001ute.1)

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate USPL1:
    hsa-miR-1206 hsa-miR-375
    SwitchGear 3'UTR luciferase reporter plasmidUSPL1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for USPL1
    Predesigned siRNA for gene silencing in human, mouse, rat USPL1
    Clone
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    OriGene clones in human, mouse for USPL1 (see all 10)
    OriGene ORF clones in mouse, rat for USPL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USPL1 (NM_005800)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USPL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USPL1
    Addgene plasmids for USPL1 
    Primer
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    OriGene qPCR primer pairs and template standards for USPL1
    OriGene qSTAR qPCR primer pairs in human, mouse for USPL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USPL1
      QuantiTect SYBR Green Assays in human, mouse, rat USPL1
      QuantiFast Probe-based Assays in human, mouse, rat USPL1

    Additional mRNA sequence: 

    AK057514.1 AK289826.1 AL832776.1 BC012594.1 BC036027.1 BC038103.2 CR627370.1 X59131.1 

    13 DOTS entries:

    DT.414948  DT.97816063  DT.100697429  DT.100778291  DT.95138020  DT.92068129  DT.100712914  DT.86849795 
    DT.120795193  DT.91747034  DT.120795194  DT.120795256  DT.100733811 

    Selected AceView cDNA sequences (see all 122):

    CR627370 AL529833 AL041997 BM021398 AW614152 BX390720 AL555440 BQ002506 
    BM720082 BC012594 D79366 T05588 AI223965 AA748739 CB130306 BG698085 
    AI091449 N59325 BM977282 BX332183 BM478607 BQ212795 BX492656 AI468024 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for USPL1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^
    SP1:                          -     -     -     -     -                                                                 -     -     -           -               
    SP2:                                                                                                                                            -               
    SP3:                                                                                                                                            -               
    SP4:                          -     -     -     -                                                                                                               
    SP5:                                            -                                                                                                               

    ExUns: 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:  -                                 
    SP2:  -                                 
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for USPL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USPL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATCTTTCT
    USPL1 Expression
    About this image


    USPL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    USPL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USPL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533831
        Custom PCR Arrays for USPL1
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    QuantiFast Probe-based Assays in human, mouse, rat USPL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USPL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for USPL1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uspl11 , 5 ubiquitin specific peptidase like 11, 5 73.68(n)1
    62.31(a)1
      5 (89.18 cM)5
    2319151  NM_001115149.11  NP_001108621.11 
     1491843505 
    chicken
    (Gallus gallus)
    Aves USPL11 ubiquitin specific peptidase like 1 56.35(n)
    41.46(a)
      395436  NM_001162393.2  NP_001155865.1 
    lizard
    (Anolis carolinensis)
    Reptilia USPL16
    ubiquitin specific peptidase like 1
    36(a)
    1 ↔ 1
    3(184517163-184537715)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377317662   -- 75(n)    137731766 
    zebrafish
    (Danio rerio)
    Actinopterygii uspl16
    ubiquitin specific peptidase like 1
    23(a)
    1 ↔ 1
    10(37683374-37700066) ENSDARG00000034825


    ENSEMBL Gene Tree for USPL1 (if available)
    TreeFam Gene Tree for USPL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USPL1 (see all 875)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs340740921,2
    C--12042693(+) AAAAA-/A/AA  
            
    GAAAG
    1 -- int11CSA 2
    rs1155214981,2
    F--31189835(+) GCAAGT/CAGCTT 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1379457881,2
    C--31189853(+) CCAGG-/TTTGGG 1 -- us2k10--------
    rs1915049971,2
    --31189938(+) TGAGAC/GAAAAA 1 -- us2k10--------
    rs771079271,2
    C,F--31189962(+) AATCAT/CACAGA 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1134228651,2
    C--31190090(+) CAAGCG/-GATGG 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1843365831,2
    --31190090(+) ACAAGA/CGATGG 1 -- us2k10--------
    rs1875288421,2
    --31190154(+) ATATGC/TAGAAA 1 -- us2k10--------
    rs1145622411,2
    F--31190173(+) TCAAAT/CATATA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1475393301,2
    --31190183(+) AGGAAC/TAACCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for USPL1 (31191830 - 31233686 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for USPL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747224CNV Deletion23290073
    esv2670401CNV Deletion23128226
    esv24978CNV Loss19812545
    nsv832573CNV Gain17160897
    nsv832574CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USPL1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with USPL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions. (PubMed id 22878415)1, 2, 3 Schulz S.... Melchior F. (EMBO Rep. 2012)
    2. Exploring the association between genetic variation in the SUMO isopeptidase gene USPL1 and breast cancer through integration of data from the population-based GENICA study and external genetic databases. (PubMed id 23338788)1 Bermejo J.L....Hamann U. (Int. J. Cancer 2013)
    3. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)
    4. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    5. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (Nature 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10208 HGNC: 20294 AceView: C13orf22 Ensembl:ENSG00000132952 euGenes: HUgn10208
    ECgene: USPL1 H-InvDB: USPL1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USPL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USPL1 gene:
    Search GeneIP for patents involving USPL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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