Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP9X Gene

protein-coding   GIFtS: 62
GCID: GC0XP040944

ubiquitin specific peptidase 9, X-linked

(Previous names: ubiquitin specific protease 9, X chromosome (fat facets-like...)
 Explore 7 diseases affiliated with
USP9X via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for USP9X    

Aliases
for USP9X gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ubiquitin Specific Peptidase 9, X-Linked1 2     HFAM1
DFFRX1 2 3 5     Ubiquitin Specific Peptidase 9, X-Linked (Fat Facets-Like, Drosophila)1
FAF1 2     Ubiquitin Specific Protease 9, X-Linked (Fat Facets-Like, Drosophila)1
Ubiquitin Specific Protease 9, X Chromosome (Fat Facets-Like Drosophila)1 2     Drosophila Fat Facets Related, X-Linked2
Deubiquitinating Enzyme FAF-X2 3     Fat Facets Protein Related, X-Linked2
Fat Facets In Mammals2 3     Probable Ubiquitin Carboxyl-Terminal Hydrolase FAF-X2
Fat Facets Protein-Related, X-Linked2 3     Ubiquitin Thiolesterase FAF-X2
Ubiquitin Thioesterase FAF-X2 3     Ubiquitin-Specific Processing Protease FAF-X2
Ubiquitin-Specific Protease 9, X Chromosome2 3     EC 3.4.19.123
Ubiquitin-Specific-Processing Protease FAF-X2 3     USP93
FAM2 3     EC 3.1.2.158

External Ids:    HGNC: 126321   Entrez Gene: 82392   Ensembl: ENSG000001244867   OMIM: 3000725   UniProtKB: Q930083   

Export aliases for USP9X gene to outside databases

Previous GC identifers: GC0XP039009 GC0XP039231 GC0XP039827 GC0XP040013 GC0XP040739 GC0XP040829 GC0XP038676


Summaries
for USP9X gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for USP9X:
This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific
proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have
been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have
been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: USP9X_HUMAN, Q93008
Function: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May
therefore play an important role regulatory role at the level of protein turnover by preventing degradation of
proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates
chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic
centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically
deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33

Gene Wiki entry for USP9X


Genomic Views
for USP9X gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_079573.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP9X gene promoter:
         MEF-2   Egr-1   c-Ets-1   Meis-1b   Egr-4   RORalpha1   Ik-2   Meis-1a   aMEF-2   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for USP9X

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP9X


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.4   Ensembl cytogenetic band:  Xp11.4   HGNC cytogenetic band: Xp11.4

USP9X Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP9X gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP040944:  view genomic region     (about GC identifiers)

Start:
 40,944,888 bp from pter      End:
 41,095,832 bp from pter
Size:
 150,945 bases      Orientation:
 plus strand

Proteins
for USP9X gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: USP9X_HUMAN, Q93008 (See protein sequence)
Recommended Name: Probable ubiquitin carboxyl-terminal hydrolase FAF-X  
Size: 2570 amino acids; 292280 Da
Subunit: Interacts with SMAD4, MARK4, NUAK1 and BIRC5/survivin
Subcellular location: Cytoplasm
Miscellaneous: Escapes X-inactivation
Sequence caution: Sequence=CAD13527.2; Type=Erroneous gene model prediction; Sequence=CAD18900.2; Type=Erroneous gene
model prediction;
Secondary accessions: O75550 Q8WWT3 Q8WX12
Alternative splicing: 2 isoforms:  Q93008-3   Q93008-1   

Explore the universe of human proteins at neXtProt for USP9X: NX_Q93008

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q93008

    • 4/16 DME Specific Peptides for USP9X (Q93008) (see all 16)
     INKDFFE  PFGQCYE  HYQKRAYQ  IQQLYMIP 

    USP9X Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001034679.2  NP_001034680.2  

    ENSEMBL proteins: 
     ENSP00000367558   ENSP00000316357   ENSP00000420609   ENSP00000420570  
    Reactome Protein details: Q93008
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for USP9X
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for USP9X 
    GenScript Custom Purified and Recombinant Proteins Services for USP9X
    Novus Biologicals USP9X Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for USP9X

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19135894
    GO:0005829cytosol TAS--
    GO:0045177apical part of cell IEA--


    USP9X for ontologies           About GeneDecksing



    USP9X Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for USP9X 
    OriGene Antibodies (see all 4): USP9X
    OriGene Custom Antibody Services for USP9X 
    GenScript Custom Superior Antibodies Services for USP9X
    Novus Biologicals USP9X Antibodies
    Search for Antibodies for USP9X at Abcam  
    Uscn Antibodies for USP9X
    ThermoFisher Antibody for USP9X

    Assay Products for USP9X: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP9X
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for USP9X

    Protein Domains /
    Families
    for USP9X gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    USP9X for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS

    Graphical View of Domain Structure for InterPro Entry Q93008

    ProtoNet protein and cluster: Q93008

    1 Blocks protein family: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: USP9X_HUMAN, Q93008
    Similarity: Belongs to the peptidase C19 family


    Function
    for USP9X gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: USP9X_HUMAN, Q93008
    Function: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May
    therefore play an important role regulatory role at the level of protein turnover by preventing degradation of
    proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates
    chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic
    centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically
    deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the
    C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP9X:
    ubiquitin specific protease 9,X chromosome,Drosophila developmental gene fat facets related on the X,Dres14 mouse
    homolog,ubiquitously expressed at low levels in embryo,escaping inactivation,widely expressed,deubiquitin enzyme
    family

    Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): USP9X
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP9X
    8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate USP9X (see all 87):
    hsa-miR-100* hsa-miR-640 hsa-miR-15a hsa-miR-199a-3p hsa-miR-134 hsa-miR-200a hsa-miR-138-2* hsa-miR-1244
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP9X (see all 7)
    OriGene shRNA RFP: USP9X
    OriGene siRNA: USP9X
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP9X

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for USP9X

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP9X (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP9X (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): USP9X (NM_001039590)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP9X
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat USP9X 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for USP9X
    Search LifeMap BioReagents cell lines for USP9X

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP9X

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity TAS9827704
    GO:0004221ubiquitin thiolesterase activity TAS--
    GO:0005515protein binding IPI19135894
    GO:0008234cysteine-type peptidase activity TAS8922996
    GO:0070410co-SMAD binding IPI19135894


    USP9X for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for USP9X:
     Decreased Wnt reporter activit  Increased Salmonella enterica   Increased Salmonella enterica   Increased cell death in HCT116 
     Synthetic lethal with Ras 

    Animal Models:
         8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Usp9x):
     cardiovascular system  embryogenesis  growth/size  integument  mortality/aging 
     nervous system  normal  tumorigenesis 

    USP9X for phenotypes           About GeneDecksing


    Pathways & Interactions
    for USP9X gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    		Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer1.00
    		Downregulation of SMAD2/3:SMAD4 transcriptional activity0.56
    		Signaling by TGF-beta Receptor Complex0.61
    2Generic Transcription Pathway
    		Generic Transcription Pathway1.00
    		Gene Expression0.46
    3Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00
    4Ubiquitin-Proteasome Dependent Proteolysis
    		Ubiquitin-Proteasome Dependent Proteolysis1.00
    5Protein Stability
    		Protein Stability1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP9X
        Ubiquitin-Proteasome Dependent Proteolysis

    2 Cell Signaling Technology (CST) Pathways for USP9X
        Cytoskeletal Signaling
    Protein Stability

    5/6        Reactome Pathways for USP9X (see all 6)
        Signaling by TGF-beta Receptor Complex
    Downregulation of SMAD2/3:SMAD4 transcriptional activity
    Generic Transcription Pathway
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Signal Transduction



    USP9X for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for USP9X

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/160 Interacting proteins for USP9X (Q930081, 2, 3 ENSP000003163574) via UniProtKB, MINT, STRING, and/or I2D (see all 160)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB2Q006532, 3MINT-47897 MINT-48775 MINT-48630 I2D: score=2 
    RELBQ012012, 3, ENSP000002214524MINT-49035 I2D: score=2 STRING: ENSP00000221452
    SMAD4Q134851, 3, ENSP000003415514EBI-1058656,EBI-347263 I2D: score=2 STRING: ENSP00000341551
    MYCBP2O755922, 3, ENSP000003498924MINT-8395092 I2D: score=1 STRING: ENSP00000349892
    MAP3K1Q132332, 3MINT-48359 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS--
    GO:0006351transcription, DNA-dependent TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0007059chromosome segregation IEA--


    USP9X for ontologies           About GeneDecksing



    Drugs & Compounds
    for USP9X gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP9X

    1 HMDB Compound for USP9X    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about USP9X 

    Transcripts
    for USP9X gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for USP9X gene (4 alternative transcripts): 
    NM_001039590.2  NM_001039591.2  NM_004652.3  NM_021906.2  

    Unigene Cluster for USP9X:

    Ubiquitin specific peptidase 9, X-linked
    Hs.77578  [show with all ESTs]
    Unigene Representative Sequence: NM_001039590
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378308 ENST00000324545(uc004dfb.3 uc004dfc.3) ENST00000453805
    ENST00000467173 ENST00000465386 ENST00000463829 ENST00000462850 ENST00000487625
    ENST00000485180

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): USP9X
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP9X
    8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate USP9X (see all 87):
    hsa-miR-100* hsa-miR-640 hsa-miR-15a hsa-miR-199a-3p hsa-miR-134 hsa-miR-200a hsa-miR-138-2* hsa-miR-1244
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP9X (see all 7)
    OriGene shRNA RFP: USP9X
    OriGene siRNA: USP9X
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP9X
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP9X (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP9X (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): USP9X (NM_001039590)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP9X
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat USP9X 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP9X
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP9X
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP9X
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP9X

    Additional cDNA sequence: 

    AB209666.1 AF070645.1 AJ012078.1 AK294828.1 BC014792.1 BC046205.1 BC054861.1 BC063645.1 
    X98296.1 

    20 DOTS entries:

    DT.100735421  DT.100642917  DT.95123335  DT.318983  DT.97768434  DT.99931034  DT.102834490  DT.95205087 
    DT.95123237  DT.97776989  DT.121297833  DT.92435812  DT.100742016  DT.102834493  DT.91891417  DT.95123283 
    DT.95123307  DT.100809631  DT.101963536  DT.437898 

    24/454 AceView cDNA sequences (see all 454):

    AU132252 AA909608 AW006637 AW450145 AI149296 BU619738 BG696781 CB121069 
    AU119456 CB270270 AI989291 BM785865 AL551880 R79791 BM852392 AU125746 
    CR606277 H43881 AU122610 BE464095 AI859885 AA954273 CB240829 BM750998 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for USP9X (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b · 26c ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37a · 37b ^ 38 ^
    SP1:                                                  -                                                                                               -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 39a · 39b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for USP9X

    Expression
    for USP9X gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP9X expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    USP9X expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    HSF-1 (UC01) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See USP9X Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP9X

    SOURCE GeneReport for Unigene cluster: Hs.77578

    UniProtKB/Swiss-Prot: USP9X_HUMAN, Q93008
    Tissue specificity: Widely expressed in embryonic and adult tissues

        SABiosciences Custom PCR Arrays for USP9X
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP9X
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP9X
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP9X
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP9X
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP9X

    Orthologs
    for USP9X gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for USP9X gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Usp9x1 , 5 ubiquitin specific peptidase 9, X chromosome1, 5 92.85(n)1
    98.47(a)1    		   X (7.95 cM)5
    222841  NM_009481.21  NP_033507.21 
     130714985 
    chicken
    (Gallus gallus)    		 Aves USP9X1 ubiquitin specific peptidase 9, X-linked 85.97(n)
    95.49(a)    		   418569  XM_416773.3  XP_416773.2 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 95(a)
    		 1 → many
    		 3(133970926-134041276)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.44902 Xenopus laevis transcribed sequence with moderate similarity more 87.46(n)    BJ085423.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii usp91 ubiquitin specific peptidase 9 76.27(n)
    90.27(a)    		   568683  NM_001077449.1  NP_001070917.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta faf1 , 3 protein deubiquitination ubiquitin-specific
    protease3
    fat facets1    		 47(a)3
    54.01(n)1
    51.5(a)1    		   100D23
    437491  NM_079873.41  NP_524612.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea F37B12.43 ubiquitin carboxyl-terminal hydrolase 30(a)   II(9042685-9047401)   --


    ENSEMBL Gene Tree for USP9X (if available)
    TreeFam Gene Tree for USP9X (if available) 

    Paralogs
    for USP9X gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP9X gene
    USP242  USP182  USP412  USP482  USP402  USP72  USP472  USP9Y2  
    USP342  
    2 SIMAP similar genes for USP9X using alignment to 6 protein entries:     USP9X_HUMAN (see all proteins):
    USP9Y    USP24

    USP9X for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for USP9X (see all 8)
    PGOHUM00000233766 PGOHUM00000233767 PGOHUM00000233838 PGOHUM00000233872 PGOHUM00000233975


    Genomic Variants
    for USP9X gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1707 NCBI SNPs in USP9X are shown (see all 1707)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1893797991,2
    		--40943156(+) CATTAG/TTTTGG 2 -- us2k10--------
    rs1812622211,2
    		--40943164(+) TGGTTC/GCATTT 2 -- us2k10--------
    rs1420661731,2
    		--40943397(+) CCCATG/TAATTT 2 -- us2k10--------
    rs1846841641,2
    		--40943501(+) CCGGGG/TCCTAA 2 -- us2k10--------
    rs1890013031,2
    		--40943502(+) CGGGTC/TCTAAC 2 -- us2k10--------
    rs1819971021,2
    		--40943692(+) TGAGGA/TCGCCT 2 -- us2k10--------
    rs1870891101,2
    		--40943729(+) TGATCA/GTGTGA 2 -- us2k10--------
    rs1911013101,2
    		--40943762(+) CTCGCC/GGGGTG 2 -- us2k10--------
    rs1807242261,2
    		--40943791(+) CCCACA/GCCCCC 2 -- us2k10--------
    rs1865737781,2
    		--40944267(+) CCGCTC/TCTGAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for USP9X (40944888 - 41095832 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for USP9X
         4 CNVs: 7787 52993 52992 52991
    Human Gene Mutation Database (HGMD): USP9X

    Locus Specific Mutation Databases (LSDB): USP9X

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP9X
    DNA2.0 Custom Variant and Variant Library Synthesis for USP9X

    Disorders / Diseases
    for USP9X gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    USP9X for disorders           About GeneDecksing

    OMIM gene information: 300072    OMIM disorders: --

    7 diseases for USP9X:    About MalaCards
    x inactivation    turner syndrome    dermatomycosis    noma
    pancreatitis    malaria    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: USP9X (4 documents)

    Export disorders for USP9X gene to outside databases

    Publications
    for USP9X gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP9X gene, integrated from 9 sources (see all 68):
    (articles sorted by number of sources associating them with USP9X)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2. (PubMed id 8922996)1, 2, 3 Jones M.H.... Affara N.A. (1996)
    2. FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. (PubMed id 19135894)1, 2 Dupont S.... Piccolo S. (2009)
    3. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. (PubMed id 18254724)1, 2 Al-Hakim A.K....Alessi D.R. (2008)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    7. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    8. Chromosome alignment and segregation regulated by ubiquitination of survivin. (PubMed id 16322459)1, 2 Vong Q.P....Zheng Y. (2005)
    9. The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X. (PubMed id 18410486)1, 9 Nathan J.A....Lehner P.J. (2008)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for USP9X gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing USP9X gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8239 HGNC: 12632 AceView: USP9X Ensembl:ENSG00000124486 euGenes: HUgn8239
    ECgene: USP9X H-InvDB: USP9X

    Other Databases showing USP9X gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing USP9X gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP9X Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for USP9X gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for USP9X gene:
    Search GeneIP for patents involving USP9X

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for USP9X gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for USP9X (USP9x)  
     OriGene Antibodies for USP9X   OriGene shRNA RFP for USP9X  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP9X   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP9X  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for USP9X   OriGene 3'-UTR Clone for USP9X  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP9X   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP9X  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for USP9X   OriGene Custom Protein Services for USP9X  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP9X
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP9X
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP9X
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP9X
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP9X
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP9X
     GenScript Custom Purified and Recombinant Proteins Services for USP9X GenScript cDNA clones with any tag delivered in your preferred vector for USP9X
     GenScript Custom Assay Services for USP9X GenScript Custom Superior Antibodies Services for USP9X
     GenScript Custom overexpressing Cell Line Services for USP9X CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for USP9X 

     Regulatory tfbs in USP9X promoter
     Search Chromatin IP Primers for USP9X
     RT2 qPCR Primer Assay in human, mouse, rat USP9X
     GNC Network for USP9X
     SABiosciences PCR Arrays including human, mouse, rat USP9X
     Search Tocris compounds for USP9X
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     USP9X antibodies
     USP9X proteins
     Search for Antibodies for USP9X at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for USP9X
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     USP9X Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for USP9X
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP9X
     Browse SwitchGear 3'UTR luciferase reporter plasmids for USP9X
     Browse SwitchGear Promoter luciferase reporter plasmids for USP9X
     ThermoFisher Antibody for USP9X
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat USP9X
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      USP9X gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4