USP8 Gene
protein-coding GIFtS: 67
GCID: GC15P050716
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|
ubiquitin specific peptidase 8(Previous name: ubiquitin specific protease 8 )
| |
Aliases
for USP8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 81 2 | | Ubiquitin Thioesterase 82 3 | | UBPY1 2 3 | | Ubiquitin-Specific-Processing Protease 82 3 | | HumORF81 2 | | HUBPy1 | | Ubiquitin Specific Protease 81 2 | | Ubiquitin Carboxyl-Terminal Hydrolase 82 | | KIAA00551 3 | | Ubiquitin Thiolesterase 82 | | Deubiquitinating Enzyme 82 3 | | EC 3.4.19.123 | | Ubiquitin Isopeptidase Y2 3 | | EC 3.1.2.158 |
Export aliases for USP8 gene to outside databasesPrevious GC identifers: GC15P046273 GC15P043762 GC15P048295 GC15P048432 GC15P048503 GC15P027548 |
Summaries
for USP8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UBP8_HUMAN, P40818Function: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory roleat the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitinchains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phasein response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complexcontaining RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitindynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level ofprotein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. DeubiquitinatesEPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradationand downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complexand microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1
Gene Wiki entry for USP8
|
Genomic Views
for USP8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP8 gene promoter:
C/EBPbeta Elk-1 AML1a ATF-2 p300 Lmo2 C/EBPalpha CREB FAC1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q21.2 Ensembl cytogenetic band: 15q21.2 HGNC cytogenetic band: 15q21.1USP8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P050716: view genomic region
(about GC identifiers)
Start:
|
50,716,577 bp from pter |
End:
|
50,793,280 bp from pter |
Size:
|
76,704 bases |
Orientation:
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plus strand |
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Proteins
for USP8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP8_HUMAN, P40818 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 8 Size: 1118 amino acids; 127523 Da
Subunit: Forms a ternary complex with RNF128 and OTUB1. Interacts (via C-terminal UCH catalytic domain) with OTUB1isoform 1. Interacts with STAM2 (via SH3 domain). Interacts with DNAJB3, EGFR, EPS15, RASGRF1, RNF41, YWHAE, YWHAG andYWHAZ (By similarity). Interacts with NBR1, RASGRF1, RNF41 and IST1. Associates with the ESCRT-0 complex and withmicrotubules (By similarity). Interacts with BIRC6/bruce and KIF23/MKLP1
Subcellular location: Cytoplasm. Nucleus (By similarity). Endosome membrane; Peripheral membrane protein. Cellmembrane; Peripheral membrane protein
Sequence caution: Sequence=AAH38801.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=AAH51345.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
5 PDB 3D structures from  and Proteopedia  for USP8:1WHB (3D)
2A9U (3D)
2GFO (3D)
2GWF (3D)
3N3K (3D)
Secondary accessions: Q2TB31 Q7Z3U2 Q86VA0 Q8IWI7Explore the universe of human proteins at neXtProt for USP8: NX_P40818
Post-translational modifications:
Phosphorylation of Ser-718 is essential for interaction with YWHAE and for cytosol localization (By similarity).Undergoes dephosphorylation at Ser-718 in the M phase (By similarity). Tyrosine-phosphorylated in its N-terminal halfin an EGFR-dependent manner (By similarity)1
Ubiquitinated. Inactive form is mostly monoubiquitinated, but polyubiquitination happens too. Ubiquitination isincreased in EGF-stimulated cells. Ubiquitination of active form is undetectable, suggesting a possibility that USP8deubiquitinates itself, thereby regulating its own function (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P40818
3 DME Specific Peptides for USP8 (P40818)
USP8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001122082.1 NP_001122083.1 NP_005145.3
ENSEMBL proteins: ENSP00000453206 ENSP00000302239 ENSP00000379721 ENSP00000412682 ENSP00000454003 ENSP00000452950 ENSP00000453427 ENSP00000457345 ENSP00000454059 ENSP00000453320 ENSP00000453460 ENSP00000405537 Reactome Protein details: P40818
Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
USP8 for ontologies About GeneDecksing
USP8 Antibody Products:
Assay Products for USP8: |
Protein
Domains /
Families
for USP8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP8 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P40818ProtoNet protein and cluster: P40818 3 Blocks protein families: IPB001394 Ubiquitin thiolesterase IPB001448 Small acid-soluble spore protein IPB001763 Rhodanese-like
UniProtKB/Swiss-Prot: UBP8_HUMAN, P40818Domain: The MIT domain is required for endosomal localization, CHMP1B-binding, maintenance of ESCRT-0 stability andEGFR degradationDomain: The rhodanese domain is sufficent for RNF41-binding (By similarity)Similarity: Belongs to the peptidase C19 familySimilarity: Contains 1 MIT domainSimilarity: Contains 1 rhodanese domain |
Function
for USP8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBP8_HUMAN, P40818Function: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory roleat the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitinchains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phasein response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complexcontaining RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitindynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level ofprotein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. DeubiquitinatesEPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradationand downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complexand microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)Induction: Upon growth stimulation in starved human fibroblasts. Decreases in response to growth arrest induced bycell-cell contact Genatlas biochemistry entry for USP8:ubiquitin specific protease 8,similar to the tre oncogene,with homology to ubiquitin carboxy-terminalhydrolase,deubiquitin enzyme family
Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP8 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP8 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: USP8 (NM_004420) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP8 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
USP8 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for USP8:
Animal Models:
Mouse knock-out Usp8tm1.2Kpk for USP8
7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Usp8):
USP8 for phenotypes About GeneDecksing
|
Pathways & Interactions
for USP8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Tyrosine Kinases / Adaptors | | | 2 | Protein Stability | | | 3 | Ubiquitin-Proteasome Dependent Proteolysis | | | 4 | Internalization of ErbB1 | | | 5 | Endocytosis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP8
2 
Cell Signaling Technology (CST) Pathways for USP8
2  BioSystems Pathways for USP8
3 
Reactome Pathways for USP8
1 
Kegg Pathway (Kegg details for USP8):
USP8 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for USP8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/52 Interacting proteins for USP8 (P408181, 2, 3 ENSP000003022394) via UniProtKB, MINT, STRING, and/or I2D (see all 52)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CHMP1A | Q9HD421, 2, 3, ENSP000002534754 | EBI-1050865,EBI-1057156 MINT-6946783 I2D:
score=3 STRING: ENSP00000253475 | | CHMP1B | Q7LBR11, 2, 3 | EBI-1050865,EBI-2118090 MINT-6946799 I2D:
score=3 | | NBR1 | Q145962, 3, ENSP000003434794 | MINT-7034470 MINT-7034233 MINT-7034452 I2D:
score=1 STRING: ENSP00000343479 | | YWHAG | P619812, 3, ENSP000003063304 | MINT-50884 I2D:
score=4 STRING: ENSP00000306330 | | YWHAB | P319462, 3, ENSP000003001614 | MINT-50951 I2D:
score=3 STRING: ENSP00000300161 |
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
USP8 for ontologies About GeneDecksing
|
Drugs & Compounds
for USP8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
USP8 for compounds About GeneDecksing
 Browse Tocris compounds for USP8
1 HMDB Compound for USP8 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Water | Dihydrogen oxide (see all 2) | 7732-18-5 | -- |
1 Novoseek chemical compound relationship for USP8 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
26.7 |
1 |
14646586 (1) |
Search CenterWatch for drugs/clinical trials and news about USP8 / UBP8
|
Transcripts
for USP8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP8 gene (3 alternative transcripts): NM_001128610.1 NM_001128611.1 NM_005154.3 Unigene Cluster for USP8: Ubiquitin specific peptidase 8 Hs.443731 [show with all ESTs]Unigene Representative Sequence: NM_00112861118/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000560297 ENST00000560954 ENST00000307179(uc001zyk.1 uc010bev.1)
ENST00000396444(uc001zyl.4 uc001zyn.4 uc010ufh.2 uc001zyp.4)
ENST00000425032 ENST00000558892 ENST00000560885 ENST00000559329 ENST00000560730
ENST00000560982 ENST00000561211 ENST00000558091 ENST00000559242 ENST00000561330
ENST00000560527 ENST00000561206 ENST00000419830 ENST00000560379
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP8 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP8 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: USP8 (NM_004420) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP8 |
Additional cDNA sequence: AK090830.1 AK292400.1 AK296480.1 AK300590.1 BC015545.1 BC026954.1 BC038801.1 BC051345.1 BC062694.1 BC092443.1 BC110590.2 BX537420.1 D29956.1 17 DOTS entries: DT.101983565 DT.117668 DT.444526 DT.121045161 DT.95276438 DT.95276444 DT.121045139 DT.102841822 DT.95290024 DT.92437210 DT.100795148 DT.121045147 DT.121045187 DT.121045207 DT.121310784 DT.95276443 DT.95276440 24/277 AceView cDNA sequences (see all 277): AI812012 BM723958 BG562497 CN481560 BF435143 AI655860 AI479489 BU789750 AA236062 AI973154 BQ425745 BQ424717 AW503369 AI222503 AA773709 AI952505 BI256314 BC051345 AW299898 BP379003 BQ943006 AA149437 AI478120 BX474570
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for USP8 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21a | · | 21b | ^ | 22a | · | 22b | · | 22c |
|---|
|
| SP1: | - | | | | | | | | | | |
| SP2: | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | |
| SP4: | - | | | | | | | | | | |
| SP5: | | | | | | | | | | |
ECgene alternative splicing isoforms for USP8
|
Expression
for USP8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATATAGCCT
About this image
See USP8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP8
SOURCE GeneReport for Unigene cluster: Hs.443731
SABiosciences Custom PCR Arrays for USP8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP8 |
Orthologs
for USP8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for USP8 gene from 5/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
USP81 |
ubiquitin specific peptidase 8 |
75.98(n)
75.14(a) |
|
415451 XM_413830.3 XP_413830.3 |
lizard
(Anolis carolinensis) |
Reptilia |
USP86 |
-- |
70(a) |
1 ↔ 1 |
GL343747.1(72194-90819) |
African clawed frog
(Xenopus laevis) |
Amphibia |
usp8-prov2 |
ubiquitin specific protease 8 |
75.61(n) |
|
BC043910.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
usp81 |
ubiquitin specific peptidase 8 |
59.63(n)
61.74(a) |
|
565434 XM_688719.5 XP_693811.5 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG57983
Ubpy1 |
protein deubiquitination ubiquitin-specific
protease3
UBPY ortholog1 |
44(a)3
45.29(n)1
36.93(a)1 |
|
93C13
425091 NM_142691.21 NP_650948.21 |
ENSEMBL Gene Tree for USP8 (if available)
TreeFam Gene Tree for USP8 (if available) |
Paralogs
for USP8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP8 gene
- USP17L132 USP17L282 USP17L242 USP17L302 USP17L122 USP17L172 USP17L262 USP17L232
- USP17L182 USP422 USP17L252 USP17L152 USP17L212 USP17L202 USP17L192 USP17L102
- USP22 USP362 USP17L272 USP212 USP17L222 USP17L52 USP17L22 USP17L292
- USP17L112 USP502
7 SIMAP similar genes for USP8 using alignment to 10 protein entries: UBP8_HUMAN (see all proteins):USP15 USP11 USP2 USP50 USP3 USP10
DKFZp761E10121
USP8 for paralogs About GeneDecksing
5/8 Pseudogenes.org Pseudogenes for USP8 (see all 8)
PGOHUM00000240382 PGOHUM00000262007 PGOHUM00000261979 PGOHUM00000261983 PGOHUM00000261975
|
Genomic Variants
for USP8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP8 (50716577 - 50793280 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for USP8
2 CNVs: 53349 29644
1 Indel: 25526 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP8 |
|
Disorders
/ Diseases
for USP8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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USP8 for disorders About GeneDecksing
OMIM gene information: 603158
OMIM disorders: --
5  diseases for USP8: About MalaCardsatrial fibrillation psoriatic arthritis arthritis psoriasis
malaria
Human Genome Epidemiology (HuGE) Navigator: USP8 (1 document)
Export disorders for USP8 gene to outside databases
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Publications
for USP8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for USP8 gene, integrated from 9 sources (see all 62):
(articles sorted by number of sources associating them with USP8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8). (PubMed id 17035239)1, 2, 9 Avvakumov G.V.... Dhe-Paganon S. (2006)
- Interactions with LC3 and polyubiquitin chains link n br1 to autophagic protein turnover. (PubMed id 19427866)1, 2 Waters S....Gautel M. (2009)
- Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. (PubMed id 18329369)1, 2 Pohl C. and Jentsch S. (2008)
- The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation. (PubMed id 17711858)1, 2 Row P.E....Urbe S. (2007)
- The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation. (PubMed id 16520378)1, 2 Row P.E....Urbe S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- UBPY: a growth-regulated human ubiquitin isopeptidase. (PubMed id 9628861)1, 2 Naviglio S.... Draetta G.F. (1998)
- An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme. (PubMed id 9582025)1, 3 Janssen J.W.G.... Schulz A.S. (1998)
- Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N....Tabata S. (1994)
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External Searches for USP8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing USP8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing USP8 gene
(According to HUGE)
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Specialized Databases showing USP8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for USP8 gene:
Search GeneIP for patents involving USP8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for USP8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for USP8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP8 | | | OriGene Protein Over-expression Lysate for USP8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for USP8 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for USP8 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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