USP7 Gene
protein-coding GIFtS : 70 GCID: GC16 M008985
ubiquitin specific peptidase 7 (herpes virus-associated) ubiquitin specific protease 7 (herpes virus-associated)... HAUSP )
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Aliasesfor USP7 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) 1 2 Ubiquitin-Specific-Processing Protease 72 3 HAUSP1 2 3 5 TEF12 Ubiquitin Specific Protease 7 (Herpes Virus-Associated)1 2 Herpes Virus-Associated Ubiquitin-Specific Protease2 Deubiquitinating Enzyme 72 3 Ubiquitin Carboxyl-Terminal Hydrolase 72 Herpesvirus-Associated Ubiquitin-Specific Protease2 3 EC 3.4.19.123 Ubiquitin Thioesterase 72 3 EC 3.1.2.158
Export aliases for USP7 gene to outside databases Previous GC identifers: GC16M008792 GC16M009087 GC16M008953 GC16M008954 GC16M008894 GC16M008907
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Summariesfor USP7 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: UBP7_HUMAN, Q93009 Function : Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN andDAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1. Exhibits a preference towards 'Lys-48'-linked Ubiquitin chains summary
for USP7 : Ubiquitin-specific-processing protease 7 (USP7) is a protease that removes ubiquitin modifications fromproteins; it is also known as a deubiquitinating enzyme (DUB). It stabilizes p53 by deubiquitinating it andprotecting it from proteasomal degradation. Gene Wiki entry for USP7
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Genomic Viewsfor USP7 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000016.9 NC_018927.1 NT_010393.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the USP7 gene promoter:Max1 E47 Arnt AREB6 Max PPAR-gamma1 PPAR-gamma2 NF-kappaB1 c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for USP7 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.2 HGNC cytogenetic band: 16p13.3 USP7 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16M008985: view genomic region
(about GC identifiers )
Start: 8,985,951 bp from pter End:
9,058,371 bp from pter
Size: 72,421 bases Orientation:
minus strand
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Proteinsfor USP7 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: UBP7_HUMAN, Q93009 See
protein sequence )Recommended Name: Size : 1102 amino acids; 128302 DaSubunit : Monomer. Homodimer. Part of a complex with DAXX, MDM2, RASSF1 and USP7. Part of a complex with DAXX, MDM2 andUSP7. Interacts with MDM2; the interaction is independent of p53/TP53. Interacts with DAXX; the interaction is direct and independent of MDM2 and p53/TP53. Interacts with FOXO4; the interaction is enhanced in presence of hydrogen peroxide and occurs independently of p53/TP53. Interacts with p53/TP53; the interaction is enhanced in response to DNA damage; the interaction is impaired by TSPYL5. Interacts with PTEN; the interaction is direct. Interacts with UBXN6. Interacts with ATXN1 and the strength of interaction is influenced by the length of the poly-Gln region in ATXN1. A weaker interaction seen with mutants having longer poly-Gln regions. Interacts with KIAA1530/UVSSA. Isoform 1 and isoform 2 interact with herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110. Interacts with Epstein-Barr virus EBNA1. EBNA1 shows a 10-fold higher affinity than p53/TP53 and can compete with it for USP7 binding. Binding to ICP0/VMW110 may modulate the substrate specificity or activity of USP7 to stabilize viral proteins. Interacts with MEX3C and antagonizes its ability to degrade mRNA. Interacts with DNMT1 and UHRF1
Subcellular location : Nucleus. Cytoplasm. Nucleus, PML body. Note=Present in a minority of ND10 nuclear bodies.Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies
6/16 PDB 3D structures from (see all 16 ):1NB8 (3D) 1NBF (3D) 1YY6 (3D) 1YZE (3D) 2F1W (3D) 2F1X (3D) Secondary accessions : A6NMY8Alternative splicing : 2 isoforms : Q93009-1 Q93009-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for USP7: NX_Q93009 Post-translational modifications:
Isoform 1: Phosphorylated. Isoform 1 is phosphorylated at positions Ser-18 and Ser-963. Isoform 2: Not phosphorylated1 Isoform 1: Polyneddylated. Isoform 2: Not Polyneddylated1 Isoform 1 and isoform 2: Not sumoylated1 Isoform 1 and isoform 2: Polyubiquitinated by herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110; leading to its subsequent proteasomal degradation. Isoform 1: Ubiquitinated at Lys-8691
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q93009 4/27 DME Specific Peptides for USP7 (Q93009 ) (see all 27 )USP7 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_003461.2 ENSEMBL proteins: ENSP00000343535 ENSP00000454362 ENSP00000371310 ENSP00000456258 ENSP00000454795 ENSP00000459594 ENSP00000458027 ENSP00000439272 ENSP00000456150 ENSP00000457237 ENSP00000455719 ENSP00000457815 ENSP00000443646 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing USP7 Antibody Products: Assay Products for USP7:
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Protein
Domains /for USP7 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q93009 ProtoNet protein and cluster: Q93009
2 Blocks protein families : IPB001394 IPB002083 UniProtKB/Swiss-Prot: UBP7_HUMAN, Q93009 Domain : The C-terminus plays a role in its oligomerization (By similarity)Similarity : Belongs to the peptidase C19 familySimilarity : Contains 1 MATH domain
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Functionfor USP7 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: UBP7_HUMAN, Q93009 Function : Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN andDAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1. Exhibits a preference towards 'Lys-48'-linked Ubiquitin chains Catalytic activity : Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) Enzyme regulation : Inhibited by N-ethyl-maleimide (NEM) and divalent cations. Tolerates high concentrations of NaCl butis inhibited at concentrations of 195 mM and higher Biophysicochemical properties : pH dependence: Active from pH 7.0 to 9.5;
Genatlas biochemistry entry for USP7 ubiquitin-specific protease 7,cellular,135kDa,transitory component of discrete nuclear structures (ND10),binding herpes virus type 1 immediate early protein Vmw 110,stimulating viral gene expression,deubiquitin enzyme family Enzyme Numbers (IUBMB): EC 3.1.2.15 2 EC 3.4.19.12 1 Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: USP7 (NM_001947 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP7 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat USP7
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP7
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10 ): About this table
About GeneDecksing 1 GenomeRNAi human phenotype for USP7 :Animal Models: Usp7 tm1Wgu for USP73 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Usp7) :About GeneDecksing
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Pathways & Interactionsfor USP7 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Protein Stability 2 Ubiquitin-Proteasome Dependent Proteolysis 3 p53 pathway 4 FoxO family signaling
Pathway sources See GeneCards unified pathways Show all pathways 1 1 2 About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for USP7 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/302 Interacting proteins for USP7 (Q93009 1 , 2 , 3 ENSP00000343535 4 via UniProtKB, MINT, STRING , and/or I2D (see all 302 )Interactant Interaction Details GeneCard External ID(s) USP11 P51784 2 , 3 ENSP00000218348 4 MINT-7999820 MINT-8001998 MINT-8001923 MINT-7999851 MINT-8010390 MINT-8001946 MINT-8000588 MINT-8001976 MINT-7999829 MINT-8000528 I2D:
score=3 STRING: ENSP00000218348 BMI1 P35226 2 , 3 ENSP00000365851 4 MINT-8001998 MINT-7999691 MINT-8001923 MINT-8001946 MINT-8000588 MINT-8001976 MINT-7999056 MINT-8010220 I2D:
score=2 STRING: ENSP00000365851 CBX8 Q9HC52 2 , 3 ENSP00000269385 4 MINT-8001998 MINT-8001923 MINT-7999851 MINT-8010390 MINT-8001946 MINT-8010174 MINT-7999732 MINT-8001976 MINT-8002022 MINT-8012683 I2D:
score=2 STRING: ENSP00000269385 TP53 P04637 1 , 2 , 3 ENSP00000269305 4 EBI-302474,EBI-366083 MINT-14904 MINT-15878 MINT-15877 MINT-4304022 MINT-8415355 MINT-15876 I2D:
score=6 STRING: ENSP00000269305 MDM2 Q00987 1 , 2 , 3 ENSP00000417281 4 EBI-302474,EBI-389668 MINT-6801769 MINT-6801754 MINT-6801662 MINT-6801730 MINT-8415355 I2D:
score=5 STRING: ENSP00000417281
About this table Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006283 transcription-coupled nucleotide-excision repair
IMP -- GO:0006511 ubiquitin-dependent protein catabolic process
IEA -- GO:0006917 induction of apoptosis
-- -- GO:0007275 multicellular organismal development
IEA -- GO:0010216 maintenance of DNA methylation
IMP --
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Drugs & Compoundsfor USP7 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Compounds for USP7 available from Tocris Bioscience About this table Compound Action
CAS
# P 22077 USP7 inhibitor [1247819-59-5] HBX 41108 Selective USP7 inhibitor [924296-39-9]
1 HMDB Compound for USP7 About this table Compound Synonyms
CAS
# PubMed Ids Water Dihydrogen oxide (see all 2 ) 7732-18-5 --
USP7 / UBP7
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Transcriptsfor USP7 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for USP7 gene: NM_003470.2 Unigene Cluster for USP7:
Ubiquitin specific peptidase 7 (herpes virus-associated) Hs.386939 [show with all ESTs ] Unigene Representative Sequence: NM_003470 18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22 ): ENST00000344836 (uc010uyj.1 uc002czk.2 uc002czl.2 ) ENST00000563961 ENST00000381886 ENST00000565455 ENST00000563085 (uc010uyk.1 ) ENST00000567113 ENST00000565883 ENST00000562615 ENST00000563043 ENST00000562051 ENST00000567692 ENST00000569448 ENST00000566131 ENST00000570256 ENST00000567329 ENST00000542333 (uc010uyl.1 )ENST00000566004 ENST00000569230 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: USP7 (NM_001947 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP7 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat USP7
Additional cDNA sequence: AK302481.1 AK302771.1 AK302872.1 AK302912.1 AK316441.1 AY376241.1 Z72499.1
24 DOTS entries : DT.98132136 DT.318985
DT.99927512 DT.100773763 DT.75133351 DT.40284319 DT.95318433 DT.95318391 DT.101963698 DT.92448484 DT.95318389 DT.102829762 DT.92001173 DT.112175 DT.120657149 DT.120657102 DT.40265842 DT.92448494 DT.95195090 DT.95318390 DT.95318395 DT.99994385 DT.91700463 DT.92011447 24/475 AceView cDNA sequences (see all 475 ):
AI282974 BM460684 BF108654 AA554251 CB142338 BQ230906 AU121223 BU180798 AL046721 BU188935 AI805002 BM458854 N74182 AI678801 Z44869 BM706819 AA969495 AA551789 AW076007 AI127404 BQ214380 BU622966 CF144254 BM466695 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for USP7 (see all 10 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21a · SP1 : - - - SP2 : - - - - SP3 : SP4 : SP5 : -
ExUns: 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b · 25c · 25d ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34a · 34b SP1 : - - - - - - SP2 : - - - - - - SP3 : SP4 : SP5 :
ECgene alternative splicing isoforms for USP7
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Expression for USP7 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section USP7 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTCACTAGTG
About this image USP7 expression in embryonic tissues and stem cells About this table 1 LifeMap In Vivo Development Anatomical Compartment/CellTissue Category (developmental path) Kidney Renal Vesicle Kidney Expression: Experimental details:
In-situ hybridization
See USP7 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for USP7 SOURCE GeneReport for Unigene cluster: Hs.386939 UniProtKB/Swiss-Prot: UBP7_HUMAN, Q93009 Tissue specificity : Widely expressed. Overexpressed in prostate cancerSABiosciences Expression via Pathway-Focused PCR Arrays including USP7 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP7
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Orthologsfor USP7 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for USP7 gene from 9/34 species (see all 34 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves USP71
ubiquitin specific peptidase 7 (herpes virus-associated)
85.95(n) 96(a)
395126 NM_204471.1 NP_989802.1
lizard Reptilia USP76
--
91(a)
1 ↔ 1
GL343263.1(1898530-1927499)
African clawed frog Amphibia Xl.290482
Xenopus laevis transcribed sequence with strong similarity more
82.91(n)
BQ735251.1
zebrafish Actinopterygii Dr.179052
Transcribed sequence with strong similarity to protein more
80.35(n)
AL714391.1
fruit fly Insecta Ubp64E3 1
protein deubiquitination ubiquitin-specific3 1
38(a) 3 54.78(n) 1 50.28(a) 1
32169 1 NM_132551.2 1 NP_572779.2 1
worm Secernentea H19N07.2b3 1
ubiquitin carboxyl-terminal hydrolase3 1
33(a) 3 47.56(n) 1 37.94(a) 1
V(11116640-11120749)3 179538 1 NM_073424.2 1 NP_505825.1 1
baker's yeast Saccharomycetes UBP15(YMR304W)4 1
Ubiquitin-specific protease involved in protein deubiquitination; more 4 1
48.69(n) 1 36.13(a) 1
13(874987-878679) 4 855350 1, 4 NP_014033.1 1, 4
thale cress eudicotyledons UBP131
ubiquitin carboxyl-terminal hydrolase 13
48.89(n) 38.78(a)
820364 NM_001202935.1 NP_001189864.1
rice Liliopsida Os.21852
Oryza sativa (japonica cultivar-group) putative ubiquitin more
74.66(n)
NM_191424.1
ENSEMBL Gene Tree for USP7 (if available)TreeFam Gene Tree for USP7 (if available)
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Paralogsfor USP7 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for USP7 gene USP24 2 USP40 2 USP47 2 USP18 2 USP34 2 USP9Y 2 USP9X 2 USP41 2 USP48 2 2 SIMAP similar genes for USP7 using alignment to 13 protein entries: UBP7_HUMAN (see all proteins ):USP40 USP48 About GeneDecksing 2 Pseudogenes.org Pseudogenes for USP7 PGOHUM00000248650 PGOHUM00000260090
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Genomic Variantsfor USP7 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 16 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for USP7 (8985951 - 9058371 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for USP7 2 CNVs 66933 66934 Human Gene Mutation Database (HGMD) : USP7 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor USP7 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 602519
OMIM disorders : --20/22 (see all 22 ): About MalaCards brooke-spiegler syndrome mulibrey nanism herpes simplex dilated cardiomyopathy cervical adenocarcinoma cardiomyopathy colon carcinoma adenocarcinoma cervicitis gastric cancer nasopharyngitis lung cancer prostate cancer breast cancer glioblastoma ataxia carcinoma neuroblastoma prostatitis immunodeficiency 8 Novoseek disease relationships for USP7 gene About this table
Human Genome Epidemiology (HuGE) Navigator: USP7 (3 documents) Export disorders for USP7 gene to outside databases
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Publicationsfor USP7 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for USP7 gene, integrated from 9 sources (see all 141 ):(articles sorted by number of sources associating them with USP7) Utopia : connect your pdf to the dynamic
Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization. (PubMed id 17651432) 1 , 2 , 9(2007) A dynamic role of HAUSP in the p53-Mdm2 pathway. (PubMed id 15053880) 1 , 2 , 9(2004) Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. (PubMed id 11923872) 1 , 2 , 9(2002) Molecular recognition of p53 and MDM2 by USP7/HAUSP. (PubMed id 16474402) 1 , 2 , 9(2006) Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. (PubMed id 16402859) 1 , 2 , 9(2006) The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. (PubMed id 18716620) 1 , 2 , 9(2008) Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. (PubMed id 12507430) 1 , 2 , 9(2002) The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. (PubMed id 18566590) 1 , 2 , 9(2008) Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP. (PubMed id 14506283) 1 , 2 , 9(2003) UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair. (PubMed id 22466611) 1 , 2 (2012)
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External Searches for USP7 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing USP7 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing USP7 gene
(According to HUGE )
About This Section --
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Specialized Databases showing USP7 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for USP7 gene: USP7 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor USP7 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for USP7 OriGene shRNA RFP for USP7 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for USP7 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for USP7 OriGene 3'-UTR Clone for USP7 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for USP7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for USP7 OriGene Custom Protein Services for USP7 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP7 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for USP7
Tocris compounds for USP7
USP7 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP7
ThermoFisher Antibody for USP7
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat USP7
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summary
for 
and Proteopedia 
for USP7 (
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
In-situ hybridization
