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USP7 Gene

protein-coding   GIFtS: 72
GCID: GC16M008985

Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated)

(Previous name: ubiquitin specific protease 7 (herpes virus-associated))
(Previous symbol: HAUSP)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated)1 2     Ubiquitin-Specific-Processing Protease 72 3
HAUSP1 2 3 5     TEF12
Ubiquitin Specific Protease 7 (Herpes Virus-Associated)1 2     Herpes Virus-Associated Ubiquitin-Specific Protease2
Deubiquitinating Enzyme 72 3     Ubiquitin Carboxyl-Terminal Hydrolase 72
Herpesvirus-Associated Ubiquitin-Specific Protease2 3     EC 3.4.19.123
Ubiquitin Thioesterase 72 3     EC 3.1.2.158

External Ids:    HGNC: 126301   Entrez Gene: 78742   Ensembl: ENSG000001875557   OMIM: 6025195   UniProtKB: Q930093   

Export aliases for USP7 gene to outside databases

Previous GC identifers: GC16M008792 GC16M009087 GC16M008953 GC16M008954 GC16M008894 GC16M008907


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for USP7 Gene:
USP7 (ubiquitin specific peptidase 7 (herpes virus-associated)) is a protein-coding gene. Diseases associated with USP7 include brooke-spiegler syndrome, and uv sensitive syndrome. GO annotations related to this gene include transcription factor binding and ubiquitin protein ligase binding. An important paralog of this gene is USP24.

UniProtKB/Swiss-Prot: UBP7_HUMAN, Q93009
Function: Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN
and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2
towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53
and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces
p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen
peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with
DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both
processes that are counteracted by PML. Involved in cell proliferation during early embryonic development.
Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA
damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing
UV-induced degradation of ERCC6. Contributes to the overall stabilization and trans-activation capability of the
herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of
DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1,
preventing their degradation and promoting DNA methylation by DNMT1. Exhibits a preference towards
'Lys-48'-linked Ubiquitin chains

summary for USP7 Gene:
Deubiquitinating enzymes (DUBs) are a group of proteases that catalyze the cleavage of protein-ubiquitin
bonds. By removing these modifications, DUBs counteract the activity of ubiquitin ligases, which add
ubiquitin molecules to target proteins.

Gene Wiki entry for USP7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP7 gene promoter:
         Max1   E47   Arnt   AREB6   Max   PPAR-gamma1   PPAR-gamma2   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP7 promoter sequence
   Search Chromatin IP Primers for USP7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.2   HGNC cytogenetic band: 16p13.3

USP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M008985:  view genomic region     (about GC identifiers)

Start:
8,985,951 bp from pter      End:
9,058,371 bp from pter
Size:
72,421 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UBP7_HUMAN, Q93009 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 7  
Size: 1102 amino acids; 128302 Da
Subunit: Monomer. Homodimer. Part of a complex with DAXX, MDM2, RASSF1 and USP7. Part of a complex with DAXX, MDM2
and USP7. Interacts with MDM2; the interaction is independent of p53/TP53. Interacts with DAXX; the interaction
is direct and independent of MDM2 and p53/TP53. Interacts with FOXO4; the interaction is enhanced in presence of
hydrogen peroxide and occurs independently of p53/TP53. Interacts with p53/TP53; the interaction is enhanced in
response to DNA damage; the interaction is impaired by TSPYL5. Interacts with PTEN; the interaction is direct.
Interacts with UBXN6. Interacts with ATXN1 and the strength of interaction is influenced by the length of the
poly-Gln region in ATXN1. A weaker interaction seen with mutants having longer poly-Gln regions. Interacts with
KIAA1530/UVSSA. Isoform 1 and isoform 2 interact with herpesvirus 1 trans-acting transcriptional protein
ICP0/VMW110. Interacts with Epstein-Barr virus EBNA1. EBNA1 shows a 10-fold higher affinity than p53/TP53 and can
compete with it for USP7 binding. Binding to ICP0/VMW110 may modulate the substrate specificity or activity of
USP7 to stabilize viral proteins. Interacts with MEX3C and antagonizes its ability to degrade mRNA. Interacts
with DNMT1 and UHRF1
Selected PDB 3D structures from and Proteopedia for USP7 (see all 18):
1NB8 (3D)        1NBF (3D)        1YY6 (3D)        1YZE (3D)        2F1W (3D)        2F1X (3D)    
Secondary accessions: A6NMY8
Alternative splicing: 2 isoforms:  Q93009-1   Q93009-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP7: NX_Q93009

Explore proteomics data for USP7 at MOPED

Post-translational modifications: 

  • Isoform 1: Phosphorylated. Isoform 1 is phosphorylated at positions Ser-18 and Ser-963. Isoform 2: Not
    phosphorylated1
  • Isoform 1: Polyneddylated. Isoform 2: Not Polyneddylated1
  • Isoform 1 and isoform 2: Not sumoylated1
  • Isoform 1 and isoform 2: Polyubiquitinated by herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110;
    leading to its subsequent proteasomal degradation. Isoform 1: Ubiquitinated at Lys-8691
  • Ubiquitination2 at Lys98, Lys148, Lys335, Lys420, Lys476, Lys479, Lys490, Lys523, Lys824, Lys841,
                                 Lys882, Lys934, Lys1033, Lys1096
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for USP7 (Q93009) (see all 27)
     ALQRVFY  CRVLLDN  NAYMLVY  ESKLSEV 


    See USP7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001273386.1  NP_001273387.1  NP_003461.2  

    ENSEMBL proteins: 
     ENSP00000343535   ENSP00000454362   ENSP00000371310   ENSP00000456258   ENSP00000454795  
     ENSP00000459594   ENSP00000458027   ENSP00000439272   ENSP00000456150   ENSP00000457237  
     ENSP00000455719   ENSP00000457815   ENSP00000443646  

    USP7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for USP7
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for USP7
    OriGene Protein Over-expression Lysate for USP7
    OriGene MassSpec for USP7
    OriGene Custom Protein Services for USP7
    GenScript Custom Purified and Recombinant Proteins Services for USP7
    Novus Biologicals USP7 Proteins
    Novus Biologicals USP7 Lysate
    Sino Biological Recombinant Protein for USP7
    Sino Biological Cell Lysate for USP7
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP7

    USP7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for USP7 
    OriGene Antibodies for USP7
    OriGene Custom Antibody Services for USP7
    Novus Biologicals USP7 Antibodies
    Abcam antibodies for USP7
    Cloud-Clone Corp. Antibodies for USP7
    ThermoFisher Antibodies for USP7
    LSBio Antibodies in human, mouse, rat for USP7

    USP7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP7
    Cloud-Clone Corp. CLIAs for USP7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    Selected InterPro protein domains (see all 6):
     IPR008974 TRAF-like
     IPR002083 MATH
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028889 UCH/PAN2

    Graphical View of Domain Structure for InterPro Entry Q93009

    ProtoNet protein and cluster: Q93009

    2 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB002083 Meprin/TRAF-like MATH


    UniProtKB/Swiss-Prot: UBP7_HUMAN, Q93009
    Domain: The C-terminus plays a role in its oligomerization (By similarity)
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 MATH domain
    Similarity: Contains 1 USP domain


    USP7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP7_HUMAN, Q93009
    Function: Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN
    and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2
    towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53
    and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces
    p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen
    peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with
    DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both
    processes that are counteracted by PML. Involved in cell proliferation during early embryonic development.
    Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA
    damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing
    UV-induced degradation of ERCC6. Contributes to the overall stabilization and trans-activation capability of the
    herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of
    DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1,
    preventing their degradation and promoting DNA methylation by DNMT1. Exhibits a preference towards
    'Lys-48'-linked Ubiquitin chains
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Enzyme regulation: Inhibited by N-ethyl-maleimide (NEM) and divalent cations. Tolerates high concentrations of
    NaCl but is inhibited at concentrations of 195 mM and higher
    Biophysicochemical properties: pH dependence: Active from pH 7.0 to 9.5;

         Genatlas biochemistry entry for USP7:
    ubiquitin-specific protease 7,cellular,135kDa,transitory component of discrete nuclear structures (ND10),binding
    herpes virus type 1 immediate early protein Vmw 110,stimulating viral gene expression,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IDA--
    GO:0004197cysteine-type endopeptidase activity IMP--
    GO:0004221ubiquitin thiolesterase activity IMP16964248
    GO:0004843ubiquitin-specific protease activity IMP11923872
    GO:0005515protein binding IPI11279055
         
    USP7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for USP7:
     Increased cell death in HCT116 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Usp7):
     behavior/neurological  embryogenesis  growth/size/body  mortality/aging  nervous system 

    USP7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Usp7tm1Wgu for USP7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP7

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP7:
    hsa-mir-16-5p (MIRT031560), hsa-mir-26a-5p (MIRT050139), hsa-mir-21-5p (MIRT030771), hsa-mir-3676-3p (MIRT052872), hsa-mir-615-3p (MIRT040289), hsa-mir-877-3p (MIRT036837), hsa-mir-935 (MIRT036643)

    Block miRNA regulation of human, mouse, rat USP7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP7 (see all 63):
    hsa-miR-3678-3p hsa-miR-579 hsa-miR-300 hsa-miR-4272 hsa-miR-4305 hsa-miR-765 hsa-let-7a-2* hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidUSP7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP7
    Predesigned siRNA for gene silencing in human, mouse, rat USP7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP7

    Clone
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    OriGene clones in human, mouse for USP7 (see all 6)
    OriGene ORF clones in mouse, rat for USP7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP7 (NM_001947)
    Sino Biological Human cDNA Clone for USP7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP7

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for USP7
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBP7_HUMAN, Q93009: Nucleus. Cytoplasm. Nucleus, PML body. Note=Present in a minority of ND10 nuclear bodies.
    Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing
    ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML
    and PTEN in promyelocytic leukemia protein (PML) nuclear bodies
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11279055
    GO:0005737cytoplasm ----
    GO:0005829cytosol IDA11279055
    GO:0016605PML body IEA--

    USP7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP7 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Herpes simplex infection0.33
    2Viral carcinogenesis
    Viral carcinogenesis
    3Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    4Protein Stability
    Protein Stability
    5p53 pathway
    p53 pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP7
        Ubiquitin-Proteasome Dependent Proteolysis

    1 Cell Signaling Technology (CST) Pathway for USP7
        Protein Stability

    2 BioSystems Pathways for USP7
        FoxO family signaling
    p53 pathway



    4 Kegg Pathways  (Kegg details for USP7):
        FoxO signaling pathway
    Herpes simplex infection
    Epstein-Barr virus infection
    Viral carcinogenesis


    USP7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including USP7: 
              Polycomb & Trithorax Complexes in human mouse rat
              Neurotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for USP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP7 (Q930091, 2, 3 ENSP000003435354) via UniProtKB, MINT, STRING, and/or I2D (see all 347)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206287Q065871, 2, 3EBI-302474,EBI-752313 MINT-7999820 MINT-7999745 MINT-8012697 MINT-8010240 MINT-8010390 MINT-8001946 I2D: score=2 
    ENSG00000226788Q065871, 2, 3EBI-302474,EBI-752313 MINT-7999820 MINT-7999745 MINT-8012697 MINT-8010240 MINT-8010390 MINT-8001946 I2D: score=2 
    ENSG00000228520Q065871, 2, 3EBI-302474,EBI-752313 MINT-7999820 MINT-7999745 MINT-8012697 MINT-8010240 MINT-8010390 MINT-8001946 I2D: score=2 
    ENSG00000231115Q065871, 2, 3EBI-302474,EBI-752313 MINT-7999820 MINT-7999745 MINT-8012697 MINT-8010240 MINT-8010390 MINT-8001946 I2D: score=2 
    RING1Q065871, 2, 3EBI-302474,EBI-752313 MINT-7999820 MINT-7999745 MINT-8012697 MINT-8010240 MINT-8010390 MINT-8001946 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006283transcription-coupled nucleotide-excision repair IMP--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0010216maintenance of DNA methylation IMP--
    GO:0016032viral process IEA--

    USP7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    9 ApexBio Compounds for USP7     About this table
    CompoundAction CAS #
    IU1potent and selective small-molecule inhibitor of Usp14[314245-33-5]
    LDN 57444Inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity[668467-91-2]
    NSC 632839 hydrochlorideInhibitor of ubiquitin isopeptidase activity[157654-67-6]
    P 22077Inhibitor of ubiquitin-specific protease (USP) 7[1247819-59-5]
    P005091Ubiquitin-specific protease 7 (USP7) inhibitor[882257-11-6]
    PR-619Cell-permeable, non selective, reversible deubiquitinases/deubiquitylases (DUBs) inhibitor[2645-32-1]
    SJB2-043novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. [63388-44-3]
    Vialinin AInhibitor of USP4, USP5/isopeptidase T (IsoT) and UCH-L1 DUB activity[858134-23-3]
    WP1130Cell permeable deubiquitinase (DUB) inhibitor[856243-80-6]

    Compounds for USP7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    P 22077USP7 inhibitor[1247819-59-5]
    HBX 41108Selective USP7 inhibitor[924296-39-9]
    IU1USP14 inhibitor[314245-33-5]
    LDN 57444Ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor[668467-91-2]
    NSC 632839 hydrochlorideInhibitor of ubiquitin isopeptidase activity[157654-67-6]

    1 HMDB Compound for USP7    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for USP7 gene (3 alternative transcripts): 
    NM_001286457.1  NM_001286458.1  NM_003470.2  

    Unigene Cluster for USP7:

    Ubiquitin specific peptidase 7 (herpes virus-associated)
    Hs.386939  [show with all ESTs]
    Unigene Representative Sequence: NM_003470
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000344836(uc010uyj.1 uc002czk.2 uc002czl.2) ENST00000563961
    ENST00000381886 ENST00000565455 ENST00000563085(uc010uyk.1) ENST00000567113
    ENST00000565883 ENST00000562615 ENST00000563043 ENST00000562051 ENST00000567692
    ENST00000569448 ENST00000566131 ENST00000570256 ENST00000567329 ENST00000542333(uc010uyl.1)
    ENST00000566004 ENST00000569230
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK302481.1 AK302771.1 AK302872.1 AK302912.1 AK316441.1 AY376241.1 Z72499.1 

    24 DOTS entries:

    DT.98132136  DT.318985  DT.99927512  DT.100773763  DT.75133351  DT.40284319  DT.95318433  DT.95318391 
    DT.101963698  DT.92448484  DT.95318389  DT.102829762  DT.92001173  DT.112175  DT.120657149  DT.120657102 
    DT.40265842  DT.92448494  DT.95195090  DT.95318390  DT.95318395  DT.99994385  DT.91700463  DT.92011447 

    Selected AceView cDNA sequences (see all 475):

    AI373477 BE504624 AI127404 BE549516 AA969495 BQ286629 BM832989 BE504157 
    Z72499 AI568235 BU737314 BG028760 Z44869 AL043501 AW076007 N50535 
    BF348836 BG826977 H99203 AW503499 AA770668 BM459765 BU429520 CA489777 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for USP7 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21a ·
    SP1:              -           -                                                                                                                       -         
    SP2:        -     -           -                                                                                                                       -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                  -         

    ExUns: 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b · 25c · 25d ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34a · 34b
    SP1:  -                       -           -           -     -                       -                                                         
    SP2:  -                       -           -           -     -                       -                                                         
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for USP7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    USP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCACTAGTG
    USP7 Expression
    About this image


    USP7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Thyroid (Endocrine System)
    USP7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.386939

    UniProtKB/Swiss-Prot: UBP7_HUMAN, Q93009
    Tissue specificity: Widely expressed. Overexpressed in prostate cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including USP7: 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USP7 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp71 , 5 ubiquitin specific peptidase 71, 5 92.56(n)1
    99.18(a)1
      16 (4.28 cM)5
    2528701  NM_001003918.21  NP_001003918.21 
     86895955 
    chicken
    (Gallus gallus)
    Aves USP71 ubiquitin specific peptidase 7 (herpes virus-associated) 85.95(n)
    96(a)
      395126  NM_204471.1  NP_989802.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP76
    ubiquitin specific peptidase 7 (herpes virus-assoc...
    91(a)
    1 ↔ 1
    GL343263.1(1898530-1927499)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.290482 Xenopus laevis transcribed sequence with strong similarity more 82.91(n)    BQ735251.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.179052 Transcribed sequence with strong similarity to protein more 80.35(n)    AL714391.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ubp64E3
    Usp71
    protein deubiquitination
    ubiquitin-specific protease3
    ubiquitin-specific protease 71
    38(a)3
    55.02(n)1
    50.91(a)1
      321691  NM_132551.21  NP_572779.21 
    worm
    (Caenorhabditis elegans)
    Secernentea H19N07.2b3
    math-331
    ubiquitin carboxyl-terminal hydrolase3
    math-331
    33(a)
    (best of 2)3
    48.03(n)1
    38.45(a)1
      V(11116640-11120749)3
    1795381  NM_001028841.31  NP_001024012.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP15(YMR304W)4
    UBP151
    Ubiquitin-specific protease involved in protein deubiquitination; more4
    UBP151
    48.83(n)1
    36.62(a)1
      13(874987-878679)4
    8553501, 4  NP_014033.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBP131 UBP13 49.25(n)
    39.08(a)
      820364  NM_001202935.1  NP_001189864.1 
    rice
    (Oryza sativa)
    Liliopsida Os.21852 Oryza sativa (japonica cultivar-group) putative ubiquitin more 74.66(n)    NM_191424.1 


    ENSEMBL Gene Tree for USP7 (if available)
    TreeFam Gene Tree for USP7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP7 gene
    USP242  USP182  USP482  USP412  USP402  USP472  USP342  USP9Y2  
    USP9X2  
    2 SIMAP similar genes for USP7 using alignment to 13 protein entries:     UBP7_HUMAN (see all proteins):
    USP40    USP48

    USP7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for USP7
    PGOHUM00000248650 PGOHUM00000260090


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for USP7 (see all 1970)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs800727361,2
    C--8985491(+) GATGGC/TGTCTA 1 -- ds50010--------
    rs1407761741,2
    --8985494(+) GGTGTC/GTAGAC 1 -- ds50010--------
    rs1496708981,2
    --8985497(+) GTCTAC/GACGTG 1 -- ds50010--------
    rs1738641,2
    C,F,H--8985519(-) GTGCCG/TTGACA 1 -- ds500117Minor allele frequency- T:0.01EA NA NS WA CSA 668
    rs1931014831,2
    --8985595(+) CACCGC/TGCCTG 1 -- ds50010--------
    rs1125927751,2
    F--8985646(+) TGCTCG/TTGTGT 1 -- ds50011Minor allele frequency- T:0.00CSA 1
    rs1455968581,2
    --8985681(+) TGACCA/GCAGGC 1 -- ds50010--------
    rs1868487441,2
    --8985698(+) TGTCAC/TGCAGT 1 -- ds50010--------
    rs1915611501,2
    --8985718(+) GGCTCA/CCCGCT 1 -- ds50010--------
    rs788931151,2
    C,F--8985734(+) GACTCC/TGAATG 1 -- ds50011Minor allele frequency- T:0.13WA 118

    HapMap Linkage Disequilibrium report for USP7 (8985951 - 9058371 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for USP7 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665907CNV Deletion23128226
    esv1715688CNV Insertion17803354
    esv987802CNV Insertion20482838
    nsv457399CNV Loss19166990
    nsv833135CNV Loss17160897
    esv26318CNV Loss19812545
    nsv905324CNV Gain21882294
    dgv2600n71CNV Gain21882294
    nsv457394CNV Gain19166990
    esv27013CNV Gain19812545

    Human Gene Mutation Database (HGMD): USP7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP7
    DNA2.0 Custom Variant and Variant Library Synthesis for USP7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602519    OMIM disorders: --

    Selected diseases for USP7 (see all 26):    
    About MalaCards
    brooke-spiegler syndrome    uv sensitive syndrome    mulibrey nanism    herpes simplex
    cervical adenocarcinoma    cockayne syndrome    brain cancer    dilated cardiomyopathy
    glioblastoma multiforme    kaposi's sarcoma    nasopharyngitis    adenocarcinoma
    sarcoma    cervicitis    acute myeloid leukemia    neuroblastoma
    ataxia    myeloid leukemia    colorectal cancer    prostate cancer


    USP7 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for USP7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 23.9 13 18418047 (7), 16596237 (2), 16402859 (1), 17651432 (1) (see all 6)
    nsclc 13.9 5 16450335 (2), 17280505 (1)
    solid tumor 13.8 1 9428630 (1)
    herpes simplex 12.5 1 14506283 (1)
    cancer 7.09 2 16082221 (1), 17380154 (1)
    necrosis 0 2 16402859 (1), 17651432 (1)
    adenocarcinoma 0 4 16450335 (3)
    carcinoma 0 3 16450335 (2)

    Genetic Association Database (GAD): USP7
    Human Genome Epidemiology (HuGE) Navigator: USP7 (3 documents)

    Export disorders for USP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for USP7 gene, integrated from 10 sources (see all 170):
    (articles sorted by number of sources associating them with USP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization. (PubMed id 17651432)1, 2, 9 Fernandez-Montalvan A.... Gerhartz B. (FEBS J. 2007)
    2. A dynamic role of HAUSP in the p53-Mdm2 pathway. (PubMed id 15053880)1, 2, 9 Li M.... Gu W. (Mol. Cell 2004)
    3. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. (PubMed id 11923872)1, 2, 9 Li M.... Gu W. (Nature 2002)
    4. Molecular recognition of p53 and MDM2 by USP7/HAUSP. (PubMed id 16474402)1, 2, 9 Sheng Y....Frappier L. (Nat. Struct. Mol. Biol. 2006)
    5. Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. (PubMed id 16402859)1, 2, 9 Hu M.... Shi Y. (PLoS Biol. 2006)
    6. The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. (PubMed id 18716620)1, 2, 9 Song M.S.... Pandolfi P.P. (Nature 2008)
    7. Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. (PubMed id 12507430)1, 2, 9 Hu M....Shi Y. (Cell 2002)
    8. The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. (PubMed id 18566590)1, 2, 9 Song M.S.... Lim D.S. (EMBO J. 2008)
    9. Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP. (PubMed id 14506283)1, 2, 9 Holowaty M.N.... Frappier L. (J. Biol. Chem. 2003)
    10. UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair. (PubMed id 22466611)1, 2 Schwertman P.... Marteijn J.A. (Nat. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7874 HGNC: 12630 AceView: USP7 Ensembl:ENSG00000187555 euGenes: HUgn7874
    ECgene: USP7 Kegg: 7874 H-InvDB: USP7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for USP7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for USP7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP7 gene:
    Search GeneIP for patents involving USP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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