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Aliases for USP6NL Gene

Aliases for USP6NL Gene

  • USP6 N-Terminal Like 2 3
  • Related To The N-Terminus Of Tre 3 4
  • RNTRE 3 6
  • USP6NL Intronic Transcript 1 (Non-Protein Coding) 2
  • Related To The N Terminus Of Tre 2
  • USP6 N-Terminal-Like Protein 3
  • USP6NL-IT1 3
  • KIAA0019 4
  • TRE2NL 3
  • RN-Tre 4

External Ids for USP6NL Gene

Previous HGNC Symbols for USP6NL Gene

  • USP6NL-IT1

Previous GeneCards Identifiers for USP6NL Gene

  • GC10M011506
  • GC10M011542
  • GC10M011502

Summaries for USP6NL Gene

GeneCards Summary for USP6NL Gene

USP6NL (USP6 N-Terminal Like) is a Protein Coding gene. Among its related pathways are ErbB1 downstream signaling and EGFR1 Signaling Pathway. An important paralog of this gene is TBC1D10B.

UniProtKB/Swiss-Prot for USP6NL Gene

  • Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex.

Gene Wiki entry for USP6NL Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP6NL Gene

Genomics for USP6NL Gene

Regulatory Elements for USP6NL Gene

Genomic Location for USP6NL Gene

Start:
11,453,946 bp from pter
End:
11,611,754 bp from pter
Size:
157,809 bases
Orientation:
Minus strand

Genomic View for USP6NL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP6NL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP6NL Gene

Proteins for USP6NL Gene

  • Protein details for USP6NL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92738-US6NL_HUMAN
    Recommended name:
    USP6 N-terminal-like protein
    Protein Accession:
    Q92738
    Secondary Accessions:
    • A8KA79
    • Q15400
    • Q5VV10
    • Q7L0K9

    Protein attributes for USP6NL Gene

    Size:
    828 amino acids
    Molecular mass:
    94104 Da
    Quaternary structure:
    • Interacts with EPS8.
    SequenceCaution:
    • Sequence=BAA02807.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for USP6NL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP6NL Gene

Proteomics data for USP6NL Gene at MOPED

Post-translational modifications for USP6NL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP6NL Gene

No data available for DME Specific Peptides for USP6NL Gene

Domains for USP6NL Gene

Protein Domains for USP6NL Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for USP6NL Gene

Graphical View of Domain Structure for InterPro Entry

Q92738

UniProtKB/Swiss-Prot:

US6NL_HUMAN :
  • Q92738
Domain:
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with USP6NL: view

No data available for Gene Families for USP6NL Gene

Function for USP6NL Gene

Molecular function for USP6NL Gene

UniProtKB/Swiss-Prot Function:
Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex.

Gene Ontology (GO) - Molecular Function for USP6NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 17562788
GO:0017137 Rab GTPase binding IPI 17562788
genes like me logo Genes that share ontologies with USP6NL: view

Animal Model Products

miRNA for USP6NL Gene

miRTarBase miRNAs that target USP6NL

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP6NL

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for USP6NL Gene

Localization for USP6NL Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP6NL Gene

Golgi apparatus. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP6NL Gene COMPARTMENTS Subcellular localization image for USP6NL gene
Compartment Confidence
golgi apparatus 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for USP6NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IDA 17562788
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0031410 cytoplasmic vesicle IDA 17684057
genes like me logo Genes that share ontologies with USP6NL: view

Pathways for USP6NL Gene

genes like me logo Genes that share pathways with USP6NL: view

Pathways by source for USP6NL Gene

2 BioSystems pathways for USP6NL Gene
1 GeneGo (Thomson Reuters) pathway for USP6NL Gene

Gene Ontology (GO) - Biological Process for USP6NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IMP 17684057
GO:0019068 virion assembly IMP 21680502
GO:0033126 obsolete positive regulation of GTP catabolic process --
GO:0035526 retrograde transport, plasma membrane to Golgi IMP 17684057
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with USP6NL: view

Transcripts for USP6NL Gene

Unigene Clusters for USP6NL Gene

USP6 N-terminal like:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP6NL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP6NL Gene

No ASD Table

Relevant External Links for USP6NL Gene

GeneLoc Exon Structure for
USP6NL
ECgene alternative splicing isoforms for
USP6NL

Expression for USP6NL Gene

mRNA expression in normal human tissues for USP6NL Gene

mRNA differential expression in normal tissues according to GTEx for USP6NL Gene

This gene is overexpressed in Esophagus - Mucosa (4.2).

Protein differential expression in normal tissues for USP6NL Gene

This gene is overexpressed in Placenta (32.9), Bone marrow stromal cell (18.3), and Blymphocyte (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP6NL Gene

SOURCE GeneReport for Unigene cluster for USP6NL Gene Hs.498661

mRNA Expression by UniProt/SwissProt for USP6NL Gene

Q92738-US6NL_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with USP6NL: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Expression partners for USP6NL Gene

Orthologs for USP6NL Gene

This gene was present in the common ancestor of animals.

Orthologs for USP6NL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia USP6NL 35
  • 82.08 (n)
  • 82.28 (a)
USP6NL 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP6NL 35
  • 84.25 (n)
  • 85.1 (a)
USP6NL 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp6nl 35
  • 81.37 (n)
  • 82.17 (a)
Usp6nl 16
Usp6nl 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia USP6NL 35
  • 99.33 (n)
  • 99.17 (a)
USP6NL 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp6nl 35
  • 81.4 (n)
  • 82.76 (a)
oppossum
(Monodelphis domestica)
Mammalia USP6NL 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP6NL 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP6NL 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP6NL 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp6nl 35
  • 77.74 (n)
  • 80.97 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.11936 35
usp6nl 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RN-tre 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tbc-17 36
  • 20 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3242 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToMany
Species with no ortholog for USP6NL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP6NL Gene

ENSEMBL:
Gene Tree for USP6NL (if available)
TreeFam:
Gene Tree for USP6NL (if available)

Paralogs for USP6NL Gene

Paralogs for USP6NL Gene

genes like me logo Genes that share paralogs with USP6NL: view

Variants for USP6NL Gene

Sequence variations from dbSNP and Humsavar for USP6NL Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs3489 -- 11,460,839(+) CTGCA(A/T)CAACA utr-variant-3-prime
rs754426 -- 11,587,404(+) ACTAT(A/C)CCTTG intron-variant
rs882205 -- 11,490,808(-) GCCCA(A/G)GGTCT intron-variant
rs882206 -- 11,490,759(-) CCTGT(G/T)GGCAC intron-variant
rs882207 -- 11,490,749(-) CATTT(C/T)TGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP6NL Gene

Variant ID Type Subtype PubMed ID
nsv831784 CNV Gain 17160897
esv2658637 CNV Deletion 23128226
esv2732984 CNV Deletion 23290073
esv2732995 CNV Deletion 23290073
nsv24455 CNV Insertion 16902084

Relevant External Links for USP6NL Gene

HapMap Linkage Disequilibrium report
USP6NL
Human Gene Mutation Database (HGMD)
USP6NL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP6NL Gene

Disorders for USP6NL Gene

Relevant External Links for USP6NL

Genetic Association Database (GAD)
USP6NL
Human Genome Epidemiology (HuGE) Navigator
USP6NL

No disorders were found for USP6NL Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for USP6NL Gene

Publications for USP6NL Gene

  1. RN-tre specifically binds to the SH3 domain of eps8 with high affinity and confers growth advantage to NIH3T3 upon carboxy-terminal truncation. (PMID: 8700527) MatA^skovA! B. … Di Fiore P.P. (Oncogene 1996) 2 3 23
  2. The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5. (PMID: 11099046) Lanzetti L. … Di Fiore P.P. (Nature 2000) 3 4 23
  3. Endocytosis of epidermal growth factor receptor regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre. (PMID: 12399475) Martinu L. … Chou M.M. (J. Biol. Chem. 2002) 2 3 23
  4. RN-tre identifies a family of tre-related proteins displaying a novel potential protein binding domain. (PMID: 8700515) Wong W.T. … Matoskova B. (Oncogene 1996) 2 3 4
  5. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3 4 23

Products for USP6NL Gene

Sources for USP6NL Gene

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