Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP6 Gene

protein-coding   GIFtS: 60
GCID: GC17P005019

ubiquitin specific peptidase 6 (Tre-2 oncogene)

(Previous name: ubiquitin specific protease 6 (Tre-2 oncogene) )
(Previous symbol: HRP1)
 Explore 12 diseases affiliated with
USP6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for USP6    

Aliases
for USP6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ubiquitin Specific Peptidase 6 (Tre-2 Oncogene)1 2     USP6-Short1
HRP11 2 3     Hyperpolymorphic Gene 12
TRE22 3 5     TBC1D3 And USP32 Fusion2
TRE171 2     Tre-2 Oncogene2
Tre-21 2     Ubiquitin Carboxyl-Terminal Hydrolase 62
Ubiquitin Specific Protease 6 (Tre-2 Oncogene)1 2     Ubiquitin Specific Peptidase 6-2
Deubiquitinating Enzyme 62 3     Ubiquitin Thiolesterase 62
Proto-Oncogene TRE-22 3     Ubiquitin-Specific Protease USP62
Ubiquitin Thioesterase 62 3     EC 3.4.19.123
Ubiquitin-Specific-Processing Protease 62 3     EC 3.1.2.158
Tre21     

External Ids:    HGNC: 126291   Entrez Gene: 90982   Ensembl: ENSG000001292047   OMIM: 6043345   UniProtKB: P351253   

Export aliases for USP6 gene to outside databases

Previous GC identifers: GC17P005451 GC17P005369 GC17P004976 GC17P005232 GC17P004972 GC17P004921


Summaries
for USP6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: UBP6_HUMAN, P35125
Function: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin
moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity.
Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking.
Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B
activation

Gene Wiki entry for USP6


Genomic Views
for USP6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP6 gene promoter:
         GR   AP-2alpha isoform 3   GR-beta   AP-2alpha isoform 2   YY1   PPAR-alpha   GR-alpha   AP-2alpha isoform 4   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: USP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13

USP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP6 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P005019:  view genomic region     (about GC identifiers)

Start:
 5,019,733 bp from pter      End:
 5,078,329 bp from pter
Size:
 58,597 bases      Orientation:
 plus strand

Proteins
for USP6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UBP6_HUMAN, P35125 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 6  
Size: 1406 amino acids; 158658 Da
Subunit: Interacts with RAC1 and CDC42. Interacts (via Rab-GAP TBC domain) with ARF6. Interacts with calmodulin (CALM1,
CALM2 and/or CALM3); the interaction is calcium-dependent
Subcellular location: Cell membrane. Cytoplasm. Endosome. Note=Localizes to the plasma membrane and to filamentous
structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct
the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton
Miscellaneous: The USP6 gene only exists in the primate lineage
Secondary accessions: Q15634 Q86WP6 Q8IWT4
Alternative splicing: 3 isoforms:  P35125-1   P35125-2   P35125-3   (Was shown to be tumorigenic in transfected mice and seems not to act as GTPase activating protein)

Explore the universe of human proteins at neXtProt for USP6: NX_P35125

Post-translational modifications:

  • Monubiquitinated; ubiquitination is calmodulin and calcium dependent1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P35125

    • 4/6 DME Specific Peptides for USP6 (P35125) (see all 6)
     NLGNTCF  FLLDGLH  LIIHLKR  GNTCFMN 

    USP6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004496.2  
    ENSEMBL proteins: 
     ENSP00000460380   ENSP00000461817   ENSP00000461581   ENSP00000250066   ENSP00000328010  
     ENSP00000305473  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for USP6 
    GenScript Custom Purified and Recombinant Proteins Services for USP6
    Novus Biologicals USP6 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for USP6

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA12612085
    GO:0005764lysosome TAS9827704
    GO:0005886plasma membrane IDA12612085
    GO:0055037recycling endosome IDA15509780


    USP6 for ontologies           About GeneDecksing



    USP6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for USP6 
    GenScript Custom Superior Antibodies Services for USP6
    Novus Biologicals USP6 Antibodies
    Search for Antibodies for USP6 at Abcam  
    Uscn Antibodies for USP6
    Search ThermoFisher Antibodies for USP6

    Assay Products for USP6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP6
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for USP6

    Protein Domains /
    Families
    for USP6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    USP6 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001394 Peptidase_C19
     IPR000195 Rab-GTPase-TBC_dom
     IPR018200 Pept_C19ubi-hydrolase_C_CS

    Graphical View of Domain Structure for InterPro Entry P35125

    ProtoNet protein and cluster: P35125

    2 Blocks protein families:
    IPB000195 RabGAP/TBC domain
    IPB001394 Ubiquitin thiolesterase


    UniProtKB/Swiss-Prot: UBP6_HUMAN, P35125
    Domain: The Rab-GAP TBC domain lacks GTPase activator activity but is necessary for interaction with ARF6
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 Rab-GAP TBC domain


    Function
    for USP6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UBP6_HUMAN, P35125
    Function: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin
    moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity.
    Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking.
    Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B
    activation
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the
    C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP6:
    ubiquitin specific protease 6,hyperpolymorphic gene 1,deubiquitin enzyme family

    Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

    miRNA
    Products:            		 OriGene 3'-UTR Clone: USP6
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP6
    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate USP6 (see all 78):
    hsa-miR-300 hsa-miR-411 hsa-miR-106a hsa-miR-938 hsa-miR-519a hsa-miR-371-5p hsa-miR-4275 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: USP6 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP6
    OriGene shRNA RFP: USP6
    OriGene siRNA: USP6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for USP6

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP6
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP6 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): USP6 (NM_001946)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP6 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for USP6
    Search LifeMap BioReagents cell lines for USP6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP6

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding TAS1565468
    GO:0004197cysteine-type endopeptidase activity TAS9827704
    GO:0004221ubiquitin thiolesterase activity IEA--
    GO:0004843ubiquitin-specific protease activity IDA16127172
    GO:0005097Rab GTPase activator activity IEA--


    USP6 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for USP6:
     Decreased p24 protein expressi  G0/1 arrest  Increased G1 DNA content  Synthetic lethal with Ras 


    Pathways & Interactions
    for USP6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Arf6 signaling events
    		Arf6 signaling events1.00
    2Ubiquitin-Proteasome Dependent Proteolysis
    		Ubiquitin-Proteasome Dependent Proteolysis1.00

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP6
        Ubiquitin-Proteasome Dependent Proteolysis

    1 BioSystems Pathway for USP6 
        Arf6 signaling events


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/14 Interacting proteins for USP6 (P351251, 2, 3 ENSP000002500664) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN7L3Q14CW92, 3, ENSP000003972594MINT-2865886 I2D: score=3 STRING: ENSP00000397259
    MYL2P109161, 3, ENSP000002288414EBI-954590,EBI-725770 I2D: score=1 STRING: ENSP00000228841
    CALM2P621583, ENSP000002722984I2D: score=1 STRING: ENSP00000272298
    CALM1P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process NAS9827704
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016579protein deubiquitination IDA16127172
    GO:0060627regulation of vesicle-mediated transport IDA15509780


    USP6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for USP6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP6

    1 HMDB Compound for USP6    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about USP6 / UBP6 

    Transcripts
    for USP6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for USP6 gene (2 alternative transcripts): 
    NM_005152.1  NM_004505.2  

    Unigene Cluster for USP6:

    Ubiquitin specific peptidase 6 (Tre-2 oncogene)
    Hs.448851  [show with all ESTs]
    Unigene Representative Sequence: BX647719
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000574788(uc002gau.1) ENST00000575709 ENST00000572949 ENST00000250066(uc002gav.1)
    ENST00000572429 ENST00000357482(uc002gaw.3) ENST00000332776 ENST00000304328(uc010ckz.1)


    miRNA
    Products:             		 OriGene 3'-UTR Clone: USP6
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP6
    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate USP6 (see all 78):
    hsa-miR-300 hsa-miR-411 hsa-miR-106a hsa-miR-938 hsa-miR-519a hsa-miR-371-5p hsa-miR-4275 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: USP6 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP6
    OriGene shRNA RFP: USP6
    OriGene siRNA: USP6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP6
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP6
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP6 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): USP6 (NM_001946)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP6 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat USP6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP6

    Additional cDNA sequence: 

    AB449915.1 AY143550.1 BX647719.1 HQ326700.1 X78261.1 

    9 DOTS entries:

    DT.100037996  DT.100824934  DT.101984339  DT.120915753  DT.102834044  DT.304019  DT.95289961  DT.120953569 
    DT.97776537 

    24/50 AceView cDNA sequences (see all 50):

    AL042528 AL042432 BE044069 AL044255 AL041793 BC029495 AY143550 BI461261 
    BV204923 AI147443 BV204922 AA922552 X63547 BV202001 BV200185 BV200180 
    BV200186 BX503609 AI419876 BX508457 AL696358 BV200184 BX280485 BV200187 

    GeneLoc Exon Structure


    Expression
    for USP6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See USP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP6

    SOURCE GeneReport for Unigene cluster: Hs.448851

    UniProtKB/Swiss-Prot: UBP6_HUMAN, P35125
    Tissue specificity: Testis specific. Expressed in various cancer cell lines

        SABiosciences Custom PCR Arrays for USP6
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat USP6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP6
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP6

    Orthologs
    for USP6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for USP6 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves USP6NL6
    		 Uncharacterized protein
    		 27(a)
    		 1 → many
    		 5(17180663-17259945)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 34(a)
    		 1 → many
    		 1(74862925-74883702)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.118642 Transcribed sequences 85.12(n)    CF242629.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-288d18.16
    si:dkeyp-19e1.36
    		 si:dkeyp-19e1.3
    		 23(a)
    21(a)
    		 many ↔ many
    many ↔ many
    		 7(50477638-50513235)
    25(24844950-24903338)
    fruit fly
    (Drosophila melanogaster)    		 Insecta RN-tre6
    		 tre oncogene-related protein
    		 18(a)
    		 1 → many
    		 2R(9872320-9878215)
    worm
    (Caenorhabditis elegans)    		 Secernentea H34C03.23 ubiquitin carboxy-terminal hydrolase 51(a)   IV(6757531-6761964)   --


    ENSEMBL Gene Tree for USP6 (if available)
    TreeFam Gene Tree for USP6 (if available) 

    Paralogs
    for USP6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP6 gene
    USP152  USP112  USP312  USP322  USP432  USP192  USP42  
    13 SIMAP similar genes for USP6 using alignment to 2 protein entries:     UBP6_HUMAN (see all proteins):
    USP6-short    tre    USP32    TBC1D3F    TBC1D3G    TBC1D3H
    TBC1D3C    TBC1D3B    TBC1D3    TBC1D29    USP15    DKFZp761E10121
    USP11

    USP6 for paralogs           About GeneDecksing


    5/19 Pseudogenes.org Pseudogenes for USP6 (see all 19)
    PGOHUM00000250808 PGOHUM00000237001 PGOHUM00000237047 PGOHUM00000237053 PGOHUM00000237061


    Genomic Variants
    for USP6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/838 NCBI SNPs in USP6 are shown (see all 838)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1889558151,2
    		--5029824(+) ATCAAC/GAGTAA 1 -- us2k10--------
    rs1148421851,2
    		F,--5029835(+) CTCGAC/TCTCCT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs129508551,2
    		C,--5030059(+) GACGGT/CTGGAC 1 -- us2k112Minor allele frequency- C:0.01NA WA CSA EA 373
    rs1125055601,2
    		C,--5030243(+) CCCACA/GTGGCT 1 -- us2k10--------
    rs1863138651,2
    		--5030297(+) ACCTGC/GCCACG 1 -- us2k10--------
    rs65028451,2
    		C,--5030527(+) TCCGCA/CGCCCC 1 -- us2k14Minor allele frequency- C:0.12NA WA 8
    rs1141494141,2
    		F,--5030831(+) GGAGTC/TGGGGG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1502143471,2
    		--5031040(+) ACCTAA/GTATTT 1 -- us2k10--------
    rs1389003021,2
    		--5031090(+) ATCTCG/TAGATT 1 -- us2k10--------
    rs1900293061,2
    		--5031174(+) ACAACA/GTCTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for USP6 (5019733 - 5078329 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for USP6
         1 CNV: 72779

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP6
    DNA2.0 Custom Variant and Variant Library Synthesis for USP6

    Disorders / Diseases
    for USP6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    USP6 for disorders           About GeneDecksing

    OMIM gene information: 604334    OMIM disorders: --

    UniProtKB/Swiss-Prot: UBP6_HUMAN, P35125
  • Note=A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign
    • osseous neoplasm. Translocation t(16;17)(q22;p13) with CDH11. The translocation generates a fusion gene in which the
    strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation

    12 diseases for USP6:    About MalaCards
    telangiectatic osteogenic sarcoma    giant cell reparative granuloma    aneurysmal bone cysts    myositis ossificans
    cherubism    chondroblastoma    myositis    bone cancer
    sarcoma    neuropathy    ataxia    malaria

    2 diseases from the University of Copenhagen DISEASES database for USP6:
    Telangiectatic osteogenic sarcoma     Childhood kidney cell carcinoma
    Human Genome Epidemiology (HuGE) Navigator: USP6 (1 document)

    Export disorders for USP6 gene to outside databases

    Publications
    for USP6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP6 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with USP6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst. (PubMed id 15026324)1, 2, 9 Oliveira A.M.... Fletcher J.A. (2004)
    2. The Tre2 (USP6) oncogene is a hominoid-specific gene. (PubMed id 12604796)1, 2, 9 Paulding C.A.... Haber D.A. (2003)
    3. Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene. (PubMed id 14521938)1, 2, 9 Bizimungu C.... Vandenbol M. (2003)
    4. TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB. (PubMed id 20418905)1, 2 Ye Y.... Chou M.M. (2010)
    5. Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6. (PubMed id 16127172)1, 2 Shen C....Chou M.M. (2005)
    6. The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6. (PubMed id 15509780)1, 2 Martinu L....Chou M.M. (2004)
    7. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    8. The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling. (PubMed id 12612085)1, 2 Masuda-Robens J.M....Chou M.M. (2003)
    9. The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene. (PubMed id 8247125)1, 2 Papa F.R. and Hochstrasser M. (1993)
    10. De-novo mutation in hereditary motor and sensory neuropathy type I. (PubMed id 1349106)1, 3 Hoogendijk J.E....Baas F. (1992)

    External Searches for USP6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing USP6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9098 HGNC: 12629 AceView: USP6 Ensembl:ENSG00000129204 euGenes: HUgn9098
    ECgene: USP6 H-InvDB: USP6

    Other Databases showing USP6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing USP6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for USP6 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for USP6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for USP6 gene:
    Search GeneIP for patents involving USP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for USP6 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for USP6  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP6   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP6  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for USP6   OriGene 3'-UTR Clone for USP6  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP6   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP6  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for USP6   OriGene Custom Protein Services for USP6  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP6
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP6
     GenScript Custom Purified and Recombinant Proteins Services for USP6 GenScript cDNA clones with any tag delivered in your preferred vector for USP6
     GenScript Custom Assay Services for USP6 GenScript Custom Superior Antibodies Services for USP6
     GenScript Custom overexpressing Cell Line Services for USP6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in USP6 promoter
     Search Chromatin IP Primers for USP6
     RT2 qPCR Primer Assay in human, mouse / rat USP6
     Search GNC Networks for USP6
     SABiosciences PCR Arrays including human, mouse, rat USP6
     Search Tocris compounds for USP6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     USP6 antibodies
     USP6 proteins
     Search for Antibodies for USP6 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for USP6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     USP6 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for USP6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP6
     SwitchGear 3'UTR luciferase reporter plasmids for USP6
     SwitchGear Promoter luciferase reporter plasmids for USP6
     Search ThermoFisher Antibodies for USP6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP6
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      USP6 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4