Free for academic non-profit institutions. Other users need a Commercial license

Aliases for USP6 Gene

Aliases for USP6 Gene

  • Ubiquitin Specific Peptidase 6 2 3
  • TRE2 3 4 6
  • Ubiquitin Specific Peptidase 6 (Tre-2 Oncogene) 2 3
  • Ubiquitin Specific Protease 6 (Tre-2 Oncogene) 2 3
  • Ubiquitin-Specific-Processing Protease 6 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 6 2 3
  • Deubiquitinating Enzyme 6 3 4
  • Ubiquitin Thioesterase 6 3 4
  • TBC1D3 And USP32 Fusion 2 3
  • Proto-Oncogene TRE-2 3 4
  • HRP1 3 4
  • TRE Oncogene, Smith Magenis Syndrome Chromosome Region 2
  • Ubiquitin-Specific Protease USP6 3
  • Ubiquitin Thiolesterase 6 3
  • Hyperpolymorphic Gene 1 3
  • Tre-2 Oncogene 2
  • EC 3.4.19.12 4
  • EC 3.1.2.15 64
  • USP6-Short 3
  • TRESMCR 3
  • TRE17 3
  • Tre-2 3

External Ids for USP6 Gene

Previous Symbols for USP6 Gene

  • HRP1
  • TRESMCR

Summaries for USP6 Gene

GeneCards Summary for USP6 Gene

USP6 (Ubiquitin Specific Peptidase 6) is a Protein Coding gene. Diseases associated with USP6 include telangiectatic osteogenic sarcoma and aneurysmal bone cysts. Among its related pathways are Arf6 signaling events and Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include nucleic acid binding and ubiquitin thiolesterase activity. An important paralog of this gene is USP4.

UniProtKB/Swiss-Prot for USP6 Gene

  • Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.

Gene Wiki entry for USP6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP6 Gene

Genomics for USP6 Gene

Genomic Location for USP6 Gene

Start:
5,116,438 bp from pter
End:
5,175,034 bp from pter
Size:
58,597 bases
Orientation:
Plus strand

Genomic View for USP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP6 Gene

Proteins for USP6 Gene

  • Protein details for USP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35125-UBP6_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 6
    Protein Accession:
    P35125
    Secondary Accessions:
    • Q15634
    • Q86WP6
    • Q8IWT4

    Protein attributes for USP6 Gene

    Size:
    1406 amino acids
    Molecular mass:
    158658 Da
    Quaternary structure:
    • Interacts with RAC1 and CDC42. Interacts (via Rab-GAP TBC domain) with ARF6. Interacts with calmodulin (CALM1, CALM2 and/or CALM3); the interaction is calcium-dependent.
    Miscellaneous:
    • The USP6 gene only exists in the primate lineage

    Alternative splice isoforms for USP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP6 Gene

Proteomics data for USP6 Gene at MOPED

Selected DME Specific Peptides for USP6 Gene

Post-translational modifications for USP6 Gene

  • Monubiquitinated; ubiquitination is calmodulin and calcium dependent.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP6 Gene

Domains for USP6 Gene

Gene Families for USP6 Gene

HGNC:
  • USP :Ubiquitin-specific peptidases

UniProtKB/Swiss-Prot:

UBP6_HUMAN
Domain:
  • The Rab-GAP TBC domain lacks GTPase activator activity but is necessary for interaction with ARF6:
    • P35125
  • Contains 1 Rab-GAP TBC domain.:
    • P35125
  • Contains 1 USP domain.:
    • P35125
Family:
  • Belongs to the peptidase C19 family.:
    • P35125
genes like me logo Genes that share domains with USP6: view

Function for USP6 Gene

Molecular function for USP6 Gene

GENATLAS Biochemistry: ubiquitin specific protease 6,hyperpolymorphic gene 1,deubiquitin enzyme family
UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
UniProtKB/Swiss-Prot Function: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.

Enzyme Numbers (IUBMB) for USP6 Gene

Gene Ontology (GO) - Molecular Function for USP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding TAS 1565468
GO:0004197 cysteine-type endopeptidase activity TAS 9827704
GO:0004843 ubiquitin-specific protease activity IDA 16127172
GO:0005515 protein binding IPI 12612085
GO:0005516 calmodulin binding IPI 16127172
genes like me logo Genes that share ontologies with USP6: view

Phenotypes for USP6 Gene

genes like me logo Genes that share phenotypes with USP6: view

miRNA for USP6 Gene

miRTarBase miRNAs that target USP6

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for USP6 Gene

Localization for USP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP6 Gene

Cell membrane. Cytoplasm. Endosome. Note=Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP6 Gene COMPARTMENTS Subcellular localization image for USP6 gene
Compartment Confidence
endosome 5
plasma membrane 5
lysosome 4
vacuole 4
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for USP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12612085
GO:0005764 lysosome TAS 9827704
GO:0005886 plasma membrane IDA 12612085
GO:0055037 recycling endosome IDA 15509780
genes like me logo Genes that share ontologies with USP6: view

Pathways for USP6 Gene

genes like me logo Genes that share pathways with USP6: view

Pathways by source for USP6 Gene

1 Qiagen pathway for USP6 Gene
1 BioSystems pathway for USP6 Gene

Gene Ontology (GO) - Biological Process for USP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process NAS 9827704
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0016579 protein deubiquitination IDA 16127172
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0060627 regulation of vesicle-mediated transport IDA 15509780
genes like me logo Genes that share ontologies with USP6: view

Compounds for USP6 Gene

(1) HMDB Compounds for USP6 Gene

Compound Synonyms Cas Number PubMed IDs
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with USP6: view

Transcripts for USP6 Gene

Unigene Clusters for USP6 Gene

Ubiquitin specific peptidase 6 (Tre-2 oncogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP6 Gene

No ASD Table

Relevant External Links for USP6 Gene

GeneLoc Exon Structure for
USP6
ECgene alternative splicing isoforms for
USP6

Expression for USP6 Gene

mRNA expression in normal human tissues for USP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP6 Gene

This gene is overexpressed in Muscle - Skeletal (17.6) and Testis (10.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP6 Gene

SOURCE GeneReport for Unigene cluster for USP6 Gene Hs.448851

mRNA Expression by UniProt/SwissProt for USP6 Gene

P35125-UBP6_HUMAN
Tissue specificity: Testis specific. Expressed in various cancer cell lines.
genes like me logo Genes that share expressions with USP6: view

Orthologs for USP6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP6 36
  • 98.77 (n)
  • 97.72 (a)
USP6 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 58 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 56 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Usp32 37
  • 56 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 54 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 53 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 43 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11864 36
zebrafish
(Danio rerio)
Actinopterygii usp32 37
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8334 37
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea H34C03.2 38
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP12 37
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToMany
Species with no ortholog for USP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP6 Gene

ENSEMBL:
Gene Tree for USP6 (if available)
TreeFam:
Gene Tree for USP6 (if available)

Paralogs for USP6 Gene

Paralogs for USP6 Gene

Selected SIMAP similar genes for USP6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with USP6: view

Variants for USP6 Gene

Sequence variations from dbSNP and Humsavar for USP6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs703850 -- 5,173,778(+) GCCCC(A/G)CCCAT utr-variant-3-prime
rs934631 -- 5,172,543(-) tgtat(G/T)tattt intron-variant
rs1053524 -- 5,173,637(+) GAGCT(A/G)TGTGC utr-variant-3-prime
rs1053527 -- 5,173,865(+) GTAAG(C/T)GGCAT utr-variant-3-prime
rs1053529 -- 5,173,903(+) TGGTT(A/C/G)TTCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for USP6 Gene

Variant ID Type Subtype PubMed ID
nsv907620 CNV Loss 21882294
nsv907624 CNV Loss 21882294
esv25210 CNV Gain 19812545

Relevant External Links for USP6 Gene

HapMap Linkage Disequilibrium report
USP6

Disorders for USP6 Gene

UniProtKB/Swiss-Prot

UBP6_HUMAN
  • Note=A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with CDH11. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.

(2) University of Copenhagen DISEASES for USP6 Gene

Relevant External Links for USP6

Genetic Association Database (GAD)
USP6
Human Genome Epidemiology (HuGE) Navigator
USP6
genes like me logo Genes that share disorders with USP6: view

Publications for USP6 Gene

  1. The Tre2 (USP6) oncogene is a hominoid-specific gene. (PMID: 12604796) Paulding C.A. … Haber D.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23
  2. Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene. (PMID: 14521938) Bizimungu C. … Vandenbol M. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  3. USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst. (PMID: 15026324) Oliveira A.M. … Fletcher J.A. (Cancer Res. 2004) 3 4 23
  4. De-novo mutation in hereditary motor and sensory neuropathy type I. (PMID: 1349106) Hoogendijk J.E. … Baas F. (Lancet 1992) 2 3
  5. A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells. (PMID: 1565468) Nakamura T. … Hill M. (Oncogene 1992) 3 4

Products for USP6 Gene

Sources for USP6 Gene

Back to Top

Content