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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP54 Gene

protein-coding   GIFtS: 51
GCID: GC10M075257

Ubiquitin Specific Peptidase 54

(Previous names: chromosome 10 open reading frame 29, ubiquitin specific...)
(Previous symbol: C10orf29)
Alzheimer's & Parkinson's Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 541 2     bA137L10.32
C10orf291 2 3     bA137L10.42
Ubiquitin Specific Protease 541 2     Inactive Ubiquitin Carboxyl-Terminal Hydrolase 542
Inactive Ubiquitin-Specific Peptidase 542 3     Ubiquitin Specific Proteinase 542
Chromosome 10 Open Reading Frame 291     

External Ids:    HGNC: 235131   Entrez Gene: 1591952   Ensembl: ENSG000001663487   UniProtKB: Q70EL13   

Export aliases for USP54 gene to outside databases

Previous GC identifers: GC10M074601 GC10M074602 GC10M074927 GC10M069250


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for USP54 Gene: 
USP54 (ubiquitin specific peptidase 54) is a protein-coding gene. Diseases associated with USP54 include alzheimer's disease. GO annotations related to this gene include protein binding and ubiquitin thiolesterase activity. An important paralog of this gene is USP53.

UniProtKB/Swiss-Prot: UBP54_HUMAN, Q70EL1
Function: Has no peptidase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP54 gene promoter:
         Bach1   NF-1   AML1a   POU6F1 (c2)   C/EBPalpha   E47   GATA-1   c-Rel   GATA-6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP54 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP54

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP54


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.2   Ensembl cytogenetic band:  10q22.2   HGNC cytogenetic band: 10q22.3

USP54 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP54 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M075257:  view genomic region     (about GC identifiers)

Start:
75,257,296 bp from pter      End:
75,385,711 bp from pter
Size:
128,416 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP54_HUMAN, Q70EL1 (See protein sequence)
Recommended Name: Inactive ubiquitin carboxyl-terminal hydrolase 54  
Size: 1684 amino acids; 187388 Da
Caution: Although the active site residues are conserved, it lacks the conserved His residue which is normally
found 9 residues before the catalytic His
Sequence caution: Sequence=BAC04393.1; Type=Erroneous initiation; Sequence=BAG53943.1; Type=Erroneous initiation;
Sequence=BX649087; Type=Frameshift; Positions=508; Sequence=CAO03507.1; Type=Erroneous gene model prediction;
Sequence=CAO03508.1; Type=Erroneous gene model prediction; Sequence=CAO03509.1; Type=Erroneous gene model
prediction;
Secondary accessions: A1L4Q4 A3KFK3 A3KFK5 A3KFK6 A3KFK7 A6PVS4 A6PVS5 A6PVS6 A6PVS7 B3KVY1
B9ZVM1 Q5F2F4 Q6P1N6 Q6ZSP1 Q6ZSR1 Q6ZTM0 Q8N1X2
Alternative splicing: 7 isoforms:  Q70EL1-1   Q70EL1-4   Q70EL1-6   Q70EL1-7   Q70EL1-8   Q70EL1-9   Q70EL1-10   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP54: NX_Q70EL1

Explore proteomics data for USP54 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q70EL1

  • USP54 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP54 Protein Expression
    REFSEQ proteins: NP_689799.3  
    ENSEMBL proteins: 
     ENSP00000404644   ENSP00000473466   ENSP00000399972   ENSP00000345216   ENSP00000402435  
     ENSP00000404710   ENSP00000407245   ENSP00000386080   ENSP00000408714   ENSP00000407368  
     ENSP00000378290   ENSP00000326547  

    Human Recombinant Protein Products for USP54: 
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    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for USP54 


    USP54 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for USP54 

    Assay Products for USP54: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for USP54 
    Cloud-Clone Corp. CLIAs for USP54


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    1 InterPro protein domain:
     IPR001394 Peptidase_C19

    Graphical View of Domain Structure for InterPro Entry Q70EL1

    ProtoNet protein and cluster: Q70EL1

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP54_HUMAN, Q70EL1
    Similarity: Belongs to the peptidase C19 family


    USP54 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP54_HUMAN, Q70EL1
    Function: Has no peptidase activity

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IEA--
    GO:0005515protein binding IPI16713569
         
    USP54 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for USP54:
     Decreased Hepatitis C virus re 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for USP54 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP54

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP54 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP54 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP54
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate USP54 (see all 31):
    hsa-miR-345 hsa-miR-4307 hsa-miR-3152-3p hsa-miR-607 hsa-miR-520d-5p hsa-miR-106a hsa-miR-1285 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidUSP54 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of USP54

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for USP54
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    GenScript: all cDNA clones in your preferred vector: USP54 (NM_152586)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP54
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP54

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    GenScript Custom overexpressing Cell Line Services for USP54
    Search LifeMap BioReagents cell lines for USP54
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP54


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USP54 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP54
        Ubiquitin-Proteasome Dependent Proteolysis


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP54

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/17 Interacting proteins for USP54 (Q70EL11, 2, 3 ENSP000003452164) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542531, 3, ENSP000002447694EBI-946185,EBI-930964 I2D: score=2 STRING: ENSP00000244769
    CHMP1AQ9HD422, 3, ENSP000002534754MINT-6946930 I2D: score=1 STRING: ENSP00000253475
    CHMP2AO436332, 3, ENSP000003104404MINT-6947279 I2D: score=1 STRING: ENSP00000310440
    CHMP4AQ9BY432, 3, ENSP000003242054MINT-6947321 I2D: score=1 STRING: ENSP00000324205
    CHMP4BQ9H4442, 3, ENSP000002174024MINT-6947335 I2D: score=1 STRING: ENSP00000217402
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--

    USP54 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP54 (UBP54)

    Search CenterWatch for drugs/clinical trials and news about USP54 / UBP54

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP54 gene: 
    NM_152586.3  

    Unigene Cluster for USP54:

    Ubiquitin specific peptidase 54
    Hs.657355  [show with all ESTs]
    Unigene Representative Sequence: NM_152586
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000418501 ENST00000466048 ENST00000424265(uc001jul.3) ENST00000339859(uc010qkk.2 uc001juk.3 uc001jum.3 uc001jun.3 uc001juo.3)
    ENST00000497106 ENST00000464635 ENST00000498143(uc001jup.3) ENST00000480210
    ENST00000461520(uc001juq.1) ENST00000451492 ENST00000492357 ENST00000481991
    ENST00000413442 ENST00000433394 ENST00000498213 ENST00000474929 ENST00000408019
    ENST00000428547

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP54
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate USP54 (see all 31):
    hsa-miR-345 hsa-miR-4307 hsa-miR-3152-3p hsa-miR-607 hsa-miR-520d-5p hsa-miR-106a hsa-miR-1285 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidUSP54 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP54
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP54
    Clone
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    OriGene ORF clones in mouse, rat for USP54
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP54 (NM_152586)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP54
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP54
    Primer
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    OriGene qPCR primer pairs and template standards for USP54
    OriGene qSTAR qPCR primer pairs in human, mouse for USP54
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP54
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP54
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP54

    Additional mRNA sequence: 

    AK094637.1 AK123711.1 AK126497.1 AK127213.1 AK127267.1 AK302598.1 AK303633.1 AL832102.1 
    BC026037.1 BC064967.1 BC110845.1 BC130633.1 BX649087.1 

    12 DOTS entries:

    DT.204224  DT.100024157  DT.95295364  DT.100024156  DT.100657930  DT.95250633  DT.40128157  DT.91997313 
    DT.95094209  DT.97827066  DT.40263243  DT.121289482 

    24/83 AceView cDNA sequences (see all 83):

    NM_152586 BU507701 AA806114 BE301605 BQ677504 AK126497 BF001677 AJ583820 
    BG060078 BG995241 AK123711 BQ709847 AW501401 AK127267 AK094637 BQ877017 
    AI249498 AK127213 BC064967 BQ081855 BC026037 CD637891 BU509077 BQ081847 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for USP54 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a ·
    SP1:                                                                                      -                                   -                                 
    SP2:                                                                                      -                                   -                             -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:              -                                                                                                                                             

    ExUns: 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b · 24c
    SP1:                                                                                    
    SP2:  -     -                                         -     -                           
    SP3:                                                                                    
    SP4:                                                  -                                 
    SP5:                                                                                    


    ECgene alternative splicing isoforms for USP54

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP54 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    USP54 Expression
    About this image


    See USP54 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP54

    SOURCE GeneReport for Unigene cluster: Hs.657355

    UniProtKB/Swiss-Prot: UBP54_HUMAN, Q70EL1
    Tissue specificity: Weakly expressed in a few tissues

        SABiosciences Custom PCR Arrays for USP54
    Primer
    Products:
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP54
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP54

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for USP54 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp541 , 5 ubiquitin specific peptidase 541, 5 84.25(n)1
    80.41(a)1
      14 (11.53 cM)5
    787871  NM_030180.21  NP_084456.21 
     205489125 
    chicken
    (Gallus gallus)
    Aves USP541 ubiquitin specific peptidase 54 67.76(n)
    64.17(a)
      423746  XM_421621.3  XP_421621.3 
    lizard
    (Anolis carolinensis)
    Reptilia USP546
    ubiquitin specific peptidase 54
    58(a)
    1 ↔ 1
    GL343196.1(917664-1004669)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005356991 inactive ubiquitin carboxyl-terminal hydrolase 54-like 65(n)
    67.28(a)
      100535699  XM_003199611.1  XP_003199659.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ec6
    echinus
    13(a)
    1 → many
    X(3705684-3751658)


    ENSEMBL Gene Tree for USP54 (if available)
    TreeFam Gene Tree for USP54 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP54 gene
    USP532  
    1 SIMAP similar gene for USP54 using alignment to 6 protein entries:     UBP54_HUMAN (see all proteins):
    USP53

    USP54 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1544 SNPs in USP54 are shown (see all 1544)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363604
    A breast cancer sample4--see VAR_0363602 L V mis40--------
    rs1821023211,2
    --75258008(+) ACCAAC/TGCTGC 1 -- ut310--------
    rs586627991,2
    C,F--75258057(+) TGAGAG/TGGAGT 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1425824941,2
    --75258129(+) CCCGGA/GTTCAA 1 -- ut310--------
    rs1862340441,2
    --75258190(+) CGTCAC/TGCCTG 1 -- ut310--------
    rs29901391,2
    C--75258323(+) cactgC/Tgcccg 1 -- ut310--------
    rs2009915131,2
    C--75258340(+) AGTACA/GGTTTT 1 -- ut310--------
    rs1427659621,2
    C,F--75258428(+) CTGCTC/GTCTTC 2 Q E mis12Minor allele frequency- G:0.00NA EU 5873
    rs413150121,2
    C,F--75258437(+) TCTGGG/AAGCAT 2 /P /S mis12Minor allele frequency- A:0.00NA EU 5873
    rs1174297931,2
    C,F--75258443(+) AGCATC/TTGATA 2 N D mis12Minor allele frequency- T:0.00NA EU 5873

    HapMap Linkage Disequilibrium report for USP54 (75257296 - 75385711 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for USP54:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2430194CNV Deletion19546169

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for USP54:    About MalaCards
    alzheimer's disease    


    USP54 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): USP54
    Human Genome Epidemiology (HuGE) Navigator: USP54 (1 document)

    Export disorders for USP54 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP54 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with USP54)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2, 3 Quesada V.... Lopez-Otin C. (2004)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    5. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Ab initio protein modelling reveals novel human MIT do mains. (PubMed id 19302785)1 Rigden D.J....Clague M.J. (2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 159195 HGNC: 23513 AceView: USP54 Ensembl:ENSG00000166348 euGenes: HUgn159195
    ECgene: USP54 H-InvDB: USP54

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP54 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP54 gene:
    Search GeneIP for patents involving USP54

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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