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Aliases for USP54 Gene

Aliases for USP54 Gene

  • Ubiquitin Specific Peptidase 54 2 3
  • Inactive Ubiquitin-Specific Peptidase 54 3 4
  • Ubiquitin Specific Protease 54 2 3
  • C10orf29 3 4
  • Inactive Ubiquitin Carboxyl-Terminal Hydrolase 54 3
  • Chromosome 10 Open Reading Frame 29 2
  • Ubiquitin Specific Proteinase 54 3
  • BA137L10.3 3
  • BA137L10.4 3

External Ids for USP54 Gene

Previous HGNC Symbols for USP54 Gene

  • C10orf29

Previous GeneCards Identifiers for USP54 Gene

  • GC10M074601
  • GC10M074602
  • GC10M074927
  • GC10M075257
  • GC10M069250

Summaries for USP54 Gene

GeneCards Summary for USP54 Gene

USP54 (Ubiquitin Specific Peptidase 54) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include ubiquitin thiolesterase activity. An important paralog of this gene is USP53.

UniProtKB/Swiss-Prot for USP54 Gene

  • Has no peptidase activity

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP54 Gene

Genomics for USP54 Gene

Regulatory Elements for USP54 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for USP54 Gene

73,497,538 bp from pter
73,625,953 bp from pter
128,416 bases
Minus strand

Genomic View for USP54 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP54 Gene

Proteins for USP54 Gene

  • Protein details for USP54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive ubiquitin carboxyl-terminal hydrolase 54
    Protein Accession:
    Secondary Accessions:
    • A1L4Q4
    • A3KFK3
    • A3KFK5
    • A3KFK6
    • A3KFK7
    • A6PVS4
    • A6PVS5
    • A6PVS6
    • A6PVS7
    • B3KVY1
    • B9ZVM1
    • Q5F2F4
    • Q6P1N6
    • Q6ZSP1
    • Q6ZSR1
    • Q6ZTM0
    • Q8N1X2

    Protein attributes for USP54 Gene

    1684 amino acids
    Molecular mass:
    187388 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04393.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG53943.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BX649087; Type=Frameshift; Positions=508; Evidence={ECO:0000305}; Sequence=CAO03507.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAO03508.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAO03509.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for USP54 Gene

neXtProt entry for USP54 Gene

Proteomics data for USP54 Gene at MOPED

Post-translational modifications for USP54 Gene

  • Ubiquitination at Lys1236
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for USP54 Gene

Domains for USP54 Gene

Gene Families for USP54 Gene

Protein Domains for USP54 Gene

Suggested Antigen Peptide Sequences for USP54 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP54: view

Function for USP54 Gene

Molecular function for USP54 Gene

UniProtKB/Swiss-Prot Function:
Has no peptidase activity

Gene Ontology (GO) - Molecular Function for USP54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16713569
GO:0036459 ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP54: view

Phenotypes for USP54 Gene

GenomeRNAi human phenotypes for USP54:
genes like me logo Genes that share phenotypes with USP54: view

Animal Model Products

miRNA for USP54 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP54

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for USP54 Gene

Localization for USP54 Gene

Subcellular locations from

Jensen Localization Image for USP54 Gene COMPARTMENTS Subcellular localization image for USP54 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP54 Gene

Pathways for USP54 Gene

genes like me logo Genes that share pathways with USP54: view

Pathways by source for USP54 Gene

1 Qiagen pathway for USP54 Gene

Gene Ontology (GO) - Biological Process for USP54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with USP54: view

Transcripts for USP54 Gene

Unigene Clusters for USP54 Gene

Ubiquitin specific peptidase 54:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP54

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP54 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a ·
SP1: - -
SP2: - - -
SP5: -
SP6: - -

ExUns: 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b · 24c
SP2: - - - -
SP4: -
SP6: - -
SP7: - - -
SP10: -

Relevant External Links for USP54 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP54 Gene

mRNA expression in normal human tissues for USP54 Gene

mRNA differential expression in normal tissues according to GTEx for USP54 Gene

This gene is overexpressed in Muscle - Skeletal (7.3).

Protein differential expression in normal tissues for USP54 Gene

This gene is overexpressed in Prostate (30.7), Frontal cortex (28.7), and Spinal cord (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP54 Gene

SOURCE GeneReport for Unigene cluster for USP54 Gene Hs.657355

mRNA Expression by UniProt/SwissProt for USP54 Gene

Tissue specificity: Weakly expressed in a few tissues.
genes like me logo Genes that share expressions with USP54: view

Expression partners for USP54 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for USP54 Gene

Orthologs for USP54 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP54 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia USP54 35
  • 89.62 (n)
  • 86.06 (a)
USP54 36
  • 86 (a)
(Canis familiaris)
Mammalia USP54 35
  • 90.48 (n)
  • 87.75 (a)
USP54 36
  • 87 (a)
(Mus musculus)
Mammalia Usp54 35
  • 83.75 (n)
  • 79.52 (a)
Usp54 16
Usp54 36
  • 80 (a)
(Pan troglodytes)
Mammalia USP54 35
  • 98.79 (n)
  • 98.47 (a)
USP54 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Usp54 35
  • 83.09 (n)
  • 79.58 (a)
(Monodelphis domestica)
Mammalia USP54 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia USP54 36
  • 62 (a)
(Gallus gallus)
Aves USP54 35
  • 67.65 (n)
  • 63.47 (a)
USP54 36
  • 59 (a)
(Anolis carolinensis)
Reptilia USP54 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia usp54 35
  • 61.45 (n)
  • 57.57 (a)
(Danio rerio)
Actinopterygii usp54a 35
  • 65.98 (n)
  • 67.49 (a)
USP54 (1 of 2) 36
  • 49 (a)
usp54a 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta ec 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
Species with no ortholog for USP54:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP54 Gene

Gene Tree for USP54 (if available)
Gene Tree for USP54 (if available)

Paralogs for USP54 Gene

Paralogs for USP54 Gene

(1) SIMAP similar genes for USP54 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with USP54: view

Variants for USP54 Gene

Sequence variations from dbSNP and Humsavar for USP54 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs594617 -- 73,528,458(+) tcacc(A/G)tgtag intron-variant
rs1007496 -- 73,585,373(-) tgctt(A/C)ccata intron-variant
rs1538772 -- 73,555,465(-) CATAG(C/G)TGGTA intron-variant
rs1618542 - 73,517,500(+) TGCTT(C/T)AGGTA reference, missense, downstream-variant-500B, nc-transcript-variant
rs1724076 -- 73,523,092(+) GAAGT(A/G)AAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP54 Gene

Variant ID Type Subtype PubMed ID
esv2430194 CNV Deletion 19546169

Relevant External Links for USP54 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP54 Gene

Disorders for USP54 Gene

Relevant External Links for USP54

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for USP54 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for USP54 Gene

Publications for USP54 Gene

  1. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3

Products for USP54 Gene

Sources for USP54 Gene

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