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Aliases for USP54 Gene

Aliases for USP54 Gene

  • Ubiquitin Specific Peptidase 54 2 3 5
  • Inactive Ubiquitin-Specific Peptidase 54 3 4
  • Ubiquitin Specific Protease 54 2 3
  • C10orf29 3 4
  • Chromosome 10 Open Reading Frame 29 2
  • Ubiquitin Specific Proteinase 54 3
  • BA137L10.3 3
  • BA137L10.4 3

External Ids for USP54 Gene

Previous HGNC Symbols for USP54 Gene

  • C10orf29

Previous GeneCards Identifiers for USP54 Gene

  • GC10M074601
  • GC10M074602
  • GC10M074927
  • GC10M075257
  • GC10M069250

Summaries for USP54 Gene

GeneCards Summary for USP54 Gene

USP54 (Ubiquitin Specific Peptidase 54) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP53.

UniProtKB/Swiss-Prot for USP54 Gene

  • Has no peptidase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP54 Gene

Genomics for USP54 Gene

Regulatory Elements for USP54 Gene

Enhancers for USP54 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around USP54 on UCSC Golden Path with GeneCards custom track

Promoters for USP54 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around USP54 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP54 Gene

Chromosome:
10
Start:
73,497,538 bp from pter
End:
73,625,953 bp from pter
Size:
128,416 bases
Orientation:
Minus strand

Genomic View for USP54 Gene

Genes around USP54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP54 Gene

Proteins for USP54 Gene

  • Protein details for USP54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70EL1-UBP54_HUMAN
    Recommended name:
    Inactive ubiquitin carboxyl-terminal hydrolase 54
    Protein Accession:
    Q70EL1
    Secondary Accessions:
    • A1L4Q4
    • A3KFK3
    • A3KFK5
    • A3KFK6
    • A3KFK7
    • A6PVS4
    • A6PVS5
    • A6PVS6
    • A6PVS7
    • B3KVY1
    • B9ZVM1
    • Q5F2F4
    • Q6P1N6
    • Q6ZSP1
    • Q6ZSR1
    • Q6ZTM0
    • Q8N1X2

    Protein attributes for USP54 Gene

    Size:
    1684 amino acids
    Molecular mass:
    187388 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04393.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG53943.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BX649087; Type=Frameshift; Positions=508; Evidence={ECO:0000305}; Sequence=CAO03507.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAO03508.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAO03509.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for USP54 Gene

neXtProt entry for USP54 Gene

Proteomics data for USP54 Gene at MOPED

Post-translational modifications for USP54 Gene

  • Ubiquitination at Lys 1236
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for USP54 Gene

Domains & Families for USP54 Gene

Gene Families for USP54 Gene

Protein Domains for USP54 Gene

Suggested Antigen Peptide Sequences for USP54 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q70EL1

UniProtKB/Swiss-Prot:

UBP54_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP54: view

Function for USP54 Gene

Molecular function for USP54 Gene

UniProtKB/Swiss-Prot Function:
Has no peptidase activity.

Gene Ontology (GO) - Molecular Function for USP54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP54: view
genes like me logo Genes that share phenotypes with USP54: view

Animal Models for USP54 Gene

MGI Knock Outs for USP54:

Animal Model Products

  • Taconic Biosciences Mouse Models for USP54

miRNA for USP54 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP54 Gene

Localization for USP54 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP54 Gene COMPARTMENTS Subcellular localization image for USP54 gene
Compartment Confidence
mitochondrion 3
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP54 Gene

Pathways & Interactions for USP54 Gene

genes like me logo Genes that share pathways with USP54: view

Pathways by source for USP54 Gene

1 Qiagen pathway for USP54 Gene

Gene Ontology (GO) - Biological Process for USP54 Gene

None

No data available for SIGNOR curated interactions for USP54 Gene

Drugs & Compounds for USP54 Gene

No Compound Related Data Available

Transcripts for USP54 Gene

Unigene Clusters for USP54 Gene

Ubiquitin specific peptidase 54:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP54 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a ·
SP1: - -
SP2: - - -
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8:
SP9:
SP10:

ExUns: 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b · 24c
SP1:
SP2: - - - -
SP3:
SP4: -
SP5:
SP6: - -
SP7: - - -
SP8:
SP9:
SP10: -

Relevant External Links for USP54 Gene

GeneLoc Exon Structure for
USP54
ECgene alternative splicing isoforms for
USP54

Expression for USP54 Gene

mRNA expression in normal human tissues for USP54 Gene

mRNA differential expression in normal tissues according to GTEx for USP54 Gene

This gene is overexpressed in Muscle - Skeletal (x7.3).

Protein differential expression in normal tissues from HIPED for USP54 Gene

This gene is overexpressed in Prostate (30.7), Frontal cortex (28.7), and Spinal cord (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP54 Gene



SOURCE GeneReport for Unigene cluster for USP54 Gene Hs.657355

mRNA Expression by UniProt/SwissProt for USP54 Gene

Q70EL1-UBP54_HUMAN
Tissue specificity: Weakly expressed in a few tissues.
genes like me logo Genes that share expression patterns with USP54: view

Protein tissue co-expression partners for USP54 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for USP54 Gene

Orthologs for USP54 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP54 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia USP54 35
  • 89.62 (n)
  • 86.06 (a)
USP54 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP54 35
  • 90.48 (n)
  • 87.75 (a)
USP54 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp54 35
  • 83.75 (n)
  • 79.52 (a)
Usp54 16
Usp54 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia USP54 35
  • 98.79 (n)
  • 98.47 (a)
USP54 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp54 35
  • 83.09 (n)
  • 79.58 (a)
oppossum
(Monodelphis domestica)
Mammalia USP54 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP54 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP54 35
  • 67.65 (n)
  • 63.47 (a)
USP54 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP54 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp54 35
  • 61.45 (n)
  • 57.57 (a)
zebrafish
(Danio rerio)
Actinopterygii usp54a 35
  • 65.98 (n)
  • 67.49 (a)
USP54 (1 of 2) 36
  • 49 (a)
OneToMany
usp54a 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ec 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for USP54:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP54 Gene

ENSEMBL:
Gene Tree for USP54 (if available)
TreeFam:
Gene Tree for USP54 (if available)

Paralogs for USP54 Gene

Paralogs for USP54 Gene

(1) SIMAP similar genes for USP54 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with USP54: view

Variants for USP54 Gene

Sequence variations from dbSNP and Humsavar for USP54 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_036360 A breast cancer sample
rs1618542 - 73,517,500(+) TGCTT(C/T)AGGTA nc-transcript-variant, downstream-variant-500B, reference, missense
rs4619071 - 73,516,735(+) TATGT(C/T)TGGCT nc-transcript-variant, reference, missense
VAR_047260 -
rs1538772 -- 73,555,465(-) CATAG(C/G)TGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP54 Gene

Variant ID Type Subtype PubMed ID
esv2430194 CNV Deletion 19546169

Variation tolerance for USP54 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.80; 66.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP54 Gene

Human Gene Mutation Database (HGMD)
USP54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP54 Gene

Disorders for USP54 Gene

Relevant External Links for USP54

Genetic Association Database (GAD)
USP54
Human Genome Epidemiology (HuGE) Navigator
USP54
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP54

No disorders were found for USP54 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP54 Gene

Publications for USP54 Gene

  1. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 67
  2. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  3. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for USP54 Gene

Sources for USP54 Gene

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