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USP53 Gene

protein-coding   GIFtS: 55
GCID: GC04P120133

Ubiquitin Specific Peptidase 53

(Previous name: ubiquitin specific protease 53)
  See USP53-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 531 2
Ubiquitin Specific Protease 531 2
Inactive Ubiquitin-Specific Peptidase 532 3
Inactive Ubiquitin Carboxyl-Terminal Hydrolase 532
Ubiquitin Specific Proteinase 532
KIAA13503

External Ids:    HGNC: 292551   Entrez Gene: 545322   Ensembl: ENSG000001453907   UniProtKB: Q70EK83   

Export aliases for USP53 gene to outside databases

Previous GC identifers: GC04P120590 GC04P120619 GC04P120518 GC04P120380 GC04P120354 GC04P115855


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for USP53 Gene:
USP53 (ubiquitin specific peptidase 53) is a protein-coding gene. Diseases associated with USP53 include hypertrichosis. GO annotations related to this gene include ubiquitin thiolesterase activity. An important paralog of this gene is USP54.

UniProtKB/Swiss-Prot: UBP53_HUMAN, Q70EK8
Function: Has no peptidase activity

Gene Wiki entry for USP53 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP53 gene promoter:
         CUTL1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Evi-1   c-Ets-1   C/EBPalpha   POU2F1   POU2F1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP53 promoter sequence
   Search Chromatin IP Primers for USP53

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP53


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q26

USP53 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP53 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P120133:  view genomic region     (about GC identifiers)

Start:
120,133,742 bp from pter      End:
120,216,673 bp from pter
Size:
82,932 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBP53_HUMAN, Q70EK8 (See protein sequence)
Recommended Name: Inactive ubiquitin carboxyl-terminal hydrolase 53  
Size: 1073 amino acids; 120806 Da
Caution: Although the active site residues are conserved, lacks the conserved His residue which is normally found
9 residues before the catalytic His
Sequence caution: Sequence=AAH17382.1; Type=Erroneous initiation;
Secondary accessions: Q68DA5 Q8WVQ5 Q9P2J7

Explore the universe of human proteins at neXtProt for USP53: NX_Q70EK8

Explore proteomics data for USP53 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See USP53 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061923.2  
    ENSEMBL proteins: 
     ENSP00000274030   ENSP00000426628   ENSP00000421729   ENSP00000409906  

    USP53 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for USP53
    OriGene Custom MassSpec
    OriGene Custom Protein Services for USP53
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    Novus Biologicals USP53 Protein
    Novus Biologicals USP53 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP53

     
    Search eBioscience for Proteins for USP53 

    USP53 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for USP53
    Cloud-Clone Corp. Antibodies for USP53
    Search ThermoFisher Antibodies for USP53
    LSBio Antibodies in human, mouse, rat for USP53

    USP53 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP53
    Cloud-Clone Corp. CLIAs for USP53
    Search eBioscience for ELISAs for USP53 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    2 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR028889 UCH/PAN2

    Graphical View of Domain Structure for InterPro Entry Q70EK8

    ProtoNet protein and cluster: Q70EK8

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP53_HUMAN, Q70EK8
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP53           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP53_HUMAN, Q70EK8
    Function: Has no peptidase activity

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221NOT ubiquitin thiolesterase activity IDA14715245
         
    Find genes that share ontologies with USP53           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP53
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP53

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP53
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP53

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP53:
    hsa-mir-30b-5p (MIRT023405), hsa-mir-16-5p (MIRT032060)

    Block miRNA regulation of human, mouse, rat USP53 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP53 (see all 39):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-200a hsa-miR-141 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidUSP53 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP53
    Predesigned siRNA for gene silencing in human, mouse, rat USP53

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP53

    Clone
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    OriGene clones in human, mouse for USP53 (see all 6)
    OriGene ORF clones in mouse, rat for USP53
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP53 (NM_019050)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP53
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP53
    Addgene plasmids for USP53 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for USP53
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP53 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP53


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with USP53           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP53 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP53
        Ubiquitin-Proteasome Dependent Proteolysis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP53
    Interactions:

        Search GeneGlobe Interaction Network for USP53

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for USP53 (Q70EK82, 3 ENSP000002740304) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AZGP1P253113, ENSP000002924014I2D: score=2 STRING: ENSP00000292401
    BLMHQ138673, ENSP000002617144I2D: score=2 STRING: ENSP00000261714
    CASP14P319443, ENSP000002217404I2D: score=2 STRING: ENSP00000221740
    CPNE7Q9UBL63, ENSP000002687204I2D: score=2 STRING: ENSP00000268720
    CSTAP010403, ENSP000002644744I2D: score=2 STRING: ENSP00000264474
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0008150biological_process ND--

    Find genes that share ontologies with USP53           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP53 (UBP53)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP53 gene: 
    NM_019050.2  

    Unigene Clusters for USP53:

    Ubiquitin specific peptidase 53
    Hs.431081  [show with all ESTs], Hs.595368  [show with all ESTs]
    Unigene Representative Sequences: NM_019050, BX113891
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514665 ENST00000274030 ENST00000507597 ENST00000514305 ENST00000510737
    ENST00000509769 ENST00000507906 ENST00000510852(uc003ict.3) ENST00000450251(uc003ics.4 uc003icr.4 uc003icu.4)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP53 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP53 (see all 39):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-200a hsa-miR-141 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidUSP53 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for USP53
    Predesigned siRNA for gene silencing in human, mouse, rat USP53
    Clone
    Products:
         
    OriGene clones in human, mouse for USP53 (see all 6)
    OriGene ORF clones in mouse, rat for USP53
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP53 (NM_019050)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP53
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP53
    Addgene plasmids for USP53 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for USP53
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP53
      QuantiTect SYBR Green Assays in human, mouse, rat USP53
      QuantiFast Probe-based Assays in human, mouse, rat USP53

    Additional mRNA sequence: AF085848.1 

    14 DOTS entries:

    DT.111329  DT.306580  DT.92018936  DT.70104947  DT.97773968  DT.70101570  DT.121219552  DT.100711131 
    DT.121219505  DT.75137146  DT.91808629  DT.100672396  DT.100677745  DT.91951234 

    Selected AceView cDNA sequences (see all 124):

    AB037771 AA319736 CD244970 AI567034 R70063 AI382521 AA653470 BX095809 
    AI276062 BM699374 AJ583824 AI918463 AA398081 BM978590 AW264205 BQ694947 
    AA299360 AA394189 BX648339 BM670031 BX496884 BQ019723 BM983658 BU568370 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for USP53    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                                  
    SP2:                                -           -                     
    SP3:                                            -                     
    SP4:                                                  -               


    ECgene alternative splicing isoforms for USP53

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP53 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAATCAAT
    USP53 Expression
    About this image


    USP53 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Brain (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
    USP53 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP53 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.431081 Hs.595368

    UniProtKB/Swiss-Prot: UBP53_HUMAN, Q70EK8
    Tissue specificity: Expressed predominantly in skeletal muscle and heart

        Custom PCR Arrays for USP53
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    QuantiFast Probe-based Assays in human, mouse, rat USP53
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP53

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for USP53 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp531 , 5 ubiquitin specific peptidase 531, 5 81.46(n)1
    76.76(a)1
      3 (53.75 cM)5
    995261  NM_133857.31  NP_598618.11 
     1229336015 
    chicken
    (Gallus gallus)
    Aves USP531 ubiquitin specific peptidase 53 69.93(n)
    65.86(a)
      422680  XM_420633.4  XP_420633.4 
    lizard
    (Anolis carolinensis)
    Reptilia USP536
    ubiquitin specific peptidase 53
    55(a)
    1 ↔ 1
    5(140044741-140072838)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.327552 Xenopus laevis transcribed sequences 77.52(n)    BJ624799.1 
    zebrafish
    (Danio rerio)
    Actinopterygii USP536
    ubiquitin specific peptidase 53
    78(a)
    1 ↔ 1
    7(72489000-72511552) ENSDARG00000078615
    fruit fly
    (Drosophila melanogaster)
    Insecta ec6
    echinus
    11(a)
    1 → many
    X(3705684-3751658)


    ENSEMBL Gene Tree for USP53 (if available)
    TreeFam Gene Tree for USP53 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP53 gene
    USP542  
    1 SIMAP similar gene for USP53 using alignment to 4 protein entries:     UBP53_HUMAN (see all proteins):
    USP54

    Find genes that share paralogs with USP53           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for USP53
    PGOHUM00000238262


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP53 (see all 1547)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs669909491,2
    C--115934440(+) CTGAT-/CTG   
      T
    /TGTC
    TGTTT
    1 -- int11NA 2
    rs170499721,2
    C,F,H--120131909(+) ATGGCG/AATGAG 1 -- us2k19Minor allele frequency- A:0.03NA NS EA CSA WA 680
    rs119352951,2
    C,F,H--120131951(+) GTGGGT/CAATGA 1 -- us2k15Minor allele frequency- C:0.04NS EA WA 538
    rs1434774121,2
    --120131974(+) AGAGAA/GGTATA 1 -- us2k10--------
    rs1480059501,2
    C--120132012(+) TATTAA/GTAGAA 1 -- us2k10--------
    rs1842990741,2
    --120132071(+) TTGCAA/GTAGTA 1 -- us2k10--------
    rs1885459251,2
    --120132119(+) AGGACC/TAAGAC 1 -- us2k10--------
    rs13976121,2
    C,F,A,H--120132145(-) CTCAGA/GTCCAC 1 -- us2k116Minor allele frequency- G:0.04NS EA NA WA CSA 793
    rs726737841,2
    C,F--120132185(+) TGATAT/CTAGAA 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs22030391,2
    C,F,O,A,H--120132347(-) AATTGA/GCATGG 1 -- us2k127Minor allele frequency- N:0.00NS EA NA WA CSA 2555

    HapMap Linkage Disequilibrium report for USP53 (120133742 - 120216673 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for USP53:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2329745CNV Deletion18987734
    esv2728233CNV Deletion23290073

    Human Gene Mutation Database (HGMD): USP53
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing USP53
    DNA2.0 Custom Variant and Variant Library Synthesis for USP53

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for USP53:    
    About MalaCards
    hypertrichosis

    1 disease from the University of Copenhagen DISEASES database for USP53:
    Hypertrichosis

    Find genes that share disorders with USP53           About GenesLikeMe

    Genetic Association Database (GAD): USP53
    Human Genome Epidemiology (HuGE) Navigator: USP53 (1 document)

    Export disorders for USP53 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP53 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with USP53)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2, 3 Quesada V.... Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Identification of a candidate gene for astigmatism. (PubMed id 23322567)1 Lopes M.C....Hammond C.J. (amp 2013)
    6. The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability. (PubMed id 23159851)1 Zhang L....Gong F. (Cell Cycle 2012)
    7. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    10. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54532 HGNC: 29255 AceView: USP53 Ensembl:ENSG00000145390 euGenes: HUgn54532
    ECgene: USP53 H-InvDB: USP53

    (According to HUGE)
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    HUGE: KIAA1350

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP53 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP53 gene:
    Search GeneIP for patents involving USP53

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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