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Aliases for USP53 Gene

Aliases for USP53 Gene

  • Ubiquitin Specific Peptidase 53 2 3 5
  • Inactive Ubiquitin-Specific Peptidase 53 4
  • Ubiquitin Specific Protease 53 2
  • KIAA1350 4

External Ids for USP53 Gene

Previous GeneCards Identifiers for USP53 Gene

  • GC04P120590
  • GC04P120619
  • GC04P120518
  • GC04P120380
  • GC04P120354
  • GC04P120133
  • GC04P115855

Summaries for USP53 Gene

GeneCards Summary for USP53 Gene

USP53 (Ubiquitin Specific Peptidase 53) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP54.

UniProtKB/Swiss-Prot for USP53 Gene

  • Has no peptidase activity.

Gene Wiki entry for USP53 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP53 Gene

Genomics for USP53 Gene

Regulatory Elements for USP53 Gene

Enhancers for USP53 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around USP53 on UCSC Golden Path with GeneCards custom track

Promoters for USP53 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around USP53 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP53 Gene

119,212,587 bp from pter
119,295,518 bp from pter
82,932 bases
Plus strand

Genomic View for USP53 Gene

Genes around USP53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP53 Gene

Proteins for USP53 Gene

  • Protein details for USP53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive ubiquitin carboxyl-terminal hydrolase 53
    Protein Accession:
    Secondary Accessions:
    • Q68DA5
    • Q8WVQ5
    • Q9P2J7

    Protein attributes for USP53 Gene

    1073 amino acids
    Molecular mass:
    120806 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH17382.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for USP53 Gene

Proteomics data for USP53 Gene at MOPED

Post-translational modifications for USP53 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP53 Gene

No data available for DME Specific Peptides for USP53 Gene

Domains & Families for USP53 Gene

Gene Families for USP53 Gene

Protein Domains for USP53 Gene

Suggested Antigen Peptide Sequences for USP53 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP53: view

Function for USP53 Gene

Molecular function for USP53 Gene

UniProtKB/Swiss-Prot Function:
Has no peptidase activity.
genes like me logo Genes that share phenotypes with USP53: view

Animal Model Products

  • Taconic Biosciences Mouse Models for USP53

miRNA for USP53 Gene

miRTarBase miRNAs that target USP53

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP53 Gene

Localization for USP53 Gene

Subcellular locations from

Jensen Localization Image for USP53 Gene COMPARTMENTS Subcellular localization image for USP53 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP53 Gene

Pathways & Interactions for USP53 Gene

genes like me logo Genes that share pathways with USP53: view

Pathways by source for USP53 Gene

1 Qiagen pathway for USP53 Gene

Gene Ontology (GO) - Biological Process for USP53 Gene


No data available for SIGNOR curated interactions for USP53 Gene

Drugs & Compounds for USP53 Gene

No Compound Related Data Available

Transcripts for USP53 Gene

Unigene Clusters for USP53 Gene

Ubiquitin specific peptidase 53:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP53 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP2: - -
SP3: -
SP4: -

Relevant External Links for USP53 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP53 Gene

mRNA expression in normal human tissues for USP53 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP53 Gene

This gene is overexpressed in Nerve - Tibial (x7.0).

Protein differential expression in normal tissues from HIPED for USP53 Gene

This gene is overexpressed in Heart (36.1) and Pancreatic juice (32.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP53 Gene

SOURCE GeneReport for Unigene cluster for USP53 Gene Hs.431081

mRNA Expression by UniProt/SwissProt for USP53 Gene

Tissue specificity: Expressed predominantly in skeletal muscle and heart.
genes like me logo Genes that share expression patterns with USP53: view

Protein tissue co-expression partners for USP53 Gene

- Elite partner

Primer Products

Orthologs for USP53 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP53 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia USP53 35
  • 92.72 (n)
  • 96.62 (a)
USP53 36
  • 81 (a)
(Canis familiaris)
Mammalia USP53 35
  • 89.74 (n)
  • 85.35 (a)
USP53 36
  • 83 (a)
(Mus musculus)
Mammalia Usp53 35
  • 81.46 (n)
  • 76.76 (a)
Usp53 16
Usp53 36
  • 75 (a)
(Pan troglodytes)
Mammalia USP53 35
  • 99.38 (n)
  • 99.07 (a)
USP53 36
  • 99 (a)
(Monodelphis domestica)
Mammalia USP53 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia USP53 36
  • 58 (a)
(Gallus gallus)
Aves USP53 35
  • 69.93 (n)
  • 65.86 (a)
USP53 36
  • 59 (a)
(Anolis carolinensis)
Reptilia USP53 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia usp53 35
  • 62.5 (n)
  • 58.89 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32755 35
(Danio rerio)
Actinopterygii USP53 36
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta ec 36
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for USP53:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP53 Gene

Gene Tree for USP53 (if available)
Gene Tree for USP53 (if available)

Paralogs for USP53 Gene

Paralogs for USP53 Gene

(1) SIMAP similar genes for USP53 Gene using alignment to 4 proteins: Pseudogenes for USP53 Gene

genes like me logo Genes that share paralogs with USP53: view

Variants for USP53 Gene

Sequence variations from dbSNP and Humsavar for USP53 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs3749591 - 119,292,875(+) CACAG(G/T)TTAAG downstream-variant-500B, reference, missense
rs1323 -- 119,295,263(-) CAACA(A/T)AAATA utr-variant-3-prime
rs1550 -- 119,237,366(-) CCaca(C/G)gctgn intron-variant
rs1551 -- 119,237,345(-) aggac(A/C)taatg intron-variant
rs1134065 -- 119,217,669(+) GTAGA(A/C/G/T)CAAGG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for USP53 Gene

Variant ID Type Subtype PubMed ID
esv2329745 CNV Deletion 18987734
esv2728233 CNV Deletion 23290073

Variation tolerance for USP53 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.65; 82.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP53 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP53 Gene

Disorders for USP53 Gene

Relevant External Links for USP53

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for USP53 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP53 Gene

Publications for USP53 Gene

  1. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Identification of a candidate gene for astigmatism. (PMID: 23322567) Lopes M.C. … Hammond C.J. (Invest. Ophthalmol. Vis. Sci. 2013) 3
  5. The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability. (PMID: 23159851) Zhang L. … Gong F. (Cell Cycle 2012) 3

Products for USP53 Gene

Sources for USP53 Gene