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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

USP53 Gene

protein-coding GIFtS: 53
GCID: GC04P120133

ubiquitin specific peptidase 53

(Previous name: ubiquitin specific protease 53 )

Explore 3 diseases affiliated with
USP53 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 53¹ ²
Ubiquitin Specific Protease 53¹ ²
KIAA1350¹ ³
Inactive Ubiquitin-Specific Peptidase 53² ³
Inactive Ubiquitin Carboxyl-Terminal Hydrolase 53²
Ubiquitin Specific Proteinase 53²

External Ids:	HGNC: 29255¹	Entrez Gene: 54532²	Ensembl: ENSG00000145390⁷	UniProtKB: Q70EK8³

Export aliases for USP53 gene to outside databases

Previous GC identifers: GC04P120590 GC04P120619 GC04P120518 GC04P120380 GC04P120354 GC04P115855

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: UBP53_HUMAN, Q70EK8

Function: Has no peptidase activity

Gene Wiki entry for USP53

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the USP53 gene promoter:
CUTL1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 Evi-1 c-Ets-1 C/EBPalpha POU2F1 POU2F1a Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: USP53 promoter sequence

Search SABiosciences Chromatin IP Primers for USP53

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP53

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26 Ensembl cytogenetic band: 4q26 HGNC cytogenetic band: 4q26

USP53 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP53 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P120133: view genomic region (about GC identifiers)

Start:	120,133,742 bp from pter	End:	120,216,673 bp from pter
Size:	82,932 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UBP53_HUMAN, Q70EK8 (See protein sequence)

Recommended Name: Inactive ubiquitin carboxyl-terminal hydrolase 53

Size: 1073 amino acids; 120806 Da

Caution: Although the active site residues are conserved, lacks the conserved His residue which is normally found 9

residues before the catalytic His

Sequence caution: Sequence=AAH17382.1; Type=Erroneous initiation;

Secondary accessions: Q68DA5 Q8WVQ5 Q9P2J7

Explore the universe of human proteins at neXtProt for USP53: NX_Q70EK8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q70EK8

USP53 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_061923.2

ENSEMBL proteins:

ENSP00000274030 ENSP00000426628 ENSP00000421729 ENSP00000409906

Human Recombinant Protein Products for USP53:

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	Uscn Proteins for USP53

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

USP53 for ontologies About GeneDecksing

USP53 Antibody Products:

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	Uscn ELISAs and CLIAs for USP53

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

USP53 for domains About GeneDecksing

1 InterPro domain/family:

IPR001394 Peptidase_C19

Graphical View of Domain Structure for InterPro Entry Q70EK8

ProtoNet protein and cluster: Q70EK8

1 Blocks protein family: IPB001394 Ubiquitin thiolesterase

UniProtKB/Swiss-Prot: UBP53_HUMAN, Q70EK8

Similarity: Belongs to the peptidase C19 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: UBP53_HUMAN, Q70EK8

Function: Has no peptidase activity

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004221	NOT ubiquitin thiolesterase activity	IDA	14715245

USP53 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for USP53

miRNA Products:		OriGene 3'-UTR Clone: USP53 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP53
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate USP53 (see all 39):
		hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-200a hsa-miR-141 hsa-miR-372

		SwitchGear 3'UTR luciferase reporter plasmid: USP53 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP53 (see all 7) OriGene shRNA RFP: USP53 OriGene siRNA: USP53
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP53

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitin-Proteasome Dependent Proteolysis

Ubiquitin-Proteasome Dependent Proteolysis

1.00

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP53

Ubiquitin-Proteasome Dependent Proteolysis

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for USP53

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

5/28 Interacting proteins for USP53 (Q70EK8^{2, 3} ENSP00000274030⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AZGP1	P25311³, ENSP00000292401⁴	I2D: score=2 STRING: ENSP00000292401
BLMH	Q13867³, ENSP00000261714⁴	I2D: score=2 STRING: ENSP00000261714
CASP14	P31944³, ENSP00000221740⁴	I2D: score=2 STRING: ENSP00000221740
CPNE7	Q9UBL6³, ENSP00000268720⁴	I2D: score=2 STRING: ENSP00000268720
CSTA	P01040³, ENSP00000264474⁴	I2D: score=2 STRING: ENSP00000264474

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006511	ubiquitin-dependent protein catabolic process	IEA	--
GO:0008150	biological_process	ND	--

USP53 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for USP53
Search CenterWatch for drugs/clinical trials and news about USP53 / UBP53

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for USP53 gene:

NM_019050.2

Unigene Clusters for USP53:

Ubiquitin specific peptidase 53

Hs.431081 [show with all ESTs], Hs.595368 [show with all ESTs]

Unigene Representative Sequences: NM_019050, BX113891

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000514665 ENST00000274030 ENST00000507597 ENST00000514305 ENST00000510737

ENST00000509769 ENST00000507906 ENST00000510852(uc003ict.3) ENST00000450251(uc003ics.4 uc003icr.4 uc003icu.4)

miRNA Products:		OriGene 3'-UTR Clone: USP53 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP53
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate USP53 (see all 39):
		hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-200a hsa-miR-141 hsa-miR-372

		SwitchGear 3'UTR luciferase reporter plasmid: USP53 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP53 (see all 7) OriGene shRNA RFP: USP53 OriGene siRNA: USP53
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP53
		Sirion Biotech Custom design and validation of potent shRNA sequences against USP53

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP53 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP53 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: USP53 (NM_019050)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP53
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP53

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP53

Additional cDNA sequence: AF085848.1

14 DOTS entries:

DT.111329 DT.306580 DT.92018936 DT.70104947 DT.97773968 DT.70101570 DT.121219552 DT.100711131

DT.121219505 DT.75137146 DT.91808629 DT.100672396 DT.100677745 DT.91951234

24/124 AceView cDNA sequences (see all 124):

AA299360 AW264205 AI918463 AI567034 R70063 BM978590 AI276062 BX095809

AI382521 BM670031 AB037771 AA394189 AJ583824 AA319736 BM699374 CD244970

BQ694947 BX648339 AA398081 AA653470 BM968497 AA766091 BU568370 AI470170

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for USP53 About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8a	·	8b
SP1:
SP2:											-				-
SP3:															-
SP4:																	-

ECgene alternative splicing isoforms for USP53

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

USP53 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAATCAAT

About this image

USP53 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Line H7 (WA07) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Nkx2-1 GFP+ cells (Efficient derivation...)

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See USP53 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP53

SOURCE GeneReport for Unigene clusters: Hs.431081 Hs.595368

UniProtKB/Swiss-Prot: UBP53_HUMAN, Q70EK8

Tissue specificity: Expressed predominantly in skeletal muscle and heart

SABiosciences Custom PCR Arrays for USP53

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP53

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for USP53 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	USP53¹	ubiquitin specific peptidase 53	69.31(n) 66.3(a)		422680 XM_420633.3 XP_420633.3
lizard (Anolis carolinensis)	Reptilia	USP53⁶	--	60(a)	1 ↔ 1	5(140047962-140072373)
African clawed frog (Xenopus laevis)	Amphibia	Xl.32755²	Xenopus laevis transcribed sequences	77.52(n)		BJ624799.1
zebrafish (Danio rerio)	Actinopterygii	LOC100537347¹	inactive ubiquitin carboxyl-terminal hydrolase 53-like	60.16(n) 59.47(a)		100537347 XM_003197654.1 XP_003197702.1
fruit fly (Drosophila melanogaster)	Insecta	ec⁶	echinus	10(a)	1 → many	X(3705684-3751658)

ENSEMBL Gene Tree for USP53 (if available)
TreeFam Gene Tree for USP53 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for USP53 gene

USP54²

1 SIMAP similar gene for USP53 using alignment to 4 protein entries: UBP53_HUMAN (see all proteins):

USP54

USP53 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for USP53
PGOHUM00000238262

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17049972^1,2	C,F,H	--	120131909(+)	`ATGGCG/AATGAG`	1	--	us2k¹		9		NA NS EA CSA WA	680
rs11935295^1,2	C,F,H	--	120131951(+)	`GTGGGT/CAATGA`	1	--	us2k¹		5		NS EA WA	538
rs143477412^1,2		--	120131974(+)	`AGAGAA/GGTATA`	1	--	us2k¹		0	--	--	--	--
rs148005950^1,2		--	120132012(+)	`TATTAA/GTAGAA`	1	--	us2k¹		0	--	--	--	--
rs184299074^1,2		--	120132071(+)	`TTGCAA/GTAGTA`	1	--	us2k¹		0	--	--	--	--
rs188545925^1,2		--	120132119(+)	`AGGACC/TAAGAC`	1	--	us2k¹		0	--	--	--	--
rs1397612^1,2	C,F,A,H	--	120132145(-)	`CTCAGA/GTCCAC`	1	--	us2k¹		16		NS EA NA WA CSA	793
rs72673784^1,2	C,F	--	120132185(+)	`TGATAT/CTAGAA`	1	--	us2k¹		1		NA	120
rs2203039^1,2	C,F,O,A,H	--	120132347(-)	`AATTGA/GCATGG`	1	--	us2k¹		27		NS EA NA WA CSA	2555
rs76352192^1,2	C	--	120132520(+)	`AACAGC/GAAAAG`	1	--	us2k¹		2		NA	122

HapMap Linkage Disequilibrium report for USP53 (120133742 - 120216673 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for USP53
1 Indel: 46496
Human Gene Mutation Database (HGMD): USP53

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP53

DNA2.0 Custom Variant and Variant Library Synthesis for USP53

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

USP53 for disorders About GeneDecksing

3 diseases for USP53: About MalaCards

alcohol dependence hypertrichosis alcoholism

1 disease from the University of Copenhagen DISEASES database for USP53:

Hypertrichosis

Human Genome Epidemiology (HuGE) Navigator: USP53 (1 document)

Export disorders for USP53 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for USP53 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with USP53)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)^{1, 2, 3} Quesada V.... Lopez-Otin C. (2004)
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2, 3} Nagase T.... Ohara O. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)¹ Altun M....Kessler B.M. (2011)
A human MAP kinase interactome. (PubMed id 20936779)¹ Bandyopadhyay S....Ideker T. (2010)
A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)¹ Kalsi G....Riley B.P. (2010)
Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)¹ Sowa M.E....Harper J.W. (2009)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54532	HGNC: 29255	AceView: USP53	Ensembl:ENSG00000145390	euGenes: HUgn54532
ECgene: USP53	H-InvDB: USP53

(According to HUGE)
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HUGE: KIAA1350

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for USP53	Pharmacogenomics, SNPs, Pathways

Intellectual Property for USP53 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for USP53 gene:
Search GeneIP for patents involving USP53

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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USP53 Gene

ubiquitin specific peptidase 53

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USP53 Gene

ubiquitin specific peptidase 53

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