Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP53 Gene

protein-coding   GIFtS: 55
GCID: GC04P120133

Ubiquitin Specific Peptidase 53

(Previous name: ubiquitin specific protease 53)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 531 2
Ubiquitin Specific Protease 531 2
Inactive Ubiquitin-Specific Peptidase 532 3
Inactive Ubiquitin Carboxyl-Terminal Hydrolase 532
Ubiquitin Specific Proteinase 532
KIAA13503

External Ids:    HGNC: 292551   Entrez Gene: 545322   Ensembl: ENSG000001453907   UniProtKB: Q70EK83   

Export aliases for USP53 gene to outside databases

Previous GC identifers: GC04P120590 GC04P120619 GC04P120518 GC04P120380 GC04P120354 GC04P115855


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for USP53 Gene: 
USP53 (ubiquitin specific peptidase 53) is a protein-coding gene. Diseases associated with USP53 include hypertrichosis, and alcohol dependence. GO annotations related to this gene include ubiquitin thiolesterase activity. An important paralog of this gene is USP54.

UniProtKB/Swiss-Prot: UBP53_HUMAN, Q70EK8
Function: Has no peptidase activity

Gene Wiki entry for USP53 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP53 gene promoter:
         CUTL1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Evi-1   c-Ets-1   C/EBPalpha   POU2F1   POU2F1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP53 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP53

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP53


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q26

USP53 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP53 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P120133:  view genomic region     (about GC identifiers)

Start:
120,133,742 bp from pter      End:
120,216,673 bp from pter
Size:
82,932 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP53_HUMAN, Q70EK8 (See protein sequence)
Recommended Name: Inactive ubiquitin carboxyl-terminal hydrolase 53  
Size: 1073 amino acids; 120806 Da
Caution: Although the active site residues are conserved, lacks the conserved His residue which is normally found
9 residues before the catalytic His
Sequence caution: Sequence=AAH17382.1; Type=Erroneous initiation;
Secondary accessions: Q68DA5 Q8WVQ5 Q9P2J7

Explore the universe of human proteins at neXtProt for USP53: NX_Q70EK8

Explore proteomics data for USP53 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q70EK8

  • USP53 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP53 Protein Expression
    REFSEQ proteins: NP_061923.2  
    ENSEMBL proteins: 
     ENSP00000274030   ENSP00000426628   ENSP00000421729   ENSP00000409906  

    Human Recombinant Protein Products for USP53: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for USP53
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for USP53
    GenScript Custom Purified and Recombinant Proteins Services for USP53
    Novus Biologicals USP53 Protein
    Novus Biologicals USP53 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP53 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    USP53 for ontologies           About GeneDecksing



    USP53 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for USP53
    GenScript Custom Superior Antibodies Services for USP53
    Novus Biologicals USP53 Antibodies
    Abcam antibodies for USP53
    Cloud-Clone Corp. Antibodies for USP53 
    Search ThermoFisher Antibodies for USP53
    LSBio Antibodies in human, mouse, rat for USP53 

    Assay Products for USP53: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP53
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP53
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP53 
    Cloud-Clone Corp. CLIAs for USP53


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    1 InterPro protein domain:
     IPR001394 Peptidase_C19

    Graphical View of Domain Structure for InterPro Entry Q70EK8

    ProtoNet protein and cluster: Q70EK8

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP53_HUMAN, Q70EK8
    Similarity: Belongs to the peptidase C19 family


    USP53 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP53_HUMAN, Q70EK8
    Function: Has no peptidase activity

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221NOT ubiquitin thiolesterase activity IDA14715245
         
    USP53 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for USP53 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP53

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP53 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP53 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP53
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate USP53 (see all 39):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-200a hsa-miR-141 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidUSP53 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP53
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP53

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP53
    Sirion Biotech Customized adenovirus for overexpression of USP53

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for USP53 (see all 7)
    OriGene ORF clones in mouse, rat for USP53
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP53 (NM_019050)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP53
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP53
    Sirion Biotech Customized lentivirus for stable overexpression of USP53 
                         Customized lentivirus expression plasmids for stable overexpression of USP53 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for USP53
    Search LifeMap BioReagents cell lines for USP53
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP53


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USP53 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP53
        Ubiquitin-Proteasome Dependent Proteolysis


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP53

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/28 Interacting proteins for USP53 (Q70EK82, 3 ENSP000002740304) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AZGP1P253113, ENSP000002924014I2D: score=2 STRING: ENSP00000292401
    BLMHQ138673, ENSP000002617144I2D: score=2 STRING: ENSP00000261714
    CASP14P319443, ENSP000002217404I2D: score=2 STRING: ENSP00000221740
    CPNE7Q9UBL63, ENSP000002687204I2D: score=2 STRING: ENSP00000268720
    CSTAP010403, ENSP000002644744I2D: score=2 STRING: ENSP00000264474
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0008150biological_process ND--

    USP53 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP53 (UBP53)

    Search CenterWatch for drugs/clinical trials and news about USP53 / UBP53

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP53 gene: 
    NM_019050.2  

    Unigene Clusters for USP53:

    Ubiquitin specific peptidase 53
    Hs.431081  [show with all ESTs], Hs.595368  [show with all ESTs]
    Unigene Representative Sequences: NM_019050, BX113891
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514665 ENST00000274030 ENST00000507597 ENST00000514305 ENST00000510737
    ENST00000509769 ENST00000507906 ENST00000510852(uc003ict.3) ENST00000450251(uc003ics.4 uc003icr.4 uc003icu.4)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP53
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate USP53 (see all 39):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-200a hsa-miR-141 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidUSP53 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP53
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP53
    Clone
    Products:
         
    OriGene clones in human, mouse for USP53 (see all 7)
    OriGene ORF clones in mouse, rat for USP53
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP53 (NM_019050)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP53
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP53
    Sirion Biotech Customized lentivirus for stable overexpression of USP53 
                         Customized lentivirus expression plasmids for stable overexpression of USP53 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for USP53
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP53
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP53
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP53

    Additional mRNA sequence: AF085848.1 

    14 DOTS entries:

    DT.111329  DT.306580  DT.92018936  DT.70104947  DT.97773968  DT.70101570  DT.121219552  DT.100711131 
    DT.121219505  DT.75137146  DT.91808629  DT.100672396  DT.100677745  DT.91951234 

    24/124 AceView cDNA sequences (see all 124):

    BM699374 AI567034 BM978590 AA394189 AI382521 BX648339 AJ583824 AA319736 
    AA653470 AB037771 BM670031 AA398081 AI276062 AW264205 R70063 AA299360 
    BQ694947 BX095809 AI918463 CD244970 BV205689 BC062741 AF085848 AI073633 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for USP53    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                                  
    SP2:                                -           -                     
    SP3:                                            -                     
    SP4:                                                  -               


    ECgene alternative splicing isoforms for USP53

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP53 expression in normal human tissues (normalized intensities)      USP53 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAATCAAT
    USP53 Expression
    About this image


    USP53 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             visceral organ/oral region/upper jaw   
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H7 (WA07)

    See USP53 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP53

    SOURCE GeneReport for Unigene clusters: Hs.431081 Hs.595368

    UniProtKB/Swiss-Prot: UBP53_HUMAN, Q70EK8
    Tissue specificity: Expressed predominantly in skeletal muscle and heart

        SABiosciences Custom PCR Arrays for USP53
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for USP53
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP53
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP53
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP53
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP53

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for USP53 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp531 , 5 ubiquitin specific peptidase 531, 5 81.49(n)1
    76.76(a)1
      3 (53.75 cM)5
    995261  NM_133857.31  NP_598618.11 
     1229336015 
    chicken
    (Gallus gallus)
    Aves USP531 ubiquitin specific peptidase 53 69.31(n)
    66.3(a)
      422680  XM_420633.3  XP_420633.3 
    lizard
    (Anolis carolinensis)
    Reptilia USP536
    ubiquitin specific peptidase 53
    57(a)
    1 ↔ 1
    5(140044741-140072838)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.327552 Xenopus laevis transcribed sequences 77.52(n)    BJ624799.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005373471 inactive ubiquitin carboxyl-terminal hydrolase 53-like 60.16(n)
    59.47(a)
      100537347  XM_003197654.1  XP_003197702.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ec6
    echinus
    9(a)
    1 → many
    X(3705684-3751658)


    ENSEMBL Gene Tree for USP53 (if available)
    TreeFam Gene Tree for USP53 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP53 gene
    USP542  
    1 SIMAP similar gene for USP53 using alignment to 4 protein entries:     UBP53_HUMAN (see all proteins):
    USP54

    USP53 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for USP53
    PGOHUM00000238262


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1547 SNPs in USP53 are shown (see all 1547)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs669909491,2
    C--115934440(+) CTGAT-/CTG   
      T
    /TGTC
    TGTTT
    1 -- int11NA 2
    rs170499721,2
    C,F,H--120131909(+) ATGGCG/AATGAG 1 -- us2k19Minor allele frequency- A:0.03NA NS EA CSA WA 680
    rs119352951,2
    C,F,H--120131951(+) GTGGGT/CAATGA 1 -- us2k15Minor allele frequency- C:0.04NS EA WA 538
    rs1434774121,2
    --120131974(+) AGAGAA/GGTATA 1 -- us2k10--------
    rs1480059501,2
    C--120132012(+) TATTAA/GTAGAA 1 -- us2k10--------
    rs1842990741,2
    --120132071(+) TTGCAA/GTAGTA 1 -- us2k10--------
    rs1885459251,2
    --120132119(+) AGGACC/TAAGAC 1 -- us2k10--------
    rs13976121,2
    C,F,A,H--120132145(-) CTCAGA/GTCCAC 1 -- us2k116Minor allele frequency- G:0.04NS EA NA WA CSA 793
    rs726737841,2
    C,F--120132185(+) TGATAT/CTAGAA 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs22030391,2
    C,F,O,A,H--120132347(-) AATTGA/GCATGG 1 -- us2k127Minor allele frequency- N:0.00NS EA NA WA CSA 2555

    HapMap Linkage Disequilibrium report for USP53 (120133742 - 120216673 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for USP53:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2329745CNV Deletion18987734
    esv2728233CNV Deletion23290073


    Human Gene Mutation Database (HGMD): USP53
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing USP53
    DNA2.0 Custom Variant and Variant Library Synthesis for USP53

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for USP53:    About MalaCards
    hypertrichosis    alcohol dependence    alcoholism

    1 disease from the University of Copenhagen DISEASES database for USP53:
    Hypertrichosis

    USP53 for disorders           About GeneDecksing

    Genetic Association Database (GAD): USP53
    Human Genome Epidemiology (HuGE) Navigator: USP53 (1 document)

    Export disorders for USP53 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP53 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with USP53)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2, 3 Quesada V.... Lopez-Otin C. (2004)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Identification of a candidate gene for astigmatism. (PubMed id 23322567)1 Lopes M.C....Hammond C.J. (2013)
    6. The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability. (PubMed id 23159851)1 Zhang L....Gong F. (2012)
    7. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
    8. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    9. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    10. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54532 HGNC: 29255 AceView: USP53 Ensembl:ENSG00000145390 euGenes: HUgn54532
    ECgene: USP53 H-InvDB: USP53

    (According to HUGE)
    About This Section
    HUGE: KIAA1350

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP53 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP53 gene:
    Search GeneIP for patents involving USP53

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for USP53  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for USP53  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for USP53  
     OriGene qSTAR qPCR primer pairs in human, mouse for USP53   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for USP53   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for USP53   OriGene Custom Protein Services for USP53  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP53
     QIAGEN SeqTarget long-range PCR primers for resequencing USP53
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP53
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP53
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP53
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP53
     GenScript Custom Purified and Recombinant Proteins Services for USP53 GenScript cDNA clones with any tag delivered in your preferred vector for USP53
     GenScript Custom Assay Services for USP53 GenScript Custom Superior Antibodies Services for USP53
     GenScript Custom overexpressing Cell Line Services for USP53 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in USP53 promoter
     Search Chromatin IP Primers for USP53
     RT2 qPCR Primer Assay in human, mouse, rat USP53
     Search GNC Networks for USP53
     SABiosciences PCR Arrays including human, mouse, rat USP53
     Search Tocris compounds for USP53 (UBP53)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     USP53 antibodies
     USP53 proteins
     USP53 lysates
     Antibodies for USP53
     See all of Abcam's Antibodies, Kits and Proteins for USP53
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for USP53
     Antibodies for USP53
     ELISAs for USP53
     CLIAs for USP53
     Search LifeMap BioReagents cell lines for USP53
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP53
     SwitchGear 3'UTR luciferase reporter plasmids for USP53
     SwitchGear Promoter luciferase reporter plasmids for USP53
     Search ThermoFisher Antibodies for USP53
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP53
     inGenious Targeting Laboratory - Custom generated mouse model solutions for USP53
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP53
    Customized:
     lentivirus for stable overexpression of USP53
     lentivirus expression plasmids for stable overexpression of USP53
     adenovirus for overexpression of USP53
     LSBio Antibodies in human, mouse, rat for USP53
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      USP53 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4