USP51 Gene
protein-coding GIFtS: 46
GCID: GC0XM055511
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|
ubiquitin specific peptidase 51(Previous name: ubiquitin specific protease 51 )
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Aliases
for USP51 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 511 2 | | Ubiquitin Carboxyl-Terminal Hydrolase 512 | | Deubiquitinating Enzyme 512 3 | | Ubiquitin Thiolesterase 512 | | Ubiquitin Thioesterase 512 3 | | EC 3.4.19.123 | | Ubiquitin-Specific-Processing Protease 512 3 | | EC 3.1.2.158 | | Ubiquitin Specific Protease 511 | | |
Export aliases for USP51 gene to outside databasesPrevious GC identifers: GC0XU900509 GC0XM054480 GC0XM055396 GC0XM055529 GC0XM052562 |
Summaries
for USP51 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for USP51
|
Genomic Views
for USP51 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011630.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP51 gene promoter:
Sp1 FOXF2 POU3F1 p300 Lmo2 GATA-1 YY1 POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP51
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP51 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.21 Ensembl cytogenetic band: Xp11.21 HGNC cytogenetic band: Xp11USP51 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM055511: view genomic region
(about GC identifiers)
Start:
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55,511,049 bp from pter |
End:
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55,515,635 bp from pter |
Size:
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4,587 bases |
Orientation:
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minus strand |
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Proteins
for USP51 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP51_HUMAN, Q70EK9 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 51 Size: 711 amino acids; 79756 Da
Sequence caution: Sequence=AAH35907.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence;
Secondary accessions: Q8IWJ8Explore the universe of human proteins at neXtProt for USP51: NX_Q70EK9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q70EK9
4/12 DME Specific Peptides for USP51 (Q70EK9) (see all 12)
USP51 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_958443.1
ENSEMBL proteins: ENSP00000423333
Human Recombinant Protein Products:
USP51 Antibody Products:
Assay Products for USP51: |
Protein
Domains /
Families
for USP51 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP51 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q70EK9ProtoNet protein and cluster: Q70EK9 2 Blocks protein families: IPB001394 Ubiquitin thiolesterase IPB001607 Zn-finger in ubiquitin thiolesterase
UniProtKB/Swiss-Prot: UBP51_HUMAN, Q70EK9Similarity: Belongs to the peptidase C19 familySimilarity: Contains 1 UBP-type zinc finger |
Function
for USP51 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBP51_HUMAN, Q70EK9Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP51 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP51
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: USP51 (NM_201286) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP51 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP51 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP51 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004221 | ubiquitin thiolesterase activity |
IEA | -- | | GO:0008234 | cysteine-type peptidase activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
USP51 for ontologies About GeneDecksing
|
Pathways & Interactions
for USP51 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitin-Proteasome Dependent Proteolysis | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP51
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP51
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- |
USP51 for ontologies About GeneDecksing
|
Drugs & Compounds
for USP51 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USP51
1 HMDB Compound for USP51 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Water | Dihydrogen oxide (see all 2) | 7732-18-5 | -- |
Search CenterWatch for drugs/clinical trials and news about USP51 / UBP51
|
Transcripts
for USP51 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP51 gene: NM_201286.3 Unigene Cluster for USP51: Ubiquitin specific peptidase 51 Hs.40061 [show with all ESTs]Unigene Representative Sequence: NM_2012862 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000500968(uc004dun.2) ENST00000586165
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP51 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP51
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: USP51 (NM_201286) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP51 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP51 |
Additional cDNA sequence: AJ583823.2 BC035907.1 BC131541.1 4 DOTS entries: DT.100653285 DT.107712 DT.121323386 DT.40282146 3 AceView cDNA sequences: BC035907 AA337835 BI856140
GeneLoc Exon Structure
|
Expression
for USP51 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP51 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTAAGGATT
About this image
See USP51 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP51
SOURCE GeneReport for Unigene cluster: Hs.40061
UniProtKB/Swiss-Prot: UBP51_HUMAN, Q70EK9Tissue specificity: Expressed in prostate, brain, lung, aorta and kidney
SABiosciences Custom PCR Arrays for USP51
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP51
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat USP51 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP51 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP51 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP51 |
Orthologs
for USP51 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for USP51 gene from 7/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
F1NG36_CHICK6 |
Ubiquitin carboxyl-terminal hydrolase |
72(a) |
1 ↔ 1 |
14(4611000-4665839) |
lizard
(Anolis carolinensis) |
Reptilia |
USP516 |
-- |
70(a) |
1 ↔ 1 |
GL343385.1(764731-818907) |
zebrafish
(Danio rerio) |
Actinopterygii |
usp226 |
ubiquitin specific peptidase 22 |
71(a) |
1 → many |
12(1670428-1703832) |
fruit fly
(Drosophila melanogaster) |
Insecta |
not6 |
non-stop |
48(a) |
1 → many |
3L(18611906-18615229) |
worm
(Caenorhabditis elegans) |
Secernentea |
T22F3.26 |
Protein T22F3.2, isoform b |
16(a) |
possible ortholog |
V(3586637-3589004) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
UBP221 |
ubiquitin carboxyl-terminal hydrolase 22 |
48.05(n)
37.97(a) |
|
830946 NM_121117.1 NP_568239.1 |
rice
(Oryza sativa) |
Liliopsida |
-- |
ubiquitin carboxyl-terminal hydrolase domain conta... |
36(a) |
1 → many |
4(32748040-32752097) |
ENSEMBL Gene Tree for USP51 (if available)
TreeFam Gene Tree for USP51 (if available) |
Paralogs
for USP51 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP51 gene
- USP332 USP32 USP442 USP452 USP222 USP162 USP492 USP202
4 SIMAP similar genes for USP51 using alignment to 1 protein entry: UBP51_HUMAN:DKFZp434K1822 USP27X USP22 USP15
USP51 for paralogs About GeneDecksing
|
Genomic Variants
for USP51 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP51 (55511049 - 55515635 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for USP51
1 CNV: 23256
2 Inversions: 37384 37385
Locus Specific Mutation Databases (LSDB): USP51
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for USP51 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP51 for disorders About GeneDecksing
1  disease for USP51: About MalaCardsprostatitis
Export disorders for USP51 gene to outside databases
|
Publications
for USP51 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USP51 gene integrated from 9 sources:
(articles sorted by number of sources associating them with USP51) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- A genomic analysis of rat proteases and protease inhibitors. (PubMed id 15060002)1, 2 Puente X.S. and Lopez-Otin C. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (2004)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- A microarray of ubiquitylated proteins for profiling d eubiquitylase activity reveals the critical roles of both chain and substrate. (PubMed id 22626734)1 Loch C.M. and Strickler J.E. (2012)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Bridging expressed sequence alignments through targeted cDNA sequencing. (PubMed id 15028280)1 Xie H....Gill-More R. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
|
External Searches for USP51 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing USP51 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USP51 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing USP51 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for USP51 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for USP51 gene:
Search GeneIP for patents involving USP51
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for USP51 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for USP51 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP51 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP51 | | | OriGene Protein Over-expression Lysate for USP51 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for USP51 | | OriGene 3'-UTR Clone for USP51 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP51 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP51 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for USP51 | | OriGene Custom Protein Services for USP51 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP51 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP51 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP51 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP51 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP51 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP51 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for USP51 |
| |  |  |  |  | | | | |
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 | | | USP51 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP51 |
|  |  |  | | | | Search ThermoFisher Antibodies for USP51 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP51 |
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