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Aliases for USP51 Gene

Aliases for USP51 Gene

  • Ubiquitin Specific Peptidase 51 2 3
  • Ubiquitin-Specific-Processing Protease 51 4
  • Ubiquitin Specific Protease 51 2
  • Deubiquitinating Enzyme 51 4
  • Ubiquitin Thioesterase 51 4
  • EC 4
  • EC 63

External Ids for USP51 Gene

Previous GeneCards Identifiers for USP51 Gene

  • GC0XU900509
  • GC0XM054480
  • GC0XM055396
  • GC0XM055529
  • GC0XM052562

Summaries for USP51 Gene

GeneCards Summary for USP51 Gene

USP51 (Ubiquitin Specific Peptidase 51) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include ubiquitin thiolesterase activity and cysteine-type peptidase activity. An important paralog of this gene is USP36.

Gene Wiki entry for USP51 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP51 Gene

Genomics for USP51 Gene

Regulatory Elements for USP51 Gene

Genomic Location for USP51 Gene

55,484,616 bp from pter
55,489,868 bp from pter
5,253 bases
Minus strand

Genomic View for USP51 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP51 Gene

Proteins for USP51 Gene

  • Protein details for USP51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 51
    Protein Accession:
    Secondary Accessions:
    • Q8IWJ8

    Protein attributes for USP51 Gene

    711 amino acids
    Molecular mass:
    79756 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH35907.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for USP51 Gene

Proteomics data for USP51 Gene at MOPED

Post-translational modifications for USP51 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP51 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for USP51 Gene

Gene Families for USP51 Gene

Suggested Antigen Peptide Sequences for USP51 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 UBP-type zinc finger.
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 UBP-type zinc finger.
genes like me logo Genes that share domains with USP51: view

Function for USP51 Gene

Molecular function for USP51 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme Numbers (IUBMB) for USP51 Gene

Gene Ontology (GO) - Molecular Function for USP51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0004843 ubiquitin-specific protease activity IDA 14715245
GO:0008270 zinc ion binding IEA --
GO:0036459 ubiquitinyl hydrolase activity --
genes like me logo Genes that share ontologies with USP51: view

Animal Model Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP51 Gene

Localization for USP51 Gene

Gene Ontology (GO) - Cellular Components for USP51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IBA --
genes like me logo Genes that share ontologies with USP51: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for USP51 Gene

Pathways for USP51 Gene

genes like me logo Genes that share pathways with USP51: view

Pathways by source for USP51 Gene

1 Qiagen pathway for USP51 Gene

Gene Ontology (GO) - Biological Process for USP51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0016578 histone deubiquitination IBA --
GO:0016579 protein deubiquitination IDA 14715245
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with USP51: view

Drugs for USP51 Gene

(1) HMDB Compounds for USP51 Gene

Compound Synonyms Cas Number PubMed IDs
  • Dihydrogen oxide
genes like me logo Genes that share compounds with USP51: view

Transcripts for USP51 Gene

mRNA/cDNA for USP51 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for USP51 Gene

Ubiquitin specific peptidase 51:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP51

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP51 Gene

No ASD Table

Relevant External Links for USP51 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP51 Gene

mRNA expression in normal human tissues for USP51 Gene

SOURCE GeneReport for Unigene cluster for USP51 Gene Hs.40061

mRNA Expression by UniProt/SwissProt for USP51 Gene

Tissue specificity: Expressed in prostate, brain, lung, aorta and kidney.
genes like me logo Genes that share expressions with USP51: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for USP51 Gene

Orthologs for USP51 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP51 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Usp51 35
  • 81.85 (n)
  • 78.77 (a)
Usp51 16
Usp51 36
  • 77 (a)
(Pan troglodytes)
Mammalia USP51 35
  • 99.77 (n)
  • 99.58 (a)
USP51 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Usp51 35
  • 82.18 (n)
  • 78.76 (a)
(Monodelphis domestica)
Mammalia USP51 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
(Gallus gallus)
Aves -- 36
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
(Danio rerio)
Actinopterygii usp22 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta not 36
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1941 36
  • 50 (a)
Species with no ortholog for USP51:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP51 Gene

Gene Tree for USP51 (if available)
Gene Tree for USP51 (if available)

Paralogs for USP51 Gene

(4) SIMAP similar genes for USP51 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with USP51: view

Variants for USP51 Gene

Sequence variations from dbSNP and Humsavar for USP51 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2499862 -- 55,484,485(+) TCATA(C/T)CCTGC downstream-variant-500B
rs3002630 -- 55,485,881(+) AAACT(C/T)GCCTC utr-variant-3-prime
rs5913836 -- 55,485,516(+) AAAAA(A/T)ATATA utr-variant-3-prime
rs35745013 -- 55,485,518(+) AAATA(A/T)ATATA utr-variant-3-prime
rs73491718 -- 55,484,620(+) CTTCA(C/T)ATTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for USP51 Gene

Variant ID Type Subtype PubMed ID
nsv435891 CNV Deletion 17901297
esv2740175 CNV Deletion 23290073
nsv469510 CNV Complex 16826518
nsv7448 OTHER Inversion 18451855
nsv499493 OTHER Inversion 21111241
nsv524155 CNV Gain 19592680

Relevant External Links for USP51 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP51 Gene

Disorders for USP51 Gene

No disorders were found for USP51 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for USP51 Gene

Publications for USP51 Gene

  1. A genomic analysis of rat proteases and protease inhibitors. (PMID: 15060002) Puente X.S. … Lopez-Otin C. (Genome Res. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  5. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 3 4

Products for USP51 Gene

Sources for USP51 Gene

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