Free for academic non-profit institutions. Other users need a Commercial license

Aliases for USP51 Gene

Aliases for USP51 Gene

  • Ubiquitin Specific Peptidase 51 2 3 5
  • Ubiquitin-Specific-Processing Protease 51 4
  • Ubiquitin Specific Protease 51 2
  • Deubiquitinating Enzyme 51 4
  • Ubiquitin Thioesterase 51 4
  • EC 4
  • EC 58

External Ids for USP51 Gene

Previous GeneCards Identifiers for USP51 Gene

  • GC0XU900509
  • GC0XM054480
  • GC0XM055396
  • GC0XM055529
  • GC0XM052562

Summaries for USP51 Gene

GeneCards Summary for USP51 Gene

USP51 (Ubiquitin Specific Peptidase 51) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP22.

Gene Wiki entry for USP51 Gene

Additional gene information for USP51 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP51 Gene

Genomics for USP51 Gene

Regulatory Elements for USP51 Gene

Enhancers for USP51 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH055488 0.8 ENCODE 0.7 +0.5 541 4.1 ZNF76 SIN3A YY1 EGR1 SCRT2 CREM SP3 SMAD5 REST TFDP1 MAGEH1 KLF8 LOC101928692 USP51
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around USP51 on UCSC Golden Path with GeneCards custom track

Promoters for USP51 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246771 668 2400 BCOR CTCF SIN3A ZNF76 ZMYM3 YY1 E2F1 ZFHX2 POLR2A EGR1

Genomic Locations for USP51 Gene

Genomic Locations for USP51 Gene
5,253 bases
Minus strand

Genomic View for USP51 Gene

Genes around USP51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP51 Gene

Proteins for USP51 Gene

  • Protein details for USP51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 51
    Protein Accession:
    Secondary Accessions:
    • Q8IWJ8

    Protein attributes for USP51 Gene

    711 amino acids
    Molecular mass:
    79756 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH35907.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for USP51 Gene

Selected DME Specific Peptides for USP51 Gene


Post-translational modifications for USP51 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP51 Gene

Domains & Families for USP51 Gene

Gene Families for USP51 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for USP51 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C19 family.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP51: view

Function for USP51 Gene

Molecular function for USP51 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme Numbers (IUBMB) for USP51 Gene

Gene Ontology (GO) - Molecular Function for USP51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 27083998
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 14715245
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with USP51: view
genes like me logo Genes that share phenotypes with USP51: view

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP51 Gene

Localization for USP51 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for USP51 Gene

Pathways & Interactions for USP51 Gene

genes like me logo Genes that share pathways with USP51: view

Pathways by source for USP51 Gene

1 Qiagen pathway for USP51 Gene

Gene Ontology (GO) - Biological Process for USP51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0010564 regulation of cell cycle process IMP 27083998
GO:0010569 regulation of double-strand break repair via homologous recombination IMP 27083998
GO:0016578 histone deubiquitination IMP 27083998
genes like me logo Genes that share ontologies with USP51: view

No data available for SIGNOR curated interactions for USP51 Gene

Drugs & Compounds for USP51 Gene

(1) Drugs for USP51 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with USP51: view

Transcripts for USP51 Gene

mRNA/cDNA for USP51 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for USP51 Gene

Ubiquitin specific peptidase 51:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP51 Gene

No ASD Table

Relevant External Links for USP51 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP51 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP51 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP51 Gene:


SOURCE GeneReport for Unigene cluster for USP51 Gene:


mRNA Expression by UniProt/SwissProt for USP51 Gene:

Tissue specificity: Expressed in prostate, brain, lung, aorta and kidney.
genes like me logo Genes that share expression patterns with USP51: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP51 Gene

Orthologs for USP51 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP51 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia USP51 33 34
  • 99.77 (n)
(Rattus norvegicus)
Mammalia Usp51 33
  • 82.18 (n)
(Mus musculus)
Mammalia Usp51 33 16 34
  • 81.85 (n)
(Monodelphis domestica)
Mammalia USP51 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
(Gallus gallus)
Aves -- 34
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 68 (a)
(Danio rerio)
Actinopterygii usp22 34
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta not 34
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 34
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1941 34
  • 50 (a)
Species where no ortholog for USP51 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP51 Gene

Gene Tree for USP51 (if available)
Gene Tree for USP51 (if available)

Paralogs for USP51 Gene

Variants for USP51 Gene

Sequence variations from dbSNP and Humsavar for USP51 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000090055 -- 55,489,369(+) TCCTA(A/T)AAAAC intron-variant, upstream-variant-2KB
rs1000902230 -- 55,485,031(+) GAGCA(A/G)AAGGA utr-variant-3-prime
rs1001083686 -- 55,486,166(+) TTTAA(G/T)AATTT utr-variant-3-prime
rs1001729477 -- 55,490,714(+) ACGCC(A/C)GGAGA nc-transcript-variant, upstream-variant-2KB
rs1002133142 -- 55,485,271(+) AATAA(C/T)GCAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for USP51 Gene

Variant ID Type Subtype PubMed ID
nsv7448 OTHER inversion 18451855
nsv524155 CNV gain 19592680
nsv499493 OTHER inversion 21111241
nsv469510 CNV gain 16826518
nsv435891 CNV deletion 17901297
esv2740175 CNV deletion 23290073

Variation tolerance for USP51 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP51 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP51 Gene

Disorders for USP51 Gene

Relevant External Links for USP51

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for USP51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP51 Gene

Publications for USP51 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V … López-Otín C (Biochemical and biophysical research communications 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. A genomic analysis of rat proteases and protease inhibitors. (PMID: 15060002) Puente XS … López-Otín C (Genome research 2004) 3 4 60
  5. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3 60

Products for USP51 Gene

Sources for USP51 Gene

Loading form....