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Aliases for USP51 Gene

Aliases for USP51 Gene

  • Ubiquitin Specific Peptidase 51 2 3 5
  • Ubiquitin-Specific-Processing Protease 51 4
  • Ubiquitin Specific Protease 51 2
  • Deubiquitinating Enzyme 51 4
  • Ubiquitin Thioesterase 51 4
  • EC 4
  • EC 63

External Ids for USP51 Gene

Previous GeneCards Identifiers for USP51 Gene

  • GC0XU900509
  • GC0XM054480
  • GC0XM055396
  • GC0XM055529
  • GC0XM052562

Summaries for USP51 Gene

GeneCards Summary for USP51 Gene

USP51 (Ubiquitin Specific Peptidase 51) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP49.

Gene Wiki entry for USP51 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP51 Gene

Genomics for USP51 Gene

Regulatory Elements for USP51 Gene

Enhancers for USP51 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around USP51 on UCSC Golden Path with GeneCards custom track

Promoters for USP51 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around USP51 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP51 Gene

55,484,616 bp from pter
55,489,868 bp from pter
5,253 bases
Minus strand

Genomic View for USP51 Gene

Genes around USP51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP51 Gene

Proteins for USP51 Gene

  • Protein details for USP51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 51
    Protein Accession:
    Secondary Accessions:
    • Q8IWJ8

    Protein attributes for USP51 Gene

    711 amino acids
    Molecular mass:
    79756 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH35907.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for USP51 Gene

Proteomics data for USP51 Gene at MOPED

Post-translational modifications for USP51 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP51 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for USP51 Gene

Gene Families for USP51 Gene

Suggested Antigen Peptide Sequences for USP51 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 UBP-type zinc finger.
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 UBP-type zinc finger.
genes like me logo Genes that share domains with USP51: view

Function for USP51 Gene

Molecular function for USP51 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme Numbers (IUBMB) for USP51 Gene

genes like me logo Genes that share phenotypes with USP51: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP51 Gene

Localization for USP51 Gene

Subcellular locations from

Jensen Localization Image for USP51 Gene COMPARTMENTS Subcellular localization image for USP51 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for USP51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IBA --
genes like me logo Genes that share ontologies with USP51: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for USP51 Gene

Pathways & Interactions for USP51 Gene

genes like me logo Genes that share pathways with USP51: view

Pathways by source for USP51 Gene

1 Qiagen pathway for USP51 Gene

Gene Ontology (GO) - Biological Process for USP51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016578 histone deubiquitination IBA --
genes like me logo Genes that share ontologies with USP51: view

No data available for SIGNOR curated interactions for USP51 Gene

Drugs & Compounds for USP51 Gene

(1) Additional Compounds for USP51 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with USP51: view

Transcripts for USP51 Gene

mRNA/cDNA for USP51 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for USP51 Gene

Ubiquitin specific peptidase 51:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP51 Gene

No ASD Table

Relevant External Links for USP51 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP51 Gene

mRNA expression in normal human tissues for USP51 Gene

SOURCE GeneReport for Unigene cluster for USP51 Gene Hs.40061

mRNA Expression by UniProt/SwissProt for USP51 Gene

Tissue specificity: Expressed in prostate, brain, lung, aorta and kidney.
genes like me logo Genes that share expression patterns with USP51: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for USP51 Gene

Orthologs for USP51 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP51 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Usp51 35
  • 81.85 (n)
  • 78.77 (a)
Usp51 16
Usp51 36
  • 77 (a)
(Pan troglodytes)
Mammalia USP51 35
  • 99.77 (n)
  • 99.58 (a)
USP51 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Usp51 35
  • 82.18 (n)
  • 78.76 (a)
(Monodelphis domestica)
Mammalia USP51 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
(Gallus gallus)
Aves -- 36
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
(Danio rerio)
Actinopterygii usp22 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta not 36
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1941 36
  • 50 (a)
Species with no ortholog for USP51:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP51 Gene

Gene Tree for USP51 (if available)
Gene Tree for USP51 (if available)

Paralogs for USP51 Gene

Paralogs for USP51 Gene

(4) SIMAP similar genes for USP51 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with USP51: view

Variants for USP51 Gene

Sequence variations from dbSNP and Humsavar for USP51 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747753307 -- 55,486,774(+) ATTTA(-/C)CTTTT utr-variant-3-prime
rs748146495 -- 55,485,860(+) CTTTT(G/T)GTCTT downstream-variant-500B, utr-variant-3-prime
rs748282304 -- 55,484,745(+) ATCAC(C/T)GAGGT utr-variant-3-prime
rs749908497 -- 55,486,682(+) TCTTT(A/G)TATCA utr-variant-3-prime
rs2499862 -- 55,484,485(+) TCATA(C/T)CCTGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for USP51 Gene

Variant ID Type Subtype PubMed ID
nsv435891 CNV Deletion 17901297
esv2740175 CNV Deletion 23290073
nsv469510 CNV Complex 16826518
nsv7448 OTHER Inversion 18451855
nsv499493 OTHER Inversion 21111241
nsv524155 CNV Gain 19592680

Variation tolerance for USP51 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for USP51 Gene

Disorders for USP51 Gene

Relevant External Links for USP51

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for USP51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP51 Gene

Publications for USP51 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  3. Genome-wide association study of smoking behaviours among Bangladeshi adults. (PMID: 24665060) Argos M. … Ahsan H. (J. Med. Genet. 2014) 3
  4. A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate. (PMID: 22626734) Loch C.M. … Strickler J.E. (Biochim. Biophys. Acta 2012) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for USP51 Gene

Sources for USP51 Gene