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Aliases for USP50 Gene

Aliases for USP50 Gene

  • Ubiquitin Specific Peptidase 50 2 3 5
  • Inactive Ubiquitin-Specific Peptidase 50 4
  • Ubiquitin Specific Protease 50 2

External Ids for USP50 Gene

Previous GeneCards Identifiers for USP50 Gene

  • GC15U900216
  • GC15M048580
  • GC15M050792
  • GC15M027623
  • GC15M050500

Summaries for USP50 Gene

GeneCards Summary for USP50 Gene

USP50 (Ubiquitin Specific Peptidase 50) is a Protein Coding gene. GO annotations related to this gene include thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP8.

UniProtKB/Swiss-Prot for USP50 Gene

  • Has no peptidase activity.

Additional gene information for USP50 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP50 Gene

Genomics for USP50 Gene

Regulatory Elements for USP50 Gene

Enhancers for USP50 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H050349 1.4 ENCODE dbSUPER 9.9 +194.2 194171 8 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 GABPB1-AS1 ENSG00000259715 USP8 GABPB1-IT1 AHCYP7 ENSG00000259701 ENSG00000259298 AP4E1 ENSG00000259618 HDC
GH15H050358 0.7 ENCODE 9.9 +188.3 188345 0 GTF2F1 CTCF PKNOX1 SIN3A BATF RAD21 GATA3 POLR2A SMC3 FOSL2 USP8 USP50 GABPB1 GABPB1-IT1 ENSG00000259715
GH15H050873 0.7 Ensembl 9.7 -326.7 -326662 1 CTCF PKNOX1 TRIM22 ZNF384 RAD21 JUND ZNF512 CEBPA SMC3 CUX1 AP4E1 TRPM7 RN7SL354P USP50 SPPL2A ENSG00000259306 GC15P050883 PIR42507
GH15H050523 0.2 ENCODE 21.7 +23.5 23497 0 USP50 GC15P050544 ENSG00000259298
GH15H050466 0.4 ENCODE 10.7 +80.6 80611 1 YBX1 USP8 USP50 SPPL2A GC15P050467 GC15P050469
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around USP50 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP50 Gene

Chromosome:
15
Start:
50,493,681 bp from pter
End:
50,547,439 bp from pter
Size:
53,759 bases
Orientation:
Minus strand

Genomic View for USP50 Gene

Genes around USP50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP50 Gene

Proteins for USP50 Gene

  • Protein details for USP50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70EL3-UBP50_HUMAN
    Recommended name:
    Inactive ubiquitin carboxyl-terminal hydrolase 50
    Protein Accession:
    Q70EL3
    Secondary Accessions:
    • E9PP86

    Protein attributes for USP50 Gene

    Size:
    339 amino acids
    Molecular mass:
    38955 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for USP50 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP50 Gene

Post-translational modifications for USP50 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP50 Gene

No data available for DME Specific Peptides for USP50 Gene

Domains & Families for USP50 Gene

Gene Families for USP50 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for USP50 Gene

Suggested Antigen Peptide Sequences for USP50 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q70EL3

UniProtKB/Swiss-Prot:

UBP50_HUMAN :
  • Belongs to the peptidase C19 family.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP50: view

Function for USP50 Gene

Molecular function for USP50 Gene

UniProtKB/Swiss-Prot Function:
Has no peptidase activity.

Phenotypes From GWAS Catalog for USP50 Gene

Gene Ontology (GO) - Molecular Function for USP50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP50: view

Phenotypes for USP50 Gene

genes like me logo Genes that share phenotypes with USP50: view

Animal Models for USP50 Gene

MGI Knock Outs for USP50:

Animal Model Products

  • Taconic Biosciences Mouse Models for USP50

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for USP50
  • Applied Biological Materials Clones for USP50
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for USP50 Gene

Localization for USP50 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP50 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for USP50 Gene

Pathways & Interactions for USP50 Gene

SuperPathways for USP50 Gene

No Data Available

Gene Ontology (GO) - Biological Process for USP50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IEA --
genes like me logo Genes that share ontologies with USP50: view

No data available for Pathways by source and SIGNOR curated interactions for USP50 Gene

Drugs & Compounds for USP50 Gene

No Compound Related Data Available

Transcripts for USP50 Gene

mRNA/cDNA for USP50 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for USP50 Gene

Ubiquitin specific peptidase 50:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for USP50
  • Applied Biological Materials Clones for USP50
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for USP50 Gene

No ASD Table

Relevant External Links for USP50 Gene

GeneLoc Exon Structure for
USP50
ECgene alternative splicing isoforms for
USP50

Expression for USP50 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP50 Gene

mRNA differential expression in normal tissues according to GTEx for USP50 Gene

This gene is overexpressed in Testis (x29.6).

Protein differential expression in normal tissues from HIPED for USP50 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for USP50 Gene



Protein tissue co-expression partners for USP50 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of USP50 Gene:

USP50

SOURCE GeneReport for Unigene cluster for USP50 Gene:

Hs.677758

mRNA Expression by UniProt/SwissProt for USP50 Gene:

Q70EL3-UBP50_HUMAN
Tissue specificity: Weakly expressed in a few tissues.
genes like me logo Genes that share expression patterns with USP50: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP50 Gene

Orthologs for USP50 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP50 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP50 33 34
  • 98.39 (n)
cow
(Bos Taurus)
Mammalia USP50 33 34
  • 87.25 (n)
dog
(Canis familiaris)
Mammalia LOC608487 33
  • 84.64 (n)
USP50 34
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp50 33
  • 81.2 (n)
mouse
(Mus musculus)
Mammalia Usp50 33 16 34
  • 79.27 (n)
oppossum
(Monodelphis domestica)
Mammalia USP50 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP50 34
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP50 34
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea E01B7.1 34
  • 11 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP5 34
  • 12 (a)
ManyToMany
DOA4 34
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.895 34
  • 24 (a)
ManyToMany
Species where no ortholog for USP50 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for USP50 Gene

ENSEMBL:
Gene Tree for USP50 (if available)
TreeFam:
Gene Tree for USP50 (if available)

Paralogs for USP50 Gene

Paralogs for USP50 Gene

(3) SIMAP similar genes for USP50 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with USP50: view

Variants for USP50 Gene

Sequence variations from dbSNP and Humsavar for USP50 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000087900 -- 50,544,964(+) AGAGC(A/G)TAGTG intron-variant, nc-transcript-variant
rs1000226482 -- 50,533,282(+) AAAGA(A/G)CAGAA intron-variant
rs1000436438 -- 50,527,562(+) GACCA(C/T)ACCTT intron-variant
rs1000484662 -- 50,547,195(+) TCTGA(A/T)TTTGA upstream-variant-2KB
rs1000552933 -- 50,539,099(+) ATCAG(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP50 Gene

Variant ID Type Subtype PubMed ID
dgv2594n100 CNV gain 25217958
dgv317n27 CNV gain 19166990
dgv4525n54 CNV gain 21841781
esv3552434 CNV deletion 23714750
esv3636443 CNV loss 21293372
esv3636444 CNV loss 21293372
nsv1047443 CNV gain 25217958
nsv1049576 CNV gain 25217958
nsv1116072 CNV deletion 24896259
nsv1131185 CNV deletion 24896259
nsv471242 CNV gain 18288195
nsv524613 CNV loss 19592680
nsv569398 CNV loss 21841781

Variation tolerance for USP50 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP50 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP50

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP50 Gene

Disorders for USP50 Gene

Relevant External Links for USP50

Genetic Association Database (GAD)
USP50
Human Genome Epidemiology (HuGE) Navigator
USP50
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP50

No disorders were found for USP50 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP50 Gene

Publications for USP50 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V … López-Otín C (Biochemical and biophysical research communications 2004) 3 4 60
  3. A genomic analysis of rat proteases and protease inhibitors. (PMID: 15060002) Puente XS … López-Otín C (Genome research 2004) 3 4 60
  4. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3 60
  5. The deubiquitinating enzyme USP50 regulates inflammasome activation through targeting the ASC adaptor protein. (PMID: 28094437) Lee JY … Park SH (FEBS letters 2017) 3 60

Products for USP50 Gene

  • Addgene plasmids for USP50

Sources for USP50 Gene

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