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Aliases for USP50 Gene

Aliases for USP50 Gene

  • Ubiquitin Specific Peptidase 50 2 3
  • Inactive Ubiquitin-Specific Peptidase 50 4
  • Ubiquitin Specific Protease 50 2

External Ids for USP50 Gene

Previous GeneCards Identifiers for USP50 Gene

  • GC15U900216
  • GC15M048580
  • GC15M050792
  • GC15M027623

Summaries for USP50 Gene

GeneCards Summary for USP50 Gene

USP50 (Ubiquitin Specific Peptidase 50) is a Protein Coding gene. GO annotations related to this gene include ubiquitin thiolesterase activity. An important paralog of this gene is USP49.

UniProtKB/Swiss-Prot for USP50 Gene

  • Has no peptidase activity

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP50 Gene

Genomics for USP50 Gene

Regulatory Elements for USP50 Gene

Genomic Location for USP50 Gene

Start:
50,500,562 bp from pter
End:
50,546,708 bp from pter
Size:
46,147 bases
Orientation:
Minus strand

Genomic View for USP50 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP50 Gene

Proteins for USP50 Gene

  • Protein details for USP50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70EL3-UBP50_HUMAN
    Recommended name:
    Inactive ubiquitin carboxyl-terminal hydrolase 50
    Protein Accession:
    Q70EL3
    Secondary Accessions:
    • E9PP86

    Protein attributes for USP50 Gene

    Size:
    339 amino acids
    Molecular mass:
    38955 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for USP50 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP50 Gene

Proteomics data for USP50 Gene at MOPED

Post-translational modifications for USP50 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP50 Gene

No data available for DME Specific Peptides for USP50 Gene

Domains for USP50 Gene

Gene Families for USP50 Gene

HGNC:
  • USP :Ubiquitin-specific peptidases

Protein Domains for USP50 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for USP50 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q70EL3

UniProtKB/Swiss-Prot:

UBP50_HUMAN :
  • Q70EL3
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP50: view

Function for USP50 Gene

Molecular function for USP50 Gene

UniProtKB/Swiss-Prot Function: Has no peptidase activity

Gene Ontology (GO) - Molecular Function for USP50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036459 ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP50: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP50

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for USP50 Gene

Localization for USP50 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP50 Gene COMPARTMENTS Subcellular localization image for USP50 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP50 Gene

Pathways for USP50 Gene

SuperPathways for USP50 Gene

No Data Available

Gene Ontology (GO) - Biological Process for USP50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with USP50: view

No data available for Pathways by source for USP50 Gene

Transcripts for USP50 Gene

mRNA/cDNA for USP50 Gene

(7) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(5) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for USP50 Gene

Ubiquitin specific peptidase 50:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP50

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for USP50
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP50 Gene

No ASD Table

Relevant External Links for USP50 Gene

GeneLoc Exon Structure for
USP50
ECgene alternative splicing isoforms for
USP50

Expression for USP50 Gene

mRNA expression in normal human tissues for USP50 Gene

mRNA differential expression in normal tissues according to GTEx for USP50 Gene

This gene is overexpressed in Testis (29.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for USP50 Gene

SOURCE GeneReport for Unigene cluster for USP50 Gene Hs.677758

mRNA Expression by UniProt/SwissProt for USP50 Gene

Q70EL3-UBP50_HUMAN
Tissue specificity: Weakly expressed in a few tissues.
genes like me logo Genes that share expressions with USP50: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for USP50 Gene

Orthologs for USP50 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP50 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP50 35
  • 98.39 (n)
  • 97.89 (a)
USP50 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia USP50 35
  • 87.25 (n)
  • 82.53 (a)
USP50 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC608487 35
  • 84.64 (n)
  • 82.83 (a)
USP50 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp50 35
  • 79.27 (n)
  • 78.96 (a)
Usp50 16
Usp50 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia USP50 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP50 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp50 35
  • 81.2 (n)
  • 80.49 (a)
lizard
(Anolis carolinensis)
Reptilia USP50 36
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea E01B7.1 36
  • 11 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DOA4 36
  • 11 (a)
ManyToMany
UBP5 36
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.895 36
  • 24 (a)
ManyToMany
Species with no ortholog for USP50:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for USP50 Gene

ENSEMBL:
Gene Tree for USP50 (if available)
TreeFam:
Gene Tree for USP50 (if available)

Paralogs for USP50 Gene

Paralogs for USP50 Gene

Selected SIMAP similar genes for USP50 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with USP50: view

Variants for USP50 Gene

Sequence variations from dbSNP and Humsavar for USP50 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs484387 -- 50,544,277(+) GGGTC(A/G)CTTGA intron-variant
rs536037 -- 50,542,431(+) CTTTT(C/T)TTAAA intron-variant
rs591829 -- 50,545,472(-) TATGT(G/T)GGGAG intron-variant
rs647375 -- 50,539,257(+) gtgcg(C/T)accac intron-variant
rs679774 -- 50,539,979(+) GTGTC(A/G)GGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP50 Gene

Variant ID Type Subtype PubMed ID
nsv524613 CNV Loss 19592680
nsv471242 CNV Gain 18288195
dgv317n27 CNV Gain 19166990

Relevant External Links for USP50 Gene

HapMap Linkage Disequilibrium report
USP50

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP50 Gene

Disorders for USP50 Gene

Relevant External Links for USP50

Genetic Association Database (GAD)
USP50
Human Genome Epidemiology (HuGE) Navigator
USP50
genes like me logo Genes that share disorders with USP50: view

No data available for UniProtKB/Swiss-Prot for USP50 Gene

Publications for USP50 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 3 4
  3. A genomic analysis of rat proteases and protease inhibitors. (PMID: 15060002) Puente X.S. … Lopez-Otin C. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. A screen for deubiquitinating enzymes involved in the Ga88/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability. (PMID: 20930503) Aressy B. … Ducommun B. (Cell Cycle 2010) 3

Products for USP50 Gene

Sources for USP50 Gene

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