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Aliases for USP50 Gene

Aliases for USP50 Gene

  • Ubiquitin Specific Peptidase 50 2 3 5
  • Inactive Ubiquitin-Specific Peptidase 50 4
  • Ubiquitin Specific Protease 50 2

External Ids for USP50 Gene

Previous GeneCards Identifiers for USP50 Gene

  • GC15U900216
  • GC15M048580
  • GC15M050792
  • GC15M027623
  • GC15M050500

Summaries for USP50 Gene

GeneCards Summary for USP50 Gene

USP50 (Ubiquitin Specific Peptidase 50) is a Protein Coding gene. GO annotations related to this gene include thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP8.

UniProtKB/Swiss-Prot for USP50 Gene

  • Has no peptidase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP50 Gene

Genomics for USP50 Gene

Regulatory Elements for USP50 Gene

Enhancers for USP50 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F050523 0.4 ENCODE 21.7 +23.5 23497 0.4 SIX4 FEZF1 ZNF2 ZNF121 CTBP1 GATA3 ZFHX2 ZNF366 PATZ1 ZNF207 USP50 GC15P050544 ENSG00000259298
GH15F050598 0.6 FANTOM5 11.2 -50.8 -50793 0.0 PKNOX1 AP4E1 USP50 SPPL2A USP8 TRPM7 GC15P050592 GC15P050610
GH15F050501 0.3 FANTOM5 10.9 +46.0 46002 0.2 USP50 USP8 TRPM7 ENSG00000259298 GC15P050544
GH15F050466 1.1 ENCODE 10.7 +80.6 80611 1.4 CTBP1 GATA3 RFX1 MTA1 YBX1 FOS CUX1 ZBTB40 USP8 USP50 SPPL2A GC15P050467 GC15P050469
GH15F050378 0.2 Ensembl 10.4 +168.9 168939 0.2 RFX1 HLF IKZF1 TBX21 USP8 GABPB1-AS1 MIR4712 USP50 TRPM7 RN7SL354P GC15P050373 GC15P050389
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around USP50 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP50 Gene

Chromosome:
15
Start:
50,493,681 bp from pter
End:
50,547,439 bp from pter
Size:
53,759 bases
Orientation:
Minus strand

Genomic View for USP50 Gene

Genes around USP50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP50 Gene

Proteins for USP50 Gene

  • Protein details for USP50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70EL3-UBP50_HUMAN
    Recommended name:
    Inactive ubiquitin carboxyl-terminal hydrolase 50
    Protein Accession:
    Q70EL3
    Secondary Accessions:
    • E9PP86

    Protein attributes for USP50 Gene

    Size:
    339 amino acids
    Molecular mass:
    38955 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for USP50 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP50 Gene

Post-translational modifications for USP50 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP50 Gene

No data available for DME Specific Peptides for USP50 Gene

Domains & Families for USP50 Gene

Gene Families for USP50 Gene

Protein Domains for USP50 Gene

Suggested Antigen Peptide Sequences for USP50 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q70EL3

UniProtKB/Swiss-Prot:

UBP50_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP50: view

Function for USP50 Gene

Molecular function for USP50 Gene

UniProtKB/Swiss-Prot Function:
Has no peptidase activity.

Gene Ontology (GO) - Molecular Function for USP50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP50: view

Phenotypes for USP50 Gene

genes like me logo Genes that share phenotypes with USP50: view

Animal Models for USP50 Gene

MGI Knock Outs for USP50:

Animal Model Products

  • Taconic Biosciences Mouse Models for USP50

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for USP50

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for USP50 Gene

Localization for USP50 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP50 Gene COMPARTMENTS Subcellular localization image for USP50 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP50 Gene

Pathways & Interactions for USP50 Gene

SuperPathways for USP50 Gene

No Data Available

Gene Ontology (GO) - Biological Process for USP50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IEA --
genes like me logo Genes that share ontologies with USP50: view

No data available for Pathways by source and SIGNOR curated interactions for USP50 Gene

Transcripts for USP50 Gene

mRNA/cDNA for USP50 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for USP50 Gene

Ubiquitin specific peptidase 50:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for USP50

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP50 Gene

No ASD Table

Relevant External Links for USP50 Gene

GeneLoc Exon Structure for
USP50
ECgene alternative splicing isoforms for
USP50

Expression for USP50 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USP50 Gene

mRNA differential expression in normal tissues according to GTEx for USP50 Gene

This gene is overexpressed in Testis (x29.6).

Protein differential expression in normal tissues from HIPED for USP50 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for USP50 Gene



Protein tissue co-expression partners for USP50 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of USP50 Gene:

USP50

SOURCE GeneReport for Unigene cluster for USP50 Gene:

Hs.677758

mRNA Expression by UniProt/SwissProt for USP50 Gene:

Q70EL3-UBP50_HUMAN
Tissue specificity: Weakly expressed in a few tissues.
genes like me logo Genes that share expression patterns with USP50: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for USP50 Gene

Orthologs for USP50 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP50 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP50 34 35
  • 98.39 (n)
cow
(Bos Taurus)
Mammalia USP50 34 35
  • 87.25 (n)
dog
(Canis familiaris)
Mammalia LOC608487 34
  • 84.64 (n)
USP50 35
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp50 34
  • 81.2 (n)
mouse
(Mus musculus)
Mammalia Usp50 34 16 35
  • 79.27 (n)
oppossum
(Monodelphis domestica)
Mammalia USP50 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP50 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP50 35
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea E01B7.1 35
  • 11 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP5 35
  • 12 (a)
ManyToMany
DOA4 35
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.895 35
  • 24 (a)
ManyToMany
Species where no ortholog for USP50 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for USP50 Gene

ENSEMBL:
Gene Tree for USP50 (if available)
TreeFam:
Gene Tree for USP50 (if available)

Paralogs for USP50 Gene

Paralogs for USP50 Gene

(3) SIMAP similar genes for USP50 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with USP50: view

Variants for USP50 Gene

Sequence variations from dbSNP and Humsavar for USP50 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10152881 -- 50,518,463(+) acctc(A/G)gcctc intron-variant
rs10431778 -- 50,504,825(+) aaaac(A/C)aaaaa intron-variant
rs10519279 -- 50,539,935(+) GCGCA(C/G)ATTTT intron-variant
rs11070790 -- 50,546,821(+) AACTA(A/C)ACATA upstream-variant-2KB
rs111228209 -- 50,501,393(+) CTCTC(A/G)AGCCT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for USP50 Gene

Variant ID Type Subtype PubMed ID
dgv2594n100 CNV gain 25217958
dgv317n27 CNV gain 19166990
dgv4525n54 CNV gain 21841781
esv3552434 CNV deletion 23714750
esv3636443 CNV loss 21293372
esv3636444 CNV loss 21293372
nsv1047443 CNV gain 25217958
nsv1049576 CNV gain 25217958
nsv1116072 CNV deletion 24896259
nsv1131185 CNV deletion 24896259
nsv471242 CNV gain 18288195
nsv524613 CNV loss 19592680
nsv569398 CNV loss 21841781

Variation tolerance for USP50 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP50 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP50

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP50 Gene

Disorders for USP50 Gene

Relevant External Links for USP50

Genetic Association Database (GAD)
USP50
Human Genome Epidemiology (HuGE) Navigator
USP50
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP50

No disorders were found for USP50 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP50 Gene

Publications for USP50 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 3 4 64
  3. A genomic analysis of rat proteases and protease inhibitors. (PMID: 15060002) Puente X.S. … Lopez-Otin C. (Genome Res. 2004) 3 4 64
  4. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 64
  5. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. (PMID: 24952745) Arking D.E. … Newton-Cheh C. (Nat. Genet. 2014) 3 64

Products for USP50 Gene

Sources for USP50 Gene

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