USP50 Gene
protein-coding GIFtS: 39
GCID: GC15M050792
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ubiquitin specific peptidase 50(Previous name: ubiquitin specific protease 50 )
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Aliases
for USP50 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 501 2 | | Ubiquitin Specific Protease 501 2 | | Inactive Ubiquitin-Specific Peptidase 502 3 | | Inactive Ubiquitin Carboxyl-Terminal Hydrolase 502 |
Export aliases for USP50 gene to outside databasesPrevious GC identifers: GC15U900216 GC15M048580 GC15M027623 |
Summaries
for USP50 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UBP50_HUMAN, Q70EL3Function: Has no peptidase activity
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Genomic Views
for USP50 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP50 gene promoter:
Nkx3-1 v4 RFX1 AML1a Cdc5 HNF-1A Nkx3-1 v2 HEN1 HNF-1 Nkx3-1 v3 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP50
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP50 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q21.1 Ensembl cytogenetic band: 15q21.2 HGNC cytogenetic band: 15q21.1USP50 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M050792: view genomic region
(about GC identifiers)
Start:
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50,792,759 bp from pter |
End:
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50,838,905 bp from pter |
Size:
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46,147 bases |
Orientation:
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minus strand |
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Proteins
for USP50 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP50_HUMAN, Q70EL3 (See
protein sequence)Recommended Name: Inactive ubiquitin carboxyl-terminal hydrolase 50 Size: 339 amino acids; 38955 Da
Caution: Although the active site residues are conserved, lacks the conserved Asp/Asn residue which is normally found7-9 residues after the catalytic HisExplore the universe of human proteins at neXtProt for USP50: NX_Q70EL3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q70EL3
USP50 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_987090.2
ENSEMBL proteins: ENSP00000434676 ENSP00000453946 ENSP00000434014
Human Recombinant Protein Products:
USP50 Antibody Products:
Assay Products for USP50: |
Protein
Domains /
Families
for USP50 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP50 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q70EL3ProtoNet protein and cluster: Q70EL3 UniProtKB/Swiss-Prot: UBP50_HUMAN, Q70EL3Similarity: Belongs to the peptidase C19 family |
Function
for USP50 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBP50_HUMAN, Q70EL3Function: Has no peptidase activity
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP50 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP50
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: USP50 (NM_203494) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP50 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP50 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP50 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004221 | ubiquitin thiolesterase activity |
IEA | -- |
USP50 for ontologies About GeneDecksing
Animal Models:
1 MGI phenotypic allele  for Usp50 (no phenotypes)
USP50 for phenotypes About GeneDecksing
|
Pathways & Interactions
for USP50 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP50
5/23 Interacting proteins for USP50 (Q70EL33) via UniProtKB, MINT, STRING, and/or I2D (see all 23)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- |
USP50 for ontologies About GeneDecksing
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Drugs & Compounds
for USP50 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USP50
Search CenterWatch for drugs/clinical trials and news about USP50 / UBP50
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Transcripts
for USP50 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP50 gene: NM_203494.4 Unigene Cluster for USP50: Ubiquitin specific peptidase 50 Hs.677758 [show with all ESTs]Unigene Representative Sequence: NM_2034944 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000532404(uc021skx.1 uc021sky.1) ENST00000559105 ENST00000530218
ENST00000529349
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP50 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP50
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: USP50 (NM_203494) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP50 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP50 |
Additional cDNA sequence: AJ583818.2 2 DOTS entries: DT.102841822 DT.121045188 7 AceView cDNA sequences: BN000339 BE832280 AJ583818 NM_203494 AI990110 AI990671 BE832251
GeneLoc Exon Structure
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Expression
for USP50 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP50 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
SOURCE GeneReport for Unigene cluster: Hs.677758
UniProtKB/Swiss-Prot: UBP50_HUMAN, Q70EL3Tissue specificity: Weakly expressed in a few tissues
SABiosciences Custom PCR Arrays for USP50
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP50
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP50 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP50 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP50 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP50 |
Orthologs
for USP50 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for USP50 gene from 3/15 species (see all 15) About this table
ENSEMBL Gene Tree for USP50 (if available)
TreeFam Gene Tree for USP50 (if available) |
Paralogs
for USP50 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP50 gene
- USP17L132 USP17L282 USP17L242 USP17L302 USP17L122 USP17L172 USP17L262 USP17L232
- USP17L182 USP422 USP17L252 USP82 USP17L152 USP17L212 USP17L202 USP17L192
- USP17L102 USP22 USP362 USP17L272 USP212 USP17L222 USP17L52 USP17L22
- USP17L292 USP17L112
3 SIMAP similar genes for USP50 using alignment to 5 protein entries: UBP50_HUMAN (see all proteins):USP15 USP8 USP11
USP50 for paralogs About GeneDecksing
|
Genomic Variants
for USP50 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP50 (50792759 - 50838905 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for USP50
2 CNVs: 53349 29644 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP50 |
|
Disorders
/ Diseases
for USP50 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP50 for disorders About GeneDecksing
1  disease for USP50: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: USP50 (1 document)
Export disorders for USP50 gene to outside databases
|
Publications
for USP50 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USP50 gene integrated from 9 sources:
(articles sorted by number of sources associating them with USP50) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A genomic analysis of rat proteases and protease inhibitors. (PubMed id 15060002)1, 2 Puente X.S. and Lopez-Otin C. (2004)
- Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (2004)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- A screen for deubiquitinating enzymes involved in the Ga88/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stabil ity. (PubMed id 20930503)1 Aressy B....Ducommun B. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
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External Searches for USP50 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing USP50 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USP50 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing USP50 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for USP50 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for USP50 gene:
Search GeneIP for patents involving USP50
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for USP50 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for USP50 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP50 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP50 | | | OriGene Protein Over-expression Lysate for USP50 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for USP50 | | OriGene 3'-UTR Clone for USP50 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP50 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP50 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP50 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP50 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP50 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP50 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP50 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP50 |
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 |  |  |  | |
| | | | Search Tocris compounds for USP50 |
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 | | | USP50 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP50 |
|  |  |  | | | | Search ThermoFisher Antibodies for USP50 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP50 |
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