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USP5 Gene

protein-coding   GIFtS: 64
GCID: GC12P007137

Ubiquitin Specific Peptidase 5 (Isopeptidase T)

(Previous name: ubiquitin specific protease 5 (isopeptidase T))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 5 (Isopeptidase T)1 2     Ubiquitin Carboxyl-Terminal Hydrolase 52
ISOT2 3 5     Ubiquitin Isopeptidase T2
Ubiquitin Specific Protease 5 (Isopeptidase T)1 2     Ubiquitin Thiolesterase 52
Deubiquitinating Enzyme 52 3     Ubiquitin-Specific Protease-5 (Ubiquitin Isopeptidase T)2
Isopeptidase T2 3     EC 3.4.19.123
Ubiquitin Thioesterase 52 3     EC 3.1.2.158
Ubiquitin-Specific-Processing Protease 52 3     

External Ids:    HGNC: 126281   Entrez Gene: 80782   Ensembl: ENSG000001116677   OMIM: 6014475   UniProtKB: P459743   

Export aliases for USP5 gene to outside databases

Previous GC identifers: GC12M006999 GC12M007084 GC12P006840 GC12P006831 GC12P006815 GC12P006978 GC12P006985 GC12P006991 GC12P006998 GC12P007006 GC12P007024 GC12P007047 GC12P007111


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USP5 Gene:
Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such
diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal
proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into
ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at
the proximal end of the chain (Wilkinson et al., 1995 (PubMed 7578059)).(supplied by OMIM, Mar 2010)

GeneCards Summary for USP5 Gene:
USP5 (ubiquitin specific peptidase 5 (isopeptidase T)) is a protein-coding gene. GO annotations related to this gene include omega peptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP13.

UniProtKB/Swiss-Prot: UBP5_HUMAN, P45974
Function: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers.
Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin
with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53
transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with
ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition

Gene Wiki entry for USP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009759.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP5 gene promoter:
         c-Fos   PPAR-gamma1   AP-1   ATF-2   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP5 promoter sequence
   Search Chromatin IP Primers for USP5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

USP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P007137:  view genomic region     (about GC identifiers)

Start:
6,961,285 bp from pter      End:
6,975,796 bp from pter
Size:
14,512 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBP5_HUMAN, P45974 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 5  
Size: 858 amino acids; 95786 Da
Cofactor: Binds 1 zinc ion
Subunit: Interacts with TRIML1 (By similarity)
Miscellaneous: The UBP-type zinc finger domain crystallizes as a dimer linked by a disulfide bond between the
Cys-195 residues of both molecules, but there is no evidence that the full-length USP5 exists as a dimer
5 PDB 3D structures from and Proteopedia for USP5:
2DAG (3D)        2DAK (3D)        2G43 (3D)        2G45 (3D)        3IHP (3D)    
Secondary accessions: D3DUS7 D3DUS8 Q96J22
Alternative splicing: 2 isoforms:  P45974-1   P45974-2   

Explore the universe of human proteins at neXtProt for USP5: NX_P45974

Explore proteomics data for USP5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys20, Lys163, Lys184, Lys318, Lys353, Lys357, Lys360, Lys391, Lys423, Lys553,
                                 Lys575, Lys586, Lys743, Lys793, Lys836
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for USP5 (P45974) (see all 15)
     VKLGTIT  ACRKAVY  ERAVDWI  GSSGPGS 


    See USP5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001092006.1  NP_003472.2  

    ENSEMBL proteins: 
     ENSP00000229268   ENSP00000373883   ENSP00000444668  

    USP5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for USP5
    OriGene Purified Protein for USP5
    OriGene Protein Over-expression Lysate for USP5
    OriGene MassSpec for USP5
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    Novus Biologicals USP5 Proteins
    Novus Biologicals USP5 Lysate
    Sino Biological Recombinant Protein for USP5
    Sino Biological Cell Lysate for USP5
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP5

     
    Search eBioscience for Proteins for USP5 

     
    antibodies-online proteins for USP5 (6 products) 

     
    antibodies-online peptides for USP5

    USP5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for USP5
    antibodies-online antibodies for USP5 (40 products) 

    USP5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for USP5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP5
    Cloud-Clone Corp. CLIAs for USP5
    Search eBioscience for ELISAs for USP5 
    antibodies-online kits for USP5 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    Selected InterPro protein domains (see all 9):
     IPR001394 Peptidase_C19_UCH
     IPR016652 Ubiquitinyl_hydrolase
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR013083 Znf_RING/FYVE/PHD
     IPR028889 UCH/PAN2

    Graphical View of Domain Structure for InterPro Entry P45974

    ProtoNet protein and cluster: P45974

    3 Blocks protein domains:
    IPB000449 Ubiquitin-associated domain
    IPB001394 Ubiquitin thiolesterase
    IPB001607 Zn-finger in ubiquitin thiolesterase


    UniProtKB/Swiss-Prot: UBP5_HUMAN, P45974
    Domain: The UBP-type zinc finger domain interacts selectively with an unmodified C-terminus of the proximal
    ubiquitin. Both UBA domains are involved in polyubiquitin recognition
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 2 UBA domains
    Similarity: Contains 1 UBP-type zinc finger
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP5_HUMAN, P45974
    Function: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers.
    Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin
    with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53
    transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with
    ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP5:
    ubiquitin specific protease 5,100kDa,expressed in brain,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity TAS7578059
    GO:0004221ubiquitin thiolesterase activity TAS7578059
    GO:0005515protein binding IPI16189514
    GO:0008242omega peptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with USP5           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Usp5):
     mortality/aging 

    Find genes that share phenotypes with USP5           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP5

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP5:
    hsa-mir-455-3p (MIRT037909), hsa-mir-124-3p (MIRT022686), hsa-mir-1180-3p (MIRT035949), hsa-mir-1260b (MIRT052708), hsa-mir-484 (MIRT042352), hsa-mir-30a-5p (MIRT028484)

    Block miRNA regulation of human, mouse, rat USP5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP5 (see all 14):
    hsa-miR-130a* hsa-miR-1271 hsa-miR-2278 hsa-miR-23c hsa-miR-520a-5p hsa-miR-182 hsa-miR-370 hsa-miR-23b
    SwitchGear 3'UTR luciferase reporter plasmidUSP5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP5
    Predesigned siRNA for gene silencing in human, mouse, rat USP5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP5

    Clone
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    OriGene clones in human, mouse for USP5 (see all 13)
    OriGene ORF clones in mouse, rat for USP5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP5 (NM_004419)
    Sino Biological Human cDNA Clone for USP5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP5
    Addgene plasmids for USP5 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for USP5
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP5 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome4
    vacuole4
    cytosol2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome TAS9827704

    Find genes that share ontologies with USP5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP5 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP5
        Ubiquitin-Proteasome Dependent Proteolysis



        Pathway & Disease-focused RT2 Profiler PCR Array including USP5: 
              Prostate Cancer in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for USP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP5 (P459741, 2, 3 ENSP000002292684) via UniProtKB, MINT, STRING, and/or I2D (see all 105)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF11Q9Y3C52, 3MINT-60847 I2D: score=2 
    RAD23BP547271, 2, 3, ENSP000003507084EBI-741277,EBI-954531 MINT-2791131 MINT-2791444 I2D: score=1 STRING: ENSP00000350708
    RPL9P329693I2D: score=1 
    RPL9P7P329693I2D: score=1 
    RPL9P8P329693I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP19098288
    GO:0071108protein K48-linked deubiquitination IMP19098288

    Find genes that share ontologies with USP5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for USP5
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP5 (UBP5)

    1 HMDB Compound for USP5    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 Novoseek inferred chemical compound relationships for USP5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 25.4 1 17449248 (1)
    zinc 24.5 8 17512543 (2), 12435595 (2)



    Find genes that share compounds with USP5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP5 gene (2 alternative transcripts): 
    NM_001098536.1  NM_003481.2  

    Unigene Cluster for USP5:

    Ubiquitin specific peptidase 5 (isopeptidase T)
    Hs.631661  [show with all ESTs]
    Unigene Representative Sequence: NM_001098536
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229268(uc001qrh.4 uc001qri.4) ENST00000389231 ENST00000542087
    ENST00000535080 ENST00000537267 ENST00000541969 ENST00000542371
    miRNA
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    Block miRNA regulation of human, mouse, rat USP5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP5 (see all 14):
    hsa-miR-130a* hsa-miR-1271 hsa-miR-2278 hsa-miR-23c hsa-miR-520a-5p hsa-miR-182 hsa-miR-370 hsa-miR-23b
    SwitchGear 3'UTR luciferase reporter plasmidUSP5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat USP5
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    GenScript: all cDNA clones in your preferred vector: USP5 (NM_004419)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP5
    Addgene plasmids for USP5 
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      QuantiTect SYBR Green Assays in human, mouse, rat USP5
      QuantiFast Probe-based Assays in human, mouse, rat USP5

    Additional mRNA sequence: 

    AK308021.1 BC004889.2 BC005139.2 U35116.1 U47927.1 X91349.1 

    17 DOTS entries:

    DT.100822891  DT.97855337  DT.92449342  DT.86855142  DT.100038284  DT.92449347  DT.101986303  DT.97762970 
    DT.100760153  DT.121170406  DT.100658021  DT.100822894  DT.100822898  DT.100822903  DT.102841601  DT.102841609 
    DT.95313280 

    9 AceView cDNA sequences:

    CR620906 BC005139 U47927 CR598459 CR621700 BC004889 U35116 NM_003481 
    X91349 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for USP5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c
    SP1:                                                                                                                                                
    SP2:                                                                                                  -                                             
    SP3:                                                                                                                                                


    ECgene alternative splicing isoforms for USP5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGAGAGGG
    USP5 Expression
    About this image

    USP5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631661
        Pathway & Disease-focused RT2 Profiler PCR Array including USP5: 
              Prostate Cancer in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for USP5
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    QuantiFast Probe-based Assays in human, mouse, rat USP5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USP5 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp51 , 5 ubiquitin specific peptidase 5 (isopeptidase T)1, 5 91.96(n)1
    98.37(a)1
      6 (59.17 cM)5
    222251  NM_013700.11  NP_038728.11 
     1248150195 
    chicken
    (Gallus gallus)
    Aves USP51 ubiquitin specific peptidase 5 (isopeptidase T) 81.33(n)
    91.35(a)
      418290  XM_003640442.2  XP_003640490.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP56
    ubiquitin specific peptidase 5 (isopeptidase T)
    89(a)
    1 ↔ 1
    GL343453.1(422726-451118)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC056002.12   -- 78.34(n)    BC056002.1 
    zebrafish
    (Danio rerio)
    Actinopterygii usp51 ubiquitin specific protease 5 66.87(n)
    70.22(a)
      406618  NM_214755.2  NP_999920.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120821 , 3 protein deubiquitination ubiquitin
    isopeptidase more3
    CG120821
    50(a)3
    58.62(n)1
    53.61(a)1
      63B63
    383751  NM_139516.11  NP_647773.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T27A3.23 ubiquitin carboxyl-terminal hydrolase 35(a)   I(6118275-6122458)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP14(YBR058C)4 Ubiquitin-specific protease that specifically disassembles more   --   2(356017-353672) 852349  NP_009614.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBP141 UBP14 55.85(n)
    52.04(a)
      821610  NM_112954.3  NP_566666.2 
    rice
    (Oryza sativa)
    Liliopsida Os.71732 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 76.59(n)    AK103230.1 


    ENSEMBL Gene Tree for USP5 (if available)
    TreeFam Gene Tree for USP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP5 gene
    USP132  
    1 SIMAP similar gene for USP5 using alignment to 2 protein entries:     UBP5_HUMAN (see all proteins):
    USP13

    Find genes that share paralogs with USP5           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for USP5
    PGOHUM00000248261


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP5 (see all 335)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30327901,2
    C--6959326(+) TGTGT-/GT/TG 
            
    TATGT
    2 -- us2k11NA 2
    rs1441551371,2
    --6962524(+) GATTTG/TTGGTT 2 -- int10--------
    rs1854875431,2
    --6962596(+) CTTTGG/TCAGAG 2 -- int10--------
    rs1892191411,2
    --6962721(+) GGAGGA/GAAAGG 2 -- int10--------
    rs1911551991,2
    --6962810(+) AGTAAA/CTGCTT 2 -- int10--------
    rs1148403681,2
    C,F--6962920(+) TTCCAG/ACATAT 2 -- int11Minor allele frequency- A:0.05WA 118
    rs1840760651,2
    --6962975(+) ACCTCC/GCCGGT 2 -- int10--------
    rs10768651,2
    C,F,H--6962978(-) CTCACC/TGGGGA 2 -- int128Minor allele frequency- T:0.20NA NS EA WA 4374
    rs1444482401,2
    --6963055(+) TGGGAC/TCAAGA 2 -- int10--------
    rs46081811,2
    F,H--6963071(-) CACTGT/GCTAAG 2 -- int11Minor allele frequency- G:0.04NS 114

    HapMap Linkage Disequilibrium report for USP5 (6961285 - 6975796 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for USP5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898642CNV Loss21882294
    nsv898641CNV Loss21882294
    dgv1353n71CNV Loss21882294
    nsv832323CNV Loss17160897
    nsv832324CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP5
    DNA2.0 Custom Variant and Variant Library Synthesis for USP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601447    OMIM disorders: --


    Find genes that share disorders with USP5           About GenesLikeMe


    Export disorders for USP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP5 gene, integrated from 10 sources (see all 84):
    (articles sorted by number of sources associating them with USP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. (PubMed id 8723724)1, 2, 3, 9 Ansari-Lari M.A.... Gibbs R.A. (Genome Res. 1996)
    2. The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. (PubMed id 16564012)1, 2, 9 Reyes-Turcu F.E....Wilkinson K.D. (Cell 2006)
    3. Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T. (PubMed id 18482987)1, 2, 9 Reyes-Turcu F.E.... Wilkinson K.D. (J. Biol. Chem. 2008)
    4. Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53. (PubMed id 19098288)1, 2, 9 Dayal S....Saville M.K. (J. Biol. Chem. 2009)
    5. Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin. (PubMed id 22216260)1, 2 Zhang Y.H.... Hu H.Y. (PLoS ONE 2011)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    9. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. (PubMed id 9074930)1, 2 Ansari-Lari M.A.... Gibbs R.A. (Genome Res. 1997)
    10. cDNA cloning of a human 100 kDa de-ubiquitinating enzyme: the 100 kDa human de-ubiquitinase belongs to the ubiquitin C-terminal hydrolase family 2 (UCH2). (PubMed id 7498549)1, 2 Falquet L....Jaton J.-C. (FEBS Lett. 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8078 HGNC: 12628 AceView: USP5 Ensembl:ENSG00000111667 euGenes: HUgn8078
    ECgene: USP5 H-InvDB: USP5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for USP5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for USP5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP5 gene:
    Search GeneIP for patents involving USP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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