USP49 Gene
protein-coding GIFtS: 48
GCID: GC06M041762
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ubiquitin specific peptidase 49(Previous name: ubiquitin specific protease 49 )
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Aliases
for USP49 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 491 2 | | MGC207411 | | Ubiquitin Specific Protease 491 2 | | Ubiquitin Carboxyl-Terminal Hydrolase 492 | | Deubiquitinating Enzyme 492 3 | | Ubiquitin Thiolesterase 492 | | Ubiquitin Thioesterase 492 3 | | EC 3.4.19.123 | | Ubiquitin-Specific-Processing Protease 492 3 | | EC 3.1.2.158 |
Export aliases for USP49 gene to outside databasesPrevious GC identifers: GC06M041874 GC06M041919 GC06M041981 GC06M041876 GC06M041484 |
Summaries
for USP49 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for USP49 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP49 gene promoter:
Sp1 GCNF MyoD NF-kappaB HNF-1A FAC1 GCNF-1 HNF-1 NF-kappaB1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP49
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP49 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p12.1USP49 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M041762: view genomic region
(about GC identifiers)
Start:
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41,762,107 bp from pter |
End:
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41,863,099 bp from pter |
Size:
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100,993 bases |
Orientation:
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minus strand |
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Proteins
for USP49 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP49_HUMAN, Q70CQ1 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 49 Size: 688 amino acids; 79198 Da
Secondary accessions: Q5T3D9 Q5T3E0 Q96CK4Alternative splicing: 2 isoforms: Q70CQ1-1 Q70CQ1-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for USP49: NX_Q70CQ1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q70CQ1
2 DME Specific Peptides for USP49 (Q70CQ1)
USP49 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061031.2
ENSEMBL proteins: ENSP00000377797 ENSP00000362101 ENSP00000389842 ENSP00000362097 ENSP00000410003 ENSP00000411603 ENSP00000362100 ENSP00000297229
Human Recombinant Protein Products for USP49:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
USP49 for ontologies About GeneDecksing
USP49 Antibody Products:
Assay Products for USP49: |
Protein
Domains /
Families
for USP49 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP49 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q70CQ1ProtoNet protein and cluster: Q70CQ1 2 Blocks protein families: IPB001394 Ubiquitin thiolesterase IPB001607 Zn-finger in ubiquitin thiolesterase
UniProtKB/Swiss-Prot: UBP49_HUMAN, Q70CQ1Similarity: Belongs to the peptidase C19 familySimilarity: Contains 1 UBP-type zinc finger |
Function
for USP49 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: UBP49_HUMAN, Q70CQ1Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004221 | ubiquitin thiolesterase activity |
IEA | -- | | GO:0008234 | cysteine-type peptidase activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
USP49 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for USP49:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP49 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP49
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: USP49 (NM_018561) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP49 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP49 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP49 |
|
Pathways & Interactions
for USP49 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP49
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/42 Interacting proteins for USP49 (Q70CQ13 ENSP000002972294) via UniProtKB, MINT, STRING, and/or I2D (see all 42)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- |
USP49 for ontologies About GeneDecksing
|
Drugs & Compounds
for USP49 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USP49
Search CenterWatch for drugs/clinical trials and news about USP49 / UBP49
|
Transcripts
for USP49 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP49 gene: NM_018561.3 Unigene Cluster for USP49: Ubiquitin specific peptidase 49 Hs.665742 [show with all ESTs]Unigene Representative Sequence: NM_0185618 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000394253 ENST00000373010 ENST00000448078 ENST00000373006(uc003ori.3)
ENST00000437061 ENST00000423567 ENST00000373009 ENST00000297229
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP49 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP49
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: USP49 (NM_018561) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP49 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP49 |
Additional cDNA sequence: AF119901.2 AJ586139.1 AL049937.1 BC014176.2 5 DOTS entries: DT.92044269 DT.91742370 DT.102825898 DT.75125613 DT.439199 24/226 AceView cDNA sequences (see all 226): BC033498 AA353918 BM800534 BM711328 BM767272 NM_018561 BM770537 F13789 BM819180 CR603210 BE501954 AI800301 BF727345 BM767240 CA314319 BM766837 BX090024 AA872083 CA426795 CA423270 BC014176 BM768031 BM747983 AA877415
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for USP49 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b |
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| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for USP49
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Expression
for USP49 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP49 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTAAACCCC
About this image
See USP49 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP49
SOURCE GeneReport for Unigene cluster: Hs.665742
SABiosciences Custom PCR Arrays for USP49
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP49
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP49 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP49 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP49 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP49 |
Orthologs
for USP49 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for USP49 gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for USP49 (if available)
TreeFam Gene Tree for USP49 (if available) |
Paralogs
for USP49 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP49 gene
- USP332 USP32 USP442 USP452 USP222 USP512 USP162 USP202
1 SIMAP similar gene for USP49 using alignment to 5 protein entries: UBP49_HUMAN (see all proteins):USP44
USP49 for paralogs About GeneDecksing
|
Genomic Variants
for USP49 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP49 (41762107 - 41863099 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for USP49: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP49 |
|
Disorders
/ Diseases
for USP49 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP49 for disorders About GeneDecksing
1  disease for USP49: About MalaCardsmalaria
Export disorders for USP49 gene to outside databases
|
Publications
for USP49 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USP49 gene integrated from 9 sources:
(articles sorted by number of sources associating them with USP49) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2, 3 Quesada V.... Lopez-Otin C. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. (PubMed id 14576168)1 Sato S.... Conaway J.W. (2003)
- Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PubMed id 12584197)1 Sato S....Conaway J.W. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for USP49 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing USP49 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USP49 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing USP49 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for USP49 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for USP49 gene:
Search GeneIP for patents involving USP49
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for USP49 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for USP49 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP49 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP49 | | | OriGene Protein Over-expression Lysate for USP49 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for USP49 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP49 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP49 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for USP49 | | OriGene Custom Protein Services for USP49 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP49 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP49 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP49 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP49 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP49 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP49 |
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| | | | Search Tocris compounds for USP49 |
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 | | | USP49 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP49 |
|  |  |  |  | | | | ThermoFisher Antibodies for USP49 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP49 |
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