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Aliases for USP49 Gene

Aliases for USP49 Gene

  • Ubiquitin Specific Peptidase 49 2 3
  • Ubiquitin-Specific-Processing Protease 49 4
  • Ubiquitin Specific Protease 49 2
  • Deubiquitinating Enzyme 49 4
  • Ubiquitin Thioesterase 49 4
  • EC 3.4.19.12 4
  • EC 3.1.2.15 63

External Ids for USP49 Gene

Previous GeneCards Identifiers for USP49 Gene

  • GC06M041874
  • GC06M041919
  • GC06M041981
  • GC06M041876
  • GC06M041762
  • GC06M041484
  • GC06M041787

Summaries for USP49 Gene

GeneCards Summary for USP49 Gene

USP49 (Ubiquitin Specific Peptidase 49) is a Protein Coding gene. GO annotations related to this gene include ubiquitin thiolesterase activity and cysteine-type endopeptidase activity. An important paralog of this gene is USP50.

UniProtKB/Swiss-Prot for USP49 Gene

  • Specifically deubiquitinates histone H2B at Lys-120 (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP49 Gene

Genomics for USP49 Gene

Regulatory Elements for USP49 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for USP49 Gene

Start:
41,789,896 bp from pter
End:
41,895,361 bp from pter
Size:
105,466 bases
Orientation:
Minus strand

Genomic View for USP49 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP49 Gene

Proteins for USP49 Gene

  • Protein details for USP49 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70CQ1-UBP49_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 49
    Protein Accession:
    Q70CQ1
    Secondary Accessions:
    • Q5T3D9
    • Q5T3E0
    • Q96CK4

    Protein attributes for USP49 Gene

    Size:
    688 amino acids
    Molecular mass:
    79198 Da
    Quaternary structure:
    • Component of a complex with RUVBL1 and PSMC5.

    Alternative splice isoforms for USP49 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP49 Gene

Proteomics data for USP49 Gene at MOPED

Selected DME Specific Peptides for USP49 Gene

Post-translational modifications for USP49 Gene

  • Ubiquitination at Lys522
  • Modification sites at PhosphoSitePlus

Other Protein References for USP49 Gene

Domains for USP49 Gene

Gene Families for USP49 Gene

HGNC:
  • USP :Ubiquitin-specific peptidases

Suggested Antigen Peptide Sequences for USP49 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q70CQ1

UniProtKB/Swiss-Prot:

UBP49_HUMAN :
  • Q70CQ1
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
Similarity:
  • Contains 1 UBP-type zinc finger.
genes like me logo Genes that share domains with USP49: view

Function for USP49 Gene

Molecular function for USP49 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function: Specifically deubiquitinates histone H2B at Lys-120 (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.

Enzyme Numbers (IUBMB) for USP49 Gene

Gene Ontology (GO) - Molecular Function for USP49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IMP 23824326
GO:0004221 ubiquitin thiolesterase activity --
GO:0004843 ubiquitin-specific protease activity IDA 14715245
GO:0005515 protein binding IPI 19615732
GO:0008234 cysteine-type peptidase activity --
genes like me logo Genes that share ontologies with USP49: view

Phenotypes for USP49 Gene

GenomeRNAi human phenotypes for USP49:
genes like me logo Genes that share phenotypes with USP49: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for USP49 Gene

Localization for USP49 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP49 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP49 Gene COMPARTMENTS Subcellular localization image for USP49 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for USP49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with USP49: view

Pathways for USP49 Gene

SuperPathways for USP49 Gene

No Data Available

Interacting Proteins for USP49 Gene

Gene Ontology (GO) - Biological Process for USP49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IMP 23824326
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0016579 protein deubiquitination IDA 14715245
GO:0035616 histone H2B conserved C-terminal lysine deubiquitination IDA 23824326
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with USP49: view

No data available for Pathways by source for USP49 Gene

Transcripts for USP49 Gene

Unigene Clusters for USP49 Gene

Ubiquitin specific peptidase 49:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP49

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP49 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for USP49 Gene

GeneLoc Exon Structure for
USP49
ECgene alternative splicing isoforms for
USP49

Expression for USP49 Gene

mRNA expression in normal human tissues for USP49 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for USP49 Gene

SOURCE GeneReport for Unigene cluster for USP49 Gene Hs.665742

genes like me logo Genes that share expressions with USP49: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for USP49 Gene

Orthologs for USP49 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP49 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP49 35
  • 99.76 (n)
  • 99.85 (a)
USP49 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia USP49 35
  • 89.82 (n)
  • 92.07 (a)
USP49 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP49 35
  • 90.88 (n)
  • 92.21 (a)
USP49 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp49 35
  • 90.16 (n)
  • 90.94 (a)
Usp49 16
Usp49 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia USP49 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP49 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp49 35
  • 88.94 (n)
  • 90.06 (a)
chicken
(Gallus gallus)
Aves USP49 35
  • 76.57 (n)
  • 81.28 (a)
USP49 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP49 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp49 35
  • 67.87 (n)
  • 76.02 (a)
zebrafish
(Danio rerio)
Actinopterygii usp49 35
  • 66.45 (n)
  • 68.45 (a)
usp49 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea E01B7.1 36
  • 12 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DOA4 36
  • 13 (a)
ManyToMany
UBP5 36
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for USP49:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP49 Gene

ENSEMBL:
Gene Tree for USP49 (if available)
TreeFam:
Gene Tree for USP49 (if available)

Paralogs for USP49 Gene

Paralogs for USP49 Gene

Selected SIMAP similar genes for USP49 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with USP49: view

Variants for USP49 Gene

Sequence variations from dbSNP and Humsavar for USP49 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1192238 -- 41,836,098(+) CAATA(C/T)AAATT intron-variant
rs1192239 -- 41,841,413(+) ACTCT(A/G)AGCTT intron-variant
rs1192240 -- 41,877,582(+) ttttt(G/T)gagac intron-variant
rs1192241 -- 41,883,227(+) cacac(A/G)cctgt intron-variant
rs1192242 -- 41,883,455(+) agttc(A/G)aaacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP49 Gene

Variant ID Type Subtype PubMed ID
nsv885833 CNV Loss 21882294

Relevant External Links for USP49 Gene

HapMap Linkage Disequilibrium report
USP49

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP49 Gene

Disorders for USP49 Gene

Relevant External Links for USP49

Genetic Association Database (GAD)
USP49
genes like me logo Genes that share disorders with USP49: view

No data available for UniProtKB/Swiss-Prot for USP49 Gene

Publications for USP49 Gene

  1. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. (PMID: 23824326) Zhang Z. … Wang H. (Genes Dev. 2013) 3 4
  4. Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling. (PMID: 25391492) Lamoliatte F. … Thibault P. (Nat Commun 2014) 3
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4

Products for USP49 Gene

  • Addgene plasmids for USP49

Sources for USP49 Gene

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