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USP49 Gene

protein-coding   GIFtS: 50
GCID: GC06M041795

Ubiquitin Specific Peptidase 49

(Previous name: ubiquitin specific protease 49)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 491 2     Ubiquitin Carboxyl-Terminal Hydrolase 492
Ubiquitin Specific Protease 491 2     Ubiquitin Thiolesterase 492
Deubiquitinating Enzyme 492 3     EC 3.4.19.123
Ubiquitin Thioesterase 492 3     EC 3.1.2.158
Ubiquitin-Specific-Processing Protease 492 3     

External Ids:    HGNC: 200781   Entrez Gene: 258622   Ensembl: ENSG000001646637   UniProtKB: Q70CQ13   

Export aliases for USP49 gene to outside databases

Previous GC identifers: GC06M041874 GC06M041919 GC06M041981 GC06M041876 GC06M041762 GC06M041484 GC06M041787


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for USP49 Gene:
USP49 (ubiquitin specific peptidase 49) is a protein-coding gene. GO annotations related to this gene include cysteine-type endopeptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP3.

UniProtKB/Swiss-Prot: UBP49_HUMAN, Q70CQ1
Function: Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for
epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for
efficient cotranscriptional splicing of a large set of exons




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP49 gene promoter:
         Sp1   GCNF   MyoD   NF-kappaB   HNF-1A   FAC1   GCNF-1   HNF-1   NF-kappaB1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP49 promoter sequence
   Search Chromatin IP Primers for USP49

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP49


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p12.1

USP49 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP49 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M041795:  view genomic region     (about GC identifiers)

Start:
41,757,634 bp from pter      End:
41,863,099 bp from pter
Size:
105,466 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBP49_HUMAN, Q70CQ1 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 49  
Size: 688 amino acids; 79198 Da
Subunit: Component of a complex with RUVBL1 and PSMC5
Secondary accessions: Q5T3D9 Q5T3E0 Q96CK4
Alternative splicing: 2 isoforms:  Q70CQ1-1   Q70CQ1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP49: NX_Q70CQ1

Explore proteomics data for USP49 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys522
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for USP49 (Q70CQ1)
     QQDAQEFL  NLGNTCYMN 


    See USP49 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273483.1  NP_061031.2  

    ENSEMBL proteins: 
     ENSP00000377797   ENSP00000362101   ENSP00000389842   ENSP00000362097   ENSP00000410003  
     ENSP00000411603   ENSP00000362100   ENSP00000297229  

    USP49 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for USP49
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    Novus Biologicals USP49 Proteins
    Novus Biologicals USP49 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP49

     
    Search eBioscience for Proteins for USP49 

     
    antibodies-online proteins for USP49 (6 products) 

     
    antibodies-online peptides for USP49

    USP49 Antibody Products:

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    antibodies-online antibodies for USP49 (12 products) 

    USP49 Assay Products:

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    Cloud-Clone Corp. ELISAs for USP49
    Cloud-Clone Corp. CLIAs for USP49
    Search eBioscience for ELISAs for USP49 
    antibodies-online kits for USP49 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    5 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR013083 Znf_RING/FYVE/PHD
     IPR028889 UCH/PAN2
     IPR001607 Znf_UBP

    Graphical View of Domain Structure for InterPro Entry Q70CQ1

    ProtoNet protein and cluster: Q70CQ1

    2 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB001607 Zn-finger in ubiquitin thiolesterase


    UniProtKB/Swiss-Prot: UBP49_HUMAN, Q70CQ1
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 UBP-type zinc finger
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP49           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP49_HUMAN, Q70CQ1
    Function: Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for
    epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for
    efficient cotranscriptional splicing of a large set of exons
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IMP--
    GO:0004221ubiquitin thiolesterase activity IDA--
    GO:0004843ubiquitin-specific protease activity IDA14715245
    GO:0005515protein binding IPI--
    GO:0008234cysteine-type peptidase activity ----
         
    Find genes that share ontologies with USP49           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for USP49:
     Increased S DNA content  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for USP49

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate USP49 (see all 11):
    hsa-miR-411* hsa-miR-1290 hsa-miR-379* hsa-miR-3138 hsa-miR-3692 hsa-miR-567 hsa-miR-544 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidUSP49 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for USP49
    Predesigned siRNA for gene silencing in human, mouse, rat USP49

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for USP49

    Clone
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    OriGene clones in human, mouse for USP49 (see all 6)
    OriGene ORF clones in mouse, rat for USP49
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    GenScript: all cDNA clones in your preferred vector: USP49 (NM_018561)
    Sino Biological Human cDNA Clone for USP49
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP49
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP49
    Addgene plasmids for USP49 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP49


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBP49_HUMAN, Q70CQ1: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----

    Find genes that share ontologies with USP49           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP49
    Interactions:

        Search GeneGlobe Interaction Network for USP49

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP49 (Q70CQ13 ENSP000002972294) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000229802Q925043, ENSP000003917354I2D: score=2 STRING: ENSP00000391735
    SLC39A7Q925043, ENSP000003638074I2D: score=2 STRING: ENSP00000363807
    ENSG00000206288Q925043I2D: score=2 
    ENSG00000224399Q925043I2D: score=2 
    ENSG00000226614Q925043I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IMP--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016579protein deubiquitination IDA14715245
    GO:0035616histone H2B conserved C-terminal lysine deubiquitination IDA--

    Find genes that share ontologies with USP49           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP49 (UBP49)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP49 gene (2 alternative transcripts): 
    NM_001286554.1  NM_018561.4  

    Unigene Cluster for USP49:

    Ubiquitin specific peptidase 49
    Hs.665742  [show with all ESTs]
    Unigene Representative Sequence: NM_018561
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394253 ENST00000373010 ENST00000448078 ENST00000373006(uc003ori.3)
    ENST00000437061 ENST00000423567 ENST00000373009 ENST00000297229
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP49 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP49 (see all 11):
    hsa-miR-411* hsa-miR-1290 hsa-miR-379* hsa-miR-3138 hsa-miR-3692 hsa-miR-567 hsa-miR-544 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidUSP49 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat USP49
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP49 (NM_018561)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP49
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP49
    Addgene plasmids for USP49 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for USP49
    OriGene qSTAR qPCR primer pairs in human, mouse for USP49
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP49
      QuantiTect SYBR Green Assays in human, mouse, rat USP49
      QuantiFast Probe-based Assays in human, mouse, rat USP49

    Additional mRNA sequence: 

    AF119901.2 AJ586139.1 AL049937.1 BC014176.2 

    5 DOTS entries:

    DT.92044269  DT.91742370  DT.102825898  DT.75125613  DT.439199 

    Selected AceView cDNA sequences (see all 226):

    AA877415 AA872083 T30294 BM768061 NM_018561 BM770675 AW237796 BM772202 
    BC033498 BE501954 BM771474 BQ670725 BM905102 AJ586139 BM767313 BM766485 
    BF727345 AI140920 BM770783 AA353918 BM476769 BC014176 BQ712535 CA426795 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for USP49    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:              -                           


    ECgene alternative splicing isoforms for USP49

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP49 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTAAACCCC
    USP49 Expression
    About this image


    USP49 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    USP49 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP49 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.665742
        Custom PCR Arrays for USP49
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP49

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP49 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp491 , 5 ubiquitin specific peptidase 491, 5 90.16(n)1
    90.94(a)1
      17 (23.72 cM)5
    2248361  NM_198421.11  NP_940813.11 
     476306905 
    chicken
    (Gallus gallus)
    Aves USP491 ubiquitin specific peptidase 49 76.57(n)
    81.28(a)
      419925  XM_001231681.3  XP_001231682.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP496
    ubiquitin specific peptidase 49
    73(a)
    1 ↔ 1
    4(119342979-119350503)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia usp491 ubiquitin specific peptidase 49 67.87(n)
    76.02(a)
      100488823  XM_004910676.1  XP_004910733.1 
    zebrafish
    (Danio rerio)
    Actinopterygii usp491 ubiquitin specific peptidase 49 66.45(n)
    68.45(a)
      559473  NM_001044896.1  NP_001038361.1 
    worm
    (Caenorhabditis elegans)
    Secernentea E01B7.16
    Protein E01B7.1 (E01B7.1) mRNA, complete cds
    12(a)
    many ↔ many
    V(17924916-17934227) WBGene00008441
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP56
    DOA46
    Putative ubiquitin-specific protease, closest para...
    Ubiquitin isopeptidase, required for recycling ubi...
    15(a)
    13(a)
    many ↔ many
    many ↔ many
    V(457806-460223) YER144C
    IV(584939-587719) YDR069C


    ENSEMBL Gene Tree for USP49 (if available)
    TreeFam Gene Tree for USP49 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP49 gene
    USP32  USP442  USP212  USP82  USP22  USP502  
    1 SIMAP similar gene for USP49 using alignment to 5 protein entries:     UBP49_HUMAN (see all proteins):
    USP44

    Find genes that share paralogs with USP49           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP49 (see all 1810)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1811380201,2
    --41764889(+) GAGACA/GGGGCT 1 -- int10--------
    rs1839172471,2
    --41764891(+) GACGGA/GGCTTC 1 -- int10--------
    rs1500289601,2
    C--41764980(+) GGCGTA/GAGCCA 1 -- int10--------
    rs1453627381,2
    --41764993(+) GCACCC/TAGCCG 1 -- int10--------
    rs1176505941,2
    C,F--41764997(+) CCAGCC/TGACTG 1 -- int11Minor allele frequency- T:0.04EA 120
    rs1881953211,2
    --41765058(+) GCCTTC/GTAGAA 1 -- int10--------
    rs745251581,2
    F--41765059(+) CCTTCT/CAGAAA 1 -- int12Minor allele frequency- C:0.10CSA WA 120
    rs18914531,2
    C,F,A,H--41765265(+) GTCAGT/CGCAGT 1 -- int118Minor allele frequency- C:0.17NS EA NA 2226
    rs168950201,2
    C,F,H--41765419(+) CTAGTG/AAGATT 1 -- ut31 ese314Minor allele frequency- A:0.02NA NS EA WA 1626
    rs776161801,2
    F--41765571(+) TAACAC/GTGACT 1 -- ut311Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for USP49 (41757634 - 41863099 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for USP49:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv885833CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP49
    DNA2.0 Custom Variant and Variant Library Synthesis for USP49

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with USP49           About GenesLikeMe

    Genetic Association Database (GAD): USP49

    Export disorders for USP49 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP49 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with USP49)
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    1. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2, 3 Quesada V.... Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004)
    2. USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. (PubMed id 23824326)1, 2 Zhang Z....Wang H. (amp 2013)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. (PubMed id 23263863)1 Li J....Sleiman P.M. (Hum. Mol. Genet. 2013)
    5. Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. (PubMed id 23105109)1 Hayes S.D....UrbAc S. (J. Biol. Chem. 2012)
    6. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PubMed id 20139978)1 Kamatani Y....Kamatani N. (Nat. Genet. 2010)
    7. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25862 HGNC: 20078 AceView: USP49andMGC20741 Ensembl:ENSG00000164663 euGenes: HUgn25862
    ECgene: USP49 H-InvDB: USP49

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP49 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP49 gene:
    Search GeneIP for patents involving USP49

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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