Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP47 Gene

protein-coding   GIFtS: 51
GCID: GC11P011819

ubiquitin specific peptidase 47

(Previous names: Trf (TATA binding protein-related factor)-proximal homolog...)
  Search for USP47
in our new
 Human Malady Compendium 
Biological research products
for USP47
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 471 2     TRFP2
Ubiquitin Specific Protease 471 2     Trf (TATA Binding Protein-Related Factor)-Proximal Homolog2
Deubiquitinating Enzyme 472 3     Ubiquitin Carboxyl-Terminal Hydrolase 472
Ubiquitin Thioesterase 472 3     Ubiquitin Thiolesterase 472
Ubiquitin-Specific-Processing Protease 472 3     EC 3.4.19.123
Trf (TATA Binding Protein-Related Factor)-Proximal Homolog (Drosophila)1     

External Ids:    HGNC: 200761   Entrez Gene: 550312   Ensembl: ENSG000001702427   OMIM: 6144605   UniProtKB: Q96K763   

Export aliases for USP47 gene to outside databases

Previous GC identifers: GC11P011902 GC11P011827 GC11P011538


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: UBP47_HUMAN, Q96K76
Function: Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB),
stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome
integrity. May also indirectly regulates CDC25A expression at a transcriptional level

Gene Wiki entry for USP47


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP47 gene promoter:
         Lmo2   FOXD3   HNF-3beta   GATA-1   HNF-1A   Egr-2   GATA-6   HNF-1   Sox9   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): USP47 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP47

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP47


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.3   Ensembl cytogenetic band:  11p15.3   HGNC cytogenetic band: 11p15.2

USP47 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP47 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P011819:  view genomic region     (about GC identifiers)

Start:
11,862,970 bp from pter      End:
11,980,872 bp from pter
Size:
117,903 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UBP47_HUMAN, Q96K76 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 47  
Size: 1375 amino acids; 157311 Da
Subunit: Interacts with BTRC and FBXW11. Interacts with POLB
Subcellular location: Cytoplasm
Caution: Was initially thought to catalytically inactive (PubMed:14715245). However, it was later shown that it is
active (PubMed:21362556)
Sequence caution: Sequence=BAA91348.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KXF5 Q658U0 Q86Y73 Q8TEP6 Q9BWI0 Q9NWN1
Alternative splicing: 3 isoforms:  Q96K76-1   Q96K76-2   Q96K76-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP47: NX_Q96K76

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96K76

  • USP47 Protein expression data from MOPED and PaxDb:    About this image 
    USP47 Protein Expression
    REFSEQ proteins: NP_060414.3  
    ENSEMBL proteins: 
     ENSP00000339957   ENSP00000436894   ENSP00000433146   ENSP00000382382   ENSP00000440405  

    Human Recombinant Protein Products for USP47: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: USP47
    OriGene Custom Protein Services for USP47 
    GenScript Custom Purified and Recombinant Proteins Services for USP47
    Novus Biologicals USP47 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for USP47

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0019005SCF ubiquitin ligase complex IDA19966869

    USP47 for ontologies           About GeneDecksing



    USP47 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: USP47
    OriGene Custom Antibody Services for USP47 
    GenScript Custom Superior Antibodies Services for USP47
    Novus Biologicals USP47 Antibodies
    Abcam antibodies for USP47 
    Uscn Antibodies for USP47
    ThermoFisher Antibody for USP47

    Assay Products for USP47: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP47
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for USP47


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    USP47 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS

    Graphical View of Domain Structure for InterPro Entry Q96K76

    ProtoNet protein and cluster: Q96K76

    1 Blocks protein family: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP47_HUMAN, Q96K76
    Similarity: Belongs to the peptidase C19 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP47_HUMAN, Q96K76
    Function: Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB),
    stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome
    integrity. May also indirectly regulates CDC25A expression at a transcriptional level
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the
    C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IEA--
    GO:0004843ubiquitin-specific protease activity IDA--
    GO:0005515protein binding IPI--
    GO:0008234cysteine-type peptidase activity ----
    GO:0071987WD40-repeat domain binding IPI19966869
         
    USP47 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Usp47):
     cellular 

    USP47 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for USP47 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: USP47
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP47
    8/127 QIAGEN miScript miRNA Assays for microRNAs that regulate USP47 (see all 127):
    hsa-miR-124* hsa-miR-411* hsa-miR-26a-2* hsa-miR-188-5p hsa-miR-146a hsa-miR-30d hsa-miR-374a hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidUSP47 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP47 (see all 7)
    OriGene shRNA RFP: USP47
    OriGene siRNA: USP47
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP47
    Sirion Biotech Custom design and validation of potent shRNA sequences against USP47 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP47
    Sirion Biotech Customized adenovirus for overexpression of USP47 
    Sirion Biotech Customized adenovirus for potent knockdown of USP47

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP47 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP47
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: USP47 (NM_017944)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP47
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP47 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for USP47
    Search LifeMap BioReagents cell lines for USP47
    Sirion Biotech Customized stable knockdown cell line services for USP47 
    Sirion Biotech Customized inducible knockdown cell line services for USP47
    Sirion Biotech Customized stable overexpressing cell line services for USP47
    Sirion Biotech Customized inducible overexpressing cell line services for USP47

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP47


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis1.00

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP47
        Ubiquitin-Proteasome Dependent Proteolysis


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP47

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for USP47 (Q96K763 ENSP000003399574) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTRCQ9Y2973, ENSP000003592064I2D: score=2 STRING: ENSP00000359206
    FBXW11Q9UKB13, ENSP000002650944I2D: score=2 STRING: ENSP00000265094
    MED29Q9NX703, ENSP000003143434I2D: score=1 STRING: ENSP00000314343
    MED9Q9NWA03, ENSP000002687114I2D: score=1 STRING: ENSP00000268711
    SEP15O606133I2D: score=5 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006284base-excision repair IMP--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006974response to DNA damage stimulus IMP--
    GO:0010972negative regulation of G2/M transition of mitotic cell cycle IMP19966869
    GO:0030307positive regulation of cell growth IMP19966869

    USP47 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP47

    1 HMDB Compound for USP47    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about USP47 / UBP47 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP47 gene: 
    NM_017944.3  

    Unigene Cluster for USP47:

    Ubiquitin specific peptidase 47
    Hs.577256  [show with all ESTs]
    Unigene Representative Sequence: NM_017944
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339865(uc001mjq.1 uc001mjr.3 uc001mjs.3) ENST00000525257
    ENST00000525267 ENST00000527733 ENST00000399455(uc009ygi.3) ENST00000525367
    ENST00000525078 ENST00000531513 ENST00000530041 ENST00000530369 ENST00000305481
    ENST00000529813 ENST00000539466(uc001mjt.1)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: USP47
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP47
    8/127 QIAGEN miScript miRNA Assays for microRNAs that regulate USP47 (see all 127):
    hsa-miR-124* hsa-miR-411* hsa-miR-26a-2* hsa-miR-188-5p hsa-miR-146a hsa-miR-30d hsa-miR-374a hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidUSP47 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP47 (see all 7)
    OriGene shRNA RFP: USP47
    OriGene siRNA: USP47
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP47
    Sirion Biotech Custom design and validation of potent shRNA sequences against USP47 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP47 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP47
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: USP47 (NM_017944)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP47
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP47 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP47
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP47
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP47
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP47

    Additional cDNA sequence: 

    AB073355.1 AF059318.1 AK000734.1 AK027283.1 AK027362.1 AK074076.1 AK092290.1 AK093714.1 
    AK127264.1 AK225358.1 AL832991.2 BC000226.1 BC017795.1 BC030562.1 BC047044.1 BC071559.1 

    20 DOTS entries:

    DT.40196938  DT.100819188  DT.97779608  DT.99941076  DT.100819186  DT.95275974  DT.120734868  DT.40108888 
    DT.100819187  DT.120734790  DT.75162034  DT.92442587  DT.95275978  DT.99955310  DT.100819190  DT.86852533 
    DT.91736526  DT.92442592  DT.120734789  DT.95275975 

    24/263 AceView cDNA sequences (see all 263):

    AW103221 AA737766 AI672221 AI633767 CB215171 BU542376 AI080371 BF437799 
    CA397431 AA721349 BE551846 BM797971 AA652971 BP380374 AI225125 BE463882 
    AA634250 AK027283 BI254736 AA037814 AX747455 AI276944 BM683122 AI824461 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for USP47 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ·
    SP1:                    -     -     -           -                                                                                                               
    SP2:                                            -                                                                                                               
    SP3:                                                                                                                                                            
    SP4:                    -                       -                                                                                                               
    SP5:                                                                                                                                                            

    ExUns: 21c ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31
    SP1:        -                 -           -                             -     -                           
    SP2:                                                                                                      
    SP3:                                                                    -                                 
    SP4:                                                                                                      
    SP5:                          -           -                                                               


    ECgene alternative splicing isoforms for USP47

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP47 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGTGCACTA
    USP47 Expression
    About this image
    See USP47 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP47

    SOURCE GeneReport for Unigene cluster: Hs.577256

    UniProtKB/Swiss-Prot: UBP47_HUMAN, Q96K76
    Tissue specificity: Expressed in skeletal muscle, heart and testis

        SABiosciences Custom PCR Arrays for USP47
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP47
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP47
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP47
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP47
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP47

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for USP47 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves USP471 ubiquitin specific peptidase 47 83.5(n)
    91.12(a)
      423032  NM_001199582.1  NP_001186511.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP476
    --
    82(a)
    1 ↔ 1
    GL343237.1(486362-541951)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL852749.22   -- 75.12(n)    AL852749.2 
    zebrafish
    (Danio rerio)
    Actinopterygii CF265902.12   -- 75.14(n)    CF265902.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ubp64E1 Ubiquitin-specific protease 64E 47.05(n)
    41.92(a)
      38644  NM_206279.2  NP_996001.2 
    worm
    (Caenorhabditis elegans)
    Secernentea T05H10.11 Protein T05H10.1 45.77(n)
    35.02(a)
      174290  NM_063285.5  NP_495686.2 


    ENSEMBL Gene Tree for USP47 (if available)
    TreeFam Gene Tree for USP47 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP47 gene
    USP242  USP182  USP412  USP482  USP402  USP72  USP9Y2  USP342  
    USP9X2  
    2 SIMAP similar genes for USP47 using alignment to 4 protein entries:     UBP47_HUMAN (see all proteins):
    DKFZp686C13257    USP40

    USP47 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1790 NCBI SNPs in USP47 are shown (see all 1790    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs102192281,2
    C,F,H--11656279(+) TTCTAA/GGGCGG 1 -- us2k1 ese311Minor allele frequency- G:0.10NS EA NA WA 1214
    rs1178140701,2
    C,F--11656301(+) NNNNGG/ATGCAT 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs758166121,2
    F--11656307(+) TGCATT/ACTGGC 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1113330621,2
    --11656362(+) TGATCT/AGTACG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs561460671,2
    --11656874(+) TTTGTG/TTGCTG 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs784326381,2
    --11657142(+) GAGGGA/GGGCTG 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs579367911,2
    C--11657227(+) CATGCA/GTTGGA 1 -- us2k12Minor allele frequency- G:0.18WA 120
    rs618706741,2
    --11861170(+) TCTTTC/TTATAT 1 -- us2k10--------
    rs1911330741,2
    --11861208(+) AATCTA/TACTTA 1 -- us2k10--------
    rs1456397461,2
    --11861487(+) TGACAC/TTTTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for USP47 (11862970 - 11980872 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for USP47
         2 CNVs: 0144 85656
         3 Indels: 33541 33236 65869

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP47
    DNA2.0 Custom Variant and Variant Library Synthesis for USP47

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    USP47 for disorders           About MalaCards

    USP47 for disorders           About GeneDecksing

    OMIM gene information: 614460    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: USP47 (1 document)

    Export disorders for USP47 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP47 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with USP47)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA Polymerase beta. (PubMed id 21362556)1, 2 Parsons J.L.... Dianov G.L. (2011)
    2. The ubiquitin-specific protease USP47 is a novel beta -TRCP interactor regulating cell survival. (PubMed id 19966869)1, 2 Peschiaroli A....Melino G. (2010)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (2004)
    7. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    8. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
    9. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55031 HGNC: 20076 AceView: USP47 Ensembl:ENSG00000170242 euGenes: HUgn55031
    ECgene: USP47 H-InvDB: USP47

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP47 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP47 gene:
    Search GeneIP for patents involving USP47

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for USP47   OriGene shRNA RFP for USP47  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP47   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP47  
     OriGene Protein Over-expression Lysate for USP47   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for USP47   OriGene 3'-UTR Clone for USP47  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP47   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP47  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for USP47   OriGene Custom Protein Services for USP47  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP47
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP47
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP47
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP47
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP47
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP47
     GenScript Custom Purified and Recombinant Proteins Services for USP47 GenScript cDNA clones with any tag delivered in your preferred vector for USP47
     GenScript Custom Assay Services for USP47 GenScript Custom Superior Antibodies Services for USP47
     GenScript Custom overexpressing Cell Line Services for USP47 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in USP47 promoter
     Search Chromatin IP Primers for USP47
     RT2 qPCR Primer Assay in human, mouse, rat USP47
     Search GNC Networks for USP47
     SABiosciences PCR Arrays including human, mouse, rat USP47
     Search Tocris compounds for USP47
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     USP47 antibodies
     USP47 proteins
     Antibodies for USP47
     See all of Abcam's Antibodies, Kits and Proteins for USP47
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     USP47 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for USP47
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP47
     SwitchGear 3'UTR luciferase reporter plasmids for USP47
     SwitchGear Promoter luciferase reporter plasmids for USP47
     ThermoFisher Antibody for USP47
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP47
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for USP47
    Sirion Biotech Customized:
     stable knockdown cell line services for USP47
     inducible knockdown cell line services for USP47
     design and validation of potent shRNA sequences against USP47
     adenovirus for potent knockdown of USP47
     adenovirus for overexpression of USP47
     stable overexpressing cell line services for USP47
     inducible overexpressing cell line services for USP47
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      USP47 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4