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Aliases for USP45 Gene

Aliases for USP45 Gene

  • Ubiquitin Specific Peptidase 45 2 3 5
  • Ubiquitin-Specific-Processing Protease 45 4
  • Ubiquitin Specific Protease 45 2
  • Deubiquitinating Enzyme 45 4
  • Ubiquitin Thioesterase 45 4
  • EC 3.4.19.12 4
  • EC 3.1.2.15 56

External Ids for USP45 Gene

Previous GeneCards Identifiers for USP45 Gene

  • GC06M099880
  • GC06M099925
  • GC06M099987
  • GC06M097320

Summaries for USP45 Gene

Entrez Gene Summary for USP45 Gene

  • The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1. [provided by RefSeq, Sep 2016]

GeneCards Summary for USP45 Gene

USP45 (Ubiquitin Specific Peptidase 45) is a Protein Coding gene. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP16.

Additional gene information for USP45 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP45 Gene

Genomics for USP45 Gene

GeneHancer (GH) Regulatory Elements for USP45 Gene

Promoters and enhancers for USP45 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I099513 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.4 +6.3 6348 2.8 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 SP3 USP45 RPS3P5 LOC101927365 CCNC PNISR ENSG00000272017 TSTD3 PIR43976
GH06I099520 Promoter/Enhancer 1.5 Ensembl ENCODE 550.8 +0.0 32 2.7 HDGF SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 ZNF143 TSTD3 USP45 RPS3P5 LOC101927365
GH06I099566 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 42.2 -46.4 -46352 2.6 CLOCK MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ENSG00000272017 CCNC PNISR LOC101927365 USP45 RPS3P5 FBXL4 TSTD3 ENSG00000274603
GH06I098845 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 11.1 +675.9 675918 0.3 ZNF2 GLIS2 ZNF213 ARID2 ZNF143 DEK SP3 NCOA1 REST ZNF518A PNISR USP45 POU3F2 GC06M098840 FBXL4
GH06I099484 Enhancer 0.6 ENCODE 12 +36.5 36485 2.3 SMARCA5 PKNOX1 ZNF687 NR2F1 JUNB DPF2 NBN RUNX3 SPI1 RPS3P5 LOC101927365 TSTD3 USP45 PNISR PIR43976
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around USP45 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the USP45 gene promoter:

Genomic Locations for USP45 Gene

Genomic Locations for USP45 Gene
chr6:99,432,306-99,521,728
(GRCh38/hg38)
Size:
89,423 bases
Orientation:
Minus strand
chr6:99,880,182-99,969,604
(GRCh37/hg19)

Genomic View for USP45 Gene

Genes around USP45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP45 Gene

Proteins for USP45 Gene

  • Protein details for USP45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70EL2-UBP45_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 45
    Protein Accession:
    Q70EL2
    Secondary Accessions:
    • B2RXG0
    • Q5T062
    • Q86T44
    • Q86TC0
    • Q9BRU1

    Protein attributes for USP45 Gene

    Size:
    814 amino acids
    Molecular mass:
    91733 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI17192.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19761.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for USP45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP45 Gene

Selected DME Specific Peptides for USP45 Gene

Q70EL2:
  • QQQDSQELL
  • WLCLKCG
  • AYLLFYE
  • NLGNTCF

Post-translational modifications for USP45 Gene

Domains & Families for USP45 Gene

Gene Families for USP45 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q70EL2

UniProtKB/Swiss-Prot:

UBP45_HUMAN :
  • Belongs to the peptidase C19 family.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP45: view

Function for USP45 Gene

Molecular function for USP45 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme Numbers (IUBMB) for USP45 Gene

Phenotypes From GWAS Catalog for USP45 Gene

Gene Ontology (GO) - Molecular Function for USP45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity TAS --
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP45: view

Phenotypes for USP45 Gene

genes like me logo Genes that share phenotypes with USP45: view

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP45 Gene

Localization for USP45 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP45 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for USP45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 25538220
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 25538220
genes like me logo Genes that share ontologies with USP45: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for USP45 Gene

Pathways & Interactions for USP45 Gene

genes like me logo Genes that share pathways with USP45: view

Gene Ontology (GO) - Biological Process for USP45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IMP 25538220
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IEA,IMP 25538220
GO:0070911 global genome nucleotide-excision repair TAS --
genes like me logo Genes that share ontologies with USP45: view

No data available for SIGNOR curated interactions for USP45 Gene

Drugs & Compounds for USP45 Gene

No Compound Related Data Available

Transcripts for USP45 Gene

Unigene Clusters for USP45 Gene

Ubiquitin specific peptidase 45:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP45 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: - -
SP2: -
SP3:
SP4:
SP5: -

Relevant External Links for USP45 Gene

GeneLoc Exon Structure for
USP45
ECgene alternative splicing isoforms for
USP45

Expression for USP45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP45 Gene

Protein differential expression in normal tissues from HIPED for USP45 Gene

This gene is overexpressed in Seminal vesicle (10.4), Colon (9.7), Prostate (9.2), Urinary Bladder (8.7), Rectum (7.1), and Cardia (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for USP45 Gene



NURSA nuclear receptor signaling pathways regulating expression of USP45 Gene:

USP45

SOURCE GeneReport for Unigene cluster for USP45 Gene:

Hs.143410

mRNA Expression by UniProt/SwissProt for USP45 Gene:

Q70EL2-UBP45_HUMAN
Tissue specificity: Broadly expressed, with highest levels in ovary, skeletal muscle and spleen.

Evidence on tissue expression from TISSUES for USP45 Gene

  • Nervous system(4.3)
  • Bone marrow(4.2)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with USP45: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP45 Gene

Orthologs for USP45 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP45 33 34
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia USP45 33 34
  • 88.14 (n)
dog
(Canis familiaris)
Mammalia USP45 33 34
  • 83.62 (n)
rat
(Rattus norvegicus)
Mammalia Usp45 33
  • 83.53 (n)
mouse
(Mus musculus)
Mammalia Usp45 33 16 34
  • 81.52 (n)
oppossum
(Monodelphis domestica)
Mammalia USP45 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP45 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP45 34
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP45 34
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii usp45 33 34
  • 57.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4165 34
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyk-3 34
  • 14 (a)
OneToMany
Species where no ortholog for USP45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for USP45 Gene

ENSEMBL:
Gene Tree for USP45 (if available)
TreeFam:
Gene Tree for USP45 (if available)

Paralogs for USP45 Gene

Paralogs for USP45 Gene

genes like me logo Genes that share paralogs with USP45: view

Variants for USP45 Gene

Sequence variations from dbSNP and Humsavar for USP45 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000008548 -- 99,461,044(-) G/A 3_prime_UTR_variant, intron_variant
rs1000080320 -- 99,460,682(-) T/C 3_prime_UTR_variant, intron_variant
rs1000083214 -- 99,450,280(-) CC/C genic_downstream_transcript_variant, intron_variant
rs1000129452 -- 99,432,458(-) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000160564 -- 99,432,102(-) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for USP45 Gene

Variant ID Type Subtype PubMed ID
esv3610119 CNV loss 21293372
esv3610120 CNV loss 21293372
nsv1029536 CNV loss 25217958
nsv463983 CNV loss 19166990
nsv604254 CNV loss 21841781

Variation tolerance for USP45 Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.05; 96.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for USP45 Gene

Human Gene Mutation Database (HGMD)
USP45
SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP45 Gene

Disorders for USP45 Gene

Additional Disease Information for USP45

No disorders were found for USP45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP45 Gene

Publications for USP45 Gene

  1. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V … López-Otín C (Biochemical and biophysical research communications 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses. (PMID: 25538220) Perez-Oliva AB … Alessi DR (The EMBO journal 2015) 3 58

Products for USP45 Gene

  • Addgene plasmids for USP45

Sources for USP45 Gene

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