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USP45 Gene

protein-coding   GIFtS: 50
GCID: GC06M099925

Ubiquitin Specific Peptidase 45

(Previous name: ubiquitin specific protease 45)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 451 2     Ubiquitin Carboxyl-Terminal Hydrolase 452
Ubiquitin Specific Protease 451 2     Ubiquitin Thiolesterase 452
Deubiquitinating Enzyme 452 3     EC 3.4.19.123
Ubiquitin Thioesterase 452 3     EC 3.1.2.158
Ubiquitin-Specific-Processing Protease 452 3     

External Ids:    HGNC: 200801   Entrez Gene: 850152   Ensembl: ENSG000001235527   UniProtKB: Q70EL23   

Export aliases for USP45 gene to outside databases

Previous GC identifers: GC06M099880 GC06M099987 GC06M097320


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for USP45 Gene:
USP45 (ubiquitin specific peptidase 45) is a protein-coding gene. Diseases associated with USP45 include malaria. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP19.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP45 gene promoter:
         ATF-2   CUTL1   POU2F1   POU2F1b   POU2F1a   FOXO1a   c-Jun   POU2F1c   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for USP45

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP45


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16.2   Ensembl cytogenetic band:  6q16.2   HGNC cytogenetic band: 6q16.2

USP45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP45 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M099925:  view genomic region     (about GC identifiers)

Start:
99,880,182 bp from pter      End:
99,969,604 bp from pter
Size:
89,423 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UBP45_HUMAN, Q70EL2 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 45  
Size: 814 amino acids; 91733 Da
Sequence caution: Sequence=CAI17192.1; Type=Erroneous gene model prediction; Sequence=CAI19761.1; Type=Erroneous
gene model prediction;
Secondary accessions: B2RXG0 Q5T062 Q86T44 Q86TC0 Q9BRU1
Alternative splicing: 3 isoforms:  Q70EL2-1   Q70EL2-2   Q70EL2-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP45: NX_Q70EL2

Explore proteomics data for USP45 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys391
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for USP45 (Q70EL2)
     NLGNTCF  WLCLKCG  AYLLFYE  QQQDSQELL 


    See USP45 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073950.1  
    ENSEMBL proteins: 
     ENSP00000424372   ENSP00000421248   ENSP00000333376   ENSP00000358236   ENSP00000422460  
     ENSP00000423374   ENSP00000421706   ENSP00000425876   ENSP00000330540   ENSP00000423993  
     ENSP00000426861   ENSP00000376495   ENSP00000439569   ENSP00000358234  

    USP45 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for USP45
    OriGene Custom MassSpec
    OriGene Custom Protein Services for USP45
    GenScript Custom Purified and Recombinant Proteins Services for USP45
    Novus Biologicals USP45 Proteins
    Novus Biologicals USP45 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP45

    USP45 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for USP45
    OriGene Custom Antibody Services for USP45
    Novus Biologicals USP45 Antibodies
    Abcam antibodies for USP45
    Cloud-Clone Corp. Antibodies for USP45
    Search ThermoFisher Antibodies for USP45
    LSBio Antibodies in human, mouse, rat for USP45

    USP45 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP45
    Cloud-Clone Corp. CLIAs for USP45


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    5 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR013083 Znf_RING/FYVE/PHD
     IPR028889 UCH/PAN2
     IPR001607 Znf_UBP

    Graphical View of Domain Structure for InterPro Entry Q70EL2

    ProtoNet protein and cluster: Q70EL2

    2 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB001607 Zn-finger in ubiquitin thiolesterase


    UniProtKB/Swiss-Prot: UBP45_HUMAN, Q70EL2
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 UBP-type zinc finger
    Similarity: Contains 1 USP domain


    USP45 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP45_HUMAN, Q70EL2
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity ----
    GO:0004843ubiquitin-specific protease activity IDA14715245
    GO:0008234cysteine-type peptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    USP45 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for USP45:
     Increased S DNA content 

         1 MGI phenotypic allele for Usp45 (no phenotypes)

    USP45 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP45
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP45

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP45
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP45

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP45:
    hsa-mir-32-5p (MIRT028362), hsa-mir-192-5p (MIRT026646), hsa-let-7f-5p (MIRT051365)

    Block miRNA regulation of human, mouse, rat USP45 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP45 (see all 42):
    hsa-miR-513a-5p hsa-miR-25 hsa-miR-30d hsa-miR-218 hsa-miR-30a hsa-miR-124 hsa-miR-298 hsa-miR-155*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP45
    Predesigned siRNA for gene silencing in human, mouse, rat USP45

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP45

    Clone
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    OriGene clones in human, mouse for USP45 (see all 7)
    OriGene ORF clones in mouse, rat for USP45
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP45 (NM_001080481)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP45
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP45

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for USP45
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP45 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP45


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP45
    Interactions:

        Search GeneGlobe Interaction Network for USP45

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP45 (Q70EL23 ENSP000003333764) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FARS2O953633, ENSP000002746804I2D: score=2 STRING: ENSP00000274680
    GLTSCR2Q9NZM53, ENSP000002468024I2D: score=2 STRING: ENSP00000246802
    MYH10P355803, ENSP000002692434I2D: score=2 STRING: ENSP00000269243
    MYL12BO149503, ENSP000002375004I2D: score=2 STRING: ENSP00000237500
    MYL6P606603, ENSP000002934224I2D: score=2 STRING: ENSP00000293422
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016579protein deubiquitination IDA14715245

    USP45 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP45 (UBP45)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for USP45 gene (2 alternative transcripts): 
    NM_001080481.1  NM_032929.1  

    Unigene Cluster for USP45:

    Ubiquitin specific peptidase 45
    Hs.143410  [show with all ESTs]
    Unigene Representative Sequence: NM_001080481
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000500704(uc010kcq.2) ENST00000496518 ENST00000327681(uc003ppx.2)
    ENST00000369233 ENST00000513344 ENST00000506871 ENST00000511403 ENST00000496090
    ENST00000507717 ENST00000329966(uc003pqa.3) ENST00000472914 ENST00000369232
    ENST00000508908 ENST00000392738(uc003ppv.2 uc003ppw.2) ENST00000539675
    ENST00000369231
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP45 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP45 (see all 42):
    hsa-miR-513a-5p hsa-miR-25 hsa-miR-30d hsa-miR-218 hsa-miR-30a hsa-miR-124 hsa-miR-298 hsa-miR-155*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for USP45
    Predesigned siRNA for gene silencing in human, mouse, rat USP45
    Clone
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    OriGene clones in human, mouse for USP45 (see all 7)
    OriGene ORF clones in mouse, rat for USP45
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP45 (NM_001080481)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP45
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP45
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for USP45
    OriGene qSTAR qPCR primer pairs in human, mouse for USP45
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP45
      QuantiTect SYBR Green Assays in human, mouse, rat USP45
      QuantiFast Probe-based Assays in human, mouse, rat USP45

    Additional mRNA sequence: 

    AJ583819.2 AK123299.1 AK310643.1 AL713747.2 AL832030.1 AL832037.1 AL832040.1 BC005991.1 
    BC150648.2 BC157838.1 

    14 DOTS entries:

    DT.106573  DT.70104415  DT.101961562  DT.121315964  DT.95155699  DT.100035499  DT.91666297  DT.40188681 
    DT.75110673  DT.100012475  DT.121315875  DT.91700542  DT.91860400  DT.121316063 

    Selected AceView cDNA sequences (see all 71):

    CR625622 CR614890 CD655289 CR608058 BU618757 BU631216 CR593749 BQ775514 
    CA427289 AA334141 AJ583819 AW965414 BC005991 AW130352 CA427715 AL713747 
    BE219815 AK123299 CD642341 AI273795 BU631204 AI434081 AL559960 BX481777 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for USP45    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
    SP1:                                                        -                 -                                                         
    SP2:        -                                                                                                                           
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                                                                    -               


    ECgene alternative splicing isoforms for USP45

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP45 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATAATAAAT
    USP45 Expression
    About this image

    USP45 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP45 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.143410

    UniProtKB/Swiss-Prot: UBP45_HUMAN, Q70EL2
    Tissue specificity: Broadly expressed, with highest levels in ovary, skeletal muscle and spleen

        Custom PCR Arrays for USP45
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    QuantiFast Probe-based Assays in human, mouse, rat USP45
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP45

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for USP45 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp451 , 5 ubiquitin specific petidase 451, 5 81.52(n)1
    78.59(a)1
      4 (8.93 cM)5
    775931  NM_152825.21  NP_690038.11 
     217671565 
    chicken
    (Gallus gallus)
    Aves USP456
    Gallus gallus ubiquitin specific peptidase 45 (USP...
    68(a)
    1 ↔ 1
    3(70842602-70898825)
    lizard
    (Anolis carolinensis)
    Reptilia USP456
    ubiquitin specific peptidase 45
    62(a)
    1 ↔ 1
    1(171734280-171806846)
    zebrafish
    (Danio rerio)
    Actinopterygii usp451 ubiquitin specific peptidase 45 57.55(n)
    55.19(a)
      564004  XM_687364.4  XP_692456.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG41656
    --
    23(a)
    1 → many
    X(5315563-5320941)
    worm
    (Caenorhabditis elegans)
    Secernentea cyk-36
    Protein CYK-3, isoform b (cyk-3) mRNA, complete cd...
    14(a)
    1 → many
    III(6020165-6024653) WBGene00000874


    ENSEMBL Gene Tree for USP45 (if available)
    TreeFam Gene Tree for USP45 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP45 gene
    USP192  USP62  USP152  USP112  USP162  USP312  USP432  USP322  
    USP42  
    4 SIMAP similar genes for USP45 using alignment to 11 protein entries:     UBP45_HUMAN (see all proteins):
    DKFZp313B2010    USP16    USP30    USP2

    USP45 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP45 (see all 1666)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1453846271,2
    C--99879685(+) AGACAC/TAAATG 1 -- ds50010--------
    rs1487976931,2
    --99879718(+) TGCTGA/GTGCAA 1 -- ds50010--------
    rs1422709261,2
    --99879922(+) GTTTAC/TGTCCC 1 -- ds50010--------
    rs1512585371,2
    --99879934(+) TACAAC/TATTCA 1 -- ds50010--------
    rs1416273891,2
    --99879969(+) GGAGAC/TAGGGC 1 -- ds50010--------
    rs126051,2
    C,F--99880131(-) GCCAGT/CAGACT 1 -- ds500112Minor allele frequency- C:0.37MN NA WA CSA EA 744
    rs1470549661,2
    --99880159(+) CCCAGA/CTCCCA 1 -- ds50010--------
    rs1928289921,2
    --99880274(+) CATTCC/TGTCAA 1 -- ut310--------
    rs1378633401,2
    C--99880290(+) TAAAC-/TGTGAAA 1 -- ut310--------
    rs785489691,2
    C,F--99880344(+) TATTAT/CGCATG 1 -- ut311Minor allele frequency- C:0.11WA 118

    HapMap Linkage Disequilibrium report for USP45 (99880182 - 99969604 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for USP45:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv886440CNV Loss21882294
    nsv886439CNV Loss21882294
    nsv463983CNV Loss19166990
    nsv886438CNV Gain21882294
    nsv886436CNV Gain21882294

    Human Gene Mutation Database (HGMD): USP45
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP45
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for USP45:    
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    malaria


    USP45 for disorders           About GeneDecksing

    Genetic Association Database (GAD): USP45

    Export disorders for USP45 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP45 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with USP45)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    4. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (Science 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85015 HGNC: 20080 AceView: USP45 Ensembl:ENSG00000123552 euGenes: HUgn85015
    ECgene: USP45 H-InvDB: USP45

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for USP45 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP45 gene:
    Search GeneIP for patents involving USP45

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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