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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP45 Gene

protein-coding   GIFtS: 47
GCID: GC06M099925

Ubiquitin Specific Peptidase 45

(Previous name: ubiquitin specific protease 45)
  Search for USP45
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 451 2     Ubiquitin Carboxyl-Terminal Hydrolase 452
Ubiquitin Specific Protease 451 2     Ubiquitin Thiolesterase 452
Deubiquitinating Enzyme 452 3     EC 3.4.19.123
Ubiquitin Thioesterase 452 3     EC 3.1.2.158
Ubiquitin-Specific-Processing Protease 452 3     

External Ids:    HGNC: 200801   Entrez Gene: 850152   Ensembl: ENSG000001235527   UniProtKB: Q70EL23   

Export aliases for USP45 gene to outside databases

Previous GC identifers: GC06M099880 GC06M099987 GC06M097320


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for USP45 Gene: 
USP45 (ubiquitin specific peptidase 45) is a protein-coding gene. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP19.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP45 gene promoter:
         ATF-2   CUTL1   POU2F1   POU2F1b   POU2F1a   FOXO1a   c-Jun   POU2F1c   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for USP45

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP45


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16.2   Ensembl cytogenetic band:  6q16.2   HGNC cytogenetic band: 6q16.2

USP45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP45 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M099925:  view genomic region     (about GC identifiers)

Start:
99,880,182 bp from pter      End:
99,969,604 bp from pter
Size:
89,423 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP45_HUMAN, Q70EL2 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 45  
Size: 814 amino acids; 91733 Da
Sequence caution: Sequence=CAI17192.1; Type=Erroneous gene model prediction; Sequence=CAI19761.1; Type=Erroneous
gene model prediction;
Secondary accessions: B2RXG0 Q5T062 Q86T44 Q86TC0 Q9BRU1
Alternative splicing: 3 isoforms:  Q70EL2-1   Q70EL2-2   Q70EL2-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP45: NX_Q70EL2

Explore proteomics data for USP45 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q70EL2

  • 4 DME Specific Peptides for USP45 (Q70EL2)
     NLGNTCF  WLCLKCG  AYLLFYE  QQQDSQELL 

    USP45 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP45 Protein Expression
    REFSEQ proteins: NP_001073950.1  
    ENSEMBL proteins: 
     ENSP00000424372   ENSP00000421248   ENSP00000333376   ENSP00000358236   ENSP00000422460  
     ENSP00000423374   ENSP00000421706   ENSP00000425876   ENSP00000330540   ENSP00000423993  
     ENSP00000426861   ENSP00000376495   ENSP00000439569   ENSP00000358234  

    Human Recombinant Protein Products for USP45: 
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    OriGene Protein Over-expression Lysate for USP45
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for USP45
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    Novus Biologicals USP45 Proteins
    Novus Biologicals USP45 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP45 


    USP45 Antibody Products: 
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    Abcam antibodies for USP45
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    LSBio Antibodies in human, mouse, rat for USP45 

    Assay Products for USP45: 
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    Cloud-Clone Corp. ELISAs for USP45 
    Cloud-Clone Corp. CLIAs for USP45


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    4 InterPro protein domains:
     IPR001394 Peptidase_C19
     IPR001607 Znf_UBP
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q70EL2

    ProtoNet protein and cluster: Q70EL2

    2 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB001607 Zn-finger in ubiquitin thiolesterase


    UniProtKB/Swiss-Prot: UBP45_HUMAN, Q70EL2
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 UBP-type zinc finger


    USP45 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP45_HUMAN, Q70EL2
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IEA--
    GO:0008234cysteine-type peptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    USP45 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for USP45:
     Increased S DNA content 

         1 MGI phenotypic allele for Usp45 (no phenotypes)

    USP45 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for USP45 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP45

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP45 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP45 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP45
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate USP45 (see all 42):
    hsa-miR-513a-5p hsa-miR-25 hsa-miR-30d hsa-miR-218 hsa-miR-30a hsa-miR-124 hsa-miR-298 hsa-miR-155*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of USP45

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for USP45
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP45 (NM_001080481)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP45
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP45
    Sirion Biotech Customized lentivirus for stable overexpression of USP45 
                         Customized lentivirus expression plasmids for stable overexpression of USP45 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP45


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP45

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for USP45 (Q70EL23 ENSP000003333764) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FARS2O953633, ENSP000002746804I2D: score=2 STRING: ENSP00000274680
    GLTSCR2Q9NZM53, ENSP000002468024I2D: score=2 STRING: ENSP00000246802
    MYH10P355803, ENSP000002692434I2D: score=2 STRING: ENSP00000269243
    MYL12BO149503, ENSP000002375004I2D: score=2 STRING: ENSP00000237500
    MYL6P606603, ENSP000002934224I2D: score=2 STRING: ENSP00000293422
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--

    USP45 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP45 (UBP45)

    Search CenterWatch for drugs/clinical trials and news about USP45 / UBP45

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP45 gene (2 alternative transcripts): 
    NM_001080481.1  NM_032929.1  

    Unigene Cluster for USP45:

    Ubiquitin specific peptidase 45
    Hs.143410  [show with all ESTs]
    Unigene Representative Sequence: NM_001080481
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000500704(uc010kcq.2) ENST00000496518 ENST00000327681(uc003ppx.2)
    ENST00000369233 ENST00000513344 ENST00000506871 ENST00000511403 ENST00000496090
    ENST00000507717 ENST00000329966(uc003pqa.3) ENST00000472914 ENST00000369232
    ENST00000508908 ENST00000392738(uc003ppv.2 uc003ppw.2) ENST00000539675
    ENST00000369231
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP45
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate USP45 (see all 42):
    hsa-miR-513a-5p hsa-miR-25 hsa-miR-30d hsa-miR-218 hsa-miR-30a hsa-miR-124 hsa-miR-298 hsa-miR-155*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP45
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP45
    Clone
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    OriGene clones in human, mouse for USP45 (see all 8)
    OriGene ORF clones in mouse, rat for USP45
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP45 (NM_001080481)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP45
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP45
    Sirion Biotech Customized lentivirus for stable overexpression of USP45 
                         Customized lentivirus expression plasmids for stable overexpression of USP45 
    Primer
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    OriGene qPCR primer pairs and template standards for USP45
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP45
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP45
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP45

    Additional mRNA sequence: 

    AJ583819.2 AK123299.1 AK310643.1 AL713747.2 AL832030.1 AL832037.1 AL832040.1 BC005991.1 
    BC150648.2 BC157838.1 

    14 DOTS entries:

    DT.106573  DT.70104415  DT.101961562  DT.121315964  DT.95155699  DT.100035499  DT.91666297  DT.40188681 
    DT.75110673  DT.100012475  DT.121315875  DT.91700542  DT.91860400  DT.121316063 

    24/71 AceView cDNA sequences (see all 71):

    BU618757 CR625622 CR593749 CR608058 AA334141 CR614890 CD655289 AJ583819 
    CA427289 BQ775514 BU631216 AL713747 AA443848 CD642341 BG494084 BG617247 
    AK123299 BC005991 BX481777 AW965414 BU631204 BQ229687 CA427715 BI964090 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for USP45    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
    SP1:                                                        -                 -                                                         
    SP2:        -                                                                                                                           
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                                                                    -               


    ECgene alternative splicing isoforms for USP45

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP45 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATAATAAAT
    USP45 Expression
    About this image


    See USP45 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP45

    SOURCE GeneReport for Unigene cluster: Hs.143410

    UniProtKB/Swiss-Prot: UBP45_HUMAN, Q70EL2
    Tissue specificity: Broadly expressed, with highest levels in ovary, skeletal muscle and spleen

        SABiosciences Custom PCR Arrays for USP45
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP45

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USP45 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp451 , 5 ubiquitin specific petidase 451, 5 81.52(n)1
    78.59(a)1
      4 (8.93 cM)5
    775931  NM_152825.21  NP_690038.11 
     217671565 
    chicken
    (Gallus gallus)
    Aves USP456
    ubiquitin specific peptidase 45
    68(a)
    1 ↔ 1
    3(70842602-70898825)
    lizard
    (Anolis carolinensis)
    Reptilia USP456
    Ubiquitin carboxyl-terminal hydrolase
    62(a)
    1 ↔ 1
    1(171734280-171806846)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5640041 ubiquitin carboxyl-terminal hydrolase 45-like 58.95(n)
    55.98(a)
      564004  XM_687364.3  XP_692456.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG41651 CG4165 46.08(n)
    38.91(a)
      31458  NM_131992.2  NP_572220.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP86
    Ubiquitin-specific protease that is a component of...
    25(a)
    1 → many
    XIII(716715-718130)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBP21 ubiquitin carboxyl-terminal hydrolase 2 47.45(n)
    37.07(a)
      839397  NM_100364.3  NP_563719.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g05051001 hypothetical protein 45.37(n)
    34.38(a)
      4347503  NM_001070134.1  NP_001063599.1 


    ENSEMBL Gene Tree for USP45 (if available)
    TreeFam Gene Tree for USP45 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP45 gene
    USP192  USP62  USP152  USP112  USP162  USP312  USP432  USP322  
    USP42  
    3 SIMAP similar genes for USP45 using alignment to 11 protein entries:     UBP45_HUMAN (see all proteins):
    DKFZp313B2010    USP16    USP2

    USP45 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1666 SNPs in USP45 are shown (see all 1666)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1453846271,2
    C--99879685(+) AGACAC/TAAATG 1 -- ds50010--------
    rs1487976931,2
    --99879718(+) TGCTGA/GTGCAA 1 -- ds50010--------
    rs1422709261,2
    --99879922(+) GTTTAC/TGTCCC 1 -- ds50010--------
    rs1512585371,2
    --99879934(+) TACAAC/TATTCA 1 -- ds50010--------
    rs1416273891,2
    --99879969(+) GGAGAC/TAGGGC 1 -- ds50010--------
    rs126051,2
    C,F--99880131(-) GCCAGT/CAGACT 1 -- ds500112Minor allele frequency- C:0.37MN NA WA CSA EA 744
    rs1470549661,2
    --99880159(+) CCCAGA/CTCCCA 1 -- ds50010--------
    rs1928289921,2
    --99880274(+) CATTCC/TGTCAA 1 -- ut310--------
    rs1378633401,2
    C--99880290(+) TAAAC-/TGTGAAA 1 -- ut310--------
    rs785489691,2
    C,F--99880344(+) TATTAT/CGCATG 1 -- ut311Minor allele frequency- C:0.11WA 118

    HapMap Linkage Disequilibrium report for USP45 (99880182 - 99969604 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for USP45:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv886440CNV Loss21882294
    nsv886439CNV Loss21882294
    nsv463983CNV Loss19166990
    nsv886438CNV Gain21882294
    nsv886436CNV Gain21882294


    Human Gene Mutation Database (HGMD): USP45
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    USP45 for disorders           About MalaCards

    USP45 for disorders           About GeneDecksing

    Genetic Association Database (GAD): USP45

    Export disorders for USP45 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP45 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with USP45)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 85015 HGNC: 20080 AceView: USP45 Ensembl:ENSG00000123552 euGenes: HUgn85015
    ECgene: USP45 H-InvDB: USP45

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP45 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP45 gene:
    Search GeneIP for patents involving USP45

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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