Free for academic non-profit institutions. Other users need a Commercial license

Aliases for USP45 Gene

Aliases for USP45 Gene

  • Ubiquitin Specific Peptidase 45 2 3
  • Ubiquitin-Specific-Processing Protease 45 4
  • Ubiquitin Specific Protease 45 2
  • Deubiquitinating Enzyme 45 4
  • Ubiquitin Thioesterase 45 4
  • EC 4
  • EC 63

External Ids for USP45 Gene

Previous GeneCards Identifiers for USP45 Gene

  • GC06M099880
  • GC06M099925
  • GC06M099987
  • GC06M097320

Summaries for USP45 Gene

GeneCards Summary for USP45 Gene

USP45 (Ubiquitin Specific Peptidase 45) is a Protein Coding gene. GO annotations related to this gene include ubiquitin thiolesterase activity and cysteine-type peptidase activity. An important paralog of this gene is USP4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP45 Gene

Genomics for USP45 Gene

Regulatory Elements for USP45 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for USP45 Gene

99,432,306 bp from pter
99,521,728 bp from pter
89,423 bases
Minus strand

Genomic View for USP45 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP45 Gene

Proteins for USP45 Gene

  • Protein details for USP45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 45
    Protein Accession:
    Secondary Accessions:
    • B2RXG0
    • Q5T062
    • Q86T44
    • Q86TC0
    • Q9BRU1

    Protein attributes for USP45 Gene

    814 amino acids
    Molecular mass:
    91733 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI17192.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19761.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for USP45 Gene


neXtProt entry for USP45 Gene

Proteomics data for USP45 Gene at MOPED

Selected DME Specific Peptides for USP45 Gene

Post-translational modifications for USP45 Gene

  • Ubiquitination at Lys391
  • Modification sites at PhosphoSitePlus

Domains for USP45 Gene

Gene Families for USP45 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 UBP-type zinc finger.
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 UBP-type zinc finger.
genes like me logo Genes that share domains with USP45: view

Function for USP45 Gene

Molecular function for USP45 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme Numbers (IUBMB) for USP45 Gene

Gene Ontology (GO) - Molecular Function for USP45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0004843 ubiquitin-specific protease activity IDA 14715245
GO:0008234 cysteine-type peptidase activity --
GO:0008270 zinc ion binding IEA --
GO:0036459 ubiquitinyl hydrolase activity --
genes like me logo Genes that share ontologies with USP45: view

Phenotypes for USP45 Gene

GenomeRNAi human phenotypes for USP45:
genes like me logo Genes that share phenotypes with USP45: view

Animal Model Products

miRNA for USP45 Gene

miRTarBase miRNAs that target USP45

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP45

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for USP45 Gene

Localization for USP45 Gene

Subcellular locations from

Jensen Localization Image for USP45 Gene COMPARTMENTS Subcellular localization image for USP45 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP45 Gene

Pathways for USP45 Gene

SuperPathways for USP45 Gene

No Data Available

Gene Ontology (GO) - Biological Process for USP45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0016579 protein deubiquitination IDA 14715245
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0061136 regulation of proteasomal protein catabolic process IBA --
genes like me logo Genes that share ontologies with USP45: view

No data available for Pathways by source for USP45 Gene

Transcripts for USP45 Gene

Unigene Clusters for USP45 Gene

Ubiquitin specific peptidase 45:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP45

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP45 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: - -
SP2: -
SP5: -

Relevant External Links for USP45 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP45 Gene

mRNA expression in normal human tissues for USP45 Gene

Protein differential expression in normal tissues for USP45 Gene

This gene is overexpressed in Seminal vesicle (10.4), Colon (9.7), Prostate (9.2), Urinary Bladder (8.7), Rectum (7.1), and Cardia (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for USP45 Gene

SOURCE GeneReport for Unigene cluster for USP45 Gene Hs.143410

mRNA Expression by UniProt/SwissProt for USP45 Gene

Tissue specificity: Broadly expressed, with highest levels in ovary, skeletal muscle and spleen.
genes like me logo Genes that share expressions with USP45: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Expression partners for USP45 Gene

Orthologs for USP45 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP45 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia USP45 35
  • 88.14 (n)
  • 82.27 (a)
USP45 36
  • 81 (a)
(Canis familiaris)
Mammalia USP45 35
  • 83.62 (n)
  • 77.37 (a)
USP45 36
  • 74 (a)
(Mus musculus)
Mammalia Usp45 35
  • 81.52 (n)
  • 78.59 (a)
Usp45 16
Usp45 36
  • 78 (a)
(Pan troglodytes)
Mammalia USP45 35
  • 99.51 (n)
  • 99.02 (a)
USP45 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Usp45 35
  • 83.53 (n)
  • 82.8 (a)
(Monodelphis domestica)
Mammalia USP45 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia USP45 36
  • 66 (a)
(Gallus gallus)
Aves USP45 36
  • 68 (a)
(Anolis carolinensis)
Reptilia USP45 36
  • 62 (a)
(Danio rerio)
Actinopterygii usp45 35
  • 57.55 (n)
  • 55.19 (a)
usp45 36
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4165 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea cyk-3 36
  • 14 (a)
Species with no ortholog for USP45:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for USP45 Gene

Gene Tree for USP45 (if available)
Gene Tree for USP45 (if available)

Paralogs for USP45 Gene

Paralogs for USP45 Gene

genes like me logo Genes that share paralogs with USP45: view

Variants for USP45 Gene

Sequence variations from dbSNP and Humsavar for USP45 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs12605 -- 99,432,255(-) GCCAG(C/T)AGACT downstream-variant-500B
rs733615 -- 99,497,918(+) ttttg(A/C)ccaga intron-variant
rs912338 -- 99,498,009(+) gttag(A/G)tacta intron-variant
rs994197 -- 99,512,818(+) CAAAC(C/T)TCCTC intron-variant
rs994198 -- 99,512,885(+) TCTGA(C/T)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP45 Gene

Variant ID Type Subtype PubMed ID
nsv886436 CNV Gain 21882294
nsv886438 CNV Gain 21882294
nsv886439 CNV Loss 21882294
nsv886440 CNV Loss 21882294
nsv463983 CNV Loss 19166990

Relevant External Links for USP45 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP45 Gene

Disorders for USP45 Gene

Relevant External Links for USP45

Genetic Association Database (GAD)

No disorders were found for USP45 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for USP45 Gene

Publications for USP45 Gene

  1. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for USP45 Gene

Sources for USP45 Gene

Back to Top