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Aliases for USP45 Gene

Aliases for USP45 Gene

  • Ubiquitin Specific Peptidase 45 2 3 5
  • Ubiquitin-Specific-Processing Protease 45 4
  • Ubiquitin Specific Protease 45 2
  • Deubiquitinating Enzyme 45 4
  • Ubiquitin Thioesterase 45 4
  • EC 3.4.19.12 4
  • EC 3.1.2.15 63

External Ids for USP45 Gene

Previous GeneCards Identifiers for USP45 Gene

  • GC06M099880
  • GC06M099925
  • GC06M099987
  • GC06M097320

Summaries for USP45 Gene

GeneCards Summary for USP45 Gene

USP45 (Ubiquitin Specific Peptidase 45) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER). GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP49.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP45 Gene

Genomics for USP45 Gene

Regulatory Elements for USP45 Gene

Promoters for USP45 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around USP45 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP45 Gene

Chromosome:
6
Start:
99,432,306 bp from pter
End:
99,521,728 bp from pter
Size:
89,423 bases
Orientation:
Minus strand

Genomic View for USP45 Gene

Genes around USP45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP45 Gene

Proteins for USP45 Gene

  • Protein details for USP45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70EL2-UBP45_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 45
    Protein Accession:
    Q70EL2
    Secondary Accessions:
    • B2RXG0
    • Q5T062
    • Q86T44
    • Q86TC0
    • Q9BRU1

    Protein attributes for USP45 Gene

    Size:
    814 amino acids
    Molecular mass:
    91733 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI17192.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19761.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for USP45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP45 Gene

Proteomics data for USP45 Gene at MOPED

Selected DME Specific Peptides for USP45 Gene

Post-translational modifications for USP45 Gene

  • Ubiquitination at Lys 391
  • Modification sites at PhosphoSitePlus

Domains & Families for USP45 Gene

Gene Families for USP45 Gene

Graphical View of Domain Structure for InterPro Entry

Q70EL2

UniProtKB/Swiss-Prot:

UBP45_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 UBP-type zinc finger.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
Similarity:
  • Contains 1 UBP-type zinc finger.
genes like me logo Genes that share domains with USP45: view

Function for USP45 Gene

Molecular function for USP45 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme Numbers (IUBMB) for USP45 Gene

Gene Ontology (GO) - Molecular Function for USP45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity TAS --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP45: view

Phenotypes for USP45 Gene

genes like me logo Genes that share phenotypes with USP45: view

Animal Model Products

  • Taconic Biosciences Mouse Models for USP45

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP45 Gene

Localization for USP45 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP45 Gene COMPARTMENTS Subcellular localization image for USP45 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP45 Gene

Pathways & Interactions for USP45 Gene

genes like me logo Genes that share pathways with USP45: view

Gene Ontology (GO) - Biological Process for USP45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IEA,IMP 25538220
genes like me logo Genes that share ontologies with USP45: view

No data available for SIGNOR curated interactions for USP45 Gene

Drugs & Compounds for USP45 Gene

No Compound Related Data Available

Transcripts for USP45 Gene

Unigene Clusters for USP45 Gene

Ubiquitin specific peptidase 45:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP45 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: - -
SP2: -
SP3:
SP4:
SP5: -

Relevant External Links for USP45 Gene

GeneLoc Exon Structure for
USP45
ECgene alternative splicing isoforms for
USP45

Expression for USP45 Gene

mRNA expression in normal human tissues for USP45 Gene

Protein differential expression in normal tissues from HIPED for USP45 Gene

This gene is overexpressed in Seminal vesicle (10.4), Colon (9.7), Prostate (9.2), Urinary Bladder (8.7), Rectum (7.1), and Cardia (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for USP45 Gene



SOURCE GeneReport for Unigene cluster for USP45 Gene Hs.143410

mRNA Expression by UniProt/SwissProt for USP45 Gene

Q70EL2-UBP45_HUMAN
Tissue specificity: Broadly expressed, with highest levels in ovary, skeletal muscle and spleen.
genes like me logo Genes that share expression patterns with USP45: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for USP45 Gene

Orthologs for USP45 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP45 36
  • 99 (a)
OneToOne
USP45 35
  • 99.51 (n)
  • 99.02 (a)
cow
(Bos Taurus)
Mammalia USP45 35
  • 88.14 (n)
  • 82.27 (a)
USP45 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP45 36
  • 74 (a)
OneToOne
USP45 35
  • 83.62 (n)
  • 77.37 (a)
mouse
(Mus musculus)
Mammalia Usp45 16
Usp45 35
  • 81.52 (n)
  • 78.59 (a)
Usp45 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia USP45 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP45 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp45 35
  • 83.53 (n)
  • 82.8 (a)
chicken
(Gallus gallus)
Aves USP45 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP45 36
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii usp45 36
  • 50 (a)
OneToOne
usp45 35
  • 57.55 (n)
  • 55.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4165 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyk-3 36
  • 14 (a)
OneToMany
Species with no ortholog for USP45:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for USP45 Gene

ENSEMBL:
Gene Tree for USP45 (if available)
TreeFam:
Gene Tree for USP45 (if available)

Paralogs for USP45 Gene

Paralogs for USP45 Gene

genes like me logo Genes that share paralogs with USP45: view

Variants for USP45 Gene

Sequence variations from dbSNP and Humsavar for USP45 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs7744845 - 99,508,684(+) TTCTT(C/T)TAAAC reference, missense
rs6570065 - 99,435,828(+) ATTCA(C/G/T)TATCA reference, missense, utr-variant-3-prime
rs41288947 - 99,446,210(+) TGGAT(C/G)TGAAC intron-variant, reference, missense
rs733615 -- 99,497,918(+) ttttg(A/C)ccaga intron-variant
rs912338 -- 99,498,009(+) gttag(A/G)tacta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP45 Gene

Variant ID Type Subtype PubMed ID
nsv886436 CNV Gain 21882294
nsv886438 CNV Gain 21882294
nsv886439 CNV Loss 21882294
nsv886440 CNV Loss 21882294
nsv463983 CNV Loss 19166990

Variation tolerance for USP45 Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.05; 96.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP45 Gene

HapMap Linkage Disequilibrium report
USP45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP45 Gene

Disorders for USP45 Gene

Relevant External Links for USP45

Genetic Association Database (GAD)
USP45
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP45

No disorders were found for USP45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP45 Gene

Publications for USP45 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  3. USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses. (PMID: 25538220) Perez-Oliva A.B. … Alessi D.R. (EMBO J. 2015) 3
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  5. High-throughput mapping of a dynamic signaling network in mammalian cells. (PMID: 15761153) Barrios-Rodiles M. … Wrana J.L. (Science 2005) 3

Products for USP45 Gene

Sources for USP45 Gene

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