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Aliases for USP44 Gene

Aliases for USP44 Gene

  • Ubiquitin Specific Peptidase 44 2 3
  • Ubiquitin-Specific-Processing Protease 44 4
  • Ubiquitin Specific Protease 44 2
  • Deubiquitinating Enzyme 44 4
  • Ubiquitin Thioesterase 44 4
  • EC 3.4.19.12 4
  • EC 3.1.2.15 64

External Ids for USP44 Gene

Summaries for USP44 Gene

Entrez Gene Summary for USP44 Gene

  • Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP44 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]

GeneCards Summary for USP44 Gene

USP44 (Ubiquitin Specific Peptidase 44) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include ubiquitin thiolesterase activity and ubiquitin-specific protease activity. An important paralog of this gene is USP49.

UniProtKB/Swiss-Prot for USP44 Gene

  • Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.

Gene Wiki entry for USP44 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP44 Gene

Genomics for USP44 Gene

Genomic Location for USP44 Gene

Start:
95,516,560 bp from pter
End:
95,551,490 bp from pter
Size:
34,931 bases
Orientation:
Minus strand

Genomic View for USP44 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP44 Gene

Regulatory Elements for USP44 Gene

Proteins for USP44 Gene

  • Protein details for USP44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0E7-UBP44_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 44
    Protein Accession:
    Q9H0E7
    Secondary Accessions:
    • B2RDW3

    Protein attributes for USP44 Gene

    Size:
    712 amino acids
    Molecular mass:
    81185 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP44 Gene

Proteomics data for USP44 Gene at MOPED

Selected DME Specific Peptides for USP44 Gene

Post-translational modifications for USP44 Gene

Domains for USP44 Gene

Gene Families for USP44 Gene

HGNC:
  • USP :Ubiquitin-specific peptidases

UniProtKB/Swiss-Prot:

UBP44_HUMAN
Domain:
  • Contains 1 USP domain.:
    • Q9H0E7
Family:
  • Belongs to the peptidase C19 family. USP44 subfamily.:
    • Q9H0E7
Similarity:
  • Contains 1 UBP-type zinc finger.:
    • Q9H0E7
genes like me logo Genes that share domains with USP44: view

Function for USP44 Gene

Molecular function for USP44 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.
UniProtKB/Swiss-Prot Induction: Transcriptionally regulated by POU5F1/OCT4 in embryonic stem cells and embryonal carcinoma cells.

Enzyme Numbers (IUBMB) for USP44 Gene

Gene Ontology (GO) - Molecular Function for USP44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0004221 ubiquitin thiolesterase activity --
GO:0004843 ubiquitin-specific protease activity IDA 14715245
GO:0005515 protein binding IPI 17443180
GO:0008234 cysteine-type peptidase activity --
genes like me logo Genes that share ontologies with USP44: view

Phenotypes for USP44 Gene

MGI mutant phenotypes for USP44:
inferred from 3 alleles
GenomeRNAi human phenotypes for USP44:
genes like me logo Genes that share phenotypes with USP44: view

Animal Models for USP44 Gene

MGI Knock Outs for USP44:

miRNA for USP44 Gene

miRTarBase miRNAs that target USP44

No data available for Transcription Factor Targeting and HOMER Transcription for USP44 Gene

Localization for USP44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP44 Gene

Nucleus. Note=Peaks in interphase, with relatively low levels maintained throughout mitosis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP44 Gene COMPARTMENTS Subcellular localization image for USP44 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for USP44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with USP44: view

Pathways for USP44 Gene

genes like me logo Genes that share pathways with USP44: view

Pathways by source for USP44 Gene

1 Qiagen pathway for USP44 Gene

Gene Ontology (GO) - Biological Process for USP44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0007067 mitotic nuclear division IEA --
GO:0016579 protein deubiquitination IDA 14715245
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with USP44: view

Transcripts for USP44 Gene

Unigene Clusters for USP44 Gene

Ubiquitin specific peptidase 44:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP44 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - -
SP2: - - -
SP3:
SP4: - - - - - -
SP5: -
SP6: - -

Relevant External Links for USP44 Gene

GeneLoc Exon Structure for
USP44
ECgene alternative splicing isoforms for
USP44

Expression for USP44 Gene

mRNA expression in normal human tissues for USP44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP44 Gene

This gene is overexpressed in Testis (10.1) and Brain - Cerebellar Hemisphere (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for USP44 Gene

SOURCE GeneReport for Unigene cluster for USP44 Gene Hs.646421

mRNA Expression by UniProt/SwissProt for USP44 Gene

Q9H0E7-UBP44_HUMAN
Tissue specificity: Expressed in testis. Expressed at high levels in T-cell acute lymphoblastic leukemia.
genes like me logo Genes that share expressions with USP44: view

Orthologs for USP44 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP44 36
  • 99.44 (n)
  • 99.02 (a)
USP44 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia USP44 36
  • 90.15 (n)
  • 90.24 (a)
USP44 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP44 36
  • 90.89 (n)
  • 90.42 (a)
USP44 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp44 36
  • 82.11 (n)
  • 80.65 (a)
Usp44 16
Usp44 37
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia USP44 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP44 37
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP44 36
  • 73.47 (n)
  • 75.25 (a)
USP44 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP44 37
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10183 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10247 36
usp44 36
  • 72.87 (n)
  • 74.8 (a)
zebrafish
(Danio rerio)
Actinopterygii usp44 36
  • 62.78 (n)
  • 69.44 (a)
usp44 37
  • 66 (a)
OneToOne
zgc55661 36
worm
(Caenorhabditis elegans)
Secernentea E01B7.1 37
  • 13 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DOA4 37
  • 14 (a)
ManyToMany
UBP5 37
  • 16 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3289 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 43 (a)
OneToMany
Species with no ortholog for USP44:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP44 Gene

ENSEMBL:
Gene Tree for USP44 (if available)
TreeFam:
Gene Tree for USP44 (if available)

Paralogs for USP44 Gene

Paralogs for USP44 Gene

Selected SIMAP similar genes for USP44 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with USP44: view

Variants for USP44 Gene

Sequence variations from dbSNP and Humsavar for USP44 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs188523 -- 95,523,067(-) GGTGC(C/T)GCCCT intron-variant
rs300999 -- 95,524,205(-) TGCTC(A/G)GGAGG intron-variant
rs301000 -- 95,523,191(-) acctt(C/T)gtgtt intron-variant
rs301001 -- 95,523,180(-) TACCC(A/G)TTTAT intron-variant
rs301002 -- 95,522,707(-) TCTGC(C/G)TCCCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP44 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
dgv1482n71 CNV Loss 21882294
nsv528896 CNV Gain 19592680

Relevant External Links for USP44 Gene

HapMap Linkage Disequilibrium report
USP44
Human Gene Mutation Database (HGMD)
USP44

Disorders for USP44 Gene

Relevant External Links for USP44

Genetic Association Database (GAD)
USP44
genes like me logo Genes that share disorders with USP44: view

No data available for UniProtKB/Swiss-Prot for USP44 Gene

Publications for USP44 Gene

  1. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. (PMID: 17443180) Stegmeier F. … Elledge S.J. (Nature 2007) 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 3 4

Products for USP44 Gene

Sources for USP44 Gene

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