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USP44 Gene

protein-coding   GIFtS: 53
GCID: GC12M095910

Ubiquitin Specific Peptidase 44

(Previous name: ubiquitin specific protease 44)
  Search for USP44
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 441 2     Ubiquitin Carboxyl-Terminal Hydrolase 442
Ubiquitin Specific Protease 441 2     Ubiquitin Thiolesterase 442
Deubiquitinating Enzyme 442 3     EC 3.4.19.123
Ubiquitin Thioesterase 442 3     EC 3.1.2.158
Ubiquitin-Specific-Processing Protease 442 3     

External Ids:    HGNC: 200641   Entrez Gene: 841012   Ensembl: ENSG000001360147   OMIM: 6109935   UniProtKB: Q9H0E73   

Export aliases for USP44 gene to outside databases

Previous GC identifers: GC12M095844 GC12M094414 GC12M094397 GC12M094435 GC12M092979


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USP44 Gene:
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated
action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP44 belongs to a large family of
cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 (PubMed 14715245)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for USP44 Gene:
USP44 (ubiquitin specific peptidase 44) is a protein-coding gene. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP3.

UniProtKB/Swiss-Prot: UBP44_HUMAN, Q9H0E7
Function: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint
by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative
regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the
MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature
activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly
checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination

Gene Wiki entry for USP44 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP44 gene promoter:
         GR   SRY   POU2F1   GR-beta   GR-alpha   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): USP44 promoter sequence
   Search Chromatin IP Primers for USP44

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP44


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22   Ensembl cytogenetic band:  12q22   HGNC cytogenetic band: 12q21.33

USP44 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP44 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M095910:  view genomic region     (about GC identifiers)

Start:
95,910,336 bp from pter      End:
95,945,266 bp from pter
Size:
34,931 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBP44_HUMAN, Q9H0E7 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 44  
Size: 712 amino acids; 81185 Da
Developmental stage: Elevated in mitosis; levels increase in mitotic cells and rapidly decrease once cells have
completed chromosome attachment and exit from mitosis
Secondary accessions: B2RDW3

Explore the universe of human proteins at neXtProt for USP44: NX_Q9H0E7

Explore proteomics data for USP44 at MOPED

Post-translational modifications: 

  • Dephosphorylated by CTDP11
  • Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination and is degraded by the proteasome1
  • Modification sites at neXtProt
  • 2 DME Specific Peptides for USP44 (Q9H0E7)
     QQDAQEFL  NLGNTCYMN 


    See USP44 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035862.1  NP_001265322.1  NP_115523.2  

    ENSEMBL proteins: 
     ENSP00000258499   ENSP00000376806   ENSP00000448670   ENSP00000442629   ENSP00000448601  
     ENSP00000449635  

    USP44 Human Recombinant Protein Products:

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    GenScript Custom Purified and Recombinant Proteins Services for USP44
    Novus Biologicals USP44 Protein
    Novus Biologicals USP44 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP44

     
    Search eBioscience for Proteins for USP44 

    USP44 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for USP44
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    Search ThermoFisher Antibodies for USP44
    LSBio Antibodies in human, mouse, rat for USP44

    USP44 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP44
    Cloud-Clone Corp. CLIAs for USP44
    Search eBioscience for ELISAs for USP44 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    5 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR013083 Znf_RING/FYVE/PHD
     IPR028889 UCH/PAN2
     IPR001607 Znf_UBP

    Graphical View of Domain Structure for InterPro Entry Q9H0E7

    ProtoNet protein and cluster: Q9H0E7

    2 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB001607 Zn-finger in ubiquitin thiolesterase


    UniProtKB/Swiss-Prot: UBP44_HUMAN, Q9H0E7
    Similarity: Belongs to the peptidase C19 family. USP44 subfamily
    Similarity: Contains 1 UBP-type zinc finger
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP44           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP44_HUMAN, Q9H0E7
    Function: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint
    by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative
    regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the
    MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature
    activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly
    checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Induction: Transcriptionally regulated by POU5F1/OCT4 in embryonic stem cells and embryonal carcinoma cells

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IMP17443180
    GO:0004843ubiquitin-specific protease activity IDA14715245
    GO:0005515protein binding IPI17443180
    GO:0008234cysteine-type peptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with USP44           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for USP44:
     Cell cycle / mitosis defect 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Usp44):
     cellular  no phenotypic analysis  tumorigenesis 

    Find genes that share phenotypes with USP44           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Usp44tm1.2Pjgl for USP44

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP44
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP44

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP44
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP44

    miRNA
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    miRTarBase miRNAs that target USP44:
    hsa-mir-335-5p (MIRT017223)

    Block miRNA regulation of human, mouse, rat USP44 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP44 (see all 29):
    hsa-miR-320a hsa-miR-30c hsa-let-7d hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-miR-30d hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidUSP44 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat USP44

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for USP44
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): USP44 (NM_001042403)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP44
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP44
    Addgene plasmids for USP44 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for USP44 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP44


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBP44_HUMAN, Q9H0E7: Nucleus. Note=Peaks in interphase, with relatively low levels maintained throughout mitosis
    (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    Find genes that share ontologies with USP44           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP44 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP44
        Ubiquitin-Proteasome Dependent Proteolysis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP44
    Interactions:

        Search GeneGlobe Interaction Network for USP44

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP44 (Q9H0E73 ENSP000002584994) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CETN2P412083, ENSP000003593004I2D: score=2 STRING: ENSP00000359300
    KRR1Q136013, ENSP000002292144I2D: score=2 STRING: ENSP00000229214
    MRPL23Q165403, ENSP000003709304I2D: score=2 STRING: ENSP00000370930
    POLR2GP624873, ENSP000003017884I2D: score=2 STRING: ENSP00000301788
    SARS2Q9NP813, ENSP000002214314I2D: score=2 STRING: ENSP00000221431
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0007067mitosis IEA--
    GO:0016579protein deubiquitination IDA14715245
    GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process ISS--
    GO:0051322anaphase IMP17443180

    Find genes that share ontologies with USP44           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP44 (UBP44)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP44 gene (3 alternative transcripts): 
    NM_001042403.2  NM_001278393.1  NM_032147.3  

    Unigene Cluster for USP44:

    Ubiquitin specific peptidase 44
    Hs.646421  [show with all ESTs]
    Unigene Representative Sequence: NM_032147
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258499(uc009zte.3 uc001teg.3 uc001teh.3) ENST00000393091
    ENST00000552440 ENST00000537435 ENST00000552237 ENST00000551837 ENST00000549639
    ENST00000547951
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP44 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP44 (see all 29):
    hsa-miR-320a hsa-miR-30c hsa-let-7d hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-miR-30d hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidUSP44 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat USP44
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): USP44 (NM_001042403)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP44
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP44
    Addgene plasmids for USP44 
    Primer
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    OriGene qPCR primer pairs and template standards for USP44
    OriGene qSTAR qPCR primer pairs in human, mouse for USP44
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP44
      QuantiTect SYBR Green Assays in human, mouse, rat USP44
      QuantiFast Probe-based Assays in human, mouse, rat USP44

    Additional mRNA sequence: 

    AK027434.1 AK315697.1 AL136825.1 BC030704.1 

    4 DOTS entries:

    DT.100009241  DT.206996  DT.95225780  DT.95201214 

    Selected AceView cDNA sequences (see all 38):

    BM021157 CD642865 BM023146 AA232294 BC030704 AA641937 BU561433 BM021418 
    BQ429545 AW274278 BU568345 BI560025 AA641888 AA448146 BG722436 BI459992 
    AA448003 BU854466 BI560712 BI832035 D61996 CD655048 AI927881 AK027434 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for USP44 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:                    -     -     -     -                                         -               
    SP2:                    -     -     -                                                               
    SP3:                                                                                                
    SP4:        -     -     -     -     -     -                                                         
    SP5:                          -                                                                     


    ECgene alternative splicing isoforms for USP44

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP44 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAAAATGA
    USP44 Expression
    About this image


    USP44 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             N2/LSB/S/F8-induced cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 5 entries
             Human embryonic stem cells (family)
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    USP44 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP44 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.646421

    UniProtKB/Swiss-Prot: UBP44_HUMAN, Q9H0E7
    Tissue specificity: Expressed in testis. Expressed at high levels in T-cell acute lymphoblastic leukemia

        Custom PCR Arrays for USP44
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    QuantiFast Probe-based Assays in human, mouse, rat USP44
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP44

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP44 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp441 , 5 ubiquitin specific peptidase 441, 5 82.11(n)1
    80.65(a)1
      10 (48.67 cM)5
    3277991  NM_001206851.11  NP_001193780.11 
     938315555 
    chicken
    (Gallus gallus)
    Aves USP441 ubiquitin specific peptidase 44 73.47(n)
    75.25(a)
      417913  XM_004937641.1  XP_004937698.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP446
    ubiquitin specific peptidase 44
    72(a)
    1 ↔ 1
    5(30774722-30785361)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.101832 Xenopus laevis transcribed sequence with moderate similarity more 79.42(n)    BX850520.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc556612 hypothetical protein MGC55661 74.24(n)   393227  BC048060.1 
    worm
    (Caenorhabditis elegans)
    Secernentea E01B7.16
    Protein E01B7.1 (E01B7.1) mRNA, complete cds
    13(a)
    many ↔ many
    V(17924916-17934227) WBGene00008441
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP56
    DOA46
    Putative ubiquitin-specific protease, closest para...
    Ubiquitin isopeptidase, required for recycling ubi...
    16(a)
    14(a)
    many ↔ many
    many ↔ many
    V(457806-460223) YER144C
    IV(584939-587719) YDR069C


    ENSEMBL Gene Tree for USP44 (if available)
    TreeFam Gene Tree for USP44 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP44 gene
    USP32  USP212  USP82  USP492  USP22  USP502  
    6 SIMAP similar genes for USP44 using alignment to 4 protein entries:     UBP44_HUMAN (see all proteins):
    USP49    BRAP    DKFZp566E044    HDAC6    USP33    USP3

    Find genes that share paralogs with USP44           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP44 (see all 809)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115488541,2
    Cuntested195927820(-) TTGGAA/G/TGTGAA 4 E D mis1 ese30--------
    rs170243341,2
    C,F,H--95910476(+) TGTCTA/GTTCAG 2 -- ds500110Minor allele frequency- G:0.03NA NS WA 1054
    rs1379163491,2
    --95910502(+) TGCAC-/CTCA  
            
    CTATC
    2 -- ds50010--------
    rs1500344741,2
    C--95910624(+) GGATA-/CTAT  
            
    CTATC
    2 -- ds50010--------
    rs170243361,2
    C,F,H--95910631(+) TATCTT/GTCACT 2 -- ds500115Minor allele frequency- G:0.03NA NS EA WA 1492
    rs1816591701,2
    --95910716(+) TACATA/GGCTGG 2 -- ds50010--------
    rs1853922251,2
    --95910744(+) ATTCTA/GCCCTC 2 -- ds50010--------
    rs1445710651,2
    C--95910836(+) CTGTA-/T/    
       TTTAT
    TTTTT
    2 -- ds50010--------
    rs3010251,2
    C,F,O,A,H--95910846(-) TTGCAA/CAAAAA 2 -- ds500111Minor allele frequency- C:0.34NA WA EA 512
    rs1913199211,2
    --95910878(+) TTTTTG/TTTTTT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for USP44 (95910336 - 95945266 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for USP44:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1482n71CNV Loss21882294
    nsv528896CNV Gain19592680
    nsv7234OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): USP44
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP44
    DNA2.0 Custom Variant and Variant Library Synthesis for USP44

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610993    OMIM disorders: --


    Find genes that share disorders with USP44           About GenesLikeMe

    Genetic Association Database (GAD): USP44

    Export disorders for USP44 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP44 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with USP44)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. (PubMed id 17443180)1, 2, 9 Stegmeier F.... Elledge S.J. (Nature 2007)
    2. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PubMed id 22041458)1, 4 Clark S.L....van den Oord E.J. (Psychol Med 2012)
    3. Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit. (PubMed id 22692537)1, 2 Visconti R.... Grieco D. (Nat. Commun. 2012)
    4. Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia. (PubMed id 21853124)1, 2 Zhang Y.... Galardy P.J. (PLoS ONE 2011)
    5. K48- and K63-linked polyubiquitination of deubiquitinating enzyme USP44. (PubMed id 20402667)1, 2 Suresh B....Baek K.H. (Cell Biol. Int. 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004)
    9. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84101 HGNC: 20064 AceView: USP44 Ensembl:ENSG00000136014 euGenes: HUgn84101
    ECgene: USP44 H-InvDB: USP44

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP44 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP44 gene:
    Search GeneIP for patents involving USP44

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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