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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

USP44 Gene

protein-coding GIFtS: 51
GCID: GC12M095910

ubiquitin specific peptidase 44

(Previous name: ubiquitin specific protease 44 )

Explore 5 diseases affiliated with
USP44 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 44¹ ²		FLJ14528¹
Ubiquitin Specific Protease 44¹ ²		Ubiquitin Carboxyl-Terminal Hydrolase 44²
Deubiquitinating Enzyme 44² ³		Ubiquitin Thiolesterase 44²
Ubiquitin Thioesterase 44² ³		EC 3.4.19.12³
Ubiquitin-Specific-Processing Protease 44² ³		EC 3.1.2.15⁸

External Ids:	HGNC: 20064¹	Entrez Gene: 84101²	Ensembl: ENSG00000136014⁷	OMIM: 610993⁵	UniProtKB: Q9H0E7³

Export aliases for USP44 gene to outside databases

Previous GC identifers: GC12M095844 GC12M094414 GC12M094397 GC12M094435 GC12M092979

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for USP44:

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated

action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP44 belongs to a large family of cysteine

proteases that function as deubiquitinating enzymes (Quesada et al., 2004 (PubMed 14715245)).(supplied by OMIM, Mar

2008)

UniProtKB/Swiss-Prot: UBP44_HUMAN, Q9H0E7

Function: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by

preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of

the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C

ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C.

Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator

of histone H2B (H2BK120ub1) ubiquitination

Gene Wiki entry for USP44

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the USP44 gene promoter:
GR SRY POU2F1 GR-beta GR-alpha GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): USP44 promoter sequence

Search SABiosciences Chromatin IP Primers for USP44

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP44

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22 Ensembl cytogenetic band: 12q22 HGNC cytogenetic band: 12q21.33

USP44 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP44 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M095910: view genomic region (about GC identifiers)

Start:	95,910,336 bp from pter	End:	95,945,266 bp from pter
Size:	34,931 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UBP44_HUMAN, Q9H0E7 (See protein sequence)

Recommended Name: Ubiquitin carboxyl-terminal hydrolase 44

Size: 712 amino acids; 81185 Da

Subcellular location: Nucleus. Note=Peaks in interphase, with relatively low levels maintained throughout mitosis (By

similarity)

Developmental stage: Elevated in mitosis; levels increase in mitotic cells and rapidly decrease once cells have

completed chromosome attachment and exit from mitosis

Secondary accessions: B2RDW3

Explore the universe of human proteins at neXtProt for USP44: NX_Q9H0E7

Post-translational modifications:

Dephosphorylated by CTDP1¹

Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination and is degraded by the proteasome¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H0E7

2 DME Specific Peptides for USP44 (Q9H0E7)

QQDAQEFL

NLGNTCYMN

USP44 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001035862.1 NP_115523.2

ENSEMBL proteins:

ENSP00000258499 ENSP00000376806 ENSP00000448670 ENSP00000442629 ENSP00000448601

ENSP00000449635

Human Recombinant Protein Products:

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	Novus Biologicals USP44 Protein Novus Biologicals USP44 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for USP44

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--

USP44 for ontologies About GeneDecksing

USP44 Antibody Products:

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	Uscn ELISAs and CLIAs for USP44

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

USP44 for domains About GeneDecksing

4 InterPro domains/families:

IPR001394 Peptidase_C19

IPR001607 Znf_UBP

IPR018200 Pept_C19ubi-hydrolase_C_CS

IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q9H0E7

ProtoNet protein and cluster: Q9H0E7

2 Blocks protein families:

IPB001394 Ubiquitin thiolesterase

IPB001607 Zn-finger in ubiquitin thiolesterase

UniProtKB/Swiss-Prot: UBP44_HUMAN, Q9H0E7

Similarity: Belongs to the peptidase C19 family. USP44 subfamily

Similarity: Contains 1 UBP-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: UBP44_HUMAN, Q9H0E7

Function: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by

preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of

the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C

ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C.

Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator

of histone H2B (H2BK120ub1) ubiquitination

Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the

C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

Induction: Transcriptionally regulated by POU5F1/OCT4 in embryonic stem cells and embryonal carcinoma cells

Enzyme Numbers (IUBMB): EC 3.1.2.15² EC 3.4.19.12¹

miRNA Products:		OriGene 3'-UTR Clone (see all 2): USP44 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP44
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate USP44 (see all 29):
		hsa-miR-320a hsa-miR-30c hsa-let-7d hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-miR-30d hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: USP44 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP44

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004221	ubiquitin thiolesterase activity	IMP	--
GO:0004843	ubiquitin-specific protease activity	IDA	--
GO:0005515	protein binding	IPI	17443180
GO:0008234	cysteine-type peptidase activity	--	--
GO:0008270	zinc ion binding	IEA	--

USP44 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for USP44:

Cell cycle / mitosis defect

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitin-Proteasome Dependent Proteolysis

Ubiquitin-Proteasome Dependent Proteolysis

1.00

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP44

Ubiquitin-Proteasome Dependent Proteolysis

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for USP44

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/14 Interacting proteins for USP44 (Q9H0E7³ ENSP00000258499⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CETN2	P41208³, ENSP00000359300⁴	I2D: score=2 STRING: ENSP00000359300
KRR1	Q13601³, ENSP00000229214⁴	I2D: score=2 STRING: ENSP00000229214
MRPL23	Q16540³, ENSP00000370930⁴	I2D: score=2 STRING: ENSP00000370930
POLR2G	P62487³, ENSP00000301788⁴	I2D: score=2 STRING: ENSP00000301788
SARS2	Q9NP81³, ENSP00000221431⁴	I2D: score=2 STRING: ENSP00000221431

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006511	ubiquitin-dependent protein catabolic process	--	--
GO:0007067	mitosis	IEA	--
GO:0016579	protein deubiquitination	IDA	--
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	ISS	--
GO:0051301	cell division	IEA	--

USP44 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for USP44
Search CenterWatch for drugs/clinical trials and news about USP44 / UBP44

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for USP44 gene (2 alternative transcripts):

NM_001042403.1 NM_032147.2

Unigene Cluster for USP44:

Ubiquitin specific peptidase 44

Hs.646421 [show with all ESTs]

Unigene Representative Sequence: NM_032147

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000258499(uc009zte.3 uc001teg.3 uc001teh.3) ENST00000393091

ENST00000552440 ENST00000537435 ENST00000552237 ENST00000551837 ENST00000549639

ENST00000547951

miRNA Products:		OriGene 3'-UTR Clone (see all 2): USP44 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP44
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate USP44 (see all 29):
		hsa-miR-320a hsa-miR-30c hsa-let-7d hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-miR-30d hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: USP44 3' UTR sequence

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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP44 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP44 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP44
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP44

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP44
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP44

Additional cDNA sequence:

AK027434.1 AK315697.1 AL136825.1 BC030704.1

4 DOTS entries:

DT.100009241 DT.206996 DT.95225780 DT.95201214

24/38 AceView cDNA sequences (see all 38):

AA232294 BM021157 CD642865 BM023146 AI927881 AA641937 AW274278 BI832035

BU182596 BM021418 AA448146 AK027434 BI560712 BU561433 BU568345 BU854466

BI560025 BC030704 BI459992 D61996 BQ429545 AA448003 BG722436 AA641888

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for USP44 (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d	^	8	^	9a	·	9b	^	10	^	11
SP1:							-		-		-		-														-
SP2:							-		-		-
SP3:
SP4:			-		-		-		-		-		-
SP5:									-

ECgene alternative splicing isoforms for USP44

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

USP44 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAAAATGA

About this image

USP44 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

CyT49 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

ES04(HES-4) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Line H7 (WA07) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

N2/LSB/S/F8-induced cells (Generation of midbra...)

Matrigel embedded cells (Derivation of cardio...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See USP44 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP44

SOURCE GeneReport for Unigene cluster: Hs.646421

UniProtKB/Swiss-Prot: UBP44_HUMAN, Q9H0E7

Tissue specificity: Expressed in testis. Expressed at high levels in T-cell acute lymphoblastic leukemia

SABiosciences Custom PCR Arrays for USP44

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP44

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP44

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP44 gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	USP44¹	ubiquitin specific peptidase 44	73.51(n) 75.46(a)		417913 XM_416154.3 XP_416154.2
lizard (Anolis carolinensis)	Reptilia	USP44⁶	--	72(a)	1 ↔ 1	5(30774776-30785361)
African clawed frog (Xenopus laevis)	Amphibia	Xl.10183²	Xenopus laevis transcribed sequence with moderate similarity more	79.42(n)		BX850520.1
zebrafish (Danio rerio)	Actinopterygii	zgc55661²	hypothetical protein MGC55661	74.24(n)		393227 BC048060.1
worm (Caenorhabditis elegans)	Secernentea	usp-33⁶	Ubiquitin carboxyl-terminal hydrolase	14(a)	1 → many	X(15591300-15595286)
thale cress (Arabidopsis thaliana)	eudicotyledons	UBP16⁶ UBP25⁶ (see all 6)	ubiquitin carboxyl-terminal hydrolase 25 (see all 6)	9(a) 15(a) (see all 6)	possible ortholog possible ortholog (see all 6)	4(12679210-12684939) 3(4811532-4815515)
rice (Oryza sativa)	Liliopsida	-- -- (see all 5)	ubiquitin carboxyl-terminal hydrolase family prote... ubiquitin carboxyl-terminal hydrolase domain conta... (see all 5)	9(a) 15(a) (see all 5)	possible ortholog possible ortholog (see all 5)	6(26784111-26791029) 5(25211790-25217569)

ENSEMBL Gene Tree for USP44 (if available)
TreeFam Gene Tree for USP44 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for USP44 gene

USP33² USP3² USP45² USP22² USP51² USP16² USP49² USP20²

6 SIMAP similar genes for USP44 using alignment to 4 protein entries: UBP44_HUMAN (see all proteins):

USP49 BRAP DKFZp566E044 HDAC6 USP33 USP3

USP44 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs36010747^1,2	C	--	92985040(+)	`AAAAA-/AGTGTG`	1	--	int¹		1		NA	2
rs17024334^1,2	C,F,H,	--	95910476(+)	`TGTCTA/GTTCAG`	2	--	ds500¹		10		NA NS WA	1054
rs137916349^1,2		--	95910502(+)	`TGCAC-/CTCA CTATC`	2	--	ds500¹		0	--	--	--	--
rs150034474^1,2	C,	--	95910624(+)	`GGATA-/CTAT CTATC`	2	--	ds500¹		0	--	--	--	--
rs17024336^1,2	C,F,H,	--	95910631(+)	`TATCTT/GTCACT`	2	--	ds500¹		15		NA NS EA WA	1492
rs181659170^1,2		--	95910716(+)	`TACATA/GGCTGG`	2	--	ds500¹		0	--	--	--	--
rs185392225^1,2		--	95910744(+)	`ATTCTA/GCCCTC`	2	--	ds500¹		0	--	--	--	--
rs144571065^1,2		--	95910835(+)	`CTGTA-/TTTTTT`	2	--	ds500¹		0	--	--	--	--
rs301025^1,2	C,F,O,A,H,	--	95910846(-)	`TTGCAA/CAAAAA`	2	--	ds500¹		11		NA WA EA	512
rs191319921^1,2		--	95910878(+)	`TTTTTG/TTTTTT`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for USP44 (95910336 - 95945266 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for USP44: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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USP44 for disorders           About GeneDecksing

OMIM gene information: 610993    OMIM disorders: --

5 diseases for USP44:    About MalaCards

embryonal carcinoma t-cell leukemia leukemia carcinoma

malaria

Export disorders for USP44 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for USP44 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with USP44)

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Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. (PubMed id 17443180)^{1, 2, 9} Stegmeier F....Elledge S.J. (2007)
Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit. (PubMed id 22692537)^{1, 2} Visconti R.... Grieco D. (2012)
Overexpression of ubiquitin specific protease 44 (USP 44) induces chromosomal instability and is frequently observed in human T-cell leukemia. (PubMed id 21853124)^{1, 2} Zhang Y....Galardy P.J. (2011)
K48- and K63-linked polyubiquitination of deubiquitinating enzyme USP44. (PubMed id 20402667)^{1, 2} Suresh B....Baek K.H. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)^{1, 2} Quesada V.... Lopez-Otin C. (2004)
Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)^{1, 3} Puente X.S.... Lopez-Otin C. (2003)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
Pharmacogenomic study of side-effects for antidepressa nt treatment options in STAR*D. (PubMed id 22041458)¹ Clark S.L....van den Oord E.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84101	HGNC: 20064	AceView: USP44	Ensembl:ENSG00000136014	euGenes: HUgn84101
ECgene: USP44	H-InvDB: USP44

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for USP44	Pharmacogenomics, SNPs, Pathways

Intellectual Property for USP44 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for USP44 gene:
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USP44 Gene

ubiquitin specific peptidase 44

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USP44 Gene

ubiquitin specific peptidase 44

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