Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP44 Gene

protein-coding   GIFtS: 52
GCID: GC12M095910

Ubiquitin Specific Peptidase 44

(Previous name: ubiquitin specific protease 44)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 441 2     Ubiquitin Carboxyl-Terminal Hydrolase 442
Ubiquitin Specific Protease 441 2     Ubiquitin Thiolesterase 442
Deubiquitinating Enzyme 442 3     EC 3.4.19.123
Ubiquitin Thioesterase 442 3     EC 3.1.2.158
Ubiquitin-Specific-Processing Protease 442 3     

External Ids:    HGNC: 200641   Entrez Gene: 841012   Ensembl: ENSG000001360147   OMIM: 6109935   UniProtKB: Q9H0E73   

Export aliases for USP44 gene to outside databases

Previous GC identifers: GC12M095844 GC12M094414 GC12M094397 GC12M094435 GC12M092979


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for USP44 Gene:
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated
action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP44 belongs to a large family of
cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 (PubMed 14715245)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for USP44 Gene: 
USP44 (ubiquitin specific peptidase 44) is a protein-coding gene. Diseases associated with USP44 include t-cell leukemia, and acute lymphoblastic leukemia. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP3.

UniProtKB/Swiss-Prot: UBP44_HUMAN, Q9H0E7
Function: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint
by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative
regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the
MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature
activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly
checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination

Gene Wiki entry for USP44 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP44 gene promoter:
         GR   SRY   POU2F1   GR-beta   GR-alpha   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): USP44 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP44

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP44


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22   Ensembl cytogenetic band:  12q22   HGNC cytogenetic band: 12q21.33

USP44 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP44 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M095910:  view genomic region     (about GC identifiers)

Start:
95,910,336 bp from pter      End:
95,945,266 bp from pter
Size:
34,931 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP44_HUMAN, Q9H0E7 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 44  
Size: 712 amino acids; 81185 Da
Subcellular location: Nucleus. Note=Peaks in interphase, with relatively low levels maintained throughout mitosis
(By similarity)
Developmental stage: Elevated in mitosis; levels increase in mitotic cells and rapidly decrease once cells have
completed chromosome attachment and exit from mitosis
Secondary accessions: B2RDW3

Explore the universe of human proteins at neXtProt for USP44: NX_Q9H0E7

Explore proteomics data for USP44 at MOPED 

Post-translational modifications:

  • UniProtKB: Dephosphorylated by CTDP1
  • UniProtKB: Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination and is degraded by the proteasome
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H0E7

  • 2 DME Specific Peptides for USP44 (Q9H0E7)
     QQDAQEFL  NLGNTCYMN 

    USP44 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP44 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001035862.1  NP_001265322.1  NP_115523.2  

    ENSEMBL proteins: 
     ENSP00000258499   ENSP00000376806   ENSP00000448670   ENSP00000442629   ENSP00000448601  
     ENSP00000449635  

    Human Recombinant Protein Products for USP44: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for USP44
    OriGene Protein Over-expression Lysate for USP44
    OriGene MassSpec for USP44 
    OriGene Custom Protein Services for USP44
    GenScript Custom Purified and Recombinant Proteins Services for USP44
    Novus Biologicals USP44 Protein
    Novus Biologicals USP44 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP44 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    USP44 for ontologies           About GeneDecksing



    USP44 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for USP44
    GenScript Custom Superior Antibodies Services for USP44
    Novus Biologicals USP44 Antibody
    Abcam antibodies for USP44
    Cloud-Clone Corp. Antibodies for USP44 
    Search ThermoFisher Antibodies for USP44
    Search LSBio for Antibodies for USP44 

    Assay Products for USP44: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP44
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP44
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP44 
    Cloud-Clone Corp. CLIAs for USP44


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    4 InterPro protein domains:
     IPR001394 Peptidase_C19
     IPR001607 Znf_UBP
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9H0E7

    ProtoNet protein and cluster: Q9H0E7

    2 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB001607 Zn-finger in ubiquitin thiolesterase


    UniProtKB/Swiss-Prot: UBP44_HUMAN, Q9H0E7
    Similarity: Belongs to the peptidase C19 family. USP44 subfamily
    Similarity: Contains 1 UBP-type zinc finger


    USP44 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP44_HUMAN, Q9H0E7
    Function: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint
    by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative
    regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the
    MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature
    activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly
    checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Induction: Transcriptionally regulated by POU5F1/OCT4 in embryonic stem cells and embryonal carcinoma cells

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IMP17443180
    GO:0004843ubiquitin-specific protease activity IDA17443180
    GO:0005515protein binding IPI17443180
    GO:0008234cysteine-type peptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    USP44 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for USP44:
     Cell cycle / mitosis defect 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Usp44):
     cellular  no phenotypic analysis  tumorigenesis 

    USP44 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Usp44tm1.2Pjgl for USP44

       inGenious Targeting Laboratory - Custom generated mouse model solutions for USP44 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP44

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP44 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP44 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP44
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate USP44 (see all 29):
    hsa-miR-320a hsa-miR-30c hsa-let-7d hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-miR-30d hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidUSP44 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP44
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP44

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP44
    Sirion Biotech Customized adenovirus for overexpression of USP44

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for USP44 (see all 13)
    OriGene ORF clones in mouse, rat for USP44
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): USP44 (NM_001042403)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP44
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP44
    Sirion Biotech Customized lentivirus for stable overexpression of USP44 
                         Customized lentivirus expression plasmids for stable overexpression of USP44 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for USP44
    Search LifeMap BioReagents cell lines for USP44
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP44


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USP44 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP44
        Ubiquitin-Proteasome Dependent Proteolysis


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP44

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for USP44 (Q9H0E73 ENSP000002584994) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CETN2P412083, ENSP000003593004I2D: score=2 STRING: ENSP00000359300
    KRR1Q136013, ENSP000002292144I2D: score=2 STRING: ENSP00000229214
    MRPL23Q165403, ENSP000003709304I2D: score=2 STRING: ENSP00000370930
    POLR2GP624873, ENSP000003017884I2D: score=2 STRING: ENSP00000301788
    SARS2Q9NP813, ENSP000002214314I2D: score=2 STRING: ENSP00000221431
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0007067mitosis IEA--
    GO:0016579protein deubiquitination IDA17443180
    GO:0043161proteasomal ubiquitin-dependent protein catabolic process ISS--
    GO:0051301cell division IEA--

    USP44 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP44 (UBP44)

    Search CenterWatch for drugs/clinical trials and news about USP44 / UBP44

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP44 gene (3 alternative transcripts): 
    NM_001042403.2  NM_001278393.1  NM_032147.3  

    Unigene Cluster for USP44:

    Ubiquitin specific peptidase 44
    Hs.646421  [show with all ESTs]
    Unigene Representative Sequence: NM_032147
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258499(uc009zte.3 uc001teg.3 uc001teh.3) ENST00000393091
    ENST00000552440 ENST00000537435 ENST00000552237 ENST00000551837 ENST00000549639
    ENST00000547951
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP44
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate USP44 (see all 29):
    hsa-miR-320a hsa-miR-30c hsa-let-7d hsa-miR-202 hsa-miR-25 hsa-let-7c hsa-miR-30d hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidUSP44 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP44
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP44
    Clone
    Products:
         
    OriGene clones in human, mouse for USP44 (see all 13)
    OriGene ORF clones in mouse, rat for USP44
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): USP44 (NM_001042403)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP44
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP44
    Sirion Biotech Customized lentivirus for stable overexpression of USP44 
                         Customized lentivirus expression plasmids for stable overexpression of USP44 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for USP44
    OriGene qSTAR qPCR primer pairs in human, mouse for USP44
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP44
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP44
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP44

    Additional mRNA sequence: 

    AK027434.1 AK315697.1 AL136825.1 BC030704.1 

    4 DOTS entries:

    DT.100009241  DT.206996  DT.95225780  DT.95201214 

    24/38 AceView cDNA sequences (see all 38):

    BM023146 AA232294 BM021157 CD642865 BI832035 BU568345 BI560025 AA641937 
    AA641888 BI560712 CD655048 AA448003 BG722436 AW274278 BC030704 AK027434 
    BU561433 AA448146 BQ429545 BI459992 AI927881 BU854466 D61996 BU182596 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for USP44 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:                    -     -     -     -                                         -               
    SP2:                    -     -     -                                                               
    SP3:                                                                                                
    SP4:        -     -     -     -     -     -                                                         
    SP5:                          -                                                                     


    ECgene alternative splicing isoforms for USP44

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP44 expression in normal human tissues (normalized intensities)      USP44 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAAAATGA
    USP44 Expression
    About this image


    USP44 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 9 entries
             Line H7 (WA07)
             ESI-017   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             N2/LSB/S/F8-induced cells ( Generation of midbrain dopaminergic, forebrain and hypothalamic...
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   

    See USP44 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP44

    SOURCE GeneReport for Unigene cluster: Hs.646421

    UniProtKB/Swiss-Prot: UBP44_HUMAN, Q9H0E7
    Tissue specificity: Expressed in testis. Expressed at high levels in T-cell acute lymphoblastic leukemia

        SABiosciences Custom PCR Arrays for USP44
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for USP44
    OriGene qSTAR qPCR primer pairs in human, mouse for USP44
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP44
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP44
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP44
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP44

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP44 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp441 , 5 ubiquitin specific peptidase 441, 5 82.11(n)1
    80.65(a)1
      10 (48.67 cM)5
    3277991  NM_001206851.11  NP_001193780.11 
     938315555 
    chicken
    (Gallus gallus)
    Aves USP441 ubiquitin specific peptidase 44 73.51(n)
    75.46(a)
      417913  XM_416154.3  XP_416154.2 
    lizard
    (Anolis carolinensis)
    Reptilia USP446
    Ubiquitin carboxyl-terminal hydrolase
    72(a)
    1 ↔ 1
    5(30774722-30785361)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.101832 Xenopus laevis transcribed sequence with moderate similarity more 79.42(n)    BX850520.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc556612 hypothetical protein MGC55661 74.24(n)   393227  BC048060.1 
    worm
    (Caenorhabditis elegans)
    Secernentea usp-336
    Protein USP-33
    18(a)
    1 → many
    X(15591368-15595354)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP86
    Ubiquitin-specific protease that is a component of...
    26(a)
    1 → many
    XIII(716715-718130)


    ENSEMBL Gene Tree for USP44 (if available)
    TreeFam Gene Tree for USP44 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP44 gene
    USP32  USP27X2  USP512  USP222  USP492  
    6 SIMAP similar genes for USP44 using alignment to 4 protein entries:     UBP44_HUMAN (see all proteins):
    USP49    BRAP    DKFZp566E044    HDAC6    USP33    USP3

    USP44 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/809 SNPs in USP44 are shown (see all 809)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115488541,2
    Cuntested195927820(-) TTGGAA/G/TGTGAA 4 E D mis1 ese30--------
    rs170243341,2
    C,F,H--95910476(+) TGTCTA/GTTCAG 2 -- ds500110Minor allele frequency- G:0.03NA NS WA 1054
    rs1379163491,2
    --95910502(+) TGCAC-/CTCA  
            
    CTATC
    2 -- ds50010--------
    rs1500344741,2
    C--95910624(+) GGATA-/CTAT  
            
    CTATC
    2 -- ds50010--------
    rs170243361,2
    C,F,H--95910631(+) TATCTT/GTCACT 2 -- ds500115Minor allele frequency- G:0.03NA NS EA WA 1492
    rs1816591701,2
    --95910716(+) TACATA/GGCTGG 2 -- ds50010--------
    rs1853922251,2
    --95910744(+) ATTCTA/GCCCTC 2 -- ds50010--------
    rs1445710651,2
    C--95910836(+) CTGTA-/T/    
       TTTAT
    TTTTT
    2 -- ds50010--------
    rs3010251,2
    C,F,O,A,H--95910846(-) TTGCAA/CAAAAA 2 -- ds500111Minor allele frequency- C:0.34NA WA EA 512
    rs1913199211,2
    --95910878(+) TTTTTG/TTTTTT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for USP44 (95910336 - 95945266 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for USP44:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1482n71CNV Loss21882294
    nsv528896CNV Gain19592680
    nsv7234OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing USP44
    DNA2.0 Custom Variant and Variant Library Synthesis for USP44

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610993    OMIM disorders: --

    4 diseases for USP44:    About MalaCards
    t-cell leukemia    acute lymphoblastic leukemia    lymphoblastic leukemia    leukemia


    USP44 for disorders           About GeneDecksing

    Genetic Association Database (GAD): USP44

    Export disorders for USP44 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP44 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with USP44)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. (PubMed id 17443180)1, 2, 9 Stegmeier F....Elledge S.J. (2007)
    2. Pharmacogenomic study of side-effects for antidepressa nt treatment options in STAR*D. (PubMed id 22041458)1, 4 Clark S.L....van den Oord E.J. (2012)
    3. Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit. (PubMed id 22692537)1, 2 Visconti R.... Grieco D. (2012)
    4. Overexpression of ubiquitin specific protease 44 (USP 44) induces chromosomal instability and is frequently observed in human T-cell leukemia. (PubMed id 21853124)1, 2 Zhang Y....Galardy P.J. (2011)
    5. K48- and K63-linked polyubiquitination of deubiquitinating enzyme USP44. (PubMed id 20402667)1, 2 Suresh B....Baek K.H. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (2004)
    9. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84101 HGNC: 20064 AceView: USP44 Ensembl:ENSG00000136014 euGenes: HUgn84101
    ECgene: USP44 H-InvDB: USP44

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP44 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP44 gene:
    Search GeneIP for patents involving USP44

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for USP44  
     OriGene qPCR primer pairs and template standards for USP44   OriGene Protein Over-expression Lysate for USP44  
     OriGene MassSpec something-or-other for USP44   OriGene clones in human, mouse for USP44  
     OriGene qSTAR qPCR primer pairs in human, mouse for USP44   OriGene Purified Protein for USP44  
     OriGene ORF clones in mouse, rat for USP44   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for USP44   OriGene Custom Protein Services for USP44  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP44
     QIAGEN SeqTarget long-range PCR primers for resequencing USP44
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP44
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP44
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP44
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP44
     GenScript Custom Purified and Recombinant Proteins Services for USP44 GenScript cDNA clones with any tag delivered in your preferred vector for USP44
     GenScript Custom Assay Services for USP44 GenScript Custom Superior Antibodies Services for USP44
     GenScript Custom overexpressing Cell Line Services for USP44 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in USP44 promoter
     Search Chromatin IP Primers for USP44
     RT2 qPCR Primer Assay in human, mouse, rat USP44
     Search GNC Networks for USP44
     SABiosciences PCR Arrays including human, mouse, rat USP44
     Search Tocris compounds for USP44 (UBP44)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     USP44 antibodies
     USP44 proteins
     USP44 lysates
     Antibodies for USP44
     See all of Abcam's Antibodies, Kits and Proteins for USP44
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for USP44
     Antibodies for USP44
     ELISAs for USP44
     CLIAs for USP44
     Search LifeMap BioReagents cell lines for USP44
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP44
     SwitchGear 3'UTR luciferase reporter plasmids for USP44
     SwitchGear Promoter luciferase reporter plasmids for USP44
     Search ThermoFisher Antibodies for USP44
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP44
     inGenious Targeting Laboratory - Custom generated mouse model solutions for USP44
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP44
    Customized:
     lentivirus for stable overexpression of USP44
     lentivirus expression plasmids for stable overexpression of USP44
     adenovirus for overexpression of USP44
     Search LSBio for Antibodies for USP44
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      USP44 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4