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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP43 Gene

protein-coding   GIFtS: 48
GCID: GC17P009489

Ubiquitin Specific Peptidase 43

(Previous name: ubiquitin specific protease 43)
  Search for USP43
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 431 2     Ubiquitin Carboxyl-Terminal Hydrolase 432
Ubiquitin Specific Protease 431 2     Ubiquitin Thiolesterase 432
Deubiquitinating Enzyme 432 3     EC 3.4.19.123
Ubiquitin Thioesterase 432 3     EC 3.1.2.158
Ubiquitin-Specific-Processing Protease 432 3     

External Ids:    HGNC: 200721   Entrez Gene: 1247392   Ensembl: ENSG000001549147   UniProtKB: Q70EL43   

Export aliases for USP43 gene to outside databases

Previous GC identifers: GC17P009491 GC17P009749


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for USP43 Gene: 
USP43 (ubiquitin specific peptidase 43) is a protein-coding gene. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP45.

UniProtKB/Swiss-Prot: UBP43_HUMAN, Q70EL4
Function: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the
processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP43 gene promoter:
         LHX3b/Lhx3b   NRSF form 1   LCR-F1   NRSF form 2   CBF-C   AREB6   CBF-A   Ik-2   CBF-B   LHX3a/Lhx3a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for USP43

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP43


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p12

USP43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP43 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P009489:  view genomic region     (about GC identifiers)

Start:
9,548,015 bp from pter      End:
9,633,004 bp from pter
Size:
84,990 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP43_HUMAN, Q70EL4 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 43  
Size: 1123 amino acids; 122809 Da
Sequence caution: Sequence=BAB70869.1; Type=Frameshift; Positions=619;
Secondary accessions: A6NDT9 B7ZLT9 B7ZVX5 Q8N2C5 Q96DQ6
Alternative splicing: 4 isoforms:  Q70EL4-1   Q70EL4-2   Q70EL4-3   Q70EL4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP43: NX_Q70EL4

Explore proteomics data for USP43 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q70EL4

  • 2 DME Specific Peptides for USP43 (Q70EL4)
     LIIHLKR  GNTCFMN 

    USP43 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP43 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001254505.1  NP_694942.3  

    ENSEMBL proteins: 
     ENSP00000461467   ENSP00000285199   ENSP00000458963   ENSP00000459328  

    Human Recombinant Protein Products for USP43: 
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    OriGene Protein Over-expression Lysate for USP43
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for USP43
    GenScript Custom Purified and Recombinant Proteins Services for USP43
    Novus Biologicals USP43 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP43 


    USP43 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals USP43 Antibodies
    Abcam antibodies for USP43
    Cloud-Clone Corp. Antibodies for USP43 
    Search ThermoFisher Antibodies for USP43
    LSBio Antibodies in human, mouse, rat for USP43 

    Assay Products for USP43: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for USP43
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    Cloud-Clone Corp. ELISAs for USP43 
    Cloud-Clone Corp. CLIAs for USP43


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    2 InterPro protein domains:
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS

    Graphical View of Domain Structure for InterPro Entry Q70EL4

    ProtoNet protein and cluster: Q70EL4

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP43_HUMAN, Q70EL4
    Similarity: Belongs to the peptidase C19 family


    USP43 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP43_HUMAN, Q70EL4
    Function: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the
    processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity)
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IEA--
    GO:0008234cysteine-type peptidase activity IEA--
         
    USP43 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for USP43:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for USP43 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP43

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP43 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP43 

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate USP43:
    hsa-miR-548am hsa-miR-656 hsa-miR-548x hsa-miR-155 hsa-miR-376c hsa-miR-4282 hsa-miR-874
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for USP43
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP43 (NM_153210)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP43
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP43


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USP43 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP43
        Ubiquitin-Proteasome Dependent Proteolysis


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP43

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/11 Interacting proteins for USP43 (Q70EL42, 3 ENSP000002851994) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3976446 I2D: score=1 
    YWHAEP622583, ENSP000002643354I2D: score=2 STRING: ENSP00000264335
    FN3KRPQ9HA643, ENSP000002693734I2D: score=2 STRING: ENSP00000269373
    MAGI3Q5TCQ93, ENSP000003046044I2D: score=2 STRING: ENSP00000304604
    PDCD2Q163423, ENSP000001672184I2D: score=2 STRING: ENSP00000167218
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--

    USP43 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP43 (UBP43)

    Search CenterWatch for drugs/clinical trials and news about USP43 / UBP43

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP43 gene (2 alternative transcripts): 
    NM_001267576.1  NM_153210.4  

    Unigene Cluster for USP43:

    Ubiquitin specific peptidase 43
    Hs.709621  [show with all ESTs]
    Unigene Representative Sequence: NM_153210
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570827 ENST00000285199 ENST00000570475 ENST00000574408(uc002gma.4 uc010cod.3 uc010vva.2 uc010coe.3)
    ENST00000575346 ENST00000573955(uc002gmc.4)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP43
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate USP43:
    hsa-miR-548am hsa-miR-656 hsa-miR-548x hsa-miR-155 hsa-miR-376c hsa-miR-4282 hsa-miR-874
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP43
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP43
    Clone
    Products:
         
    OriGene clones in human, mouse for USP43 (see all 9)
    OriGene ORF clones in mouse, rat for USP43
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP43 (NM_153210)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP43
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP43
    Sirion Biotech Customized lentivirus for stable overexpression of USP43 
                         Customized lentivirus expression plasmids for stable overexpression of USP43 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for USP43
    OriGene qSTAR qPCR primer pairs in human, mouse for USP43
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP43
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP43
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP43

    Additional mRNA sequence: 

    AJ583817.2 AK055188.1 BC039653.1 BC136368.1 BC144041.1 BC171759.1 BX648526.1 

    6 DOTS entries:

    DT.40296510  DT.100669652  DT.100742709  DT.408414  DT.86845617  DT.91730494 

    24/65 AceView cDNA sequences (see all 65):

    BX095772 BE348232 BC039653 BU683791 AJ583817 AI032899 BM664887 BQ186259 
    BM702192 AW665127 AI460076 AA677708 CA406696 BU608435 BU684845 AI217738 
    BX283353 AX746633 AI032712 AW673231 BU753109 AI203760 AA553984 AW105540 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP43 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAATACTG
    USP43 Expression
    About this image


    See USP43 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP43

    SOURCE GeneReport for Unigene cluster: Hs.709621

    UniProtKB/Swiss-Prot: UBP43_HUMAN, Q70EL4
    Tissue specificity: Expressed in brain, aorta and lung at low levels

        SABiosciences Custom PCR Arrays for USP43
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP43

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for USP43 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp431 , 5 ubiquitin specific peptidase 431, 5 82.27(n)1
    81.7(a)1
      11 (41.13 cM)5
    2168351  NM_173754.41  NP_776115.21 
     678545235 
    chicken
    (Gallus gallus)
    Aves USP436
    ubiquitin specific peptidase 43
    66(a)
    1 ↔ 1
    18(2180734-2183708)
    lizard
    (Anolis carolinensis)
    Reptilia USP436
    Uncharacterized protein
    50(a)
    1 ↔ 1
    2(105789219-105920659)
    zebrafish
    (Danio rerio)
    Actinopterygii usp43a6
    USP43 (1 of 2)6
    ubiquitin specific peptidase 43
    44(a)
    42(a)
    1 ↔ many
    1 ↔ many
    6(18260489-18518477)
    3(25648469-25747094)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG304216
    --
    23(a)
    1 → many
    2R(20631335-20644501)


    ENSEMBL Gene Tree for USP43 (if available)
    TreeFam Gene Tree for USP43 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP43 gene
    USP452  USP192  USP62  USP152  USP112  USP162  USP312  USP322  
    USP42  
    1 SIMAP similar gene for USP43 using alignment to 1 protein entry:     UBP43_HUMAN:
    USP31

    USP43 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2166 SNPs in USP43 are shown (see all 2166)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460988171,2
    --9547342(+) TTAAGC/GATGTT 2 -- us2k10--------
    rs23155741,2
    F--9547397(+) TGTAAC/GCCGGT 2 -- us2k10--------
    rs1128070071,2
    C--9547636(+) AGGCTG/-GTCTT 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1398116101,2
    --9547711(+) GCCACC/GGCGCC 2 -- us2k10--------
    rs2001082481,2
    C--9547765(+) AACAA-/CAAGTA 2 -- us2k10--------
    rs113481101,2
    C--9547788(+) GTTAG-/AATACT 2 -- us2k10--------
    rs1112855781,2
    C,F--9547851(+) ATTTTG/ACAAGA 2 -- us2k12Minor allele frequency- A:0.13WA 120
    rs1446079291,2
    C--9547897(+) GGGAT-/AAAGTGA 2 -- us2k10--------
    rs1877012081,2
    --9547946(+) AGGGCA/GGGGCA 2 -- us2k10--------
    rs739757701,2
    C,F--9547991(+) CAAGGA/CTCGTG 2 -- us2k12Minor allele frequency- C:0.02WA 120

    HapMap Linkage Disequilibrium report for USP43 (9548015 - 9633004 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for USP43:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv510697CNV Loss20534489
    nsv833357CNV Loss17160897
    nsv833358CNV Gain17160897
    nsv7289OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing USP43
    DNA2.0 Custom Variant and Variant Library Synthesis for USP43

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    USP43 for disorders           About MalaCards

    USP43 for disorders           About GeneDecksing

    Genetic Association Database (GAD): USP43
    Human Genome Epidemiology (HuGE) Navigator: USP43 (2 documents)

    Export disorders for USP43 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP43 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with USP43)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (2004)
    4. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    5. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 124739 HGNC: 20072 AceView: LOC146845 Ensembl:ENSG00000154914 euGenes: HUgn124739
    ECgene: USP43 H-InvDB: USP43

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP43 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP43 gene:
    Search GeneIP for patents involving USP43

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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