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USP43 Gene

protein-coding   GIFtS: 45
GCID: GC17P009548

Ubiquitin Specific Peptidase 43

(Previous name: ubiquitin specific protease 43)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 431 2     Ubiquitin Carboxyl-Terminal Hydrolase 432
Ubiquitin Specific Protease 431 2     Ubiquitin Thiolesterase 432
Deubiquitinating Enzyme 432 3     EC 3.4.19.123
Ubiquitin Thioesterase 432 3     EC 3.1.2.158
Ubiquitin-Specific-Processing Protease 432 3     

External Ids:    HGNC: 200721   Entrez Gene: 1247392   Ensembl: ENSG000001549147   UniProtKB: Q70EL43   

Export aliases for USP43 gene to outside databases

Previous GC identifers: GC17P009491 GC17P009749 GC17P009489


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for USP43 Gene:
USP43 (ubiquitin specific peptidase 43) is a protein-coding gene. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP45.

UniProtKB/Swiss-Prot: UBP43_HUMAN, Q70EL4
Function: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the
processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the USP43 gene promoter:
         LHX3b/Lhx3b   NRSF form 1   LCR-F1   NRSF form 2   CBF-C   AREB6   CBF-A   Ik-2   CBF-B   LHX3a/Lhx3a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for USP43

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP43


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p12

USP43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP43 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P009548:  view genomic region     (about GC identifiers)

Start:
9,548,015 bp from pter      End:
9,633,008 bp from pter
Size:
84,994 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBP43_HUMAN, Q70EL4 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 43  
Size: 1123 amino acids; 122809 Da
Sequence caution: Sequence=BAB70869.1; Type=Frameshift; Positions=619;
Secondary accessions: A6NDT9 B7ZLT9 B7ZVX5 Q8N2C5 Q96DQ6
Alternative splicing: 4 isoforms:  Q70EL4-1   Q70EL4-2   Q70EL4-3   Q70EL4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP43: NX_Q70EL4

Explore proteomics data for USP43 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for USP43 (Q70EL4)
     LIIHLKR  GNTCFMN 


    See USP43 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001254505.1  NP_694942.3  

    ENSEMBL proteins: 
     ENSP00000458963   ENSP00000285199   ENSP00000459328   ENSP00000477318  

    USP43 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for USP43
    OriGene Custom MassSpec
    OriGene Custom Protein Services for USP43
    GenScript Custom Purified and Recombinant Proteins Services for USP43
    Novus Biologicals USP43 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP43

     
    Search eBioscience for Proteins for USP43 

    USP43 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for USP43
    OriGene Custom Antibody Services for USP43
    Novus Biologicals USP43 Antibodies
    Abcam antibodies for USP43
    Cloud-Clone Corp. Antibodies for USP43
    Search ThermoFisher Antibodies for USP43
    LSBio Antibodies in human, mouse, rat for USP43

    USP43 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP43
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP43
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP43
    Cloud-Clone Corp. CLIAs for USP43
    Search eBioscience for ELISAs for USP43 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    3 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028889 UCH/PAN2

    Graphical View of Domain Structure for InterPro Entry Q70EL4

    ProtoNet protein and cluster: Q70EL4

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP43_HUMAN, Q70EL4
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP43           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP43_HUMAN, Q70EL4
    Function: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the
    processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity)
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity ----
    GO:0008234cysteine-type peptidase activity IEA--
         
    Find genes that share ontologies with USP43           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for USP43:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP43
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP43

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP43
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP43

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat USP43 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate USP43:
    hsa-miR-548am hsa-miR-656 hsa-miR-548x hsa-miR-155 hsa-miR-376c hsa-miR-4282 hsa-miR-874
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP43
    Predesigned siRNA for gene silencing in human, mouse, rat USP43

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP43

    Clone
    Products:
         
    OriGene clones in human, mouse for USP43 (see all 8)
    OriGene ORF clones in mouse, rat for USP43
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP43 (NM_153210)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP43
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP43
    Addgene plasmids for USP43 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for USP43
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP43 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP43


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    cytosol1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP43 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP43
        Ubiquitin-Proteasome Dependent Proteolysis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP43
    Interactions:

        Search GeneGlobe Interaction Network for USP43

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP43 (Q70EL42, 3 ENSP000002851994) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3976446 I2D: score=1 
    YWHAEP622583, ENSP000002643354I2D: score=2 STRING: ENSP00000264335
    FN3KRPQ9HA643, ENSP000002693734I2D: score=2 STRING: ENSP00000269373
    MAGI3Q5TCQ93, ENSP000003046044I2D: score=2 STRING: ENSP00000304604
    PDCD2Q163423, ENSP000001672184I2D: score=2 STRING: ENSP00000167218
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--

    Find genes that share ontologies with USP43           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP43 (UBP43)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP43 gene (2 alternative transcripts): 
    NM_001267576.1  NM_153210.4  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570827 ENST00000570475 ENST00000285199 ENST00000574408(uc002gma.4 uc010cod.3 uc010vva.2 uc010coe.3)
    ENST00000575346 ENST00000573955(uc002gmc.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP43 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate USP43:
    hsa-miR-548am hsa-miR-656 hsa-miR-548x hsa-miR-155 hsa-miR-376c hsa-miR-4282 hsa-miR-874
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for USP43
    Predesigned siRNA for gene silencing in human, mouse, rat USP43
    Clone
    Products:
         
    OriGene clones in human, mouse for USP43 (see all 8)
    OriGene ORF clones in mouse, rat for USP43
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP43 (NM_153210)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP43
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP43
    Addgene plasmids for USP43 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for USP43
    OriGene qSTAR qPCR primer pairs in human, mouse for USP43
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP43
      QuantiTect SYBR Green Assays in human, mouse, rat USP43
      QuantiFast Probe-based Assays in human, mouse, rat USP43

    Selected AceView cDNA sequences (see all 65):

    AW665127 AI460076 BU683791 BC039653 BQ186259 BU684845 AJ583817 BM702192 
    BX095772 BU608435 AI032899 BM664887 BE348232 AA677708 CA406696 H01440 
    NM_145054 AW673231 CB160381 BC025392 AI203760 AK090821 AA553984 BG831111 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP43 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAATACTG
    USP43 Expression
    About this image

    USP43 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP43 Protein Expression

    UniProtKB/Swiss-Prot: UBP43_HUMAN, Q70EL4
    Tissue specificity: Expressed in brain, aorta and lung at low levels

        Custom PCR Arrays for USP43
    Primer
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    OriGene qPCR primer pairs and template standards for USP43
    OriGene qSTAR qPCR primer pairs in human, mouse for USP43
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP43
    QuantiTect SYBR Green Assays in human, mouse, rat USP43
    QuantiFast Probe-based Assays in human, mouse, rat USP43
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP43

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for USP43 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp431 , 5 ubiquitin specific peptidase 431, 5 82.61(n)1
    82.15(a)1
      11 (41.13 cM)5
    2168351  NM_173754.41  NP_776115.21 
     678545235 
    chicken
    (Gallus gallus)
    Aves USP436
    ubiquitin specific peptidase 43
    64(a)
    1 ↔ 1
    18(2180734-2183708)
    lizard
    (Anolis carolinensis)
    Reptilia USP436
    ubiquitin specific peptidase 43
    53(a)
    1 ↔ 1
    2(105789219-105920659)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia usp431 ubiquitin specific peptidase 43 60.77(n)
    55.1(a)
      101734180  XM_004918735.1  XP_004918792.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001492761 ubiquitin carboxyl-terminal hydrolase 43-like 63.18(n)
    62.83(a)
      100149276  XM_001920256.4  XP_001920291.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG304216
    --
    25(a)
    1 → many
    2R(20631335-20644501)


    ENSEMBL Gene Tree for USP43 (if available)
    TreeFam Gene Tree for USP43 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP43 gene
    USP452  USP192  USP62  USP152  USP112  USP162  USP312  USP322  
    USP42  
    1 SIMAP similar gene for USP43 using alignment to 3 protein entries:     UBP43_HUMAN (see all proteins):
    USP31

    Find genes that share paralogs with USP43           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP43 (see all 2166)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460988171,2
    --9547342(+) TTAAGC/GATGTT 2 -- us2k10--------
    rs23155741,2
    F--9547397(+) TGTAAC/GCCGGT 2 -- us2k10--------
    rs1128070071,2
    C--9547636(+) AGGCTG/-GTCTT 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1398116101,2
    --9547711(+) GCCACC/GGCGCC 2 -- us2k10--------
    rs2001082481,2
    C--9547765(+) AACAA-/CAAGTA 2 -- us2k10--------
    rs113481101,2
    C--9547788(+) GTTAG-/AATACT 2 -- us2k10--------
    rs1112855781,2
    C,F--9547851(+) ATTTTG/ACAAGA 2 -- us2k12Minor allele frequency- A:0.13WA 120
    rs1446079291,2
    C--9547897(+) GGGAT-/AAAGTGA 2 -- us2k10--------
    rs1877012081,2
    --9547946(+) AGGGCA/GGGGCA 2 -- us2k10--------
    rs739757701,2
    C,F--9547991(+) CAAGGA/CTCGTG 2 -- us2k12Minor allele frequency- C:0.02WA 120

    HapMap Linkage Disequilibrium report for USP43 (9548015 - 9633008 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for USP43:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510697CNV Loss20534489
    nsv833357CNV Loss17160897
    nsv833358CNV Gain17160897
    nsv7289OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP43
    DNA2.0 Custom Variant and Variant Library Synthesis for USP43

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with USP43           About GenesLikeMe

    Genetic Association Database (GAD): USP43
    Human Genome Epidemiology (HuGE) Navigator: USP43 (2 documents)

    Export disorders for USP43 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP43 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with USP43)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004)
    4. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    5. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 124739 HGNC: 20072 AceView: LOC146845 Ensembl:ENSG00000154914 euGenes: HUgn124739
    ECgene: USP43 H-InvDB: USP43

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP43 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP43 gene:
    Search GeneIP for patents involving USP43

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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