USP43 Gene
protein-coding GIFtS: 47
GCID: GC17P009489
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ubiquitin specific peptidase 43(Previous name: ubiquitin specific protease 43 )
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Aliases
for USP43 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 431 2 | | FLJ306261 | | Ubiquitin Specific Protease 431 2 | | Ubiquitin Carboxyl-Terminal Hydrolase 432 | | Deubiquitinating Enzyme 432 3 | | Ubiquitin Thiolesterase 432 | | Ubiquitin Thioesterase 432 3 | | EC 3.4.19.123 | | Ubiquitin-Specific-Processing Protease 432 3 | | EC 3.1.2.158 |
Export aliases for USP43 gene to outside databasesPrevious GC identifers: GC17P009491 GC17P009749 |
Summaries
for USP43 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UBP43_HUMAN, Q70EL4Function: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processingof poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity)
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Genomic Views
for USP43 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP43 gene promoter:
LHX3b/Lhx3b NRSF form 1 LCR-F1 NRSF form 2 CBF-C AREB6 CBF-A Ik-2 CBF-B LHX3a/Lhx3a
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP43
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP43 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p12USP43 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P009489: view genomic region
(about GC identifiers)
Start:
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9,548,015 bp from pter |
End:
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9,633,004 bp from pter |
Size:
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84,990 bases |
Orientation:
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plus strand |
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Proteins
for USP43 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP43_HUMAN, Q70EL4 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 43 Size: 1123 amino acids; 122809 Da
Sequence caution: Sequence=BAB70869.1; Type=Frameshift; Positions=619;
Secondary accessions: A6NDT9 B7ZLT9 Q8N2C5 Q96DQ6Alternative splicing: 3 isoforms: Q70EL4-1 Q70EL4-2 Q70EL4-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for USP43: NX_Q70EL4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q70EL4
2 DME Specific Peptides for USP43 (Q70EL4)
USP43 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001254505.1 NP_694942.3
ENSEMBL proteins: ENSP00000461467 ENSP00000285199 ENSP00000458963 ENSP00000459328
Human Recombinant Protein Products for USP43:
USP43 Antibody Products:
Assay Products for USP43: |
Protein
Domains /
Families
for USP43 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP43 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q70EL4ProtoNet protein and cluster: Q70EL4 1 Blocks protein family: IPB001394 Ubiquitin thiolesterase
UniProtKB/Swiss-Prot: UBP43_HUMAN, Q70EL4Similarity: Belongs to the peptidase C19 family |
Function
for USP43 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: UBP43_HUMAN, Q70EL4Function: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processingof poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity)Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004221 | ubiquitin thiolesterase activity |
IEA | -- | | GO:0008234 | cysteine-type peptidase activity |
IEA | -- |
USP43 for ontologies About GeneDecksing
Phenotypes:
3 GenomeRNAi human phenotypes for USP43:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP43 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP43 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: USP43 (NM_153210) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP43 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP43 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP43 |
|
Pathways & Interactions
for USP43 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Ubiquitin-Proteasome Dependent Proteolysis | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP43
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP43
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/11 Interacting proteins for USP43 (Q70EL42, 3 ENSP000002851994) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- |
USP43 for ontologies About GeneDecksing
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Drugs & Compounds
for USP43 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USP43
Search CenterWatch for drugs/clinical trials and news about USP43 / UBP43
|
Transcripts
for USP43 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP43 gene (2 alternative transcripts): NM_001267576.1 NM_153210.4 Unigene Cluster for USP43: Ubiquitin specific peptidase 43 Hs.709621 [show with all ESTs]Unigene Representative Sequence: NM_1532106 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000570827 ENST00000285199 ENST00000570475 ENST00000574408(uc002gma.4 uc010cod.3 uc010vva.2 uc010coe.3)
ENST00000575346 ENST00000573955(uc002gmc.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP43 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP43 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: USP43 (NM_153210) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP43 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP43 |
Additional cDNA sequence: AJ583817.2 AK055188.1 BC039653.1 BC136368.1 BC144041.1 BC171759.1 BX648526.1 6 DOTS entries: DT.40296510 DT.100669652 DT.100742709 DT.408414 DT.86845617 DT.91730494 24/65 AceView cDNA sequences (see all 65): BC039653 AJ583817 AA677708 AI032899 AW665127 BQ186259 BU683791 BM702192 BE348232 BM664887 AI460076 BX095772 BU684845 CA406696 BU608435 AA553984 BI830454 AI032712 BX648526 AX746633 CB160381 BG831111 AW750672 AW105540
GeneLoc Exon Structure
|
Expression
for USP43 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP43 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAAATACTG
About this image
See USP43 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP43
SOURCE GeneReport for Unigene cluster: Hs.709621
UniProtKB/Swiss-Prot: UBP43_HUMAN, Q70EL4Tissue specificity: Expressed in brain, aorta and lung at low levels
SABiosciences Custom PCR Arrays for USP43
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP43
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP43 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP43 |
Orthologs
for USP43 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for USP43 gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for USP43 (if available)
TreeFam Gene Tree for USP43 (if available) |
Paralogs
for USP43 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP43 gene
- USP152 USP112 USP312 USP322 USP192 USP42 USP62
3 SIMAP similar genes for USP43 using alignment to 2 protein entries: UBP43_HUMAN (see all proteins):USP15 USP11 USP31
USP43 for paralogs About GeneDecksing
|
Genomic Variants
for USP43 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP43 (9548015 - 9633004 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for USP43: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP43 |
|
Disorders
/ Diseases
for USP43 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP43 for disorders About GeneDecksing
1  disease for USP43: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: USP43 (2 documents)
Export disorders for USP43 gene to outside databases
|
Publications
for USP43 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USP43 gene integrated from 9 sources:
(articles sorted by number of sources associating them with USP43) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (2004)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for USP43 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing USP43 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USP43 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing USP43 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for USP43 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for USP43 gene:
Search GeneIP for patents involving USP43
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for USP43 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for USP43 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP43 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP43 | | | OriGene Protein Over-expression Lysate for USP43 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for USP43 | | OriGene 3'-UTR Clone for USP43 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP43 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP43 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for USP43 | | OriGene Custom Protein Services for USP43 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP43 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP43 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP43 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP43 |
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 |  |  |  | |
| | | | Search Tocris compounds for USP43 |
| |  |  |  |  | | | | |
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 | | | USP43 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP43 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for USP43 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP43 |
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