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Aliases for USP43 Gene

Aliases for USP43 Gene

  • Ubiquitin Specific Peptidase 43 2 3
  • Ubiquitin-Specific-Processing Protease 43 4
  • Ubiquitin Specific Protease 43 2
  • Deubiquitinating Enzyme 43 4
  • Ubiquitin Thioesterase 43 4
  • EC 4
  • EC 64

External Ids for USP43 Gene

Summaries for USP43 Gene

GeneCards Summary for USP43 Gene

USP43 (Ubiquitin Specific Peptidase 43) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include ubiquitin thiolesterase activity and cysteine-type peptidase activity. An important paralog of this gene is USP4.

UniProtKB/Swiss-Prot for USP43 Gene

  • May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP43 Gene

Genomics for USP43 Gene

Genomic Location for USP43 Gene

9,644,698 bp from pter
9,729,691 bp from pter
84,994 bases
Plus strand

Genomic View for USP43 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP43 Gene

Regulatory Elements for USP43 Gene

Proteins for USP43 Gene

  • Protein details for USP43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 43
    Protein Accession:
    Secondary Accessions:
    • A6NDT9
    • B7ZLT9
    • B7ZVX5
    • Q8N2C5
    • Q96DQ6

    Protein attributes for USP43 Gene

    1123 amino acids
    Molecular mass:
    122809 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB70869.1; Type=Frameshift; Positions=619; Evidence={ECO:0000305};

    Alternative splice isoforms for USP43 Gene


neXtProt entry for USP43 Gene

Proteomics data for USP43 Gene at MOPED

Selected DME Specific Peptides for USP43 Gene

Post-translational modifications for USP43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP43 Gene

Domains for USP43 Gene

Gene Families for USP43 Gene

  • USP :Ubiquitin-specific peptidases

Protein Domains for USP43 Gene


  • Contains 1 USP domain.:
    • Q70EL4
  • Belongs to the peptidase C19 family.:
    • Q70EL4
genes like me logo Genes that share domains with USP43: view

Function for USP43 Gene

Molecular function for USP43 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
UniProtKB/Swiss-Prot Function: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Enzyme Numbers (IUBMB) for USP43 Gene

Gene Ontology (GO) - Molecular Function for USP43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0004843 ubiquitin-specific protease activity IBA --
GO:0008234 cysteine-type peptidase activity --
GO:0036459 ubiquitinyl hydrolase activity --
genes like me logo Genes that share ontologies with USP43: view
genes like me logo Genes that share phenotypes with USP43: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for USP43 Gene

Localization for USP43 Gene

Subcellular locations from

Jensen Localization Image for USP43 Gene COMPARTMENTS Subcellular localization image for USP43 gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for USP43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with USP43: view

Pathways for USP43 Gene

genes like me logo Genes that share pathways with USP43: view

Pathways by source for USP43 Gene

1 Qiagen pathway for USP43 Gene

Gene Ontology (GO) - Biological Process for USP43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0016579 protein deubiquitination IBA --
GO:0019985 translesion synthesis TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with USP43: view

Transcripts for USP43 Gene

Unigene Clusters for USP43 Gene

Ubiquitin specific peptidase 43:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP43 Gene

No ASD Table

Relevant External Links for USP43 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP43 Gene

mRNA expression in normal human tissues for USP43 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP43 Gene

SOURCE GeneReport for Unigene cluster for USP43 Gene Hs.709621

mRNA Expression by UniProt/SwissProt for USP43 Gene

Tissue specificity: Expressed in brain, aorta and lung at low levels.
genes like me logo Genes that share expressions with USP43: view

Orthologs for USP43 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP43 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia USP43 36
  • 99.58 (n)
  • 99.55 (a)
USP43 37
  • 100 (a)
(Bos Taurus)
Mammalia USP43 36
  • 82.29 (n)
  • 80.85 (a)
USP43 37
  • 80 (a)
(Canis familiaris)
Mammalia USP43 36
  • 83.07 (n)
  • 79.24 (a)
USP43 37
  • 76 (a)
(Mus musculus)
Mammalia Usp43 36
  • 82.61 (n)
  • 82.15 (a)
Usp43 16
Usp43 37
  • 80 (a)
(Monodelphis domestica)
Mammalia USP43 37
  • 63 (a)
(Rattus norvegicus)
Mammalia Usp43 36
  • 81.88 (n)
  • 80.49 (a)
(Gallus gallus)
Aves USP43 37
  • 64 (a)
(Anolis carolinensis)
Reptilia USP43 37
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia usp43 36
  • 60.77 (n)
  • 55.1 (a)
(Danio rerio)
Actinopterygii LOC100149276 36
  • 63.18 (n)
  • 62.83 (a)
usp43a 37
  • 46 (a)
usp43b 37
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30421 37
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 37 (a)
Species with no ortholog for USP43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP43 Gene

Gene Tree for USP43 (if available)
Gene Tree for USP43 (if available)

Paralogs for USP43 Gene

Paralogs for USP43 Gene

Selected SIMAP similar genes for USP43 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with USP43: view

Variants for USP43 Gene

Sequence variations from dbSNP and Humsavar for USP43 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs169289 -- 9,668,524(-) ACCAG(G/T)GGAAA intron-variant
rs175629 -- 9,647,579(+) ttaTT(C/T)TATCA intron-variant
rs188000 -- 9,670,083(-) ccagc(C/T)tgggt intron-variant
rs190657 -- 9,647,677(+) TTACC(A/C)CAGCA intron-variant
rs190658 -- 9,647,819(+) ctaac(A/C)cggtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP43 Gene

Variant ID Type Subtype PubMed ID
nsv7289 OTHER Inversion 18451855
nsv833357 CNV Loss 17160897
nsv833358 CNV Gain 17160897
nsv510697 CNV Loss 20534489

Relevant External Links for USP43 Gene

HapMap Linkage Disequilibrium report

Disorders for USP43 Gene

Relevant External Links for USP43

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with USP43: view

No data available for UniProtKB/Swiss-Prot for USP43 Gene

Publications for USP43 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for USP43 Gene

Sources for USP43 Gene

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