Free for academic non-profit institutions. Other users need a Commercial license

Aliases for USP43 Gene

Aliases for USP43 Gene

  • Ubiquitin Specific Peptidase 43 2 3 5
  • Ubiquitin-Specific-Processing Protease 43 4
  • Ubiquitin Specific Protease 43 2
  • Deubiquitinating Enzyme 43 4
  • Ubiquitin Thioesterase 43 4
  • EC 4
  • EC 63

External Ids for USP43 Gene

Previous GeneCards Identifiers for USP43 Gene

  • GC17P009491
  • GC17P009749
  • GC17P009489
  • GC17P009548

Summaries for USP43 Gene

GeneCards Summary for USP43 Gene

USP43 (Ubiquitin Specific Peptidase 43) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP4.

UniProtKB/Swiss-Prot for USP43 Gene

  • May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP43 Gene

Genomics for USP43 Gene

Regulatory Elements for USP43 Gene

Enhancers for USP43 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around USP43 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP43 Gene

9,643,493 bp from pter
9,729,691 bp from pter
86,199 bases
Plus strand

Genomic View for USP43 Gene

Genes around USP43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP43 Gene

Proteins for USP43 Gene

  • Protein details for USP43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 43
    Protein Accession:
    Secondary Accessions:
    • A6NDT9
    • B7ZLT9
    • B7ZVX5
    • Q8N2C5
    • Q96DQ6

    Protein attributes for USP43 Gene

    1123 amino acids
    Molecular mass:
    122809 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB70869.1; Type=Frameshift; Positions=619; Evidence={ECO:0000305};

    Alternative splice isoforms for USP43 Gene


neXtProt entry for USP43 Gene

Proteomics data for USP43 Gene at MOPED

Selected DME Specific Peptides for USP43 Gene

Post-translational modifications for USP43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP43 Gene

Domains & Families for USP43 Gene

Gene Families for USP43 Gene

Protein Domains for USP43 Gene

Suggested Antigen Peptide Sequences for USP43 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP43: view

Function for USP43 Gene

Molecular function for USP43 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Enzyme Numbers (IUBMB) for USP43 Gene

Gene Ontology (GO) - Molecular Function for USP43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008234 cysteine-type peptidase activity IEA --
GO:0019785 ISG15-specific protease activity TAS --
genes like me logo Genes that share ontologies with USP43: view
genes like me logo Genes that share phenotypes with USP43: view

Animal Model Products

miRNA for USP43 Gene

miRTarBase miRNAs that target USP43

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP43 Gene

Localization for USP43 Gene

Subcellular locations from

Jensen Localization Image for USP43 Gene COMPARTMENTS Subcellular localization image for USP43 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP43 Gene

Pathways & Interactions for USP43 Gene

genes like me logo Genes that share pathways with USP43: view

Gene Ontology (GO) - Biological Process for USP43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IEA --
genes like me logo Genes that share ontologies with USP43: view

No data available for SIGNOR curated interactions for USP43 Gene

Drugs & Compounds for USP43 Gene

No Compound Related Data Available

Transcripts for USP43 Gene

Unigene Clusters for USP43 Gene

Ubiquitin specific peptidase 43:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP43 Gene

No ASD Table

Relevant External Links for USP43 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP43 Gene

mRNA expression in normal human tissues for USP43 Gene

Protein differential expression in normal tissues from HIPED for USP43 Gene

This gene is overexpressed in Placenta (35.9) and Bone (32.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP43 Gene

SOURCE GeneReport for Unigene cluster for USP43 Gene Hs.709621

mRNA Expression by UniProt/SwissProt for USP43 Gene

Tissue specificity: Expressed in brain, aorta and lung at low levels.
genes like me logo Genes that share expression patterns with USP43: view

Protein tissue co-expression partners for USP43 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for USP43 Gene

Orthologs for USP43 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP43 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia USP43 35
  • 82.29 (n)
  • 80.85 (a)
USP43 36
  • 80 (a)
(Canis familiaris)
Mammalia USP43 35
  • 83.07 (n)
  • 79.24 (a)
USP43 36
  • 76 (a)
(Mus musculus)
Mammalia Usp43 35
  • 82.61 (n)
  • 82.15 (a)
Usp43 16
Usp43 36
  • 80 (a)
(Pan troglodytes)
Mammalia USP43 35
  • 99.58 (n)
  • 99.55 (a)
USP43 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Usp43 35
  • 81.88 (n)
  • 80.49 (a)
(Monodelphis domestica)
Mammalia USP43 36
  • 63 (a)
(Gallus gallus)
Aves USP43 36
  • 64 (a)
(Anolis carolinensis)
Reptilia USP43 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia usp43 35
  • 60.77 (n)
  • 55.1 (a)
(Danio rerio)
Actinopterygii LOC100149276 35
  • 63.18 (n)
  • 62.83 (a)
usp43a 36
  • 46 (a)
usp43b 36
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30421 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for USP43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP43 Gene

Gene Tree for USP43 (if available)
Gene Tree for USP43 (if available)

Paralogs for USP43 Gene

Paralogs for USP43 Gene

(1) SIMAP similar genes for USP43 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with USP43: view

Variants for USP43 Gene

Sequence variations from dbSNP and Humsavar for USP43 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs169289 -- 9,668,524(-) ACCAG(G/T)GGAAA intron-variant
rs175629 -- 9,647,579(+) ttaTT(C/T)TATCA intron-variant
rs427096 -- 9,711,673(-) CGAGC(A/G)GATCA intron-variant
rs429068 -- 9,658,226(-) GGCTC(C/T)GAGCA intron-variant
rs430881 -- 9,694,808(+) TAGTA(G/T)AGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP43 Gene

Variant ID Type Subtype PubMed ID
nsv7289 OTHER Inversion 18451855
nsv833357 CNV Loss 17160897
nsv833358 CNV Gain 17160897
nsv510697 CNV Loss 20534489

Variation tolerance for USP43 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for USP43 Gene

Disorders for USP43 Gene

Relevant External Links for USP43

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for USP43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP43 Gene

Publications for USP43 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for USP43 Gene

Sources for USP43 Gene