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Aliases for USP42 Gene

Aliases for USP42 Gene

  • Ubiquitin Specific Peptidase 42 2 3 5
  • Ubiquitin-Specific-Processing Protease 42 4
  • Ubiquitin Specific Protease 42 2
  • Deubiquitinating Enzyme 42 4
  • Ubiquitin Thioesterase 42 4
  • EC 3.4.19.12 4
  • EC 3.1.2.15 61

External Ids for USP42 Gene

Previous GeneCards Identifiers for USP42 Gene

  • GC07P005854
  • GC07P005895
  • GC07P005893
  • GC07P006111
  • GC07P006144
  • GC07P006022
  • GC07P006088

Summaries for USP42 Gene

GeneCards Summary for USP42 Gene

USP42 (Ubiquitin Specific Peptidase 42) is a Protein Coding gene. Diseases associated with USP42 include Leukemia, Acute Myeloid. Among its related pathways are Metabolism of proteins and Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP36.

UniProtKB/Swiss-Prot for USP42 Gene

  • Deubiquitinating enzyme which may play an important role during spermatogenesis.

Gene Wiki entry for USP42 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP42 Gene

Genomics for USP42 Gene

Regulatory Elements for USP42 Gene

Enhancers for USP42 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F005496 1.2 Ensembl ENCODE 29.9 -581.2 -581234 1.1 HDAC1 SCRT2 ZNF202 ZNF680 ZNF654 ZBTB2 ZBTB11 REST ZNF623 ZNF781 USP42 ANKRD61 RNF216P1 MIR589 FBXL18
GH07F005551 1.6 FANTOM5 ENCODE 19.7 -523.0 -522967 7.6 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC USP42 RPL22P16 AP5Z1 ANKRD61 ZNF890P EIF2AK1 CCZ1 ACTB WIPI2 ENSG00000272719
GH07F005995 1.2 Ensembl ENCODE 21.9 -83.0 -82959 1.5 PKNOX1 SIN3A FEZF1 GTF3C2 KLF7 FOS SP3 ZHX2 TSHZ1 ZNF518A ANKRD61 ZNF316 C7orf26 USP42 EIF2AK1 KDELR2 PMS2CL PMS2 RSPH10B CCZ1
GH07F006380 1.6 FANTOM5 Ensembl ENCODE 12.1 +306.0 306022 8.7 HDGF ATF1 ARID4B SIN3A FEZF1 SLC30A9 ZNF121 FOS ZNF263 ZHX2 DAGLB ANKRD61 ZNF316 C7orf26 KDELR2 FAM220A USP42 RAC1 CCZ1 ZDHHC4
GH07F006254 1.4 FANTOM5 Ensembl ENCODE 13.6 +180.2 180158 9.0 TBP PKNOX1 TBL1XR1 BMI1 RAD21 ZBTB40 RFX5 CBX5 ZNF143 ETV6 ENSG00000198580 ENSG00000228010 USP42 ZNF316 C7orf26 PMS2CL EIF2AK1 FAM220A CCZ1 GC07M006227
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around USP42 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP42 Gene

Chromosome:
7
Start:
6,078,743 bp from pter
End:
6,161,564 bp from pter
Size:
82,822 bases
Orientation:
Plus strand

Genomic View for USP42 Gene

Genes around USP42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP42 Gene

Proteins for USP42 Gene

  • Protein details for USP42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9J4-UBP42_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 42
    Protein Accession:
    Q9H9J4
    Secondary Accessions:
    • A2RUE3
    • B5MDA5
    • Q0VIN8
    • Q3C166
    • Q6P9B4

    Protein attributes for USP42 Gene

    Size:
    1324 amino acids
    Molecular mass:
    145392 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for USP42 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP42 Gene

Selected DME Specific Peptides for USP42 Gene

Q9H9J4:
  • SDTFDPYLDI
  • VYVLYAVLVH
  • QCLTYTPPLANY
  • SVLSQQAYVLFYI
  • FIGPQLP
  • CTMQAHIT
  • NLGNTCF

Post-translational modifications for USP42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for USP42 Gene

Gene Families for USP42 Gene

Protein Domains for USP42 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H9J4

UniProtKB/Swiss-Prot:

UBP42_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP42: view

Function for USP42 Gene

Molecular function for USP42 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme which may play an important role during spermatogenesis.

Enzyme Numbers (IUBMB) for USP42 Gene

Gene Ontology (GO) - Molecular Function for USP42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 14715245
GO:0005515 protein binding IPI 22085928
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP42: view
genes like me logo Genes that share phenotypes with USP42: view

Animal Models for USP42 Gene

MGI Knock Outs for USP42:

Animal Model Products

  • Taconic Biosciences Mouse Models for USP42

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP42 Gene

Localization for USP42 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP42 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP42 Gene

Pathways & Interactions for USP42 Gene

genes like me logo Genes that share pathways with USP42: view

Pathways by source for USP42 Gene

Gene Ontology (GO) - Biological Process for USP42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007283 spermatogenesis IEA --
GO:0016579 protein deubiquitination IEA,ISS --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with USP42: view

No data available for SIGNOR curated interactions for USP42 Gene

Drugs & Compounds for USP42 Gene

(1) Drugs for USP42 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with USP42: view

Transcripts for USP42 Gene

Unigene Clusters for USP42 Gene

Ubiquitin specific peptidase 42:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP42 Gene

No ASD Table

Relevant External Links for USP42 Gene

GeneLoc Exon Structure for
USP42
ECgene alternative splicing isoforms for
USP42

Expression for USP42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USP42 Gene

Protein differential expression in normal tissues from HIPED for USP42 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (65.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for USP42 Gene



Protein tissue co-expression partners for USP42 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of USP42 Gene:

USP42

SOURCE GeneReport for Unigene cluster for USP42 Gene:

Hs.31856

mRNA Expression by UniProt/SwissProt for USP42 Gene:

Q9H9J4-UBP42_HUMAN
Tissue specificity: Broadly expressed.
genes like me logo Genes that share expression patterns with USP42: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for USP42 Gene

Orthologs for USP42 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP42 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP42 34 35
  • 99.19 (n)
dog
(Canis familiaris)
Mammalia USP42 34 35
  • 81.45 (n)
cow
(Bos Taurus)
Mammalia USP42 34 35
  • 78.95 (n)
mouse
(Mus musculus)
Mammalia Usp42 34 16 35
  • 74.96 (n)
rat
(Rattus norvegicus)
Mammalia Usp42 34
  • 74.51 (n)
oppossum
(Monodelphis domestica)
Mammalia USP42 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP42 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP42 34
  • 56.23 (n)
lizard
(Anolis carolinensis)
Reptilia USP42 35
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii usp42 35
  • 39 (a)
OneToMany
wufi15g04 34
fruit fly
(Drosophila melanogaster)
Insecta scny 35
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 35
  • 23 (a)
OneToMany
Species where no ortholog for USP42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP42 Gene

ENSEMBL:
Gene Tree for USP42 (if available)
TreeFam:
Gene Tree for USP42 (if available)

Paralogs for USP42 Gene

genes like me logo Genes that share paralogs with USP42: view

Variants for USP42 Gene

Sequence variations from dbSNP and Humsavar for USP42 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10046499 -- 6,140,433(+) TCTTC(A/G)TATTA intron-variant
rs10216107 -- 6,141,049(+) TAGTT(C/T)ATTTA intron-variant
rs10225119 -- 6,145,563(+) TCTCA(A/G)CCCAA reference, synonymous-codon
rs10226743 -- 6,137,156(+) ACTGG(G/T)TAATT intron-variant
rs10228389 -- 6,132,532(+) ttttg(G/T)atttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP42 Gene

Variant ID Type Subtype PubMed ID
nsv950802 CNV deletion 24416366
nsv818475 CNV loss 17921354
nsv7392 OTHER inversion 18451855
nsv5628 CNV deletion 18451855
nsv522155 CNV loss 19592680
nsv510065 OTHER sequence alteration 20534489
nsv436904 CNV insertion 17901297
nsv1034916 CNV gain 25217958
esv3612018 CNV loss 21293372
esv2672123 CNV deletion 23128226
esv22984 CNV loss 19812545
esv1914954 OTHER inversion 16254605
dgv403n21 CNV loss 19592680
dgv3484n106 CNV deletion 24896259
dgv1183e199 CNV deletion 23128226

Variation tolerance for USP42 Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.06; 92.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP42 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP42 Gene

Disorders for USP42 Gene

MalaCards: The human disease database

(1) MalaCards diseases for USP42 Gene - From: DISEASES

Disorder Aliases PubMed IDs
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards
Search USP42 in MalaCards View complete list of genes associated with diseases

Relevant External Links for USP42

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP42
genes like me logo Genes that share disorders with USP42: view

No data available for UniProtKB/Swiss-Prot and Genatlas for USP42 Gene

Publications for USP42 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 64

Products for USP42 Gene

Sources for USP42 Gene

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