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USP42 Gene

protein-coding   GIFtS: 52
GCID: GC07P006144

Ubiquitin Specific Peptidase 42

(Previous name: ubiquitin specific protease 42)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 421 2     Ubiquitin Carboxyl-Terminal Hydrolase 422
Ubiquitin Specific Protease 421 2     Ubiquitin Thiolesterase 422
Deubiquitinating Enzyme 422 3     EC 3.4.19.123
Ubiquitin Thioesterase 422 3     EC 3.1.2.158
Ubiquitin-Specific-Processing Protease 422 3     

External Ids:    HGNC: 200681   Entrez Gene: 841322   Ensembl: ENSG000001063467   UniProtKB: Q9H9J43   

Export aliases for USP42 gene to outside databases

Previous GC identifers: GC07P005854 GC07P005895 GC07P005893 GC07P006111 GC07P006022


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for USP42 Gene:
USP42 (ubiquitin specific peptidase 42) is a protein-coding gene. Diseases associated with USP42 include myelodysplastic syndromes. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP17L13.

UniProtKB/Swiss-Prot: UBP42_HUMAN, Q9H9J4
Function: Deubiquitinating enzyme which may play an important role during spermatogenesis (By similarity)

Gene Wiki entry for USP42 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP42 gene promoter:
         Nkx3-1   Nkx3-1 v4   FOXF2   Pax-5   Nkx3-1 v1   Egr-2   Nkx3-1 v2   Nkx3-1 v3   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP42 promoter sequence
   Search Chromatin IP Primers for USP42

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP42


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.2

USP42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP42 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P006144:  view genomic region     (about GC identifiers)

Start:
6,144,515 bp from pter      End:
6,201,195 bp from pter
Size:
56,681 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 6,190,906-6,247,551     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UBP42_HUMAN, Q9H9J4 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 42  
Size: 1324 amino acids; 145392 Da
Secondary accessions: A2RUE3 B5MDA5 Q0VIN8 Q3C166 Q6P9B4
Alternative splicing: 2 isoforms:  Q9H9J4-1   Q9H9J4-2   

Explore the universe of human proteins at neXtProt for USP42: NX_Q9H9J4

Explore proteomics data for USP42 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for USP42 (Q9H9J4) (see all 7)
     NLGNTCF  FIGPQLP  CTMQAHIT  VYVLYAVLVH 


    See USP42 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115548.1  
    ENSEMBL proteins: 
     ENSP00000301962   ENSP00000385964   ENSP00000416910   ENSP00000430568   ENSP00000431127  
     ENSP00000408217  

    USP42 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for USP42
    GenScript Custom Purified and Recombinant Proteins Services for USP42
    Novus Biologicals USP42 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP42

    USP42 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for USP42
    OriGene Custom Antibody Services for USP42
    Novus Biologicals USP42 Antibodies
    Abcam antibodies for USP42
    Cloud-Clone Corp. Antibodies for USP42
    Search ThermoFisher Antibodies for USP42
    LSBio Antibodies in human, mouse, rat for USP42

    USP42 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP42
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP42
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP42
    Cloud-Clone Corp. CLIAs for USP42


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    3 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028889 UCH/PAN2

    Graphical View of Domain Structure for InterPro Entry Q9H9J4

    ProtoNet protein and cluster: Q9H9J4

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP42_HUMAN, Q9H9J4
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 USP domain


    USP42 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP42_HUMAN, Q9H9J4
    Function: Deubiquitinating enzyme which may play an important role during spermatogenesis (By similarity)
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity ----
    GO:0004843ubiquitin-specific protease activity IDA14715245
    GO:0005515protein binding IPI--
         
    USP42 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for USP42:
     Decreased influenza A/WSN/33 r 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Usp42):
     behavior/neurological  hematopoietic system  immune system  reproductive system  vision/eye 

    USP42 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP42
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP42

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP42
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP42

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP42:
    hsa-mir-320a (MIRT044815), hsa-mir-103a-3p (MIRT027058), hsa-mir-16-5p (MIRT031569)

    Block miRNA regulation of human, mouse, rat USP42 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP42 (see all 59):
    hsa-miR-194* hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-128 hsa-miR-29a hsa-miR-16-1*
    SwitchGear 3'UTR luciferase reporter plasmidUSP42 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP42
    Predesigned siRNA for gene silencing in human, mouse, rat USP42

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP42

    Clone
    Products:
         
    OriGene clones in human, mouse for USP42 (see all 7)
    OriGene ORF clones in mouse, rat for USP42
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP42 (NM_032172)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP42

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for USP42
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP42 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP42


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP42 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP42
        Ubiquitin-Proteasome Dependent Proteolysis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP42
    Interactions:

        Search GeneGlobe Interaction Network for USP42

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP42 (Q9H9J41, 2, 3 ENSP000003019624) via UniProtKB, MINT, STRING, and/or I2D (see all 131)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046371, 2, 3, ENSP000002693054EBI-7544475,EBI-366083 MINT-8303846 MINT-8303829 I2D: score=1 STRING: ENSP00000269305
    YWHAQP273482, 3, ENSP000002380814MINT-7899812 I2D: score=1 STRING: ENSP00000238081
    CA2P009183, ENSP000002853794I2D: score=2 STRING: ENSP00000285379
    HERC2O957143, ENSP000002616094I2D: score=2 STRING: ENSP00000261609
    LRRC47Q8N1G43, ENSP000003674984I2D: score=2 STRING: ENSP00000367498
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0007283spermatogenesis IEA--
    GO:0016579protein deubiquitination ISS--
    GO:0030154cell differentiation IEA--

    USP42 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP42 (UBP42)

    1 HMDB Compound for USP42    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for USP42 gene: 
    NM_032172.2  

    Unigene Cluster for USP42:

    Ubiquitin specific peptidase 42
    Hs.31856  [show with all ESTs]
    Unigene Representative Sequence: NM_032172
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306177(uc010kth.1 uc011jwp.2) ENST00000404008(uc011jwn.1)
    ENST00000479544(uc011jwo.1) ENST00000451154 ENST00000465073 ENST00000521713(uc011jwq.2)
    ENST00000426246(uc011jwr.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP42 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP42 (see all 59):
    hsa-miR-194* hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-128 hsa-miR-29a hsa-miR-16-1*
    SwitchGear 3'UTR luciferase reporter plasmidUSP42 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for USP42
    Predesigned siRNA for gene silencing in human, mouse, rat USP42
    Clone
    Products:
         
    OriGene clones in human, mouse for USP42 (see all 7)
    OriGene ORF clones in mouse, rat for USP42
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP42 (NM_032172)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP42
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for USP42
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP42
      QuantiTect SYBR Green Assays in human, mouse, rat USP42
      QuantiFast Probe-based Assays in human, mouse, rat USP42

    Additional mRNA sequence: 

    AJ601395.1 AK022759.1 AK298164.1 AK301527.1 AK309375.1 AY618868.1 BC060846.1 BC132862.1 
    BC136656.1 

    12 DOTS entries:

    DT.100784607  DT.87018386  DT.453542  DT.121099480  DT.100035427  DT.100784609  DT.101959112  DT.121099479 
    DT.121099499  DT.40239023  DT.102829219  DT.99950401 

    Selected AceView cDNA sequences (see all 211):

    AI015760 BC060846 BU173371 BF939353 AI202031 AA251636 AW008788 BF195598 
    AI817983 AI190219 AA633793 AW298129 BF725643 AI498107 AI738779 AK022759 
    AI936218 AA782139 AW594202 AW004062 BU187025 BU195574 AW270967 AU130866 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP42 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAATTTCT
    USP42 Expression
    About this image

    USP42 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP42 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.31856

    UniProtKB/Swiss-Prot: UBP42_HUMAN, Q9H9J4
    Tissue specificity: Broadly expressed

        Custom PCR Arrays for USP42
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP42
    QuantiTect SYBR Green Assays in human, mouse, rat USP42
    QuantiFast Probe-based Assays in human, mouse, rat USP42
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP42

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP42 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp421 , 5 ubiquitin specific peptidase 421, 5 74.96(n)1
    71.42(a)1
      5 (82.50 cM)5
    768001  NM_029749.21  NP_084025.21 
     1437103255 
    chicken
    (Gallus gallus)
    Aves USP421 ubiquitin specific peptidase 42 56.23(n)
    47.91(a)
      416431  XM_414742.4  XP_414742.3 
    lizard
    (Anolis carolinensis)
    Reptilia USP426
    ubiquitin specific peptidase 42
    52(a)
    1 ↔ 1
    GL343507.1(179242-198091)
    zebrafish
    (Danio rerio)
    Actinopterygii wufi15g042 Danio rerio, Similar to KIAA1453 protein, clone IMAGE26 more 79.09(n)    BC057482.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta scny6
    scrawny
    21(a)
    1 → many
    3L(5762223-5769371)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP86
    Ubiquitin-specific protease that is a component of...
    23(a)
    1 → many
    XIII(716715-718130) YMR223W


    ENSEMBL Gene Tree for USP42 (if available)
    TreeFam Gene Tree for USP42 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP42 gene
    USP17L132  USP17L282  USP17L242  USP222  USP17L302  USP17L122  USP17L172  USP17L232  
    USP17L262  USP17L182  USP512  USP17L252  USP17L152  USP17L202  USP17L192  USP17L212  
    USP17L102  USP17L272  USP362  USP27X2  USP17L222  USP17L22  USP17L292  USP17L52  
    USP17L112  
    Selected SIMAP similar genes for USP42 using alignment to 8 protein entries:     UBP42_HUMAN (see all proteins) (see all similar genes):
    USP17L6P    DUB1    USP17L3    USP17L1P    USP17L24    USP17L25
    USP17L26    USP17L27    USP17L28    USP17L29    USP17L30    USP17L5
    USP17L4    USP17L7    USP17L11    USP17L2    USP17L8    USP17L12

    USP42 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP42 (see all 1512)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1482160241,2
    --6142595(+) GGTCAA/GGACAG 1 -- us2k10--------
    rs1140865941,2
    C,F--6142691(+) GTCTGG/ATGAGC 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs283735551,2
    C--6142729(+) AGGGAG/AAAGCA 1 -- us2k14Minor allele frequency- A:0.14NA WA 124
    rs796076701,2
    C,F--6142878(+) TGCTAG/AGATTT 1 -- us2k11Minor allele frequency- A:0.04NA 120
    rs1173308631,2
    F--6142899(+) CTGGAC/TGGGGT 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs1179494061,2
    F--6142913(+) CAGGGG/ATCTAT 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1809924061,2
    --6142996(+) AACTCC/TGTCTC 1 -- us2k10--------
    rs1148631861,2
    F--6143002(+) GTCTCT/CACAAA 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1858700951,2
    --6143024(+) TAGCCA/GGGCGT 1 -- us2k10--------
    rs1402433201,2
    C--6143042(+) GGCATC/GTGTAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for USP42 (6144515 - 6201195 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for USP42 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1183e199CNV Deletion23128226
    esv2672123CNV Deletion23128226
    nsv436904CNV Insertion17901297
    nsv5628CNV Loss18451855
    dgv403n21CNV Loss19592680
    nsv510065CNV Loss20534489
    dgv7146n71CNV Loss21882294
    esv22984CNV Loss19812545
    nsv818475CNV Loss17921354
    nsv522155CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP42
    DNA2.0 Custom Variant and Variant Library Synthesis for USP42

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for USP42:    
    About MalaCards
    myelodysplastic syndromes


    USP42 for disorders           About GeneDecksing


    Export disorders for USP42 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP42 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with USP42)
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    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004)
    5. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    6. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (Eur. J. Neurosci. 2012)
    7. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)
    8. Regulation of p53 stability and function by the deubiquitinating enzyme USP42. (PubMed id 22085928)1 Hock A.K....Vousden K.H. (EMBO J. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84132 HGNC: 20068 AceView: USP42 Ensembl:ENSG00000106346 euGenes: HUgn84132
    ECgene: USP42 H-InvDB: USP42

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP42 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP42 gene:
    Search GeneIP for patents involving USP42

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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