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Aliases for USP42 Gene

Aliases for USP42 Gene

  • Ubiquitin Specific Peptidase 42 2 3
  • Ubiquitin-Specific-Processing Protease 42 4
  • Ubiquitin Specific Protease 42 2
  • Deubiquitinating Enzyme 42 4
  • Ubiquitin Thioesterase 42 4
  • EC 4
  • EC 63

External Ids for USP42 Gene

Previous GeneCards Identifiers for USP42 Gene

  • GC07P005854
  • GC07P005895
  • GC07P005893
  • GC07P006111
  • GC07P006144
  • GC07P006022
  • GC07P006088

Summaries for USP42 Gene

GeneCards Summary for USP42 Gene

USP42 (Ubiquitin Specific Peptidase 42) is a Protein Coding gene. Diseases associated with USP42 include leukemia, acute myeloid. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include cysteine-type endopeptidase activity and ubiquitinyl hydrolase activity. An important paralog of this gene is USP36.

UniProtKB/Swiss-Prot for USP42 Gene

  • Deubiquitinating enzyme which may play an important role during spermatogenesis.

Gene Wiki entry for USP42 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP42 Gene

Genomics for USP42 Gene

Regulatory Elements for USP42 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for USP42 Gene

6,078,743 bp from pter
6,161,564 bp from pter
82,822 bases
Plus strand

Genomic View for USP42 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP42 Gene

Proteins for USP42 Gene

  • Protein details for USP42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 42
    Protein Accession:
    Secondary Accessions:
    • A2RUE3
    • B5MDA5
    • Q0VIN8
    • Q3C166
    • Q6P9B4

    Protein attributes for USP42 Gene

    1324 amino acids
    Molecular mass:
    145392 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for USP42 Gene


neXtProt entry for USP42 Gene

Proteomics data for USP42 Gene at MOPED

Selected DME Specific Peptides for USP42 Gene

Post-translational modifications for USP42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP42 Gene

Antibody Products

Domains & Families for USP42 Gene

Gene Families for USP42 Gene

Protein Domains for USP42 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP42: view

Function for USP42 Gene

Molecular function for USP42 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme which may play an important role during spermatogenesis.

Enzyme Numbers (IUBMB) for USP42 Gene

Gene Ontology (GO) - Molecular Function for USP42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0004843 ubiquitin-specific protease activity IDA 14715245
GO:0005515 protein binding IPI 22085928
GO:0036459 ubiquitinyl hydrolase activity --
genes like me logo Genes that share ontologies with USP42: view
genes like me logo Genes that share phenotypes with USP42: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP42

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for USP42 Gene

Localization for USP42 Gene

Subcellular locations from

Jensen Localization Image for USP42 Gene COMPARTMENTS Subcellular localization image for USP42 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP42 Gene

Pathways & Interactions for USP42 Gene

genes like me logo Genes that share pathways with USP42: view

Pathways by source for USP42 Gene

1 Qiagen pathway for USP42 Gene

Gene Ontology (GO) - Biological Process for USP42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0007283 spermatogenesis IEA --
GO:0016579 protein deubiquitination ISS --
GO:0030154 cell differentiation IEA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with USP42: view

No data available for SIGNOR curated interactions for USP42 Gene

Drugs & Compounds for USP42 Gene

(1) Additional Compounds for USP42 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with USP42: view

Transcripts for USP42 Gene

Unigene Clusters for USP42 Gene

Ubiquitin specific peptidase 42:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP42

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP42 Gene

No ASD Table

Relevant External Links for USP42 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP42 Gene

mRNA expression in normal human tissues for USP42 Gene

Protein differential expression in normal tissues from HIPED for USP42 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (65.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP42 Gene

SOURCE GeneReport for Unigene cluster for USP42 Gene Hs.31856

mRNA Expression by UniProt/SwissProt for USP42 Gene

Tissue specificity: Broadly expressed.
genes like me logo Genes that share expression patterns with USP42: view

Protein tissue co-expression partners for USP42 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for USP42 Gene

Orthologs for USP42 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP42 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia USP42 35
  • 78.95 (n)
  • 74.31 (a)
USP42 36
  • 73 (a)
(Canis familiaris)
Mammalia USP42 35
  • 81.45 (n)
  • 78.55 (a)
USP42 36
  • 77 (a)
(Mus musculus)
Mammalia Usp42 35
  • 74.96 (n)
  • 71.42 (a)
Usp42 16
Usp42 36
  • 69 (a)
(Pan troglodytes)
Mammalia USP42 35
  • 99.19 (n)
  • 98.71 (a)
USP42 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Usp42 35
  • 74.51 (n)
  • 72.24 (a)
(Monodelphis domestica)
Mammalia USP42 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia USP42 36
  • 58 (a)
(Gallus gallus)
Aves USP42 35
  • 56.23 (n)
  • 47.91 (a)
(Anolis carolinensis)
Reptilia USP42 36
  • 52 (a)
(Danio rerio)
Actinopterygii wufi15g04 35
usp42 36
  • 39 (a)
fruit fly
(Drosophila melanogaster)
Insecta scny 36
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 36
  • 23 (a)
Species with no ortholog for USP42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP42 Gene

Gene Tree for USP42 (if available)
Gene Tree for USP42 (if available)

Paralogs for USP42 Gene

genes like me logo Genes that share paralogs with USP42: view

Variants for USP42 Gene

Sequence variations from dbSNP and Humsavar for USP42 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs472137 -- 6,087,621(-) GGGAG(A/C)TAATT intron-variant
rs520044 -- 6,146,450(-) actcc(C/T)gggct intron-variant
rs538319 -- 6,091,604(-) TGGGG(G/T)TGAGA intron-variant
rs539130 -- 6,091,538(-) TAGAC(A/G)CTATG intron-variant
rs540930 -- 6,091,342(-) GAGGC(G/T)GAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP42 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv7392 OTHER Inversion 18451855
esv1914954 OTHER Inversion 16254605
nsv5628 CNV Loss 18451855
dgv1183e199 CNV Deletion 23128226
esv22984 CNV Loss 19812545
nsv510065 CNV Loss 20534489
nsv522155 CNV Loss 19592680
dgv403n21 CNV Loss 19592680
nsv818475 CNV Loss 17921354
dgv7146n71 CNV Loss 21882294
esv2672123 CNV Deletion 23128226

Variation tolerance for USP42 Gene

Residual Variation Intolerance Score: 61.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.06; 92.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP42 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP42 Gene

Disorders for USP42 Gene

MalaCards: The human disease database

(1) MalaCards diseases for USP42 Gene - From: DISEASES

Disorder Aliases PubMed IDs
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association
Search USP42 in MalaCards View complete list of genes associated with diseases

Relevant External Links for USP42

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with USP42: view

No data available for UniProtKB/Swiss-Prot and Genatlas for USP42 Gene

Publications for USP42 Gene

  1. Molecular characterisation of a recurrent, semi-cryptic RUNX1 translocation t(7;21) in myelodysplastic syndrome and acute myeloid leukaemia. (PMID: 20064152) Foster N. … Tauro S. (Br. J. Haematol. 2010) 23 67
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 67
  3. Whole transcriptome sequencing of a paediatric case of de novo acute myeloid leukaemia with del(5q) reveals RUNX1-USP42 and PRDM16-SKI fusion transcripts. (PMID: 24673627) Masetti R. … Locatelli F. (Br. J. Haematol. 2014) 67
  4. Ubiquitin-specific peptidase 42 (USP42) functions to deubiquitylate histones and regulate transcriptional activity. (PMID: 25336640) Hock A.K. … Vousden K.H. (J. Biol. Chem. 2014) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for USP42 Gene

Sources for USP42 Gene

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