USP41 Gene
protein-coding GIFtS: 33
GCID: GC22M020704 (predicted)
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ubiquitin specific peptidase 41(Previous name: ubiquitin specific protease 41 )
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Aliases
for USP41 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 411 2 | | Putative Ubiquitin Carboxyl-Terminal Hydrolase 412 | | Ubiquitin Specific Protease 411 2 | | Ubiquitin Specific Proteinase 412 | | Deubiquitinating Enzyme 412 3 | | Ubiquitin Thiolesterase 412 | | Ubiquitin Thioesterase 412 3 | | EC 3.4.19.123 | | Ubiquitin-Specific-Processing Protease 412 3 | | EC 3.1.2.158 |
Export aliases for USP41 gene to outside databasesPrevious GC identifers: GC00U909401 GC22U900095 GC22M018726 GC22M019022 GC22M003968 |
Summaries
for USP41 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UBP41_HUMAN, Q3LFD5Function: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processingof poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity)
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Genomic Views
for USP41 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP41 gene promoter:
Spz1 COMP1 YY1 C/EBPalpha Roaz
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP41
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP41 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.22USP41 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M020704: view genomic region
(about GC identifiers)
Start:
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20,704,868 bp from pter |
End:
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20,745,048 bp from pter |
Size:
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40,181 bases |
Orientation:
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minus strand |
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Proteins
for USP41 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP41_HUMAN, Q3LFD5 (See
protein sequence)Recommended Name: Putative ubiquitin carboxyl-terminal hydrolase 41 Size: 358 amino acids; 41394 Da
Secondary accessions: A8MXD0 Q70BM7Explore the universe of human proteins at neXtProt for USP41: NX_Q3LFD5
3 DME Specific Peptides for USP41 (Q3LFD5)
USP41 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000292729 ENSP00000414922
Human Recombinant Protein Products:
USP41 Antibody Products:
Assay Products for USP41: |
Protein
Domains /
Families
for USP41 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP41 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q3LFD5ProtoNet protein and cluster: Q3LFD5 1 Blocks protein family: IPB001394 Ubiquitin thiolesterase
UniProtKB/Swiss-Prot: UBP41_HUMAN, Q3LFD5Similarity: Belongs to the peptidase C19 family |
Function
for USP41 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: UBP41_HUMAN, Q3LFD5Function: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processingof poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity)Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP41 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0004221 | ubiquitin thiolesterase activity |
IEA | -- | | GO:0008234 | cysteine-type peptidase activity |
IEA | -- |
USP41 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for USP41:
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Pathways & Interactions
for USP41 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Ubiquitin-Proteasome Dependent Proteolysis | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP41
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP41
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for USP41 (Q3LFD53 ENSP000004149224) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- |
USP41 for ontologies About GeneDecksing
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Drugs & Compounds
for USP41 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USP41
Search CenterWatch for drugs/clinical trials and news about USP41 / UBP41
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Transcripts
for USP41 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000486536(uc011ahp.1) ENST00000292729 ENST00000470202 ENST00000454608(uc011ahq.1)
8 AceView cDNA sequences: BF089771 AJ586979 BG391572 BG390407 H55154 BF062298 AA303390 BQ359633
GeneLoc Exon Structure
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Expression
for USP41 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP41 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See USP41 Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for USP41
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat USP41 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP41 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP41 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP41 |
Orthologs
for USP41 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for USP41 gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
E1BXQ0_CHICK6 |
Ubiquitin carboxyl-terminal hydrolase |
44(a) |
1 → many |
1(64220835-64234791) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
50(a) |
1 → many |
5(14365848-14374457) |
zebrafish
(Danio rerio) |
Actinopterygii |
CU571169.46 |
-- |
23(a) |
1 → many |
4(5715803-5720646) |
worm
(Caenorhabditis elegans) |
Secernentea |
usp-486 |
-- |
5(a) |
possible ortholog |
I(9506545-9511177) |
ENSEMBL Gene Tree for USP41 (if available)
TreeFam Gene Tree for USP41 (if available) |
Paralogs
for USP41 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP41 gene
- USP242 USP182 USP482 USP402 USP72 USP472 USP9Y2 USP342
- USP9X2
3 SIMAP similar genes for USP41 using alignment to 2 protein entries: UBP41_HUMAN (see all proteins):USP18 USP15 Em
USP41 for paralogs About GeneDecksing
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Genomic Variants
for USP41 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP41 (20704868 - 20745048 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for USP41: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP41 |
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Disorders
/ Diseases
for USP41 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP41 for disorders About GeneDecksing
1  disease for USP41: About MalaCardsmalaria
Export disorders for USP41 gene to outside databases
|
Publications
for USP41 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USP41 gene integrated from 9 sources:
(articles sorted by number of sources associating them with USP41) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (2004)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)
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External Searches for USP41 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing USP41 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing USP41 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing USP41 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for USP41 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for USP41 gene:
Search GeneIP for patents involving USP41
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for USP41 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP41 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP41 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP41 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP41 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP41 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP41 |
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 |  |  |  | |
| | | | Search Tocris compounds for USP41 |
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 | | | USP41 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP41 |
|  |  |  | | | | Search ThermoFisher Antibodies for USP41 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat USP41 |
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