Free for academic non-profit institutions. Other users need a Commercial license

Aliases for USP41 Gene

Aliases for USP41 Gene

  • Ubiquitin Specific Peptidase 41 2 3
  • Ubiquitin-Specific-Processing Protease 41 4
  • Ubiquitin Specific Protease 41 2
  • Deubiquitinating Enzyme 41 4
  • Ubiquitin Thioesterase 41 4
  • EC 3.4.19.12 4
  • EC 3.1.2.15 64

External Ids for USP41 Gene

Summaries for USP41 Gene

GeneCards Summary for USP41 Gene

USP41 (Ubiquitin Specific Peptidase 41) is a Protein Coding gene. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include ubiquitin thiolesterase activity and cysteine-type peptidase activity. An important paralog of this gene is USP40.

UniProtKB/Swiss-Prot for USP41 Gene

  • May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP41 Gene

Genomics for USP41 Gene

Genomic Location for USP41 Gene

Start:
20,350,578 bp from pter
End:
20,390,758 bp from pter
Size:
40,181 bases
Orientation:
Minus strand

Genomic View for USP41 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP41 Gene

Regulatory Elements for USP41 Gene

Proteins for USP41 Gene

  • Protein details for USP41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LFD5-UBP41_HUMAN
    Recommended name:
    Putative ubiquitin carboxyl-terminal hydrolase 41
    Protein Accession:
    Q3LFD5
    Secondary Accessions:
    • A8MXD0
    • Q70BM7

    Protein attributes for USP41 Gene

    Size:
    358 amino acids
    Molecular mass:
    41394 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP41 Gene

Proteomics data for USP41 Gene at MOPED

Selected DME Specific Peptides for USP41 Gene

Post-translational modifications for USP41 Gene

No Post-translational modifications

Other Protein References for USP41 Gene

ENSEMBL proteins:
Reactome Protein details:

Domains for USP41 Gene

Gene Families for USP41 Gene

HGNC:
  • USP :Ubiquitin-specific peptidases

Protein Domains for USP41 Gene

UniProtKB/Swiss-Prot:

UBP41_HUMAN
Domain:
  • Contains 1 USP domain.:
    • Q3LFD5
Family:
  • Belongs to the peptidase C19 family.:
    • Q3LFD5
genes like me logo Genes that share domains with USP41: view

Function for USP41 Gene

Molecular function for USP41 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
UniProtKB/Swiss-Prot Function: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Enzyme Numbers (IUBMB) for USP41 Gene

Gene Ontology (GO) - Molecular Function for USP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0004843 ubiquitin-specific protease activity IBA --
GO:0008234 cysteine-type peptidase activity --
GO:0019785 ISG15-specific protease activity IBA --
GO:0036459 ubiquitinyl hydrolase activity --
genes like me logo Genes that share ontologies with USP41: view

Phenotypes for USP41 Gene

GenomeRNAi human phenotypes for USP41:
genes like me logo Genes that share phenotypes with USP41: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for USP41 Gene

Localization for USP41 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP41 Gene COMPARTMENTS Subcellular localization image for USP41 gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for USP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with USP41: view

Pathways for USP41 Gene

genes like me logo Genes that share pathways with USP41: view

Gene Ontology (GO) - Biological Process for USP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0016579 protein deubiquitination IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0061136 regulation of proteasomal protein catabolic process IBA --
genes like me logo Genes that share ontologies with USP41: view

Transcripts for USP41 Gene

mRNA/cDNA for USP41 Gene

(2) REFSEQ mRNAs :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for USP41 Gene

No ASD Table

Relevant External Links for USP41 Gene

GeneLoc Exon Structure for
USP41
ECgene alternative splicing isoforms for
USP41

Expression for USP41 Gene

mRNA expression in normal human tissues for USP41 Gene

genes like me logo Genes that share expressions with USP41: view

Orthologs for USP41 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP18 37
  • 83 (a)
OneToMany
cow
(Bos Taurus)
Mammalia USP18 37
  • 73 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 73 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Usp18 37
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 57 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 44 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 43 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU571169.4 37
  • 27 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Ubp64E 37
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T05H10.1 37
  • 6 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP15 37
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 7 (a)
OneToMany
Species with no ortholog for USP41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for USP41 Gene

ENSEMBL:
Gene Tree for USP41 (if available)
TreeFam:
Gene Tree for USP41 (if available)

Paralogs for USP41 Gene

Paralogs for USP41 Gene

Selected SIMAP similar genes for USP41 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with USP41: view

Variants for USP41 Gene

Sequence variations from dbSNP and Humsavar for USP41 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs361689 -- 20,388,160(+) CTTAA(A/C)TTCAC intron-variant
rs361764 -- 20,382,025(+) gtgtt(A/G)ctgca intron-variant
rs361766 -- 20,389,481(+) TGGGG(C/T)ATGAC intron-variant
rs361839 -- 20,369,562(-) ACTGC(-/GACTGC)AGGCC cds-indel
rs361885 -- 20,390,178(-) TGCCC(C/T)TTTTT intron-variant

Relevant External Links for USP41 Gene

HapMap Linkage Disequilibrium report
USP41

No data available for Structural Variations from Database of Genomic Variants (DGV) for USP41 Gene

Disorders for USP41 Gene

No disorders were found for USP41 Gene.

No data available for UniProtKB/Swiss-Prot for USP41 Gene

Publications for USP41 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 3 4
  3. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 4

Products for USP41 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate USP41
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for USP41
    • Block miRNA regulation of USP41 using miScript Target Protectors

    Sources for USP41 Gene

    Back to Top

    Content