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Aliases for USP41 Gene

Aliases for USP41 Gene

  • Ubiquitin Specific Peptidase 41 2 3 5
  • Ubiquitin-Specific-Processing Protease 41 4
  • Ubiquitin Specific Protease 41 2
  • Deubiquitinating Enzyme 41 4
  • Ubiquitin Thioesterase 41 4
  • EC 4
  • EC 61

External Ids for USP41 Gene

Previous GeneCards Identifiers for USP41 Gene

  • GC00U909401
  • GC22U900095
  • GC22M018726
  • GC22M019022
  • GC22M020704
  • GC22M003968

Summaries for USP41 Gene

GeneCards Summary for USP41 Gene

USP41 (Ubiquitin Specific Peptidase 41) is a Protein Coding gene. Among its related pathways are Interferon gamma signaling and Innate Immune System. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP18.

UniProtKB/Swiss-Prot for USP41 Gene

  • May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP41 Gene

Genomics for USP41 Gene

Regulatory Elements for USP41 Gene

Enhancers for USP41 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G020462 1 Ensembl ENCODE 11.4 -73.3 -73272 2.8 HDAC1 KLF1 TSC22D4 YBX1 ZNF384 RBBP5 RELA POLR2A KDM5B PRDM10 MED15 SCARF2 RNU6-225P KLHL22 ABHD17AP4 ZNF74 USP41 ENSG00000236003 LZTR1 PIR53917
GH22G020393 1.1 ENCODE 0.7 -3.3 -3317 1.5 HDGF PKNOX1 CREB3L1 ARNT AGO1 SIN3A DMAP1 ZNF2 YY1 ZNF766 RPL7AP70 ABHD17AP4 ZNF74 USP41
GH22G020371 0.5 Ensembl 0.4 +19.0 19040 0.7 HDGF SREBF1 KLF1 PIR42203 GC22P020363 GC22P020364 GC22P020366 GC22P020368 GC22P020369 GC22P020371 GC22P020372 GC22P020374 USP41
GH22G020364 0.5 Ensembl 0.3 +25.9 25932 0.9 CEBPB CEBPG ZNF507 DGCR6L GC22P020363 GC22P020364 GC22P020366 GC22P020368 GC22P020369 GC22P020371 GC22P020372 GC22P020374 PIR42203
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around USP41 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP41 Gene

20,350,578 bp from pter
20,390,758 bp from pter
40,181 bases
Minus strand

Genomic View for USP41 Gene

Genes around USP41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP41 Gene

Proteins for USP41 Gene

  • Protein details for USP41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative ubiquitin carboxyl-terminal hydrolase 41
    Protein Accession:
    Secondary Accessions:
    • A8MXD0
    • Q70BM7

    Protein attributes for USP41 Gene

    358 amino acids
    Molecular mass:
    41394 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP41 Gene

Selected DME Specific Peptides for USP41 Gene


Post-translational modifications for USP41 Gene

No Post-translational modifications

Other Protein References for USP41 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for USP41 Gene

Gene Families for USP41 Gene

Protein Domains for USP41 Gene

Suggested Antigen Peptide Sequences for USP41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C19 family.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP41: view

Function for USP41 Gene

Molecular function for USP41 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Enzyme Numbers (IUBMB) for USP41 Gene

Gene Ontology (GO) - Molecular Function for USP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP41: view
genes like me logo Genes that share phenotypes with USP41: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP41 Gene

Localization for USP41 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP41 gene
Compartment Confidence
extracellular 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP41 Gene

Pathways & Interactions for USP41 Gene

genes like me logo Genes that share pathways with USP41: view

Gene Ontology (GO) - Biological Process for USP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IEA --
genes like me logo Genes that share ontologies with USP41: view

No data available for SIGNOR curated interactions for USP41 Gene

Drugs & Compounds for USP41 Gene

No Compound Related Data Available

Transcripts for USP41 Gene

mRNA/cDNA for USP41 Gene

(2) REFSEQ mRNAs :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for USP41 Gene

No ASD Table

Relevant External Links for USP41 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP41 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP41 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP41 Gene:

genes like me logo Genes that share expression patterns with USP41: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP41 Gene

Orthologs for USP41 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP41 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia USP18 35
  • 83 (a)
(Bos Taurus)
Mammalia USP18 35
  • 73 (a)
(Canis familiaris)
Mammalia -- 35
  • 73 (a)
(Mus musculus)
Mammalia Usp18 35
  • 63 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 55 (a)
(Gallus gallus)
Aves -- 35
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 43 (a)
(Danio rerio)
Actinopterygii CU571169.4 35
  • 27 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ubp64E 35
  • 6 (a)
(Caenorhabditis elegans)
Secernentea T05H10.1 35
  • 6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP15 35
  • 6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 7 (a)
Species where no ortholog for USP41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for USP41 Gene

Gene Tree for USP41 (if available)
Gene Tree for USP41 (if available)

Paralogs for USP41 Gene

Paralogs for USP41 Gene

(3) SIMAP similar genes for USP41 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with USP41: view

Variants for USP41 Gene

Sequence variations from dbSNP and Humsavar for USP41 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000336410 -- 20,368,340(+) ATTTT(C/T)GGGCA intron-variant
rs1000394418 -- 20,374,553(+) AGTGA(-/G)AAGAG intron-variant
rs1000494462 -- 20,363,500(+) GAGTG(C/T)TGGAG downstream-variant-500B
rs1000631568 -- 20,363,357(+) GATGG(C/T)AAACG downstream-variant-500B
rs1000704507 -- 20,376,155(+) GGCAG(A/C)AAAGG intron-variant

Variation tolerance for USP41 Gene

Gene Damage Index Score: 10.54; 91.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP41 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for USP41 Gene

Disorders for USP41 Gene

Relevant External Links for USP41

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for USP41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP41 Gene

Publications for USP41 Gene

  1. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 3 4 64
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3 64
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 4 64

Products for USP41 Gene

Sources for USP41 Gene

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