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Aliases for USP41 Gene

Aliases for USP41 Gene

  • Ubiquitin Specific Peptidase 41 2 3 5
  • Ubiquitin-Specific-Processing Protease 41 4
  • Ubiquitin Specific Protease 41 2
  • Deubiquitinating Enzyme 41 4
  • Ubiquitin Thioesterase 41 4
  • EC 4
  • EC 63

External Ids for USP41 Gene

Previous GeneCards Identifiers for USP41 Gene

  • GC00U909401
  • GC22U900095
  • GC22M018726
  • GC22M019022
  • GC22M020704
  • GC22M003968

Summaries for USP41 Gene

GeneCards Summary for USP41 Gene

USP41 (Ubiquitin Specific Peptidase 41) is a Protein Coding gene. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP47.

UniProtKB/Swiss-Prot for USP41 Gene

  • May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP41 Gene

Genomics for USP41 Gene

Regulatory Elements for USP41 Gene

Genomic Location for USP41 Gene

20,350,578 bp from pter
20,390,758 bp from pter
40,181 bases
Minus strand

Genomic View for USP41 Gene

Genes around USP41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP41 Gene

Proteins for USP41 Gene

  • Protein details for USP41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative ubiquitin carboxyl-terminal hydrolase 41
    Protein Accession:
    Secondary Accessions:
    • A8MXD0
    • Q70BM7

    Protein attributes for USP41 Gene

    358 amino acids
    Molecular mass:
    41394 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP41 Gene

Proteomics data for USP41 Gene at MOPED

Selected DME Specific Peptides for USP41 Gene

Post-translational modifications for USP41 Gene

No Post-translational modifications

Other Protein References for USP41 Gene

ENSEMBL proteins:

Domains & Families for USP41 Gene

Gene Families for USP41 Gene

Protein Domains for USP41 Gene

Suggested Antigen Peptide Sequences for USP41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP41: view

Function for USP41 Gene

Molecular function for USP41 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Enzyme Numbers (IUBMB) for USP41 Gene

Gene Ontology (GO) - Molecular Function for USP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP41: view
genes like me logo Genes that share phenotypes with USP41: view

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for USP41 Gene

Localization for USP41 Gene

Subcellular locations from

Jensen Localization Image for USP41 Gene COMPARTMENTS Subcellular localization image for USP41 gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP41 Gene

Pathways & Interactions for USP41 Gene

genes like me logo Genes that share pathways with USP41: view

Gene Ontology (GO) - Biological Process for USP41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with USP41: view

No data available for SIGNOR curated interactions for USP41 Gene

Drugs & Compounds for USP41 Gene

No Compound Related Data Available

Expression for USP41 Gene

mRNA expression in normal human tissues for USP41 Gene

genes like me logo Genes that share expression patterns with USP41: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for USP41 Gene

Orthologs for USP41 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP41 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia USP18 36
  • 73 (a)
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
(Mus musculus)
Mammalia Usp18 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
(Pan troglodytes)
Mammalia USP18 36
  • 83 (a)
(Gallus gallus)
Aves -- 36
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
(Danio rerio)
Actinopterygii CU571169.4 36
  • 27 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ubp64E 36
  • 6 (a)
(Caenorhabditis elegans)
Secernentea T05H10.1 36
  • 6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP15 36
  • 6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 7 (a)
Species with no ortholog for USP41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for USP41 Gene

Gene Tree for USP41 (if available)
Gene Tree for USP41 (if available)

Paralogs for USP41 Gene

Paralogs for USP41 Gene

(3) SIMAP similar genes for USP41 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with USP41: view

Variants for USP41 Gene

Sequence variations from dbSNP and Humsavar for USP41 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2542134 - 20,375,501(+) CGTTG(C/T)ACTTC reference, missense
rs2277833 - 20,364,235(-) CCGGA(A/G)TGCTG reference, missense
rs361689 -- 20,388,160(+) CTTAA(A/C/G)TTCAC intron-variant
rs361764 -- 20,382,025(+) gtgtt(A/G)ctgca intron-variant
rs361766 -- 20,389,481(+) TGGGG(C/T)ATGAC intron-variant

Variation tolerance for USP41 Gene

Gene Damage Index Score: 10.54; 91.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP41 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for USP41 Gene

Disorders for USP41 Gene

Relevant External Links for USP41

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for USP41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP41 Gene

Publications for USP41 Gene

  1. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 3 4 67
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for USP41 Gene

Sources for USP41 Gene

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