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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP40 Gene

protein-coding   GIFtS: 54
GCID: GC02M234384

Ubiquitin Specific Peptidase 40

(Previous name: ubiquitin specific protease 40)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 401 2     Ubiquitin-Specific-Processing Protease 402 3
Ubiquitin Specific Protease 401 2     Ubiquitin Carboxyl-Terminal Hydrolase 402
Deubiquitinating Enzyme 402 3     Ubiquitin Thiolesterase 402
Ubiquitin Thioesterase 402 3     EC 3.4.19.123

External Ids:    HGNC: 200691   Entrez Gene: 552302   Ensembl: ENSG000000859827   OMIM: 6105705   UniProtKB: Q9NVE53   

Export aliases for USP40 gene to outside databases

Previous GC identifers: GC02M234400 GC02M234670 GC02M234168 GC02M234050 GC02M226184


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for USP40 Gene:
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated
action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP40 belongs to a large family of
cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 (PubMed 14715245)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for USP40 Gene: 
USP40 (ubiquitin specific peptidase 40) is a protein-coding gene. Diseases associated with USP40 include crohn's disease, and parkinson's disease. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP24.

UniProtKB/Swiss-Prot: UBP40_HUMAN, Q9NVE5
Function: May be catalytically inactive

Gene Wiki entry for USP40 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005120.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP40 gene promoter:
         Sox5   LHX3b/Lhx3b   AML1a   FOXF2   Brachyury   MyoD   AREB6   Nkx6-1   HSF2   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP40 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP40

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP40


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

USP40 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP40 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M234384:  view genomic region     (about GC identifiers)

Start:
234,384,165 bp from pter      End:
234,475,428 bp from pter
Size:
91,264 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP40_HUMAN, Q9NVE5 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 40  
Size: 1235 amino acids; 140130 Da
Sequence caution: Sequence=BAA91807.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6NX38 Q70EL0
Alternative splicing: 3 isoforms:  Q9NVE5-1   Q9NVE5-2   Q9NVE5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP40: NX_Q9NVE5

Explore proteomics data for USP40 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NVE5

  • USP40 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP40 Protein Expression
    REFSEQ proteins: NP_060688.1  
    ENSEMBL proteins: 
     ENSP00000251722   ENSP00000387898   ENSP00000407696   ENSP00000394133   ENSP00000388121  
     ENSP00000386664   ENSP00000408853   ENSP00000394154   ENSP00000415434  

    Human Recombinant Protein Products for USP40: 
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    OriGene Protein Over-expression Lysate for USP40
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for USP40
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    Novus Biologicals USP40 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP40 


    USP40 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for USP40 

    Assay Products for USP40: 
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    Cloud-Clone Corp. ELISAs for USP40 
    Cloud-Clone Corp. CLIAs for USP40


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    2 InterPro protein domains:
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS

    Graphical View of Domain Structure for InterPro Entry Q9NVE5

    ProtoNet protein and cluster: Q9NVE5

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP40_HUMAN, Q9NVE5
    Similarity: Belongs to the peptidase C19 family


    USP40 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP40_HUMAN, Q9NVE5
    Function: May be catalytically inactive
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IEA--
    GO:0008234cysteine-type peptidase activity IEA--
         
    USP40 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for USP40 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP40

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP40 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP40 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP40
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate USP40
    SwitchGear 3'UTR luciferase reporter plasmidUSP40 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of USP40

    Clone
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    OriGene ORF clones in mouse, rat for USP40
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP40 (NM_018218)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP40
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP40
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                         Customized lentivirus expression plasmids for stable overexpression of USP40 

    Cell Line
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    Search LifeMap BioReagents cell lines for USP40
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP40


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USP40 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP40
        Ubiquitin-Proteasome Dependent Proteolysis


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP40

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for USP40 (Q9NVE53 ENSP000004154344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDB2Q924663, ENSP000002569964I2D: score=1 STRING: ENSP00000256996
    DDB1Q165313, ENSP000003017644I2D: score=1 STRING: ENSP00000301764
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--

    USP40 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP40 (UBP40)

    1 HMDB Compound for USP40    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about USP40 / UBP40

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP40 gene: 
    NM_018218.2  

    Unigene Cluster for USP40:

    Ubiquitin specific peptidase 40
    Hs.96513  [show with all ESTs]
    Unigene Representative Sequence: NM_018218
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483519(uc002vul.3) ENST00000251722(uc010zmu.1) ENST00000427112(uc010zms.1 uc010zmt.1)
    ENST00000464956 ENST00000450940 ENST00000496298 ENST00000454354 ENST00000473191
    ENST00000430158 ENST00000409945(uc002vuo.1) ENST00000483216 ENST00000452724
    ENST00000485943 ENST00000427947 ENST00000484528 ENST00000443711 ENST00000450966(uc010zmr.2)


    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP40
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate USP40
    SwitchGear 3'UTR luciferase reporter plasmidUSP40 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP40
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP40
    Clone
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    OriGene clones in human, mouse for USP40 (see all 7)
    OriGene ORF clones in mouse, rat for USP40
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP40 (NM_018218)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP40
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP40
    Sirion Biotech Customized lentivirus for stable overexpression of USP40 
                         Customized lentivirus expression plasmids for stable overexpression of USP40 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for USP40
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP40
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP40
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP40

    Additional mRNA sequence: 

    AJ583821.2 AK001647.1 AK124094.1 AK295112.1 AK297821.1 AL833371.1 BC013305.1 BC067300.1 
    BC086855.1 

    13 DOTS entries:

    DT.96086321  DT.100744936  DT.445453  DT.100778720  DT.40126574  DT.210036  DT.92038426  DT.120961972 
    DT.95308548  DT.97843925  DT.95374343  DT.40114509  DT.40302635 

    24/204 AceView cDNA sequences (see all 204):

    CB241030 CD370031 CB157786 BM704491 AW080392 BM553538 BM693755 BF940604 
    CA413260 AI218147 AK124094 BU956432 BP432269 BU738195 BQ771950 BM984857 
    BU754477 BX103809 AI183341 BU076627 BU732310 CA445398 AW338435 BE645412 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for USP40 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                    -                                                                                                     -                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23a · 23b · 23c ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28 ^ 29 ^ 30a · 30b · 30c · 30d ^ 31 ^ 32a · 32b
    SP1:              -           -     -     -                                                                     
    SP2:              -                 -     -                                                                     
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                                      -                                                                     


    ECgene alternative splicing isoforms for USP40

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP40 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTGAGCCT
    USP40 Expression
    About this image


    See USP40 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP40

    SOURCE GeneReport for Unigene cluster: Hs.96513

    UniProtKB/Swiss-Prot: UBP40_HUMAN, Q9NVE5
    Tissue specificity: Broadly expressed

        SABiosciences Custom PCR Arrays for USP40
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP40
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP40

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP40 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp401 , 5 ubiquitin specific peptidase 401, 5 83.56(n)1
    79.97(a)1
      1 (44.45 cM)5
    2273341  NM_001198573.11  NP_001185502.11 
     879451215 
    chicken
    (Gallus gallus)
    Aves USP401 ubiquitin carboxyl-terminal hydrolase 40 68.6(n)
    65.08(a)
      100859211  XM_003641561.1  XP_003641609.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP406
    ubiquitin specific peptidase 40
    63(a)
    1 ↔ 1
    1(118796969-118840855)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.266322 Danio rerio cDNA clone IMAGE2601403, partial cds 72.86(n)    BC054934.1 
    worm
    (Caenorhabditis elegans)
    Secernentea usp-486
    Protein USP-48
    12(a)
    1 ↔ 1
    I(9506553-9511185)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP156
    Ubiquitin-specific protease involved in protein de...
    14(a)
    1 → many
    XIII(874987-878679)


    ENSEMBL Gene Tree for USP40 (if available)
    TreeFam Gene Tree for USP40 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP40 gene
    USP242  USP182  USP482  USP412  USP72  USP472  USP342  USP9Y2  
    USP9X2  
    2 SIMAP similar genes for USP40 using alignment to 7 protein entries:     UBP40_HUMAN (see all proteins):
    USP7    USP47

    USP40 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2064 SNPs in USP40 are shown (see all 2064)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898348701,2
    --226276398(+) TAAGAG/TTATAG 1 -- us2k10--------
    rs1819358091,2
    --226276450(+) TAAGAG/TTATAG 1 -- us2k10--------
    rs1456041721,2
    --234383679(+) ATGAGG/TCTGAA 1 -- ds50010--------
    rs1160420361,2
    C,F--234383749(+) ATATAA/GACTGT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs751830011,2
    C,F--234383782(+) TTGGGA/GAAAAG 1 -- ds50012Minor allele frequency- G:0.12WA 120
    rs2001787331,2
    --234383794(+) CCACA-/GAACGT 1 -- ds50010--------
    rs1846698541,2
    --234383795(+) CCACAA/GACGTT 1 -- ds50010--------
    rs29718601,2
    C,F,A,H--234383797(+) ACAAAC/AGTTCC 1 -- ds500116Minor allele frequency- A:0.37NS EA NA WA CSA 868
    rs2012939411,2
    --234383797(+) ACAAA-/CGTTCC 1 -- ds50010--------
    rs1996734801,2
    C--234383803(+) CGTTC-/TTATT 
            
    TATTT
    1 -- ds50010--------

    HapMap Linkage Disequilibrium report for USP40 (234384165 - 234475428 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for USP40:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv768e199CNV Deletion23128226
    nsv508134CNV Loss20534489
    nsv3214CNV Loss18451855
    nsv876013CNV Gain21882294
    nsv7336OTHER Inversion18451855
    nsv499765OTHER Inversion21111241
    esv992038OTHER Inversion20482838
    nsv513646OTHER Inversion21212237
    esv1030429OTHER Inversion17803354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610570    OMIM disorders: --

    2 diseases for USP40:    About MalaCards
    crohn's disease    parkinson's disease


    USP40 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): USP40
    Human Genome Epidemiology (HuGE) Navigator: USP40 (2 documents)

    Export disorders for USP40 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP40 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with USP40)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ubiquitin specific proteases USP24 and USP40 and ubiq uitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Par kinson's disease among Taiwanese. (PubMed id 20302855)1, 4, 9 Wu Y.R....Lee-Chen G.J. (2010)
    2. Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circ ulating bilirubin levels. (PubMed id 21646302)1, 4 Bielinski S.J....Chute C.G. (2011)
    3. Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease. (PubMed id 16917932)1, 4 Li Y....Grupe A. (2006)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (2004)
    8. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    9. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (2012)
    10. Association analysis of single-nucleotide polymorphism s of USP24 and USP40 with Parkinson's disease in the Han Chinese population. (PubMed id 22923019)1 Zhao B....Shang H.F. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55230 HGNC: 20069 AceView: USP40 Ensembl:ENSG00000085982 euGenes: HUgn55230
    ECgene: USP40 H-InvDB: USP40

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP40 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP40 gene:
    Search GeneIP for patents involving USP40

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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