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USP40 Gene

protein-coding   GIFtS: 54
GCID: GC02M234384

Ubiquitin Specific Peptidase 40

(Previous name: ubiquitin specific protease 40)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 401 2     Ubiquitin-Specific-Processing Protease 402 3
Ubiquitin Specific Protease 401 2     Ubiquitin Carboxyl-Terminal Hydrolase 402
Deubiquitinating Enzyme 402 3     Ubiquitin Thiolesterase 402
Ubiquitin Thioesterase 402 3     EC 3.4.19.123

External Ids:    HGNC: 200691   Entrez Gene: 552302   Ensembl: ENSG000000859827   OMIM: 6105705   UniProtKB: Q9NVE53   

Export aliases for USP40 gene to outside databases

Previous GC identifers: GC02M234400 GC02M234670 GC02M234168 GC02M234050 GC02M226184


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USP40 Gene:
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated
action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP40 belongs to a large family of
cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 (PubMed 14715245)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for USP40 Gene:
USP40 (ubiquitin specific peptidase 40) is a protein-coding gene. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP24.

UniProtKB/Swiss-Prot: UBP40_HUMAN, Q9NVE5
Function: May be catalytically inactive

Gene Wiki entry for USP40 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP40 gene promoter:
         Sox5   LHX3b/Lhx3b   AML1a   FOXF2   Brachyury   MyoD   AREB6   Nkx6-1   HSF2   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP40 promoter sequence
   Search Chromatin IP Primers for USP40

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP40


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

USP40 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP40 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M234384:  view genomic region     (about GC identifiers)

Start:
234,384,165 bp from pter      End:
234,475,428 bp from pter
Size:
91,264 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBP40_HUMAN, Q9NVE5 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 40  
Size: 1235 amino acids; 140130 Da
Sequence caution: Sequence=BAA91807.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6NX38 Q70EL0
Alternative splicing: 3 isoforms:  Q9NVE5-1   Q9NVE5-2   Q9NVE5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP40: NX_Q9NVE5

Explore proteomics data for USP40 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See USP40 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060688.1  
    ENSEMBL proteins: 
     ENSP00000251722   ENSP00000387898   ENSP00000407696   ENSP00000394133   ENSP00000388121  
     ENSP00000386664   ENSP00000408853   ENSP00000394154   ENSP00000415434  

    USP40 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for USP40
    OriGene Custom MassSpec
    OriGene Custom Protein Services for USP40
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    Novus Biologicals USP40 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP40

     
    Search eBioscience for Proteins for USP40 

     
    Search antibodies-online for proteins for USP40 

     
    antibodies-online peptides for USP40

    USP40 Antibody Products:

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    antibodies-online antibodies for USP40 (13 products) 

    USP40 Assay Products:

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    Cloud-Clone Corp. ELISAs for USP40
    Cloud-Clone Corp. CLIAs for USP40
    Search eBioscience for ELISAs for USP40 
    antibodies-online kits for USP40 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    3 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028889 UCH/PAN2

    Graphical View of Domain Structure for InterPro Entry Q9NVE5

    ProtoNet protein and cluster: Q9NVE5

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP40_HUMAN, Q9NVE5
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP40           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP40_HUMAN, Q9NVE5
    Function: May be catalytically inactive
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity ----
    GO:0008234cysteine-type peptidase activity IEA--
         
    Find genes that share ontologies with USP40           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for USP40

    miRNA
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    miRTarBase miRNAs that target USP40:
    hsa-mir-484 (MIRT041968)

    Block miRNA regulation of human, mouse, rat USP40 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate USP40
    SwitchGear 3'UTR luciferase reporter plasmidUSP40 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat USP40

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for USP40

    Clone
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    OriGene clones in human, mouse for USP40 (see all 6)
    OriGene ORF clones in mouse, rat for USP40
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP40 (NM_018218)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP40
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP40

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for USP40 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP40


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    peroxisome2
    endoplasmic reticulum1
    extracellular1
    nucleus1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP40 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP40
        Ubiquitin-Proteasome Dependent Proteolysis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP40
    Interactions:

        Search GeneGlobe Interaction Network for USP40

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for USP40 (Q9NVE53 ENSP000004154344) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDB2Q924663, ENSP000002569964I2D: score=1 STRING: ENSP00000256996
    DDB1Q165313, ENSP000003017644I2D: score=1 STRING: ENSP00000301764
    DUS2ENSP000003517694STRING: ENSP00000351769
    HID1ENSP000004135204STRING: ENSP00000413520
    PFASENSP000003134904STRING: ENSP00000313490
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--

    Find genes that share ontologies with USP40           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP40 (UBP40)

    1 HMDB Compound for USP40    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP40 gene: 
    NM_018218.2  

    Unigene Cluster for USP40:

    Ubiquitin specific peptidase 40
    Hs.96513  [show with all ESTs]
    Unigene Representative Sequence: NM_018218
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483519(uc002vul.3) ENST00000251722(uc010zmu.1) ENST00000427112(uc010zms.1 uc010zmt.1)
    ENST00000464956 ENST00000450940 ENST00000496298 ENST00000454354 ENST00000473191
    ENST00000430158 ENST00000409945(uc002vuo.1) ENST00000483216 ENST00000452724
    ENST00000485943 ENST00000427947 ENST00000484528 ENST00000443711 ENST00000450966(uc010zmr.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP40 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate USP40
    SwitchGear 3'UTR luciferase reporter plasmidUSP40 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for USP40
    Predesigned siRNA for gene silencing in human, mouse, rat USP40
    Clone
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    OriGene clones in human, mouse for USP40 (see all 6)
    OriGene ORF clones in mouse, rat for USP40
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP40 (NM_018218)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP40
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP40
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for USP40
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP40
      QuantiTect SYBR Green Assays in human, mouse, rat USP40
      QuantiFast Probe-based Assays in human, mouse, rat USP40

    Additional mRNA sequence: 

    AJ583821.2 AK001647.1 AK124094.1 AK295112.1 AK297821.1 AL833371.1 BC013305.1 BC067300.1 
    BC086855.1 

    13 DOTS entries:

    DT.96086321  DT.100744936  DT.445453  DT.100778720  DT.40126574  DT.210036  DT.92038426  DT.120961972 
    DT.95308548  DT.97843925  DT.95374343  DT.40114509  DT.40302635 

    Selected AceView cDNA sequences (see all 204):

    CN482400 AI970912 AW517683 AW080392 BX103809 CR611364 CA445398 AA127740 
    BQ022772 BU754477 BQ771950 CB157786 BM553538 BE297277 AW338435 AA884336 
    BQ013992 BM673123 BF940604 BU618998 AI183341 AI392789 AA043738 AI926689 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for USP40 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                    -                                                                                                     -                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23a · 23b · 23c ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28 ^ 29 ^ 30a · 30b · 30c · 30d ^ 31 ^ 32a · 32b
    SP1:              -           -     -     -                                                                     
    SP2:              -                 -     -                                                                     
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                                      -                                                                     


    ECgene alternative splicing isoforms for USP40

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP40 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTGAGCCT
    USP40 Expression
    About this image

    USP40 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP40 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.96513

    UniProtKB/Swiss-Prot: UBP40_HUMAN, Q9NVE5
    Tissue specificity: Broadly expressed

        Custom PCR Arrays for USP40
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP40

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP40 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp401 , 5 ubiquitin specific peptidase 401, 5 83.56(n)1
    79.97(a)1
      1 (44.45 cM)5
    2273341  NM_001198573.11  NP_001185502.11 
     879451215 
    chicken
    (Gallus gallus)
    Aves USP401 ubiquitin carboxyl-terminal hydrolase 40 68.58(n)
    65.08(a)
      100859211  NM_001257318.1  NP_001244247.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP406
    ubiquitin specific peptidase 40
    63(a)
    1 ↔ 1
    1(118796969-118840855)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia usp401 ubiquitin specific peptidase 40 58.52(n)
    54.67(a)
      100486255  XM_002932005.2  XP_002932051.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.266322 Danio rerio cDNA clone IMAGE2601403, partial cds 72.86(n)    BC054934.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP156
    Ubiquitin-specific protease involved in protein de...
    16(a)
    1 → many
    XIII(874987-878679) YMR304W


    ENSEMBL Gene Tree for USP40 (if available)
    TreeFam Gene Tree for USP40 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP40 gene
    USP242  USP182  USP482  USP412  USP72  USP472  USP342  USP9Y2  
    USP9X2  
    2 SIMAP similar genes for USP40 using alignment to 7 protein entries:     UBP40_HUMAN (see all proteins):
    USP7    USP47

    Find genes that share paralogs with USP40           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP40 (see all 2064)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898348701,2
    --226276398(+) TAAGAG/TTATAG 1 -- us2k10--------
    rs1819358091,2
    --226276450(+) TAAGAG/TTATAG 1 -- us2k10--------
    rs1456041721,2
    --234383679(+) ATGAGG/TCTGAA 1 -- ds50010--------
    rs1160420361,2
    C,F--234383749(+) ATATAA/GACTGT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs751830011,2
    C,F--234383782(+) TTGGGA/GAAAAG 1 -- ds50012Minor allele frequency- G:0.12WA 120
    rs2001787331,2
    --234383794(+) CCACA-/GAACGT 1 -- ds50010--------
    rs1846698541,2
    --234383795(+) CCACAA/GACGTT 1 -- ds50010--------
    rs29718601,2
    C,F,A,H--234383797(+) ACAAAC/AGTTCC 1 -- ds500116Minor allele frequency- A:0.37NS EA NA WA CSA 868
    rs2012939411,2
    --234383797(+) ACAAA-/CGTTCC 1 -- ds50010--------
    rs1996734801,2
    C--234383803(+) CGTTC-/TTATT 
            
    TATTT
    1 -- ds50010--------

    HapMap Linkage Disequilibrium report for USP40 (234384165 - 234475428 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for USP40:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv768e199CNV Deletion23128226
    nsv508134CNV Loss20534489
    nsv3214CNV Loss18451855
    nsv876013CNV Gain21882294
    nsv7336OTHER Inversion18451855
    nsv499765OTHER Inversion21111241
    esv992038OTHER Inversion20482838
    nsv513646OTHER Inversion21212237
    esv1030429OTHER Inversion17803354

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610570    OMIM disorders: --


    Find genes that share disorders with USP40           About GenesLikeMe

    Genetic Association Database (GAD): USP40
    Human Genome Epidemiology (HuGE) Navigator: USP40 (2 documents)

    Export disorders for USP40 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP40 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with USP40)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese. (PubMed id 20302855)1, 4, 9 Wu Y.R....Lee-Chen G.J. ( international journal of clinical chemistry 2010)
    2. Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels. (PubMed id 21646302)1, 4 Bielinski S.J....Chute C.G. (Mayo Clin. Proc. 2011)
    3. Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease. (PubMed id 16917932)1, 4 Li Y....Grupe A. (Hum. Mutat. 2006)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004)
    8. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    9. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (PLoS Genet. 2012)
    10. Association analysis of single-nucleotide polymorphisms of USP24 and USP40 with Parkinson's disease in the Han Chinese population. (PubMed id 22923019)1 Zhao B....Shang H.F. (Eur. Neurol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55230 HGNC: 20069 AceView: USP40 Ensembl:ENSG00000085982 euGenes: HUgn55230
    ECgene: USP40 H-InvDB: USP40

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for USP40 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for USP40 gene:
    Search GeneIP for patents involving USP40

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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