Aliases for USP4 Gene
External Ids for USP4 Gene
Previous HGNC Symbols for USP4 Gene
Previous GeneCards Identifiers for USP4 Gene
The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for USP4 Gene
USP4 (Ubiquitin Specific Peptidase 4) is a Protein Coding gene. Among its related pathways are TNF signaling (REACTOME) and Metabolism of proteins. GO annotations related to this gene include identical protein binding and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is MIR6125.
UniProtKB/Swiss-Prot for USP4 Gene
Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER.