USP4 Gene
protein-coding GIFtS: 60
GCID: GC03M049290
|
|
ubiquitin specific peptidase 4 (proto-oncogene)(Previous name: ubiquitin specific protease 4 (proto-oncogene) )
(Previous symbol: UNP)
| |
Aliases
for USP4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 4 (Proto-Oncogene)1 2 | | Ubiquitin Carboxyl-Terminal Hydrolase 42 | | UNP1 2 3 5 | | Ubiquitin Thiolesterase 42 | | Unph1 2 | | Ubiquitin-Specific Processing Protease 42 | | Ubiquitin Specific Protease 4 (Proto-Oncogene)1 2 | | EC 3.4.19.123 | | Deubiquitinating Enzyme 42 3 | | UNPH3 | | Ubiquitin Thioesterase 42 3 | | Ubiquitin-Specific-Processing Protease 43 | | Ubiquitous Nuclear Protein Homolog2 3 | | EC 3.1.2.158 | | Ubiquitin Carboxyl-Terminal Esterase 42 | | |
Export aliases for USP4 gene to outside databasesPrevious GC identifers: GC03P048745 GC03P048551 GC03M049160 GC03M049274 |
Summaries
for USP4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for USP4:
The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. Theencoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in theendoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. (providedby RefSeq, Oct 2011)
UniProtKB/Swiss-Prot: UBP4_HUMAN, Q13107Function: Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21.Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. Plays a role in theregulation of quality control in the ER
Gene Wiki entry for USP4
|
Genomic Views
for USP4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP4 gene promoter:
PPAR-gamma1 p53 ATF-2 PPAR-gamma2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3USP4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M049290: view genomic region
(about GC identifiers)
Start:
|
49,314,577 bp from pter |
End:
|
49,378,145 bp from pter |
Size:
|
63,569 bases |
Orientation:
|
minus strand |
|
Proteins
for USP4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP4_HUMAN, Q13107 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 4 Size: 963 amino acids; 108565 Da
Subunit: Interacts with RB1 (both dephosphorylated and hypophosphorylated forms). Interacts with ADORA2A (viacytoplasmic C-terminus); the interaction is direct. Interacts with RB1, RBL1 and RBL2
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Shuttles between the nucleus andcytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importinalpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according tothe cell type (By similarity)
1 PDB 3D structure from  and Proteopedia  for USP4:2Y6E (3D)
Secondary accessions: A8K6Y0 C9IY91 O43452 O43453 Q08AK8Alternative splicing: 3 isoforms: Q13107-1 Q13107-2 Q13107-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for USP4: NX_Q13107
Post-translational modifications:
Monoubiquitinated by TRIM21. Ubiquitination does not lead to its proteasomal degradation. Autodeubiquitinated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13107
4/25 DME Specific Peptides for USP4 (Q13107) (see all 25)
USP4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001238806.1 NP_003354.2 NP_955475.1
ENSEMBL proteins: ENSP00000341028 ENSP00000265560 ENSP00000399079 ENSP00000400623 ENSP00000408274
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
USP4 for ontologies About GeneDecksing
USP4 Antibody Products:
Assay Products for USP4: |
Protein
Domains /
Families
for USP4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13107ProtoNet protein and cluster: Q13107 3 Blocks protein families: IPB001394 Ubiquitin thiolesterase IPB006615 Ubiquitin-specific protease DUSP IPB010460 Ubiquitin carboxyl-terminal hydrolase
UniProtKB/Swiss-Prot: UBP4_HUMAN, Q13107Domain: The Ubiquitin-like domain 2 inserts into the catalytic domain and competes with the ubiquitin substrate,partially inhibiting DUB activitySimilarity: Belongs to the peptidase C19 family. USP4 subfamilySimilarity: Contains 1 DUSP domainSimilarity: Contains 2 ubiquitin-like domains |
Function
for USP4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBP4_HUMAN, Q13107Function: Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21.Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. Plays a role in theregulation of quality control in the ERCatalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) Genatlas biochemistry entry for USP4:ubiquitin-specific protease 4,homolog to murine Unp,with two tissue specific cytoplasmic isoforms,deubiquitin enzymefamily
Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP4 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): USP4 (NM_001394) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP4 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
USP4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for USP4:
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Usp4):
USP4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for USP4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell Cycle / Checkpoint Control | | | 2 | Ubiquitin-Proteasome Dependent Proteolysis | | | 3 | Protein Stability | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP4
2 
Cell Signaling Technology (CST) Pathways for USP4
USP4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for USP4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/89 Interacting proteins for USP4 (Q131071, 2, 3 ENSP000002655604) via UniProtKB, MINT, STRING, and/or I2D (see all 89)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
USP4 for ontologies About GeneDecksing
|
Drugs & Compounds
for USP4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USP4
1 HMDB Compound for USP4 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Water | Dihydrogen oxide (see all 2) | 7732-18-5 | -- |
Search CenterWatch for drugs/clinical trials and news about USP4 / UBP4
|
Transcripts
for USP4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP4 gene (3 alternative transcripts): NM_001251877.1 NM_003363.3 NM_199443.2 Unigene Cluster for USP4: Ubiquitin specific peptidase 4 (proto-oncogene) Hs.77500 [show with all ESTs]Unigene Representative Sequence: NM_00336314 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000351842(uc003cwq.2 uc003cwr.2) ENST00000265560 ENST00000483212
ENST00000485450(uc003cwp.2) ENST00000431357 ENST00000475873 ENST00000486549
ENST00000488520 ENST00000461553 ENST00000416417(uc021wxv.1) ENST00000415188
ENST00000462673 ENST00000464168 ENST00000491791
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP4 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): USP4 (NM_001394) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP4 |
Additional cDNA sequence: AF017305.1 AF017306.1 AK222725.1 AK223292.1 AK291795.1 BC068017.1 BC110070.1 BC125130.1 BC125131.1 U20657.1 21 DOTS entries: DT.86854615 DT.101954836 DT.100823354 DT.99998877 DT.105378 DT.99950324 DT.120863493 DT.99981740 DT.100823353 DT.75131213 DT.95256634 DT.99955826 DT.120863470 DT.120863484 DT.120863486 DT.120863495 DT.91749359 DT.95095390 DT.95208935 DT.99983351 DT.91673174 24/364 AceView cDNA sequences (see all 364): AW954768 BM465554 BI908596 AA731865 AA303496 BE894900 NM_199443 CF552479 NM_198562 AW852273 AK125642 CR594108 AA102213 BQ950143 AL042366 BC068017 BU741650 H63713 BU159201 BQ670858 BM717170 AA451813 AA075277 BC053629
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for USP4 (see all 11) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | |
| ExUns: | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | · | 22c | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b |
|---|
|
| SP1: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for USP4
|
Expression
for USP4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACACCAACT
About this image
See USP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP4
SOURCE GeneReport for Unigene cluster: Hs.77500
UniProtKB/Swiss-Prot: UBP4_HUMAN, Q13107Tissue specificity: Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (atprotein level). Expressed in the hippocampal neurons
SABiosciences Custom PCR Arrays for USP4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP4 |
Orthologs
for USP4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for USP4 gene from 7/31 species (see all 31) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
USP41 |
ubiquitin specific peptidase 4 (proto-oncogene) |
70.96(n)
72.61(a) |
|
415937 NM_001006134.1 NP_001006134.1 |
lizard
(Anolis carolinensis) |
Reptilia |
USP46 |
-- |
69(a) |
1 ↔ 1 |
2(147443885-147491161) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3984802 |
similar to ubiquitin specific protease 4 (proto-oncogene) |
74.66(n) |
|
BC042353.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BQ481153.12 |
-- |
79.7(n) |
|
334990 BQ481153.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
H34C03.23 |
ubiquitin carboxy-terminal hydrolase |
57(a)
(best of 2) |
|
IV(6757531-6761964) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
UBP51 |
ubiquitin carboxyl-terminal hydrolase 5 |
46.49(n)
38.29(a) |
|
818691 NM_129656.3 NP_565944.1 |
rice
(Oryza sativa) |
Liliopsida |
----(see all 4) |
ubiquitin carboxyl-terminal hydrolase 5, putative,...ubiquitin carboxyl-terminal hydrolase domain conta...(see all 4) |
34(a)32(a)(see all 4) |
many ↔ manymany ↔ many(see all 4) |
10(3830480-3840431) 7(3206123-3213060) |
ENSEMBL Gene Tree for USP4 (if available)
TreeFam Gene Tree for USP4 (if available) |
Paralogs
for USP4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP4 gene
- USP152 USP112 USP312 USP322 USP432 USP192 USP62
5 SIMAP similar genes for USP4 using alignment to 5 protein entries: UBP4_HUMAN (see all proteins):SSNA1 USP15 USP11 USP3 DKFZp761E10121
USP4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for USP4
PGOHUM00000234926
|
Genomic Variants
for USP4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP4 (49314577 - 49378145 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for USP4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP4 |
|
Disorders
/ Diseases
for USP4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP4 for disorders About GeneDecksing
OMIM gene information: 603486
OMIM disorders: --
17  diseases for USP4: About MalaCardsoculopharyngeal muscular dystrophy multiple chemical sensitivity muscular dystrophy hpfh
myocardial infarction acute myocardial infarction herpes simplex insulin resistance
crohn's disease lung carcinoma retinoblastoma neuroblastoma
schizophrenia adenocarcinoma carcinoma malaria
neuronitis
3 Novoseek disease relationships for USP4 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| shock |
0 |
1 |
15750928 (1) |
| tumors |
0 |
3 |
7784062 (2) |
| cancer |
0 |
1 |
16829531 (1) |
Human Genome Epidemiology (HuGE) Navigator: USP4 (2 documents)
Export disorders for USP4 gene to outside databases
|
Publications
for USP4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USP4 gene, integrated from 9 sources (see all 85):
(articles sorted by number of sources associating them with USP4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human UNP locus at 3p21.31 encodes two tissue-selective, cytoplasmic isoforms with deubiquitinating activity that have reduced expression in small cell lung carcinoma cell lines. (PubMed id 9464533)1, 2, 3 Frederick A.... Chiu M.I. (1998)
- Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors. (PubMed id 7784062)1, 2, 9 Gray D.A.... Takahashi T. (1995)
- Ubiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1. (PubMed id 22347420)1, 2 Uras I.Z.... Nijman S.M. (2012)
- Ubiquitin-specific protease 4 is inhibited by its ubi quitin-like domain. (PubMed id 21415856)1, 2 Luna-Vargas M.P....Sixma T.K. (2011)
- UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself. (PubMed id 16472766)1, 2 Wada K. and Kamitani T. (2006)
- The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor. (PubMed id 16339847)1, 2 Milojevic T.... Nanoff C. (2006)
- Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity. (PubMed id 16316627)1, 2 Wada K....Kamitani T. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein. (PubMed id 11571652)1, 2 DeSalle L.M....Loda M. (2001)
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External Searches for USP4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing USP4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing USP4 gene
(According to HUGE)
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Specialized Databases showing USP4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for USP4 gene:
Search GeneIP for patents involving USP4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for USP4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for USP4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP4 | | | OriGene Protein Over-expression Lysate for USP4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for USP4 | | OriGene 3'-UTR Clone for USP4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for USP4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for USP4 | | OriGene Custom Protein Services for USP4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP4 |
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| | Antibodies & Assays for USP4 |
| | | | Search Tocris compounds for USP4 |
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 | | | USP4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP4 |
|  |  |  | | | | ThermoFisher Antibodies for USP4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP4 |
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