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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP39 Gene

protein-coding   GIFtS: 58
GCID: GC02P085829

Ubiquitin Specific Peptidase 39

(Previous name: ubiquitin specific protease 39)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 391 2     SAD12 5
Ubiquitin Specific Protease 391 2     SnRNP Assembly Defective 1 Homolog (S.Cerevisiae)1
Small Nuclear Ribonucleoprotein 65kDa (U4/U6.U5)1 2     HSPC3322
Inactive Ubiquitin-Specific Peptidase 392 3     SNRNP652
65K2 3     SnRNP Assembly Defective 1 Homolog2
SAD1 Homolog2 3     U4/U6.U5 Tri-SnRNP-Associated Protein 22
U4/U6.U5 Tri-SnRNP-Associated 65 KDa Protein2 3     

External Ids:    HGNC: 200711   Entrez Gene: 107132   Ensembl: ENSG000001688837   OMIM: 6115945   UniProtKB: Q53GS93   

Export aliases for USP39 gene to outside databases

Previous GC identifers: GC02P085787 GC02P085804 GC02P085817 GC02P085754


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for USP39 Gene: 
USP39 (ubiquitin specific peptidase 39) is a protein-coding gene. Diseases associated with USP39 include agoraphobia, and generalized anxiety disorder, and among its related super-pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include ubiquitin thiolesterase activity and zinc ion binding.

UniProtKB/Swiss-Prot: SNUT2_HUMAN, Q53GS9
Function: Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks
of the spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle
checkpoint. Does not have ubiquitin-specific peptidase activity, but could be a competitor of ubiquitin
C-terminal hydrolases (UCHs)

Gene Wiki entry for USP39 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP39 gene promoter:
         c-Fos   AP-1   JunB   Brachyury   Fra-1   FosB   Nkx2-5   E47   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP39 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP39

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP39


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

USP39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP39 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P085829:  view genomic region     (about GC identifiers)

Start:
85,829,979 bp from pter      End:
85,876,406 bp from pter
Size:
46,428 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SNUT2_HUMAN, Q53GS9 (See protein sequence)
Recommended Name: U4/U6.U5 tri-snRNP-associated protein 2  
Size: 565 amino acids; 65381 Da
Subunit: Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3,
PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and
USP39
Subcellular location: Nucleus
Sequence caution: Sequence=AAD27730.1; Type=Frameshift; Positions=Several; Sequence=AAG35521.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K086 B3KM40 B4DHT4 D6W5L4 G5E9H0 Q6NX47 Q96RK9 Q9BV89 Q9H381 Q9P050
Q9Y310
Alternative splicing: 3 isoforms:  Q53GS9-1   Q53GS9-2   Q53GS9-3   

Explore the universe of human proteins at neXtProt for USP39: NX_Q53GS9

Explore proteomics data for USP39 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q53GS9

  • USP39 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP39 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001243654.1  NP_001243655.1  NP_001243656.1  NP_001243657.1  NP_006581.2  

    ENSEMBL proteins: 
     ENSP00000396854   ENSP00000392911   ENSP00000386572   ENSP00000386864   ENSP00000312981  
     ENSP00000400690   ENSP00000386803   ENSP00000396133  

    Human Recombinant Protein Products for USP39: 
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    Novus Biologicals USP39 Protein
    Novus Biologicals USP39 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP39 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005681spliceosomal complex IEA--

    USP39 for ontologies           About GeneDecksing



    USP39 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001394 Peptidase_C19
     IPR001607 Znf_UBP
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q53GS9

    ProtoNet protein and cluster: Q53GS9

    2 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB001607 Zn-finger in ubiquitin thiolesterase


    UniProtKB/Swiss-Prot: SNUT2_HUMAN, Q53GS9
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 UBP-type zinc finger


    USP39 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNUT2_HUMAN, Q53GS9
    Function: Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks
    of the spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle
    checkpoint. Does not have ubiquitin-specific peptidase activity, but could be a competitor of ubiquitin
    C-terminal hydrolases (UCHs)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    USP39 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for USP39:
     Decreased viability  Increased cell death in DLD-1   Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for USP39 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP39 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidUSP39 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP39


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USP39 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Spliceosome0.31
    2Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP39
        Ubiquitin-Proteasome Dependent Proteolysis



    1         Kegg Pathway  (Kegg details for USP39):
        Spliceosome


    USP39 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP39

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/817 Interacting proteins for USP39 (Q53GS92, 3 ENSP000003129814) via UniProtKB, MINT, STRING, and/or I2D (see all 817)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF6O949062, 3, ENSP000002660794MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000266079
    PRPF8Q6P2Q92, 3, ENSP000003043504MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000304350
    SART1O432902, 3, ENSP000003104484MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000310448
    SNRNP200O756432, 3, ENSP000003171234MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000317123
    SNRNP40Q96DI72, 3, ENSP000002636944MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000263694
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000245spliceosomal complex assembly TAS10022888
    GO:0006397mRNA processing TAS10022888
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0007049cell cycle IEA--
    GO:0008380RNA splicing TAS10022888

    USP39 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP39 (SNUT2)

    Search CenterWatch for drugs/clinical trials and news about USP39 / SNUT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP39 gene (5 alternative transcripts): 
    NM_001256725.1  NM_001256726.1  NM_001256727.1  NM_001256728.1  NM_006590.3  

    Unigene Cluster for USP39:

    Ubiquitin specific peptidase 39
    Hs.654745  [show with all ESTs]
    Unigene Representative Sequence: NM_006590
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000491659 ENST00000459775(uc002sqb.3) ENST00000474572 ENST00000448971
    ENST00000442708 ENST00000465282 ENST00000409025 ENST00000455732 ENST00000409470(uc002sqe.3)
    ENST00000323701(uc002sqg.3 uc010fgo.3) ENST00000458268 ENST00000409766
    ENST00000493829(uc010fgn.1) ENST00000467885 ENST00000490193 ENST00000481409
    ENST00000496047 ENST00000465514
    miRNA
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: USP39 (NM_006590)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP39
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP39
    Sirion Biotech Customized lentivirus for stable overexpression of USP39 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP39
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP39

    Additional mRNA sequence: 

    AF130096.1 AF132955.1 AF161450.1 AF353989.1 AK001047.1 AK001772.1 AK056334.1 AK129872.1 
    AK222852.1 AK289451.1 AK295257.1 AK302236.1 AL117416.1 BC001384.2 BC067273.1 NR_046347.1 

    24/25 DOTS entries (see all 25):

    DT.453481  DT.100028970  DT.120979877  DT.100819363  DT.100806489  DT.92445228  DT.120979903  DT.100819360 
    DT.100819365  DT.92327725  DT.92409375  DT.95355861  DT.120979861  DT.92445222  DT.100819353  DT.95356169 
    DT.100819351  DT.100819352  DT.120979821  DT.120979879  DT.120979909  DT.91907447  DT.120979806  DT.70101995 

    24/330 AceView cDNA sequences (see all 330):

    CB137541 BM807225 AK056334 BM702549 AI086152 AA908210 F10170 BQ050670 
    CR616188 AI680680 BU171108 AA340847 BM803640 AL038925 AW470698 BQ003938 
    AA863210 AA723501 BU682389 AW262791 BI908033 BX282560 BQ440323 BU189829 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for USP39 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
    SP1:                                                  -                                                                       -                                 
    SP2:                                                  -                                                                       -                                 
    SP3:                                                  -                                                                 -     -                                 
    SP4:                                                                                                                          -                                 
    SP5:                                                                                                                          -     -                           


    ECgene alternative splicing isoforms for USP39

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP39 expression in normal human tissues (normalized intensities)      USP39 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTGAGCTC
    USP39 Expression
    About this image


    USP39 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Mesonephros
     
     Lower Urinary Tract (Urinary System)
             visceral organ/urogenital sinus/primitive bladder   
     
     Testis (Reproductive System)
     
     Ovary (Reproductive System)

    See USP39 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP39

    SOURCE GeneReport for Unigene cluster: Hs.654745
        SABiosciences Custom PCR Arrays for USP39
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP39

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for USP39 gene from 10/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp391 , 5 ubiquitin specific peptidase 391, 5 89.89(n)1
    97.52(a)1
      6 (32.27 cM)5
    280351  NM_138592.41  NP_613058.11 
     723186785 
    chicken
    (Gallus gallus)
    Aves LOC1008590001 U4/U6.U5 tri-snRNP-associated protein 2-like 81.29(n)
    98.25(a)
      100859000  XM_003643466.1  XP_003643514.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP396
    Uncharacterized protein
    96(a)
    1 ↔ 1
    GL343608.1(100315-112352)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX847852.12   -- 80.74(n)    BX847852.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CF997221.12   -- 77.01(n)    CF997221.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG72881 CG7288 62.93(n)
    65.27(a)
      32881  NM_133106.2  NP_573334.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F09D1.11 Protein F09D1.1 57.08(n)
    56.43(a)
      173606  NM_061897.3  NP_494298.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SAD1(YFR005C)4 Conserved zinc-finger domain protein involved in pre-mRNA more   --   6(155873-154527) 850555  NP_116660.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G222851 ubiquitin carboxyl-terminal hydrolase-like protein 55.75(n)
    51.19(a)
      5008155  NM_001084957.1  NP_001078426.1 
    rice
    (Oryza sativa)
    Liliopsida Os.74112 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.15(n)    AK070971.1 


    ENSEMBL Gene Tree for USP39 (if available)
    TreeFam Gene Tree for USP39 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/835 SNPs in USP39 are shown (see all 835)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880591541,2
    --85831828(+) ACCATC/TTTCCT 1 -- int10--------
    rs75840551,2
    C,F--85831834(+) TTCCTG/ACCCAA 1 -- int14Minor allele frequency- A:0.30NA WA CSA 124
    rs606619381,2
    C,F--85841520(+) TAATCG/CCAGCT 6 -- int1 us2k11Minor allele frequency- C:0.00WA 2
    rs1495685941,2
    --85841533(+) TCAGGA/GGTCTG 6 -- us2k1 int10--------
    rs101904281,2
    C--85841558(+) cttgaC/Acccag 6 -- int1 us2k12Minor allele frequency- A:0.33WA CSA 3
    rs1389394421,2
    --85841602(+) AATGCA/CCTCCA 6 -- us2k1 int10--------
    rs1164832451,2
    F--85841698(+) GTTCCT/CGAAAG 6 -- us2k1 int11Minor allele frequency- C:0.02WA 118
    rs133849011,2
    H--85841716(+) aggaaC/Ggcatc 6 -- int1 us2k14Minor allele frequency- G:0.00NS EA 418
    rs1852934801,2
    --85841766(+) GATCAC/TGGGGA 6 -- us2k1 int10--------
    rs1901074411,2
    --85841888(+) TTGGGA/TTATTA 6 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for USP39 (85829979 - 85876406 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for USP39:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv4202n71CNV Loss21882294
    nsv215431CNV Loss16902084

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing USP39
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611594    OMIM disorders: --

    4 diseases for USP39:    About MalaCards
    agoraphobia    generalized anxiety disorder    anxiety disorder    panic disorder

    3 diseases from the University of Copenhagen DISEASES database for USP39:
    Panic disorder     Agoraphobia     Generalized anxiety disorder

    USP39 for disorders           About GeneDecksing

    Genetic Association Database (GAD): USP39
    Human Genome Epidemiology (HuGE) Navigator: USP39 (1 document)

    Export disorders for USP39 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP39 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with USP39)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B. (PubMed id 18728397)1, 2 van Leuken R.J....Medema R.H. (2008)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    7. The 65 and 110 kDa SR-related proteins of the U4/U6*U5 tri-snRNP are essential for the assembly of mature spliceosomes. (PubMed id 11350945)1, 2 Makarova O.V.... Luehrmann R. (2001)
    8. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10713 HGNC: 20071 AceView: USP39 Ensembl:ENSG00000168883 euGenes: HUgn10713
    ECgene: USP39 Kegg: 10713 H-InvDB: USP39

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP39 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP39 gene:
    Search GeneIP for patents involving USP39

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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