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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

USP39 Gene

protein-coding GIFtS: 57
GCID: GC02P085829

ubiquitin specific peptidase 39

(Previous name: ubiquitin specific protease 39 )

Explore 2 diseases affiliated with
USP39 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 39¹ ²		U4/U6.U5 Tri-SnRNP-Associated 65 KDa Protein² ³
SAD1¹ ² ⁵		CGI-21¹
SNRNP65¹ ²		HSPC332²
Ubiquitin Specific Protease 39¹ ²		Small Nuclear Ribonucleoprotein 65kDa (U4/U6.U5)²
Inactive Ubiquitin-Specific Peptidase 39² ³		SnRNP Assembly Defective 1 Homolog²
65K² ³		U4/U6.U5 Tri-SnRNP-Associated Protein 2²
SAD1 Homolog² ³

External Ids:	HGNC: 20071¹	Entrez Gene: 10713²	Ensembl: ENSG00000168883⁷	OMIM: 611594⁵	UniProtKB: Q53GS9³

Export aliases for USP39 gene to outside databases

Previous GC identifers: GC02P085787 GC02P085804 GC02P085817 GC02P085754

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SNUT2_HUMAN, Q53GS9

Function: Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the

spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does

not have ubiquitin-specific peptidase activity, but could be a competitor of ubiquitin C-terminal hydrolases (UCHs)

Gene Wiki entry for USP39

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the USP39 gene promoter:
c-Fos AP-1 JunB Brachyury Fra-1 FosB Nkx2-5 E47 JunD c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: USP39 promoter sequence

Search SABiosciences Chromatin IP Primers for USP39

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP39

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2

USP39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP39 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P085829: view genomic region (about GC identifiers)

Start:	85,829,979 bp from pter	End:	85,876,406 bp from pter
Size:	46,428 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SNUT2_HUMAN, Q53GS9 (See protein sequence)

Recommended Name: U4/U6.U5 tri-snRNP-associated protein 2

Size: 565 amino acids; 65381 Da

Subunit: Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4,

PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39

Subcellular location: Nucleus

Sequence caution: Sequence=AAD27730.1; Type=Frameshift; Positions=Several; Sequence=AAG35521.1; Type=Erroneous

initiation;

Secondary accessions: A8K086 B4DHT4 D6W5L4 Q6NX47 Q96RK9 Q9BV89 Q9H381 Q9P050 Q9Y310

Alternative splicing: 2 isoforms: Q53GS9-1 Q53GS9-2

Explore the universe of human proteins at neXtProt for USP39: NX_Q53GS9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q53GS9

USP39 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001243654.1 NP_001243655.1 NP_001243656.1 NP_001243657.1 NP_006581.2

ENSEMBL proteins:

ENSP00000396854 ENSP00000392911 ENSP00000387175 ENSP00000386572 ENSP00000386864

ENSP00000312981 ENSP00000400690 ENSP00000386803 ENSP00000396133

Human Recombinant Protein Products for USP39:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	OriGene Purified Protein: USP39 OriGene Protein Over-expression Lysate: USP39 OriGene Custom Protein Services for USP39
	GenScript Custom Purified and Recombinant Proteins Services for USP39
	Novus Biologicals USP39 Protein Novus Biologicals USP39 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for USP39

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

USP39 for ontologies About GeneDecksing

USP39 Antibody Products:

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	Novus Biologicals USP39 Antibodies
	Abcam antibodies for USP39
	Uscn Antibodies for USP39
	Search ThermoFisher Antibodies for USP39

Assay Products for USP39:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for USP39
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for USP39

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

USP39 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001394 Peptidase_C19

IPR001607 Znf_UBP

IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q53GS9

ProtoNet protein and cluster: Q53GS9

2 Blocks protein families:

IPB001394 Ubiquitin thiolesterase

IPB001607 Zn-finger in ubiquitin thiolesterase

UniProtKB/Swiss-Prot: SNUT2_HUMAN, Q53GS9

Similarity: Belongs to the peptidase C19 family

Similarity: Contains 1 UBP-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SNUT2_HUMAN, Q53GS9

Function: Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the

spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does

not have ubiquitin-specific peptidase activity, but could be a competitor of ubiquitin C-terminal hydrolases (UCHs)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004221	ubiquitin thiolesterase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--

USP39 for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for USP39:

Decreased viability

Increased cell death in DLD-1

Increased gamma-H2AX phosphory

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for USP39

miRNA Products:		OriGene 3'-UTR Clone: USP39 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP39
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate USP39
		SwitchGear 3'UTR luciferase reporter plasmid: USP39 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP39 (see all 7) OriGene shRNA RFP: USP39 OriGene siRNA: USP39
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP39
		Sirion Biotech Custom design and validation of potent shRNA sequences against USP39

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for USP39
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP39 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP39 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: USP39 (NM_006590)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP39

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for USP39
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		Sirion Biotech Customized stable knockdown cell line services for USP39 Sirion Biotech Customized inducible knockdown cell line services for USP39 Sirion Biotech Customized stable overexpressing cell line services for USP39 Sirion Biotech Customized inducible overexpressing cell line services for USP39

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP39

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitin-Proteasome Dependent Proteolysis

Ubiquitin-Proteasome Dependent Proteolysis

1.00

mRNA Splicing - Major Pathway

Spliceosome

0.31

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP39

Ubiquitin-Proteasome Dependent Proteolysis

1 Kegg Pathway (Kegg details for USP39):

Spliceosome

USP39 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for USP39

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/780 Interacting proteins for USP39 (Q53GS9^{2, 3} ENSP00000312981⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 780)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRPF6	O94906²^,³, ENSP00000266079⁴	MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000266079
PRPF8	Q6P2Q9²^,³, ENSP00000304350⁴	MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000304350
SART1	O43290²^,³, ENSP00000310448⁴	MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000310448
SNRNP200	O75643²^,³, ENSP00000317123⁴	MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000317123
SNRNP40	Q96DI7²^,³, ENSP00000263694⁴	MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000263694

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000245	spliceosomal complex assembly	TAS	10022888
GO:0006397	mRNA processing	TAS	10022888
GO:0006511	ubiquitin-dependent protein catabolic process	IEA	--
GO:0008380	RNA splicing	TAS	10022888

USP39 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for USP39
Search CenterWatch for drugs/clinical trials and news about USP39 / SNUT2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for USP39 gene (5 alternative transcripts):

NM_001256725.1 NM_001256726.1 NM_001256727.1 NM_001256728.1 NM_006590.3

Unigene Cluster for USP39:

Ubiquitin specific peptidase 39

Hs.654745 [show with all ESTs]

Unigene Representative Sequence: NM_006590

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000491659 ENST00000459775(uc002sqb.3) ENST00000474572 ENST00000448971

ENST00000442708 ENST00000465282 ENST00000409268 ENST00000409025 ENST00000455732

ENST00000409470(uc002sqe.3) ENST00000323701(uc002sqg.3 uc010fgo.3)

ENST00000458268 ENST00000409766 ENST00000493829(uc010fgn.1) ENST00000467885

ENST00000490193 ENST00000481409 ENST00000496047

miRNA Products:		OriGene 3'-UTR Clone: USP39 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP39
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate USP39
		SwitchGear 3'UTR luciferase reporter plasmid: USP39 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP39 (see all 7) OriGene shRNA RFP: USP39 OriGene siRNA: USP39
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP39
		Sirion Biotech Custom design and validation of potent shRNA sequences against USP39

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP39 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP39 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: USP39 (NM_006590)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP39
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP39

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP39 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat USP39
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP39
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP39

Additional cDNA sequence:

AF130096.1 AF132955.1 AF161450.1 AF353989.1 AK001047.1 AK001772.1 AK056334.1 AK129872.1

AK222852.1 AK289451.1 AK295257.1 AK302236.1 AL117416.1 BC001384.2 BC067273.1 NR_046347.1

24/25 DOTS entries (see all 25):

DT.453481 DT.100028970 DT.120979877 DT.100819363 DT.100806489 DT.92445228 DT.120979903 DT.100819360

DT.100819365 DT.92327725 DT.92409375 DT.95355861 DT.120979861 DT.92445222 DT.100819353 DT.95356169

DT.100819351 DT.100819352 DT.120979821 DT.120979879 DT.120979909 DT.91907447 DT.120979806 DT.70101995

24/330 AceView cDNA sequences (see all 330):

BM785246 AW778920 AW470698 AI521917 BU171108 CN481374 BM826565 BQ003938

BQ232867 BM702549 AI250751 AK056334 BQ050670 BE895061 BM807225 AI689752

BU189829 AA977168 AA908210 AI690796 BX282560 AU118856 AL038925 CK821632

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for USP39 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	·	15c
SP1:																	-																								-
SP2:																	-																								-
SP3:																	-																						-		-
SP4:																																									-
SP5:																																									-		-

ECgene alternative splicing isoforms for USP39

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

USP39 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTGAGCTC

About this image

USP39 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Reproductive System

Mesonephros

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See USP39 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP39

SOURCE GeneReport for Unigene cluster: Hs.654745

SABiosciences Custom PCR Arrays for USP39

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP39 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP39
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP39

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP39

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for USP39 gene from 9/37 species (see all 37) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Usp39^{1 , 5}	ubiquitin specific peptidase 39^{1, 5}	89.89(n)¹ 97.52(a)¹		6 (32.27 cM)⁵ 28035¹ NM_138592.4¹ NP_613058.1¹ 72318678⁵
chicken (Gallus gallus)	Aves	LOC100859000¹	U4/U6.U5 tri-snRNP-associated protein 2-like	81.29(n) 98.25(a)		100859000 XM_003643466.1 XP_003643514.1
lizard (Anolis carolinensis)	Reptilia	USP39⁶	--	97(a)	1 ↔ 1	GL343608.1(102965-112352)
African clawed frog (Xenopus laevis)	Amphibia	BX847852.1²	--	80.74(n)		BX847852.1
zebrafish (Danio rerio)	Actinopterygii	CF997221.1²	--	77.01(n)		CF997221.1
fruit fly (Drosophila melanogaster)	Insecta	CG7288¹	CG7288	62.93(n) 65.27(a)		32881 NM_133106.2 NP_573334.1
worm (Caenorhabditis elegans)	Secernentea	F09D1.1¹	Protein F09D1.1	57.08(n) 56.43(a)		173606 NM_061897.3 NP_494298.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G22285¹	ubiquitin carboxyl-terminal hydrolase-like protein	55.75(n) 51.19(a)		5008155 NM_001084957.1 NP_001078426.1
rice (Oryza sativa)	Liliopsida	Os.7411²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	73.15(n)		AK070971.1

ENSEMBL Gene Tree for USP39 (if available)
TreeFam Gene Tree for USP39 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6733550^1,2	C,F,H	--	85828014(+)	`AACTGG/TCAAGT`	3	--	us2k¹ int¹		25		NS EA NA WA CSA	2348
rs183813286^1,2	C	--	85828101(+)	`CTGGGA/GGGCCC`	3	--	us2k¹ int¹		0	--	--	--	--
rs201701425^1,2		--	85828246(+)	`GGACAA/GGGAGT`	3	--	int¹ us2k¹		0	--	--	--	--
rs144789239^1,2		--	85828481(+)	`TGGCTC/TGTGGC`	3	--	us2k¹ int¹		0	--	--	--	--
rs188614178^1,2		--	85828764(+)	`AGCACC/GTGCAG`	3	--	int¹ us2k¹		0	--	--	--	--
rs79411517^1,2	C	--	85828860(+)	`AGCTTA/GTCCCA`	3	--	int¹ us2k¹		0	--	--	--	--
rs76100327^1,2	C	--	85828861(+)	`GCTTGC/TCCCAA`	3	--	us2k¹ int¹		0	--	--	--	--
rs77912960^1,2	C	--	85828862(+)	`CTTGTA/CCCAAG`	3	--	us2k¹ int¹		0	--	--	--	--
rs3827550^1,2	C,F,H	--	85828972(+)	`TCAAGC/GTCCTG`	3	--	int¹ us2k¹		15		NA EA NS WA CSA EU	1577
rs200494704^1,2	C	--	85828986(+)	`CCCCCC/GGGGCA`	3	--	int¹ us2k¹		1		EU	625

HapMap Linkage Disequilibrium report for USP39 (85829979 - 85876406 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for USP39
2 CNVs: 39256 5988

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

USP39 for disorders           About GeneDecksing

OMIM gene information: 611594    OMIM disorders: --

2 diseases for USP39:    About MalaCards

agoraphobia malaria

3 diseases from the University of Copenhagen DISEASES database for USP39:

Panic disorder Agoraphobia Generalized anxiety disorder

Human Genome Epidemiology (HuGE) Navigator: USP39 (1 document)

Export disorders for USP39 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for USP39 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with USP39)

Utopia: connect your pdf to the dynamic
world of online information

Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B. (PubMed id 18728397)^{1, 2} van Leuken R.J....Medema R.H. (2008)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)^{1, 3} Puente X.S.... Lopez-Otin C. (2003)
The 65 and 110 kDa SR-related proteins of the U4/U6*U5 tri-snRNP are essential for the assembly of mature spliceosomes. (PubMed id 11350945)^{1, 2} Makarova O.V.... Luehrmann R. (2001)
Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{1, 2} Lai C.H....Lin W. (2000)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)¹ Naji S....Gerace L. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10713	HGNC: 20071	AceView: USP39	Ensembl:ENSG00000168883	euGenes: HUgn10713
ECgene: USP39	Kegg: 10713	H-InvDB: USP39

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for USP39	Pharmacogenomics, SNPs, Pathways

Intellectual Property for USP39 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for USP39 gene:
Search GeneIP for patents involving USP39

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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ubiquitin specific peptidase 39

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USP39 Gene

ubiquitin specific peptidase 39

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