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USP38 Gene

protein-coding   GIFtS: 51
GCID: GC04P144106

Ubiquitin Specific Peptidase 38

(Previous name: ubiquitin specific protease 38)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 381 2     HP43.8KD2 3
Ubiquitin Specific Protease 381 2     Ubiquitin Carboxyl-Terminal Hydrolase 382
Deubiquitinating Enzyme 382 3     Ubiquitin Thiolesterase 382
Ubiquitin Thioesterase 382 3     EC 3.4.19.123
Ubiquitin-Specific-Processing Protease 382 3     KIAA18913

External Ids:    HGNC: 200671   Entrez Gene: 846402   Ensembl: ENSG000001701857   UniProtKB: Q8NB143   

Export aliases for USP38 gene to outside databases

Previous GC identifers: GC04P144572 GC04P144683 GC04P144463 GC04P144325 GC04P139835


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for USP38 Gene:
USP38 (ubiquitin specific peptidase 38) is a protein-coding gene. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP35.

UniProtKB/Swiss-Prot: UBP38_HUMAN, Q8NB14
Function: Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked Ubiquitin chains




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP38 gene promoter:
         Meis-1b   E47   GATA-1   C/EBPalpha   Max   Egr-2   AREB6   Zic1   Meis-1a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP38 promoter sequence
   Search Chromatin IP Primers for USP38

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP38


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  4q31.21   HGNC cytogenetic band: 4q31.1

USP38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP38 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P144106:  view genomic region     (about GC identifiers)

Start:
144,106,070 bp from pter      End:
144,144,983 bp from pter
Size:
38,914 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBP38_HUMAN, Q8NB14 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 38  
Size: 1042 amino acids; 116546 Da
Sequence caution: Sequence=AAK26248.1; Type=Erroneous initiation; Sequence=BAB71627.1; Type=Erroneous initiation;
Sequence=BAC03730.1; Type=Miscellaneous discrepancy; Note=The absence of the residues from Tyr-840 to Ser-871 is
not the result of an alternative splicing;
Secondary accessions: B3KX93 Q8NDF5 Q96DK6 Q96PZ6 Q9BY55

Explore the universe of human proteins at neXtProt for USP38: NX_Q8NB14

Explore proteomics data for USP38 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys773
  • Modification sites at PhosphoSitePlus

  • See USP38 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001277254.1  NP_001277255.1  NP_115946.2  

    ENSEMBL proteins: 
     ENSP00000427647   ENSP00000303434   ENSP00000424158  

    USP38 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for USP38
    OriGene Protein Over-expression Lysate for USP38
    OriGene MassSpec for USP38
    OriGene Custom Protein Services for USP38
    GenScript Custom Purified and Recombinant Proteins Services for USP38
    Novus Biologicals USP38 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP38

     
    Search eBioscience for Proteins for USP38 

     
    Search antibodies-online for proteins for USP38 

     
    antibodies-online peptides for USP38

    USP38 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals USP38 Antibodies
    Abcam antibodies for USP38
    Cloud-Clone Corp. Antibodies for USP38
    Search ThermoFisher Antibodies for USP38
    antibodies-online antibodies for USP38 (26 products) 

    USP38 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP38
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP38
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP38
    Cloud-Clone Corp. CLIAs for USP38
    Search eBioscience for ELISAs for USP38 
    antibodies-online kits for USP38 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    3 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028889 UCH/PAN2

    Graphical View of Domain Structure for InterPro Entry Q8NB14

    ProtoNet protein and cluster: Q8NB14

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP38_HUMAN, Q8NB14
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP38           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP38_HUMAN, Q8NB14
    Function: Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked Ubiquitin chains
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity ----
    GO:0004843ubiquitin-specific protease activity IDA14715245
    GO:0008234cysteine-type peptidase activity ----
         
    Find genes that share ontologies with USP38           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for USP38:
     Increased S DNA content  Increased cell death HMECs cel  Increased number of mitotic ce  Synthetic lethal with Ras 
     Synthetic lethal with c-Myc af 

         1 MGI phenotypic allele for Usp38 (no phenotypes)

    Find genes that share phenotypes with USP38           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for USP38

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP38:
    hsa-mir-148a-3p (MIRT048041), hsa-mir-124-3p (MIRT023119), hsa-mir-17-5p (MIRT050808)

    Block miRNA regulation of human, mouse, rat USP38 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP38 (see all 31):
    hsa-miR-217 hsa-miR-875-3p hsa-miR-125a-5p hsa-miR-137 hsa-let-7d hsa-miR-509-5p hsa-miR-1278 hsa-let-7c
    SwitchGear 3'UTR luciferase reporter plasmidUSP38 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP38
    Predesigned siRNA for gene silencing in human, mouse, rat USP38

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP38

    Clone
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    OriGene clones in human, mouse for USP38 (see all 6)
    OriGene ORF clones in mouse, rat for USP38
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP38 (NM_032557)
    Sino Biological Human cDNA Clone for USP38
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP38
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP38
    Addgene plasmids for USP38 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for USP38 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP38


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    golgi apparatus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP38 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    2Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP38
        Ubiquitin-Proteasome Dependent Proteolysis

    1 BioSystems Pathway for USP38
        Integrated Breast Cancer Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP38
    Interactions:

        Search GeneGlobe Interaction Network for USP38

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for USP38 (Q8NB143 ENSP000003034344) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LGALS7P479293, ENSP000003678914I2D: score=2 STRING: ENSP00000367891
    HSPB1P047923, ENSP000002485534I2D: score=2 STRING: ENSP00000248553
    LGALS7BP479293I2D: score=2 
    HMX2A2RU543, ENSP000003411084STRING: ENSP00000341108 I2D: score=1 
    HMX3A6NHT53, ENSP000003505494STRING: ENSP00000350549 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016579protein deubiquitination IDA14715245

    Find genes that share ontologies with USP38           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP38 (UBP38)

    1 HMDB Compound for USP38    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP38 gene (3 alternative transcripts): 
    NM_001290325.1  NM_001290326.1  NM_032557.6  

    Unigene Cluster for USP38:

    Ubiquitin specific peptidase 38
    Hs.480848  [show with all ESTs]
    Unigene Representative Sequence: NM_032557
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510377(uc003ija.4) ENST00000307017(uc003ijb.3 uc003ijc.3)
    ENST00000511739
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP38 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP38 (see all 31):
    hsa-miR-217 hsa-miR-875-3p hsa-miR-125a-5p hsa-miR-137 hsa-let-7d hsa-miR-509-5p hsa-miR-1278 hsa-let-7c
    SwitchGear 3'UTR luciferase reporter plasmidUSP38 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for USP38
    Predesigned siRNA for gene silencing in human, mouse, rat USP38
    Clone
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    OriGene clones in human, mouse for USP38 (see all 6)
    OriGene ORF clones in mouse, rat for USP38
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP38 (NM_032557)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP38
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP38
    Addgene plasmids for USP38 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for USP38
    OriGene qSTAR qPCR primer pairs in human, mouse for USP38
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP38
      QuantiTect SYBR Green Assays in human, mouse, rat USP38
      QuantiFast Probe-based Assays in human, mouse, rat USP38

    Additional mRNA sequence: 

    AB067478.1 AF211481.1 AK057992.1 AK091712.1 AK093289.1 AK093754.1 AK126943.1 AL833976.1 
    BC017668.2 BC039115.1 BC068975.1 

    12 DOTS entries:

    DT.99984634  DT.443246  DT.97827058  DT.100815561  DT.99937617  DT.100815558  DT.95090603  DT.121245871 
    DT.75161200  DT.99940200  DT.100815559  DT.91945005 

    Selected AceView cDNA sequences (see all 164):

    BX396124 AW197132 AW571778 AW007250 F08122 CA393804 BF913945 AL833976 
    AK093754 AA284365 BM452222 BX488016 BF033560 CR619187 AX748035 AV708779 
    AW511527 AI770148 BC068975 Z45502 BC017668 AA476948 AK126943 AI863678 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP38 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    USP38 Expression
    About this image

    USP38 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP38 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.480848

    UniProtKB/Swiss-Prot: UBP38_HUMAN, Q8NB14
    Tissue specificity: Highly expressed in skeletal muscle. Expressed in adrenal gland

        Custom PCR Arrays for USP38
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    QuantiFast Probe-based Assays in human, mouse, rat USP38
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP38

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP38 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp381 , 5 ubiquitin specific peptidase 381, 5 87.46(n)1
    90.12(a)1
      8 (38.68 cM)5
    748411  NM_027554.21  NP_081830.21 
     809807345 
    chicken
    (Gallus gallus)
    Aves USP381 ubiquitin specific peptidase 38 73.82(n)
    75.24(a)
      422455  XM_420421.4  XP_420421.3 
    lizard
    (Anolis carolinensis)
    Reptilia USP386
    ubiquitin specific peptidase 38
    71(a)
    1 ↔ 1
    5(118707144-118726822)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.101042 Transcribed sequence with weak similarity to protein refNP_115946.1 (H.sapiens) HP43.8KD protein; KIAA1891 protein [Homo sapiens] less 79.73(n)    142003899 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.153832 Transcribed sequence with weak similarity to protein spO75317 (H.sapiens) UBPC_HUMAN Ubiquitin carboxyl-terminal hydrolase 12 (Ubiquitin thiolesterase 12) (Ubiquitin-specific processing protease 12) (Deubiquitinating enzyme 12) (Ubiquitin hydrolyzing en less 74.25(n)    57060514 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG88306
    --
    29(a)
    1 → many
    2R(8319407-8324082)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP136
    UBP96
    Putative ubiquitin carboxyl-terminal hydrolase, ub...
    Ubiquitin carboxyl-terminal hydrolase, ubiquitin-s...
    18(a)
    17(a)
    many ↔ many
    many ↔ many
    II(93639-95882) YBL067C
    V(355466-357730) YER098W


    ENSEMBL Gene Tree for USP38 (if available)
    TreeFam Gene Tree for USP38 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP38 gene
    USP352  USP122  USP462  USP12  
    3 SIMAP similar genes for USP38 using alignment to 3 protein entries:     UBP38_HUMAN (see all proteins):
    C4orf21    ZNF212    USP35

    Find genes that share paralogs with USP38           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP38 (see all 716)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs126406981,2
    C,F,A,H--144104094(+) TTATAC/TGAAAT 1 -- us2k114Minor allele frequency- T:0.17NA WA CSA EA 378
    rs793935471,2
    C,F--144104651(+) CATTCG/ATCCTG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs757957181,2
    C--144104666(+) TTTCTG/TAGCAC 1 -- us2k10--------
    rs1897737051,2
    --144104714(+) TCCACA/GATCCT 1 -- us2k10--------
    rs111007791,2
    C,F,H--144104764(+) ATTACT/CTTTGT 1 -- us2k116Minor allele frequency- C:0.17NS EA NA WA CSA 781
    rs1431612001,2
    --144104854(+) TAGCAC/TGACTG 1 -- us2k10--------
    rs111007801,2
    C,F,A,H--144104906(+) CCTACA/GAGTCA 1 -- us2k122Minor allele frequency- G:0.35NS EA NA WA CSA 2344
    rs1482064141,2
    --144105315(+) CAACAC/TATACA 1 -- us2k10--------
    rs1411464011,2
    C--144105357(+) TATTTC/TCAAAG 1 -- us2k10--------
    rs1473875531,2
    --144105374(+) TGTATA/GACACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for USP38 (144106070 - 144144983 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for USP38:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv270292CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP38
    DNA2.0 Custom Variant and Variant Library Synthesis for USP38

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with USP38           About GenesLikeMe

    Genetic Association Database (GAD): USP38

    Export disorders for USP38 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP38 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with USP38)
        Utopia: connect your pdf to the dynamic
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    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004)
    4. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    5. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    6. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    7. Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes. (PubMed id 22689415)2 Iphofer A.... Franke R. (ChemBioChem 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84640 HGNC: 20067 AceView: USP38 Ensembl:ENSG00000170185 euGenes: HUgn84640
    ECgene: USP38 H-InvDB: USP38

    (According to HUGE)
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    HUGE: KIAA1891

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP38 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP38 gene:
    Search GeneIP for patents involving USP38

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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