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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP38 Gene

protein-coding   GIFtS: 50
GCID: GC04P144106

Ubiquitin Specific Peptidase 38

(Previous name: ubiquitin specific protease 38)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 381 2     HP43.8KD2 3
Ubiquitin Specific Protease 381 2     Ubiquitin Carboxyl-Terminal Hydrolase 382
Deubiquitinating Enzyme 382 3     Ubiquitin Thiolesterase 382
Ubiquitin Thioesterase 382 3     EC 3.4.19.123
Ubiquitin-Specific-Processing Protease 382 3     KIAA18913

External Ids:    HGNC: 200671   Entrez Gene: 846402   Ensembl: ENSG000001701857   UniProtKB: Q8NB143   

Export aliases for USP38 gene to outside databases

Previous GC identifers: GC04P144572 GC04P144683 GC04P144463 GC04P144325 GC04P139835


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for USP38 Gene: 
USP38 (ubiquitin specific peptidase 38) is a protein-coding gene. Diseases associated with USP38 include pancreatic cancer, and pancreatitis. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP35.

UniProtKB/Swiss-Prot: UBP38_HUMAN, Q8NB14
Function: Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked Ubiquitin chains




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP38 gene promoter:
         Meis-1b   E47   GATA-1   C/EBPalpha   Max   Egr-2   AREB6   Zic1   Meis-1a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP38 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP38

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP38


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  4q31.21   HGNC cytogenetic band: 4q31.1

USP38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP38 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P144106:  view genomic region     (about GC identifiers)

Start:
144,106,070 bp from pter      End:
144,144,983 bp from pter
Size:
38,914 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP38_HUMAN, Q8NB14 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 38  
Size: 1042 amino acids; 116546 Da
Sequence caution: Sequence=AAK26248.1; Type=Erroneous initiation; Sequence=BAB71627.1; Type=Erroneous initiation;
Sequence=BAC03730.1; Type=Miscellaneous discrepancy; Note=The absence of the residues from Tyr-840 to Ser-871 is
not the result of an alternative splicing;
Secondary accessions: B3KX93 Q8NDF5 Q96DK6 Q96PZ6 Q9BY55

Explore the universe of human proteins at neXtProt for USP38: NX_Q8NB14

Explore proteomics data for USP38 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NB14

  • USP38 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP38 Protein Expression
    REFSEQ proteins: NP_115946.2  
    ENSEMBL proteins: 
     ENSP00000427647   ENSP00000303434   ENSP00000424158  

    Human Recombinant Protein Products for USP38: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for USP38
    OriGene MassSpec for USP38 
    OriGene Custom Protein Services for USP38
    GenScript Custom Purified and Recombinant Proteins Services for USP38
    Novus Biologicals USP38 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP38 


    USP38 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for USP38 

    Assay Products for USP38: 
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    Cloud-Clone Corp. ELISAs for USP38 
    Cloud-Clone Corp. CLIAs for USP38


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    2 InterPro protein domains:
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS

    Graphical View of Domain Structure for InterPro Entry Q8NB14

    ProtoNet protein and cluster: Q8NB14

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP38_HUMAN, Q8NB14
    Similarity: Belongs to the peptidase C19 family


    USP38 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP38_HUMAN, Q8NB14
    Function: Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked Ubiquitin chains
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IEA--
    GO:0008234cysteine-type peptidase activity IEA--
         
    USP38 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for USP38:
     Increased S DNA content  Increased cell death HMECs cel  Increased number of mitotic ce  Synthetic lethal with Ras 
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for USP38 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for USP38

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP38 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP38 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP38
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate USP38 (see all 31):
    hsa-miR-217 hsa-miR-875-3p hsa-miR-125a-5p hsa-miR-137 hsa-let-7d hsa-miR-509-5p hsa-miR-1278 hsa-let-7c
    SwitchGear 3'UTR luciferase reporter plasmidUSP38 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP38
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of USP38

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for USP38
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP38 (NM_032557)
    Sino Biological Human cDNA Clone for USP38
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP38
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP38
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                         Customized lentivirus expression plasmids for stable overexpression of USP38 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP38


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USP38 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    2Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP38
        Ubiquitin-Proteasome Dependent Proteolysis

    1 BioSystems Pathway for USP38
        Integrated Breast Cancer Pathway



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP38

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for USP38 (Q8NB143 ENSP000003034344) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LGALS7P479293, ENSP000003678914I2D: score=2 STRING: ENSP00000367891
    HSPB1P047923, ENSP000002485534I2D: score=2 STRING: ENSP00000248553
    LGALS7BP479293I2D: score=2 
    HMX2A2RU543, ENSP000003411084STRING: ENSP00000341108 I2D: score=1 
    HMX3A6NHT53, ENSP000003505494STRING: ENSP00000350549 I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--

    USP38 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP38 (UBP38)

    1 HMDB Compound for USP38    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about USP38 / UBP38

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP38 gene: 
    NM_032557.5  

    Unigene Cluster for USP38:

    Ubiquitin specific peptidase 38
    Hs.480848  [show with all ESTs]
    Unigene Representative Sequence: NM_032557
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510377(uc003ija.4) ENST00000307017(uc003ijb.3 uc003ijc.3)
    ENST00000511739
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP38
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate USP38 (see all 31):
    hsa-miR-217 hsa-miR-875-3p hsa-miR-125a-5p hsa-miR-137 hsa-let-7d hsa-miR-509-5p hsa-miR-1278 hsa-let-7c
    SwitchGear 3'UTR luciferase reporter plasmidUSP38 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for USP38
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP38
    Clone
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    OriGene ORF clones in mouse, rat for USP38
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP38 (NM_032557)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP38
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP38
    Sirion Biotech Customized lentivirus for stable overexpression of USP38 
                         Customized lentivirus expression plasmids for stable overexpression of USP38 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for USP38
    OriGene qSTAR qPCR primer pairs in human, mouse for USP38
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP38
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP38
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP38

    Additional mRNA sequence: 

    AB067478.1 AF211481.1 AK057992.1 AK091712.1 AK093289.1 AK093754.1 AK126943.1 AL833976.1 
    BC017668.2 BC039115.1 BC068975.1 

    12 DOTS entries:

    DT.99984634  DT.443246  DT.97827058  DT.100815561  DT.99937617  DT.100815558  DT.95090603  DT.121245871 
    DT.75161200  DT.99940200  DT.100815559  DT.91945005 

    24/164 AceView cDNA sequences (see all 164):

    F08122 BM452222 CR619187 Z45502 BC017668 AA476948 AK126943 AI863678 
    AB067478 AA830370 NM_032557 AW452524 AA262265 AK093289 BF033560 AA284365 
    CA393804 AW197132 CB132888 AX748288 F04367 BM053004 AI033130 Z41195 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP38 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    USP38 Expression
    About this image


    See USP38 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP38

    SOURCE GeneReport for Unigene cluster: Hs.480848

    UniProtKB/Swiss-Prot: UBP38_HUMAN, Q8NB14
    Tissue specificity: Highly expressed in skeletal muscle. Expressed in adrenal gland

        SABiosciences Custom PCR Arrays for USP38
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP38

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP38 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp381 , 5 ubiquitin specific peptidase 381, 5 87.46(n)1
    90.12(a)1
      8 (38.68 cM)5
    748411  NM_027554.21  NP_081830.21 
     809807345 
    chicken
    (Gallus gallus)
    Aves USP381 ubiquitin specific peptidase 38 74.17(n)
    75.53(a)
      422455  XM_420421.3  XP_420421.3 
    lizard
    (Anolis carolinensis)
    Reptilia USP386
    ubiquitin specific peptidase 38
    71(a)
    1 ↔ 1
    5(118707144-118726822)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.101042 Transcribed sequence with weak similarity to protein refNP_115946.1 (H.sapiens) HP43.8KD protein; KIAA1891 protein [Homo sapiens] less 79.73(n)    142003899 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.153832 Transcribed sequence with weak similarity to protein spO75317 (H.sapiens) UBPC_HUMAN Ubiquitin carboxyl-terminal hydrolase 12 (Ubiquitin thiolesterase 12) (Ubiquitin-specific processing protease 12) (Deubiquitinating enzyme 12) (Ubiquitin hydrolyzing en less 74.25(n)    57060514 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG88306
    --
    29(a)
    1 → many
    2R(8319407-8324082)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP136
    UBP96
    Putative ubiquitin carboxyl-terminal hydrolase, ub...
    Ubiquitin carboxyl-terminal hydrolase, ubiquitin-s...
    15(a)
    14(a)
    many ↔ many
    many ↔ many
    II(93639-95882)
    V(355466-357730)


    ENSEMBL Gene Tree for USP38 (if available)
    TreeFam Gene Tree for USP38 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP38 gene
    USP352  USP122  USP462  USP12  
    3 SIMAP similar genes for USP38 using alignment to 3 protein entries:     UBP38_HUMAN (see all proteins):
    C4orf21    ZNF212    USP35

    USP38 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/716 SNPs in USP38 are shown (see all 716)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs126406981,2
    C,F,A,H--144104094(+) TTATAC/TGAAAT 1 -- us2k114Minor allele frequency- T:0.17NA WA CSA EA 378
    rs793935471,2
    C,F--144104651(+) CATTCG/ATCCTG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs757957181,2
    C--144104666(+) TTTCTG/TAGCAC 1 -- us2k10--------
    rs1897737051,2
    --144104714(+) TCCACA/GATCCT 1 -- us2k10--------
    rs111007791,2
    C,F,H--144104764(+) ATTACT/CTTTGT 1 -- us2k116Minor allele frequency- C:0.17NS EA NA WA CSA 781
    rs1431612001,2
    --144104854(+) TAGCAC/TGACTG 1 -- us2k10--------
    rs111007801,2
    C,F,A,H--144104906(+) CCTACA/GAGTCA 1 -- us2k122Minor allele frequency- G:0.35NS EA NA WA CSA 2344
    rs1482064141,2
    --144105315(+) CAACAC/TATACA 1 -- us2k10--------
    rs1411464011,2
    C--144105357(+) TATTTC/TCAAAG 1 -- us2k10--------
    rs1473875531,2
    --144105374(+) TGTATA/GACACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for USP38 (144106070 - 144144983 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for USP38:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv270292CNV Insertion20981092

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing USP38
    DNA2.0 Custom Variant and Variant Library Synthesis for USP38

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for USP38:    About MalaCards
    pancreatic cancer    pancreatitis    breast cancer


    USP38 for disorders           About GeneDecksing

    Genetic Association Database (GAD): USP38

    Export disorders for USP38 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP38 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with USP38)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (2004)
    4. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    5. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2 Nagase T....Ohara O. (2001)
    6. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    7. Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes. (PubMed id 22689415)2 Iphofer A.... Franke R. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84640 HGNC: 20067 AceView: USP38 Ensembl:ENSG00000170185 euGenes: HUgn84640
    ECgene: USP38 H-InvDB: USP38

    (According to HUGE)
    About This Section
    HUGE: KIAA1891

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP38 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP38 gene:
    Search GeneIP for patents involving USP38

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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