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Aliases for USP38 Gene

Aliases for USP38 Gene

  • Ubiquitin Specific Peptidase 38 2 3 5
  • Ubiquitin-Specific-Processing Protease 38 3 4
  • Ubiquitin Specific Protease 38 2 3
  • Deubiquitinating Enzyme 38 3 4
  • Ubiquitin Thioesterase 38 3 4
  • HP43.8KD 3 4
  • Ubiquitin Thiolesterase 38 3
  • EC 4
  • KIAA1891 4

External Ids for USP38 Gene

Previous GeneCards Identifiers for USP38 Gene

  • GC04P144572
  • GC04P144683
  • GC04P144463
  • GC04P144325
  • GC04P144106
  • GC04P139835

Summaries for USP38 Gene

GeneCards Summary for USP38 Gene

USP38 (Ubiquitin Specific Peptidase 38) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway and Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP35.

UniProtKB/Swiss-Prot for USP38 Gene

  • Deubiquitinating enzyme exhibiting a preference towards Lys-63-linked Ubiquitin chains.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP38 Gene

Genomics for USP38 Gene

Regulatory Elements for USP38 Gene

Enhancers for USP38 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around USP38 on UCSC Golden Path with GeneCards custom track

Promoters for USP38 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around USP38 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP38 Gene

143,184,917 bp from pter
143,223,874 bp from pter
38,958 bases
Plus strand

Genomic View for USP38 Gene

Genes around USP38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP38 Gene

Proteins for USP38 Gene

  • Protein details for USP38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 38
    Protein Accession:
    Secondary Accessions:
    • B3KX93
    • Q3ZCV1
    • Q8NDF5
    • Q96DK6
    • Q96PZ6
    • Q9BY55

    Protein attributes for USP38 Gene

    1042 amino acids
    Molecular mass:
    116546 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK26248.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71627.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03730.1; Type=Miscellaneous discrepancy; Note=The absence of the residues from Tyr-840 to Ser-871 is not the result of an alternative splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for USP38 Gene

    Alternative splice isoforms for USP38 Gene


neXtProt entry for USP38 Gene

Proteomics data for USP38 Gene at MOPED

Post-translational modifications for USP38 Gene

  • Ubiquitination at Lys 773
  • Modification sites at PhosphoSitePlus

Other Protein References for USP38 Gene

No data available for DME Specific Peptides for USP38 Gene

Domains & Families for USP38 Gene

Gene Families for USP38 Gene

Protein Domains for USP38 Gene

Suggested Antigen Peptide Sequences for USP38 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP38: view

Function for USP38 Gene

Molecular function for USP38 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme exhibiting a preference towards Lys-63-linked Ubiquitin chains.

Enzyme Numbers (IUBMB) for USP38 Gene

genes like me logo Genes that share phenotypes with USP38: view

Animal Models for USP38 Gene

MGI Knock Outs for USP38:

Animal Model Products

  • Taconic Biosciences Mouse Models for USP38

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP38 Gene

Localization for USP38 Gene

Subcellular locations from

Jensen Localization Image for USP38 Gene COMPARTMENTS Subcellular localization image for USP38 gene
Compartment Confidence
cytosol 3
nucleus 3
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP38 Gene

Pathways & Interactions for USP38 Gene

genes like me logo Genes that share pathways with USP38: view

Pathways by source for USP38 Gene

1 BioSystems pathway for USP38 Gene
1 Qiagen pathway for USP38 Gene

Gene Ontology (GO) - Biological Process for USP38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with USP38: view

No data available for SIGNOR curated interactions for USP38 Gene

Drugs & Compounds for USP38 Gene

(1) Additional Compounds for USP38 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with USP38: view

Transcripts for USP38 Gene

Unigene Clusters for USP38 Gene

Ubiquitin specific peptidase 38:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP38 Gene

No ASD Table

Relevant External Links for USP38 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP38 Gene

mRNA expression in normal human tissues for USP38 Gene

mRNA differential expression in normal tissues according to GTEx for USP38 Gene

This gene is overexpressed in Muscle - Skeletal (x6.8).

Protein differential expression in normal tissues from HIPED for USP38 Gene

This gene is overexpressed in Tlymphocyte (67.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP38 Gene

SOURCE GeneReport for Unigene cluster for USP38 Gene Hs.480848

mRNA Expression by UniProt/SwissProt for USP38 Gene

Tissue specificity: Highly expressed in skeletal muscle. Expressed in adrenal gland.
genes like me logo Genes that share expression patterns with USP38: view

Protein tissue co-expression partners for USP38 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for USP38 Gene

Orthologs for USP38 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP38 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia USP38 35
  • 91.09 (n)
  • 92.88 (a)
USP38 36
  • 93 (a)
(Canis familiaris)
Mammalia USP38 35
  • 90.1 (n)
  • 90.26 (a)
USP38 36
  • 90 (a)
(Mus musculus)
Mammalia Usp38 35
  • 87.46 (n)
  • 90.12 (a)
Usp38 16
Usp38 36
  • 90 (a)
(Pan troglodytes)
Mammalia USP38 35
  • 99.46 (n)
  • 99.62 (a)
USP38 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Usp38 35
  • 87.16 (n)
  • 89.63 (a)
(Monodelphis domestica)
Mammalia USP38 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia USP38 36
  • 81 (a)
(Gallus gallus)
Aves USP38 35
  • 73.82 (n)
  • 75.24 (a)
USP38 36
  • 75 (a)
(Anolis carolinensis)
Reptilia USP38 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10104 35
usp38 35
  • 70.6 (n)
  • 75.61 (a)
(Danio rerio)
Actinopterygii Dr.15383 35
usp38 35
  • 63.82 (n)
  • 67.61 (a)
USP38 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8830 36
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP13 36
  • 18 (a)
UBP9 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
Species with no ortholog for USP38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP38 Gene

Gene Tree for USP38 (if available)
Gene Tree for USP38 (if available)

Paralogs for USP38 Gene

Paralogs for USP38 Gene

(3) SIMAP similar genes for USP38 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with USP38: view

Variants for USP38 Gene

Sequence variations from dbSNP and Humsavar for USP38 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10598 -- 143,220,798(-) AAATA(A/T)ATTAC utr-variant-3-prime
rs4131029 -- 143,222,425(-) TTAAA(A/G)TATAT utr-variant-3-prime
rs4285045 -- 143,214,565(+) GCCAG(A/G)AATAT reference, synonymous-codon
rs4234886 -- 143,203,339(+) GTTCT(A/G)TTTGT intron-variant
rs4234887 -- 143,213,124(+) GACCA(C/T)TTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP38 Gene

Variant ID Type Subtype PubMed ID
esv270292 CNV Insertion 20981092

Variation tolerance for USP38 Gene

Residual Variation Intolerance Score: 2.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for USP38 Gene

Disorders for USP38 Gene

Relevant External Links for USP38

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for USP38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP38 Gene

Publications for USP38 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates. (PMID: 24811749) Besche H.C. … Goldberg A.L. (EMBO J. 2014) 3
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for USP38 Gene

Sources for USP38 Gene