USP38 Gene
protein-coding GIFtS: 47
GCID: GC04P144106
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ubiquitin specific peptidase 38(Previous name: ubiquitin specific protease 38 )
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Aliases
for USP38 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 381 2 | | Ubiquitin Thioesterase 382 3 | | HP43.8KD1 2 3 | | Ubiquitin-Specific-Processing Protease 382 3 | | Ubiquitin Specific Protease 381 2 | | Ubiquitin Carboxyl-Terminal Hydrolase 382 | | KIAA18911 3 | | Ubiquitin Thiolesterase 382 | | Deubiquitinating Enzyme 382 3 | | EC 3.4.19.123 |
Export aliases for USP38 gene to outside databasesPrevious GC identifers: GC04P144572 GC04P144683 GC04P144463 GC04P144325 GC04P139835 |
Summaries
for USP38 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UBP38_HUMAN, Q8NB14Function: Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked Ubiquitin chains
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Genomic Views
for USP38 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP38 gene promoter:
Meis-1b E47 GATA-1 C/EBPalpha Max Egr-2 AREB6 Zic1 Meis-1a c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP38
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP38 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Ensembl cytogenetic band: 4q31.21 HGNC cytogenetic band: 4q31.1USP38 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P144106: view genomic region
(about GC identifiers)
Start:
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144,106,070 bp from pter |
End:
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144,144,983 bp from pter |
Size:
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38,914 bases |
Orientation:
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plus strand |
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Proteins
for USP38 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP38_HUMAN, Q8NB14 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 38 Size: 1042 amino acids; 116546 Da
Sequence caution: Sequence=AAK26248.1; Type=Erroneous initiation; Sequence=BAB71627.1; Type=Erroneous initiation;Sequence=BAC03730.1; Type=Miscellaneous discrepancy; Note=The absence of the residues from Tyr-840 to Ser-871 is notthe result of an alternative splicing;
Secondary accessions: B3KX93 Q8NDF5 Q96DK6 Q96PZ6 Q9BY55Explore the universe of human proteins at neXtProt for USP38: NX_Q8NB14
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NB14
USP38 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115946.2
ENSEMBL proteins: ENSP00000427647 ENSP00000303434 ENSP00000424158
Human Recombinant Protein Products:
USP38 Antibody Products:
Assay Products for USP38: |
Protein
Domains /
Families
for USP38 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP38 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NB14ProtoNet protein and cluster: Q8NB14 1 Blocks protein family: IPB001394 Ubiquitin thiolesterase
UniProtKB/Swiss-Prot: UBP38_HUMAN, Q8NB14Similarity: Belongs to the peptidase C19 family |
Function
for USP38 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBP38_HUMAN, Q8NB14Function: Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked Ubiquitin chainsCatalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)Enzyme Number (IUBMB): EC 3.4.19.121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP38 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP38
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: USP38 (NM_032557) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP38 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP38 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP38 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004221 | ubiquitin thiolesterase activity |
IEA | -- | | GO:0008234 | cysteine-type peptidase activity |
IEA | -- |
USP38 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for USP38:
|
Pathways & Interactions
for USP38 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitin-Proteasome Dependent Proteolysis | | | 2 | Integrated Breast Cancer Pathway | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP38
1  BioSystems Pathway for USP38
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP38
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/10 Interacting proteins for USP38 (Q8NB143 ENSP000003034344) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- |
USP38 for ontologies About GeneDecksing
|
Drugs & Compounds
for USP38 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USP38
1 HMDB Compound for USP38 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Water | Dihydrogen oxide (see all 2) | 7732-18-5 | -- |
Search CenterWatch for drugs/clinical trials and news about USP38 / UBP38
|
Transcripts
for USP38 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP38 gene: NM_032557.5 Unigene Cluster for USP38: Ubiquitin specific peptidase 38 Hs.480848 [show with all ESTs]Unigene Representative Sequence: NM_0325573 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000510377(uc003ija.4) ENST00000307017(uc003ijb.3 uc003ijc.3)
ENST00000511739
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP38 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP38
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: USP38 (NM_032557) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP38 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP38 |
Additional cDNA sequence: AB067478.1 AF211481.1 AK057992.1 AK091712.1 AK093289.1 AK093754.1 AK126943.1 AL833976.1 BC017668.2 BC039115.1 BC068975.1 12 DOTS entries: DT.99984634 DT.443246 DT.97827058 DT.100815561 DT.99937617 DT.100815558 DT.95090603 DT.121245871 DT.75161200 DT.99940200 DT.100815559 DT.91945005 24/164 AceView cDNA sequences (see all 164): NM_032557 AW452524 Z45502 BC017668 BC068975 AA476948 CB132888 AA262265 AK093289 AW197132 BM053004 CA393804 BG575871 BF913945 CR619187 BF033560 AL833976 BX396124 AW571778 AA284365 BX488016 F08122 AK093754 BM452222
GeneLoc Exon Structure
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Expression
for USP38 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP38 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See USP38 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP38
SOURCE GeneReport for Unigene cluster: Hs.480848
UniProtKB/Swiss-Prot: UBP38_HUMAN, Q8NB14Tissue specificity: Highly expressed in skeletal muscle. Expressed in adrenal gland
SABiosciences Custom PCR Arrays for USP38
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP38
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP38 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP38 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP38 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP38 |
Orthologs
for USP38 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for USP38 gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for USP38 (if available)
TreeFam Gene Tree for USP38 (if available) |
Paralogs
for USP38 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP38 gene
- USP352 USP122 USP462 USP12
3 SIMAP similar genes for USP38 using alignment to 3 protein entries: UBP38_HUMAN (see all proteins):C4orf21 ZNF212 USP35
USP38 for paralogs About GeneDecksing
|
Genomic Variants
for USP38 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP38 |
|
Disorders
/ Diseases
for USP38 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP38 for disorders About GeneDecksing
2  diseases for USP38: About MalaCardspancreatic cancer pancreatitis
Export disorders for USP38 gene to outside databases
|
Publications
for USP38 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USP38 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with USP38) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (2004)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2 Nagase T....Ohara O. (2001)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
- Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes. (PubMed id 22689415)2 Iphofer A.... Franke R. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for USP38 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing USP38 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USP38 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing USP38 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for USP38 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for USP38 gene:
Search GeneIP for patents involving USP38
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for USP38 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for USP38 | | OriGene shRNA RFP for USP38 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP38 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP38 | | | OriGene Protein Over-expression Lysate for USP38 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for USP38 | | OriGene 3'-UTR Clone for USP38 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP38 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP38 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for USP38 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for USP38 | | OriGene Custom Protein Services for USP38 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP38 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP38 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP38 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP38 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP38 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP38 |
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| | | | Search Tocris compounds for USP38 |
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 | | | USP38 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP38 |
|  |  |  | | | | Search ThermoFisher Antibodies for USP38 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP38 |
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