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Aliases for USP37 Gene

Aliases for USP37 Gene

  • Ubiquitin Specific Peptidase 37 2 3 5
  • Ubiquitin-Specific-Processing Protease 37 3 4
  • Ubiquitin Specific Protease 37 2 3
  • Deubiquitinating Enzyme 37 3 4
  • Ubiquitin Thioesterase 37 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 37 3
  • Ubiquitin Thiolesterase 37 3
  • Tmp_locus_50 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 58
  • KIAA1594 4

External Ids for USP37 Gene

Previous GeneCards Identifiers for USP37 Gene

  • GC02M219281
  • GC02M219517
  • GC02M219140
  • GC02M219023
  • GC02M211167

Summaries for USP37 Gene

GeneCards Summary for USP37 Gene

USP37 (Ubiquitin Specific Peptidase 37) is a Protein Coding gene. Among its related pathways are Deubiquitination and Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include protein kinase binding and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP29.

UniProtKB/Swiss-Prot for USP37 Gene

  • Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of Lys-11-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of Lys-48-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872).

Gene Wiki entry for USP37 Gene

Additional gene information for USP37 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP37 Gene

Genomics for USP37 Gene

Regulatory Elements for USP37 Gene

Enhancers for USP37 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H218269 1.4 ENCODE dbSUPER 31.1 +295.7 295727 7 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ENSG00000261338 USP37 NHEJ1 AAMP ARPC2 CNOT9 PNKD TMBIM1 MIR6513
GH02H218566 1.8 FANTOM5 ENCODE dbSUPER 22.9 -1.0 -952 4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B AAMP CNOT9 USP37 PLCD4 BCS1L NHEJ1 CNPPD1 SLC23A3 ZNF142 RNF25
GH02H218393 2.1 FANTOM5 Ensembl ENCODE dbSUPER 19 +167.4 167360 14 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 CNOT9 AAMP USP37 STK36 ANKZF1 TNS1 BCS1L ENSG00000273466 NHEJ1 TMBIM1
GH02H218908 2 FANTOM5 Ensembl ENCODE dbSUPER 18.1 -341.2 -341233 2 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B CNOT9 STK36 ZNF142 USP37 AAMP OBSL1 NHEJ1 ENSG00000235024 CDK5R2 ENSG00000269068
GH02H217845 1.8 FANTOM5 Ensembl ENCODE dbSUPER 19.8 +715.6 715604 15 ZSCAN4 KLF17 FOS RCOR1 EGR2 MCM3 ZNF398 ZFP69B NFIC GLIS1 USP37 TNS1 AAMP LOC105373878 BCS1L CNOT9 PLCD4 PNKD ARPC2 GC02P217871
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around USP37 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP37 Gene

Chromosome:
2
Start:
218,450,251 bp from pter
End:
218,568,366 bp from pter
Size:
118,116 bases
Orientation:
Minus strand

Genomic View for USP37 Gene

Genes around USP37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP37 Gene

Proteins for USP37 Gene

  • Protein details for USP37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T82-UBP37_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 37
    Protein Accession:
    Q86T82
    Secondary Accessions:
    • A2RUQ8
    • B7ZM38
    • B7ZM41
    • E9PHL3
    • Q2KHT2
    • Q53S10
    • Q7Z3A5
    • Q9HCH8

    Protein attributes for USP37 Gene

    Size:
    979 amino acids
    Molecular mass:
    110170 Da
    Quaternary structure:
    • Interacts with FZR1/CDH1 (PubMed:21596315). Interacts with CDT1 (PubMed:27296872).
    SequenceCaution:
    • Sequence=AAY14887.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for USP37 Gene

    Alternative splice isoforms for USP37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP37 Gene

Selected DME Specific Peptides for USP37 Gene

Q86T82:
  • NLGNTCYMN
  • GHYISDV

Post-translational modifications for USP37 Gene

  • Phosphorylated at Ser-628 by CDK2 during G1/S phase but not during mitosis; phosphorylation at Ser-628 is required for deubiquitinase activity. Also polyubiquitinated during early G1 phase, without leading to degradation.
  • Polyubiquitinated via Lys-11-linked ubiquitin by the APC(CDH1) complex during late mitosis, leading to its degradation. Able to mediate auto-deubiquitination.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for USP37 Gene

Gene Families for USP37 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for USP37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86T82

UniProtKB/Swiss-Prot:

UBP37_HUMAN :
  • The KEN box 3 is required for interaction with FZR1/CDH1 and is essential for APC(CDH1)-mediated ubiquitination.
  • Belongs to the peptidase C19 family.
Domain:
  • The KEN box 3 is required for interaction with FZR1/CDH1 and is essential for APC(CDH1)-mediated ubiquitination.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP37: view

Function for USP37 Gene

Molecular function for USP37 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of Lys-11-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of Lys-48-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872).
UniProtKB/Swiss-Prot Induction:
Induced by E2F transcription factors in G1.

Enzyme Numbers (IUBMB) for USP37 Gene

Phenotypes From GWAS Catalog for USP37 Gene

Gene Ontology (GO) - Molecular Function for USP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IDA 21596315
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 14715245
GO:0005515 protein binding IPI 21596315
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP37: view
genes like me logo Genes that share phenotypes with USP37: view

Animal Model Products

  • Taconic Biosciences Mouse Models for USP37

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for USP37
  • Applied Biological Materials Clones for USP37
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP37 Gene

Localization for USP37 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP37 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for USP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with USP37: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for USP37 Gene

Pathways & Interactions for USP37 Gene

genes like me logo Genes that share pathways with USP37: view

Pathways by source for USP37 Gene

Gene Ontology (GO) - Biological Process for USP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 21596315
GO:0006275 regulation of DNA replication IMP 27296872
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with USP37: view

No data available for SIGNOR curated interactions for USP37 Gene

Drugs & Compounds for USP37 Gene

(1) Drugs for USP37 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with USP37: view

Transcripts for USP37 Gene

Unigene Clusters for USP37 Gene

Ubiquitin specific peptidase 37:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for USP37
  • Applied Biological Materials Clones for USP37
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for USP37 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a ·
SP1: - - - -
SP2: - - -
SP3: -
SP4:
SP5:

ExUns: 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for USP37 Gene

GeneLoc Exon Structure for
USP37
ECgene alternative splicing isoforms for
USP37

Expression for USP37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP37 Gene

This gene is overexpressed in Testis (x4.1).

Protein differential expression in normal tissues from HIPED for USP37 Gene

This gene is overexpressed in Heart (63.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for USP37 Gene



Protein tissue co-expression partners for USP37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of USP37 Gene:

USP37

SOURCE GeneReport for Unigene cluster for USP37 Gene:

Hs.166068

mRNA Expression by UniProt/SwissProt for USP37 Gene:

Q86T82-UBP37_HUMAN
Tissue specificity: Expressed in brain and prostate.

Evidence on tissue expression from TISSUES for USP37 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with USP37: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for USP37 Gene

Orthologs for USP37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for USP37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP37 33 34
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia USP37 33 34
  • 93.8 (n)
cow
(Bos Taurus)
Mammalia USP37 33 34
  • 93.5 (n)
rat
(Rattus norvegicus)
Mammalia Usp37 33
  • 89.49 (n)
mouse
(Mus musculus)
Mammalia Usp37 33 16 34
  • 88.74 (n)
oppossum
(Monodelphis domestica)
Mammalia USP37 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP37 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP37 33 34
  • 75.04 (n)
lizard
(Anolis carolinensis)
Reptilia USP37 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp37 33
  • 66.39 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32185 33
zebrafish
(Danio rerio)
Actinopterygii usp37 33 34
  • 61.66 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9946 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2829 34
  • 29 (a)
OneToMany
Species where no ortholog for USP37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP37 Gene

ENSEMBL:
Gene Tree for USP37 (if available)
TreeFam:
Gene Tree for USP37 (if available)

Paralogs for USP37 Gene

Paralogs for USP37 Gene

(2) SIMAP similar genes for USP37 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for USP37 Gene

genes like me logo Genes that share paralogs with USP37: view

Variants for USP37 Gene

Sequence variations from dbSNP and Humsavar for USP37 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000005302 -- 218,546,152(+) TCTTC(C/T)CCAGT intron-variant
rs1000008154 -- 218,525,480(+) CCCTG(C/T)CTAAA intron-variant
rs1000079946 -- 218,569,737(+) ATGCA(C/G)TTTGT intron-variant, upstream-variant-2KB
rs1000113053 -- 218,565,814(+) GAGGC(C/T)GAGGC intron-variant
rs1000113412 -- 218,554,151(+) TAATG(C/T)GTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP37 Gene

Variant ID Type Subtype PubMed ID
esv1137385 CNV insertion 17803354
esv2518247 CNV insertion 19546169
esv3594341 CNV loss 21293372
esv3594342 CNV loss 21293372
nsv1127800 CNV deletion 24896259
nsv1131549 CNV deletion 24896259
nsv3167 CNV insertion 18451855
nsv3168 CNV deletion 18451855
nsv508199 CNV deletion 20534489

Variation tolerance for USP37 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP37 Gene

Disorders for USP37 Gene

Relevant External Links for USP37

Genetic Association Database (GAD)
USP37
Human Genome Epidemiology (HuGE) Navigator
USP37
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP37

No disorders were found for USP37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP37 Gene

Publications for USP37 Gene

  1. USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication. (PMID: 27296872) Hernández-Pérez S … Freire R (Molecular oncology 2016) 3 4 60
  2. Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. (PMID: 21596315) Huang X … Dixit VM (Molecular cell 2011) 3 4 60
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 45 60
  4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 45 60
  5. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V … López-Otín C (Biochemical and biophysical research communications 2004) 3 4 60

Products for USP37 Gene

  • Addgene plasmids for USP37

Sources for USP37 Gene

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