USP37 Gene
protein-coding GIFtS: 51
GCID: GC02M219281
|
|
ubiquitin specific peptidase 37(Previous name: ubiquitin specific protease 37 )
| |
Aliases
for USP37 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 371 2 | | Tmp_locus_501 | | Ubiquitin Specific Protease 371 2 | | Ubiquitin Carboxyl-Terminal Hydrolase 372 | | KIAA15941 3 | | Ubiquitin Thiolesterase 372 | | Deubiquitinating Enzyme 372 3 | | EC 3.4.19.123 | | Ubiquitin Thioesterase 372 3 | | EC 3.1.2.158 | | Ubiquitin-Specific-Processing Protease 372 3 | | |
Export aliases for USP37 gene to outside databasesPrevious GC identifers: GC02M219517 GC02M219140 GC02M219023 GC02M211167 |
Summaries
for USP37 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UBP37_HUMAN, Q86T82Function: Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediatingdeubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediatesdeubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/Ccomplex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2)
Gene Wiki entry for USP37
|
Genomic Views
for USP37 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP37 gene promoter:
SRF SRF (504 AA) HNF-3beta C/EBPalpha Evi-1 CHOP-10 E2F-1 E2F Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP37
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP37 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35USP37 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M219281: view genomic region
(about GC identifiers)
Start:
|
219,314,974 bp from pter |
End:
|
219,433,084 bp from pter |
Size:
|
118,111 bases |
Orientation:
|
minus strand |
|
Proteins
for USP37 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP37_HUMAN, Q86T82 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 37 Size: 979 amino acids; 110170 Da
Subunit: Interacts with FZR1/CDH1
Developmental stage: Induced in G1 phase, accumulates at G1/S transition, and degraded in late mitosis followingubiquitination and degradation by the APC(CDH1) complex
Sequence caution: Sequence=AAY14887.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from  and Proteopedia  for USP37:3U12 (3D)
Secondary accessions: A2RUQ8 B7ZM38 B7ZM41 E9PHL3 Q2KHT2 Q53S10 Q7Z3A5 Q9HCH8Alternative splicing: 2 isoforms: Q86T82-1 Q86T82-2 Explore the universe of human proteins at neXtProt for USP37: NX_Q86T82
Post-translational modifications:
Polyubiquitinated via 'Lys-11'-linked ubiquitin by the APC(CDH1) complex during late mitosis, leading to itsdegradation. Able to mediate auto-deubiquitination1
Phosphorylated at Ser-628 by CDK2 during G1/S phase but not during mitosis; phosphorylation at Ser-628 is required fordeubiquitinase activity. Also polyubiquitinated during early G1 phase, without leading to degradation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86T82
2 DME Specific Peptides for USP37 (Q86T82)
USP37 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065986.2
ENSEMBL proteins: ENSP00000258399 ENSP00000393662 ENSP00000400902 ENSP00000396585 ENSP00000345043
Human Recombinant Protein Products for USP37:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IDA | -- |
USP37 for ontologies About GeneDecksing
USP37 Antibody Products:
Assay Products for USP37: |
Protein
Domains /
Families
for USP37 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP37 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86T82ProtoNet protein and cluster: Q86T82 2 Blocks protein families: IPB001394 Ubiquitin thiolesterase IPB003903 Ubiquitin interacting motif
UniProtKB/Swiss-Prot: UBP37_HUMAN, Q86T82Domain: The KEN box 3 is required for interaction with FZR1/CDH1 and is essential for APC(CDH1)-mediated ubiquitinationSimilarity: Belongs to the peptidase C19 familySimilarity: Contains 3 UIM (ubiquitin-interacting motif) repeats |
Function
for USP37 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: UBP37_HUMAN, Q86T82Function: Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediatingdeubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediatesdeubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/Ccomplex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2)Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)Induction: Induced by E2F transcription factors in G1 Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004197 | cysteine-type endopeptidase activity |
IDA | -- | | GO:0004221 | ubiquitin thiolesterase activity |
IEA | -- | | GO:0004843 | ubiquitin-specific protease activity |
IDA | -- | | GO:0005515 | protein binding |
IPI | -- | | GO:0019901 | protein kinase binding |
IPI | -- |
USP37 for ontologies About GeneDecksing
Phenotypes:
4 GenomeRNAi human phenotypes for USP37:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP37 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP37
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: USP37 (NM_020935) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP37 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP37 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP37 |
|
Pathways & Interactions
for USP37 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitin-Proteasome Dependent Proteolysis | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP37
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP37
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for USP37 (Q86T823 ENSP000002583994) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000082 | G1/S transition of mitotic cell cycle |
IDA | -- | | GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- | | GO:0007067 | mitosis |
IEA | -- | | GO:0035871 | protein K11-linked deubiquitination |
IDA | -- | | GO:0051301 | cell division |
IEA | -- |
USP37 for ontologies About GeneDecksing
|
Drugs & Compounds
for USP37 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USP37
1 HMDB Compound for USP37 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Water | Dihydrogen oxide (see all 2) | 7732-18-5 | -- |
Search CenterWatch for drugs/clinical trials and news about USP37 / UBP37
|
Transcripts
for USP37 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP37 gene: NM_020935.2 Unigene Cluster for USP37: Ubiquitin specific peptidase 37 Hs.166068 [show with all ESTs]Unigene Representative Sequence: NM_02093511 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000258399(uc010fvs.1 uc002vie.2 uc010zkf.1 uc002vif.2 uc002vig.2)
ENST00000454775 ENST00000415516 ENST00000418019 ENST00000473554 ENST00000484018
ENST00000475553 ENST00000466523 ENST00000486242 ENST00000478329 ENST00000338465(uc010zkg.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP37 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP37
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: USP37 (NM_020935) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP37 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP37 |
Additional cDNA sequence: AB046814.1 AK095577.1 AK128583.1 AL832645.2 BC037389.1 BC050461.1 BC112901.1 BC133007.1 BC133009.1 BC144249.1 BC144252.1 BX538024.1 11 DOTS entries: DT.416827 DT.101982046 DT.100774479 DT.120989531 DT.120989519 DT.120989544 DT.120989507 DT.432427 DT.91847689 DT.92056577 DT.99972371 24/110 AceView cDNA sequences (see all 110): BX116157 CA777132 AA831500 F01458 BM462937 BM674600 AB046814 BU634389 W02953 AI247514 BU521253 BU521300 AW026318 BE670098 AI911988 Z40302 AI419935 AW196356 AI632367 AI609777 BX538024 AA813301 BC037389 CD641602
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for USP37 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24a | · |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 24b | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 |
|---|
|
| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for USP37
|
Expression
for USP37 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP37 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See USP37 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP37
SOURCE GeneReport for Unigene cluster: Hs.166068
UniProtKB/Swiss-Prot: UBP37_HUMAN, Q86T82Tissue specificity: Expressed in brain and prostate
SABiosciences Custom PCR Arrays for USP37
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP37
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP37 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP37 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP37 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP37 |
Orthologs
for USP37 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for USP37 gene from 4/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
USP371 |
ubiquitin specific peptidase 37 |
75.04(n)
78.46(a) |
|
424216 XM_422065.3 XP_422065.3 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
71(a) |
1 → many |
1(88475056-88503520) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.321852 |
Xenopus laevis transcribed sequence with weak similarity more |
71.22(n) |
|
48045346 |
zebrafish
(Danio rerio) |
Actinopterygii |
AL915806.12 |
-- |
75.22(n) |
|
AL915806.1 |
ENSEMBL Gene Tree for USP37 (if available)
TreeFam Gene Tree for USP37 (if available) |
Paralogs
for USP37 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP37 gene
- USP262 USP292
2 SIMAP similar genes for USP37 using alignment to 2 protein entries: UBP37_HUMAN (see all proteins):USP26 USP29
USP37 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for USP37
PGOHUM00000241450
|
Genomic Variants
for USP37 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP37 (219314974 - 219433084 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for USP37
1 Indel: 98138 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP37 |
|
Disorders
/ Diseases
for USP37 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP37 for disorders About GeneDecksing
1  disease for USP37: About MalaCardsprostatitis
Human Genome Epidemiology (HuGE) Navigator: USP37 (2 documents)
Export disorders for USP37 gene to outside databases
|
Publications
for USP37 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USP37 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with USP37) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. (PubMed id 21596315)1, 2 Huang X.... Dixit V.M. (2011)
- Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (2004)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
- Skp1-Cul1-F-box ubiquitin ligase (SCF(bTrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes m itotic entry. (PubMed id 23027877)1 Burrows A.C....Summers M.K. (2012)
- Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (2010)
- Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1 Yoshida T....Yamada Y. (2010)
|
External Searches for USP37 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing USP37 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USP37 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing USP37 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for USP37 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for USP37 gene:
Search GeneIP for patents involving USP37
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for USP37 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP37 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP37 | | | OriGene Protein Over-expression Lysate for USP37 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for USP37 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP37 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP37 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for USP37 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for USP37 | | OriGene Custom Protein Services for USP37 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP37 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP37 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP37 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP37 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP37 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP37 |
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| | | | Search Tocris compounds for USP37 |
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 | | | USP37 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP37 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for USP37 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP37 |
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