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USP37 Gene

protein-coding   GIFtS: 55
GCID: GC02M219281

Ubiquitin Specific Peptidase 37

(Previous name: ubiquitin specific protease 37)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 371 2     Ubiquitin Carboxyl-Terminal Hydrolase 372
Ubiquitin Specific Protease 371 2     Ubiquitin Thiolesterase 372
Deubiquitinating Enzyme 372 3     EC 3.4.19.123
Ubiquitin Thioesterase 372 3     KIAA15943
Ubiquitin-Specific-Processing Protease 372 3     EC 3.1.2.158
tmp_locus_502     

External Ids:    HGNC: 200631   Entrez Gene: 576952   Ensembl: ENSG000001359137   UniProtKB: Q86T823   

Export aliases for USP37 gene to outside databases

Previous GC identifers: GC02M219517 GC02M219140 GC02M219023 GC02M211167


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for USP37 Gene:
USP37 (ubiquitin specific peptidase 37) is a protein-coding gene. GO annotations related to this gene include cysteine-type endopeptidase activity and protein kinase binding. An important paralog of this gene is USP26.

UniProtKB/Swiss-Prot: UBP37_HUMAN, Q86T82
Function: Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by
mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates
deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C
complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at
Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A
(CCNA1 and CCNA2)

Gene Wiki entry for USP37 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP37 gene promoter:
         SRF   SRF (504 AA)   HNF-3beta   C/EBPalpha   Evi-1   CHOP-10   E2F-1   E2F   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP37 promoter sequence
   Search Chromatin IP Primers for USP37

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

USP37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP37 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M219281:  view genomic region     (about GC identifiers)

Start:
219,314,974 bp from pter      End:
219,433,084 bp from pter
Size:
118,111 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBP37_HUMAN, Q86T82 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 37  
Size: 979 amino acids; 110170 Da
Subunit: Interacts with FZR1/CDH1
Developmental stage: Induced in G1 phase, accumulates at G1/S transition, and degraded in late mitosis following
ubiquitination and degradation by the APC(CDH1) complex
Sequence caution: Sequence=AAY14887.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for USP37:
3U12 (3D)    
Secondary accessions: A2RUQ8 B7ZM38 B7ZM41 E9PHL3 Q2KHT2 Q53S10 Q7Z3A5 Q9HCH8
Alternative splicing: 2 isoforms:  Q86T82-1   Q86T82-2   

Explore the universe of human proteins at neXtProt for USP37: NX_Q86T82

Explore proteomics data for USP37 at MOPED

Post-translational modifications: 

  • Polyubiquitinated via 'Lys-11'-linked ubiquitin by the APC(CDH1) complex during late mitosis, leading to its
    degradation. Able to mediate auto-deubiquitination1
  • Phosphorylated at Ser-628 by CDK2 during G1/S phase but not during mitosis; phosphorylation at Ser-628 is required
    for deubiquitinase activity. Also polyubiquitinated during early G1 phase, without leading to degradation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for USP37 (Q86T82)
     GHYISDV  NLGNTCYMN 


    See USP37 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065986.2  
    ENSEMBL proteins: 
     ENSP00000258399   ENSP00000393662   ENSP00000400902   ENSP00000396585   ENSP00000345043  

    USP37 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals USP37 Protein
    Novus Biologicals USP37 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP37

     
    Search eBioscience for Proteins for USP37 

    USP37 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for USP37
    Cloud-Clone Corp. Antibodies for USP37
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    LSBio Antibodies in human, mouse, rat for USP37

    USP37 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for USP37
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP37
    Cloud-Clone Corp. CLIAs for USP37
    Search eBioscience for ELISAs for USP37 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    4 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028889 UCH/PAN2
     IPR003903 Ubiquitin-int_motif

    Graphical View of Domain Structure for InterPro Entry Q86T82

    ProtoNet protein and cluster: Q86T82

    2 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB003903 Ubiquitin interacting motif


    UniProtKB/Swiss-Prot: UBP37_HUMAN, Q86T82
    Domain: The KEN box 3 is required for interaction with FZR1/CDH1 and is essential for APC(CDH1)-mediated
    ubiquitination
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 3 UIM (ubiquitin-interacting motif) repeats
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP37           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP37_HUMAN, Q86T82
    Function: Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by
    mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates
    deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C
    complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at
    Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A
    (CCNA1 and CCNA2)
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Induction: Induced by E2F transcription factors in G1

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IDA--
    GO:0004221ubiquitin thiolesterase activity ----
    GO:0004843ubiquitin-specific protease activity IDA14715245
    GO:0005515protein binding IPI--
    GO:0019901protein kinase binding IPI--
         
    Find genes that share ontologies with USP37           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for USP37:
     Increased G2M DNA content  Increased cell size  Increased number of mitotic ce  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP37
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP37
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP37

    miRNA
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    miRTarBase miRNAs that target USP37:
    hsa-mir-30c-5p (MIRT047922), hsa-let-7e-5p (MIRT051589), hsa-mir-19b-3p (MIRT031252)

    Block miRNA regulation of human, mouse, rat USP37 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP37 (see all 100):
    hsa-miR-548j hsa-miR-106a hsa-miR-199a-3p hsa-miR-3138 hsa-miR-30d hsa-miR-3916 hsa-miR-502-3p hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat USP37

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for USP37
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP37 (NM_020935)
    Sino Biological Human cDNA Clone for USP37
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP37
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP37
    Addgene plasmids for USP37 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for USP37 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP37


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    Find genes that share ontologies with USP37           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP37 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP37
        Ubiquitin-Proteasome Dependent Proteolysis



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP37
    Interactions:

        Search GeneGlobe Interaction Network for USP37

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP37 (Q86T823 ENSP000002583994) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT84Q9NSB23, ENSP000002579514I2D: score=2 STRING: ENSP00000257951
    PSMD4P550363, ENSP000003578794I2D: score=1 STRING: ENSP00000357879
    ALBP027683, ENSP000002958974I2D: score=2 STRING: ENSP00000295897
    FBXW11Q9UKB13, ENSP000002650944I2D: score=3 STRING: ENSP00000265094
    YWHAGP619813, ENSP000003063304I2D: score=1 STRING: ENSP00000306330
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IDA--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0007067mitosis IEA--
    GO:0016579protein deubiquitination IDA14715245
    GO:0035871protein K11-linked deubiquitination IDA--

    Find genes that share ontologies with USP37           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP37 (UBP37)

    1 HMDB Compound for USP37    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP37 gene: 
    NM_020935.2  

    Unigene Cluster for USP37:

    Ubiquitin specific peptidase 37
    Hs.166068  [show with all ESTs]
    Unigene Representative Sequence: NM_020935
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258399(uc010fvs.1 uc002vie.2 uc010zkf.1 uc002vif.2 uc002vig.2)
    ENST00000454775 ENST00000415516 ENST00000418019 ENST00000473554 ENST00000484018
    ENST00000475553 ENST00000466523 ENST00000486242 ENST00000478329 ENST00000338465(uc010zkg.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat USP37 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP37 (see all 100):
    hsa-miR-548j hsa-miR-106a hsa-miR-199a-3p hsa-miR-3138 hsa-miR-30d hsa-miR-3916 hsa-miR-502-3p hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Clone
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    OriGene ORF clones in mouse, rat for USP37
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP37 (NM_020935)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP37
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP37
    Addgene plasmids for USP37 
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP37
      QuantiTect SYBR Green Assays in human, mouse, rat USP37
      QuantiFast Probe-based Assays in human, mouse, rat USP37

    Additional mRNA sequence: 

    AB046814.1 AK095577.1 AK128583.1 AL832645.2 BC037389.1 BC050461.1 BC112901.1 BC133007.1 
    BC133009.1 BC144249.1 BC144252.1 BX538024.1 

    11 DOTS entries:

    DT.416827  DT.101982046  DT.100774479  DT.120989531  DT.120989519  DT.120989544  DT.120989507  DT.432427 
    DT.91847689  DT.92056577  DT.99972371 

    Selected AceView cDNA sequences (see all 110):

    BU634389 W02953 AI247514 F01458 CA777132 AA831500 BX116157 BM462937 
    AI609777 BU521300 BU521253 AW026318 AI911988 BE670098 Z40302 AW196356 
    AI419935 AI632367 AB046814 BM674600 BG426468 AK095577 BF940912 BQ937735 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for USP37    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a ·
    SP1:                    -                                               -                                   -                                         -         
    SP2:                                                                    -                                   -                                         -         
    SP3:                    -                                                                                                                                       
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for USP37

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP37 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    USP37 Expression
    About this image


    USP37 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    USP37 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP37 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.166068

    UniProtKB/Swiss-Prot: UBP37_HUMAN, Q86T82
    Tissue specificity: Expressed in brain and prostate

        Custom PCR Arrays for USP37
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    QuantiFast Probe-based Assays in human, mouse, rat USP37
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP37

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for USP37 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp371 , 5 ubiquitin specific peptidase 371, 5 88.74(n)1
    90.79(a)1
      1 (38.54 cM)5
    3196511  NM_176972.41  NP_795946.21 
     744355105 
    chicken
    (Gallus gallus)
    Aves USP371 ubiquitin specific peptidase 37 75.04(n)
    78.46(a)
      424216  XM_422065.4  XP_422065.3 
    lizard
    (Anolis carolinensis)
    Reptilia USP376
    ubiquitin specific peptidase 37
    71(a)
    1 ↔ 1
    1(88475006-88503265)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.321852 Xenopus laevis transcribed sequence with weak similarity more 71.22(n)    48045346 
    zebrafish
    (Danio rerio)
    Actinopterygii AL915806.12   -- 75.22(n)    AL915806.1 


    ENSEMBL Gene Tree for USP37 (if available)
    TreeFam Gene Tree for USP37 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP37 gene
    USP262  USP292  
    2 SIMAP similar genes for USP37 using alignment to 2 protein entries:     UBP37_HUMAN (see all proteins):
    USP26    USP29

    Find genes that share paralogs with USP37           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for USP37
    PGOHUM00000241450


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP37 (see all 2058)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1996321821,2
    C--218733127(+) CAACA-/ACAAACA 1 -- int10--------
    rs1171427091,2
    F--219314883(+) CAGAAA/GGCCAA 1 -- ds50011Minor allele frequency- G:0.01EA 120
    rs1471913881,2
    --219314892(+) AACAGA/GAGGTG 1 -- ds50010--------
    rs11064121,2
    C,F,H--219315057(-) CTTTAC/TGGTTT 1 -- ut3113Minor allele frequency- T:0.12EA NA MN NS WA CSA 1426
    rs1161052061,2
    C,F--219315188(+) GGCCAC/TAGCTG 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs1903733501,2
    --219315442(+) CATCTC/GACTGG 1 -- ut310--------
    rs1406379391,2
    --219315617(+) ACATAC/TAGCAC 1 -- ut310--------
    rs1152876451,2
    C,F--219315733(+) ACAGCA/GAAATA 1 -- ut311Minor allele frequency- G:0.04WA 118
    rs1825664361,2
    --219315885(+) AGTCTA/GTTTAG 1 -- ut310--------
    rs1866925291,2
    --219315960(+) CCATCC/GATTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for USP37 (219314974 - 219433084 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for USP37:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3167CNV Insertion18451855
    esv2518247CNV Insertion19546169
    esv1137385CNV Insertion17803354
    nsv3168CNV Loss18451855
    nsv508199CNV Loss20534489
    nsv875861CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP37
    DNA2.0 Custom Variant and Variant Library Synthesis for USP37

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with USP37           About GenesLikeMe

    Genetic Association Database (GAD): USP37
    Human Genome Epidemiology (HuGE) Navigator: USP37 (2 documents)

    Export disorders for USP37 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP37 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with USP37)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. (PubMed id 21596315)1, 2 Huang X.... Dixit V.M. (Mol. Cell 2011)
    2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    4. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004)
    5. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    6. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    7. Ubiquitin-interacting motifs confer full catalytic activity, but not ubiquitin chain substrate specificity, to deubiquitinating enzyme USP37. (PubMed id 24324262)1 Tanno H....Komada M. (J. Biol. Chem. 2014)
    8. The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability. (PubMed id 23208507)1 Yang W.C. and Shih H.M. (Oncogene 2013)
    9. The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation. (PubMed id 22665064)1 Das C.M....Gopalakrishnan V. (Oncogene 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57695 HGNC: 20063 AceView: USP37 Ensembl:ENSG00000135913 euGenes: HUgn57695
    ECgene: USP37 H-InvDB: USP37

    (According to HUGE)
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    HUGE: KIAA1594

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP37 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP37 gene:
    Search GeneIP for patents involving USP37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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