Free for academic non-profit institutions. Other users need a Commercial license

Aliases for USP37 Gene

Aliases for USP37 Gene

  • Ubiquitin Specific Peptidase 37 2 3
  • Ubiquitin-Specific-Processing Protease 37 3 4
  • Ubiquitin Specific Protease 37 2 3
  • Deubiquitinating Enzyme 37 3 4
  • Ubiquitin Thioesterase 37 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 37 3
  • Ubiquitin Thiolesterase 37 3
  • Tmp_locus_50 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 64
  • KIAA1594 4

External Ids for USP37 Gene

Summaries for USP37 Gene

GeneCards Summary for USP37 Gene

USP37 (Ubiquitin Specific Peptidase 37) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include protein kinase binding and cysteine-type endopeptidase activity. An important paralog of this gene is USP29.

UniProtKB/Swiss-Prot for USP37 Gene

  • Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of Lys-11-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of Lys-48-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2).

Gene Wiki entry for USP37 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP37 Gene

Genomics for USP37 Gene

Genomic Location for USP37 Gene

Start:
218,450,251 bp from pter
End:
218,568,361 bp from pter
Size:
118,111 bases
Orientation:
Minus strand

Genomic View for USP37 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP37 Gene

Regulatory Elements for USP37 Gene

Proteins for USP37 Gene

  • Protein details for USP37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T82-UBP37_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 37
    Protein Accession:
    Q86T82
    Secondary Accessions:
    • A2RUQ8
    • B7ZM38
    • B7ZM41
    • E9PHL3
    • Q2KHT2
    • Q53S10
    • Q7Z3A5
    • Q9HCH8

    Protein attributes for USP37 Gene

    Size:
    979 amino acids
    Molecular mass:
    110170 Da
    Quaternary structure:
    • Interacts with FZR1/CDH1.
    SequenceCaution:
    • Sequence=AAY14887.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for USP37 Gene

    Alternative splice isoforms for USP37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP37 Gene

Proteomics data for USP37 Gene at MOPED

Selected DME Specific Peptides for USP37 Gene

Post-translational modifications for USP37 Gene

  • Phosphorylated at Ser-628 by CDK2 during G1/S phase but not during mitosis; phosphorylation at Ser-628 is required for deubiquitinase activity. Also polyubiquitinated during early G1 phase, without leading to degradation.
  • Polyubiquitinated via Lys-11-linked ubiquitin by the APC(CDH1) complex during late mitosis, leading to its degradation. Able to mediate auto-deubiquitination.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP37 Gene

Domains for USP37 Gene

Gene Families for USP37 Gene

HGNC:
  • USP :Ubiquitin-specific peptidases

UniProtKB/Swiss-Prot:

UBP37_HUMAN
Domain:
  • The KEN box 3 is required for interaction with FZR1/CDH1 and is essential for APC(CDH1)-mediated ubiquitination.:
    • Q86T82
  • Contains 3 UIM (ubiquitin-interacting motif) domains.:
    • Q86T82
  • Contains 1 USP domain.:
    • Q86T82
Family:
  • Belongs to the peptidase C19 family.:
    • Q86T82
genes like me logo Genes that share domains with USP37: view

Function for USP37 Gene

Molecular function for USP37 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function: Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of Lys-11-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of Lys-48-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2).
UniProtKB/Swiss-Prot Induction: Induced by E2F transcription factors in G1.

Enzyme Numbers (IUBMB) for USP37 Gene

Gene Ontology (GO) - Molecular Function for USP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IDA 21596315
GO:0004843 ubiquitin-specific protease activity IDA 14715245
GO:0005515 protein binding IPI 21596315
GO:0019901 protein kinase binding IPI 21596315
GO:0036459 ubiquitinyl hydrolase activity --
genes like me logo Genes that share ontologies with USP37: view
genes like me logo Genes that share phenotypes with USP37: view

miRNA for USP37 Gene

miRTarBase miRNAs that target USP37

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for USP37 Gene

Localization for USP37 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP37 Gene COMPARTMENTS Subcellular localization image for USP37 gene
Compartment Confidence
nucleus 4
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for USP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with USP37: view

Pathways for USP37 Gene

genes like me logo Genes that share pathways with USP37: view

Pathways by source for USP37 Gene

1 Qiagen pathway for USP37 Gene

Gene Ontology (GO) - Biological Process for USP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 21596315
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0007067 mitotic nuclear division IEA --
GO:0016579 protein deubiquitination IDA 14715245
GO:0035871 protein K11-linked deubiquitination IDA 21596315
genes like me logo Genes that share ontologies with USP37: view

Compounds for USP37 Gene

(1) HMDB Compounds for USP37 Gene

Compound Synonyms Cas Number PubMed IDs
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with USP37: view

Transcripts for USP37 Gene

Unigene Clusters for USP37 Gene

Ubiquitin specific peptidase 37:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP37 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a ·
SP1: - - - -
SP2: - - -
SP3: -
SP4:
SP5:

ExUns: 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for USP37 Gene

GeneLoc Exon Structure for
USP37
ECgene alternative splicing isoforms for
USP37

Expression for USP37 Gene

mRNA expression in normal human tissues for USP37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP37 Gene

This gene is overexpressed in Testis (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP37 Gene

SOURCE GeneReport for Unigene cluster for USP37 Gene Hs.166068

mRNA Expression by UniProt/SwissProt for USP37 Gene

Q86T82-UBP37_HUMAN
Tissue specificity: Expressed in brain and prostate.
genes like me logo Genes that share expressions with USP37: view

Orthologs for USP37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for USP37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP37 36
  • 99.76 (n)
  • 99.8 (a)
USP37 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia USP37 36
  • 93.5 (n)
  • 94.89 (a)
USP37 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP37 36
  • 93.8 (n)
  • 95.91 (a)
USP37 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp37 36
  • 88.74 (n)
  • 90.79 (a)
Usp37 16
Usp37 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia USP37 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP37 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp37 36
  • 89.49 (n)
  • 91.81 (a)
chicken
(Gallus gallus)
Aves USP37 36
  • 75.04 (n)
  • 78.46 (a)
USP37 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP37 37
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32185 36
tropical clawed frog
(Silurana tropicalis)
Amphibia usp37 36
  • 66.39 (n)
  • 67.05 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9946 36
zebrafish
(Danio rerio)
Actinopterygii usp37 36
  • 61.66 (n)
  • 61.01 (a)
usp37 37
  • 58 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2829 37
  • 29 (a)
OneToMany
Species with no ortholog for USP37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP37 Gene

ENSEMBL:
Gene Tree for USP37 (if available)
TreeFam:
Gene Tree for USP37 (if available)

Paralogs for USP37 Gene

Paralogs for USP37 Gene

Selected SIMAP similar genes for USP37 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for USP37 Gene

genes like me logo Genes that share paralogs with USP37: view

Variants for USP37 Gene

Sequence variations from dbSNP and Humsavar for USP37 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs14998 -- 218,450,371(+) CACAG(A/T)TAAAA utr-variant-3-prime
rs483172 -- 218,563,576(+) AGGCT(C/T)CACTA intron-variant
rs484085 -- 218,531,961(-) accag(A/G)attag intron-variant
rs485975 -- 218,509,527(+) GAGGA(C/T)TGCTT intron-variant
rs490483 -- 218,564,329(+) tttta(A/T)aataa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP37 Gene

Variant ID Type Subtype PubMed ID
nsv508199 CNV Loss 20534489
nsv3167 CNV Insertion 18451855
nsv3168 CNV Loss 18451855
esv2518247 CNV Insertion 19546169
esv1137385 CNV Insertion 17803354
nsv875861 CNV Gain 21882294

Relevant External Links for USP37 Gene

HapMap Linkage Disequilibrium report
USP37

Disorders for USP37 Gene

Relevant External Links for USP37

Genetic Association Database (GAD)
USP37
Human Genome Epidemiology (HuGE) Navigator
USP37
genes like me logo Genes that share disorders with USP37: view

No data available for UniProtKB/Swiss-Prot for USP37 Gene

Publications for USP37 Gene

  1. Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. (PMID: 21596315) Huang X. … Dixit V.M. (Mol. Cell 2011) 3 4
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 3 4
  4. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 49

Products for USP37 Gene

  • Addgene plasmids for USP37

Sources for USP37 Gene

Back to Top

Content