Free for academic non-profit institutions. Other users need a Commercial license

Aliases for USP36 Gene

Aliases for USP36 Gene

  • Ubiquitin Specific Peptidase 36 2 3 5
  • Ubiquitin-Specific-Processing Protease 36 3 4
  • Ubiquitin Specific Protease 36 2 3
  • Deubiquitinating Enzyme 36 3 4
  • Ubiquitin Thioesterase 36 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase 36 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 58
  • KIAA1453 4
  • DUB1 3

External Ids for USP36 Gene

Previous GeneCards Identifiers for USP36 Gene

  • GC17M077244
  • GC17M077380
  • GC17M074295
  • GC17M076792
  • GC17M072215
  • GC17M076783

Summaries for USP36 Gene

Entrez Gene Summary for USP36 Gene

  • This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]

GeneCards Summary for USP36 Gene

USP36 (Ubiquitin Specific Peptidase 36) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include poly(A) RNA binding and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP42.

UniProtKB/Swiss-Prot for USP36 Gene

  • May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 Lys-4 trimethylation (H3K4) (By similarity).

Gene Wiki entry for USP36 Gene

Additional gene information for USP36 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP36 Gene

Genomics for USP36 Gene

Regulatory Elements for USP36 Gene

Enhancers for USP36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H078733 2.1 FANTOM5 Ensembl ENCODE dbSUPER 72.6 +94.6 94566 27 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZNF585B GLIS1 RCOR2 USP36 CYTH1 SOCS3 RNU6-638P TNRC6C DNAH17 ENGASE TNRC6C-AS1 PGS1
GH17H078120 2 FANTOM5 Ensembl ENCODE dbSUPER 43.3 +713.5 713492 14 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 USP36 TMC8 TMC6 SYNGR2 AFMID TK1 TNRC6C-AS1 ENGASE PGS1 TNRC6C
GH17H078557 1.4 Ensembl ENCODE 61.3 +283.6 283612 1 FOXA2 ARNT ARID4B FEZF1 ZNF302 ZNF416 FOS ZNF548 SP3 MXD4 USP36 TNRC6C DNAH17 ENGASE RNU6-638P CANT1 GC17M078554
GH17H078268 2 FANTOM5 Ensembl ENCODE dbSUPER 41 +569.9 569870 5 HDGF PKNOX1 ARNT SIN3A ZNF766 REST SMARCB1 ZNF592 MEF2D SMARCA4 USP36 PGS1 TMEM235 ENSG00000200063 ENGASE TMC8 TMC6 SOCS3 TNRC6C LINC01993
GH17H078777 2 FANTOM5 Ensembl ENCODE dbSUPER 36.9 +59.8 59756 8 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 USP36 CYTH1 ENGASE RNU6-638P TNRC6C-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around USP36 on UCSC Golden Path with GeneCards custom track

Promoters for USP36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098981 941 2201 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for USP36 Gene

Chromosome:
17
Start:
78,787,381 bp from pter
End:
78,841,441 bp from pter
Size:
54,061 bases
Orientation:
Minus strand

Genomic View for USP36 Gene

Genes around USP36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP36 Gene

Proteins for USP36 Gene

  • Protein details for USP36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P275-UBP36_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 36
    Protein Accession:
    Q9P275
    Secondary Accessions:
    • Q05C98
    • Q05DD0
    • Q6IQ38
    • Q8NDM8
    • Q9NVC8

    Protein attributes for USP36 Gene

    Size:
    1121 amino acids
    Molecular mass:
    122652 Da
    Quaternary structure:
    • Interacts with PAF1.
    SequenceCaution:
    • Sequence=AAH16487.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA95977.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for USP36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP36 Gene

Selected DME Specific Peptides for USP36 Gene

Q9P275:
  • QCLTYTPPLANY
  • NLGNTCF

Post-translational modifications for USP36 Gene

  • Ubiquitination at posLast=338338
  • Modification sites at PhosphoSitePlus

Domains & Families for USP36 Gene

Gene Families for USP36 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for USP36 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P275

UniProtKB/Swiss-Prot:

UBP36_HUMAN :
  • Belongs to the peptidase C19 family.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP36: view

Function for USP36 Gene

Molecular function for USP36 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 Lys-4 trimethylation (H3K4) (By similarity).

Enzyme Numbers (IUBMB) for USP36 Gene

Phenotypes From GWAS Catalog for USP36 Gene

Gene Ontology (GO) - Molecular Function for USP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 14715245
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP36: view
genes like me logo Genes that share phenotypes with USP36: view

Animal Models for USP36 Gene

MGI Knock Outs for USP36:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for USP36
  • Applied Biological Materials Clones for USP36
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP36 Gene

Localization for USP36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP36 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP36 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
  • Nucleoli (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for USP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with USP36: view

Pathways & Interactions for USP36 Gene

genes like me logo Genes that share pathways with USP36: view

Pathways by source for USP36 Gene

1 Qiagen pathway for USP36 Gene

Gene Ontology (GO) - Biological Process for USP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IDA,IEA 14715245
GO:1903146 regulation of mitophagy IMP 24912190
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24912190
genes like me logo Genes that share ontologies with USP36: view

No data available for SIGNOR curated interactions for USP36 Gene

Drugs & Compounds for USP36 Gene

(1) Drugs for USP36 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with USP36: view

Transcripts for USP36 Gene

Unigene Clusters for USP36 Gene

Ubiquitin specific peptidase 36:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for USP36
  • Applied Biological Materials Clones for USP36
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for USP36 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^
SP1: -
SP2: - - - - - - - -
SP3: -
SP4: - - - -
SP5: -
SP6:
SP7: - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9:
SP10:
SP11:
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - -
SP15: -
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

ExUns: 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b · 28c ·
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - -
SP19:
SP20:
SP21:
SP22: -

ExUns: 28d ^ 29 ^ 30 ^ 31
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - -
SP19:
SP20:
SP21:
SP22:

Relevant External Links for USP36 Gene

GeneLoc Exon Structure for
USP36
ECgene alternative splicing isoforms for
USP36

Expression for USP36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for USP36 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.2), Rectum (17.6), Pancreatic juice (8.4), and Uterus (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for USP36 Gene



NURSA nuclear receptor signaling pathways regulating expression of USP36 Gene:

USP36

SOURCE GeneReport for Unigene cluster for USP36 Gene:

Hs.464243

mRNA Expression by UniProt/SwissProt for USP36 Gene:

Q9P275-UBP36_HUMAN
Tissue specificity: Broadly expressed.

Evidence on tissue expression from TISSUES for USP36 Gene

  • Nervous system(4.6)
  • Skin(4.3)
  • Intestine(2.4)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with USP36: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP36 Gene

Orthologs for USP36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP36 33 34
  • 98.86 (n)
dog
(Canis familiaris)
Mammalia USP36 33 34
  • 80.64 (n)
rat
(Rattus norvegicus)
Mammalia Usp36 33
  • 79.85 (n)
cow
(Bos Taurus)
Mammalia USP36 33 34
  • 78.66 (n)
mouse
(Mus musculus)
Mammalia Usp36 33 16 34
  • 78.36 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
OneToMany
-- 34
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia USP36 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP36 33 34
  • 72.28 (n)
lizard
(Anolis carolinensis)
Reptilia USP36 34
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398902 33
zebrafish
(Danio rerio)
Actinopterygii usp36 34
  • 52 (a)
OneToOne
wufd19b04 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12981 33
fruit fly
(Drosophila melanogaster)
Insecta scny 34
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 34
  • 22 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubp16 33
  • 50.84 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2285 33
Species where no ortholog for USP36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP36 Gene

ENSEMBL:
Gene Tree for USP36 (if available)
TreeFam:
Gene Tree for USP36 (if available)

Paralogs for USP36 Gene

genes like me logo Genes that share paralogs with USP36: view

Variants for USP36 Gene

Sequence variations from dbSNP and Humsavar for USP36 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000051845 -- 78,822,350(+) AAGTA(A/C)GTACC intron-variant
rs1000068866 -- 78,803,000(+) GTGAC(A/G)CGATC intron-variant
rs1000069740 -- 78,835,647(+) TTACA(A/G)GACAT intron-variant
rs1000094026 -- 78,789,058(+) CGGGC(A/G)TGATG intron-variant
rs1000144261 -- 78,794,198(+) CTGGC(A/G)GCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP36 Gene

Variant ID Type Subtype PubMed ID
esv3641341 CNV loss 21293372

Variation tolerance for USP36 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.63; 89.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP36 Gene

Human Gene Mutation Database (HGMD)
USP36
SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP36 Gene

Disorders for USP36 Gene

Relevant External Links for USP36

Genetic Association Database (GAD)
USP36
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP36

No disorders were found for USP36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP36 Gene

Publications for USP36 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V … López-Otín C (Biochemical and biophysical research communications 2004) 3 4 60
  4. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3 60
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 60

Products for USP36 Gene

  • Addgene plasmids for USP36

Sources for USP36 Gene

Content
Loading form....