Aliases for USP36 Gene
External Ids for USP36 Gene
Previous GeneCards Identifiers for USP36 Gene
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP36 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jan 2009]
GeneCards Summary for USP36 Gene
USP36 (Ubiquitin Specific Peptidase 36) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include ubiquitin thiolesterase activity and cysteine-type peptidase activity. An important paralog of this gene is USP17L25.
UniProtKB/Swiss-Prot for USP36 Gene
May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 Lys-4 trimethylation (H3K4) (By similarity).