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Aliases for USP36 Gene

Aliases for USP36 Gene

  • Ubiquitin Specific Peptidase 36 2 3
  • Ubiquitin-Specific-Processing Protease 36 3 4
  • Ubiquitin Specific Protease 36 2 3
  • Deubiquitinating Enzyme 36 3 4
  • Ubiquitin Thioesterase 36 3 4
  • KIAA1453 4 6
  • Ubiquitin Carboxyl-Terminal Hydrolase 36 3
  • Ubiquitin Thiolesterase 36 3
  • Deubiquitinating Enzyme 1 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 63
  • DUB1 3

External Ids for USP36 Gene

Previous GeneCards Identifiers for USP36 Gene

  • GC17M077244
  • GC17M077380
  • GC17M074295
  • GC17M076792
  • GC17M072215
  • GC17M076783

Summaries for USP36 Gene

Entrez Gene Summary for USP36 Gene

  • Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP36 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jan 2009]

GeneCards Summary for USP36 Gene

USP36 (Ubiquitin Specific Peptidase 36) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include ubiquitin thiolesterase activity and cysteine-type peptidase activity. An important paralog of this gene is USP17L25.

UniProtKB/Swiss-Prot for USP36 Gene

  • May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 Lys-4 trimethylation (H3K4) (By similarity).

Gene Wiki entry for USP36 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP36 Gene

Genomics for USP36 Gene

Regulatory Elements for USP36 Gene

Genomic Location for USP36 Gene

Start:
78,787,381 bp from pter
End:
78,841,441 bp from pter
Size:
54,061 bases
Orientation:
Minus strand

Genomic View for USP36 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP36 Gene

Proteins for USP36 Gene

  • Protein details for USP36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P275-UBP36_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 36
    Protein Accession:
    Q9P275
    Secondary Accessions:
    • Q05C98
    • Q05DD0
    • Q6IQ38
    • Q8NDM8
    • Q9NVC8

    Protein attributes for USP36 Gene

    Size:
    1121 amino acids
    Molecular mass:
    122652 Da
    Quaternary structure:
    • Interacts with PAF1.
    SequenceCaution:
    • Sequence=AAH16487.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA95977.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for USP36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP36 Gene

Proteomics data for USP36 Gene at MOPED

Selected DME Specific Peptides for USP36 Gene

Post-translational modifications for USP36 Gene

  • Ubiquitination at Lys338
  • Modification sites at PhosphoSitePlus

Domains for USP36 Gene

Gene Families for USP36 Gene

HGNC:
  • USP :Ubiquitin-specific peptidases

Protein Domains for USP36 Gene

Suggested Antigen Peptide Sequences for USP36 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P275

UniProtKB/Swiss-Prot:

UBP36_HUMAN :
  • Q9P275
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP36: view

Function for USP36 Gene

Molecular function for USP36 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function: May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 Lys-4 trimethylation (H3K4) (By similarity).

Enzyme Numbers (IUBMB) for USP36 Gene

Gene Ontology (GO) - Molecular Function for USP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0004843 ubiquitin-specific protease activity IDA 14715245
GO:0036459 ubiquitinyl hydrolase activity --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with USP36: view

Phenotypes for USP36 Gene

genes like me logo Genes that share phenotypes with USP36: view

Animal Model Products

CRISPR Products

miRNA for USP36 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for USP36 Gene

Localization for USP36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP36 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP36 Gene COMPARTMENTS Subcellular localization image for USP36 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for USP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with USP36: view

Pathways for USP36 Gene

genes like me logo Genes that share pathways with USP36: view

Pathways by source for USP36 Gene

1 Qiagen pathway for USP36 Gene

Gene Ontology (GO) - Biological Process for USP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0016579 protein deubiquitination IDA 14715245
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0061136 regulation of proteasomal protein catabolic process IBA --
genes like me logo Genes that share ontologies with USP36: view

Compounds for USP36 Gene

(1) HMDB Compounds for USP36 Gene

Compound Synonyms Cas Number PubMed IDs
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with USP36: view

Transcripts for USP36 Gene

Unigene Clusters for USP36 Gene

Ubiquitin specific peptidase 36:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP36

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP36 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^
SP1: -
SP2: - - - - - - - -
SP3: -
SP4: - - - -
SP5: -
SP6:
SP7: - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9:
SP10:
SP11:
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - -
SP15: -
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

ExUns: 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b · 28c ·
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - -
SP19:
SP20:
SP21:
SP22: -

ExUns: 28d ^ 29 ^ 30 ^ 31
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - -
SP19:
SP20:
SP21:
SP22:

Relevant External Links for USP36 Gene

GeneLoc Exon Structure for
USP36
ECgene alternative splicing isoforms for
USP36

Expression for USP36 Gene

mRNA expression in normal human tissues for USP36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP36 Gene

SOURCE GeneReport for Unigene cluster for USP36 Gene Hs.464243

mRNA Expression by UniProt/SwissProt for USP36 Gene

Q9P275-UBP36_HUMAN
Tissue specificity: Broadly expressed.
genes like me logo Genes that share expressions with USP36: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for USP36 Gene

Orthologs for USP36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP36 35
  • 98.86 (n)
  • 98.45 (a)
USP36 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia USP36 35
  • 78.66 (n)
  • 74.18 (a)
USP36 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP36 35
  • 80.64 (n)
  • 75.4 (a)
USP36 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp36 35
  • 78.36 (n)
  • 75.37 (a)
Usp36 16
Usp36 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia USP36 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp36 35
  • 79.85 (n)
  • 76.67 (a)
chicken
(Gallus gallus)
Aves USP36 35
  • 72.28 (n)
  • 70.3 (a)
USP36 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP36 36
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398902 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12981 35
zebrafish
(Danio rerio)
Actinopterygii usp36 36
  • 52 (a)
OneToOne
wufd19b04 35
fruit fly
(Drosophila melanogaster)
Insecta scny 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 36
  • 22 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubp16 35
  • 50.84 (n)
  • 47.49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2285 35
Species with no ortholog for USP36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP36 Gene

ENSEMBL:
Gene Tree for USP36 (if available)
TreeFam:
Gene Tree for USP36 (if available)

Paralogs for USP36 Gene

genes like me logo Genes that share paralogs with USP36: view

Variants for USP36 Gene

Sequence variations from dbSNP and Humsavar for USP36 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs747423 -- 78,788,699(+) GGACT(C/T)GGGTC intron-variant
rs867596 -- 78,795,135(-) ATTTG(C/T)GTTGT intron-variant
rs900348 -- 78,837,347(-) TGCTT(G/T)GCTTT intron-variant
rs900349 -- 78,836,051(-) GATGG(A/G)CTTAA intron-variant
rs931226 -- 78,824,498(-) ggtgc(A/G)atctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP36 Gene

Variant ID Type Subtype PubMed ID
nsv908893 CNV Loss 21882294
nsv908894 CNV Loss 21882294

Relevant External Links for USP36 Gene

HapMap Linkage Disequilibrium report
USP36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP36 Gene

Disorders for USP36 Gene

Relevant External Links for USP36

Genetic Association Database (GAD)
USP36
genes like me logo Genes that share disorders with USP36: view

No data available for UniProtKB/Swiss-Prot for USP36 Gene

Publications for USP36 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  4. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for USP36 Gene

Sources for USP36 Gene

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