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USP36 Gene

protein-coding   GIFtS: 57
GCID: GC17M076783

Ubiquitin Specific Peptidase 36

(Previous name: ubiquitin specific protease 36)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 361 2     DUB12
Ubiquitin Specific Protease 361 2     Deubiquitinating Enzyme 12
Deubiquitinating Enzyme 362 3     Ubiquitin Carboxyl-Terminal Hydrolase 362
Ubiquitin Thioesterase 362 3     Ubiquitin Thiolesterase 362
Ubiquitin-Specific-Processing Protease 362 3     EC 3.4.19.123
KIAA14533 5     EC 3.1.2.158

External Ids:    HGNC: 200621   Entrez Gene: 576022   Ensembl: ENSG000000554837   OMIM: 6125435   UniProtKB: Q9P2753   

Export aliases for USP36 gene to outside databases

Previous GC identifers: GC17M077244 GC17M077380 GC17M074295 GC17M076792 GC17M072215


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USP36 Gene:
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated
action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP36 belongs to a large family of
cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 (PubMed 14715245)).(supplied
by OMIM, Jan 2009)

GeneCards Summary for USP36 Gene:
USP36 (ubiquitin specific peptidase 36) is a protein-coding gene. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP17L13.

UniProtKB/Swiss-Prot: UBP36_HUMAN, Q9P275
Function: May be required for maintaining multiple types of adult stem cells. May function as a transcriptional
repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular
differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity)

Gene Wiki entry for USP36 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP36 gene promoter:
         Egr-3   HOXA9   HOXA9B   AML1a   AREB6   PPAR-gamma1   Meis-1a   PPAR-gamma2   GCNF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP36 promoter sequence
   Search Chromatin IP Primers for USP36

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

USP36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP36 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M076783:  view genomic region     (about GC identifiers)

Start:
76,783,463 bp from pter      End:
76,837,523 bp from pter
Size:
54,061 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBP36_HUMAN, Q9P275 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 36  
Size: 1121 amino acids; 122652 Da
Subunit: Interacts with PAF1 (By similarity)
Sequence caution: Sequence=AAH16487.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAA95977.1; Type=Erroneous initiation;
Secondary accessions: Q05C98 Q05DD0 Q6IQ38 Q8NDM8 Q9NVC8
Alternative splicing: 2 isoforms:  Q9P275-1   Q9P275-2   

Explore the universe of human proteins at neXtProt for USP36: NX_Q9P275

Explore proteomics data for USP36 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys338
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for USP36 (Q9P275)
     NLGNTCF  QCLTYTPPLANY 


    See USP36 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079366.3  
    ENSEMBL proteins: 
     ENSP00000465679   ENSP00000464746   ENSP00000468356   ENSP00000467280   ENSP00000464886  
     ENSP00000465698   ENSP00000441214   ENSP00000468549   ENSP00000466567   ENSP00000466187  
     ENSP00000467682   ENSP00000467520   ENSP00000475654   ENSP00000467951   ENSP00000466212  
     ENSP00000468194   ENSP00000465183   ENSP00000310590   ENSP00000401119  

    USP36 Human Recombinant Protein Products:

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    Novus Biologicals USP36 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP36

     
    Search eBioscience for Proteins for USP36 

     
    Search antibodies-online for proteins for USP36 

     
    antibodies-online peptides for USP36

    USP36 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    antibodies-online antibodies for USP36 (26 products) 

    USP36 Assay Products:

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    Cloud-Clone Corp. ELISAs for USP36
    Cloud-Clone Corp. CLIAs for USP36
    Search eBioscience for ELISAs for USP36 
    antibodies-online kits for USP36 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    3 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028889 UCH/PAN2

    Graphical View of Domain Structure for InterPro Entry Q9P275

    ProtoNet protein and cluster: Q9P275

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP36_HUMAN, Q9P275
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP36           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP36_HUMAN, Q9P275
    Function: May be required for maintaining multiple types of adult stem cells. May function as a transcriptional
    repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular
    differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity)
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity ----
    GO:0004843ubiquitin-specific protease activity IDA14715245
    GO:0008234cysteine-type peptidase activity ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with USP36           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for USP36:
     Decreased cilium length  Decreased cilium length after   Increased G2M DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for USP36

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP36:
    hsa-mir-151a-3p (MIRT043617), hsa-mir-615-3p (MIRT040098), hsa-mir-98-5p (MIRT027793), hsa-mir-342-5p (MIRT038207)

    Block miRNA regulation of human, mouse, rat USP36 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate USP36:
    hsa-miR-153 hsa-miR-448 hsa-miR-4261 hsa-miR-137 hsa-miR-526b hsa-miR-494 hsa-miR-1279
    SwitchGear 3'UTR luciferase reporter plasmidUSP36 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat USP36

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP36
    Addgene plasmids for USP36 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP36


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBP36_HUMAN, Q9P275: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    Find genes that share ontologies with USP36           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP36 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP36
        Ubiquitin-Proteasome Dependent Proteolysis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP36
    Interactions:

        Search GeneGlobe Interaction Network for USP36

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP36 (Q9P2753 ENSP000003105904) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX41Q9UJV93, ENSP000003303494I2D: score=2 STRING: ENSP00000330349
    MPNDQ8N5943, ENSP000002629664I2D: score=2 STRING: ENSP00000262966
    NUDCD1Q96RS63, ENSP000002396904I2D: score=2 STRING: ENSP00000239690
    NUP85Q9BW273, ENSP000002455444I2D: score=2 STRING: ENSP00000245544
    PPM1GO153553, ENSP000002647144I2D: score=2 STRING: ENSP00000264714
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016579protein deubiquitination IDA14715245

    Find genes that share ontologies with USP36           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP36 (UBP36)

    1 HMDB Compound for USP36    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP36 gene: 
    NM_025090.3  

    Unigene Cluster for USP36:

    Ubiquitin specific peptidase 36
    Hs.464243  [show with all ESTs]
    Unigene Representative Sequence: AB040886
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000587010 ENST00000588130 ENST00000591052 ENST00000589225 ENST00000587379
    ENST00000592326 ENST00000592231 ENST00000542802(uc002jwb.1) ENST00000588086
    ENST00000588467 ENST00000586066 ENST00000590312 ENST00000589254 ENST00000589424
    ENST00000590546 ENST00000586531 ENST00000591942 ENST00000586896
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP36 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate USP36:
    hsa-miR-153 hsa-miR-448 hsa-miR-4261 hsa-miR-137 hsa-miR-526b hsa-miR-494 hsa-miR-1279
    SwitchGear 3'UTR luciferase reporter plasmidUSP36 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat USP36
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP36
    Addgene plasmids for USP36 
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      QuantiTect SYBR Green Assays in human, mouse, rat USP36
      QuantiFast Probe-based Assays in human, mouse, rat USP36

    Additional mRNA sequence: 

    AB040886.1 AK001671.1 AK022840.1 AK022913.1 AK023077.1 AK225155.1 AK225426.1 AL359624.1 
    AL833835.1 AY169386.1 BC013890.2 BC016487.1 BC027992.1 BC038983.1 BC071582.1 BC127878.1 

    15 DOTS entries:

    DT.40298812  DT.91716985  DT.99995686  DT.100793566  DT.91757797  DT.100793565  DT.99948111  DT.75189278 
    DT.100734276  DT.120900314  DT.95175307  DT.100665278  DT.409464  DT.95195929  DT.97809646 

    Selected AceView cDNA sequences (see all 235):

    BM563338 AL833835 BU178539 BM707677 CA436711 AI051608 AA227347 AW189044 
    BF430981 BX484637 BM127734 AA548847 BG742510 AI206206 AW513928 AL359624 
    BG982644 CA446732 AU132938 BQ651615 BF589402 BC016487 AA422146 BM832462 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for USP36 (see all 22)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^
    SP1:                                                                                                                                                        -   
    SP2:                                -     -     -     -     -     -     -     -                                                                                 
    SP3:                                                                                                                                                        -   
    SP4:                                                        -     -     -     -                                                                                 
    SP5:                                                                                                                                                        -   

    ExUns: 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b · 28c ·
    SP1:        -                 -                                                                                                                                 
    SP2:                                                                                                                                                            
    SP3:        -                                                                                                                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 28d ^ 29 ^ 30 ^ 31
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for USP36

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP36 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGCACCTG
    USP36 Expression
    About this image


    USP36 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Cartilage (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Breast (Uncategorized)
    USP36 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP36 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.464243

    UniProtKB/Swiss-Prot: UBP36_HUMAN, Q9P275
    Tissue specificity: Broadly expressed

        Custom PCR Arrays for USP36
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP36

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP36 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp361 , 5 ubiquitin specific peptidase 361, 5 78.36(n)1
    75.37(a)1
      11 (83.06 cM)5
    723441  NM_001033528.11  NP_001028700.11 
     1182596515 
    chicken
    (Gallus gallus)
    Aves USP361 ubiquitin specific peptidase 36 72.28(n)
    70.3(a)
      426457  XM_424101.4  XP_424101.3 
    lizard
    (Anolis carolinensis)
    Reptilia USP366
    ubiquitin specific peptidase 36
    57(a)
    1 ↔ 1
    2(101780982-101803194)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3989022 hypothetical protein LOC398902 75.89(n)    BC060390.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd19b042 Danio rerio cDNA clone IMAGE5413509, partial cds 77.84(n)    BC057470.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta scny6
    scrawny
    23(a)
    1 → many
    3L(5762223-5769371)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP86
    Ubiquitin-specific protease that is a component of...
    22(a)
    1 → many
    XIII(716715-718130) YMR223W


    ENSEMBL Gene Tree for USP36 (if available)
    TreeFam Gene Tree for USP36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP36 gene
    USP17L132  USP17L282  USP17L242  USP222  USP17L302  USP17L122  USP17L172  USP17L232  
    USP17L262  USP17L182  USP512  USP422  USP17L252  USP17L152  USP17L202  USP17L192  
    USP17L212  USP17L102  USP17L272  USP27X2  USP17L222  USP17L22  USP17L292  USP17L52  
    USP17L112  
    Selected SIMAP similar genes for USP36 using alignment to 16 protein entries:     UBP36_HUMAN (see all proteins) (see all similar genes):
    DUB1    USP17L7    USP17L1P    USP17L4    USP17L8    USP17L11
    USP17L23    USP17L6P    USP17L17    USP17L18    USP17L19    USP17L22
    USP17L12    USP17L15    USP17L20    USP17L21    USP17L24    USP17L25

    Find genes that share paralogs with USP36           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP36 (see all 1380)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs743365511,2
    C,F--76792490(+) AGACTG/AGTCCG 1 -- ds50011Minor allele frequency- A:0.06WA 118
    rs118703661,2
    H--76792533(+) TGCTGC/TTGGGA 1 -- ds50010--------
    rs1396868881,2
    C--76792591(+) GAAACA/GTAAAA 1 -- ds50010--------
    rs611593161,2
    C,F--76792610(+) AAATCC/AAAAAA 1 -- ds50011Minor allele frequency- A:0.17EA 120
    rs1808409341,2
    --76792743(+) GAGAGC/GGGGTG 1 -- ds50010--------
    rs582062591,2
    C,F--76792798(+) CAGCAG/AAGCCA 1 -- ds50011Minor allele frequency- A:0.17EA 120
    rs1440581201,2
    --76792823(+) TAAGTC/TCAACA 1 -- ds50010--------
    rs22793091,2
    C,F,H--76792833(+) ACCACG/ATTGTC 1 -- ds500129Minor allele frequency- A:0.08EA NA NS WA CSA 5724
    rs22793101,2
    C,F,H--76792870(+) GGAAAT/CGACGG 1 -- ds500129Minor allele frequency- C:0.11EA NA NS WA CSA 4348
    rs1169801891,2
    C,F--76793005(+) GTTGGC/TAGGCA 1 -- ut311Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for USP36 (76783463 - 76837523 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for USP36:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908893CNV Loss21882294
    nsv908894CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP36
    DNA2.0 Custom Variant and Variant Library Synthesis for USP36

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612543    OMIM disorders: --


    Find genes that share disorders with USP36           About GenesLikeMe

    Genetic Association Database (GAD): USP36

    Export disorders for USP36 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP36 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with USP36)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004)
    4. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    5. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    6. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins. (PubMed id 22622177)1 Taillebourg E....Fauvarque M.O. (Autophagy 2012)
    9. Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. (PubMed id 23105109)1 Hayes S.D....UrbAc S. (J. Biol. Chem. 2012)
    10. Integrating genetic association, genetics of gene expression, and single nucleotide polymorphism set analysis to identify susceptibility Loci for type 2 diabetes mellitus. (PubMed id 22865700)1 Greenawalt D.M....Hu F.B. (Am. J. Epidemiol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57602 HGNC: 20062 AceView: USP36 Ensembl:ENSG00000055483 euGenes: HUgn57602
    ECgene: USP36 H-InvDB: USP36

    (According to HUGE)
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    HUGE: KIAA1453

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for USP36 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for USP36 gene:
    Search GeneIP for patents involving USP36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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