Aliases for USP36 Gene
External Ids for USP36 Gene
Previous GeneCards Identifiers for USP36 Gene
This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]
GeneCards Summary for USP36 Gene
USP36 (Ubiquitin Specific Peptidase 36) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include poly(A) RNA binding and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP42.
UniProtKB/Swiss-Prot for USP36 Gene
May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 Lys-4 trimethylation (H3K4) (By similarity).