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Aliases for USP36 Gene

Aliases for USP36 Gene

  • Ubiquitin Specific Peptidase 36 2 3 5
  • Ubiquitin-Specific-Processing Protease 36 3 4
  • Ubiquitin Specific Protease 36 2 3
  • Deubiquitinating Enzyme 36 3 4
  • Ubiquitin Thioesterase 36 3 4
  • EC 3.4.19.12 4
  • EC 3.1.2.15 63
  • KIAA1453 4
  • DUB1 3

External Ids for USP36 Gene

Previous GeneCards Identifiers for USP36 Gene

  • GC17M077244
  • GC17M077380
  • GC17M074295
  • GC17M076792
  • GC17M072215
  • GC17M076783

Summaries for USP36 Gene

Entrez Gene Summary for USP36 Gene

  • This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]

GeneCards Summary for USP36 Gene

USP36 (Ubiquitin Specific Peptidase 36) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include poly(A) RNA binding and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP17L25.

UniProtKB/Swiss-Prot for USP36 Gene

  • May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 Lys-4 trimethylation (H3K4) (By similarity).

Gene Wiki entry for USP36 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP36 Gene

Genomics for USP36 Gene

Regulatory Elements for USP36 Gene

Promoters for USP36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around USP36 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP36 Gene

Chromosome:
17
Start:
78,787,381 bp from pter
End:
78,841,441 bp from pter
Size:
54,061 bases
Orientation:
Minus strand

Genomic View for USP36 Gene

Genes around USP36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP36 Gene

Proteins for USP36 Gene

  • Protein details for USP36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P275-UBP36_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 36
    Protein Accession:
    Q9P275
    Secondary Accessions:
    • Q05C98
    • Q05DD0
    • Q6IQ38
    • Q8NDM8
    • Q9NVC8

    Protein attributes for USP36 Gene

    Size:
    1121 amino acids
    Molecular mass:
    122652 Da
    Quaternary structure:
    • Interacts with PAF1.
    SequenceCaution:
    • Sequence=AAH16487.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA95977.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for USP36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP36 Gene

Proteomics data for USP36 Gene at MOPED

Selected DME Specific Peptides for USP36 Gene

Post-translational modifications for USP36 Gene

  • Ubiquitination at Lys 338
  • Modification sites at PhosphoSitePlus

Domains & Families for USP36 Gene

Gene Families for USP36 Gene

Protein Domains for USP36 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P275

UniProtKB/Swiss-Prot:

UBP36_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP36: view

Function for USP36 Gene

Molecular function for USP36 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 Lys-4 trimethylation (H3K4) (By similarity).

Enzyme Numbers (IUBMB) for USP36 Gene

Gene Ontology (GO) - Molecular Function for USP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with USP36: view
genes like me logo Genes that share phenotypes with USP36: view

Animal Models for USP36 Gene

MGI Knock Outs for USP36:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP36 Gene

Localization for USP36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP36 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP36 Gene COMPARTMENTS Subcellular localization image for USP36 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for USP36 Gene

Pathways & Interactions for USP36 Gene

genes like me logo Genes that share pathways with USP36: view

Pathways by source for USP36 Gene

1 Qiagen pathway for USP36 Gene

Gene Ontology (GO) - Biological Process for USP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with USP36: view

No data available for SIGNOR curated interactions for USP36 Gene

Drugs & Compounds for USP36 Gene

(1) Additional Compounds for USP36 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with USP36: view

Transcripts for USP36 Gene

Unigene Clusters for USP36 Gene

Ubiquitin specific peptidase 36:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP36 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^
SP1: -
SP2: - - - - - - - -
SP3: -
SP4: - - - -
SP5: -
SP6:
SP7: - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9:
SP10:
SP11:
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - -
SP15: -
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

ExUns: 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b · 28c ·
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - -
SP19:
SP20:
SP21:
SP22: -

ExUns: 28d ^ 29 ^ 30 ^ 31
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - -
SP19:
SP20:
SP21:
SP22:

Relevant External Links for USP36 Gene

GeneLoc Exon Structure for
USP36
ECgene alternative splicing isoforms for
USP36

Expression for USP36 Gene

mRNA expression in normal human tissues for USP36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for USP36 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.2), Rectum (17.6), Pancreatic juice (8.4), and Uterus (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP36 Gene



SOURCE GeneReport for Unigene cluster for USP36 Gene Hs.464243

mRNA Expression by UniProt/SwissProt for USP36 Gene

Q9P275-UBP36_HUMAN
Tissue specificity: Broadly expressed.
genes like me logo Genes that share expression patterns with USP36: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for USP36 Gene

Orthologs for USP36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP36 35
  • 98.86 (n)
  • 98.45 (a)
USP36 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia USP36 36
  • 73 (a)
OneToOne
USP36 35
  • 78.66 (n)
  • 74.18 (a)
dog
(Canis familiaris)
Mammalia USP36 35
  • 80.64 (n)
  • 75.4 (a)
USP36 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp36 16
Usp36 35
  • 78.36 (n)
  • 75.37 (a)
Usp36 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia USP36 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp36 35
  • 79.85 (n)
  • 76.67 (a)
chicken
(Gallus gallus)
Aves USP36 36
  • 54 (a)
OneToOne
USP36 35
  • 72.28 (n)
  • 70.3 (a)
lizard
(Anolis carolinensis)
Reptilia USP36 36
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398902 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12981 35
zebrafish
(Danio rerio)
Actinopterygii wufd19b04 35
usp36 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta scny 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP8 36
  • 22 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubp16 35
  • 50.84 (n)
  • 47.49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2285 35
Species with no ortholog for USP36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP36 Gene

ENSEMBL:
Gene Tree for USP36 (if available)
TreeFam:
Gene Tree for USP36 (if available)

Paralogs for USP36 Gene

genes like me logo Genes that share paralogs with USP36: view

Variants for USP36 Gene

Sequence variations from dbSNP and Humsavar for USP36 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3744793 - 78,821,008(-) TGGAC(A/G)TCGCG nc-transcript-variant, reference, missense
rs3744795 - 78,807,577(-) CCCAT(A/G)TCCAG nc-transcript-variant, reference, missense
rs9889908 - 78,803,871(+) AGCTC(A/C/T)GTGGT intron-variant, nc-transcript-variant, reference, missense
rs3088040 - 78,803,778(-) CCCCC(A/C/G)GAGCC intron-variant, nc-transcript-variant, reference, missense
rs3744797 - 78,803,753(-) AAAAA(G/T)ACCTT intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for USP36 Gene

Variant ID Type Subtype PubMed ID
nsv908893 CNV Loss 21882294
nsv908894 CNV Loss 21882294

Variation tolerance for USP36 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.63; 89.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP36 Gene

HapMap Linkage Disequilibrium report
USP36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP36 Gene

Disorders for USP36 Gene

Relevant External Links for USP36

Genetic Association Database (GAD)
USP36
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP36

No disorders were found for USP36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP36 Gene

Publications for USP36 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 67
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  3. The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc. (PMID: 25775507) Sun X.X. … Dai M.S. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. (PMID: 24912190) Ivatt R.M. … Whitworth A.J. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for USP36 Gene

Sources for USP36 Gene

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