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Aliases for USP35 Gene

Aliases for USP35 Gene

  • Ubiquitin Specific Peptidase 35 2 3 5
  • Ubiquitin-Specific-Processing Protease 35 4
  • Ubiquitin Specific Protease 35 2
  • Deubiquitinating Enzyme 35 4
  • Ubiquitin Thioesterase 35 4
  • EC 4
  • KIAA1372 4
  • USP34 4

External Ids for USP35 Gene

Previous GeneCards Identifiers for USP35 Gene

  • GC11P078122
  • GC11P077636
  • GC11P077626
  • GC11P077577
  • GC11P077899
  • GC11P074197

Summaries for USP35 Gene

GeneCards Summary for USP35 Gene

USP35 (Ubiquitin Specific Peptidase 35) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include binding and cysteine-type peptidase activity. An important paralog of this gene is USP38.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP35 Gene

Genomics for USP35 Gene

Regulatory Elements for USP35 Gene

Enhancers for USP35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F078138 1.1 ENCODE 10.9 -49.0 -49046 2.6 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 KCTD21-AS1 KCTD21 USP35 THRSP INTS4 ALG8
GH11F078156 1 ENCODE 11.5 -32.2 -32162 1.0 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 FOS SP5 USP35 KCTD21 INTS4 GC11P078155 PIR47143 GC11M078165
GH11F078256 1.1 Ensembl ENCODE 10.2 +68.3 68289 1.4 HDAC1 ARNT RAD21 FOS ZBTB2 CEBPB REST NR2F2 CREB3 TFDP1 ENSG00000254649 GAB2 KCTD21 USP35 NARS2 PIR56737 LOC105369402
GH11F078166 0.7 ENCODE 12.2 -21.6 -21648 1.3 ZNF639 LEF1 ESRRA L3MBTL2 TAL1 NR4A1 ZBTB11 SIN3A ARID1B CREB3 KCTD21-AS1 ALG8 KCTD21 USP35 NDUFC2 THRSP PIR40351 GC11M078165
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around USP35 on UCSC Golden Path with GeneCards custom track

Promoters for USP35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for USP35 Gene

78,188,812 bp from pter
78,217,644 bp from pter
28,833 bases
Plus strand

Genomic View for USP35 Gene

Genes around USP35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP35 Gene

Proteins for USP35 Gene

  • Protein details for USP35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 35
    Protein Accession:

    Protein attributes for USP35 Gene

    1018 amino acids
    Molecular mass:
    113405 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA92610.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for USP35 Gene


neXtProt entry for USP35 Gene

Post-translational modifications for USP35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for USP35 Gene

Domains & Families for USP35 Gene

Gene Families for USP35 Gene

Protein Domains for USP35 Gene

Suggested Antigen Peptide Sequences for USP35 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP35: view

Function for USP35 Gene

Molecular function for USP35 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme Numbers (IUBMB) for USP35 Gene

Gene Ontology (GO) - Molecular Function for USP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 14715245
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP35: view
genes like me logo Genes that share phenotypes with USP35: view

Animal Model Products

miRNA for USP35 Gene

miRTarBase miRNAs that target USP35

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP35 Gene

Localization for USP35 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP35 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP35 Gene

Pathways & Interactions for USP35 Gene

genes like me logo Genes that share pathways with USP35: view

Pathways by source for USP35 Gene

1 Qiagen pathway for USP35 Gene

Gene Ontology (GO) - Biological Process for USP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IDA 14715245
genes like me logo Genes that share ontologies with USP35: view

No data available for SIGNOR curated interactions for USP35 Gene

Drugs & Compounds for USP35 Gene

(1) Drugs for USP35 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with USP35: view

Transcripts for USP35 Gene

Unigene Clusters for USP35 Gene

Ubiquitin specific peptidase 35:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP35 Gene

No ASD Table

Relevant External Links for USP35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USP35 Gene

Protein differential expression in normal tissues from HIPED for USP35 Gene

This gene is overexpressed in Platelet (36.3) and Liver, secretome (25.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for USP35 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP35 Gene:


SOURCE GeneReport for Unigene cluster for USP35 Gene:


mRNA Expression by UniProt/SwissProt for USP35 Gene:

Tissue specificity: Expressed in testis, pancreas and skeletal muscle.
genes like me logo Genes that share expression patterns with USP35: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for USP35 Gene

Orthologs for USP35 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia USP35 34
  • 99.09 (n)
(Canis familiaris)
Mammalia USP35 34 35
  • 88.35 (n)
(Bos Taurus)
Mammalia USP35 35
  • 88 (a)
(Mus musculus)
Mammalia Usp35 34 16 35
  • 85.93 (n)
(Rattus norvegicus)
Mammalia Usp35 34
  • 85.73 (n)
(Monodelphis domestica)
Mammalia USP35 35
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 34 (a)
(Gallus gallus)
Aves USP35 34
  • 67.41 (n)
-- 35
  • 64 (a)
-- 35
  • 54 (a)
(Anolis carolinensis)
Reptilia USP35 35
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia usp35 34
  • 63.47 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010080 34
  • 48.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8830 34 35
  • 48.52 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP13 35
  • 17 (a)
UBP9 35
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
Species where no ortholog for USP35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for USP35 Gene

Gene Tree for USP35 (if available)
Gene Tree for USP35 (if available)

Paralogs for USP35 Gene

Paralogs for USP35 Gene

(1) SIMAP similar genes for USP35 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with USP35: view

Variants for USP35 Gene

Sequence variations from dbSNP and Humsavar for USP35 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1006441 -- 78,221,080(+) GGCTC(C/G)TGCTC intron-variant, nc-transcript-variant
rs1007837 -- 78,230,030(+) ATCTC(C/T)GCCAA intron-variant
rs1046780 -- 78,215,723(-) CACAA(C/T)GGGGT intron-variant, utr-variant-3-prime
rs10532208 -- 78,214,884(+) GACTG(-/ACTT)ACTTA intron-variant, downstream-variant-500B
rs1055248 -- 78,214,527(+) TTCCT(C/T)GTGAA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for USP35 Gene

Variant ID Type Subtype PubMed ID
esv33345 CNV gain 17666407
nsv1036793 CNV gain 25217958
nsv1127212 CNV deletion 24896259
nsv1132346 CNV duplication 24896259
nsv516503 CNV loss 19592680
nsv520740 CNV gain 19592680
nsv527066 CNV gain 19592680
nsv826000 CNV loss 20364138

Variation tolerance for USP35 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.60; 93.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP35 Gene

Disorders for USP35 Gene

Relevant External Links for USP35

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for USP35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP35 Gene

Publications for USP35 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 3 4 64
  3. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 64
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
  5. Deubiquitinating enzymes regulate PARK2-mediated mitophagy. (PMID: 25915564) Wang Y. … McQuibban G.A. (Autophagy 2015) 3 64

Products for USP35 Gene

Sources for USP35 Gene

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