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Aliases for USP35 Gene

Aliases for USP35 Gene

  • Ubiquitin Specific Peptidase 35 2 3 5
  • Ubiquitin-Specific-Processing Protease 35 4
  • Ubiquitin Specific Protease 35 2
  • Deubiquitinating Enzyme 35 4
  • Ubiquitin Thioesterase 35 4
  • EC 3.4.19.12 4
  • KIAA1372 4
  • USP34 4

External Ids for USP35 Gene

Previous GeneCards Identifiers for USP35 Gene

  • GC11P078122
  • GC11P077636
  • GC11P077626
  • GC11P077577
  • GC11P077899
  • GC11P074197

Summaries for USP35 Gene

Entrez Gene Summary for USP35 Gene

  • This gene encodes a member of the peptidase C19 family of ubiquitin-specific proteases. These deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin proteins from other proteins. The encoded protein associates with polarized mitochondria and has been shown to inhibit NF-kappa B activation and delay PARK2-mediated degradation of mitochondria. Expression of this gene is upregulated by the let-7a microRNA and reduced expression has been observed in human tumor tissues. [provided by RefSeq, Jul 2017]

GeneCards Summary for USP35 Gene

USP35 (Ubiquitin Specific Peptidase 35) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include binding and cysteine-type peptidase activity. An important paralog of this gene is USP38.

Additional gene information for USP35 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP35 Gene

Genomics for USP35 Gene

Regulatory Elements for USP35 Gene

Enhancers for USP35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H078185 2 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -0.9 -937 5 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B RPL21P95 LOC101928865 INTS4 ENSG00000255449 KCTD21-AS1 ALG8 USP35 RSF1 PIR40351
GH11H078256 1.4 Ensembl ENCODE dbSUPER 10.2 +68.3 68326 1 HDAC1 RB1 ARNT RAD21 TCF12 ZNF766 ELK1 ATF7 ZBTB2 CEBPB ENSG00000254649 GAB2 USP35 KCTD21 NARS2 PIR56737 LOC105369402
GH11H078192 1.2 Ensembl ENCODE dbSUPER 11.9 +4.1 4066 1 RFX1 SAP130 TAL1 NRF1 E2F5 REST THRB YY1 ZFHX2 POLR2A USP35 KCTD21-AS1 ALG8 KCTD21 PIR47261
GH11H078166 1 ENCODE dbSUPER 12.3 -21.6 -21648 1 ZNF639 LEF1 CAVIN1 L3MBTL2 HINFP NR4A1 TAL1 ZBTB11 E2F5 ZNF592 KCTD21-AS1 ALG8 KCTD21 USP35 NDUFC2 THRSP GC11M078165 PIR40351
GH11H078138 1.1 ENCODE 10.9 -49.0 -49046 2 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF143 ZNF207 KCTD21-AS1 KCTD21 USP35 THRSP INTS4 ALG8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around USP35 on UCSC Golden Path with GeneCards custom track

Promoters for USP35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000042541 -112 1801 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for USP35 Gene

Chromosome:
11
Start:
78,188,812 bp from pter
End:
78,217,644 bp from pter
Size:
28,833 bases
Orientation:
Plus strand

Genomic View for USP35 Gene

Genes around USP35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP35 Gene

Proteins for USP35 Gene

  • Protein details for USP35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2H5-UBP35_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 35
    Protein Accession:
    Q9P2H5

    Protein attributes for USP35 Gene

    Size:
    1018 amino acids
    Molecular mass:
    113405 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92610.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for USP35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP35 Gene

Post-translational modifications for USP35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for USP35 Gene

Domains & Families for USP35 Gene

Gene Families for USP35 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for USP35 Gene

Suggested Antigen Peptide Sequences for USP35 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2H5

UniProtKB/Swiss-Prot:

UBP35_HUMAN :
  • Belongs to the peptidase C19 family.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP35: view

Function for USP35 Gene

Molecular function for USP35 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme Numbers (IUBMB) for USP35 Gene

Gene Ontology (GO) - Molecular Function for USP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 14715245
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP35: view
genes like me logo Genes that share phenotypes with USP35: view

Animal Model Products

CRISPR Products

miRNA for USP35 Gene

miRTarBase miRNAs that target USP35

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for USP35
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP35 Gene

Localization for USP35 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP35 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP35 Gene

Pathways & Interactions for USP35 Gene

genes like me logo Genes that share pathways with USP35: view

Pathways by source for USP35 Gene

1 Qiagen pathway for USP35 Gene

Gene Ontology (GO) - Biological Process for USP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IDA 14715245
genes like me logo Genes that share ontologies with USP35: view

No data available for SIGNOR curated interactions for USP35 Gene

Drugs & Compounds for USP35 Gene

(1) Drugs for USP35 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with USP35: view

Transcripts for USP35 Gene

Unigene Clusters for USP35 Gene

Ubiquitin specific peptidase 35:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for USP35
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for USP35 Gene

No ASD Table

Relevant External Links for USP35 Gene

GeneLoc Exon Structure for
USP35
ECgene alternative splicing isoforms for
USP35

Expression for USP35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP35 Gene

Protein differential expression in normal tissues from HIPED for USP35 Gene

This gene is overexpressed in Platelet (36.3) and Liver, secretome (25.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for USP35 Gene



NURSA nuclear receptor signaling pathways regulating expression of USP35 Gene:

USP35

SOURCE GeneReport for Unigene cluster for USP35 Gene:

Hs.531249

mRNA Expression by UniProt/SwissProt for USP35 Gene:

Q9P2H5-UBP35_HUMAN
Tissue specificity: Expressed in testis, pancreas and skeletal muscle.

Evidence on tissue expression from TISSUES for USP35 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with USP35: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP35 Gene

Orthologs for USP35 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP35 33
  • 99.09 (n)
dog
(Canis familiaris)
Mammalia USP35 33 34
  • 88.35 (n)
cow
(Bos Taurus)
Mammalia USP35 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp35 33 16 34
  • 85.93 (n)
rat
(Rattus norvegicus)
Mammalia Usp35 33
  • 85.73 (n)
oppossum
(Monodelphis domestica)
Mammalia USP35 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 34 (a)
ManyToMany
chicken
(Gallus gallus)
Aves USP35 33
  • 67.41 (n)
-- 34
  • 64 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia USP35 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp35 33
  • 63.47 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010080 33
  • 48.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8830 33 34
  • 48.52 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP13 34
  • 17 (a)
ManyToMany
UBP9 34
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToMany
Species where no ortholog for USP35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for USP35 Gene

ENSEMBL:
Gene Tree for USP35 (if available)
TreeFam:
Gene Tree for USP35 (if available)

Paralogs for USP35 Gene

Paralogs for USP35 Gene

(1) SIMAP similar genes for USP35 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with USP35: view

Variants for USP35 Gene

Sequence variations from dbSNP and Humsavar for USP35 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000063506 -- 78,206,320(+) TCTGT(G/T)GGGGT intron-variant
rs1000116380 -- 78,202,543(+) ACTGA(A/G)AATGA intron-variant
rs1000167572 -- 78,229,964(+) CACTT(A/G)CTTAA intron-variant
rs1000276307 -- 78,214,864(+) TGTAA(C/G)TAAAC intron-variant, downstream-variant-500B
rs1000309332 -- 78,229,764(+) CAAAC(A/C)AAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP35 Gene

Variant ID Type Subtype PubMed ID
esv33345 CNV gain 17666407
nsv1036793 CNV gain 25217958
nsv1127212 CNV deletion 24896259
nsv1132346 CNV duplication 24896259
nsv516503 CNV loss 19592680
nsv520740 CNV gain 19592680
nsv527066 CNV gain 19592680
nsv826000 CNV loss 20364138

Variation tolerance for USP35 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.60; 93.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP35 Gene

Disorders for USP35 Gene

Relevant External Links for USP35

Genetic Association Database (GAD)
USP35
Human Genome Epidemiology (HuGE) Navigator
USP35
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP35

No disorders were found for USP35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP35 Gene

Publications for USP35 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V … López-Otín C (Biochemical and biophysical research communications 2004) 3 4 60
  3. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3 60
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 60
  5. USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA. (PMID: 27801882) Zhang M … Zhong B (Cell research 2016) 3 60

Products for USP35 Gene

Sources for USP35 Gene

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