USP35 Gene
protein-coding GIFtS: 46
GCID: GC11P077899
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ubiquitin specific peptidase 35(Previous name: ubiquitin specific protease 35 )
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Aliases
for USP35 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 351 2 | | Ubiquitin-Specific-Processing Protease 352 3 | | Ubiquitin Specific Protease 351 2 | | Ubiquitin Carboxyl-Terminal Hydrolase 352 | | KIAA13721 3 | | Ubiquitin Thiolesterase 352 | | Deubiquitinating Enzyme 352 3 | | EC 3.4.19.123 | | Ubiquitin Thioesterase 352 3 | | USP343 |
Export aliases for USP35 gene to outside databasesPrevious GC identifers: GC11P078122 GC11P077636 GC11P077626 GC11P077577 GC11P074197 |
Summaries
for USP35 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for USP35 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP35 gene promoter:
NF-1/L NF-1 p53 AP-4 Nkx2-5 C/EBPalpha Egr-4 SEF-1 (1) Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP35
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP35 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q14.1 Ensembl cytogenetic band: 11q14.1 HGNC cytogenetic band: 11q13.4USP35 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P077899: view genomic region
(about GC identifiers)
Start:
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77,899,858 bp from pter |
End:
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77,925,757 bp from pter |
Size:
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25,900 bases |
Orientation:
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plus strand |
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Proteins
for USP35 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP35_HUMAN, Q9P2H5 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 35 Size: 1018 amino acids; 113405 Da
Sequence caution: Sequence=BAA92610.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Alternative splicing: 2 isoforms: Q9P2H5-1 Q9P2H5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for USP35: NX_Q9P2H5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P2H5
USP35 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065849.1
ENSEMBL proteins: ENSP00000435468 ENSP00000436001 ENSP00000431876 ENSP00000436253 ENSP00000434942 ENSP00000400825
Human Recombinant Protein Products:
USP35 Antibody Products:
Assay Products for USP35: |
Protein
Domains /
Families
for USP35 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP35 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P2H5ProtoNet protein and cluster: Q9P2H5 1 Blocks protein family: IPB001394 Ubiquitin thiolesterase
UniProtKB/Swiss-Prot: UBP35_HUMAN, Q9P2H5Similarity: Belongs to the peptidase C19 family |
Function
for USP35 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBP35_HUMAN, Q9P2H5Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)Enzyme Number (IUBMB): EC 3.4.19.121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP35 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP35
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: USP35 (NM_020798) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP35 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP35 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP35 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004221 | ubiquitin thiolesterase activity |
IEA | -- | | GO:0008234 | cysteine-type peptidase activity |
IEA | -- |
USP35 for ontologies About GeneDecksing
|
Pathways & Interactions
for USP35 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Ubiquitin-Proteasome Dependent Proteolysis | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP35
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP35
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- |
USP35 for ontologies About GeneDecksing
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Drugs & Compounds
for USP35 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USP35
1 HMDB Compound for USP35 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Water | Dihydrogen oxide (see all 2) | 7732-18-5 | -- |
Search CenterWatch for drugs/clinical trials and news about USP35 / UBP35
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Transcripts
for USP35 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP35 gene: NM_020798.2 Unigene Cluster for USP35: Ubiquitin specific peptidase 35 Hs.531249 [show with all ESTs]Unigene Representative Sequence: NM_0207988 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000530267 ENST00000530535 ENST00000528910 ENST00000529308(uc001oze.2 uc021qny.1 uc001ozc.3 uc010rsp.2 uc001ozd.3)
ENST00000530546 ENST00000526425(uc001ozf.3) ENST00000530521 ENST00000441408
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP35 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP35
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: USP35 (NM_020798) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP35 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP35 |
Additional cDNA sequence: AB037793.1 AJ586137.1 AK056231.1 AK301048.1 AK307875.1 BC131489.1 3 DOTS entries: DT.430726 DT.95366881 DT.91896906 24/37 AceView cDNA sequences (see all 37): BQ948121 AJ586137 AB037793 CA389703 BM068765 AA977762 BM718319 AA403190 CK904610 R50743 BU741911 AK056231 CA445653 BU632442 BM147701 BX104206 AI826092 AI000900 BX478131 CB129491 BE867644 BM149991 AI694095 BM054748
GeneLoc Exon Structure
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Expression
for USP35 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP35 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCATAAATA
About this image
See USP35 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP35
SOURCE GeneReport for Unigene cluster: Hs.531249
UniProtKB/Swiss-Prot: UBP35_HUMAN, Q9P2H5Tissue specificity: Expressed in testis, pancreas and skeletal muscle
SABiosciences Custom PCR Arrays for USP35
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP35
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP35 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP35 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP35 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP35 |
Orthologs
for USP35 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for USP35 gene from 3/17 species (see all 17) About this table
ENSEMBL Gene Tree for USP35 (if available)
TreeFam Gene Tree for USP35 (if available) |
Paralogs
for USP35 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP35 gene
- USP122 USP382 USP462 USP12
1 SIMAP similar gene for USP35 using alignment to 6 protein entries: UBP35_HUMAN (see all proteins):USP38
USP35 for paralogs About GeneDecksing
|
Genomic Variants
for USP35 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP35 (77899858 - 77925757 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for USP35
2 CNVs: 6942 48885 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP35 |
|
Disorders
/ Diseases
for USP35 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP35 for disorders About GeneDecksing
2  diseases for USP35: About MalaCardshepatitis b hepatitis
Human Genome Epidemiology (HuGE) Navigator: USP35 (4 documents)
Export disorders for USP35 gene to outside databases
|
Publications
for USP35 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USP35 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with USP35) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (2004)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
- Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
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External Searches for USP35 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing USP35 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USP35 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing USP35 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for USP35 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for USP35 gene:
Search GeneIP for patents involving USP35
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for USP35 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for USP35 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP35 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP35 | | | OriGene Protein Over-expression Lysate for USP35 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for USP35 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP35 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP35 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for USP35 | | OriGene Custom Protein Services for USP35 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP35 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP35 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP35 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP35 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP35 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP35 |
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 |  |  |  | |
| | | | Search Tocris compounds for USP35 |
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 | | | USP35 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP35 |
|  |  |  | | | | Search ThermoFisher Antibodies for USP35 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP35 |
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