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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

USP34 Gene

protein-coding   GIFtS: 54
GCID: GC02M061414

Ubiquitin Specific Peptidase 34

(Previous name: ubiquitin specific protease 34)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Specific Peptidase 341 2     Ubiquitin Thiolesterase 342
Ubiquitin Specific Protease 341 2     EC 3.4.19.123
Deubiquitinating Enzyme 342 3     KIAA05703
Ubiquitin Thioesterase 342 3     KIAA07293
Ubiquitin-Specific-Processing Protease 342 3     EC 3.1.2.158
Ubiquitin Carboxyl-Terminal Hydrolase 342     

External Ids:    HGNC: 200661   Entrez Gene: 97362   Ensembl: ENSG000001154647   OMIM: 6152955   UniProtKB: Q70CQ23   

Export aliases for USP34 gene to outside databases

Previous GC identifers: GC02M061372 GC02M061389 GC02M061327 GC02M061155


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for USP34 Gene: 
USP34 (ubiquitin specific peptidase 34) is a protein-coding gene. Diseases associated with USP34 include ataxia telangiectasia, and ataxia. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP24.

UniProtKB/Swiss-Prot: UBP34_HUMAN, Q70CQ2
Function: Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a
regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the
beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear
accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes
and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin
precursors as well as that of ubiquitinated proteins

Gene Wiki entry for USP34 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the USP34 gene promoter:
         TBP   SRF   RREB-1   SRF (504 AA)   MIF-1   AP-4   C/EBPalpha   CHOP-10   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP34 promoter sequence
   Search SABiosciences Chromatin IP Primers for USP34

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p15   Ensembl cytogenetic band:  2p15   HGNC cytogenetic band: 2p16.1-p15

USP34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP34 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M061414:  view genomic region     (about GC identifiers)

Start:
61,414,590 bp from pter      End:
61,697,904 bp from pter
Size:
283,315 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBP34_HUMAN, Q70CQ2 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 34  
Size: 3546 amino acids; 404233 Da
Subunit: Interacts with AXIN1 and AXIN2
Sequence caution: Sequence=AAI07762.1; Type=Frameshift; Positions=3200; Sequence=BAA25496.2; Type=Erroneous
initiation; Sequence=BAG54261.1; Type=Erroneous initiation;
Secondary accessions: A8MWD0 B3KWU9 O60316 O94834 Q3B777 Q6P6C9 Q7L8P6 Q8N3T9 Q8TBW2 Q9UGA1
Alternative splicing: 3 isoforms:  Q70CQ2-1   Q70CQ2-2   Q70CQ2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP34: NX_Q70CQ2

Explore proteomics data for USP34 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q70CQ2

  • 2 DME Specific Peptides for USP34 (Q70CQ2)
     GSSGPGS  IQQLYMIP 

    USP34 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    USP34 Protein Expression
    REFSEQ proteins: NP_055524.3  
    ENSEMBL proteins: 
     ENSP00000398960   ENSP00000381577   ENSP00000398489   ENSP00000410559   ENSP00000388129  

    Human Recombinant Protein Products for USP34: 
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    Cloud-Clone Corp. Proteins for USP34 


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    Cloud-Clone Corp. CLIAs for USP34


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    USP: Ubiquitin-specific peptidases

    3 InterPro protein domains:
     IPR001394 Peptidase_C19
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q70CQ2

    ProtoNet protein and cluster: Q70CQ2

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP34_HUMAN, Q70CQ2
    Similarity: Belongs to the peptidase C19 family


    USP34 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP34_HUMAN, Q70CQ2
    Function: Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a
    regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the
    beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear
    accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes
    and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin
    precursors as well as that of ubiquitinated proteins
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IMP--
    GO:0004221ubiquitin thiolesterase activity IDA--
    GO:0004843ubiquitin-specific protease activity IDA--
    GO:0005488binding ----
    GO:0005515protein binding IPI--
         
    USP34 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for USP34:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for USP34 
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    miRNA
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    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate USP34 (see all 40):
    hsa-miR-1197 hsa-miR-300 hsa-miR-29a hsa-miR-938 hsa-let-7a-2* hsa-miR-578 hsa-miR-218 hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidUSP34 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP34


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for USP34 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP34
        Ubiquitin-Proteasome Dependent Proteolysis


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP34

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for USP34 (Q70CQ23 ENSP000003815774) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATMQ133153, ENSP000002786164I2D: score=1 STRING: ENSP00000278616
    PRKCHP247233I2D: score=2 
    GRB10Q133223I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    SIRT7ENSP000003294664STRING: ENSP00000329466
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0071108protein K48-linked deubiquitination IDA--
    GO:0090263positive regulation of canonical Wnt receptor signaling pathway IDA--

    USP34 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for USP34 (UBP34)

    Search CenterWatch for drugs/clinical trials and news about USP34 / UBP34

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for USP34 gene: 
    NM_014709.3  

    Unigene Cluster for USP34:

    Ubiquitin specific peptidase 34
    Hs.644708  [show with all ESTs]
    Unigene Representative Sequence: NM_014709
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000411912(uc002sbd.3) ENST00000398571(uc002sbe.3) ENST00000436269
    ENST00000492604 ENST00000463046 ENST00000490552 ENST00000498268 ENST00000476716
    ENST00000467128 ENST00000472689 ENST00000472706 ENST00000490527 ENST00000483672
    ENST00000482250 ENST00000487547 ENST00000468703 ENST00000453734(uc002sbf.3)
    ENST00000492882

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat USP34
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate USP34 (see all 40):
    hsa-miR-1197 hsa-miR-300 hsa-miR-29a hsa-miR-938 hsa-let-7a-2* hsa-miR-578 hsa-miR-218 hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidUSP34 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP34
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP34 (NM_014709)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP34
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat USP34
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat USP34
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP34
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP34

    Additional mRNA sequence: 

    AB018272.1 AJ586138.1 AK001193.1 AK022637.1 AK023171.1 AK125898.1 AL050092.1 AL831918.1 
    BC022783.1 BC062325.1 BC107761.1 

    24/32 DOTS entries (see all 32):

    DT.454582  DT.100029825  DT.310893  DT.100655333  DT.40259640  DT.120949935  DT.91761718  DT.211043 
    DT.40123106  DT.120949959  DT.121643738  DT.120950004  DT.120949739  DT.101976383  DT.40215551  DT.100862210 
    DT.100640061  DT.100860192  DT.120949865  DT.120949906  DT.91762447  DT.100804323  DT.120949747  DT.425742 

    24/407 AceView cDNA sequences (see all 407):

    W80725 AL831918 BX414262 AL050092 AA026071 AI620120 BU621420 BE465805 
    AA295008 AA284590 AW188370 H90424 BM904747 AA009698 AU131420 Z42541 
    AB011142 AV646092 BE349953 AI348308 BM850054 NM_014709 BQ006341 AA769124 

    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for USP34 (see all 21)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^
    SP1:                                                                                                                                                        -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^
    SP1:              -           -                                                                                   -                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 41a · 41b ^ 42 ^ 43 ^ 44a · 44b · 44c ^ 45a · 45b ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^ 51a · 51b ^ 52 ^ 53 ^ 54 ^ 55 ^ 56a · 56b ^ 57 ^ 58a · 58b ^ 59a ·
    SP1:                                                                                                                                                            
    SP2:  -                       -                       -                                                                       -                 -     -     -   
    SP3:                                                                                                        -     -           -                 -     -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 59b ^ 60a · 60b · 60c · 60d ·
    SP1:                              
    SP2:        -                     
    SP3:        -                     
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for USP34

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    USP34 expression in normal human tissues (normalized intensities)      USP34 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGATTGAT
    USP34 Expression
    About this image


    USP34 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Double Positive Thymocytes Thymus
             neutrophils   
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Uterus (Reproductive System)
             endometrial endothelial cell   

    See USP34 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for USP34

    SOURCE GeneReport for Unigene cluster: Hs.644708

    UniProtKB/Swiss-Prot: UBP34_HUMAN, Q70CQ2
    Tissue specificity: Expressed in brain at low level

        SABiosciences Expression via Pathway-Focused PCR Array including USP34: 
              Parkinson's Disease in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for USP34 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp341 , 5 ubiquitin specific peptidase 341, 5 92.36(n)1
    97.57(a)1
      11 (14.29 cM)5
    178471  NM_001190401.21  NP_001177330.21 
     233069165 
    chicken
    (Gallus gallus)
    Aves USP341 ubiquitin specific peptidase 34 84.69(n)
    93.76(a)
      421193  NM_001199416.1  NP_001186345.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP346
    ubiquitin specific peptidase 34
    93(a)
    1 ↔ 1
    GL343523.1(181595-314812)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.240282 Xenopus laevis transcribed sequence with moderate similarity more 78.5(n)    BX843453.1 
    zebrafish
    (Danio rerio)
    Actinopterygii usp341 ubiquitin specific peptidase 34 71.09(n)
    84.07(a)
      562779  XM_002660563.3  XP_002660609.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG57941 CG5794 51.21(n)
    46.51(a)
      42935  NM_143018.3  NP_651275.1 


    ENSEMBL Gene Tree for USP34 (if available)
    TreeFam Gene Tree for USP34 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for USP34 gene
    USP242  USP72  USP402  USP182  USP472  USP9Y2  USP9X2  USP482  
    USP412  

    USP34 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for USP34
    PGOHUM00000248354


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6462 SNPs in USP34 are shown (see all 6462)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs358073141,2
    C--61361972(+) GCTAA-/T/TTT 
            
    TTTTT
    1 -- int11NA 2
    rs114170171,2
    C--61391009(+) AATAC-/AAAAAA 1 -- int1 trp31Minor allele frequency- A:0.50NA 2
    rs2013564281,2
    C--61415230(+) CTACAC/TCTAAT 1 -- ut311Minor allele frequency- T:0.00EU 1319
    rs1481540081,2
    C--61415274(+) TCCTTA/GTGACG 2 T I mis10--------
    rs1840806171,2
    C--61415311(+) ACACAG/AGGTAT 2 /L syn11Minor allele frequency- A:0.00EU 1321
    rs2013797211,2
    C--61415328(+) TGTCAT/CGTTGC 2 /H /R mis11Minor allele frequency- C:0.00EU 1321
    rs1886148041,2
    C,F--61415378(+) AGAGAT/GAAAGC 2 /L /F mis11Minor allele frequency- G:0.00EU 1323
    rs1921820201,2
    C--61415392(+) CTCAGA/GGTCCT 2 P S mis10--------
    rs2008127951,2
    C--61415397(+) GGTCCC/TGGGAG 2 Q R mis10--------
    rs1438425511,2
    C--61415419(+) GCCATC/GACAGC 2 H D mis10--------

    HapMap Linkage Disequilibrium report for USP34 (61414590 - 61664590 bp, first 250kb of USP34)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for USP34 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2666095CNV Deletion23128226
    nsv874228CNV Loss21882294
    dgv4158n71CNV Loss21882294
    nsv528479CNV Loss19592680
    nsv483028CNV Loss15286789
    nsv874213CNV Loss21882294
    nsv874226CNV Loss21882294
    dgv4157n71CNV Loss21882294
    nsv874227CNV Gain21882294
    nsv874212CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615295    OMIM disorders: --

    4 diseases for USP34:    About MalaCards
    ataxia telangiectasia    ataxia    crohn's disease    parkinson's disease


    USP34 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): USP34
    Human Genome Epidemiology (HuGE) Navigator: USP34 (1 document)

    Export disorders for USP34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for USP34 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with USP34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling. (PubMed id 21383061)1, 2 Lui T.T.... Angers S. (2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (2004)
    6. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    8. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (1998)
    9. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)
    10. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9736 HGNC: 20066 AceView: USP34 Ensembl:ENSG00000115464 euGenes: HUgn9736
    ECgene: USP34 H-InvDB: USP34

    (According to HUGE)
    About This Section
    HUGE: KIAA0570 KIAA0729

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for USP34 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for USP34 gene:
    Search GeneIP for patents involving USP34

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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