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Aliases for USP34 Gene

Aliases for USP34 Gene

  • Ubiquitin Specific Peptidase 34 2 3 5
  • Ubiquitin-Specific-Processing Protease 34 4
  • Ubiquitin Specific Protease 34 2
  • Deubiquitinating Enzyme 34 4
  • Ubiquitin Thioesterase 34 4
  • EC 3.4.19.12 4
  • EC 3.1.2.15 61
  • KIAA0570 4
  • KIAA0729 4

External Ids for USP34 Gene

Previous GeneCards Identifiers for USP34 Gene

  • GC02M061372
  • GC02M061389
  • GC02M061327
  • GC02M061414

Summaries for USP34 Gene

GeneCards Summary for USP34 Gene

USP34 (Ubiquitin Specific Peptidase 34) is a Protein Coding gene. Among its related pathways are Signaling by Wnt and Deubiquitination. GO annotations related to this gene include binding and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP9X.

UniProtKB/Swiss-Prot for USP34 Gene

  • Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.

Gene Wiki entry for USP34 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP34 Gene

Genomics for USP34 Gene

Regulatory Elements for USP34 Gene

Enhancers for USP34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G061424 1.3 FANTOM5 Ensembl ENCODE 15.5 +44.9 44946 2.3 CTCF SAP130 ARID4B ZNF384 ZNF48 RAD21 CHAMP1 GATAD1 ZNF143 ZNF207 AHSA2 LOC339803 USP34 CCT4 COMMD1 SNORA70B
GH02G061468 1.7 FANTOM5 ENCODE dbSUPER 8.1 +0.2 165 4.7 HDGF HNRNPUL1 PKNOX1 FOXA2 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 LOC339803 AHSA2 USP34 PUS10 SNORA70B
GH02G061434 0.8 Ensembl ENCODE 12.8 +36.1 36069 1.0 MAX PRDM1 MYC SPI1 LOC339803 USP34 RNU6-1145P AHSA2 SNORA70B
GH02G061432 0.8 ENCODE 12.8 +37.6 37628 1.8 TBP ELF3 CTCF FOXA2 ZNF644 RAD21 YY1 RARA FOSL1 SCRT2 AHSA2 USP34 RNU6-1145P SNORA70B
GH02G061423 0.6 ENCODE 12.9 +46.8 46829 0.2 FOXA2 MNT DPF2 FOXA1 FOSL1 GATA3 NFIC GATA2 FOS LOC339803 USP34 CCT4 COMMD1 SNORA70B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around USP34 on UCSC Golden Path with GeneCards custom track

Promoters for USP34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000117668 -31 3201 HDGF HNRNPUL1 PKNOX1 FOXA2 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZBTB7B

Genomic Location for USP34 Gene

Chromosome:
2
Start:
61,187,455 bp from pter
End:
61,470,769 bp from pter
Size:
283,315 bases
Orientation:
Minus strand

Genomic View for USP34 Gene

Genes around USP34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP34 Gene

Proteins for USP34 Gene

  • Protein details for USP34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70CQ2-UBP34_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 34
    Protein Accession:
    Q70CQ2
    Secondary Accessions:
    • A8MWD0
    • B3KWU9
    • O60316
    • O94834
    • Q3B777
    • Q6P6C9
    • Q7L8P6
    • Q8N3T9
    • Q8TBW2
    • Q9UGA1

    Protein attributes for USP34 Gene

    Size:
    3546 amino acids
    Molecular mass:
    404233 Da
    Quaternary structure:
    • Interacts with AXIN1 and AXIN2.
    SequenceCaution:
    • Sequence=AAI07762.1; Type=Frameshift; Positions=3200; Evidence={ECO:0000305}; Sequence=BAA25496.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG54261.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for USP34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP34 Gene

Selected DME Specific Peptides for USP34 Gene

Q70CQ2:
  • IQQLYMIP
  • GSSGPGS

Post-translational modifications for USP34 Gene

  • Ubiquitination at Lys484, Lys1574, Lys1968, Lys2100, posLast=21022102, and Lys2219
  • Modification sites at PhosphoSitePlus

Other Protein References for USP34 Gene

Domains & Families for USP34 Gene

Gene Families for USP34 Gene

Graphical View of Domain Structure for InterPro Entry

Q70CQ2

UniProtKB/Swiss-Prot:

UBP34_HUMAN :
  • Belongs to the peptidase C19 family.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP34: view

Function for USP34 Gene

Molecular function for USP34 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.

Enzyme Numbers (IUBMB) for USP34 Gene

Gene Ontology (GO) - Molecular Function for USP34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IMP 21383061
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 14715245
GO:0005515 protein binding IPI 21383061
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP34: view
genes like me logo Genes that share phenotypes with USP34: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP34 Gene

Localization for USP34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for USP34 gene
Compartment Confidence
cytosol 5
plasma membrane 2
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for USP34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with USP34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for USP34 Gene

Pathways & Interactions for USP34 Gene

genes like me logo Genes that share pathways with USP34: view

Pathways by source for USP34 Gene

Gene Ontology (GO) - Biological Process for USP34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016055 Wnt signaling pathway TAS --
GO:0016579 protein deubiquitination TAS,IEA --
GO:0071108 protein K48-linked deubiquitination IDA 21383061
genes like me logo Genes that share ontologies with USP34: view

No data available for SIGNOR curated interactions for USP34 Gene

Drugs & Compounds for USP34 Gene

No Compound Related Data Available

Transcripts for USP34 Gene

Unigene Clusters for USP34 Gene

Ubiquitin specific peptidase 34:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP34 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

ExUns: 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21:

ExUns: 41a · 41b ^ 42 ^ 43 ^ 44a · 44b · 44c ^ 45a · 45b ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^ 51a · 51b ^ 52 ^ 53 ^ 54 ^ 55 ^ 56a · 56b ^ 57 ^ 58a · 58b ^ 59a ·
SP1:
SP2: - - - - - - -
SP3: - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10:
SP11:
SP12:
SP13: -
SP14: -
SP15: - -
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21:

ExUns: 59b ^ 60a · 60b · 60c · 60d ·
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:
SP20: -
SP21:

Relevant External Links for USP34 Gene

GeneLoc Exon Structure for
USP34
ECgene alternative splicing isoforms for
USP34

Expression for USP34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for USP34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for USP34 Gene

This gene is overexpressed in Adrenal (12.4), Ovary (12.1), Placenta (8.9), and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for USP34 Gene



Protein tissue co-expression partners for USP34 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of USP34 Gene:

USP34

SOURCE GeneReport for Unigene cluster for USP34 Gene:

Hs.644708

mRNA Expression by UniProt/SwissProt for USP34 Gene:

Q70CQ2-UBP34_HUMAN
Tissue specificity: Expressed in brain at low level.

Evidence on tissue expression from TISSUES for USP34 Gene

  • Nervous system(4.9)
  • Intestine(4.3)
  • Kidney(4.3)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with USP34: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for USP34 Gene

Orthologs for USP34 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP34 34 35
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia USP34 34 35
  • 95.16 (n)
cow
(Bos Taurus)
Mammalia USP34 34 35
  • 94.79 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia USP34 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia USP34 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp34 34 16 35
  • 92.36 (n)
rat
(Rattus norvegicus)
Mammalia Usp34 34
  • 90.78 (n)
chicken
(Gallus gallus)
Aves USP34 34 35
  • 84.69 (n)
lizard
(Anolis carolinensis)
Reptilia USP34 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp34 34
  • 79.5 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24028 34
zebrafish
(Danio rerio)
Actinopterygii usp34 34 35
  • 71.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5794 34 35
  • 52.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003643 34
  • 51.86 (n)
worm
(Caenorhabditis elegans)
Secernentea T24B8.7 35
  • 16 (a)
OneToMany
Species where no ortholog for USP34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP34 Gene

ENSEMBL:
Gene Tree for USP34 (if available)
TreeFam:
Gene Tree for USP34 (if available)

Paralogs for USP34 Gene

Paralogs for USP34 Gene

Pseudogenes.org Pseudogenes for USP34 Gene

genes like me logo Genes that share paralogs with USP34: view

Variants for USP34 Gene

Sequence variations from dbSNP and Humsavar for USP34 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000004546 -- 61,443,881(+) TGTTG(A/C)TAATG intron-variant
rs1000006832 -- 61,343,264(+) TACTA(C/G)TCTTT intron-variant
rs1000034464 -- 61,276,134(+) CAAAA(C/T)TGGCA intron-variant
rs1000037184 -- 61,257,824(+) GAGCC(A/G)AGATC intron-variant
rs1000042820 -- 61,205,543(+) ATTTA(C/T)AATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP34 Gene

Variant ID Type Subtype PubMed ID
dgv1126e212 CNV loss 25503493
esv2666095 CNV deletion 23128226
esv2760616 CNV loss 21179565
esv3396738 CNV insertion 20981092
esv3583842 CNV loss 25503493
esv3583843 CNV loss 25503493
esv3583846 CNV loss 25503493
esv3591016 CNV loss 21293372
esv3591017 CNV loss 21293372
esv3591018 CNV loss 21293372
nsv1012689 CNV gain 25217958
nsv1014905 CNV gain 25217958
nsv1129395 OTHER inversion 24896259
nsv528479 CNV loss 19592680
nsv582118 CNV gain 21841781
nsv582119 CNV loss 21841781
nsv7313 OTHER inversion 18451855
nsv961408 CNV duplication 23825009

Variation tolerance for USP34 Gene

Residual Variation Intolerance Score: 0.0422% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.24; 70.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP34 Gene

Human Gene Mutation Database (HGMD)
USP34
SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP34 Gene

Disorders for USP34 Gene

Relevant External Links for USP34

Genetic Association Database (GAD)
USP34
Human Genome Epidemiology (HuGE) Navigator
USP34
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP34

No disorders were found for USP34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP34 Gene

Publications for USP34 Gene

  1. The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling. (PMID: 21383061) Lui T.T. … Angers S. (Mol. Cell. Biol. 2011) 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for USP34 Gene

Sources for USP34 Gene

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