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Aliases for USP34 Gene

Aliases for USP34 Gene

  • Ubiquitin Specific Peptidase 34 2 3 5
  • Ubiquitin-Specific-Processing Protease 34 4
  • Ubiquitin Specific Protease 34 2
  • Deubiquitinating Enzyme 34 4
  • Ubiquitin Thioesterase 34 4
  • EC 3.4.19.12 4
  • EC 3.1.2.15 63
  • KIAA0570 4
  • KIAA0729 4

External Ids for USP34 Gene

Previous GeneCards Identifiers for USP34 Gene

  • GC02M061372
  • GC02M061389
  • GC02M061327
  • GC02M061414

Summaries for USP34 Gene

GeneCards Summary for USP34 Gene

USP34 (Ubiquitin Specific Peptidase 34) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Wnt. GO annotations related to this gene include binding and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP41.

UniProtKB/Swiss-Prot for USP34 Gene

  • Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.

Gene Wiki entry for USP34 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP34 Gene

Genomics for USP34 Gene

Regulatory Elements for USP34 Gene

Promoters for USP34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around USP34 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP34 Gene

Chromosome:
2
Start:
61,187,455 bp from pter
End:
61,470,769 bp from pter
Size:
283,315 bases
Orientation:
Minus strand

Genomic View for USP34 Gene

Genes around USP34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP34 Gene

Proteins for USP34 Gene

  • Protein details for USP34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70CQ2-UBP34_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 34
    Protein Accession:
    Q70CQ2
    Secondary Accessions:
    • A8MWD0
    • B3KWU9
    • O60316
    • O94834
    • Q3B777
    • Q6P6C9
    • Q7L8P6
    • Q8N3T9
    • Q8TBW2
    • Q9UGA1

    Protein attributes for USP34 Gene

    Size:
    3546 amino acids
    Molecular mass:
    404233 Da
    Quaternary structure:
    • Interacts with AXIN1 and AXIN2.
    SequenceCaution:
    • Sequence=AAI07762.1; Type=Frameshift; Positions=3200; Evidence={ECO:0000305}; Sequence=BAA25496.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG54261.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for USP34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP34 Gene

Proteomics data for USP34 Gene at MOPED

Selected DME Specific Peptides for USP34 Gene

Post-translational modifications for USP34 Gene

  • Ubiquitination at Lys 484, Lys 1574, Lys 1968, Lys 2100, Lys 2102, and Lys 2219
  • Modification sites at PhosphoSitePlus

Other Protein References for USP34 Gene

Domains & Families for USP34 Gene

Gene Families for USP34 Gene

Protein Domains for USP34 Gene

Graphical View of Domain Structure for InterPro Entry

Q70CQ2

UniProtKB/Swiss-Prot:

UBP34_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP34: view

Function for USP34 Gene

Molecular function for USP34 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.

Enzyme Numbers (IUBMB) for USP34 Gene

genes like me logo Genes that share phenotypes with USP34: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP34 Gene

Localization for USP34 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP34 Gene COMPARTMENTS Subcellular localization image for USP34 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for USP34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IBA --
genes like me logo Genes that share ontologies with USP34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for USP34 Gene

Pathways & Interactions for USP34 Gene

genes like me logo Genes that share pathways with USP34: view

Pathways by source for USP34 Gene

Gene Ontology (GO) - Biological Process for USP34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071108 protein K48-linked deubiquitination IDA 21383061
genes like me logo Genes that share ontologies with USP34: view

No data available for SIGNOR curated interactions for USP34 Gene

Drugs & Compounds for USP34 Gene

No Compound Related Data Available

Transcripts for USP34 Gene

Unigene Clusters for USP34 Gene

Ubiquitin specific peptidase 34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP34 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

ExUns: 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21:

ExUns: 41a · 41b ^ 42 ^ 43 ^ 44a · 44b · 44c ^ 45a · 45b ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^ 51a · 51b ^ 52 ^ 53 ^ 54 ^ 55 ^ 56a · 56b ^ 57 ^ 58a · 58b ^ 59a ·
SP1:
SP2: - - - - - - -
SP3: - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10:
SP11:
SP12:
SP13: -
SP14: -
SP15: - -
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21:

ExUns: 59b ^ 60a · 60b · 60c · 60d ·
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:
SP20: -
SP21:

Relevant External Links for USP34 Gene

GeneLoc Exon Structure for
USP34
ECgene alternative splicing isoforms for
USP34

Expression for USP34 Gene

mRNA expression in normal human tissues for USP34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for USP34 Gene

This gene is overexpressed in Adrenal (12.4), Ovary (12.1), Placenta (8.9), and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP34 Gene



SOURCE GeneReport for Unigene cluster for USP34 Gene Hs.644708

mRNA Expression by UniProt/SwissProt for USP34 Gene

Q70CQ2-UBP34_HUMAN
Tissue specificity: Expressed in brain at low level.
genes like me logo Genes that share expression patterns with USP34: view

Protein tissue co-expression partners for USP34 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for USP34 Gene

Orthologs for USP34 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP34 36
  • 100 (a)
OneToOne
USP34 35
  • 99.78 (n)
  • 99.86 (a)
cow
(Bos Taurus)
Mammalia USP34 35
  • 94.79 (n)
  • 98.55 (a)
USP34 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP34 36
  • 99 (a)
OneToOne
USP34 35
  • 95.16 (n)
  • 98.76 (a)
mouse
(Mus musculus)
Mammalia Usp34 36
  • 97 (a)
OneToOne
Usp34 16
Usp34 35
  • 92.36 (n)
  • 97.57 (a)
oppossum
(Monodelphis domestica)
Mammalia USP34 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP34 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp34 35
  • 90.78 (n)
  • 96.67 (a)
chicken
(Gallus gallus)
Aves USP34 35
  • 84.69 (n)
  • 93.76 (a)
USP34 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP34 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24028 35
tropical clawed frog
(Silurana tropicalis)
Amphibia usp34 35
  • 79.5 (n)
  • 91.27 (a)
zebrafish
(Danio rerio)
Actinopterygii usp34 36
  • 79 (a)
OneToOne
usp34 35
  • 71.31 (n)
  • 84.33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003643 35
  • 51.86 (n)
  • 48.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5794 36
  • 38 (a)
OneToOne
CG5794 35
  • 52.42 (n)
  • 48.71 (a)
worm
(Caenorhabditis elegans)
Secernentea T24B8.7 36
  • 16 (a)
OneToMany
Species with no ortholog for USP34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP34 Gene

ENSEMBL:
Gene Tree for USP34 (if available)
TreeFam:
Gene Tree for USP34 (if available)

Paralogs for USP34 Gene

Paralogs for USP34 Gene

Pseudogenes.org Pseudogenes for USP34 Gene

genes like me logo Genes that share paralogs with USP34: view

Variants for USP34 Gene

Sequence variations from dbSNP and Humsavar for USP34 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6722430 - 61,348,173(+) CTGAC(A/G)TGCCT reference, missense
rs6723818 - 61,283,155(+) GAATA(A/C)GGAGA reference, missense
rs4386306 - 61,232,523(+) ACGAT(C/T)TAAAA reference, missense
rs796597 -- 61,453,925(-) CCTGT(C/T)TCTAC intron-variant
rs811372 -- 61,202,433(+) AGTCC(C/T)GAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP34 Gene

Variant ID Type Subtype PubMed ID
nsv874212 CNV Gain 21882294
nsv528479 CNV Loss 19592680
nsv874213 CNV Loss 21882294
dgv4157n71 CNV Loss 21882294
dgv4158n71 CNV Loss 21882294
nsv7313 OTHER Inversion 18451855
esv2666095 CNV Deletion 23128226
nsv874226 CNV Loss 21882294
nsv874227 CNV Gain 21882294
nsv483028 CNV Loss 15286789
nsv874228 CNV Loss 21882294

Variation tolerance for USP34 Gene

Residual Variation Intolerance Score: 0.0422% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.24; 70.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP34 Gene

HapMap Linkage Disequilibrium report
USP34
Human Gene Mutation Database (HGMD)
USP34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP34 Gene

Disorders for USP34 Gene

Relevant External Links for USP34

Genetic Association Database (GAD)
USP34
Human Genome Epidemiology (HuGE) Navigator
USP34
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP34

No disorders were found for USP34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP34 Gene

Publications for USP34 Gene

  1. The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling. (PMID: 21383061) Lui T.T. … Angers S. (Mol. Cell. Biol. 2011) 3 4 67
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3
  5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3

Products for USP34 Gene

Sources for USP34 Gene

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