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USP34 Gene

protein-coding   GIFtS: 58
GCID: GC02M061414

Ubiquitin Specific Peptidase 34

(Previous name: ubiquitin specific protease 34)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 341 2     Ubiquitin Carboxyl-Terminal Hydrolase 342
Ubiquitin Specific Protease 341 2     Ubiquitin Thiolesterase 342
Deubiquitinating Enzyme 342 3     EC 3.4.19.123
Ubiquitin Thioesterase 342 3     KIAA07293
Ubiquitin-Specific-Processing Protease 342 3     EC 3.1.2.158
KIAA05703 5     

External Ids:    HGNC: 200661   Entrez Gene: 97362   Ensembl: ENSG000001154647   OMIM: 6152955   UniProtKB: Q70CQ23   

Export aliases for USP34 gene to outside databases

Previous GC identifers: GC02M061372 GC02M061389 GC02M061327 GC02M061155


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for USP34 Gene:
USP34 (ubiquitin specific peptidase 34) is a protein-coding gene. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP24.

UniProtKB/Swiss-Prot: UBP34_HUMAN, Q70CQ2
Function: Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a
regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the
beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear
accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes
and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin
precursors as well as that of ubiquitinated proteins

Gene Wiki entry for USP34 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP34 gene promoter:
         TBP   SRF   RREB-1   SRF (504 AA)   MIF-1   AP-4   C/EBPalpha   CHOP-10   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP34 promoter sequence
   Search Chromatin IP Primers for USP34

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p15   Ensembl cytogenetic band:  2p15   HGNC cytogenetic band: 2p16.1-p15

USP34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP34 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M061414:  view genomic region     (about GC identifiers)

Start:
61,414,590 bp from pter      End:
61,697,904 bp from pter
Size:
283,315 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBP34_HUMAN, Q70CQ2 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 34  
Size: 3546 amino acids; 404233 Da
Subunit: Interacts with AXIN1 and AXIN2
Sequence caution: Sequence=AAI07762.1; Type=Frameshift; Positions=3200; Sequence=BAA25496.2; Type=Erroneous
initiation; Sequence=BAG54261.1; Type=Erroneous initiation;
Secondary accessions: A8MWD0 B3KWU9 O60316 O94834 Q3B777 Q6P6C9 Q7L8P6 Q8N3T9 Q8TBW2 Q9UGA1
Alternative splicing: 3 isoforms:  Q70CQ2-1   Q70CQ2-2   Q70CQ2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP34: NX_Q70CQ2

Explore proteomics data for USP34 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys484, Lys1574, Lys1968, Lys2100, Lys2102, Lys2219
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for USP34 (Q70CQ2)
     GSSGPGS  IQQLYMIP 


    See USP34 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055524.3  
    ENSEMBL proteins: 
     ENSP00000398960   ENSP00000381577   ENSP00000398489   ENSP00000410559   ENSP00000388129  
    Reactome Protein details: Q70CQ2

    USP34 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for USP34
    GenScript Custom Purified and Recombinant Proteins Services for USP34
    Novus Biologicals USP34 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP34

     
    Search eBioscience for Proteins for USP34 

     
    antibodies-online proteins for USP34 (2 products) 

     
    Search antibodies-online for peptides for USP34

    USP34 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    Novus Biologicals USP34 Antibodies
    Abcam antibodies for USP34
    Cloud-Clone Corp. Antibodies for USP34
    Search ThermoFisher Antibodies for USP34
    antibodies-online antibodies for USP34 (17 products) 

    USP34 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP34
    Cloud-Clone Corp. CLIAs for USP34
    Search eBioscience for ELISAs for USP34 
    antibodies-online kits for USP34 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    4 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028889 UCH/PAN2
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q70CQ2

    ProtoNet protein and cluster: Q70CQ2

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP34_HUMAN, Q70CQ2
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP34           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP34_HUMAN, Q70CQ2
    Function: Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a
    regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the
    beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear
    accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes
    and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin
    precursors as well as that of ubiquitinated proteins
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IMP--
    GO:0004221ubiquitin thiolesterase activity IDA--
    GO:0004843ubiquitin-specific protease activity IDA14715245
    GO:0005488binding ----
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with USP34           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for USP34:
     Decreased Wnt reporter activit 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for USP34

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP34:
    hsa-mir-21-5p (MIRT030676), hsa-mir-192-5p (MIRT026125), hsa-mir-23a-3p (MIRT050448)

    Block miRNA regulation of human, mouse, rat USP34 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP34 (see all 40):
    hsa-miR-1197 hsa-miR-300 hsa-miR-29a hsa-miR-938 hsa-let-7a-2* hsa-miR-578 hsa-miR-218 hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidUSP34 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP34
    Predesigned siRNA for gene silencing in human, mouse, rat USP34

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP34

    Clone
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    OriGene clones in human, mouse for USP34 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP34 (NM_014709)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP34
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat USP34

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP34


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    cytoskeleton1
    cytosol1
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP34 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis


    Find genes that share SuperPaths with USP34           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP34
        Ubiquitin-Proteasome Dependent Proteolysis

    1 Reactome Pathway for USP34
        TCF dependent signaling in response to WNT


        Pathway & Disease-focused RT2 Profiler PCR Array including USP34: 
              Parkinson's Disease in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for USP34

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP34 (Q70CQ23 ENSP000003815774) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATMQ133153, ENSP000002786164I2D: score=1 STRING: ENSP00000278616
    PRKCHP247233I2D: score=2 
    GRB10Q133223I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    PSMB1ENSP000002621934STRING: ENSP00000262193
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016055Wnt signaling pathway IEA--
    GO:0016579protein deubiquitination IDA14715245
    GO:0071108protein K48-linked deubiquitination IDA--
    GO:0090263positive regulation of canonical Wnt signaling pathway IDA--

    Find genes that share ontologies with USP34           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP34 (UBP34)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP34 gene: 
    NM_014709.3  

    Unigene Cluster for USP34:

    Ubiquitin specific peptidase 34
    Hs.644708  [show with all ESTs]
    Unigene Representative Sequence: NM_014709
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000411912(uc002sbd.3) ENST00000398571(uc002sbe.3) ENST00000436269
    ENST00000492604 ENST00000463046 ENST00000490552 ENST00000498268 ENST00000476716
    ENST00000467128 ENST00000472689 ENST00000472706 ENST00000490527 ENST00000483672
    ENST00000482250 ENST00000487547 ENST00000468703 ENST00000453734(uc002sbf.3)
    ENST00000492882
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP34 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP34 (see all 40):
    hsa-miR-1197 hsa-miR-300 hsa-miR-29a hsa-miR-938 hsa-let-7a-2* hsa-miR-578 hsa-miR-218 hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidUSP34 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for USP34
    Predesigned siRNA for gene silencing in human, mouse, rat USP34
    Clone
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    OriGene clones in human, mouse for USP34 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP34 (NM_014709)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP34
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat USP34
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for USP34
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat USP34
      QuantiTect SYBR Green Assays in human, mouse, rat USP34
      QuantiFast Probe-based Assays in human, mouse, rat USP34

    Additional mRNA sequence: 

    AB018272.1 AJ586138.1 AK001193.1 AK022637.1 AK023171.1 AK125898.1 AL050092.1 AL831918.1 
    BC022783.1 BC062325.1 BC107761.1 

    Selected DOTS entries (see all 32):

    DT.454582  DT.100029825  DT.310893  DT.100655333  DT.40259640  DT.120949935  DT.91761718  DT.211043 
    DT.40123106  DT.120949959  DT.121643738  DT.120950004  DT.120949739  DT.101976383  DT.40215551  DT.100862210 
    DT.100640061  DT.100860192  DT.120949865  DT.120949906  DT.91762447  DT.100804323  DT.120949747  DT.425742 

    Selected AceView cDNA sequences (see all 407):

    AI131502 BM840117 BM786336 BM543337 BU684690 AB018272 BQ434959 AV646092 
    BE349953 AI348308 BM850054 NM_014709 BQ006341 AA769124 AI510818 AK024341 
    BG284411 AI635617 F11278 AJ586138 AA173517 BQ220995 AA992066 AK125898 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for USP34 (see all 21)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^
    SP1:                                                                                                                                                        -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^
    SP1:              -           -                                                                                   -                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 41a · 41b ^ 42 ^ 43 ^ 44a · 44b · 44c ^ 45a · 45b ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^ 51a · 51b ^ 52 ^ 53 ^ 54 ^ 55 ^ 56a · 56b ^ 57 ^ 58a · 58b ^ 59a ·
    SP1:                                                                                                                                                            
    SP2:  -                       -                       -                                                                       -                 -     -     -   
    SP3:                                                                                                        -     -           -                 -     -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 59b ^ 60a · 60b · 60c · 60d ·
    SP1:                              
    SP2:        -                     
    SP3:        -                     
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for USP34

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP34 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGATTGAT
    USP34 Expression
    About this image


    USP34 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
     
     Uterus (Reproductive System)
     
     Testis (Reproductive System)
     
     Ovary (Reproductive System)
    USP34 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP34 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.644708

    UniProtKB/Swiss-Prot: UBP34_HUMAN, Q70CQ2
    Tissue specificity: Expressed in brain at low level

        Pathway & Disease-focused RT2 Profiler PCR Array including USP34: 
              Parkinson's Disease in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP34

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for USP34 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp341 , 5 ubiquitin specific peptidase 341, 5 92.36(n)1
    97.57(a)1
      11 (14.29 cM)5
    178471  NM_001190401.21  NP_001177330.21 
     233069165 
    chicken
    (Gallus gallus)
    Aves USP341 ubiquitin specific peptidase 34 84.69(n)
    93.76(a)
      421193  NM_001199416.1  NP_001186345.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP346
    ubiquitin specific peptidase 34
    93(a)
    1 ↔ 1
    GL343523.1(181595-314812)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.240282 Xenopus laevis transcribed sequence with moderate similarity more 78.5(n)    BX843453.1 
    zebrafish
    (Danio rerio)
    Actinopterygii usp341 ubiquitin specific peptidase 34 71.31(n)
    84.33(a)
      562779  XM_002660563.4  XP_002660609.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG57941 CG5794 52.42(n)
    48.71(a)
      42935  NM_001275993.1  NP_001262922.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T24B8.76
    Protein T24B8.7, isoform a
    16(a)
    1 → many
    II(9042776-9053824) WBGene00011980


    ENSEMBL Gene Tree for USP34 (if available)
    TreeFam Gene Tree for USP34 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP34 gene
    USP242  USP72  USP402  USP182  USP472  USP9Y2  USP9X2  USP482  
    USP412  

    Find genes that share paralogs with USP34           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for USP34
    PGOHUM00000248354


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP34 (see all 6462)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs358073141,2
    C--61361972(+) GCTAA-/T/TTT 
            
    TTTTT
    1 -- int11NA 2
    rs114170171,2
    C--61391009(+) AATAC-/AAAAAA 1 -- int1 trp31Minor allele frequency- A:0.50NA 2
    rs2013564281,2
    C--61415230(+) CTACAC/TCTAAT 1 -- ut311Minor allele frequency- T:0.00EU 1319
    rs1481540081,2
    C--61415274(+) TCCTTA/GTGACG 2 T I mis10--------
    rs1840806171,2
    C--61415311(+) ACACAG/AGGTAT 2 /L syn11Minor allele frequency- A:0.00EU 1321
    rs2013797211,2
    C--61415328(+) TGTCAT/CGTTGC 2 /H /R mis11Minor allele frequency- C:0.00EU 1321
    rs1886148041,2
    C,F--61415378(+) AGAGAT/GAAAGC 2 /L /F mis11Minor allele frequency- G:0.00EU 1323
    rs1921820201,2
    C--61415392(+) CTCAGA/GGTCCT 2 P S mis10--------
    rs2008127951,2
    C--61415397(+) GGTCCC/TGGGAG 2 Q R mis10--------
    rs1438425511,2
    C--61415419(+) GCCATC/GACAGC 2 H D mis10--------

    HapMap Linkage Disequilibrium report for USP34 (61414590 - 61664590 bp, first 250kb of USP34)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for USP34 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666095CNV Deletion23128226
    nsv874228CNV Loss21882294
    dgv4158n71CNV Loss21882294
    nsv528479CNV Loss19592680
    nsv483028CNV Loss15286789
    nsv874213CNV Loss21882294
    nsv874226CNV Loss21882294
    dgv4157n71CNV Loss21882294
    nsv874227CNV Gain21882294
    nsv874212CNV Gain21882294

    Human Gene Mutation Database (HGMD): USP34
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP34
    DNA2.0 Custom Variant and Variant Library Synthesis for USP34

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615295    OMIM disorders: --


    Find genes that share disorders with USP34           About GenesLikeMe

    Genetic Association Database (GAD): USP34
    Human Genome Epidemiology (HuGE) Navigator: USP34 (1 document)

    Export disorders for USP34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP34 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with USP34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling. (PubMed id 21383061)1, 2 Lui T.T.... Angers S. (Mol. Cell. Biol. 2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004)
    6. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    8. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    9. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (DNA Res. 1998)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9736 HGNC: 20066 AceView: USP34 Ensembl:ENSG00000115464 euGenes: HUgn9736
    ECgene: USP34 H-InvDB: USP34

    (According to HUGE)
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    HUGE: KIAA0570 KIAA0729

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP34 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP34 gene:
    Search GeneIP for patents involving USP34

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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