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Aliases for USP34 Gene

Aliases for USP34 Gene

  • Ubiquitin Specific Peptidase 34 2 3
  • KIAA0570 4 6
  • Ubiquitin-Specific-Processing Protease 34 4
  • Ubiquitin Specific Protease 34 2
  • Deubiquitinating Enzyme 34 4
  • Ubiquitin Thioesterase 34 4
  • EC 3.4.19.12 4
  • EC 3.1.2.15 64
  • KIAA0729 4

External Ids for USP34 Gene

Summaries for USP34 Gene

GeneCards Summary for USP34 Gene

USP34 (Ubiquitin Specific Peptidase 34) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include ubiquitin thiolesterase activity and ubiquitin-specific protease activity. An important paralog of this gene is USP41.

UniProtKB/Swiss-Prot for USP34 Gene

  • Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.

Gene Wiki entry for USP34 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP34 Gene

Genomics for USP34 Gene

Genomic Location for USP34 Gene

Start:
61,187,455 bp from pter
End:
61,470,769 bp from pter
Size:
283,315 bases
Orientation:
Minus strand

Genomic View for USP34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP34 Gene

Regulatory Elements for USP34 Gene

Proteins for USP34 Gene

  • Protein details for USP34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70CQ2-UBP34_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 34
    Protein Accession:
    Q70CQ2
    Secondary Accessions:
    • A8MWD0
    • B3KWU9
    • O60316
    • O94834
    • Q3B777
    • Q6P6C9
    • Q7L8P6
    • Q8N3T9
    • Q8TBW2
    • Q9UGA1

    Protein attributes for USP34 Gene

    Size:
    3546 amino acids
    Molecular mass:
    404233 Da
    Quaternary structure:
    • Interacts with AXIN1 and AXIN2.
    SequenceCaution:
    • Sequence=AAI07762.1; Type=Frameshift; Positions=3200; Evidence={ECO:0000305}; Sequence=BAA25496.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG54261.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for USP34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP34 Gene

Proteomics data for USP34 Gene at MOPED

Selected DME Specific Peptides for USP34 Gene

Post-translational modifications for USP34 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys484, Lys1574, Lys1968, Lys2100, Lys2102, and Lys2219

Other Protein References for USP34 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for USP34 Gene

Gene Families for USP34 Gene

HGNC:
  • USP :Ubiquitin-specific peptidases

Protein Domains for USP34 Gene

UniProtKB/Swiss-Prot:

UBP34_HUMAN
Domain:
  • Contains 1 USP domain.:
    • Q70CQ2
Family:
  • Belongs to the peptidase C19 family.:
    • Q70CQ2
genes like me logo Genes that share domains with USP34: view

Function for USP34 Gene

Molecular function for USP34 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function: Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.

Enzyme Numbers (IUBMB) for USP34 Gene

Gene Ontology (GO) - Molecular Function for USP34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IMP 21383061
GO:0004221 ubiquitin thiolesterase activity --
GO:0004843 ubiquitin-specific protease activity IDA 14715245
GO:0005488 binding --
GO:0005515 protein binding IPI 21383061
genes like me logo Genes that share ontologies with USP34: view

Phenotypes for USP34 Gene

GenomeRNAi human phenotypes for USP34:
genes like me logo Genes that share phenotypes with USP34: view

miRNA for USP34 Gene

miRTarBase miRNAs that target USP34

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for USP34 Gene

Localization for USP34 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP34 Gene COMPARTMENTS Subcellular localization image for USP34 gene
Compartment Confidence
plasma membrane 2
cytoskeleton 1
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for USP34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with USP34: view

Pathways for USP34 Gene

genes like me logo Genes that share pathways with USP34: view

Pathways by source for USP34 Gene

1 Qiagen pathway for USP34 Gene

Gene Ontology (GO) - Biological Process for USP34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0016055 Wnt signaling pathway IEA --
GO:0016579 protein deubiquitination IDA 14715245
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0061136 regulation of proteasomal protein catabolic process IBA --
genes like me logo Genes that share ontologies with USP34: view

Transcripts for USP34 Gene

Unigene Clusters for USP34 Gene

Ubiquitin specific peptidase 34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP34 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

ExUns: 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21:

ExUns: 41a · 41b ^ 42 ^ 43 ^ 44a · 44b · 44c ^ 45a · 45b ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^ 51a · 51b ^ 52 ^ 53 ^ 54 ^ 55 ^ 56a · 56b ^ 57 ^ 58a · 58b ^ 59a ·
SP1:
SP2: - - - - - - -
SP3: - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10:
SP11:
SP12:
SP13: -
SP14: -
SP15: - -
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21:

ExUns: 59b ^ 60a · 60b · 60c · 60d ·
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:
SP20: -
SP21:

Relevant External Links for USP34 Gene

GeneLoc Exon Structure for
USP34
ECgene alternative splicing isoforms for
USP34

Expression for USP34 Gene

mRNA expression in normal human tissues for USP34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP34 Gene

SOURCE GeneReport for Unigene cluster for USP34 Gene Hs.644708

mRNA Expression by UniProt/SwissProt for USP34 Gene

Q70CQ2-UBP34_HUMAN
Tissue specificity: Expressed in brain at low level.
genes like me logo Genes that share expressions with USP34: view

Orthologs for USP34 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP34 36
  • 99.78 (n)
  • 99.86 (a)
USP34 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia USP34 36
  • 94.79 (n)
  • 98.55 (a)
USP34 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP34 36
  • 95.16 (n)
  • 98.76 (a)
USP34 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp34 36
  • 92.36 (n)
  • 97.57 (a)
Usp34 16
Usp34 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia USP34 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia USP34 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp34 36
  • 90.78 (n)
  • 96.67 (a)
chicken
(Gallus gallus)
Aves USP34 36
  • 84.69 (n)
  • 93.76 (a)
USP34 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP34 37
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24028 36
tropical clawed frog
(Silurana tropicalis)
Amphibia usp34 36
  • 79.5 (n)
  • 91.27 (a)
zebrafish
(Danio rerio)
Actinopterygii usp34 36
  • 71.31 (n)
  • 84.33 (a)
usp34 37
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003643 36
  • 51.86 (n)
  • 48.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5794 36
  • 52.42 (n)
  • 48.71 (a)
CG5794 37
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T24B8.7 37
  • 16 (a)
OneToMany
Species with no ortholog for USP34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP34 Gene

ENSEMBL:
Gene Tree for USP34 (if available)
TreeFam:
Gene Tree for USP34 (if available)

Paralogs for USP34 Gene

Paralogs for USP34 Gene

Pseudogenes.org Pseudogenes for USP34 Gene

genes like me logo Genes that share paralogs with USP34: view

Variants for USP34 Gene

Sequence variations from dbSNP and Humsavar for USP34 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs751341 -- 61,212,071(+) AAAAT(C/T)AGTAA intron-variant
rs777586 -- 61,201,509(-) AGggc(C/T)ggacg intron-variant
rs777587 -- 61,200,540(-) ATTTT(C/T)ATATG intron-variant
rs777588 -- 61,199,685(-) ACATC(C/T)CAAAT intron-variant
rs777589 -- 61,198,486(-) GGAGT(A/G)CTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP34 Gene

Variant ID Type Subtype PubMed ID
nsv874212 CNV Gain 21882294
nsv528479 CNV Loss 19592680
nsv874213 CNV Loss 21882294
dgv4157n71 CNV Loss 21882294
dgv4158n71 CNV Loss 21882294
nsv7313 OTHER Inversion 18451855
esv2666095 CNV Deletion 23128226
nsv874226 CNV Loss 21882294
nsv874227 CNV Gain 21882294
nsv483028 CNV Loss 15286789
nsv874228 CNV Loss 21882294

Relevant External Links for USP34 Gene

HapMap Linkage Disequilibrium report
USP34
Human Gene Mutation Database (HGMD)
USP34

Disorders for USP34 Gene

Relevant External Links for USP34

Genetic Association Database (GAD)
USP34
Human Genome Epidemiology (HuGE) Navigator
USP34
genes like me logo Genes that share disorders with USP34: view

No data available for UniProtKB/Swiss-Prot for USP34 Gene

Publications for USP34 Gene

  1. The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling. (PMID: 21383061) Lui T.T. … Angers S. (Mol. Cell. Biol. 2011) 3 4
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  5. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3

Products for USP34 Gene

Sources for USP34 Gene

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