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USP33 Gene

protein-coding   GIFtS: 60
GCID: GC01M078161

Ubiquitin Specific Peptidase 33

(Previous name: ubiquitin specific protease 33)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 331 2     PVHL-Interacting Deubiquitinating Enzyme 12
VDU12 3 5     Ubiquitin Carboxyl-Terminal Hydrolase 332
Deubiquitinating Enzyme 332 3     Ubiquitin Thiolesterase 332
Ubiquitin Thioesterase 332 3     EC 3.4.19.123
Ubiquitin-Specific-Processing Protease 332 3     KIAA10973
VHL-Interacting Deubiquitinating Enzyme 12 3     hVDU13
Ubiquitin Specific Protease 331     EC 3.1.2.158

External Ids:    HGNC: 200591   Entrez Gene: 230322   Ensembl: ENSG000000772547   OMIM: 6151465   UniProtKB: Q8TEY73   

Export aliases for USP33 gene to outside databases

Previous GC identifers: GC01M077566 GC01M077584 GC01M077873 GC01M076293


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for USP33 Gene:
This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell
migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by
von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein
isoforms. (provided by RefSeq, Jun 2012)

GeneCards Summary for USP33 Gene:
USP33 (ubiquitin specific peptidase 33) is a protein-coding gene. Diseases associated with USP33 include osteoarthritis, and lymphoblastic leukemia. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP20.

UniProtKB/Swiss-Prot: UBP33_HUMAN, Q8TEY7
Function: Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration
and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating
deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles
duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1,
leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of
the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a
regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins
(ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and
resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination
of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the
translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This
suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby
regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked
polyubiquitin chains

Gene Wiki entry for USP33 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP33 gene promoter:
         GR   AML1a   RelA   NF-E2 p45   NF-kappaB   HNF-1A   HNF-1   ZID   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP33 promoter sequence
   Search Chromatin IP Primers for USP33

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31

USP33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP33 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M078161:  view genomic region     (about GC identifiers)

Start:
78,161,672 bp from pter      End:
78,225,537 bp from pter
Size:
63,866 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UBP33_HUMAN, Q8TEY7 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 33  
Size: 942 amino acids; 106727 Da
Subunit: Interacts with VHL, leading to its ubiquitination and subsequent degradation. Interacts with ARRB1,
ARRB2, ADRB2, DIO2 and ROBO1. Interacts with SELENBP1; in a selenium-dependent manner. Interacts with CCP110
Developmental stage: Increased expression in S and early G2 phases and lower levels in late G2 and M phases
Sequence caution: Sequence=BAA83049.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for USP33:
2UZG (3D)    
Secondary accessions: Q8TEY6 Q96AV6 Q9H9F0 Q9UPQ5
Alternative splicing: 3 isoforms:  Q8TEY7-1   Q8TEY7-2   Q8TEY7-3   

Explore the universe of human proteins at neXtProt for USP33: NX_Q8TEY7

Explore proteomics data for USP33 at MOPED

Post-translational modifications: 

  • Ubiquitinated via a VHL-dependent pathway for proteasomal degradation1
  • Ubiquitination2 at Lys50, Lys258, Lys882
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for USP33 (Q8TEY7)
     YSRYGGGP  QQDAQEFL 


    See USP33 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_055832.3  NP_963918.1  NP_963920.1  

    ENSEMBL proteins: 
     ENSP00000359830   ENSP00000432392   ENSP00000359829   ENSP00000359828   ENSP00000432667  
     ENSP00000434441   ENSP00000433283   ENSP00000436441   ENSP00000350009  

    USP33 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for USP33
    OriGene Protein Over-expression Lysate for USP33
    OriGene MassSpec for USP33
    OriGene Custom Protein Services for USP33
    GenScript Custom Purified and Recombinant Proteins Services for USP33
    Novus Biologicals USP33 Proteins
    Novus Biologicals USP33 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP33

    USP33 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of USP33
    Browse R&D Systems for Antibodies
    OriGene Antibodies for USP33
    OriGene Custom Antibody Services for USP33
    Novus Biologicals USP33 Antibodies
    Abcam antibodies for USP33
    Cloud-Clone Corp. Antibodies for USP33
    ThermoFisher Antibodies for USP33
    LSBio Antibodies in human, mouse, rat for USP33

    USP33 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP33
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP33
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP33
    Cloud-Clone Corp. CLIAs for USP33


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    Selected InterPro protein domains (see all 6):
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR013083 Znf_RING/FYVE/PHD
     IPR028889 UCH/PAN2
     IPR006615 Pept_C19_DUSP

    Graphical View of Domain Structure for InterPro Entry Q8TEY7

    ProtoNet protein and cluster: Q8TEY7

    3 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB001607 Zn-finger in ubiquitin thiolesterase
    IPB006615 Ubiquitin-specific protease DUSP


    UniProtKB/Swiss-Prot: UBP33_HUMAN, Q8TEY7
    Domain: The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the
    conserved Arg in position 86 is replaced by a Glu residue
    Similarity: Belongs to the peptidase C19 family. USP20/USP33 subfamily
    Similarity: Contains 2 DUSP domains
    Similarity: Contains 1 UBP-type zinc finger
    Similarity: Contains 1 USP domain


    USP33 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP33_HUMAN, Q8TEY7
    Function: Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration
    and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating
    deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles
    duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1,
    leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of
    the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a
    regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins
    (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and
    resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination
    of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the
    translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This
    suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby
    regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked
    polyubiquitin chains
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IPI19424180
    GO:0004197cysteine-type endopeptidase activity IMP19363159
    GO:0004221ubiquitin thiolesterase activity IDA19363159
    GO:0004843ubiquitin-specific protease activity TAS11739384
    GO:0005515protein binding IPI11739384
         
    USP33 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for USP33:
     Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Usp33):
     homeostasis/metabolism 

    USP33 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP33
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP33

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP33
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP33

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP33:
    hsa-mir-1 (MIRT023537), hsa-mir-148b-3p (MIRT019307), hsa-mir-877-5p (MIRT037270)

    Block miRNA regulation of human, mouse, rat USP33 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP33 (see all 43):
    hsa-miR-4307 hsa-miR-4272 hsa-miR-301a hsa-miR-371-5p hsa-miR-890 hsa-miR-642b hsa-miR-130b hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidUSP33 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP33
    Predesigned siRNA for gene silencing in human, mouse, rat USP33

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP33

    Clone
    Products:
         
    OriGene clones in human, mouse for USP33 (see all 19)
    OriGene ORF clones in mouse, rat for USP33
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): USP33 (NM_201624)
    Sino Biological Human cDNA Clone for USP33
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP33

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for USP33
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP33 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP33


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBP33_HUMAN, Q8TEY7: Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center,
    centrosome. Note=Associates with centrosomes predominantly in S and G2 phases but less in G1 phase
    UBP33_HUMAN, Q8TEY7: Isoform 3: Golgi apparatus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus5
    cytosol2
    nucleus2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS11739384
    GO:0005794Golgi apparatus IEA--
    GO:0005813centrosome IDA--
    GO:0030891VCB complex TAS11739384
    GO:0044297cell body IEA--

    USP33 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP33 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP33
        Ubiquitin-Proteasome Dependent Proteolysis



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP33
    Interactions:

        GeneGlobe Interaction Network for USP33

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP33 (Q8TEY71, 2, 3 ENSP000003500094) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRB2P075502, 3, ENSP000003053724MINT-7291631 MINT-7291604 I2D: score=1 STRING: ENSP00000305372
    SELENBP1Q132281, 3, ENSP000003578614EBI-719307,EBI-711619 I2D: score=2 STRING: ENSP00000357861
    VHLP403373, ENSP000002564744I2D: score=4 STRING: ENSP00000256474
    IFIT5Q133253, ENSP000003608604I2D: score=2 STRING: ENSP00000360860
    KRR1Q136013, ENSP000002292144I2D: score=2 STRING: ENSP00000229214
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process TAS11739384
    GO:0006897endocytosis IEA--
    GO:0007411axon guidance ISS--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway IMP19363159
    GO:0016477cell migration ISS--

    USP33 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP33 (UBP33)

    1 HMDB Compound for USP33    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for USP33 gene (3 alternative transcripts): 
    NM_015017.4  NM_201624.2  NM_201626.2  

    Unigene Cluster for USP33:

    Ubiquitin specific peptidase 33
    Hs.480597  [show with all ESTs]
    Unigene Representative Sequence: NM_015017
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370794(uc001dhs.3 uc001dhu.3) ENST00000481579 ENST00000370793(uc001dht.3)
    ENST00000533928 ENST00000477949 ENST00000370792(uc001dhv.3 uc001dhw.3)
    ENST00000527390 ENST00000472462 ENST00000498328 ENST00000461986 ENST00000531637
    ENST00000462192 ENST00000524536 ENST00000525113 ENST00000528150 ENST00000530709
    ENST00000524778 ENST00000357428
    miRNA
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    Block miRNA regulation of human, mouse, rat USP33 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP33 (see all 43):
    hsa-miR-4307 hsa-miR-4272 hsa-miR-301a hsa-miR-371-5p hsa-miR-890 hsa-miR-642b hsa-miR-130b hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidUSP33 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for USP33
    Predesigned siRNA for gene silencing in human, mouse, rat USP33
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): USP33 (NM_201624)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP33
    Primer
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    OriGene qPCR primer pairs and template standards for USP33
    OriGene qSTAR qPCR primer pairs in human, mouse for USP33
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP33
      QuantiTect SYBR Green Assays in human, mouse, rat USP33
      QuantiFast Probe-based Assays in human, mouse, rat USP33

    Additional mRNA sequence: 

    AB029020.1 AF383172.1 AF383173.1 AK022864.1 AK023664.1 AK094056.1 AK225499.1 AK308402.1 
    AL050140.1 BC016663.1 

    23 DOTS entries:

    DT.100668639  DT.86853063  DT.100797895  DT.100797892  DT.97859382  DT.95088481  DT.91749028  DT.100803718 
    DT.97859380  DT.75106382  DT.102832825  DT.40126884  DT.91970363  DT.97810520  DT.97859383  DT.100797894 
    DT.210202  DT.443634  DT.91666009  DT.91749024  DT.95088480  DT.95088510  DT.97784216 

    Selected AceView cDNA sequences (see all 266):

    BQ950373 AW058287 BF111438 CA311769 AA150873 AI262057 CB990794 BU157145 
    BC016663 AW516171 AI672000 BI752000 CB135072 BM985175 AK023664 AI634201 
    BE504284 AA129590 H89599 AI983638 BQ773948 BM684718 AI805499 AL050140 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for USP33 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:              -     -                                                                                                                                       
    SP2:              -     -     -                                                                                                                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:              -     -     -                                                                                                                                 

    ExUns: 20
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for USP33

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP33 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCTTTGT
    USP33 Expression
    About this image

    USP33 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP33 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.480597

    UniProtKB/Swiss-Prot: UBP33_HUMAN, Q8TEY7
    Tissue specificity: Widely expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP33 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp331 , 5 ubiquitin specific peptidase 331, 5 87.13(n)1
    92.63(a)1
      3 (77.15 cM)5
    1708221  NM_133247.31  NP_573510.21 
     1523464785 
    chicken
    (Gallus gallus)
    Aves USP331 ubiquitin specific peptidase 33 78.99(n)
    82.73(a)
      424553  XM_004936670.1  XP_004936727.1 
    lizard
    (Anolis carolinensis)
    Reptilia USP336
    ubiquitin specific peptidase 33
    79(a)
    1 ↔ 1
    GL343194.1(4641618-4684112)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL883737.22   -- 80.73(n)    AL883737.2 
    zebrafish
    (Danio rerio)
    Actinopterygii usp331 ubiquitin specific peptidase 33 67.23(n)
    71.85(a)
      406508  NM_213227.1  NP_998392.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG84946
    --
    31(a)
    1 → many
    2R(10127442-10131167)
    worm
    (Caenorhabditis elegans)
    Secernentea usp-336
    Protein USP-33 (usp-33) mRNA, complete cds
    21(a)
    1 → many
    X(15591368-15595354) WBGene00010702
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP106
    Ubiquitin-specific protease that deubiquitinates u...
    16(a)
    1 → many
    XIV(289498-291876) YNL186W


    ENSEMBL Gene Tree for USP33 (if available)
    TreeFam Gene Tree for USP33 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP33 gene
    USP202  
    13 SIMAP similar genes for USP33 using alignment to 6 protein entries:     UBP33_HUMAN (see all proteins):
    DKFZp586N041    LSFR3A    USP20    USP2    USP3    USP15
    USP48    USP11    USP17L13    USP36    USP44    DKFZp434K1822
    USP30

    USP33 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP33 (see all 1148)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1823966621,2
    --78161194(+) CAAAAC/TAGCAA 2 -- ds50010--------
    rs1869757381,2
    --78161230(+) ATAAAA/TATTAG 2 -- ds50010--------
    rs1439263151,2
    C--78161388(+) ATGGTA/GAAACC 2 -- ds50010--------
    rs1930068601,2
    --78161516(+) GAGCCA/CAGACT 2 -- ds50010--------
    rs171009341,2
    C,F,H--78161630(+) TTGCAC/ACTTTT 2 -- ds50018Minor allele frequency- A:0.04NA NS EA WA 680
    rs1473957931,2
    C--78161794(+) ATCCAA/GTATGT 2 -- ut310--------
    rs1380405631,2
    --78161933(+) ATCAAC/TAATCG 2 -- ut310--------
    rs1833383791,2
    --78161938(+) CAATCA/GTAGTG 2 -- ut310--------
    rs413066371,2
    F--78161998(+) CTCTAA/GGTTTT 2 -- ut311Minor allele frequency- G:0.01NA 120
    rs570752651,2
    C,F--78162073(+) CGGCAA/GTAAGT 2 -- ut311Minor allele frequency- G:0.41EA 120

    HapMap Linkage Disequilibrium report for USP33 (78161672 - 78225537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for USP33:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508326CNV Loss20534489
    nsv830303CNV Loss17160897
    nsv870709CNV Loss21882294
    nsv470719CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615146    OMIM disorders: --

    5 diseases for USP33:    
    About MalaCards
    osteoarthritis    lymphoblastic leukemia    thyroiditis    leukemia
    breast cancer


    USP33 for disorders           About GeneDecksing

    Genetic Association Database (GAD): USP33
    Human Genome Epidemiology (HuGE) Navigator: USP33 (1 document)

    Export disorders for USP33 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP33 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with USP33)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. (PubMed id 11739384)1, 2, 9 Li Z.... Wu G. (J. Biol. Chem. 2002)
    2. Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner. (PubMed id 19118533)1, 2, 9 Jeong J.Y.... Sytkowski A.J. (Biochem. Biophys. Res. Commun. 2009)
    3. USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. (PubMed id 23486064)1, 2 Li J.... Dynlacht B.D. (Nature 2013)
    4. Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility. (PubMed id 20724312)1, 4 Meulenbelt I....Slagboom P.E. (Ann. Rheum. Dis. 2011)
    5. Isoform-specific localization of the deubiquitinase USP33 to the Golgi apparatus. (PubMed id 21801292)1, 2 Thorne C.... Clague M.J. (Traffic 2011)
    6. The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. (PubMed id 19424180)1, 2 Berthouze M.... Shenoy S.K. (EMBO J. 2009)
    7. Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. (PubMed id 19363159)1, 2 Shenoy S.K.... Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    8. The solution structure of the ZnF UBP domain of USP33/VDU1. (PubMed id 17766394)1, 2 Allen M.D. and Bycroft M. (Protein Sci. 2007)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23032 HGNC: 20059 AceView: USP33 Ensembl:ENSG00000077254 euGenes: HUgn23032
    ECgene: USP33 H-InvDB: USP33

    (According to HUGE)
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    HUGE: KIAA1097

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP33 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP33 gene:
    Search GeneIP for patents involving USP33

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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