USP33 Gene
protein-coding GIFtS: 56
GCID: GC01M078161
|
|
ubiquitin specific peptidase 33(Previous name: ubiquitin specific protease 33 )
| |
Aliases
for USP33 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 331 2 | | Ubiquitin Specific Protease 331 | | VDU11 2 3 | | PVHL-Interacting Deubiquitinating Enzyme 12 | | KIAA10971 3 | | Ubiquitin Carboxyl-Terminal Hydrolase 332 | | Deubiquitinating Enzyme 332 3 | | Ubiquitin Thiolesterase 332 | | Ubiquitin Thioesterase 332 3 | | EC 3.4.19.123 | | Ubiquitin-Specific-Processing Protease 332 3 | | HVDU11 | | VHL-Interacting Deubiquitinating Enzyme 12 3 | | EC 3.1.2.158 |
Export aliases for USP33 gene to outside databasesPrevious GC identifers: GC01M077566 GC01M077584 GC01M077873 GC01M076293 |
Summaries
for USP33 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for USP33:
This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migrationand beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by vonHippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms.(provided by RefSeq, Jun 2012)
UniProtKB/Swiss-Prot: UBP33_HUMAN, Q8TEY7Function: Deubiquitinating enzyme involved in various processes such as cellular migration and beta-2 adrenergicreceptor/ADRB2 recycling. Involved in cell migration via its interaction with intracellular domain of ROBO1, leadingto regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tubein a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-proteincoupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agoniststimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal traffickingof ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestinsdeubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 andbeta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
Gene Wiki entry for USP33
|
Genomic Views
for USP33 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP33 gene promoter:
GR AML1a RelA NF-E2 p45 NF-kappaB HNF-1A HNF-1 ZID GR-alpha NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP33
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP33 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p31.1 Ensembl cytogenetic band: 1p31.1 HGNC cytogenetic band: 1p31USP33 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M078161: view genomic region
(about GC identifiers)
Start:
|
78,161,672 bp from pter |
End:
|
78,225,537 bp from pter |
Size:
|
63,866 bases |
Orientation:
|
minus strand |
|
Proteins
for USP33 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP33_HUMAN, Q8TEY7 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 33 Size: 942 amino acids; 106727 Da
Subunit: Interacts with VHL, leading to its ubiquitination and subsequent degradation. Interacts with ARRB1, ARRB2,ADRB2, DIO2 and ROBO1. Interacts with SELENBP1; in a selenium-dependent manner
Subcellular location: Cytoplasm, perinuclear region. Note=According to PubMed:12865408, it localizes in the endoplasmicreticulum; however the relevance of such result is unclear
Sequence caution: Sequence=BAA83049.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for USP33:2UZG (3D)
Secondary accessions: Q8TEY6 Q96AV6 Q9H9F0 Q9UPQ5Alternative splicing: 3 isoforms: Q8TEY7-1 Q8TEY7-2 Q8TEY7-3 Explore the universe of human proteins at neXtProt for USP33: NX_Q8TEY7
Post-translational modifications:
Ubiquitinated via a VHL-dependent pathway for proteasomal degradation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TEY7
2 DME Specific Peptides for USP33 (Q8TEY7)
USP33 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_055832.3 NP_963918.1 NP_963920.1
ENSEMBL proteins: ENSP00000359830 ENSP00000432392 ENSP00000359829 ENSP00000359828 ENSP00000432667 ENSP00000434441 ENSP00000433283 ENSP00000436441 ENSP00000350009
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
USP33 for ontologies About GeneDecksing
USP33 Antibody Products:
Assay Products for USP33: |
Protein
Domains /
Families
for USP33 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP33 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TEY7ProtoNet protein and cluster: Q8TEY7 3 Blocks protein families: IPB001394 Ubiquitin thiolesterase IPB001607 Zn-finger in ubiquitin thiolesterase IPB006615 Ubiquitin-specific protease DUSP
UniProtKB/Swiss-Prot: UBP33_HUMAN, Q8TEY7Domain: The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conservedArg in position 86 is replaced by a Glu residueSimilarity: Belongs to the peptidase C19 family. USP20/USP33 subfamilySimilarity: Contains 2 DUSP domainsSimilarity: Contains 1 UBP-type zinc finger |
Function
for USP33 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBP33_HUMAN, Q8TEY7Function: Deubiquitinating enzyme involved in various processes such as cellular migration and beta-2 adrenergicreceptor/ADRB2 recycling. Involved in cell migration via its interaction with intracellular domain of ROBO1, leadingto regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tubein a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-proteincoupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agoniststimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal traffickingof ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestinsdeubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 andbeta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both'Lys-48'- and 'Lys-63'-linked polyubiquitin chainsCatalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP33 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP33 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): USP33 (NM_201624) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP33 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP33 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP33 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
USP33 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for USP33:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Usp33):
USP33 for phenotypes About GeneDecksing
|
Pathways & Interactions
for USP33 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitin-Proteasome Dependent Proteolysis | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP33
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for USP33
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
5/31 Interacting proteins for USP33 (Q8TEY71, 2, 3 ENSP000003500094) via UniProtKB, MINT, STRING, and/or I2D (see all 31)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
USP33 for ontologies About GeneDecksing
|
Drugs & Compounds
for USP33 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USP33
1 HMDB Compound for USP33 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Water | Dihydrogen oxide (see all 2) | 7732-18-5 | -- |
Search CenterWatch for drugs/clinical trials and news about USP33 / UBP33
|
Transcripts
for USP33 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP33 gene (3 alternative transcripts): NM_015017.4 NM_201624.2 NM_201626.2 Unigene Cluster for USP33: Ubiquitin specific peptidase 33 Hs.480597 [show with all ESTs]Unigene Representative Sequence: NM_01501718 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370794(uc001dhs.3 uc001dhu.3) ENST00000481579 ENST00000370793(uc001dht.3)
ENST00000533928 ENST00000477949 ENST00000370792(uc001dhv.3 uc001dhw.3)
ENST00000527390 ENST00000472462 ENST00000498328 ENST00000461986 ENST00000531637
ENST00000462192 ENST00000524536 ENST00000525113 ENST00000528150 ENST00000530709
ENST00000524778 ENST00000357428
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP33 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP33 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): USP33 (NM_201624) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP33 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP33 |
Additional cDNA sequence: AB029020.1 AF383172.1 AF383173.1 AK022864.1 AK023664.1 AK094056.1 AK225499.1 AK308402.1 AL050140.1 BC016663.1 23 DOTS entries: DT.100668639 DT.86853063 DT.100797895 DT.100797892 DT.97859382 DT.95088481 DT.91749028 DT.100803718 DT.97859380 DT.75106382 DT.102832825 DT.40126884 DT.91970363 DT.97810520 DT.97859383 DT.100797894 DT.210202 DT.443634 DT.91666009 DT.91749024 DT.95088480 DT.95088510 DT.97784216 24/266 AceView cDNA sequences (see all 266): AU132896 CA428760 AA251528 AI638360 CA390419 CR619326 AF383173 AB029020 BE891829 AL705363 BP350325 AI572232 AW451188 CB132434 BM460265 AW594064 AW474844 NM_201624 AI262057 CA412581 AI422805 BU632737 AW516115 H27736
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for USP33 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20 |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for USP33
|
Expression
for USP33 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP33 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGCTTTGT
About this image
See USP33 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP33
SOURCE GeneReport for Unigene cluster: Hs.480597
UniProtKB/Swiss-Prot: UBP33_HUMAN, Q8TEY7Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for USP33
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP33
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP33 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP33 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP33 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP33 |
Orthologs
for USP33 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for USP33 gene from 6/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
USP331 |
ubiquitin specific peptidase 33 |
79(n)
82.71(a) |
|
424553 XM_422389.2 XP_422389.2 |
lizard
(Anolis carolinensis) |
Reptilia |
USP336 |
-- |
79(a) |
1 ↔ 1 |
GL343194.1(4641880-4677312) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
AL883737.22 |
-- |
80.73(n) |
|
AL883737.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
usp331 |
ubiquitin specific peptidase 33 |
67.23(n)
71.85(a) |
|
406508 NM_213227.1 NP_998392.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG84946 |
-- |
30(a) |
1 → many |
2R(10127442-10131167) |
worm
(Caenorhabditis elegans) |
Secernentea |
T22F3.26 |
Protein T22F3.2, isoform b |
17(a) |
possible ortholog |
V(3586637-3589004) |
ENSEMBL Gene Tree for USP33 (if available)
TreeFam Gene Tree for USP33 (if available) |
Paralogs
for USP33 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP33 gene
- USP32 USP442 USP162 USP452 USP512 USP222 USP492 USP202
12 SIMAP similar genes for USP33 using alignment to 6 protein entries: UBP33_HUMAN (see all proteins):DKFZp586N041 LSFR3A USP20 USP2 USP3 USP15
USP48 USP11 USP17L13 USP36 USP44 DKFZp434K1822
USP33 for paralogs About GeneDecksing
|
Genomic Variants
for USP33 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP33 (78161672 - 78225537 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for USP33: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP33 |
|
Disorders
/ Diseases
for USP33 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP33 for disorders About GeneDecksing
7  diseases for USP33: About MalaCardsacute lymphoblastic leukemia lymphoblastic leukemia osteoarthritis leukemia
breast cancer thyroiditis malaria
Human Genome Epidemiology (HuGE) Navigator: USP33 (1 document)
Export disorders for USP33 gene to outside databases
|
Publications
for USP33 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USP33 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with USP33) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. (PubMed id 11739384)1, 2, 9 Li Z.... Wu G. (2002)
- Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner. (PubMed id 19118533)1, 2, 9 Jeong J.Y.... Sytkowski A.J. (2009)
- Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. (PubMed id 19363159)1, 2 Shenoy S.K.... Lefkowitz R.J. (2009)
- The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. (PubMed id 19424180)1, 2 Berthouze M.... Shenoy S.K. (2009)
- The solution structure of the ZnF UBP domain of USP33/VDU1. (PubMed id 17766394)1, 2 Allen M.D. and Bycroft M. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Deubiquitination of type 2 iodothyronine deiodinase by von Hippel- Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. (PubMed id 12865408)1, 2 Curcio-Morelli C.... Bianco A.C. (2003)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
|
External Searches for USP33 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing USP33 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing USP33 gene
(According to HUGE)
About This Section
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Specialized Databases showing USP33 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for USP33 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for USP33 gene:
Search GeneIP for patents involving USP33
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for USP33 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP33 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP33 | | | OriGene Protein Over-expression Lysate for USP33 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for USP33 | | OriGene 3'-UTR Clone for USP33 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP33 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP33 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for USP33 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for USP33 | | OriGene Custom Protein Services for USP33 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP33 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP33 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP33 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP33 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP33 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP33 |
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| | | | Search Tocris compounds for USP33 |
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 | | | USP33 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP33 |
|  |  |  | | | | ThermoFisher Antibodies for USP33 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP33 |
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