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Aliases for USP33 Gene

Aliases for USP33 Gene

  • Ubiquitin Specific Peptidase 33 2 3 5
  • Ubiquitin-Specific-Processing Protease 33 3 4
  • VHL-Interacting Deubiquitinating Enzyme 1 3 4
  • Deubiquitinating Enzyme 33 3 4
  • Ubiquitin Thioesterase 33 3 4
  • VDU1 3 4
  • PVHL-Interacting Deubiquitinating Enzyme 1 3
  • Ubiquitin Specific Protease 33 2
  • Ubiquitin Thiolesterase 33 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 63
  • KIAA1097 4
  • HVDU1 4

External Ids for USP33 Gene

Previous GeneCards Identifiers for USP33 Gene

  • GC01M077566
  • GC01M077584
  • GC01M077873
  • GC01M078161
  • GC01M076293

Summaries for USP33 Gene

Entrez Gene Summary for USP33 Gene

  • This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

GeneCards Summary for USP33 Gene

USP33 (Ubiquitin Specific Peptidase 33) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP50.

UniProtKB/Swiss-Prot for USP33 Gene

  • Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for USP33 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP33 Gene

Genomics for USP33 Gene

Regulatory Elements for USP33 Gene

Promoters for USP33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around USP33 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP33 Gene

Chromosome:
1
Start:
77,695,987 bp from pter
End:
77,759,879 bp from pter
Size:
63,893 bases
Orientation:
Minus strand

Genomic View for USP33 Gene

Genes around USP33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP33 Gene

Proteins for USP33 Gene

  • Protein details for USP33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEY7-UBP33_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 33
    Protein Accession:
    Q8TEY7
    Secondary Accessions:
    • Q8TEY6
    • Q96AV6
    • Q9H9F0
    • Q9UPQ5

    Protein attributes for USP33 Gene

    Size:
    942 amino acids
    Molecular mass:
    106727 Da
    Quaternary structure:
    • Interacts with VHL, leading to its ubiquitination and subsequent degradation. Interacts with ARRB1, ARRB2, ADRB2, DIO2 and ROBO1. Interacts with SELENBP1; in a selenium-dependent manner. Interacts with CCP110.
    SequenceCaution:
    • Sequence=BAA83049.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for USP33 Gene

    Alternative splice isoforms for USP33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP33 Gene

Proteomics data for USP33 Gene at MOPED

Selected DME Specific Peptides for USP33 Gene

Post-translational modifications for USP33 Gene

  • Ubiquitinated via a VHL-dependent pathway for proteasomal degradation.
  • Ubiquitination at Lys 50, Lys 258, and Lys 882
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for USP33 Gene

Gene Families for USP33 Gene

Suggested Antigen Peptide Sequences for USP33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TEY7

UniProtKB/Swiss-Prot:

UBP33_HUMAN :
  • The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 86 is replaced by a Glu residue.
  • Belongs to the peptidase C19 family. USP20/USP33 subfamily.
  • Contains 1 UBP-type zinc finger.
Domain:
  • The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 86 is replaced by a Glu residue.
  • Contains 2 DUSP domains.
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family. USP20/USP33 subfamily.
Similarity:
  • Contains 1 UBP-type zinc finger.
genes like me logo Genes that share domains with USP33: view

Function for USP33 Gene

Molecular function for USP33 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both Lys-48- and Lys-63-linked polyubiquitin chains.

Enzyme Numbers (IUBMB) for USP33 Gene

Gene Ontology (GO) - Molecular Function for USP33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 19424180
GO:0004843 thiol-dependent ubiquitin-specific protease activity IEA,TAS 11739384
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP33: view
genes like me logo Genes that share phenotypes with USP33: view

Animal Models for USP33 Gene

MGI Knock Outs for USP33:

Animal Model Products

  • Taconic Biosciences Mouse Models for USP33

miRNA for USP33 Gene

miRTarBase miRNAs that target USP33

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for USP33 Gene

Localization for USP33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP33 Gene

Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrosomes predominantly in S and G2 phases but less in G1 phase (PubMed:23486064). {ECO:0000269 PubMed:23486064}.
Isoform 3: Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP33 Gene COMPARTMENTS Subcellular localization image for USP33 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
nucleus 5
cytosol 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for USP33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 23486064
GO:0044297 cell body IEA --
GO:0048471 perinuclear region of cytoplasm IDA 24056301
genes like me logo Genes that share ontologies with USP33: view

Pathways & Interactions for USP33 Gene

genes like me logo Genes that share pathways with USP33: view

Pathways by source for USP33 Gene

1 Qiagen pathway for USP33 Gene

Gene Ontology (GO) - Biological Process for USP33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA,TAS 11739384
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IMP 19363159
GO:0016579 protein deubiquitination IEA,IMP 24056301
GO:0032091 negative regulation of protein binding IMP 24056301
GO:0050821 protein stabilization IMP 23486064
genes like me logo Genes that share ontologies with USP33: view

No data available for SIGNOR curated interactions for USP33 Gene

Drugs & Compounds for USP33 Gene

(1) Additional Compounds for USP33 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with USP33: view

Transcripts for USP33 Gene

Unigene Clusters for USP33 Gene

Ubiquitin specific peptidase 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP33 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - -
SP2: - - -
SP3:
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:

ExUns: 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for USP33 Gene

GeneLoc Exon Structure for
USP33
ECgene alternative splicing isoforms for
USP33

Expression for USP33 Gene

mRNA expression in normal human tissues for USP33 Gene

Protein differential expression in normal tissues from HIPED for USP33 Gene

This gene is overexpressed in Placenta (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP33 Gene



SOURCE GeneReport for Unigene cluster for USP33 Gene Hs.480597

mRNA Expression by UniProt/SwissProt for USP33 Gene

Q8TEY7-UBP33_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with USP33: view

Protein tissue co-expression partners for USP33 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for USP33 Gene

Orthologs for USP33 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP33 35
  • 99.65 (n)
  • 99.68 (a)
USP33 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia USP33 36
  • 96 (a)
OneToOne
USP33 35
  • 94.4 (n)
  • 96.71 (a)
dog
(Canis familiaris)
Mammalia USP33 35
  • 94.11 (n)
  • 97.15 (a)
USP33 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp33 16
Usp33 36
  • 92 (a)
OneToOne
Usp33 35
  • 87.13 (n)
  • 92.63 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia USP33 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Usp33 35
  • 88.73 (n)
  • 93.19 (a)
chicken
(Gallus gallus)
Aves USP33 35
  • 78.99 (n)
  • 82.73 (a)
USP33 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP33 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp33 35
  • 73.59 (n)
  • 77.1 (a)
zebrafish
(Danio rerio)
Actinopterygii usp33 36
  • 70 (a)
OneToOne
usp33 35
  • 67.23 (n)
  • 71.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8494 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea usp-33 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP10 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for USP33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP33 Gene

ENSEMBL:
Gene Tree for USP33 (if available)
TreeFam:
Gene Tree for USP33 (if available)

Paralogs for USP33 Gene

Paralogs for USP33 Gene

genes like me logo Genes that share paralogs with USP33: view

Variants for USP33 Gene

Sequence variations from dbSNP and Humsavar for USP33 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs717333 -- 77,753,505(-) TTATG(A/C)GAACA intron-variant
rs1058816 -- 77,711,778(+) AAAAA(A/C/G/T)AAGAA reference, missense
rs1968027 -- 77,726,042(-) AATCC(A/G)GGATG intron-variant
rs2274123 -- 77,740,997(+) AATTT(A/C)TAACA intron-variant
rs2274124 -- 77,741,218(+) AAGAT(C/G)TTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP33 Gene

Variant ID Type Subtype PubMed ID
nsv470719 CNV Gain 18288195
nsv870709 CNV Loss 21882294
nsv830303 CNV Loss 17160897
nsv508326 CNV Loss 20534489

Variation tolerance for USP33 Gene

Residual Variation Intolerance Score: 10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP33 Gene

HapMap Linkage Disequilibrium report
USP33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP33 Gene

Disorders for USP33 Gene

Relevant External Links for USP33

Genetic Association Database (GAD)
USP33
Human Genome Epidemiology (HuGE) Navigator
USP33
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP33

No disorders were found for USP33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP33 Gene

Publications for USP33 Gene

  1. Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. (PMID: 11739384) Li Z. … Wu G. (J. Biol. Chem. 2002) 3 4 23 67
  2. Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner. (PMID: 19118533) Jeong J.Y. … Sytkowski A.J. (Biochem. Biophys. Res. Commun. 2009) 3 23
  3. Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration. (PMID: 19706539) Yuasa-Kawada J. … Wu J.Y. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  4. Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity. (PMID: 17452445) Sagar G.D. … Bianco A.C. (Mol. Cell. Biol. 2007) 3 23
  5. A leukemia-enriched cDNA microarray platform identifies new transcripts with relevance to the biology of pediatric acute lymphoblastic leukemia. (PMID: 15996926) De PittA C. … Lanfranchi G. (Haematologica 2005) 3 23

Products for USP33 Gene

Sources for USP33 Gene

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