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Aliases for USP32 Gene

Aliases for USP32 Gene

  • Ubiquitin Specific Peptidase 32 2 3
  • Ubiquitin-Specific-Processing Protease 32 3 4
  • Renal Carcinoma Antigen NY-REN-60 3 4
  • Ubiquitin Specific Protease 32 2 3
  • Deubiquitinating Enzyme 32 3 4
  • Ubiquitin Thioesterase 32 3 4
  • USP10 3 4
  • Ubiquitin Thiolesterase 32 3
  • EC 3.4.19.12 4
  • EC 3.1.2.15 63
  • NY-REN-60 3

External Ids for USP32 Gene

Previous GeneCards Identifiers for USP32 Gene

  • GC17M058596
  • GC17M058730
  • GC17M058729
  • GC17M055609
  • GC17M058254
  • GC17M053625

Summaries for USP32 Gene

GeneCards Summary for USP32 Gene

USP32 (Ubiquitin Specific Peptidase 32) is a Protein Coding gene. Among its related pathways are DNA Damage and DNA Double-Strand Break Repair. GO annotations related to this gene include calcium ion binding and ubiquitin-specific protease activity. An important paralog of this gene is USP4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP32 Gene

Genomics for USP32 Gene

Regulatory Elements for USP32 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for USP32 Gene

Chromosome:
17
Start:
60,177,231 bp from pter
End:
60,422,470 bp from pter
Size:
245,240 bases
Orientation:
Minus strand

Genomic View for USP32 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for USP32 Gene

Proteins for USP32 Gene

  • Protein details for USP32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFA0-UBP32_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 32
    Protein Accession:
    Q8NFA0
    Secondary Accessions:
    • Q7Z5T3
    • Q9BX85
    • Q9Y591

    Protein attributes for USP32 Gene

    Size:
    1604 amino acids
    Molecular mass:
    181656 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for USP32 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP32 Gene

Proteomics data for USP32 Gene at MOPED

Selected DME Specific Peptides for USP32 Gene

Post-translational modifications for USP32 Gene

  • Ubiquitination at Lys 951
  • Modification sites at PhosphoSitePlus

Domains & Families for USP32 Gene

Suggested Antigen Peptide Sequences for USP32 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NFA0

UniProtKB/Swiss-Prot:

UBP32_HUMAN :
  • Contains 1 DUSP domain.
  • Belongs to the peptidase C19 family.
Domain:
  • Contains 1 DUSP domain.
  • Contains 3 EF-hand domains.
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP32: view

Function for USP32 Gene

Molecular function for USP32 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme Numbers (IUBMB) for USP32 Gene

Gene Ontology (GO) - Molecular Function for USP32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0004843 ubiquitin-specific protease activity IBA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 24705354
GO:0036459 ubiquitinyl hydrolase activity --
genes like me logo Genes that share ontologies with USP32: view
genes like me logo Genes that share phenotypes with USP32: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP32

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for USP32 Gene

Localization for USP32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for USP32 Gene

Membrane; Lipid-anchor. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP32 Gene COMPARTMENTS Subcellular localization image for USP32 gene
Compartment Confidence
golgi apparatus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for USP32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA 20549504
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with USP32: view

Pathways & Interactions for USP32 Gene

genes like me logo Genes that share pathways with USP32: view

Pathways by source for USP32 Gene

Gene Ontology (GO) - Biological Process for USP32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0016579 protein deubiquitination TAS 20549504
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0061136 regulation of proteasomal protein catabolic process IBA --
genes like me logo Genes that share ontologies with USP32: view

No data available for SIGNOR curated interactions for USP32 Gene

Drugs & Compounds for USP32 Gene

(1) Additional Compounds for USP32 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with USP32: view

Transcripts for USP32 Gene

Unigene Clusters for USP32 Gene

Ubiquitin specific peptidase 32:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for USP32

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP32 Gene

No ASD Table

Relevant External Links for USP32 Gene

GeneLoc Exon Structure for
USP32
ECgene alternative splicing isoforms for
USP32

Expression for USP32 Gene

mRNA expression in normal human tissues for USP32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP32 Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for USP32 Gene

This gene is overexpressed in Testis (32.4), Lung (21.8), and Frontal cortex (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for USP32 Gene



SOURCE GeneReport for Unigene cluster for USP32 Gene Hs.132868

genes like me logo Genes that share expression patterns with USP32: view

Protein tissue co-expression partners for USP32 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for USP32 Gene

Orthologs for USP32 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for USP32 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia USP32 35
  • 91.19 (n)
  • 94.34 (a)
-- 36
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia USP32 35
  • 93.37 (n)
  • 96.97 (a)
-- 36
  • 94 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Usp32 35
  • 91.06 (n)
  • 95.76 (a)
Usp32 16
Usp32 36
  • 96 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Usp32 35
  • 90.77 (n)
  • 95.32 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia USP32 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves USP32 35
  • 80 (n)
  • 87.33 (a)
-- 36
  • 83 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia usp32 35
  • 75.69 (n)
  • 84.12 (a)
zebrafish
(Danio rerio)
Actinopterygii usp32 35
  • 69.97 (n)
  • 77.78 (a)
usp32 36
  • 77 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001209 35
  • 52.8 (n)
  • 49.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8334 35
  • 52.34 (n)
  • 49.09 (a)
CG8334 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyk-3 35
  • 45.87 (n)
  • 35.79 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBP12 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for USP32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for USP32 Gene

ENSEMBL:
Gene Tree for USP32 (if available)
TreeFam:
Gene Tree for USP32 (if available)

Paralogs for USP32 Gene

Paralogs for USP32 Gene

Pseudogenes.org Pseudogenes for USP32 Gene

genes like me logo Genes that share paralogs with USP32: view

Variants for USP32 Gene

Sequence variations from dbSNP and Humsavar for USP32 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs193204 -- 60,184,064(+) ggtgg(A/C)tcatg intron-variant
rs237954 -- 60,266,458(+) ATATT(C/G)AAAAC intron-variant
rs237955 -- 60,265,861(+) GTAGC(A/T)TAATG intron-variant
rs237956 -- 60,263,583(+) CATCT(A/T)ACATA intron-variant
rs237957 -- 60,262,519(+) CCTCC(A/G)TTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP32 Gene

Variant ID Type Subtype PubMed ID
nsv833504 CNV Gain 17160897
dgv3239n71 CNV Loss 21882294
esv2716087 CNV Deletion 23290073
esv2716088 CNV Deletion 23290073
nsv9581 CNV Loss 18304495
nsv507850 CNV Insertion 20534489
dgv3240n71 CNV Loss 21882294
nsv519929 CNV Loss 19592680
dgv535n67 CNV Gain 20364138
esv2438168 CNV Deletion 19546169
esv2667558 CNV Deletion 23128226
esv2716089 CNV Deletion 23290073
dgv559e199 CNV Deletion 23128226
esv22599 CNV Gain+Loss 19812545
nsv820574 CNV Deletion 20802225
nsv828078 CNV Loss 20364138
nsv828079 CNV Loss 20364138
esv2478804 CNV Deletion 19546169
esv2085161 CNV Deletion 18987734
esv2716090 CNV Deletion 23290073
esv24610 CNV Gain+Loss 19812545
nsv820735 CNV Duplication 20802225

Variation tolerance for USP32 Gene

Residual Variation Intolerance Score: 5.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP32 Gene

HapMap Linkage Disequilibrium report
USP32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP32 Gene

Disorders for USP32 Gene

Relevant External Links for USP32

Genetic Association Database (GAD)
USP32
Human Genome Epidemiology (HuGE) Navigator
USP32
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP32
genes like me logo Genes that share disorders with USP32: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP32 Gene

Publications for USP32 Gene

  1. The Tre2 (USP6) oncogene is a hominoid-specific gene. (PMID: 12604796) Paulding C.A. … Haber D.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 23 67
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 67
  3. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. (PMID: 23105109) Hayes S.D. … UrbAc S. (J. Biol. Chem. 2012) 67

Products for USP32 Gene

Sources for USP32 Gene

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