Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



USP32 Gene

protein-coding   GIFtS: 57
GCID: GC17M058254

Ubiquitin Specific Peptidase 32

(Previous name: ubiquitin specific protease 32)
  Search for USP32
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ubiquitin Specific Peptidase 321 2     Ubiquitin-Specific-Processing Protease 322 3
USP102 3 5     NY-REN-602
Ubiquitin Specific Protease 321 2     Ubiquitin Carboxyl-Terminal Hydrolase 322
Deubiquitinating Enzyme 322 3     Ubiquitin Thiolesterase 322
Renal Carcinoma Antigen NY-REN-602 3     EC 3.4.19.123
Ubiquitin Thioesterase 322 3     EC 3.1.2.158

External Ids:    HGNC: 191431   Entrez Gene: 846692   Ensembl: ENSG000001708327   OMIM: 6077405   UniProtKB: Q8NFA03   

Export aliases for USP32 gene to outside databases

Previous GC identifers: GC17M058596 GC17M058730 GC17M058729 GC17M055609 GC17M053625


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for USP32 Gene:
USP32 (ubiquitin specific peptidase 32) is a protein-coding gene. GO annotations related to this gene include cysteine-type peptidase activity and calcium ion binding. An important paralog of this gene is USP45.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP32 gene promoter:
         Nkx3-1   FOXD1   Lmo2   Nkx3-1 v1   LCR-F1   Nkx3-1 v2   FAC1   FOXJ2 (long isoform)   FOXJ2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP32 promoter sequence
   Search Chromatin IP Primers for USP32

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   Ensembl cytogenetic band:  17q23.2   HGNC cytogenetic band: 17q23.3

USP32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP32 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M058254:  view genomic region     (about GC identifiers)

Start:
58,254,691 bp from pter      End:
58,499,831 bp from pter
Size:
245,141 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UBP32_HUMAN, Q8NFA0 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 32 precursor  
Size: 1604 amino acids; 181656 Da
Secondary accessions: Q9BX85 Q9Y591

Explore the universe of human proteins at neXtProt for USP32: NX_Q8NFA0

Explore proteomics data for USP32 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys951
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for USP32 (Q8NFA0) (see all 6)
     NLGNTCF  FLLDGLH  LIIHLKR  GNTCFMN 


    See USP32 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115971.2  
    ENSEMBL proteins: 
     ENSP00000300896   ENSP00000467885   ENSP00000466740   ENSP00000465844   ENSP00000464762  
     ENSP00000465922   ENSP00000465659   ENSP00000376727   ENSP00000467098   ENSP00000467435  

    USP32 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for USP32
    GenScript Custom Purified and Recombinant Proteins Services for USP32
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP32

     
    Search eBioscience for Proteins for USP32 

    USP32 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for USP32
    OriGene Custom Antibody Services for USP32
    Novus Biologicals USP32 Antibodies
    Abcam antibodies for USP32
    Cloud-Clone Corp. Antibodies for USP32
    Search ThermoFisher Antibodies for USP32
    LSBio Antibodies in human, mouse, rat for USP32

    USP32 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for USP32
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP32
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP32
    Cloud-Clone Corp. CLIAs for USP32
    Search eBioscience for ELISAs for USP32 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    EFHAND: EF-hand domain containing
    USP: Ubiquitin-specific peptidases

    Selected InterPro protein domains (see all 9):
     IPR001125 Recoverin_like
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS

    Graphical View of Domain Structure for InterPro Entry Q8NFA0

    ProtoNet protein and cluster: Q8NFA0

    3 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB006615 Ubiquitin-specific protease DUSP
    IPB010460 Ubiquitin carboxyl-terminal hydrolase


    UniProtKB/Swiss-Prot: UBP32_HUMAN, Q8NFA0
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 DUSP domain
    Similarity: Contains 3 EF-hand domains
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP32           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP32_HUMAN, Q8NFA0
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IDA--
    GO:0004843ubiquitin-specific protease activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008234cysteine-type peptidase activity ----
         
    Find genes that share ontologies with USP32           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for USP32:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP32
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP32

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP32
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP32

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP32:
    hsa-mir-18a-3p (MIRT040883)

    Block miRNA regulation of human, mouse, rat USP32 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP32 (see all 67):
    hsa-miR-411 hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-3148 hsa-miR-192* hsa-miR-130b hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidUSP32 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP32
    Predesigned siRNA for gene silencing in human, mouse, rat USP32

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP32

    Clone
    Products:
         
    OriGene clones in human, mouse for USP32 (see all 7)
    OriGene ORF clones in mouse, rat for USP32
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP32 (NM_032582)
    Sino Biological Human cDNA Clone for USP32
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP32
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP32

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for USP32
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP32 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP32


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UBP32_HUMAN, Q8NFA0: Membrane; Lipid-anchor (Potential). Golgi apparatus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol3
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IDA--
    GO:0016020membrane IEA--

    Find genes that share ontologies with USP32           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for USP32 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP32
        Ubiquitin-Proteasome Dependent Proteolysis



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP32
    Interactions:

        Search GeneGlobe Interaction Network for USP32

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP32 (Q8NFA02, 3 ENSP000003008964) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCD3P282883, ENSP000003592334I2D: score=2 STRING: ENSP00000359233
    FARSAQ9Y2853, ENSP000003203094I2D: score=2 STRING: ENSP00000320309
    KRT18P057833, ENSP000003734874I2D: score=2 STRING: ENSP00000373487
    LRRC47Q8N1G43, ENSP000003674984I2D: score=2 STRING: ENSP00000367498
    SMC1AQ146833, ENSP000003234214I2D: score=2 STRING: ENSP00000323421
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016579protein deubiquitination TAS--

    Find genes that share ontologies with USP32           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP32 (UBP32)

    1 HMDB Compound for USP32    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for USP32 gene: 
    NM_032582.3  

    Unigene Cluster for USP32:

    Ubiquitin specific peptidase 32
    Hs.132868  [show with all ESTs]
    Unigene Representative Sequence: NM_032582
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300896(uc002iyn.1 uc002iyo.1) ENST00000592339 ENST00000593071
    ENST00000586238 ENST00000585720 ENST00000590133 ENST00000591768 ENST00000587651
    ENST00000589552 ENST00000589335 ENST00000393003(uc010wov.1) ENST00000588898
    ENST00000589761 ENST00000586881 ENST00000590297
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP32 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP32 (see all 67):
    hsa-miR-411 hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-3148 hsa-miR-192* hsa-miR-130b hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidUSP32 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for USP32
    Predesigned siRNA for gene silencing in human, mouse, rat USP32
    Clone
    Products:
         
    OriGene clones in human, mouse for USP32 (see all 7)
    OriGene ORF clones in mouse, rat for USP32
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP32 (NM_032582)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP32
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP32
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for USP32
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP32
      QuantiTect SYBR Green Assays in human, mouse, rat USP32
      QuantiFast Probe-based Assays in human, mouse, rat USP32

    Additional mRNA sequence: 

    AF155116.1 AF350251.1 AF533230.1 AK057301.1 AK091680.1 BC054344.1 BC070497.1 BC094680.1 

    16 DOTS entries:

    DT.102834044  DT.101968030  DT.95228000  DT.75149666  DT.70102880  DT.100824929  DT.95359688  DT.120938637 
    DT.92018144  DT.120976446  DT.40132939  DT.75199015  DT.95260532  DT.100037996  DT.120938700  DT.92054074 

    Selected AceView cDNA sequences (see all 212):

    F05676 BE464443 BU508524 AK057301 BQ716220 AF533230 AL121161 AW449838 
    CA314882 BM699167 BM676182 BU628355 BE672943 AI275601 NM_032582 AW268357 
    BM981195 W32505 BM669829 AA962478 BU166759 BU675536 BM793286 CA309893 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    USP32 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTAGCAGA
    USP32 Expression
    About this image


    USP32 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Testis (Reproductive System)
    USP32 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP32 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132868
        Custom PCR Arrays for USP32
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for USP32
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP32
    QuantiTect SYBR Green Assays in human, mouse, rat USP32
    QuantiFast Probe-based Assays in human, mouse, rat USP32
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP32

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP32 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp321 , 5 ubiquitin specific peptidase 321, 5 91.06(n)1
    95.76(a)1
      11 (51.34 cM)5
    2378981  NM_001029934.11  NP_001025105.11 
     849844425 
    chicken
    (Gallus gallus)
    Aves USP321 ubiquitin specific peptidase 32 80(n)
    87.33(a)
      417646  XM_004946740.1  XP_004946797.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Ubiquitin carboxyl-terminal hydrolase
    77(a)
    1 → many
    GL343393.1(400024-453166)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia usp321 ubiquitin specific peptidase 32 75.69(n)
    84.12(a)
      100487551  XM_002933823.2  XP_002933869.1 
    zebrafish
    (Danio rerio)
    Actinopterygii usp321 ubiquitin specific peptidase 32 69.97(n)
    77.78(a)
      557981  XM_681144.6  XP_686236.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG83341 CG8334 52.34(n)
    49.09(a)
      40169  NM_001275146.1  NP_001262075.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cyk-31 cyk-3 45.87(n)
    35.79(a)
      175853  NM_001027821.3  NP_001022992.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP126
    Ubiquitin carboxyl-terminal hydrolase, ubiquitin-s...
    20(a)
    1 → many
    X(63805-67569) YJL197W


    ENSEMBL Gene Tree for USP32 (if available)
    TreeFam Gene Tree for USP32 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for USP32 gene
    USP452  USP192  USP62  USP152  USP112  USP162  USP312  USP432  
    USP42  
    9 SIMAP similar genes for USP32 using alignment to 12 protein entries:     UBP32_HUMAN (see all proteins):
    USP6    USP6-short    tre    USP15    USP2    USP11
    VSNL1    NCALD    DKFZp761E10121

    Find genes that share paralogs with USP32           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for USP32
    PGOHUM00000250833


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for USP32 (see all 3811)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1909590331,2
    --58254254(+) AGTTCA/CCAATA 1 -- ds50010--------
    rs1177929861,2
    C,F--58254258(+) CACAAT/CAGGGT 1 -- ds50011Minor allele frequency- C:0.01NA 120
    rs3451761,2
    C,F,A,H--58254403(+) GCCACA/GGATGG 1 -- ds500116Minor allele frequency- G:0.26NS EA NA WA CSA 916
    rs1139356241,2
    C,F--58254409(+) GATGGT/CACTGG 1 -- ds50012Minor allele frequency- C:0.04NA 122
    rs1840453111,2
    --58254484(+) CCTCTC/GTAAGT 1 -- ds50010--------
    rs1435906351,2
    C--58254590(+) CGGCAC/TATGGA 1 -- ds50010--------
    rs1890261121,2
    --58254616(+) TAATTC/TGTTTG 1 -- ds50010--------
    rs1908268131,2
    --58254691(+) TATTTC/TGGTAC 1 -- ut310--------
    rs1828673221,2
    --58254823(+) AATTTC/TCTGCT 1 -- ut310--------
    rs1872045041,2
    --58254853(+) TTAATG/TACAAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for USP32 (58254691 - 58499831 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for USP32 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667558CNV Deletion23128226
    dgv559e199CNV Deletion23128226
    esv2438168CNV Deletion19546169
    esv2085161CNV Deletion18987734
    esv2716089CNV Deletion23290073
    esv2716088CNV Deletion23290073
    esv2716087CNV Deletion23290073
    esv2478804CNV Deletion19546169
    nsv820574CNV Deletion20802225
    esv2716090CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP32
    DNA2.0 Custom Variant and Variant Library Synthesis for USP32

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607740    OMIM disorders: --


    Find genes that share disorders with USP32           About GenesLikeMe

    Genetic Association Database (GAD): USP32
    Human Genome Epidemiology (HuGE) Navigator: USP32 (1 document)

    Export disorders for USP32 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for USP32 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with USP32)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Tre2 (USP6) oncogene is a hominoid-specific gene. (PubMed id 12604796)1, 2, 9 Paulding C.A.... Haber D.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. USP32 is an active, membrane-bound ubiquitin protease overexpressed in breast cancers. (PubMed id 20549504)1, 2 Akhavantabasi S....Erson A.E. (Mamm. Genome 2010)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    6. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    7. Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. (PubMed id 23105109)1 Hayes S.D....UrbAc S. (J. Biol. Chem. 2012)
    8. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 84669 HGNC: 19143 AceView: USP32 Ensembl:ENSG00000170832 euGenes: HUgn84669
    ECgene: USP32 H-InvDB: USP32

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for USP32 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for USP32 gene:
    Search GeneIP for patents involving USP32

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for USP32   OriGene RNAi products in human, mouse, rat for USP32  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for USP32  
     OriGene qSTAR qPCR primer pairs in human, mouse for USP32   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for USP32   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for USP32   OriGene Custom Protein Services for USP32  

     
     
     Block miRNA regulation of human, mouse, rat USP32 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing USP32
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP32 Predesigned siRNA for gene silencing in human, mouse, rat USP32
     QuantiFast Probe-based Assays in human, mouse, rat USP32 QuantiTect SYBR Green Assays in human, mouse, rat USP32
     Custom PCR Arrays for USP32 Search Chromatin IP Primers for USP32
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP32  Search GeneGlobe Interaction Network for USP32
     Regulatory tfbs in USP32 promoter
     GenScript Custom Purified and Recombinant Proteins Services for USP32 GenScript cDNA clones with any tag delivered in your preferred vector for USP32
     GenScript Custom Assay Services for USP32 GenScript Custom overexpressing Cell Line Services for USP32
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for USP32 (UBP32)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for USP32
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     USP32 antibodies
     Antibodies for USP32
     See all of Abcam's Antibodies, Kits and Proteins for USP32
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for USP32
     Antibodies for USP32
     ELISAs for USP32
     CLIAs for USP32



     Browse ESI BIO Cell Lines and PureStem Progenitors for USP32
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP32
     SwitchGear 3'UTR luciferase reporter plasmids for USP32
     SwitchGear Promoter luciferase reporter plasmids for USP32
     Search ThermoFisher Antibodies for USP32
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP32
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP32
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP32
     LSBio Antibodies in human, mouse, rat for USP32
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for USP32
      Search eBioscience for proteins for USP32
      Search eBioscience for elisas for USP32
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      USP32 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4