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Aliases for USP31 Gene

Aliases for USP31 Gene

  • Ubiquitin Specific Peptidase 31 2 3
  • Ubiquitin-Specific-Processing Protease 31 4
  • Ubiquitin Specific Protease 31 2
  • Deubiquitinating Enzyme 31 4
  • Ubiquitin Thioesterase 31 4
  • EC 3.4.19.12 4
  • EC 3.1.2.15 64
  • KIAA1203 4

External Ids for USP31 Gene

Summaries for USP31 Gene

GeneCards Summary for USP31 Gene

USP31 (Ubiquitin Specific Peptidase 31) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include ubiquitin thiolesterase activity and cysteine-type peptidase activity. An important paralog of this gene is USP4.

UniProtKB/Swiss-Prot for USP31 Gene

  • May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP31 Gene

Genomics for USP31 Gene

Genomic Location for USP31 Gene

Start:
23,061,406 bp from pter
End:
23,149,270 bp from pter
Size:
87,865 bases
Orientation:
Minus strand

Genomic View for USP31 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP31 Gene

Regulatory Elements for USP31 Gene

Proteins for USP31 Gene

  • Protein details for USP31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70CQ4-UBP31_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 31
    Protein Accession:
    Q70CQ4
    Secondary Accessions:
    • Q6AW97
    • Q6ZTC0
    • Q6ZTN2
    • Q9ULL7

    Protein attributes for USP31 Gene

    Size:
    1352 amino acids
    Molecular mass:
    146651 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK126752; Type=Frameshift; Positions=941; Evidence={ECO:0000305};

    Alternative splice isoforms for USP31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP31 Gene

Proteomics data for USP31 Gene at MOPED

Selected DME Specific Peptides for USP31 Gene

Post-translational modifications for USP31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP31 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for USP31 Gene

Gene Families for USP31 Gene

HGNC:
  • USP :Ubiquitin-specific peptidases

Protein Domains for USP31 Gene

UniProtKB/Swiss-Prot:

UBP31_HUMAN
Domain:
  • Contains 1 USP domain.:
    • Q70CQ4
Family:
  • Belongs to the peptidase C19 family.:
    • Q70CQ4
genes like me logo Genes that share domains with USP31: view

Function for USP31 Gene

Molecular function for USP31 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
UniProtKB/Swiss-Prot Function: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Enzyme Numbers (IUBMB) for USP31 Gene

Gene Ontology (GO) - Molecular Function for USP31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0004843 ubiquitin-specific protease activity IDA 16214042
GO:0036459 ubiquitinyl hydrolase activity --
genes like me logo Genes that share ontologies with USP31: view

Phenotypes for USP31 Gene

GenomeRNAi human phenotypes for USP31:
genes like me logo Genes that share phenotypes with USP31: view

miRNA for USP31 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for USP31 Gene

Localization for USP31 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP31 Gene COMPARTMENTS Subcellular localization image for USP31 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for USP31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16214042
genes like me logo Genes that share ontologies with USP31: view

Pathways for USP31 Gene

genes like me logo Genes that share pathways with USP31: view

Pathways by source for USP31 Gene

1 Qiagen pathway for USP31 Gene

Gene Ontology (GO) - Biological Process for USP31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0016579 protein deubiquitination IDA 16214042
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0061136 regulation of proteasomal protein catabolic process IBA --
genes like me logo Genes that share ontologies with USP31: view

Transcripts for USP31 Gene

Unigene Clusters for USP31 Gene

Ubiquitin specific peptidase 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP31 Gene

No ASD Table

Relevant External Links for USP31 Gene

GeneLoc Exon Structure for
USP31
ECgene alternative splicing isoforms for
USP31

Expression for USP31 Gene

mRNA expression in normal human tissues for USP31 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for USP31 Gene

SOURCE GeneReport for Unigene cluster for USP31 Gene Hs.183817

mRNA Expression by UniProt/SwissProt for USP31 Gene

Q70CQ4-UBP31_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with USP31: view

Orthologs for USP31 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP31 36
  • 98.87 (n)
  • 98.67 (a)
USP31 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia USP31 36
  • 88.99 (n)
  • 92.02 (a)
USP31 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia USP31 36
  • 91.27 (n)
  • 93.21 (a)
USP31 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Usp31 36
  • 87.16 (n)
  • 90.69 (a)
Usp31 16
Usp31 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia USP31 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 81 (a)
OneToMany
-- 37
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Usp31 36
  • 86.81 (n)
  • 91.26 (a)
chicken
(Gallus gallus)
Aves USP31 36
  • 74.27 (n)
  • 78.07 (a)
USP31 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia USP31 37
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32851 36
tropical clawed frog
(Silurana tropicalis)
Amphibia usp31 36
  • 64.65 (n)
  • 66.64 (a)
zebrafish
(Danio rerio)
Actinopterygii usp31 36
  • 63.36 (n)
  • 63.3 (a)
USP31 37
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30421 37
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToMany
Species with no ortholog for USP31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP31 Gene

ENSEMBL:
Gene Tree for USP31 (if available)
TreeFam:
Gene Tree for USP31 (if available)

Paralogs for USP31 Gene

Paralogs for USP31 Gene

Selected SIMAP similar genes for USP31 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with USP31: view

Variants for USP31 Gene

Sequence variations from dbSNP and Humsavar for USP31 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2010 -- 23,064,368(+) CTAAA(A/G)GCTGC utr-variant-3-prime
rs9564 -- 23,061,512(-) GAAAC(A/G)TTTTA utr-variant-3-prime
rs715368 -- 23,129,825(-) TCTTA(C/G)ATTAA intron-variant
rs717632 -- 23,067,475(-) TCTCA(A/G)GTATA utr-variant-3-prime
rs717633 -- 23,067,669(-) GCGTA(A/G)AAGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for USP31 Gene

Variant ID Type Subtype PubMed ID
nsv521703 CNV Gain 19592680
esv23899 CNV Loss 19812545

Relevant External Links for USP31 Gene

HapMap Linkage Disequilibrium report
USP31

Disorders for USP31 Gene

Relevant External Links for USP31

Human Genome Epidemiology (HuGE) Navigator
USP31
genes like me logo Genes that share disorders with USP31: view

No data available for UniProtKB/Swiss-Prot for USP31 Gene

Publications for USP31 Gene

  1. Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB. (PMID: 16214042) Tzimas C. … Hatzivassiliou E.G. (Cell. Signal. 2006) 3 23
  2. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  3. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 3 4

Products for USP31 Gene

Sources for USP31 Gene

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