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Aliases for USP31 Gene

Aliases for USP31 Gene

  • Ubiquitin Specific Peptidase 31 2 3 5
  • Ubiquitin-Specific-Processing Protease 31 4
  • Ubiquitin Specific Protease 31 2
  • Deubiquitinating Enzyme 31 4
  • Ubiquitin Thioesterase 31 4
  • EC 3.4.19.12 4
  • EC 3.1.2.15 61
  • KIAA1203 4

External Ids for USP31 Gene

Previous GeneCards Identifiers for USP31 Gene

  • GC01M021151
  • GC01M021474
  • GC16M023045
  • GC16M021162

Summaries for USP31 Gene

GeneCards Summary for USP31 Gene

USP31 (Ubiquitin Specific Peptidase 31) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP43.

UniProtKB/Swiss-Prot for USP31 Gene

  • May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP31 Gene

Genomics for USP31 Gene

Regulatory Elements for USP31 Gene

Enhancers for USP31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F023141 1.1 Ensembl ENCODE 20.7 +3.6 3566 8.9 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 USP31 COG7 ENSG00000260751 SCNN1G ENSG00000260482 PIR56769
GH16F023119 1.2 Ensembl ENCODE 20.3 +28.7 28699 2.7 RING1 SOX13 TFAP4 PKNOX1 ZNF146 FEZF1 ZNF384 GATA3 SCRT2 ZNF362 USP31 COG7 MFSD13B NPIPB5 ENSG00000260905 PIR56769
GH16F023103 0.6 ENCODE 20.2 +44.8 44794 1.2 ELF3 TBP ATF1 ARID4B DMAP1 THRB ZSCAN9 RAD21 RARA YY1 USP31 ENSG00000260751 SMG1P1 GC16P023106 GC16M023077
GH16F023079 0.2 ENCODE 19.9 +67.9 67944 2.9 ELF3 PKNOX1 ARID4B THRB RAD21 ZNF48 YY1 RARA FOS CREM USP31 GC16M023077 ENSG00000260566
GH16F023123 0.8 Ensembl ENCODE 19.8 +24.4 24371 2.6 ZNF362 JUN ZNF384 NR3C1 JUND ZNF274 ZNF692 SCRT2 FOS ZNF600 USP31 PIR56769
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around USP31 on UCSC Golden Path with GeneCards custom track

Promoters for USP31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000505414 470 3200 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for USP31 Gene

Chromosome:
16
Start:
23,061,406 bp from pter
End:
23,149,270 bp from pter
Size:
87,865 bases
Orientation:
Minus strand

Genomic View for USP31 Gene

Genes around USP31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP31 Gene

Proteins for USP31 Gene

  • Protein details for USP31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70CQ4-UBP31_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 31
    Protein Accession:
    Q70CQ4
    Secondary Accessions:
    • Q6AW97
    • Q6ZTC0
    • Q6ZTN2
    • Q9ULL7

    Protein attributes for USP31 Gene

    Size:
    1352 amino acids
    Molecular mass:
    146651 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK126752; Type=Frameshift; Positions=941; Evidence={ECO:0000305};

    Alternative splice isoforms for USP31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for USP31 Gene

Selected DME Specific Peptides for USP31 Gene

Q70CQ4:
  • GNTCFMN
  • LIIHLKR

Post-translational modifications for USP31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP31 Gene

Domains & Families for USP31 Gene

Gene Families for USP31 Gene

Protein Domains for USP31 Gene

Suggested Antigen Peptide Sequences for USP31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q70CQ4

UniProtKB/Swiss-Prot:

UBP31_HUMAN :
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
Domain:
  • Contains 1 USP domain.
Family:
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP31: view

Function for USP31 Gene

Molecular function for USP31 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Enzyme Numbers (IUBMB) for USP31 Gene

Gene Ontology (GO) - Molecular Function for USP31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 16214042
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with USP31: view
genes like me logo Genes that share phenotypes with USP31: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP31 Gene

Localization for USP31 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for USP31 Gene COMPARTMENTS Subcellular localization image for USP31 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for USP31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16214042
genes like me logo Genes that share ontologies with USP31: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for USP31 Gene

Pathways & Interactions for USP31 Gene

genes like me logo Genes that share pathways with USP31: view

Pathways by source for USP31 Gene

1 Qiagen pathway for USP31 Gene

Gene Ontology (GO) - Biological Process for USP31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016579 protein deubiquitination IEA,IDA 16214042
genes like me logo Genes that share ontologies with USP31: view

No data available for SIGNOR curated interactions for USP31 Gene

Transcripts for USP31 Gene

Unigene Clusters for USP31 Gene

Ubiquitin specific peptidase 31:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for USP31 Gene

No ASD Table

Relevant External Links for USP31 Gene

GeneLoc Exon Structure for
USP31
ECgene alternative splicing isoforms for
USP31

Expression for USP31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for USP31 Gene

Protein differential expression in normal tissues from HIPED for USP31 Gene

This gene is overexpressed in Bone (51.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for USP31 Gene



Protein tissue co-expression partners for USP31 Gene

NURSA nuclear receptor signaling pathways regulating expression of USP31 Gene:

USP31

SOURCE GeneReport for Unigene cluster for USP31 Gene:

Hs.183817

mRNA Expression by UniProt/SwissProt for USP31 Gene:

Q70CQ4-UBP31_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with USP31: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for USP31 Gene

Orthologs for USP31 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia USP31 34 35
  • 98.87 (n)
dog
(Canis familiaris)
Mammalia USP31 34 35
  • 91.27 (n)
cow
(Bos Taurus)
Mammalia USP31 34 35
  • 88.99 (n)
mouse
(Mus musculus)
Mammalia Usp31 34 16 35
  • 87.16 (n)
rat
(Rattus norvegicus)
Mammalia Usp31 34
  • 86.81 (n)
oppossum
(Monodelphis domestica)
Mammalia USP31 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves USP31 34 35
  • 74.27 (n)
lizard
(Anolis carolinensis)
Reptilia USP31 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia usp31 34
  • 64.65 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32851 34
zebrafish
(Danio rerio)
Actinopterygii usp31 34
  • 63.36 (n)
USP31 35
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30421 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for USP31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP31 Gene

ENSEMBL:
Gene Tree for USP31 (if available)
TreeFam:
Gene Tree for USP31 (if available)

Paralogs for USP31 Gene

Paralogs for USP31 Gene

(3) SIMAP similar genes for USP31 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with USP31: view

Variants for USP31 Gene

Sequence variations from dbSNP and Humsavar for USP31 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10083789 -- 23,069,313(+) CACGG(A/C)GACTA nc-transcript-variant, reference, missense
rs10083815 -- 23,071,311(+) CTGAG(A/C)CTTGT intron-variant
rs1029364 -- 23,116,246(-) TTGTC(C/T)TCCTG intron-variant
rs10451083 -- 23,137,867(+) AGCAA(A/T)GTGAT intron-variant
rs1045195 -- 23,066,030(-) ACAGC(C/T)CCATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for USP31 Gene

Variant ID Type Subtype PubMed ID
dgv1321n106 CNV deletion 24896259
dgv4954n54 CNV loss 21841781
dgv4955n54 CNV gain+loss 21841781
dgv4956n54 CNV loss 21841781
dgv4957n54 CNV gain 21841781
esv23899 CNV loss 19812545
nsv1071277 CNV deletion 25765185
nsv521703 CNV gain 19592680
nsv571674 CNV loss 21841781
nsv571687 CNV loss 21841781
nsv571688 CNV loss 21841781
nsv952954 CNV deletion 24416366

Variation tolerance for USP31 Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.22; 94.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for USP31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
USP31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP31 Gene

Disorders for USP31 Gene

Relevant External Links for USP31

Human Genome Epidemiology (HuGE) Navigator
USP31
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
USP31

No disorders were found for USP31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP31 Gene

Publications for USP31 Gene

  1. Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB. (PMID: 16214042) Tzimas C. … Hatzivassiliou E.G. (Cell. Signal. 2006) 3 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 3 4 64
  4. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3 64
  5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4 64

Products for USP31 Gene

Sources for USP31 Gene

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