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USP31 Gene

protein-coding   GIFtS: 50
GCID: GC16M022986

Ubiquitin Specific Peptidase 31

(Previous name: ubiquitin specific protease 31)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 311 2     Ubiquitin Specific Proteinase 312
Ubiquitin Specific Protease 311 2     Ubiquitin Thiolesterase 312
Deubiquitinating Enzyme 312 3     EC 3.4.19.123
Ubiquitin Thioesterase 312 3     KIAA12033
Ubiquitin-Specific-Processing Protease 312 3     EC 3.1.2.158
Ubiquitin Carboxyl-Terminal Hydrolase 312     

External Ids:    HGNC: 200601   Entrez Gene: 574782   Ensembl: ENSG000001034047   UniProtKB: Q70CQ43   

Export aliases for USP31 gene to outside databases

Previous GC identifers: GC01M021151 GC01M021474 GC16M023045 GC16M021162


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for USP31 Gene:
USP31 (ubiquitin specific peptidase 31) is a protein-coding gene. GO annotations related to this gene include cysteine-type peptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP45.

UniProtKB/Swiss-Prot: UBP31_HUMAN, Q70CQ4
Function: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the
processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP31 gene promoter:
         SREBP-1c   Pax-2   Nkx2-5   AP-4   SREBP-1b   Meis-1b   SREBP-1a   Meis-1a   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP31 promoter sequence
   Search Chromatin IP Primers for USP31

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP31


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.2   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12.3

USP31 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP31 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M022986:  view genomic region     (about GC identifiers)

Start:
23,072,727 bp from pter      End:
23,160,591 bp from pter
Size:
87,865 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBP31_HUMAN, Q70CQ4 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 31  
Size: 1352 amino acids; 146651 Da
Sequence caution: Sequence=AK126752; Type=Frameshift; Positions=941;
Secondary accessions: Q6AW97 Q6ZTC0 Q6ZTN2 Q9ULL7
Alternative splicing: 2 isoforms:  Q70CQ4-1   Q70CQ4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP31: NX_Q70CQ4

Explore proteomics data for USP31 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for USP31 (Q70CQ4)
     LIIHLKR  GNTCFMN 


    See USP31 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065769.3  
    ENSEMBL proteins: 
     ENSP00000219689   ENSP00000461621  

    USP31 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for USP31
    OriGene Custom MassSpec
    OriGene Custom Protein Services for USP31
    GenScript Custom Purified and Recombinant Proteins Services for USP31
    Novus Biologicals USP31 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP31

     
    Search eBioscience for Proteins for USP31 

     
    antibodies-online proteins for USP31 (2 products) 

     
    Search antibodies-online for peptides for USP31

    USP31 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals USP31 Antibodies
    Abcam antibodies for USP31
    Cloud-Clone Corp. Antibodies for USP31
    Search ThermoFisher Antibodies for USP31
    antibodies-online antibodies for USP31 (13 products) 

    USP31 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for USP31
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP31
    Cloud-Clone Corp. CLIAs for USP31
    Search eBioscience for ELISAs for USP31 
    antibodies-online kits for USP31 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    3 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR028889 UCH/PAN2

    Graphical View of Domain Structure for InterPro Entry Q70CQ4

    ProtoNet protein and cluster: Q70CQ4

    1 Blocks protein domain: IPB001394 Ubiquitin thiolesterase

    UniProtKB/Swiss-Prot: UBP31_HUMAN, Q70CQ4
    Similarity: Belongs to the peptidase C19 family
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP31           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP31_HUMAN, Q70CQ4
    Function: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the
    processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity)
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity ----
    GO:0004843ubiquitin-specific protease activity IDA16214042
    GO:0008234cysteine-type peptidase activity ----
         
    Find genes that share ontologies with USP31           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for USP31:
     G2 arrest  Increased S DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for USP31

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP31:
    hsa-mir-92a-3p (MIRT049205), hsa-mir-7-5p (MIRT025942), hsa-mir-23b-3p (MIRT046371), hsa-mir-375 (MIRT020046), hsa-mir-574-3p (MIRT040520)

    Block miRNA regulation of human, mouse, rat USP31 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP31 (see all 115):
    hsa-miR-124* hsa-miR-15a hsa-miR-106a hsa-miR-218-1* hsa-miR-938 hsa-miR-519a hsa-miR-4325 hsa-miR-93
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for USP31
    Predesigned siRNA for gene silencing in human, mouse, rat USP31

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for USP31

    Clone
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    OriGene clones in human, mouse for USP31 (see all 7)
    OriGene ORF clones in mouse, rat for USP31
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP31 (NM_020718)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP31
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP31

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for USP31 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP31


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16214042

    Find genes that share ontologies with USP31           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP31 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP31
        Ubiquitin-Proteasome Dependent Proteolysis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for USP31
    Interactions:

        GeneGlobe Interaction Network for USP31

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for USP31 (Q70CQ43 ENSP000002196894) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    TRAF2Q129333, ENSP000002476684I2D: score=1 STRING: ENSP00000247668
    USP21ENSP000002898654STRING: ENSP00000289865
    MCM3APENSP000002916884STRING: ENSP00000291688
    PLAAENSP000003804604STRING: ENSP00000380460
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016579protein deubiquitination IDA16214042

    Find genes that share ontologies with USP31           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP31 (UBP31)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP31 gene: 
    NM_020718.3  

    Unigene Cluster for USP31:

    Ubiquitin specific peptidase 31
    Hs.183817  [show with all ESTs]
    Unigene Representative Sequence: NM_020718
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000219689(uc002dlk.3 uc010vca.2 uc010bxm.3 uc002dll.3)
    ENST00000567975 ENST00000381162 ENST00000563525
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP31 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP31 (see all 115):
    hsa-miR-124* hsa-miR-15a hsa-miR-106a hsa-miR-218-1* hsa-miR-938 hsa-miR-519a hsa-miR-4325 hsa-miR-93
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for USP31
    Predesigned siRNA for gene silencing in human, mouse, rat USP31
    Clone
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    OriGene clones in human, mouse for USP31 (see all 7)
    OriGene ORF clones in mouse, rat for USP31
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP31 (NM_020718)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP31
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP31
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for USP31
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP31
      QuantiTect SYBR Green Assays in human, mouse, rat USP31
      QuantiFast Probe-based Assays in human, mouse, rat USP31

    Additional mRNA sequence: 

    AB033029.1 AJ586135.2 AK057491.1 AK092790.1 AK126752.1 U52050.1 

    5 DOTS entries:

    DT.101980244  DT.91901673  DT.92425946  DT.99928034  DT.95129569 

    Selected AceView cDNA sequences (see all 159):

    AI168312 BX648357 BX115399 AI468650 AI342753 CB242222 H82214 CD246092 
    AB033029 BF939930 BQ050792 BQ012996 AI783638 AV725490 AI187852 BU683258 
    AI081360 T27102 AA995097 BF512220 BQ948537 F10465 AW440572 AV725025 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    USP31 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATGTGTCA
    USP31 Expression
    About this image

    USP31 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP31 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.183817

    UniProtKB/Swiss-Prot: UBP31_HUMAN, Q70CQ4
    Tissue specificity: Widely expressed

        Custom PCR Arrays for USP31
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP31

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for USP31 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp311 , 5 ubiquitin specific peptidase 311, 5 87.16(n)1
    90.69(a)1
      7 (65.07 cM)5
    761791  NM_001033173.11  NP_001028345.11 
     1216420215 
    chicken
    (Gallus gallus)
    Aves USP311 ubiquitin specific peptidase 31 74.27(n)
    78.07(a)
      416580  XM_003642146.2  XP_003642194.2 
    lizard
    (Anolis carolinensis)
    Reptilia USP316
    ubiquitin specific peptidase 31
    69(a)
    1 ↔ 1
    GL343936.1(57174-102118)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.328512 Xenopus laevis transcribed sequence with weak similarity more 76.79(n)    BJ627030.1 
    zebrafish
    (Danio rerio)
    Actinopterygii usp311 ubiquitin specific peptidase 31 63.36(n)
    63.3(a)
      564487  XM_005164229.1  XP_005164286.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG304216
    --
    26(a)
    1 → many
    2R(20631335-20644501)


    ENSEMBL Gene Tree for USP31 (if available)
    TreeFam Gene Tree for USP31 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP31 gene
    USP452  USP192  USP62  USP152  USP112  USP162  USP432  USP322  
    USP42  
    3 SIMAP similar genes for USP31 using alignment to 2 protein entries:     UBP31_HUMAN (see all proteins):
    USP15    USP43    USP11

    Find genes that share paralogs with USP31           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP31 (see all 1806)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1863260561,2
    --23072252(+) TCAGTA/TGGGAG 1 -- ds50010--------
    rs1161654801,2
    C,F--23072272(+) GAAGGG/ATGGGA 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1912722651,2
    --23072686(+) ACCAAA/GAAGAT 1 -- ds50010--------
    rs1826779421,2
    --23072693(+) AGATAA/TCAGTT 1 -- ds50010--------
    rs1867370491,2
    --23072694(+) GATATC/TAGTTG 1 -- ds50010--------
    rs1899650001,2
    --23072779(+) CCACTC/TTTCTC 1 -- ut310--------
    rs1404809151,2
    C--23072780(+) CACTT-/TTCTC 
            
    TTAAT
    1 -- ut310--------
    rs768888921,2
    C--23072803(+) TATACC/TATATA 1 -- ut310--------
    rs791569981,2
    C--23072804(+) ATACTA/CTATAA 1 -- ut310--------
    rs1473117501,2
    C--23072805(+) TACTAC/TATAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for USP31 (23072727 - 23160591 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for USP31:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv23899CNV Loss19812545
    nsv521703CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP31
    DNA2.0 Custom Variant and Variant Library Synthesis for USP31

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with USP31           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: USP31 (1 document)

    Export disorders for USP31 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP31 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with USP31)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004)
    3. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    5. Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB. (PubMed id 16214042)1, 9 Tzimas C....Hatzivassiliou E.G. (Cell. Signal. 2006)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
    9. Identification of the human ubiquitin specific protease 31 (USP31) gene: structure, sequence and expression analysis. (PubMed id 15354349)1 Lockhart P.J.... Farrer M.J. (DNA Seq. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57478 HGNC: 20060 AceView: USP31 Ensembl:ENSG00000103404 euGenes: HUgn57478
    ECgene: USP31 H-InvDB: USP31

    (According to HUGE)
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    HUGE: KIAA1203

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for USP31 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for USP31 gene:
    Search GeneIP for patents involving USP31

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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