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Aliases for USP31 Gene

Aliases for USP31 Gene

  • Ubiquitin Specific Peptidase 31 2 3 5
  • Ubiquitin-Specific-Processing Protease 31 4
  • Ubiquitin Specific Protease 31 2
  • Deubiquitinating Enzyme 31 4
  • Ubiquitin Thioesterase 31 4
  • EC 4
  • EC 63
  • KIAA1203 4

External Ids for USP31 Gene

Previous GeneCards Identifiers for USP31 Gene

  • GC01M021151
  • GC01M021474
  • GC16M023045
  • GC16M021162

Summaries for USP31 Gene

GeneCards Summary for USP31 Gene

USP31 (Ubiquitin Specific Peptidase 31) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP4.

UniProtKB/Swiss-Prot for USP31 Gene

  • May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP31 Gene

Genomics for USP31 Gene

Regulatory Elements for USP31 Gene

Enhancers for USP31 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around USP31 on UCSC Golden Path with GeneCards custom track

Promoters for USP31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around USP31 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP31 Gene

23,061,406 bp from pter
23,149,270 bp from pter
87,865 bases
Minus strand

Genomic View for USP31 Gene

Genes around USP31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP31 Gene

Proteins for USP31 Gene

  • Protein details for USP31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 31
    Protein Accession:
    Secondary Accessions:
    • Q6AW97
    • Q6ZTC0
    • Q6ZTN2
    • Q9ULL7

    Protein attributes for USP31 Gene

    1352 amino acids
    Molecular mass:
    146651 Da
    Quaternary structure:
    No Data Available
    • Sequence=AK126752; Type=Frameshift; Positions=941; Evidence={ECO:0000305};

    Alternative splice isoforms for USP31 Gene


neXtProt entry for USP31 Gene

Proteomics data for USP31 Gene at MOPED

Selected DME Specific Peptides for USP31 Gene

Post-translational modifications for USP31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP31 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for USP31 Gene

Gene Families for USP31 Gene

Protein Domains for USP31 Gene

Suggested Antigen Peptide Sequences for USP31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP31: view

Function for USP31 Gene

Molecular function for USP31 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Enzyme Numbers (IUBMB) for USP31 Gene

genes like me logo Genes that share phenotypes with USP31: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP31 Gene

Localization for USP31 Gene

Subcellular locations from

Jensen Localization Image for USP31 Gene COMPARTMENTS Subcellular localization image for USP31 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP31 Gene

Pathways & Interactions for USP31 Gene

genes like me logo Genes that share pathways with USP31: view

Pathways by source for USP31 Gene

1 Qiagen pathway for USP31 Gene

Gene Ontology (GO) - Biological Process for USP31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with USP31: view

No data available for SIGNOR curated interactions for USP31 Gene

Drugs & Compounds for USP31 Gene

No Compound Related Data Available

Transcripts for USP31 Gene

Unigene Clusters for USP31 Gene

Ubiquitin specific peptidase 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP31 Gene

No ASD Table

Relevant External Links for USP31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP31 Gene

mRNA expression in normal human tissues for USP31 Gene

Protein differential expression in normal tissues from HIPED for USP31 Gene

This gene is overexpressed in Bone (51.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for USP31 Gene

SOURCE GeneReport for Unigene cluster for USP31 Gene Hs.183817

mRNA Expression by UniProt/SwissProt for USP31 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with USP31: view

Protein tissue co-expression partners for USP31 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for USP31 Gene

Orthologs for USP31 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP31 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia USP31 35
  • 88.99 (n)
  • 92.02 (a)
USP31 36
  • 93 (a)
(Canis familiaris)
Mammalia USP31 35
  • 91.27 (n)
  • 93.21 (a)
USP31 36
  • 93 (a)
(Mus musculus)
Mammalia Usp31 35
  • 87.16 (n)
  • 90.69 (a)
Usp31 16
Usp31 36
  • 92 (a)
(Pan troglodytes)
Mammalia USP31 35
  • 98.87 (n)
  • 98.67 (a)
USP31 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Usp31 35
  • 86.81 (n)
  • 91.26 (a)
(Monodelphis domestica)
Mammalia USP31 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
-- 36
  • 71 (a)
(Gallus gallus)
Aves USP31 35
  • 74.27 (n)
  • 78.07 (a)
USP31 36
  • 75 (a)
(Anolis carolinensis)
Reptilia USP31 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia usp31 35
  • 64.65 (n)
  • 66.64 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32851 35
(Danio rerio)
Actinopterygii usp31 35
  • 63.36 (n)
  • 63.3 (a)
USP31 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30421 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
Species with no ortholog for USP31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP31 Gene

Gene Tree for USP31 (if available)
Gene Tree for USP31 (if available)

Paralogs for USP31 Gene

Paralogs for USP31 Gene

(3) SIMAP similar genes for USP31 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with USP31: view

Variants for USP31 Gene

Sequence variations from dbSNP and Humsavar for USP31 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1978066 - 23,090,706(-) AAATG(G/T)ATTCT reference, missense
rs4597335 - 23,087,118(-) AAGGG(A/C/G/T)TGCTC reference, missense
rs13339649 - 23,087,101(+) CTACT(A/G)TTGGG reference, missense
rs9932912 - 23,085,631(+) ATGAG(C/T)AGTGC reference, missense
rs10083789 - 23,069,313(+) CACGG(A/C)GACTA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for USP31 Gene

Variant ID Type Subtype PubMed ID
nsv521703 CNV Gain 19592680
esv23899 CNV Loss 19812545

Variation tolerance for USP31 Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.22; 94.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for USP31 Gene

Disorders for USP31 Gene

Relevant External Links for USP31

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for USP31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP31 Gene

Publications for USP31 Gene

  1. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 3 4 67
  2. Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB. (PMID: 16214042) Tzimas C. … Hatzivassiliou E.G. (Cell. Signal. 2006) 3 23
  3. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for USP31 Gene

Sources for USP31 Gene