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Aliases for USP31 Gene

Aliases for USP31 Gene

  • Ubiquitin Specific Peptidase 31 2 3
  • Ubiquitin-Specific-Processing Protease 31 4
  • Ubiquitin Specific Protease 31 2
  • Deubiquitinating Enzyme 31 4
  • Ubiquitin Thioesterase 31 4
  • EC 4
  • EC 63
  • KIAA1203 4

External Ids for USP31 Gene

Previous GeneCards Identifiers for USP31 Gene

  • GC01M021151
  • GC01M021474
  • GC16M023045
  • GC16M021162

Summaries for USP31 Gene

GeneCards Summary for USP31 Gene

USP31 (Ubiquitin Specific Peptidase 31) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include ubiquitin thiolesterase activity and cysteine-type peptidase activity. An important paralog of this gene is USP4.

UniProtKB/Swiss-Prot for USP31 Gene

  • May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP31 Gene

Genomics for USP31 Gene

Regulatory Elements for USP31 Gene

Genomic Location for USP31 Gene

23,061,406 bp from pter
23,149,270 bp from pter
87,865 bases
Minus strand

Genomic View for USP31 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for USP31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP31 Gene

Proteins for USP31 Gene

  • Protein details for USP31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 31
    Protein Accession:
    Secondary Accessions:
    • Q6AW97
    • Q6ZTC0
    • Q6ZTN2
    • Q9ULL7

    Protein attributes for USP31 Gene

    1352 amino acids
    Molecular mass:
    146651 Da
    Quaternary structure:
    No Data Available
    • Sequence=AK126752; Type=Frameshift; Positions=941; Evidence={ECO:0000305};

    Alternative splice isoforms for USP31 Gene


neXtProt entry for USP31 Gene

Proteomics data for USP31 Gene at MOPED

Selected DME Specific Peptides for USP31 Gene

Post-translational modifications for USP31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP31 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for USP31 Gene

Gene Families for USP31 Gene

  • USP :Ubiquitin-specific peptidases

Protein Domains for USP31 Gene

Suggested Antigen Peptide Sequences for USP31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q70CQ4
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP31: view

Function for USP31 Gene

Molecular function for USP31 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
UniProtKB/Swiss-Prot Function: May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Enzyme Numbers (IUBMB) for USP31 Gene

Gene Ontology (GO) - Molecular Function for USP31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0004843 ubiquitin-specific protease activity IDA 16214042
GO:0036459 ubiquitinyl hydrolase activity --
genes like me logo Genes that share ontologies with USP31: view

Phenotypes for USP31 Gene

GenomeRNAi human phenotypes for USP31:
genes like me logo Genes that share phenotypes with USP31: view

miRNA for USP31 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for USP31 Gene

Localization for USP31 Gene

Subcellular locations from

Jensen Localization Image for USP31 Gene COMPARTMENTS Subcellular localization image for USP31 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for USP31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16214042
genes like me logo Genes that share ontologies with USP31: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for USP31 Gene

Pathways for USP31 Gene

genes like me logo Genes that share pathways with USP31: view

Pathways by source for USP31 Gene

1 Qiagen pathway for USP31 Gene

Gene Ontology (GO) - Biological Process for USP31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0016579 protein deubiquitination IDA 16214042
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0061136 regulation of proteasomal protein catabolic process IBA --
genes like me logo Genes that share ontologies with USP31: view

Transcripts for USP31 Gene

Unigene Clusters for USP31 Gene

Ubiquitin specific peptidase 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP31 Gene

No ASD Table

Relevant External Links for USP31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP31 Gene

mRNA expression in normal human tissues for USP31 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for USP31 Gene

SOURCE GeneReport for Unigene cluster for USP31 Gene Hs.183817

mRNA Expression by UniProt/SwissProt for USP31 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with USP31: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for USP31 Gene

Orthologs for USP31 Gene

This gene was present in the common ancestor of animals.

Orthologs for USP31 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia USP31 35
  • 98.87 (n)
  • 98.67 (a)
USP31 36
  • 99 (a)
(Bos Taurus)
Mammalia USP31 35
  • 88.99 (n)
  • 92.02 (a)
USP31 36
  • 93 (a)
(Canis familiaris)
Mammalia USP31 35
  • 91.27 (n)
  • 93.21 (a)
USP31 36
  • 93 (a)
(Mus musculus)
Mammalia Usp31 35
  • 87.16 (n)
  • 90.69 (a)
Usp31 16
Usp31 36
  • 92 (a)
(Monodelphis domestica)
Mammalia USP31 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
-- 36
  • 71 (a)
(Rattus norvegicus)
Mammalia Usp31 35
  • 86.81 (n)
  • 91.26 (a)
(Gallus gallus)
Aves USP31 35
  • 74.27 (n)
  • 78.07 (a)
USP31 36
  • 75 (a)
(Anolis carolinensis)
Reptilia USP31 36
  • 69 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32851 35
tropical clawed frog
(Silurana tropicalis)
Amphibia usp31 35
  • 64.65 (n)
  • 66.64 (a)
(Danio rerio)
Actinopterygii usp31 35
  • 63.36 (n)
  • 63.3 (a)
USP31 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30421 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
Species with no ortholog for USP31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP31 Gene

Gene Tree for USP31 (if available)
Gene Tree for USP31 (if available)

Paralogs for USP31 Gene

Paralogs for USP31 Gene

Selected SIMAP similar genes for USP31 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with USP31: view

Variants for USP31 Gene

Sequence variations from dbSNP and Humsavar for USP31 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2010 -- 23,064,368(+) CTAAA(A/G)GCTGC utr-variant-3-prime
rs9564 -- 23,061,512(-) GAAAC(A/G)TTTTA utr-variant-3-prime
rs715368 -- 23,129,825(-) TCTTA(C/G)ATTAA intron-variant
rs717632 -- 23,067,475(-) TCTCA(A/G)GTATA utr-variant-3-prime
rs717633 -- 23,067,669(-) GCGTA(A/G)AAGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for USP31 Gene

Variant ID Type Subtype PubMed ID
nsv521703 CNV Gain 19592680
esv23899 CNV Loss 19812545

Relevant External Links for USP31 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for USP31 Gene

Disorders for USP31 Gene

Relevant External Links for USP31

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with USP31: view

No data available for UniProtKB/Swiss-Prot for USP31 Gene

Publications for USP31 Gene

  1. Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB. (PMID: 16214042) Tzimas C. … Hatzivassiliou E.G. (Cell. Signal. 2006) 3 23
  2. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  3. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PMID: 14715245) Quesada V. … Lopez-Otin C. (Biochem. Biophys. Res. Commun. 2004) 3 4

Products for USP31 Gene

Sources for USP31 Gene

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