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USP3 Gene

protein-coding   GIFtS: 57
GCID: GC15P063796

Ubiquitin Specific Peptidase 3

(Previous name: ubiquitin specific protease 3)
  Search for USP3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Specific Peptidase 31 2     UBP2
Deubiquitinating Enzyme 32 3     Ubiquitin Carboxyl-Terminal Hydrolase 32
Ubiquitin Thioesterase 32 3     Ubiquitin Thiolesterase 32
Ubiquitin-Specific-Processing Protease 32 3     EC 3.4.19.123
Ubiquitin Specific Protease 31     EC 3.1.2.158
SIH0032     

External Ids:    HGNC: 126261   Entrez Gene: 99602   Ensembl: ENSG000001404557   OMIM: 6047285   UniProtKB: Q9Y6I43   

Export aliases for USP3 gene to outside databases

Previous GC identifers: GC15P059583 GC15P056887 GC15P061375 GC15P061512 GC15P061511 GC15P061582 GC15P040621


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for USP3 Gene:
USP3 (ubiquitin specific peptidase 3) is a protein-coding gene. GO annotations related to this gene include ubiquitin-specific protease activity and ubiquitin thiolesterase activity. An important paralog of this gene is USP44.

UniProtKB/Swiss-Prot: UBP3_HUMAN, Q9Y6I4
Function: Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required
for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR)
checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the USP3 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUSP3 promoter sequence
   Search Chromatin IP Primers for USP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat USP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.3   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.3

USP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USP3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P063796:  view genomic region     (about GC identifiers)

Start:
63,796,793 bp from pter      End:
63,886,839 bp from pter
Size:
90,047 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBP3_HUMAN, Q9Y6I4 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase 3  
Size: 520 amino acids; 58897 Da
Subunit: Interacts (via UBP-type domain) with H2A; the interaction is less efficient than with monoubiquitinated
H2A
Sequence caution: Sequence=AAD42992.1; Type=Frameshift; Positions=265, 274, 299;
Secondary accessions: B4DVU5 F5H1A6 Q8WVD0
Alternative splicing: 2 isoforms:  Q9Y6I4-1   Q9Y6I4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for USP3: NX_Q9Y6I4

Explore proteomics data for USP3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys107, Lys354, Lys423
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for USP3 (Q9Y6I4)
     NLGNTCF  AVVVHHG  GNTCFMN  QQDAHEF 


    See USP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243631.1  NP_006528.2  

    ENSEMBL proteins: 
     ENSP00000453688   ENSP00000453194   ENSP00000369681   ENSP00000454043   ENSP00000452929  
     ENSP00000453767   ENSP00000453228   ENSP00000453093   ENSP00000454197   ENSP00000453619  
     ENSP00000452947   ENSP00000445793   ENSP00000453138   ENSP00000453489   ENSP00000445828  
     ENSP00000445615   ENSP00000268049   ENSP00000445642  

    USP3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for USP3
    OriGene Protein Over-expression Lysate for USP3
    OriGene MassSpec for USP3
    OriGene Custom Protein Services for USP3
    GenScript Custom Purified and Recombinant Proteins Services for USP3
    Novus Biologicals USP3 Proteins
    Novus Biologicals USP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for USP3

     
    Search eBioscience for Proteins for USP3 

    USP3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for USP3
    Novus Biologicals USP3 Antibodies
    Search for Antibodies for USP3 at Abcam
    Cloud-Clone Corp. Antibodies for USP3
    ThermoFisher Antibodies for USP3
    LSBio Antibodies in human, mouse, rat for USP3

    USP3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for USP3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for USP3
    Cloud-Clone Corp. CLIAs for USP3
    Search eBioscience for ELISAs for USP3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    USP: Ubiquitin-specific peptidases

    5 InterPro protein domains:
     IPR001394 Peptidase_C19_UCH
     IPR018200 Pept_C19ubi-hydrolase_C_CS
     IPR013083 Znf_RING/FYVE/PHD
     IPR028889 UCH/PAN2
     IPR001607 Znf_UBP

    Graphical View of Domain Structure for InterPro Entry Q9Y6I4

    ProtoNet protein and cluster: Q9Y6I4

    2 Blocks protein domains:
    IPB001394 Ubiquitin thiolesterase
    IPB001607 Zn-finger in ubiquitin thiolesterase


    UniProtKB/Swiss-Prot: UBP3_HUMAN, Q9Y6I4
    Domain: Both protease activity and an intact zinc finger are required for H2A monodeubiquitination
    Similarity: Belongs to the peptidase C19 family. USP3 subfamily
    Similarity: Contains 1 UBP-type zinc finger
    Similarity: Contains 1 USP domain


    Find genes that share domains with USP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBP3_HUMAN, Q9Y6I4
    Function: Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required
    for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR)
    checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Genatlas biochemistry entry for USP3:
    ubiquitin specific protease 3,with two transcripts,both widely expressed at a low level and highly expressed in
    pancreas,cleaving a ubiquitin-proline bond,deubiquitin enzyme family

         Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004221ubiquitin thiolesterase activity IMP17980597
    GO:0004843ubiquitin-specific protease activity TAS10480896
    GO:0008234cysteine-type peptidase activity ----
    GO:0008270zinc ion binding IEA--
    GO:0016787hydrolase activity ----
         
    Find genes that share ontologies with USP3           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Usp3):
     cardiovascular system  homeostasis/metabolism 

    Find genes that share phenotypes with USP3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for USP3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for USP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for USP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for USP3

    miRNA
    Products:
        
    miRTarBase miRNAs that target USP3:
    hsa-mir-98-5p (MIRT027446), hsa-mir-10b-5p (MIRT047466), hsa-mir-18a-3p (MIRT040763), hsa-mir-26b-5p (MIRT028943)

    Block miRNA regulation of human, mouse, rat USP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP3 (see all 26):
    hsa-miR-146a hsa-miR-15a hsa-miR-106a hsa-miR-519a hsa-miR-1297 hsa-miR-424 hsa-miR-93 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidUSP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for USP3
    Predesigned siRNA for gene silencing in human, mouse, rat USP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for USP3

    Clone
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    OriGene clones in human, mouse for USP3 (see all 6)
    OriGene ORF clones in mouse, rat for USP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP3 (NM_004090)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP3
    Addgene plasmids for USP3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for USP3
    Browse ESI BIO Cell Lines and PureStem Progenitors for USP3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBP3_HUMAN, Q9Y6I4: Nucleus. Note=Localizes preferentially with monoubiquitinated H2A to chromatin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA17980597

    Find genes that share ontologies with USP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for USP3 About    
    See pathways by source

    SuperPathContained pathways About
    1Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for USP3
        Ubiquitin-Proteasome Dependent Proteolysis


        Pathway & Disease-focused RT2 Profiler PCR Array including USP3: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for USP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for USP3 (Q9Y6I43 ENSP000003696814) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOR1AIP2Q9H4963, ENSP000003565844I2D: score=1 I2D: score=1 STRING: ENSP00000356584
    EIF3BP558843, ENSP000003541254I2D: score=2 STRING: ENSP00000354125
    EIF3CQ996133, ENSP000003326044I2D: score=2 STRING: ENSP00000332604
    EIF3HO153723, ENSP000002766824I2D: score=2 STRING: ENSP00000276682
    EIF3IQ133473, ENSP000003626884I2D: score=2 STRING: ENSP00000362688
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle IMP17980597
    GO:0006281DNA repair IMP17980597
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016578histone deubiquitination IDA17980597
    GO:0031647regulation of protein stability IDA17980597

    Find genes that share ontologies with USP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for USP3 (UBP3)

    1 HMDB Compound for USP3    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for USP3 gene (2 alternative transcripts): 
    NM_001256702.1  NM_006537.3  

    Unigene Cluster for USP3:

    Ubiquitin specific peptidase 3
    Hs.458499  [show with all ESTs]
    Unigene Representative Sequence: NR_046341
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000561442 ENST00000560070 ENST00000380324(uc010uii.1 uc002amf.3 uc002amg.3 uc010uij.2 uc010uik.2 uc010bgs.3)
    ENST00000557884 ENST00000558157 ENST00000561326 ENST00000559873 ENST00000559192
    ENST00000559771 ENST00000559276 ENST00000558285 ENST00000559257 ENST00000538686(uc002ami.3)
    ENST00000559711 ENST00000558925 ENST00000558218 ENST00000561381 ENST00000559718

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat USP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate USP3 (see all 26):
    hsa-miR-146a hsa-miR-15a hsa-miR-106a hsa-miR-519a hsa-miR-1297 hsa-miR-424 hsa-miR-93 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidUSP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for USP3
    Predesigned siRNA for gene silencing in human, mouse, rat USP3
    Clone
    Products:
         
    OriGene clones in human, mouse for USP3 (see all 6)
    OriGene ORF clones in mouse, rat for USP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: USP3 (NM_004090)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for USP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP3
    Addgene plasmids for USP3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for USP3
    OriGene qSTAR qPCR primer pairs in human, mouse for USP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP3
      QuantiTect SYBR Green Assays in human, mouse, rat USP3
      QuantiFast Probe-based Assays in human, mouse, rat USP3

    Additional mRNA sequence: 

    AF073344.1 AF077040.1 AK022931.1 AK094444.1 AK300948.1 AK301236.1 AK301563.1 AK307810.1 
    AK309382.1 AK314223.1 AY461579.1 BC018113.2 BC065300.1 BC100029.1 BC107137.1 BC107138.1 
    BT007269.1 BX647760.1 NR_046341.1 NR_046342.1 

    24 DOTS entries:

    DT.427727  DT.213931  DT.86853868  DT.91914274  DT.100798066  DT.91993798  DT.92027113  DT.100008322 
    DT.121069165  DT.92409463  DT.95082713  DT.97829482  DT.100689433  DT.121069083  DT.121069107  DT.121069145 
    DT.40132237  DT.86857742  DT.95082709  DT.97841560  DT.40117767  DT.40305161  DT.75162765  DT.97841559 

    Selected AceView cDNA sequences (see all 230):

    AA371059 CD369463 CD172323 BQ109158 BM666136 AI291397 BQ212377 AI368920 
    AI001184 CF264923 BE550924 BX096101 BX421748 BM479585 AA830044 BM788363 
    AU142702 BC018113 C05514 Z39017 AI334394 BU165505 BM711047 AA629859 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for USP3 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a ·
    SP1:                                      -           -           -     -                                                           -                 -     -   
    SP2:                                      -     -     -           -                                                                 -                 -     -   
    SP3:                                      -     -     -           -     -                                                           -                 -     -   
    SP4:                                      -           -           -                                                                                             
    SP5:                                      -     -     -           -     -     -                                                                                 

    ExUns: 17b ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c · 20d
    SP1:        -                                       
    SP2:        -                                       
    SP3:        -                                       
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for USP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    USP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGCACAAT
    USP3 Expression
    About this image


    USP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
    USP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    USP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458499

    UniProtKB/Swiss-Prot: UBP3_HUMAN, Q9Y6I4
    Tissue specificity: Expressed in all tissues examined, with strongest expression in pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including USP3: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for USP3
    OriGene qSTAR qPCR primer pairs in human, mouse for USP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat USP3
    QuantiTect SYBR Green Assays in human, mouse, rat USP3
    QuantiFast Probe-based Assays in human, mouse, rat USP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for USP3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Usp31 , 5 ubiquitin specific peptidase 31, 5 90.77(n)1
    96.54(a)1
      9 (35.96 cM)5
    2354411  NM_144937.31  NP_659186.11 
     665146375 
    chicken
    (Gallus gallus)
    Aves USP31 ubiquitin specific peptidase 3 86.79(n)
    95.77(a)
      415369  XM_413755.4  XP_413755.3 
    lizard
    (Anolis carolinensis)
    Reptilia USP36
    ubiquitin specific peptidase 3
    89(a)
    1 ↔ 1
    GL343573.1(4335-17958)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.154902 Xenopus laevis transcribed sequence with moderate similarity more 79.42(n)    BU906546.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufe50h062 Danio rerio cDNA clone IMAGE5915429, partial cds 77.05(n)    BC059202.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0088051 AgaP_AGAP008805 54.91(n)
    53.68(a)
      1275662  XM_314931.4  XP_314931.4 
    worm
    (Caenorhabditis elegans)
    Secernentea usp-31 usp-3 49.8(n)
    41.65(a)
      190579  NM_061033.3  NP_493434.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBP56
    DOA46
    Putative ubiquitin-specific protease, closest para...
    Ubiquitin isopeptidase, required for recycling ubi...
    14(a)
    12(a)
    many ↔ many
    many ↔ many
    V(457806-460223) YER144C
    IV(584939-587719) YDR069C


    ENSEMBL Gene Tree for USP3 (if available)
    TreeFam Gene Tree for USP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for USP3 gene
    USP442  USP212  USP82  USP492  USP22  USP502  
    Selected SIMAP similar genes for USP3 using alignment to 16 protein entries:     UBP3_HUMAN (see all proteins) (see all similar genes):
    USP15    BRAP    USP48    USP4    USP33    HDAC6
    USP36    USP17L12    USP17L13    USP17L15    USP17L17    USP17L20
    USP17L21    USP17L22    USP17L18    USP17L19    USP42    USP8

    Find genes that share paralogs with USP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for USP3 (see all 1592)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs776914941,2
    C,F--63794729(+) TGGGAA/GAGGGT 4 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1887471821,2
    --63794856(+) GTCATA/GCTCCA 4 -- us2k10--------
    rs740229841,2
    C,F--63794924(+) GGTTGG/ATGGAG 4 -- us2k12Minor allele frequency- A:0.04WA 120
    rs2898161,2
    C,F,A,H--63794961(-) ATCTCT/CCCATG 4 -- us2k120Minor allele frequency- C:0.35NS EA NA WA 2524
    rs1461330151,2
    --63794988(+) GCCAAC/GGGCAG 4 -- us2k10--------
    rs1388738411,2
    --63795005(+) TTGTTC/TCTCCT 4 -- us2k10--------
    rs1932792571,2
    --63795122(+) CACATA/GTTCCT 4 -- us2k10--------
    rs1428075741,2
    C--63795281(+) ACAACG/TCATCA 4 -- us2k10--------
    rs1851019821,2
    --63795384(+) AAAGGA/GTGAGC 4 -- us2k10--------
    rs740229851,2
    C,F--63795459(+) CGTGGG/CAGGTA 4 -- us2k12Minor allele frequency- C:0.04WA 120

    HapMap Linkage Disequilibrium report for USP3 (63796793 - 63886839 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for USP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833034CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing USP3
    DNA2.0 Custom Variant and Variant Library Synthesis for USP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604728    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for USP3:
    Gilles de la Tourette syndrome

    Find genes that share disorders with USP3           About GenesLikeMe

    Genetic Association Database (GAD): USP3
    Human Genome Epidemiology (HuGE) Navigator: USP3 (2 documents)

    Export disorders for USP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for USP3 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with USP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and chromosomal localization of USP3, a novel human ubiquitin-specific protease. (PubMed id 10480896)1, 2, 9 Sloper-Mould K.E.... Baker R.T. (J. Biol. Chem. 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. (PubMed id 20445134)1, 4 Smith N.L....Vasan R.S. (Circ Cardiovasc Genet 2010)
    4. Human USP3 is a chromatin modifier required for S phase progression and genome stability. (PubMed id 17980597)1, 2 Nicassio F.... Citterio E. (Curr. Biol. 2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    7. A strategy for modulation of enzymes in the ubiquitin system. (PubMed id 23287719)1 Ernst A.... Sidhu S.S. (Science 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts. (PubMed id 22743239)1 Dato S....Christiansen L. (Mech. Ageing Dev. 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9960 HGNC: 12626 AceView: USP3 Ensembl:ENSG00000140455 euGenes: HUgn9960
    ECgene: USP3 H-InvDB: USP3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for USP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for USP3 gene:
    Search GeneIP for patents involving USP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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