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Aliases for USP29 Gene

Aliases for USP29 Gene

  • Ubiquitin Specific Peptidase 29 2 3 5
  • Ubiquitin-Specific-Processing Protease 29 3 4
  • Deubiquitinating Enzyme 29 3 4
  • Ubiquitin Thioesterase 29 3 4
  • Ubiquitin-Specific Processing Protease 3
  • Ubiquitin Specific Protease 29 2
  • Ubiquitin Thiolesterase 29 3
  • HOM-TES-84/86 3
  • EC 4
  • EC 63

External Ids for USP29 Gene

Previous GeneCards Identifiers for USP29 Gene

  • GC19P058538
  • GC19P058094
  • GC19P062316
  • GC19P062331
  • GC19P057631
  • GC19P053944

Summaries for USP29 Gene

GeneCards Summary for USP29 Gene

USP29 (Ubiquitin Specific Peptidase 29) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is USP26.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for USP29 Gene

Genomics for USP29 Gene

Regulatory Elements for USP29 Gene

Enhancers for USP29 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around USP29 on UCSC Golden Path with GeneCards custom track

Genomic Location for USP29 Gene

57,119,138 bp from pter
57,131,926 bp from pter
12,789 bases
Plus strand

Genomic View for USP29 Gene

Genes around USP29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
USP29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for USP29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for USP29 Gene

Proteins for USP29 Gene

  • Protein details for USP29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 29
    Protein Accession:

    Protein attributes for USP29 Gene

    922 amino acids
    Molecular mass:
    104156 Da
    Quaternary structure:
    No Data Available

neXtProt entry for USP29 Gene

Proteomics data for USP29 Gene at MOPED

Selected DME Specific Peptides for USP29 Gene

Post-translational modifications for USP29 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for USP29 Gene

Domains & Families for USP29 Gene

Gene Families for USP29 Gene

Protein Domains for USP29 Gene

Suggested Antigen Peptide Sequences for USP29 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
  • Contains 1 USP domain.
  • Belongs to the peptidase C19 family.
genes like me logo Genes that share domains with USP29: view

Function for USP29 Gene

Molecular function for USP29 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme Numbers (IUBMB) for USP29 Gene

Gene Ontology (GO) - Molecular Function for USP29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with USP29: view

Phenotypes for USP29 Gene

genes like me logo Genes that share phenotypes with USP29: view

Animal Model Products

miRNA for USP29 Gene

miRTarBase miRNAs that target USP29

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for USP29 Gene

Localization for USP29 Gene

Subcellular locations from

Jensen Localization Image for USP29 Gene COMPARTMENTS Subcellular localization image for USP29 gene
Compartment Confidence
cytosol 2
extracellular 2
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for USP29 Gene

Pathways & Interactions for USP29 Gene

genes like me logo Genes that share pathways with USP29: view

Pathways by source for USP29 Gene

1 Qiagen pathway for USP29 Gene

Gene Ontology (GO) - Biological Process for USP29 Gene


No data available for SIGNOR curated interactions for USP29 Gene

Drugs & Compounds for USP29 Gene

(1) Additional Compounds for USP29 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with USP29: view

Transcripts for USP29 Gene

mRNA/cDNA for USP29 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for USP29 Gene

Ubiquitin specific peptidase 29:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for USP29 Gene

No ASD Table

Relevant External Links for USP29 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for USP29 Gene

mRNA expression in normal human tissues for USP29 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for USP29 Gene

This gene is overexpressed in Testis (x49.0).

Protein differential expression in normal tissues from HIPED for USP29 Gene

This gene is overexpressed in Cerebrospinal fluid (32.0), Heart (16.3), Cervix (11.0), and Esophagus (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for USP29 Gene

SOURCE GeneReport for Unigene cluster for USP29 Gene Hs.515632

genes like me logo Genes that share expression patterns with USP29: view

Protein tissue co-expression partners for USP29 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for USP29 Gene

Orthologs for USP29 Gene

This gene was present in the common ancestor of chordates.

Orthologs for USP29 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Usp29 35
  • 64.65 (n)
  • 48.24 (a)
Usp29 16
Usp29 36
  • 43 (a)
(Pan troglodytes)
Mammalia USP29 35
  • 98.92 (n)
  • 97.94 (a)
(Rattus norvegicus)
Mammalia Usp29 35
  • 63.77 (n)
  • 47.1 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 18 (a)
(Danio rerio)
Actinopterygii USP29 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2829 36
  • 25 (a)
Species with no ortholog for USP29:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for USP29 Gene

Gene Tree for USP29 (if available)
Gene Tree for USP29 (if available)

Paralogs for USP29 Gene

Paralogs for USP29 Gene

(2) SIMAP similar genes for USP29 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with USP29: view

Variants for USP29 Gene

Sequence variations from dbSNP and Humsavar for USP29 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3795003 - 57,130,431(-) GGATT(C/T)TGAGG reference, missense
rs1027392 - 57,129,778(+) TGGCA(A/G)CATGC reference, missense
rs12975737 -- 57,120,620(+) tgtct(C/T)tacta intron-variant
rs12979911 -- 57,119,916(+) AGAGC(A/C)CGTAC upstream-variant-2KB
rs12980671 -- 57,120,288(+) AGATC(A/G)TGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for USP29 Gene

Variant ID Type Subtype PubMed ID
nsv912523 CNV Gain 21882294

Variation tolerance for USP29 Gene

Residual Variation Intolerance Score: 62.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.46; 64.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for USP29 Gene

Disorders for USP29 Gene

Relevant External Links for USP29

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for USP29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for USP29 Gene

Publications for USP29 Gene

  1. Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4. (PMID: 10958632) Kim J. … Stubbs L. (Genome Res. 2000) 3 4 23 67
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  3. USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination. (PMID: 24632611) MartA-n Y. … Freire R. (Oncogene 2015) 3
  4. JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress. (PMID: 21285945) Liu J. … Levens D. (EMBO J. 2011) 3
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for USP29 Gene

Sources for USP29 Gene