USP29 Gene
protein-coding GIFtS: 51
GCID: GC19P057631
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ubiquitin specific peptidase 29(Previous name: ubiquitin specific protease 29 )
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Aliases
for USP29 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Specific Peptidase 291 2 | | Ubiquitin Carboxyl-Terminal Hydrolase 292 | | Deubiquitinating Enzyme 292 3 | | Ubiquitin Thiolesterase 292 | | Ubiquitin Thioesterase 292 3 | | Ubiquitin-Specific Processing Protease2 | | Ubiquitin-Specific-Processing Protease 292 3 | | EC 3.4.19.123 | | Ubiquitin Specific Protease 291 | | EC 3.1.2.158 | | HOM-TES-84/862 | | |
Export aliases for USP29 gene to outside databasesPrevious GC identifers: GC19P058538 GC19P058094 GC19P062316 GC19P062331 GC19P053944 |
Summaries
for USP29 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for USP29 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP29 gene promoter:
SRF p53 SRF (504 AA) HNF-1 FOXD3 HNF-1A
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP29
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP29 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.4USP29 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P057631: view genomic region
(about GC identifiers)
Start:
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57,631,411 bp from pter |
End:
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57,643,294 bp from pter |
Size:
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11,884 bases |
Orientation:
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plus strand |
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Proteins
for USP29 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBP29_HUMAN, Q9HBJ7 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 29 Size: 922 amino acids; 104156 DaExplore the universe of human proteins at neXtProt for USP29: NX_Q9HBJ7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HBJ7
3 DME Specific Peptides for USP29 (Q9HBJ7)
USP29 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065954.1
ENSEMBL proteins: ENSP00000254181
Human Recombinant Protein Products for USP29:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005575 | cellular_component |
ND | -- |
USP29 for ontologies About GeneDecksing
USP29 Antibody Products:
Assay Products for USP29: |
Protein
Domains /
Families
for USP29 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP29 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HBJ7ProtoNet protein and cluster: Q9HBJ7 1 Blocks protein family: IPB001394 Ubiquitin thiolesterase
UniProtKB/Swiss-Prot: UBP29_HUMAN, Q9HBJ7Similarity: Belongs to the peptidase C19 family |
Function
for USP29 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: UBP29_HUMAN, Q9HBJ7Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) Enzyme Numbers (IUBMB): EC 3.1.2.152 EC 3.4.19.121
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004221 | ubiquitin thiolesterase activity |
TAS | 10958632 | | GO:0008234 | cysteine-type peptidase activity |
IEA | -- |
USP29 for ontologies About GeneDecksing
Phenotypes:
1 MGI mutant phenotype (inferred from 3 alleles ) (MGI details for Usp29):
USP29 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP29 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP29
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: USP29 (NM_020903) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP29 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP29 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP29 |
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Pathways & Interactions
for USP29 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitin-Proteasome Dependent Proteolysis | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for USP29
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP29
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for USP29 (Q9HBJ72, 3 ENSP000002541814) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006464 | cellular protein modification process |
NAS | -- | | GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- |
USP29 for ontologies About GeneDecksing
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Drugs & Compounds
for USP29 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for USP29
1 HMDB Compound for USP29 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Water | Dihydrogen oxide (see all 2) | 7732-18-5 | -- |
Search CenterWatch for drugs/clinical trials and news about USP29 / UBP29
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Transcripts
for USP29 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for USP29 gene: NM_020903.2 Unigene Cluster for USP29: Ubiquitin specific peptidase 29 Hs.515632 [show with all ESTs]Unigene Representative Sequence: NM_0209031 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000254181(uc002qny.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP29 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP29
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: USP29 (NM_020903) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for USP29 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP29 |
Additional cDNA sequence: AF124433.1 AF229438.1 AK308285.1 BC130394.1 BC130398.1 1 DOTS entry: DT.40129292 6 AceView cDNA sequences: AF229438 NM_020903 BX112459 AA909508 AF124433 BU569620
GeneLoc Exon Structure
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Expression
for USP29 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| USP29 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGTTTGAA
About this image
See USP29 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for USP29
SOURCE GeneReport for Unigene cluster: Hs.515632
SABiosciences Custom PCR Arrays for USP29
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP29
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat USP29 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP29 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP29 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP29 |
Orthologs
for USP29 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for USP29 gene from 4/16 species (see all 16) About this table
ENSEMBL Gene Tree for USP29 (if available)
TreeFam Gene Tree for USP29 (if available) |
Paralogs
for USP29 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for USP29 gene
- USP372 USP262
2 SIMAP similar genes for USP29 using alignment to 4 protein entries: UBP29_HUMAN (see all proteins):USP26 USP37
USP29 for paralogs About GeneDecksing
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Genomic Variants
for USP29 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for USP29 (57631411 - 57643294 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for USP29: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP29 |
|
Disorders
/ Diseases
for USP29 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP29 for disorders About GeneDecksing
OMIM gene information: 609546
OMIM disorders: --
3  diseases for USP29: About MalaCardsangelman syndrome ovarian cancer colorectal cancer
1 disease from the University of Copenhagen DISEASES database for USP29:Angelman syndrome Human Genome Epidemiology (HuGE) Navigator: USP29 (1 document)
Export disorders for USP29 gene to outside databases
|
Publications
for USP29 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for USP29 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with USP29) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4. (PubMed id 10958632)1, 2, 9 Kim J.... Stubbs L. (2000)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- JTV1 co-activates FBP to induce USP29 transcription a nd stabilize p53 in response to oxidative stress. (PubMed id 21285945)1 Liu J....Levens D. (2011)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Two evolutionarily conserved sequence elements for Peg3/Usp29 transcription. (PubMed id 19068137)9 Kim J.D....Kim J. (2008)
- Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. (PubMed id 11739384)9 Li Z.... Wu G. (2002)
- Imprinting and evolution of two Kruppel-type zinc-finger genes, ZIM3 and ZNF264, located in the PEG3/USP29 imprinted domain. (PubMed id 11543637)9 Kim J.... Stubbs L. (2001)
- Zinc-finger UBPs: regulators of deubiquitylation. (PubMed id 18603431)9 Bonnet J....Devys D. (2008)
- Gender specific differences in levels of DNA methylation at selected loci from human total blood: a tendency toward higher methylation levels in males. (PubMed id 17851693)9 El-Maarri O....Oldenburg J. (2007)
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External Searches for USP29 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing USP29 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USP29 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing USP29 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for USP29 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for USP29 gene:
Search GeneIP for patents involving USP29
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for USP29 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for USP29 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for USP29 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for USP29 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for USP29 | | OriGene 3'-UTR Clone for USP29 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for USP29 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for USP29 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat USP29 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing USP29 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat USP29 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat USP29 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat USP29 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat USP29 |
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| | | | Search Tocris compounds for USP29 |
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 | | | USP29 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for USP29 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for USP29 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat USP29 |
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